ORCID Profile
0000-0002-5424-3927
Current Organisation
Telethon Kids Institute
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Publisher: JMIR Publications Inc.
Date: 21-04-2021
Abstract: mpowering young people with type 1 diabetes (T1D) to manage their blood glucose levels during exercise is a complex challenge faced by health care professionals due to the unpredictable nature of exercise and its effect on blood glucose levels. Mobile health (mHealth) apps would be useful as a decision-support aid to effectively contextualize a blood glucose result and take appropriate action to optimize glucose levels during and after exercise. A novel mHealth app acT1ve was recently developed, based on expert consensus exercise guidelines, to provide real-time support for young people with T1D during exercise. ur aim was to pilot acT1ve in a free-living setting to assess its acceptability and functionality, and gather feedback on the user experience before testing it in a larger clinical trial. prospective single-arm mixed method design was used. Ten participants with T1D (mean age 17.7 years, SD 4.2 years mean HbA sub c /sub , 54 mmol/mol, SD 5.5 mmol/mol [7.1%, SD 0.5%]) had acT1ve installed on their phones, and were asked to use the app to guide their exercise management for 6 weeks. At the end of 6 weeks, participants completed both a semistructured interview and the user Mobile Application Rating Scale (uMARS). All semistructured interviews were transcribed. Thematic analysis was conducted whereby interview transcripts were independently analyzed by 2 researchers to uncover important and relevant themes. The uMARS was scored for 4 quality subscales (engagement, functionality, esthetics, and information), and a total quality score was obtained from the weighted average of the 4 subscales. Scores for the 4 objective subscales were determined by the mean score of each of its in idual questions. The perceived impact and subjective quality of acT1ve for each participant were calculated by averaging the scores of their related questions, but were not considered in the total quality score. All scores have a maximal possible value of 5, and they are presented as medians, IQRs, and ranges. he main themes arising from the interview analysis were “increased knowledge,” “increased confidence to exercise,” and “suitability” for people who were less engaged in exercise. The uMARS scores for acT1ve were high (out of 5) for its total quality (median 4.3, IQR 4.2-4.6), engagement (median 3.9, IQR 3.6-4.2), functionality (median 4.8, IQR 4.5-4.8), information (median 4.6, IQR 4.5-4.8), esthetics (median 4.3, IQR 4.0-4.7), subjective quality (median 4.0, IQR 3.8-4.2), and perceived impact (median 4.3, IQR 3.6-4.5). he acT1ve app is functional and acceptable, with a high user satisfaction. The efficacy and safety of this app will be tested in a randomized controlled trial in the next phase of this study. ustralian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12619001414101 www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=378373
Publisher: JMIR Publications Inc.
Date: 02-08-2023
Abstract: anaging blood glucose levels around exercise is one of the most challenging tasks for young people living with type 1 diabetes (T1D). Innovative interventions that include decision-support aids are required to better support young people to effectively contextualize a blood glucose result and take appropriate action to optimize glucose levels during and after exercise. Mobile health (mHealth) tools are a useful platform to deliver health behaviour interventions for young people living with T1D, given the use of technology for glucose monitoring, insulin dosing and carbohydrate counting. he aim of this study was to develop a novel prototype mHealth application (app) to support exercise management for young people with T1D. co-design approach with a user-centred design thinking framework was used to develop a prototype mHealth app called “acT1ve”during the 18-month design process from March 2018 to September 2019. To better understand and respond to the challenges faced by young people with diabetes when physically active, ten focus groups were conducted with young people aged 13-25years living with T1D and parents of young people living with T1D. The next stage of development involved conducting participatory design workshops with young people to identify key features of the app that would support in idual needs when physically active. These features were incorporated into a wireframe, which was presented to participants for critical review. A beta version of “acT1Ve” was built in iOS and android operating systems which underwent critical review by consumers, clinicians, researchers, experts in exercise and T1D and app designers. ixty young people (13-25y) living with T1D, 14 parents of young people living with T1D, 6 researchers and 10 clinicians were engaged in the development of “acT1ve”. The acT1ve app included key features identified by the young people which would support their in idual needs when physically active. It provided carbohydrate and insulin advice during exercise, information on hypoglycaemia treatment, pre-and post-exercise advice, and an educational food guide in the context of exercise management. “acT1ve” contained an exercise advisor algorithm consisting of 240 pathways developed by experts in diabetes and exercise research. Based on participant input during exercise, acT1ve provided personalized insulin and carbohydrate advice for exercise lasting up to 60 minutes. The app is complemented by other features like an activity log which displays a complete record of the users’ activities and associated exercise advice provided by the app’s algorithm for later reference, and regular reminder notifications for users to check/monitor their glucose levels. he co-design approach and the practical application of the user-centred design thinking framework was successfully applied to develop “acT1ve”, an app to support exercise management for young people living with T1D.
Publisher: Wiley
Date: 13-02-2019
DOI: 10.1111/DME.13914
Abstract: To determine whether pre-exercise ingestion of carbohydrates to maintain stable glycaemia during moderate-intensity exercise results in excessive hyperglycaemia if combined with repeated sprints in in iduals with Type 1 diabetes. Eight overnight-fasted people with Type 1 diabetes completed the following four 40-min exercise sessions on separate days in a randomized counterbalanced order under basal insulinaemic conditions: continuous moderate-intensity exercise at 50% The difference in marginal mean time-averaged area under the blood glucose curve between continuous moderate-intensity exercise + prior carbohydrate and intermittent high-intensity exercise + prior carbohydrate during exercise and recovery was not significant [0.2 mmol/l (95% CI -0.7, 1.1) P = 0.635], nor was the difference in peak blood glucose level after adjusting for baseline level [0.2 mmol/l (95% CI -0.7, 1.1) P = 0.695]. The difference in marginal mean time-averaged area under the blood glucose curve between continuous moderate-intensity and intermittent high-intensity exercise during exercise and recovery was also not significant [-0.2 mmol/l (95% CI -1.2, 0.8) P = 0.651]. When carbohydrates are ingested prior to moderate-intensity exercise, adding repeated sprints is not significantly detrimental to glycaemic management in overnight fasted people with Type 1 diabetes under basal insulin conditions.
Publisher: JMIR Publications Inc.
Date: 14-10-2021
DOI: 10.2196/29739
Abstract: Empowering young people with type 1 diabetes (T1D) to manage their blood glucose levels during exercise is a complex challenge faced by health care professionals due to the unpredictable nature of exercise and its effect on blood glucose levels. Mobile health (mHealth) apps would be useful as a decision-support aid to effectively contextualize a blood glucose result and take appropriate action to optimize glucose levels during and after exercise. A novel mHealth app acT1ve was recently developed, based on expert consensus exercise guidelines, to provide real-time support for young people with T1D during exercise. Our aim was to pilot acT1ve in a free-living setting to assess its acceptability and functionality, and gather feedback on the user experience before testing it in a larger clinical trial. A prospective single-arm mixed method design was used. Ten participants with T1D (mean age 17.7 years, SD 4.2 years mean HbA1c, 54 mmol/mol, SD 5.5 mmol/mol [7.1%, SD 0.5%]) had acT1ve installed on their phones, and were asked to use the app to guide their exercise management for 6 weeks. At the end of 6 weeks, participants completed both a semistructured interview and the user Mobile Application Rating Scale (uMARS). All semistructured interviews were transcribed. Thematic analysis was conducted whereby interview transcripts were independently analyzed by 2 researchers to uncover important and relevant themes. The uMARS was scored for 4 quality subscales (engagement, functionality, esthetics, and information), and a total quality score was obtained from the weighted average of the 4 subscales. Scores for the 4 objective subscales were determined by the mean score of each of its in idual questions. The perceived impact and subjective quality of acT1ve for each participant were calculated by averaging the scores of their related questions, but were not considered in the total quality score. All scores have a maximal possible value of 5, and they are presented as medians, IQRs, and ranges. The main themes arising from the interview analysis were “increased knowledge,” “increased confidence to exercise,” and “suitability” for people who were less engaged in exercise. The uMARS scores for acT1ve were high (out of 5) for its total quality (median 4.3, IQR 4.2-4.6), engagement (median 3.9, IQR 3.6-4.2), functionality (median 4.8, IQR 4.5-4.8), information (median 4.6, IQR 4.5-4.8), esthetics (median 4.3, IQR 4.0-4.7), subjective quality (median 4.0, IQR 3.8-4.2), and perceived impact (median 4.3, IQR 3.6-4.5). The acT1ve app is functional and acceptable, with a high user satisfaction. The efficacy and safety of this app will be tested in a randomized controlled trial in the next phase of this study. Australian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12619001414101 www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=378373
Publisher: Wiley
Date: 16-11-2023
DOI: 10.1111/DME.15000
Abstract: To examine the within‐person variability in plasma glucose responses to moderate‐intensity morning exercise in young in iduals with type 1 diabetes after overnight fasting and under basal insulin conditions. In this pilot study, eight participants completed 40 min of moderate‐intensity exercise at 60% V̇O 2 peak on three separate days. The within‐person standard deviation (SDw) in plasma glucose response was analysed both during and 1 h after exercise using the two visits per participant most closely matched by pre‐exercise plasma glucose level. When the two closest matched visits per in idual were included for analysis, mean (±SD) change in plasma glucose level was −1.8 ± 1.1 mmoL/L during exercise and −0.6 ± 1.0 mmoL/L during recovery, with the SDw of these changes being 0.5 mmol (95% CI 0.2, 0.8) during exercise and 0.8 mmoL/L (95% CI 0.4, 1.3) during recovery. The median intra‐in idual difference in plasma glucose level change was 0.3 mmoL/L [IQR 0.1, 0.7] during exercise and 0.8 mmoL/L [IQR 0.4, 1.0] during recovery. Within‐person plasma glucose responses to moderate‐intensity exercise may be reproducible under fasting and basal insulin conditions and similar pre‐exercise plasma glucose levels. This finding may assist the design of future studies investigating both the reproducibility of glycaemic responses to exercise and blood glucose management for in iduals with type 1 diabetes.
Location: Australia
No related grants have been discovered for Wayne Soon.