ORCID Profile
0000-0002-9658-253X
Current Organisation
Sankt Marienhospital Vechta gGmbH
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Publisher: Massachusetts Medical Society
Date: 13-01-2005
DOI: 10.1056/NEJMOA040975
Publisher: Springer Science and Business Media LLC
Date: 16-01-2013
Publisher: Springer Science and Business Media LLC
Date: 2021
DOI: 10.1007/S11916-020-00920-5
Abstract: We review the relevance of quantitative sensory testing (QST) in light of acute and chronic postoperative pain and associated challenges. Predicting the occurrence of acute and chronic postoperative pain with QST can help identify patients at risk and allows proactive preventive management. Generally, central QST testing, such as temporal summation of pain (TSP) and conditioned pain modulation (CPM), appear to be the most promising modalities for reliable prediction of postoperative pain by QST. Overall, QST testing has the best predictive value in patients undergoing orthopedic procedures. Current evidence underlines the potential of preoperative QST to predict postoperative pain in patients undergoing elective surgery. Implementing QST in routine preoperative screening can help advancing traditional pain therapy toward personalized perioperative pain medicine.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 04-2008
DOI: 10.1097/ALN.0B013E31816721FA
Abstract: Laboratory studies suggest that nitrous oxide augments brain injury after ischemia or hypoxia. The authors examined the relation between nitrous oxide use and outcomes using data from the Intraoperative Hypothermia for Aneurysm Surgery Trial. The Intraoperative Hypothermia for Aneurysm Surgery Trial was a prospective randomized study of the impact of intraoperative hypothermia (temperature = 33 degrees C) versus normothermia (temperature = 36.5 degrees C) in patients with aneurysmal subarachnoid hemorrhage undergoing surgical clipping. Anesthesia was dictated by a limited-options protocol with the use of nitrous oxide determined by in idual anesthesiologists. All patients were assessed daily for 14 days after surgery or until hospital discharge. Neurologic and neuropsychological testing were conducted at 3 months after surgery. Outcome data were analyzed via both univariate tests and multivariate logistic regression analysis correcting for factors thought to influence outcome. An odds ratio (OR) greater than 1.0 denotes a worse outcome in patients receiving nitrous oxide. Outcome data were available for 1,000 patients, of which 373 received nitrous oxide. There was no difference between groups in the development of delayed ischemic neurologic deficit. At 3 months after surgery, there were no significant differences between groups in any outcome variable: Glasgow Outcome Score (OR, 0.84 95% confidence interval [CI], 0.63-1.14 P = 0.268), National Institutes of Health Stroke Scale (OR, 1.29 95% CI, 0.96-1.73 P = 0.087), Rankin Disability Score (OR, 0.84 95% CI, 0.61-1.15 P = 0.284), Barthel Activities of Daily Living Index (OR, 1.01 95% CI, 0.68-1.51 P = 0.961), or neuropsychological testing (OR, 1.26 95% CI, 0.85-1.87 P = 0.252). In a population of patients at risk for ischemic brain injury, nitrous oxide use had no overall beneficial or detrimental impact on neurologic or neuropsychological outcomes.
Location: No location found
No related grants have been discovered for Christian Hönemann.