ORCID Profile
0000-0002-5326-3432
Current Organisations
Macquarie University Faculty of Science and Engineering
,
University of Nottingham
,
Macquarie University
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Springer Berlin Heidelberg
Date: 2009
Publisher: Wiley
Date: 16-09-2021
DOI: 10.1111/BPH.15538
Abstract: The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at oi/bph.15538. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is ided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
Publisher: Elsevier BV
Date: 11-2015
Publisher: Elsevier BV
Date: 04-2015
DOI: 10.1016/J.BRAINRES.2015.01.049
Abstract: Hypotensive drugs have been used to identify central neurons that mediate compensatory baroreceptor reflex responses. Such drugs also increase blood glucose. Our aim was to identify the neurochemical phenotypes of sympathetic preganglionic neurons (SPN) and adrenal chromaffin cells activated following hydralazine (HDZ 10mg/kg) administration in rats, and utilize this and SPN target organ destination to ascribe their function as cardiovascular or glucose regulating. Blood glucose was measured and adrenal chromaffin cell activation was assessed using c-Fos immunoreactivity (-ir) and phosphorylation of tyrosine hydroxylase, respectively. The activation and neurochemical phenotype of SPN innervating the adrenal glands and celiac ganglia were determined using the retrograde tracer cholera toxin B subunit, in combination with in situ hybridization and immunohistochemistry. Blood glucose was elevated at multiple time points following HDZ administration but little evidence of chromaffin cell activation was seen suggesting non-adrenal mechanisms contribute to the sustained hyperglycemia. 16±0.1% of T4-T11 SPN contained c-Fos and of these: 24.3±1.4% projected to adrenal glands and 29±5.5% projected to celiac ganglia with the rest innervating other targets. 62.8±1.4% of SPN innervating adrenal glands were activated and 29.9±3.3% expressed PPE mRNA whereas 53.2±8.6% of SPN innervating celiac ganglia were activated and 31.2±8.8% expressed PPE mRNA. CART-ir SPN innervating each target were also activated and did not co-express PPE mRNA. Neurochemical coding reveals that HDZ administration activates both PPE+SPN, whose activity increase glucose mobilization causing hyperglycemia, as well as CART+SPN whose activity drive vasomotor responses mediated by baroreceptor unloading to raise vascular tone and heart rate.
Publisher: IEEE
Date: 2007
DOI: 10.1109/TASE.2007.34
Publisher: SCITEPRESS - Science and Technology Publications
Date: 2018
Publisher: ACM
Date: 09-10-2011
Publisher: Universitat Politècnica València
Date: 21-06-2017
Abstract: This paper describes how to adapt a static code analyzer to provide feedback novice programmers and their teachers. Current analyzers have been built to give feedback to experienced programmers who work on software projects or systems. The type of feedback and the type of analysis of these tools focusses on mistakes that are relevant within that context, and help with debugging software system. When teaching novice programmers this type of advice is often not particularly useful. It would be instead more useful to use these techniques to identify problem in the understanding of students of important programming concepts. This paper first explores in what respect static analyzers support the learning and teaching of programming, and what can be implemented based on existing static analysis technology. It presents an extension of static analyzer PMD to create feedback that is more valuable to novice programmers. To answer the question if these techniques are able to find conceptual mistakes that are characteristic for novice programmers make, we ran it over a number of student projects, and compared these results with publicly available mature software projects.
Publisher: Springer Berlin Heidelberg
Date: 2004
Publisher: IEEE
Date: 08-2011
Publisher: Springer Berlin Heidelberg
Date: 2004
Publisher: Springer International Publishing
Date: 2015
Publisher: Springer International Publishing
Date: 2021
Publisher: IEEE
Date: 09-2008
DOI: 10.1109/SCAM.2008.15
Publisher: IEEE
Date: 11-2007
Publisher: Elsevier BV
Date: 11-2008
Publisher: Wiley
Date: 21-10-2017
DOI: 10.1111/BPH.13882
Publisher: Springer International Publishing
Date: 2019
Publisher: Elsevier BV
Date: 10-2004
Publisher: Wiley
Date: 12-2015
DOI: 10.1111/BPH.13347
Publisher: Springer Berlin Heidelberg
Date: 2010
Publisher: Springer Berlin Heidelberg
Date: 2008
Publisher: Open Publishing Association
Date: 15-03-2017
DOI: 10.4204/EPTCS.244.1
Publisher: IEEE
Date: 11-2014
Publisher: Open Publishing Association
Date: 15-03-2017
DOI: 10.4204/EPTCS.244.3
Publisher: Springer Science and Business Media LLC
Date: 08-10-2013
DOI: 10.1007/S00429-013-0642-3
Abstract: Hypoglycemia elicits physiological and behavioral responses which are mediated in part by neurons within the ventrolateral medulla (VLM). The present study describes the neurochemistry of neurons activated by glucoprivation (2-deoxy-D-glucose, 2DG), specifically those within regions containing the A1, caudal C1 (cC1) and rostral C1 (rC1) cell groups. 2DG induced c-Fos immunoreactivity throughout the VLM. Activated neurons expressing prepro-cocaine and hetamine-regulated transcript (PPCART), neuropeptide Y (NPY), glutamic acid decarboxylase (GAD67) or prepro-enkephalin (PPE) mRNA and/or immunoreactivity (-ir) for tyrosine hydroxylase (TH) were identified. TH(+) neurons were recruited in a dose-dependent manner. At high doses of 2DG [400 mg/kg, (n = 6)], 76 ± 1.2 % of activated neurons were TH(+) representing 52 ± 1.3 % of the total TH population. Virtually all activated neurons in the A1 and cC1 regions but only 60 % in the rC1 region were TH(+). Within the A1 region, TH(+), TH(+)NPY(+) and TH(+)NPY(+)PPE(+) subpopulations were activated and likely regulate vasopressin, oxytocin, and corticotrophin releasing hormone (CRH) from the hypothalamus. Within the cC1 region, non-TH neurons, TH(+)NPY(+), TH(+)NPY(+)PPCART(+), and TH(+)NPY(+)PPE(+) subpopulations were activated, likely regulating autonomic hypothalamic neurons or CRH and thyrotropin releasing hormone secretion. Within the rC1 region, non-TH neurons (40 % of those activated) were predominantly PPE(+) and were recruited by higher 2DG doses. Of the TH(+) activated neurons in the rC1 region, many expressed PPCART and half expressed NPY. The activated spinally projecting population was almost entirely TH(+)PPCART(+) and is likely to regulate adrenaline and glucagon release. These data indicate that glucoprivation activates at least nine phenotypically distinct populations of neurons in the VLM.
Publisher: Elsevier BV
Date: 12-2012
Publisher: Springer Science and Business Media LLC
Date: 06-05-2020
DOI: 10.1007/S00236-020-00378-3
Abstract: I have known Rob van Glabbeek as a colleague for 16 years, of which eight years were in the same research group. However, this only amounts to less than half of his professional life which started in the mid-1980s at the Centrum voor Wiskunde en Informatica in Amsterdam. In this article, I am trying to piece together the information I got from colleagues as well as from Rob himself—to the best of my recollection—to give an insight into Rob as a colleague, researcher, and person.
Publisher: Springer Berlin Heidelberg
Date: 2001
Publisher: Springer International Publishing
Date: 2018
Publisher: Springer International Publishing
Date: 2018
Publisher: American Chemical Society (ACS)
Date: 17-10-2014
DOI: 10.1021/PR500719F
Abstract: Repeat administration of psychostimulants, such as meth hetamine, produces a progressive increase in locomotor activity (behavioral sensitization) in rodents that is believed to represent the underlying neurochemical changes driving psychoses. Alterations to the prefrontal cortex (PFC) are suggested to mediate the etiology and maintenance of these behavioral changes. As such, the aim of the current study was to investigate changes to protein expression in the PFC in male rats sensitized to meth hetamine using quantitative label-free shotgun proteomics. A meth hetamine challenge resulted in a significant sensitized locomotor response in meth hetamine pretreated animals compared to saline controls. Proteomic analysis revealed 96 proteins that were differentially expressed in the PFC of meth hetamine treated rats, with 20% of these being previously implicated in the neurobiology of schizophrenia in the PFC. We identified multiple biological functions in the PFC that appear to be commonly altered across meth hetamine-induced sensitization and schizophrenia, and these include synaptic regulation, protein phosphatase signaling, mitochondrial function, and alterations to the inhibitory GABAergic network. These changes could inform how alterations to the PFC could underlie the cognitive and behavioral dysfunction commonly seen across psychoses and places such biological changes as potential mediators in the maintenance of psychosis vulnerability.
Publisher: Springer Berlin Heidelberg
Date: 2001
Publisher: Springer Berlin Heidelberg
Date: 2001
Publisher: Birkhäuser Boston
Date: 2005
Publisher: Springer Berlin Heidelberg
Date: 2012
Publisher: Springer Berlin Heidelberg
Date: 2009
Publisher: Springer International Publishing
Date: 2021
Publisher: Springer Science and Business Media LLC
Date: 10-2002
Publisher: Springer Berlin Heidelberg
Date: 2010
Publisher: Springer Berlin Heidelberg
Date: 2015
Publisher: World Scientific Pub Co Pte Lt
Date: 08-2003
DOI: 10.1142/S012905410300190X
Abstract: Hybrid dynamic systems include both continuous and discrete state variables. Properties of hybrid systems, which have an infinite state space, can often be verified using ordinary model checking together with a finite-state abstraction. Model checking can be inconclusive, however, in which case the abstraction must be refined. This paper presents a new procedure to perform this refinement operation for abstractions of hybrid systems. Following an approach originally developed for finite-state systems [11, 25], the refinement procedure constructs a new abstraction that eliminates a counterex le generated by the model checker. For hybrid systems, analysis of the counterex le requires the computation of sets of reachable states in the continuous state space. We show how such reachability computations with varying degrees of complexity can be used to refine hybrid system abstractions efficiently. Ex les illustrate our counterex le-guided refinement procedure. Experimental results for a prototype implementation indicate significant advantages over existing methods.
Publisher: Springer Berlin Heidelberg
Date: 2004
Publisher: Elsevier BV
Date: 10-2010
Publisher: Open Publishing Association
Date: 26-04-2020
DOI: 10.4204/EPTCS.316
Publisher: Springer Berlin Heidelberg
Date: 1998
Publisher: IEEE
Date: 12-2016
Publisher: Wiley
Date: 15-05-2014
DOI: 10.1111/BPH.12602
Publisher: ACM
Date: 21-10-2012
Publisher: Elsevier BV
Date: 06-2009
Publisher: Springer Berlin Heidelberg
Date: 2001
Publisher: Springer International Publishing
Date: 2021
Publisher: SCITEPRESS - Science and Technology Publications
Date: 2020
Publisher: Wiley
Date: 19-06-2013
DOI: 10.1002/CNE.23310
Abstract: Glucoprivation or hypoglycemia induces a range of counterregulatory responses, including glucose mobilization, reduced glucose utilization, and de novo glucose synthesis. These responses are mediated in part by the sympathetic nervous system. The aim of this study was to determine the chemical codes of sympathetic preganglionic neurons (SPN) activated by glucoprivation, induced by 2-deoxy-D-glucose (2DG). SPN controlling the adrenal glands and celiac ganglia, which ultimately can innervate the liver and pancreas, were targeted together with the superior cervical ganglia (control). 23.9% ± 1.3% of SPN in the T4-T11 region contained c-Fos immunoreactivity following 2DG 70.3% ± 1.8% of SPN innervating the adrenal glands and 37.4% ± 3% of SPN innervating celiac ganglia were activated. 14.8% ± 3.5% of SPN (C8-T3) innervating superior cervical ganglia were activated. In the C8-T3 region 55% ± 10% of SPN activated contained PPCART, with only 12% ± 3% expressing PPE mRNA, whereas, in the T4-T11 region, 78% ± 4% contained PPE, with only 6.0% ± 0.6% expressing PPCART mRNA. Thus CART is not involved in glucose mobilization. Two chemically distinct populations of SPN (PPE⁺ 57.4% ± 5%, PPE⁻ ∼40%) were identified to regulate adrenaline release in response to glucoprivation. Multiple chemically distinct SPN populations innervating a specific target could suggest their graded recruitment. The two distinct populations of SPN (PPE⁺ 67.6% ± 9%, PPE⁻ ∼30%) projecting to celiac ganglia activated by glucoprivation could direct pancreatic and hepatic or other counterregulatory responses. Nearly all SPN that expressed PPE mRNA and projected to the adrenal glands or celiac ganglia were activated, suggesting a role for the inhibitory peptide enkephalin in responses evoked by glucoprivation.
Publisher: Springer International Publishing
Date: 2013
Publisher: ACM
Date: 19-10-2020
Publisher: Springer Berlin Heidelberg
Date: 2006
DOI: 10.1007/11814764_12
Publisher: IEEE
Date: 09-2009
DOI: 10.1109/QEST.2009.37
Publisher: American Society for Pharmacology & Experimental Therapeutics (ASPET)
Date: 15-04-2011
Publisher: Springer Science and Business Media LLC
Date: 14-05-2014
DOI: 10.1038/NPP.2014.111
Publisher: Springer Nature Switzerland
Date: 2022
Publisher: Elsevier BV
Date: 10-2013
Publisher: Springer Berlin Heidelberg
Date: 2005
Publisher: Springer Science and Business Media LLC
Date: 06-2015
DOI: 10.1038/NMETH.3398
Publisher: Wiley
Date: 30-10-2013
DOI: 10.1111/JNC.12482
Abstract: Stress activates selected neuronal systems in the brain and this leads to activation of a range of effector systems. Our aim was to investigate some of the relationships between these systems under basal conditions and over a 40-min period in response to footshock stress. Specifically, we investigated catecholaminergic neurons in the locus coeruleus (LC), ventral tegmental area and medial prefrontal cortex (mPFC) in the brain, by measuring tyrosine hydroxylase (TH) protein, TH phosphorylation and TH activation. We also measured the effector responses by measuring plasma adrenocorticotrophic hormone, corticosterone, glucose and body temperature as well as activation of adrenal medulla protein kinases, TH protein, TH phosphorylation and TH activation. The LC, ventral tegmental area and adrenal medulla all had higher basal levels of Ser19 phosphorylation and lower basal levels of Ser31 phosphorylation than the mPFC, presumably because of their cell body versus nerve terminal location, while the adrenal medulla had the highest basal levels of Ser40 phosphorylation. Ser31 phosphorylation was increased in the LC at 20 and 40 min and in the mPFC at 40 min TH activity was increased at 40 min in both tissues. There were significant increases in body temperature between 10 and 40 min, as well as increases in plasma adrenocorticotropic hormone at 20 min and corticosterone and glucose at 20 and 40 min. The adrenal medulla extracellular signal-regulated kinase 2 was increased between 10 and 40 min and Ser31 phosphorylation was increased at 20 min and 40 min. Protein kinase A and Ser40 phosphorylation were increased only at 40 min. TH activity was increased between 20 and 40 min. TH protein and Ser19 phosphorylation levels were not altered in any of the brain regions or adrenal medulla over the first 40 min. These findings indicate that acute footshock stress leads to activation of TH in the LC, pre-synaptic terminals in the mPFC and adrenal medullary chromaffin cells, as well as changes in activity of the hypothalamic-pituitary-adrenal axis.
Publisher: Wiley
Date: 2015
DOI: 10.14814/PHY2.12246
Publisher: Springer International Publishing
Date: 2020
Publisher: Springer Berlin Heidelberg
Date: 2009
Publisher: Springer Science and Business Media LLC
Date: 30-08-2012
Publisher: Springer Berlin Heidelberg
Date: 1998
DOI: 10.1007/BFB0055334
Publisher: Springer Berlin Heidelberg
Date: 2007
Publisher: World Scientific Pub Co Pte Lt
Date: 08-2006
DOI: 10.1142/S0129054106004169
Abstract: Though model checking itself is a fully automated process, verifying correctness of a hybrid system design using model checking is not. This paper describes the necessary steps, and choices to be made, to go from an informal description of the problem to the final verification result for a formal model and requirement. It uses an automotive control system for illustration.
Publisher: Springer International Publishing
Date: 2018
Publisher: Springer Berlin Heidelberg
Date: 2009
Publisher: IEEE Comput. Soc
Date: 1999
Publisher: Elsevier BV
Date: 06-2003
Publisher: American Society for Pharmacology & Experimental Therapeutics (ASPET)
Date: 12-2008
DOI: 10.1124/PR.108.00802
Abstract: Identification of G protein-coupled receptors that are activated by free fatty acids has led to considerable interest in their pharmacology and function because of the wide range of normal physiology and disease states in which fatty acids have been implicated. Free fatty acid receptor (FFA) 1 is activated by medium- to long-chain fatty acids and is expressed in the insulin-producing beta-cells of the pancreas. Activation of FFA1 has been proposed to mediate fatty acid augmentation of glucose-stimulated insulin secretion although it is unclear whether the known long-term detrimental effects of beta-cell exposure to high levels of fatty acids are also mediated through this receptor. The related receptors FFA2 and FFA3 are both activated by short-chain fatty acids although they have key differences in the signaling pathways they activate and tissue expression pattern. The aim of this review is to provide a comprehensive overview of the current understanding of the pharmacology and physiological role of these fatty acid receptors.
Publisher: SAGE Publications
Date: 07-11-2013
Abstract: Impulsivity is characteristic of several mental health disorders and is largely mediated by the prefrontal cortex subregions: the medial prefrontal cortex (mPFC) and the orbitofrontal cortex (OFC). Dopamine (DA) and norepinephrine (NE) are known to modulate activity of the prefrontal cortex, however their direct role in impulsive choice is not known. The aim of the present study was to investigate the effect of microinjecting DA or NE compounds in the mPFC or OFC on impulsive choice as measured by a delayed reinforcement (DR) task in male Wistar Kyoto rats. Following training in the DR task, rats were pretreated with DA D 1 and D 2 receptor antagonists (SCH23390 3 μg/side, raclopride 3 or 6 μg/side) or NE α 1 and α 2 receptor agonists (phenylephrine 0.1 or 0.3 μg/side, guanfacine 1 or 3 μg/side, respectively) into the mPFC or OFC and the effect on impulsive behavior was assessed. Pretreatment with raclopride into the mPFC or OFC significantly increased impulsive choice, however only pretreatment with SCH23390 into the mPFC, and not the OFC, significantly increased impulsive choice. Pretreatment with the NE receptor agonists had no effect on impulsive choice. This study suggests that DA receptors, but not NE receptors, differentially mediate impulsive choice in sub-regions of the prefrontal cortex.
Publisher: Springer Berlin Heidelberg
Date: 2007
Publisher: Elsevier BV
Date: 10-2009
Publisher: Open Publishing Association
Date: 08-11-2015
DOI: 10.4204/EPTCS.196.5
Publisher: Wiley
Date: 25-08-2009
Publisher: IEEE
Date: 2003
Publisher: Springer Berlin Heidelberg
Date: 2003
Publisher: IEEE
Date: 09-2008
DOI: 10.1109/QEST.2008.32
Publisher: Springer Berlin Heidelberg
Date: 2012
Publisher: Springer Berlin Heidelberg
Date: 2012
Location: Australia
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Ansgar Fehnker.