ORCID Profile
0000-0001-7714-9848
Current Organisation
The University of Auckland
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Publisher: Elsevier BV
Date: 11-2015
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2022
Publisher: ACM
Date: 15-11-2013
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2023
Publisher: IEEE
Date: 02-2015
Publisher: IEEE
Date: 05-2017
DOI: 10.1109/DISE.2017.9
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 02-2022
Publisher: IEEE
Date: 04-2017
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 05-2021
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 15-04-2021
Publisher: ACM
Date: 24-10-2016
Publisher: Elsevier BV
Date: 10-2013
DOI: 10.1016/J.BIOS.2013.04.033
Abstract: Lab-on-a-Chip (LOC) biomicrofluidic technologies are rapidly emerging bioanalytical tools that can miniaturize and revolutionize in situ research on embryos of small vertebrate model organisms such as zebrafish (Danio rerio) and clawed African frog (Xenopus laevis). Despite considerable progress being made in fabrication techniques of chip-based devices, they usually still require excessive and manual actuation and data acquisition that significantly reduce throughput and introduce operator-related analytical bias. This work describes the development of a proof-of-concept embedded platform that integrates an innovative LOC zebrafish embryo array technology with an electronic interface to provide higher levels of laboratory automation for in situ biotests. The integrated platform was designed to perform automatic immobilization, culture and treatment of developing zebrafish embryos during fish embryo toxicity (FET) biotests. The system was equipped with a stepper motor driven stage, solenoid-actuated pinch valves, miniaturized peristaltic pumps as well as Peltier heating module. Furthermore, a Field Programmable Gate Array (FPGA) was used to implement an embedded hardware/software solution and interface to enable real-time control over embryo loading and immobilization accurate microfluidic flow control temperature stabilization and also automatic time-resolved image acquisition of developing zebrafish embryos. This work presents evidence that integration of embedded electronic interfaces with microfluidic chip-based technologies can bring the Lab-on-a-Chip a step closer to fully automated analytical systems.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 07-2022
No related grants have been discovered for Zoran Salcic.