ORCID Profile
0000-0002-6051-2580
Current Organisations
King Edward Memorial Hospital
,
University of Western Australia
,
Perth Children's Hospital
,
Newborn Emergency Transport Service Western Australia
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Publisher: BMJ
Date: 27-06-2014
DOI: 10.1136/ARCHDISCHILD-2013-305763
Abstract: Therapeutic hypothermia (HT) delays the cytokine response in infants with neonatal encephalopathy (NE). To determine if HT delayed the C-reactive protein (CRP) response and altered white blood cell (WBC), neutrophil and platelet count course during the first week of life in infants with NE. Retrospective cohort study. Regional neonatal intensive care unit, UK. 104 term infants with NE (38 normothermia (NT) and 66 HT) born between 1998 and 2010. Infants not exposed to prenatal sepsis risk factors were classified as group 'A' and exposed infants to group 'B'. CRP >10 mg/L was defined as significant response. Time to CRP >10 mg/L, peak CRP, WBC, neutrophil and platelet count. Blood cultures were negative in all the infants. In babies who had CRP response, HT delayed time to CRP >10 mg/L (median (95% CI): group A, HT: 36 h (28.3 to 48.0) NT: 24 h (0.0 to 24.0) p=0.001 group B, HT: 30 h (15.2 to 56.8) NT: 12 h (0.0 to 24.0) p=0.009) and time to peak CRP (median (95% CI): group A, HT: 60 h (60.0 to 72.0) NT: 36 h (0.0 to 48.0) p=0.001 group B, HT: 84 h (62.1 to 120.0) NT: 24 h (0.0 to 36.0) p=0.001). Compared with NT, HT was associated with reduction in slope of CRP elevation by 0.5 (95% CI 0.04 to 0.97), WBC by 2.18×10(9)/L (95% CI 0.002 to 4.35) and platelet count by 32.3×10(9)/L (95% CI 2.75 to 61.8) independent of exposure to sepsis risk, meconium aspiration and severity of asphyxia. Therapeutic hypothermia delayed the initiation of CRP and its peak response, and depressed the WBC and platelet count compared with NT.
Publisher: Cold Spring Harbor Laboratory
Date: 25-09-2020
DOI: 10.1101/2020.09.23.20200485
Abstract: Bubble CPAP may be used in infants with suspected or confirmed COVID-19. Electrostatic filters may reduce cross-infection. This study aims to determine if including a filter in the bubble CPAP circuit impacts stability of pressure delivery. A new electrostatic filter was placed before (pre) or after (post) the bubble CPAP generator, or with no filter (control) in an in vitro study. Pressure was recorded at the nasal interface for 18 h (6 L/min 7 cmH 2 O) on three occasions for each configuration. Filter failure was defined as pressure cmH 2 0 for 60 continuous minutes. The filter was weighed before and after each experiment. Mean (SD) time to reach the fail-point was 257 (116) min and 525 (566) min for filter placement pre- and post-CPAP generator, respectively. Mean pressure was higher throughout in the pre-generator position compared to control. The filter weight was heavier at study end in the pre-compared to the post-generator position. Placement of the filter at the pre-generator position in a bubble CPAP circuit should be avoided due to unstable mean pressure. Filters are likely to become saturated with water over time. The post-generator position may accommodate a filter, but regular pressure monitoring and early replacement are required.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 02-2014
Publisher: BMJ
Date: 10-2014
Publisher: BMJ
Date: 10-2014
Publisher: BMJ
Date: 10-2014
Publisher: Elsevier BV
Date: 10-2014
DOI: 10.1016/J.RESUSCITATION.2014.07.002
Abstract: Heart rate (HR) plays an important role in the assessment of stress during therapeutic hypothermia (TH) for neonatal encephalopathy we aimed to quantify the effect on HR of endotracheal (ET) intubation and drugs given to facilitate it. If atropine premedication independently increased HR, the main indicator of effective sedation, we hypothesised that increased sedation would have been given. Thirty-two, term, neonates recruited into a randomised pilot study comparing TH and TH combined with 50% Xenon inhalation were studied. Indications for ET intubation included: resuscitation at delivery, clinical need and elective re-intubation with a cuffed ET tube if randomised to Xenon. Standard intubation drugs comprised one or more of intravenous morphine, atropine, and suxamethonium. Local cooling guidelines were followed including morphine infusion for sedation. At postnatal hours five to eight atropine increased HR in a linear regression model (p<0.01). All other independent variables were excluded. Where more than one dose of atropine was given total morphine sedation given up to 8h into the treatment period was significantly higher (p<0.01). We have shown that atropine premedication for ET intubation significantly increased HR, the main indicator of effective sedation and total morphine dose for sedation during early TH was increased where more than one dose of atropine was given. Bradycardia was not reported in any neonate, even without atropine premedication. We suggest that the use of atropine as part of standard premedication for ET intubation of term neonates undergoing TH should be reconsidered.
Publisher: BMJ
Date: 10-2014
Publisher: Bentham Science Publishers Ltd.
Date: 02-2008
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 10-2013
Publisher: Cold Spring Harbor Laboratory
Date: 13-01-2021
DOI: 10.1101/2021.01.12.21249639
Abstract: Incomplete vaccination in Australia is greatly due to vaccine hesitancy, which is driven by multiple factors. Studies analysing the effect of behavioural ‘nudges’ on vaccine uptake have shown promising results. Although there is some evidence for positively framed SMS vaccine messages, evidence is lacking for loss-based framed messages which may be highly effective but may paradoxically risk increasing vaccine hesitancy. This pilot study aimed to evaluate the effect of loss-based framed SMS messages on vaccine hesitancy. This single-blinded randomised controlled trial enrolled pregnant women from antenatal clinics in King Edward Memorial Hospital, Perth, WA which delivers approximately 6000 higher-risk infants per year. Participants were randomised to receive either a loss-based framed SMS message warning of the risks of failure to vaccinate, or a sham SMS message unrelated to vaccination, and were asked to complete the short-scale vaccine hesitancy questionnaire before and after the intervention. The application of behavioural sciences through SMS-reminders has the potential to improve vaccination rates. There are difficulties in engaging with parents of newborns about vaccine hesitancy. Further research is warranted using other approaches to recruitment. Pilot randomised controlled trial on the use of SMS reminders to influence vaccine hesitancy Application of behavioural economics, nudge techniques and mobile health Vaccine hesitancy measured using the short-scale PACV questionnaire There are difficulties in engaging with parents of newborns about vaccine hesitancy Further research needed to optimise message framing, timing and reduce vaccine hesitancy The trial is registered with the Australia and New Zealand Clinical Trials Register (ACTRN12618001510235).
Location: United Kingdom of Great Britain and Northern Ireland
Location: Australia
No related grants have been discovered for Jonathan Davis.