ORCID Profile
0000-0002-1092-5715
Current Organisations
University of Queensland
,
University of Sydney
,
Wellington Hospital
,
Royal Australian College of General Practitioners
,
Queensland University of Technology
,
Royal Australasian College of Physicians
,
Australian College of Rural and Remote Medicine
,
James Cook University
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Publications
Homologous and heterologous re-challenge with Salmonella Typhi and Salmonella Paratyphi A in a randomised controlled human infection model
Publisher: Public Library of Science (PLoS)
Date: 20-10-2020
Clinical experience of intramuscular immunoglobulin for measles prophylaxis in children: Is it practical?
Publisher: Wiley
Date: 11-02-2020
DOI: 10.1111/JPC.14800
MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A
Publisher: Springer Science and Business Media LLC
Date: 17-01-2018
DOI: 10.1038/S41467-017-02540-X
Abstract: Mucosal-associated invariant T (MAIT) cells are innate-like T cells that can detect bacteria-derived metabolites presented on MR1. Here we show, using a controlled infection of humans with live Salmonella enterica serovar Paratyphi A, that MAIT cells are activated during infection, an effect maintained even after antibiotic treatment. At the peak of infection MAIT cell T-cell receptor (TCR)β clonotypes that are over-represented prior to infection transiently contract. Select MAIT cell TCRβ clonotypes that expand after infection have stronger TCR-dependent activation than do contracted clonotypes. Our results demonstrate that host exposure to antigen may drive clonal expansion of MAIT cells with increased functional avidity, suggesting a role for specific vaccination strategies to increase the frequency and potency of MAIT cells to optimize effector function.
Exserohilum infections in Australian Queensland children
Publisher: Wiley
Date: 06-11-2018
DOI: 10.1111/MYC.12864
Abstract: Exserohilum species are environmental moulds that can cause skin infection and sinusitis in both normal and immunosuppressed children. This study reviews paediatric cases of Exserohilum infection in Queensland, Australia, to identify the spectrum of disease and its clinical course. All culture-positive s les of Exserohilum species in children <18 years of age were identified from the Queensland Health Laboratory database (April 2003-April 2018). Clinical information was recorded from medical records. Eleven children were identified, and all had isolated Exserohilum rostratum. The mean age was 7.4 years (range 2.3-17.8) and 64% female. Four immunocompetent children (36%) had a skin infection (2/4), chronic sinusitis (1/4) or otitis externa (1/4). Seven children (64%) had an underlying oncological diagnosis with E. rostratum causing local skin infection (2/7), invasive rhinosinus disease (3/7) or disseminated infection (2/7). All oncological patients were empirically started on liposomal hotericin B with addition, or switch, to posaconazole or voriconazole. Exserohilum rostratum infection of the skin has a favourable course, whereas rhinosinus infection can be rapidly invasive in the immunocompromised child requiring prompt surgical intervention and antifungal therapy. Susceptibility data support empiric use of liposomal hotericin and/or posaconazole.
Publisher Correction: Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses.
Publisher: Springer Science and Business Media LLC
Date: 12-03-2019
DOI: 10.1038/S41590-019-0357-6
Abstract: In the version of this article initially published, the first affiliation lacked 'MRC' the correct name of the institution is 'MRC Weatherall Institute of Molecular Medicine'. Two designations (SP110Y and ST110H) were incorrect in the legend to Fig. 6f,h,i. The correct text is as follows: for panel f, "...loaded with either the CdtB(105-125)SP110Y (DRB4*SP110Y) or the CdtB(105-125)ST110H (DRB4*ST110H) peptide variants..." for panel h, "...decorated by the DRB4*SP110Y tetramer (lower-right quadrant), the DRB4*ST110H (upper-left quadrant)..." and for panel i, "...stained ex vivo with DRB4*SP110Y, DRB4*ST110H...". In Fig. 8e, the final six residues (LTEAFF) of the sequence in the far right column of the third row of the table were missing the correct sequence is 'CASSYRRTPPLTEAFF'. In the legend to Fig. 8d, a designation (HLyE) was incorrect the correct text is as follows: "(HlyE?)." Portions of the Acknowledgements section were incorrect the correct text is as follows: "This work was supported by the UK Medical Research Council (MRC) (MR/K021222/1) (G.N., M.A.G., A.S., V.C., A.J.P.),...the Oxford Biomedical Research Centre (A.J.P., V.C.),...and core funding from the Singapore Immunology Network (SIgN) (E.W.N.) and the SIgN immunomonitoring platform (E.W.N.)." Finally, a parenthetical element was phrased incorrectly in the final paragraph of the Methods subsection "T cell cloning and live fluorescence barcoding" the correct phrasing is as follows: "...(which in all cases included HlyE, CdtB, Ty21a, Quailes, NVGH308, and LT2 strains and in volunteers T5 and T6 included PhoN)...". Also, in Figs. 3c and 4a, the right outlines of the plots were not visible in the legend to Fig. 3, panel letter 'f' was not bold and in Fig. 8f, 'ND' should be aligned directly beneath DRB4 in the key and 'ND' should be removed from the diagram at right, and the legend should be revised accordingly as follows: "...colors indicate the HLA class II restriction (gray indicates clones for which restriction was not determined (ND)). Clonotypes are grouped on the basis of pathogen selectivity (continuous line), protein specificity (dashed line) and epitope specificity for ten HlyE-specific clones (pixilated squares), the epitope specificity was not determined...". The errors have been corrected in the HTML and PDF versions of the article.
Evaluation of the Clinical and Microbiological Response to Salmonella Paratyphi A Infection in the First Paratyphoid Human Challenge Model
Publisher: Oxford University Press (OUP)
Date: 04-02-2017
DOI: 10.1093/CID/CIX042
The role of Kingella kingae in pre-school aged children with bone and joint infections
Publisher: Elsevier BV
Date: 09-2021
Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses
Publisher: Springer Science and Business Media LLC
Date: 20-06-2018
DOI: 10.1038/S41590-018-0133-Z
Abstract: To tackle the complexity of cross-reactive and pathogen-specific T cell responses against related Salmonella serovars, we used mass cytometry, unbiased single-cell cloning, live fluorescence barcoding, and T cell-receptor sequencing to reconstruct the Salmonella-specific repertoire of circulating effector CD4
Inborn Errors of Immunity in Children With Invasive Pneumococcal Disease: A Multicenter Prospective Study
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 07-07-2023
DOI: 10.1097/INF.0000000000004004
Abstract: In settings with universal conjugate pneumococcal vaccination, invasive pneumococcal disease (IPD) can be a marker of an underlying inborn error of immunity. The aim of this study was to determine the prevalence and characterize the types of immunodeficiencies in children presenting with IPD. Multicenter prospective audit following the introduction of routinely recommended immunological screening in children presenting with IPD. The minimum immunological evaluation comprised a full blood examination and film, serum immunoglobulins (IgG, IgA and IgM), complement levels and function. Included participants were children in whom Streptococcus pneumoniae was isolated from a normally sterile site (cerebrospinal fluid, pleura, peritoneum and synovium). If isolated from blood, features of sepsis needed to be present. Children with predisposing factors for IPD (nephrotic syndrome, anatomical defect or malignancy) were excluded. Overall, there were 379 episodes of IPD of which 313 (83%) were eligible for inclusion and 143/313 (46%) had an immunologic evaluation. Of these, 17/143 (12%) were diagnosed with a clinically significant abnormality: hypogammaglobulinemia (n = 4), IgA deficiency (n = 3), common variable immunodeficiency (n = 2), asplenia (n = 2), specific antibody deficiency (n = 2), incontinentia pigmenti with immunologic dysfunction (n = 1), alternative complement deficiency (n = 1), complement factor H deficiency (n = 1) and congenital disorder of glycosylation (n = 1). The number needed to investigate to identify 1 child presenting with IPD with an immunologic abnormality was 7 for children aged under 2 years and 9 for those 2 years and over. This study supports the routine immune evaluation of children presenting with IPD of any age, with consideration of referral to a pediatric immunologist.
I Don't Have to be Sick to Still Be Worthy: The Barriers Experienced by Adolescent and Young Adult Cancer Survivors in New Zealand.
Publisher: Mary Ann Liebert Inc
Date: 02-08-2022
Understanding paratyphoid infection: study protocol for the development of a human model of Salmonella enterica serovar Paratyphi A challenge in healthy adult volunteers
Publisher: BMJ
Date: 16-06-2015
Antimicrobial Treatment Options for Granulomatous Mastitis Caused by Corynebacterium Species
Publisher: American Society for Microbiology
Date: 09-2015
DOI: 10.1128/JCM.00760-15
Abstract: Corynebacterium species are increasingly recognized as important pathogens in granulomatous mastitis. Currently, there are no published treatment protocols for Corynebacterium breast infections. This study describes antimicrobial treatment options in the context of other management strategies used for granulomatous mastitis. Corynebacterium spp. isolated from breast tissue and aspirate s les stored from 2002 to 2013 were identified and determined to the species level using matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS), 16S RNA sequencing, and rpoB gene targets. The MICs for 12 antimicrobials were performed using Etest for each isolate. Correlations of these with antimicrobial characteristics, choice of antimicrobial, and disease outcome were evaluated. Corynebacterium spp. from breast tissue and aspirate s les were confirmed in 17 isolates from 16 patients. Based on EUCAST breakpoints, Corynebacterium kroppenstedtii isolates ( n = 11) were susceptible to seven antibiotic classes but resistant to β-lactam antibiotics. Corynebacterium tuberculostearicum isolates ( n = 4) were multidrug resistant. Two nonlipophilic species were isolated, Corynebacterium glucuronolyticum and Corynebacterium freneyi , both of which have various susceptibilities to antimicrobial agents. Short-course antimicrobial therapy was common (median, 6 courses per subject range, 1 to 9 courses). Patients with C. kroppenstedtii presented with a hot painful breast mass and underwent multiple surgical procedures (median, 4 procedures range, 2 to 6 procedures). The management of Corynebacterium breast infections requires a multidisciplinary approach and includes culture and appropriate sensitivity testing to guide antimicrobial therapy. Established infections have a poor outcome, possibly because adequate concentrations of some drugs will be difficult to achieve in lipophilic granulomata. Lipophilic antimicrobial therapy may offer a therapeutic advantage. The role of immunotherapy has not been defined.
Development and Evaluation of a Blood Culture PCR Assay for Rapid Detection of Salmonella Paratyphi A in Clinical Samples
Publisher: Public Library of Science (PLoS)
Date: 03-2016
Impact of the COVID-19 nonpharmaceutical interventions on influenza and other respiratory viral infections in New Zealand
Publisher: Springer Science and Business Media LLC
Date: 12-02-2021
DOI: 10.1038/S41467-021-21157-9
Abstract: Stringent nonpharmaceutical interventions (NPIs) such as lockdowns and border closures are not currently recommended for pandemic influenza control. New Zealand used these NPIs to eliminate coronavirus disease 2019 during its first wave. Using multiple surveillance systems, we observed a parallel and unprecedented reduction of influenza and other respiratory viral infections in 2020. This finding supports the use of these NPIs for controlling pandemic influenza and other severe respiratory viral threats.
Diagnostic host gene signature for distinguishing enteric fever from other febrile diseases
Publisher: EMBO
Date: 30-08-2019
Diagnostic host gene signature to accurately distinguish enteric fever from other febrile diseases
Publisher: Cold Spring Harbor Laboratory
Date: 21-05-2018
DOI: 10.1101/327429
Abstract: Misdiagnosis of enteric fever is a major global health problem resulting in patient mismanagement, antimicrobial misuse and inaccurate disease burden estimates. Applying a machine-learning algorithm to host gene expression profiles, we identified a diagnostic signature which could accurately distinguish culture-confirmed enteric fever cases from other febrile illnesses (AUROC %). Applying this signature to a culture-negative suspected enteric fever cohort in Nepal identified a further 12.6% as likely true cases. Our analysis highlights the power of data-driven approaches to identify host-response patterns for the diagnosis of febrile illnesses. Expression signatures were validated using qPCR highlighting their utility as PCR-based diagnostic for use in endemic settings.
Technical Requirements and Approaches in Personal Data Control
Publisher: Association for Computing Machinery (ACM)
Date: 16-01-2023
DOI: 10.1145/3558766
Abstract: There has been a trend of moving from simply de-identification to providing extended data control to their owner (e.g., data portability and right to be forgotten), partly due to the introduction of the General Data Protection Regulation (GDPR). Hence, in this paper, we survey the literature to provide an in-depth understanding of the existing approaches for personal data control (e.g., we observe that most existing approaches are generally designed to facilitate compliance), as well as the privacy regulations in Europe, United Kingdom, California, South Korea, and Japan. Based on the review, we identify the associated technical requirements, as well as a number of research gaps and potential future directions (e.g., the need for transparent processing of personal data and establishment of clear procedure in ensuring personal data control).
Temporal associations of the COVID-19 related border restrictions and respiratory viral infections in New Zealand
Publisher: Research Square Platform LLC
Date: 14-12-2022
DOI: 10.21203/RS.3.RS-2352563/V1
Abstract: New Zealand (NZ)’s elimination of community transmission of influenza and respiratory syncytial virus (RSV) infections in May 2020, due to stringent COVID-19 countermeasures, provided a rare opportunity to assess the impact of border restrictions and relaxations on common respiratory viral infections over the subsequent two-years. Using multiple surveillance systems, we observed that border closure to most non-residents, and mandatory government-managed isolation and quarantine on arrival for those allowed to enter, appeared to be effective in keeping influenza and RSV infections out of the NZ community. Partial border relaxations through quarantine free travel with Australia and other countries were associated, within weeks, with importation of RSV and influenza into NZ in 2021 and 2022. Border restrictions did not have effect on community transmission of other respiratory viruses such as rhinovirus and parainfluenza virus type 1. These data can inform future pandemic influenza preparedness as well as provide insights into effective strategies to plan and model the impact of seasonal influenza, RSV, and other respiratory viral infections.
Time to first dose of antibiotics in febrile neonates.
Publisher: Wiley
Date: 31-03-2023
DOI: 10.1111/JPC.16375
Abstract: To assess whether febrile neonates from the community received their first dose of intravenous antibiotics within 1 h from time of arrival, as per the regional paediatric sepsis pathway, at a tertiary combined adult/child emergency department in New Zealand. Retrospective data were collected from January 2018 to December 2019 with 28 patients included. Mean time to first antibiotic dose for all neonates and those with serious bacterial infection was 3 h 20 min and 2 h 53 min respectively. No case used the paediatric sepsis pathway. A pathogen was identified in 19/28 (67%) neonates and 16/28 (57%) had clinical signs of shock. This study adds to Australasian data on community neonatal sepsis. Antibiotic administration was delayed for neonates with serious bacterial infection, clinical signs of shock and raised lactate. The reasons for delay are examined, with a number of potential areas for improvement identified.
Genetic Susceptibility to Enteric Fever in Experimentally Challenged Human Volunteers
Publisher: American Society for Microbiology
Date: 21-04-2022
DOI: 10.1128/IAI.00389-21
Abstract: Infections with Salmonella enterica serovars Typhi and Paratyphi A cause an estimated 14 million cases of enteric fever annually. Here, the controlled nature of challenge studies is exploited to identify genetic variants associated with enteric fever susceptibility.
Related Organisations
Royal Australian College Of General Practitioners
Location: Australia
Related Funding Activities
No related grants have been discovered for Hazel Dobinson.