ORCID Profile
0000-0002-4624-6415
Current Organisations
Australian National University
,
Shanghai University of Sport
,
Guangzhou Sport University
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Wiley
Date: 13-01-2022
DOI: 10.1111/AJE.12960
Abstract: Zombitse‐Vohibasia National Park harbours a species‐rich but understudied lemur community in southwestern Madagascar. Local population estimates are dated or absent for its four sympatric species of Cheirogaleidae: the grey mouse lemur ( Microcebus murinus ), Coquerel's giant mouse lemur ( Mirza coquereli ), fat‐tailed dwarf lemur ( Cheirogaleus medius ) and pale fork‐marked lemur ( Phaner pallescens ). To provide local density and encounter rate estimates for these cheirogaleids, we conducted line transect surveys in the Zombitse sector of the National Park over a three‐week period in December 2018–January 2019. We calculated densities of 37.4 Mir. coquereli in iduals/km 2 (95% CI = 20.4–68.6) and 230.8 C. medius in iduals/km 2 (95% CI = 172.6–308.6). Our results highlight the conservation importance of Zombitse‐Vohibasia as a stronghold for these restricted and threatened species. The s le sizes for Mic. murinus and P. pallescens were insufficient for generating population estimates. Considering that Microcebus spp. are typically amongst the most abundant mammals at a given site, further studies are needed to investigate and verify this apparent scarcity.
Publisher: Wiley
Date: 20-10-2019
DOI: 10.1002/JCP.27385
Abstract: Excessive osteoclast formation and function are considered as the main causes of bone lytic disorders such as osteoporosis and osteolysis. Therefore, the osteoclast is a potential therapeutic target for the treatment of osteoporosis or other osteoclast‐related diseases. Helvolic acid (HA), a mycotoxin originally isolated from Aspergillus fumigatus , has been discovered as an effective broad‐spectrum antibacterial agent and has a wide range of pharmacological properties. Herein, for the first time, HA was demonstrated to be capable of significantly inhibiting receptor activator of nuclear factor‐κB ligand (RANKL)‐induced osteoclastogenesis and bone resorption in vitro by suppressing nuclear factor of activated T cells 1 (NFATc1) activation. This inhibition was followed by the dramatically decreased expression of NFATc1‐targeted genes including Ctr (encoding calcitonin receptor), Acp5 (encoding tartrate‐resistant acid phosphatase [TRAcP]), Ctsk (encoding cathepsin K), Atp6v0d2 (encoding the vacuolar H+ ATPase V0 subunit d2 [V‐ATPase‐d2]) and Mmp9 (encoding matrix metallopeptidase 9) which are osteoclastic‐specific genes required for osteoclast formation and function. Mechanistically, HA was shown to greatly attenuate multiple upstream pathways including extracellular signal‐regulated kinase (ERK) phosphorylation, c‐Fos signaling, and intracellular Ca 2+ oscillation, but had little effect on nuclear factor‐κB (NF‐κB) activation. In addition, HA also diminished the RANKL‐induced generation of intracellular reactive oxygen species. Taken together, our study indicated HA effectively suppressed RANKL‐induced osteoclast formation and function. Thus, we propose that HA can be potentially used in the development of a novel drug for osteoclast‐related bone diseases.
Publisher: Brill
Date: 14-02-2021
DOI: 10.1159/000512559
Abstract: Estimates of population size are fundamental to setting conservation priorities for threatened primate species. Many taxa in the lemur genus Lepilemur remain understudied, and basic population statistics are often dated, incomplete, or absent. Hubbard’s sportive lemur ( Lepilemur hubbardorum ) is known only from the Zombitse-Vohibasia National Park region in southwestern Madagascar. It is listed as Endangered by the IUCN owing to its fragmented, declining habitat and limited geographic range. However, this classification has not been confirmed through systematic population estimates. To address this issue, we undertook line transect surveys in the Zombitse parcel of the National Park. We applied geospatial analyses and data to quantify forest area as a proxy for L . hubbardorum habitat. We recorded a total of 234 L. hubbardorum sightings over 18 survey nights, representing 47.2 km of survey effort. Our surveys revealed population densities of 145.6 L. hubbardorum in iduals per km 2 (95% CI: 97.2–218.1), for an extrapolated abundance estimate of ca. 16,500–18,000 L. hubbardorum in iduals across the protected forests of the Zombitse parcel. This abundance estimate should be considered provisional, however, because our restricted s ling area did not include the more remote regions of the National Park where habitat disturbance and hunting practices have likely contributed to localized population declines.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 14-03-2023
Publisher: Wiley
Date: 05-04-2021
DOI: 10.1002/AJP.23256
Publisher: Frontiers Media SA
Date: 29-11-2021
DOI: 10.3389/FPHYS.2021.736108
Abstract: In prolonged intense exercise training, the training load of athletes may be reduced once their hemoglobin concentrations ([Hb]s) are decreased dramatically. We previously reported that intermittent hypoxia exposure (IHE) could be used to alleviate the decrease of [Hb] and help to maintain the training load in rats. To further explore the feasibility of applying IHE intervention to athletes during prolonged intense exercise training, 6 trained swimmers were recruited to conduct a 4-week IHE intervention at the intervals after their [Hb] dropped for 10% or more during their training season. IHE intervention lasted 1 h and took place once a day and five times a week. Hematological and hormonal parameters, including [Hb], red blood cells (RBC), hematocrit (Hct), reticulocytes, serum erythropoietin (EPO), testosterone (T) and cortisol (C) were examined. After the IHE intervention was launched, [Hb], RBC and Hct of the subjects were increased progressively with their maximum levels ( P & 0.01) showing at the third or fourth week, respectively. An increase in reticulocyte count ( P & 0.01) suggests that IHE intervention promotes erythropoiesis to increase [Hb]. Besides, serum level of EPO, the hormone known to stimulate erythropoiesis, was overall higher than that before the IHE intervention, although it was statistically insignificant. Furthermore, the serum level of T, another hormone known to stimulate erythropoiesis, was increased progressively with the maximum level showing at the fourth week. Collectively, this study further confirms that IHE intervention may be used as a new strategy to prevent intense exercise training-induced reductions in [Hb].
Publisher: Cambridge University Press (CUP)
Date: 04-2009
DOI: 10.1017/S1744133109004836
Abstract: Although access to health care is frequently identified as a goal for health care policy, the precise meaning of access to health care often remains unclear. We present a conceptual framework that defines access to health care as the empowerment of an in idual to use health care and as a multidimensional concept based on the interaction (or degree of fit) between health care systems and in iduals, households, and communities. Three dimensions of access are identified: availability, affordability, and acceptability, through which access can be evaluated directly instead of focusing on utilisation of care as a proxy for access. We present the case for the comprehensive evaluation of health care systems as well as the dimensions of access, and the factors underlying each dimension. Such systemic analyses can inform policy-makers about the ‘fit’ between needs for health care and receipt of care, and provide the basis for developing policies that promote improvements in the empowerment to use care.
No related grants have been discovered for Luke Martin.