ORCID Profile
0000-0001-9646-0121
Current Organisations
Queensland University of Technology
,
University of Melbourne
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Publisher: Wiley
Date: 20-09-2016
DOI: 10.1002/CBIN.10672
Abstract: The first description of intrachromosomal fibers was made by Baranetzky in 1880. Since that time, a plethora of fibrillar substructures have been described inside the mitotic chromosomes, and published data indicate that chromosomes may be formed as a result of the hierarchical folding of chromatin fibers. In this review, we examine the evolution and the current state of research on the morphological organization of mitotic chromosomes.
Publisher: Springer Science and Business Media LLC
Date: 13-03-2019
DOI: 10.1038/S41598-019-40823-Z
Abstract: It is widely accepted that memory consolidation requires de-novo transcription of memory-related genes. Epigenetic modifications, particularly histone acetylation, may facilitate gene transcription, but their potential molecular targets are poorly characterized. In the current study, we addressed the question of epigenetic control of atypical protein kinases (aPKC) that are critically involved in memory consolidation and maintenance. We examined the patterns of expression of two aPKC genes ( Prkci and Prkcz ) in rat cultured cortical neurons treated with histone deacetylase inhibitors. Histone hyperacetylation in the promoter region of Prkci gene elicited direct activation of transcriptional machinery, resulting in increased production of PKCλ mRNA. In parallel, histone hyperacetylation in the upstream promoter of Prkcz gene led to appearance of the corresponding PKCζ transcripts that are almost absent in the brain in resting conditions. In contrast, histone hyperacetylation in the downstream promoter of Prkcz gene was accompanied by a decreased expression of the brain-specific PKMζ products. We showed that epigenetically-triggered differential expression of PKMζ and PKCζ mRNA depended on protein synthesis. Summarizing, our results suggest that genes, encoding memory-related aPKC, may represent the molecular targets for epigenetic regulation through posttranslational histone modifications.
Publisher: Springer Science and Business Media LLC
Date: 12-09-2017
Publisher: Cold Spring Harbor Laboratory
Date: 15-08-2023
DOI: 10.1101/2023.08.15.552960
Abstract: Among land plants, genome sizes vary remarkably by 2,200-fold. This variation depends on the loss and gain of non-coding DNA sequences, forming different heterochromatin complexes during interphase. In plants with a giant genome, the major part of chromatin stays condensed in interphase, forming a dense meshwork of heterochromatin threads, called interphase chromonemata. Using super-resolution light and electron microscopy, we studied the ultrastructure of chromonemata during and after replication in root meristem nuclei of Nigella damascena L. During S-phase, heterochromatin undergoes transient decompaction locally at the active sites of DNA synthesis, and due to the heterochromatin abundance, chromonema replication is accompanied by a robust chromonema meshwork disassembly, which led to the general reorganization of the nucleus morphology visible even by conventional light microscopy. After replication, the heterochromatin condenses again, restoring the chromonema structure. Thus, we showed that heterochromatin replication in interphase nuclei of giant-genome plants induces a global chromonema decondensation and reorganization.
Publisher: Pleiades Publishing Ltd
Date: 07-2013
Publisher: Elsevier BV
Date: 08-2020
Publisher: Allerton Press
Date: 12-2010
Location: No location found
Location: Russian Federation
Location: Russian Federation
No related grants have been discovered for Maria Kuznetsova.