ORCID Profile
0000-0001-6949-4019
Current Organisation
Curtin University
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Research Topics
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Top 5 Research Topics
ANZSRC Field of Research (FoR)
Physical Chemistry (Incl. Structural) | Structural Chemistry and Spectroscopy | Organometallic Chemistry | Other Chemical Sciences | Inorganic Chemistry | Plant Cell and Molecular Biology | Condensed Matter Physics | Organic Chemical Synthesis | Analytical Spectrometry | Immunological and Bioassay Methods | Non-automotive Combustion and Fuel Engineering (incl. Alternative/Renewable Fuels) | Chemical Characterisation of Materials | Plant Biology | Biochemistry and Cell Biology not elsewhere classified | Systems Biology | Animal Neurobiology | Nanotechnology | Fish Physiology and Genetics | Photonics, Optoelectronics and Optical Communications | Nonlinear Optics and Spectroscopy | Biomaterials | Medical Physiology | Bioinorganic Chemistry | F-Block Chemistry | F-Block Chemistry | Systems Physiology | Nanoscale Characterisation | Infectious Agents | Nanomaterials | Crop and Pasture Biochemistry and Physiology | Materials Engineering Not Elsewhere Classified | Cellular Nervous System | Electronic and Magnetic Properties of Condensed Matter; Superconductivity
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences | Expanding Knowledge in Technology | Plant Production and Plant Primary Products not elsewhere classified | Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified | Neurodegenerative Disorders Related to Ageing | Production of Biofuels (Biomass) | Chemical sciences | Fisheries - Wild Caught not elsewhere classified | Integrated Circuits and Devices | Other | Winter Grains and Oilseeds not elsewhere classified | Diagnostic Methods | Expanding Knowledge in the Physical Sciences | Environment not elsewhere classified |
Related Links
Publications
Colloidal quasi-one-dimensional dual semiconductor core/shell nanorod couple heterostructures with blue fluorescence
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9NR02443C
Abstract: ZnS (short arms)–ZnSe (long arms)/ZnS shell nanorod couple heterostructures was prepared and over-coated by a CdS layer to generate blue emission.
Diol-functionalised benzoates as novel linkers for the formation of coordination polymers
Publisher: Royal Society of Chemistry (RSC)
Date: 2007
DOI: 10.1039/B616939B
Defining the Anti‐Cancer Activity of Tricarbonyl Rhenium Complexes: Induction of G2/M Cell Cycle Arrest and Blockade of Aurora‐A Kinase Phosphorylation
Publisher: Wiley
Date: 12-04-2017
Abstract: Rhenium and ruthenium complexes containing N-heterocylic carbene (NHC) ligands and conjugated to indomethacin were prepared. The anticancer properties were probed against pancreatic cell lines, revealing a remarkable activity of the rhenium fragment as anticancer agent. The ruthenium complexes were found to be inactive against the same pancreatic cancer cell lines, either alone or in conjugation with indomethacin. An in-depth biological study revealed the origin of the anticancer properties of the rhenium tricarbonyl fragment, of which a complete elucidation had yet to be achieved. It was found that the rhenium complexes induce cell cycle arrest at the G2/M phase by inhibiting the phosphorylation of Aurora-A kinase. A preliminary study on the structure-activity relationship on a large family of these complexes revealed that the anticancer properties are mainly associated with the lability of the ancillary ligand, with inert complexes showing limited to no anticancer properties.
Hydrated Lanthanoid Complexes of 5-(2′-Pyridyl)tetrazole Formed in the Presence of Dimethyl Sulfoxide
Publisher: CSIRO Publishing
Date: 2012
DOI: 10.1071/CH12031
Abstract: Reaction of DMSO solvates of lanthanoid nitrates or perchlorates with 5-(2′-pyridyl)tetrazole (pytz) and triethylamine in organic solvents resulted in the unexpected crystallization of hydrates, rather than DMSO solvates. This was confirmed by the structural characterization of [Eu(pytz)3(H2O)3]. Decreasing the metal:ligand ratio in the reaction mixture resulted in the crystallization of a complex salt formulated as [Y(pytz)2(H2O)4](pytz)·(Hpytz)·4H2O once again DMSO was absent from the product. Interestingly, the omission of base from one reaction resulted in the serendipitous crystallization of Hpytz in a zwitterionic form, unlike the neutral ligand structure reported previously.
Imaging nuclear, endoplasmic reticulum and plasma membrane events in real time
Publisher: Wiley
Date: 09-2016
Abstract: Live cell imaging can provide important information on cellular dynamics however, the full utilisation of this technology has been h ered by the limitations of imaging reagents. Metal-based complexes have the potential to overcome many of the issues common to many current imaging agents. The rhenium (I)-based complex fac-[Re(CO)3 (1,10-phenanthroline)(4-pyridyltetrazolate)], herein referred to as ReZolve-ER(™) , shows promise as a live cell imaging agent with rapid cell uptake, low cytotoxicity, resistance to photobleaching and compatibility with multicolour imaging. ReZolve-ER(™) localised to the nuclear membrane/endoplasmic reticulum (ER) and allowed the detection of exocytotic events at the plasma membrane. Thus, we present a new imaging agent for monitoring live cell events in real time, which is ideal for imaging either short- or long-time courses.
Enhanced Near-Infrared Emission from Eight-Coordinate vs Nine-Coordinate YbIII Complexes Using 2-(5-Methylpyridin-2-yl)-8-hydroxyquinoline
Publisher: American Chemical Society (ACS)
Date: 30-10-2020
A study of the formation and application of new chiral water soluble lanthanoid benzoates using real-time infrared spectroscopy
Publisher: Elsevier BV
Date: 05-2010
Photophysical and photochemical studies of tricarbonyl rhenium(i ) N-heterocyclic carbene complexes containing azide and triazolate ligands
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C5NJ03301B
Abstract: Rhenium NHC complexes bound to azide anions readily react with alkynes to form the corresponding triazolate complexes, a new class of photochemically active species.
Imaging lipophilic regions in rodent brain tissue with halogenated BODIPY probes
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0AN00099J
Abstract: Halogenated BODIPY probes allow lipid imaging in brain tissue with different level of specificity for the white matter that are linked to the chemical identity of the halogen substituent.
Synthesis and characterisation of homoleptic 2,9-diaryl-1,10-phenanthroline copper(i) complexes: Influencing selectivity in photoredox-catalysed atom-transfer radical addition reactions
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8DT04116D
Abstract: Novel bis(2,9-diaryl-1,10-phenanthroline)copper( i ) complexes were prepared to study a photoredox-catalysed reaction.
Luminescent Copolymer‐Rhenium(I) Hybrid Materials via Picolylamine‐Modified Poly(pentafluorophenyl acrylate)
Publisher: Wiley
Date: 25-06-2020
Well‐Defined Tetrazole‐Functional Copolymers as Macromolecular Ligands for Luminescent Ir(III) and Re(I) Metal Species: Synthesis, Photophysical Properties and Application in Bioimaging
Publisher: Wiley
Date: 03-05-2022
Abstract: Well‐defined copolymers containing luminescent iridium and hybrid iridium/rhenium fragments are prepared utilizing parent poly( n ‐butyl acrylamide‐ co ‐ N ‐(1 H ‐tetrazol‐5‐yl) acrylamide) as macromolecular chelating species. The parent (co)polymers are prepared via the modification of a precursor poly(pentafluorophenyl acrylate) (polyPFPA) homopolymer, prepared by reversible addition‐fragmentation chain transfer polymerization, with n ‐butylamine and 5‐aminotetrazole. Reaction of the parent copolymers with [Ir 2 (ppy) 4 ( μ −Cl 2 )] (ppy = 2‐phenylpyridine) yields modified copolymers containing the Ir(ppy) 2 fragment as a pendent group. Attachment of the Ir species is confirmed by a combination of photophysical studies, UV–Vis spectroscopy, and visually under irradiation with UV light. Importantly, it is demonstrated that the chelation of the Ir(ppy) 2 fragment to a polymeric scaffold does not impact the fundamental photophysical properties of the Ir species. Attachment of a second luminescent metal species, Re(CO) 3 (phen) (phen = 1,10‐phenanthroline), gives hybrid materials containing Re(I) and Ir(III). The photophysical properties of these hybrid materials are consistent with the presence of both metal species and indicate the occurrence of energy transfer phenomena from the polymer‐bound Ir to Re metal centers. Finally, it is demonstrated that the Ir modified polymers and the Ir/Re hybrid materials offer potential in tissue imaging applications with scope to tune both luminescent properties and biological specificity as evidenced from preliminary brain tissue staining experiments.
Synthesis and structural, redox and photophysical properties of tris-(2,5-di(2-pyridyl)pyrrolide) lanthanide complexes
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9DT01262A
Abstract: Nine-coordinate tris(dipyridylpyrrolide)lanthanide( iii ) complexes were readily obtained, and were investigated by X-ray crystallography, NMR spectroscopy, and photophysical and electrochemical studies.
(η4-Tetrafluorobenzobarrelene)-η1-((tri-4-fluorophenyl)phosphine)-η1-(2-phenylphenyl)rhodium(I): A Catalyst for the Living Polymerization of Phenylacetylenes
Publisher: American Chemical Society (ACS)
Date: 23-06-2021
Investigation of the structure and magnetism in lanthanide β-triketonate tetranuclear assemblies
Publisher: Informa UK Limited
Date: 05-05-2016
Influence of the Para-Substituent in Lanthanoid Complexes of Bistetrazole Substituted Calix[4]arenes
Publisher: American Chemical Society (ACS)
Date: 06-08-2019
DOI: 10.26434/CHEMRXIV.9255209.V1
Abstract: 5,11,17,23-Tetra-tert-butyl-25,27-dihydroxy-26,28-bis(tetrazole-5-ylmethoxy)calix[4]arene has been reported to form remarkable Ln19 and Ln12 elongated clusters, upon addition of aqueous ammonium carboxylates. The impact of the para substituent on lanthanoid cluster formation has been studied by synthesising two new bis-tetrazole calixarenes, with p -H, and p -allyl substituents. Solution phase dynamic light scattering measurements of the reaction mixtures indicated that clusters are not formed with the p -H and p -allyl derivatives, in contrast with the behaviour of the t- butyl analogue. Lanthanoid complexes of the p -H and p -allyl calixarenes were characterised by single crystal X-ray diffraction, and were found to form mononuclear complexes, linked to form a one-dimensional coordination polymer for the p -allyl system. All of the complexes were isolated as ammonium salts, with ammonium cation included in the calixarene cavity in most cases. It is concluded that the nature of the para substituent has a profound impact on the lanthanoid cluster formation process, and derivatives with more subtle structural changes will be required to determine if additional lanthanoid “bottlebrush” clusters can be isolated.
Photophysical and biological investigation of phenol substituted rhenium tetrazolato complexes
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9DT02198A
Abstract: Rhenium tetrazolato complexes appended to phenol substituents are exploited for cell labelling.
Synthesis and the photophysical and biological properties of tricarbonyl Re(i ) diimine complexes bound to thiotetrazolato ligands
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D2DT03237F
Abstract: The structure, stability, composition, photochemistry, and biological properties of twelve rhenium tris-carbonyl diamine complexes containing tautomeric thiotetrazolato ligands have been examined for their use as potential bio-imaging agents.
Time to onset of gastrointestinal bleeding in the SUP‐ICU trial: A pre‐planned substudy
Publisher: Wiley
Date: 11-09-2019
DOI: 10.1111/AAS.13459
Abstract: The aetiology and risk factors for clinically important gastrointestinal bleeding (CIB) in adult ICU patients may differ according to the onset of CIB, which could affect the balance between benefits and harms of stress ulcer prophylaxis (SUP). We assessed the time to CIB in the Stress Ulcer Prophylaxis in the Intensive Care Unit (SUP-ICU) trial. We assessed if associations between baseline characteristics including allocation to SUP and CIB changed during time in the ICU, specifically in the later (after day 2) compared to the earlier (first 2 days) period, using Cox models adjusted for SAPS II and allocation to SUP. Additionally, we described baseline characteristics and CIB episodes stratified by earlier/later/no CIB and 90-day mortality status. Clinically important gastrointestinal bleeding occurred in 110/3291 (3.3%) patients after a median of 6 (interquartile range 2-13) days 25.5% of the episodes occurred early. Higher SAPS II was consistently associated with increased risk of CIB (hazard ratio (HR) 1.03, 95% confidence interval (CI) 1.01-1.05 in the earlier period vs HR 1.02, 95% CI 1.01-1.03 in the later period P = .37) university hospital admission was associated with decreased risk of earlier CIB (HR 0.30, 95% CI 0.14-0.63) this significantly increased in the later period (to HR 0.85, 95% CI 0.53-1.37 P = .02). Patients with later compared to earlier CIB received more transfusions and had more diagnostic/therapeutic procedures for CIB. Clinically important gastrointestinal bleeding mostly occurred more than 2 days after randomization. University hospital admission was associated with significantly decreased risk of CIB in the earlier period only.
New tetrazole-based Cu(i ) homo- and heteroleptic complexes with various P^P ligands: synthesis, characterization, redox and photophysical properties
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C2DT32056H
Abstract: Four Cu(I) complexes with general formulas [Cu(N^N)(2)][BF(4)] and [(P^P)Cu(N^N)][BF(4)] were prepared, where N^N stands for 2-(2-tert-butyl-2H-tetrazol-5-yl)pyridine and P^P is a chelating diphosphine, namely bis-(diphenylphosphino)methane (dppm), bis-(diphenylphosphino)ethane (dppe) or bis[2-(diphenylphosphino)phenyl]ether (POP). In an acetonitrile medium, the Electro-Spray Ionization Mass Spectrometry (ESI-MS) determination provided the preliminary evidence for the occurrence of the dppm-containing complex as a mixture of a cationic mononuclear [Cu(N^N)(dppm)](+) species and a bis-cationic dinuclear [Cu(2)(N^N)(2)(dppm)(2)](2+)-type compound. Definitive evidence of peculiar structural features came from X-ray crystallography, which showed both the dppm- and, unexpectedly, the dppe-based heteroleptic compounds to crystallize as diphosphine-bridged Cu(I) dimers, unlike [Cu(N^N)(2)](+) and [(POP)Cu(N^N)](+) which are mononuclear species. In solutions of non-coordinating solvents, (31)P NMR studies at variable temperatures and dilution titrations confirmed that the dppm-based complex undergoes a monomer-dimer dynamic equilibrium, while the dppe-containing complex occurs as the bis-cationic dinuclear species, [Cu(2)(N^N)(2)(dppe)(2)](2+), within a concentration range comprised between 10(-2) and 10(-4) M. Differences among heteroleptic complexes might be related to the smaller natural bite angle displayed by dppm and dppe phosphine ligands (72° and 85°, respectively), with respect to that reported for POP (102°). The electrochemical features of the new species have been investigated by cyclic voltammetry. Despite the irreversible and complicated redox behaviour, which is typical for copper complexes, the reductions have been attributed to the tetrazole ligand whereas the oxidations are characterized as Cu(I/II) processes with a substantial contribution from the P^P-based ligands in the case of the heteroleptic species. All the four complexes are weakly or not luminescent in CH(2)Cl(2) solution, but heteroleptic complexes are bright green luminophores in a solid matrix, with quantum yields as high as 45% (dppm complex) even at room temperature. This makes them potential candidates as cheap emitting materials for electroluminescent devices.
Unravelling the Mechanism of Excited-State Interligand Energy Transfer and the Engineering of Dual Emission in [Ir(C
Publisher: American Chemical Society (ACS)
Date: 14-01-2020
DOI: 10.1021/ACS.INORGCHEM.9B03003
Abstract: Fundamental insights into the mechanism of triplet-excited-state interligand energy transfer dynamics and the origin of dual emission for phosphorescent iridium(III) complexes are presented. The complexes [Ir(C
Structural characterisation and photophysical properties of lanthanoid complexes of a tetra-amide functionalised calix[4]arene
Publisher: Informa UK Limited
Date: 29-01-2016
Lanthanoid Complexes Supported by Retro-Claisen Condensation Products of β-Triketonates
Publisher: American Chemical Society (ACS)
Date: 22-10-2018
DOI: 10.26434/CHEMRXIV.6448253.V4
Abstract: β -Triketonates have been recently used as chelating ligands for lanthanoid ions, presenting unique structures varying from polynuclear assemblies to polymers. In an effort to overcome low solubility of the complexes of tribenzoylmethane, four β -triketones with higher lipophilicity were synthesised. Complexation reactions were performed for each of these molecules using different alkaline bases in alcoholic media. X-ray diffraction studies suggested that the ligands were undergoing decomposition under the reaction conditions. This is proposed to be caused by in situ retro-Claisen condensation reactions, consistent with two ex les that have been reported previously. The lability of the lanthanoid cations in the presence of a varying set of potential ligands gave rise to structures where one, two, or three of the molecules involved in the retro-Claisen condensationreaction were linked to the lanthanoid centres. These results, along with measurements of ligand decomposition in the presence of base alone, suggest that using solvents of lower polarity will mimimise the impact of the retro-Claisen condensation in these complexes.
Afferent Neural Branching at Human Acupuncture Points: Do Needles Stimulate or Inhibit?
Publisher: Mary Ann Liebert Inc
Date: 03-2012
Rh(I)(2,5-norbornadiene)(biphenyl)(tris(4-fluorophenyl)phosphine): Synthesis, Characterization, and Application as an Initiator in the Stereoregular (Co)Polymerization of Phenylacetylenes
Publisher: American Chemical Society (ACS)
Date: 24-12-2019
DOI: 10.1021/ACSMACROLETT.9B00975
Abstract: The synthesis of the Rh(I)-aryl complex, Rh(I)(nbd)(BiPh)(P(4-FC
Di[2,6-bis(5-phenylpyrazol-3-yl)pyridine]Co(II): an old coordination mode for a novel supramolecular assembly
Publisher: Royal Society of Chemistry (RSC)
Date: 2010
DOI: 10.1039/C0CE00036A
Fully Ir(iii ) tetrazolate soft salts: the road to white-emitting ion pairs
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C5DT04958J
Abstract: The first ex les of anionic Ir( iii ) bis-tetrazolate complexes and their combination with a cationic Ir( iii )tetrazole derivative forming “fully tetrazolate” Ir( iii ) based soft salts as O 2 -sensitive white emitters are described herein.
Complementary Approaches to Imaging Subcellular Lipid Architectures in Live Bacteria Using Phosphorescent Iridium Complexes and Raman Spectroscopy
Publisher: Wiley
Date: 11-07-2019
Abstract: A family of three neutral iridium(III) tetrazolato complexes are investigated as bacterial imaging agents. The complexes offer a facile tuning of the emission colour from green (520 nm) to red (600 nm) in aqueous media, while keeping the excitation wavelength unchanged. The three complexes do not inhibit the bacterial growth of Bacillus Cereus, used as a model in this study, and exhibit extremely fast cellular uptake. After a minute incubation time, the nontoxic complexes show subcellular localisation in spherical structures identified as lipid vacuoles. Confocal Raman imaging has been exploited for the first time on live bacteria, to provide direct and label-free mapping of the lipid-enriched organelles within B. cereus, complementing the use of luminescent probes. Examination of the Raman spectra not only confirmed the presence of lipophilic inclusions in B. cereus but offered additional information about their chemical composition, suggesting that the lipid vacuoles may contain polyhydroxybutyrate (PHB).
Lanthanoid Complexation by a Tris‐Tetrazole‐Functionalised Calix[4]arene
Publisher: Wiley
Date: 28-10-2016
Introducing a New Family of Biotinylated Ir(III)-Pyridyltriazole Lumophores: Synthesis, Photophysics, and Preliminary Study of Avidin-Binding Properties
Publisher: American Chemical Society (ACS)
Date: 07-10-2014
DOI: 10.1021/OM5007962
Rhodium(I)‐α‐Phenylvinylfluorenyl Complexes: Synthesis, Characterization, and Evaluation as Initiators in the Stereospecific Polymerization of Phenylacetylene
Publisher: Wiley
Date: 08-01-2019
Metal Complexes as a Promising Source for New Antibiotics
Publisher: American Chemical Society (ACS)
Date: 15-10-2019
DOI: 10.26434/CHEMRXIV.9956744.V1
Abstract: There is a dire need for new classes of antimicrobial compounds to combat the growing threat of widespread antibiotic resistance. With a currently very scarce drug pipeline, consisting mostly of derivatives of known antibiotics, new classes of antibiotics are urgently required. Antibiotic compounds are notorious for not having very “drug-like” chemical structures. Metal complexes are currently in clinical development for the treatment of cancer, malaria and neurodegenerative diseases. However, only little attention has been paid to their application as potential antimicrobial compounds. We report the evaluation of 906 metal-containing compounds that have been screened by the Community for Open Antimicrobial Drug Discovery (CO-ADD) for antimicrobial activity. Metal-bearing compounds display a significantly higher hit-rate (9.9%) when compared to the purely organic molecules (0.87%) in the CO-ADD database. Out of 906 compounds, 88 show activity against at least one of the tested strains, including fungi, while not displaying any cytotoxicity against mammalian cell lines or haemolytic properties. Herein, we highlight the structures of the 30 compounds with activity against Gram-positive and/or Gram-negative bacteria containing Mn, Co, Zn, Ru, Ag, Eu, Ir and Pt, with activities down to the nanomolar range against methicillin resistant S. aureus (MRSA). This work reveals the vast ersity that metal-containing compounds can bring to antimicrobial research. It is important to raise awareness of these types of compounds for the design of truly novel antibiotics with potential for combatting antimicrobial resistance.
Pharmacological and structure-activity relationship studies of oleoyl-lysophosphatidylinositol synthetic mimetics
Publisher: Elsevier BV
Date: 10-2021
Metal Complexes as a Promising Source for New Antibiotics
Publisher: American Chemical Society (ACS)
Date: 22-10-2019
DOI: 10.26434/CHEMRXIV.9956744.V2
Abstract: There is a dire need for new classes of antimicrobial compounds to combat the growing threat of widespread antibiotic resistance. With a currently very scarce drug pipeline, consisting mostly of derivatives of known antibiotics, new classes of antibiotics are urgently required. Antibiotic compounds are notorious for not having very “drug-like” chemical structures. Metal complexes are currently in clinical development for the treatment of cancer, malaria and neurodegenerative diseases. However, only little attention has been paid to their application as potential antimicrobial compounds. We report the evaluation of 906 metal-containing compounds that have been screened by the Community for Open Antimicrobial Drug Discovery (CO-ADD) for antimicrobial activity. Metal-bearing compounds display a significantly higher hit-rate (9.9%) when compared to the purely organic molecules (0.87%) in the CO-ADD database. Out of 906 compounds, 88 show activity against at least one of the tested strains, including fungi, while not displaying any cytotoxicity against mammalian cell lines or haemolytic properties. Herein, we highlight the structures of the 30 compounds with activity against Gram-positive and/or Gram-negative bacteria containing Mn, Co, Zn, Ru, Ag, Eu, Ir and Pt, with activities down to the nanomolar range against methicillin resistant S. aureus (MRSA). This work reveals the vast ersity that metal-containing compounds can bring to antimicrobial research. It is important to raise awareness of these types of compounds for the design of truly novel antibiotics with potential for combatting antimicrobial resistance.
Investigation of the Photophysical Properties of a Eu3+ Coordination Polymer Bearing an α-Nitrile Substituted β-Diketonate Ligand via Emission and Ultrafast Transient Absorption Spectroscopy
Publisher: CSIRO Publishing
Date: 2015
DOI: 10.1071/CH15253
Abstract: Reaction of the β-diketone ligand, 2-cyano-1,3-phenyl-1,3-propandione (LH), with hydrated EuCl3 in the presence of 1,10-phenanthroline (Phen), results in the crystallisation of a one-dimensional Eu3+ coordination polymer of formulation [Eu(Phen)(L)3]∞, formed by coordination of the nitrile group of an O,O′-bound ligand to a neighbouring metal centre. An investigation of the metal-centred emission of the polymer, both in the solid state and solution, revealed red emission characterised by relatively long-lived excited state lifetimes and high intrinsic quantum yields. However, analysis of the overall quantum yield and sensitisation efficiency reveals that ultrafast processes in the ligand potentially inhibit Eu3+ sensitisation. Further investigations into these processes using transient absorption spectroscopy suggest that substitution at the α-C position may significantly decrease sensitisation via the antenna effect.
Electrochemical fabrication of cobalt and nickel tips for scanning tunneling microscopy
Publisher: American Vacuum Society
Date: 11-2005
DOI: 10.1116/1.2131873
Abstract: Scanning tunneling microscopy (STM) is a powerful technique to map the distribution of the density of electronics states of conductive surfaces with angstrom (Å) resolution. STM requires sharp conductive tips in order to operate in ambient conditions, which are stable with respect to oxidation. We describe a procedure to obtain high quality tips from wires of different materials such as Co and Ni. We discuss in detail the electrochemical process employed in the fabrication of the tips and assess the shape of the tips by optical microscopy and scanning electron microscopy (SEM). These tips yield high-resolution STM images even after a few weeks of exposure to air.
Lanthanoid complexes supported by retro-Claisen condensation products of β-triketonates
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8DT03585G
Abstract: Structures varying from polynuclear assemblies to coordination polymers are formed when β-triketonate ligands undergo retro-Claisen condensation reactions in the presence of lanthanoids.
New heterometallic Ir(iii )2–Eu(iii ) complexes: white light emission from a single molecule
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4DT01910E
Abstract: Pure white light emission from a single-molecule Ir 2 ( iii )–Eu( iii ) complex can be achieved with appropriate ligands.
Rhenium tetrazolato complexes coordinated to thioalkyl-functionalised phenanthroline ligands: synthesis, photophysical characterisation, and incubation in live HeLa cells
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5DT03470A
Abstract: Thioalkyl-functionalised Re(I) tetrazolato complexes highlight good accumulation and lack of photobleaching in live He-La cells.
Rhenium N-heterocyclic carbene complexes block growth of aggressive cancers by inhibiting FGFR- and SRC-mediated signalling
Publisher: Springer Science and Business Media LLC
Date: 12-2020
DOI: 10.1186/S13046-020-01777-7
Abstract: Platinum-based anticancer drugs have been at the frontline of cancer therapy for the last 40 years, and are used in more than half of all treatments for different cancer types. However, they are not universally effective, and patients often suffer severe side effects because of their lack of cellular selectivity. There is therefore a compelling need to investigate the anticancer activity of alternative metal complexes. Here we describe the potential anticancer activity of rhenium-based complexes with preclinical efficacy in different types of solid malignancies. Kinase profile assay of rhenium complexes. Toxicology studies using zebrafish. Analysis of the growth of pancreatic cancer cell line-derived xenografts generated in zebrafish and in mice upon exposure to rhenium compounds. We describe rhenium complexes which block cancer proliferation in vitro by inhibiting the signalling cascade induced by FGFR and Src. Initially, we tested the toxicity of rhenium complexes in vivo using a zebrafish model and identified one compound that displays anticancer activity with low toxicity even in the high micromolar range. Notably, the rhenium complex has anticancer activity in very aggressive cancers such as pancreatic ductal adenocarcinoma and neuroblastoma. We demonstrate the potential efficacy of this complex via a significant reduction in cancer growth in mouse xenografts. Our findings provide a basis for the development of rhenium-based chemotherapy agents with enhanced selectivity and limited side effects compared to standard platinum-based drugs.
Synthesis and Photochemical Properties of Re(I) Tricarbonyl Complexes Bound to Thione and Thiazole-2-ylidene Ligands
Publisher: American Chemical Society (ACS)
Date: 19-05-2020
DOI: 10.26434/CHEMRXIV.12324875.V1
Abstract: Three Re(I) tricarbonyl complexes, with general formulation Re(N^L)(CO) 3 X (where N^L is a bidentate ligand containing a pyridine functionalized in the position 2 with a thione or a thiazol-2-ylidene group and X is either chloro or bromo) were synthesized and their reactivity explored in terms of solvent-dependent ligand substitution, both in the ground and excited states. When dissolved in acetonitrile, the complexes bound to the thione ligand underwent ligand exchange with the solvent resulting in the formation of Re(NCMe) 2 (CO) 3 X. The exchange was found to be reversible, and the starting complex was reformed upon removal of the solvent. On the other hand, the complexes appeared inert in dichloromethane or acetone. Conversely, the complex bound to the thiazole-2-ylidene ligand did not display any ligand exchange reaction in the dark, but underwent photoactivated ligand substitution when excited to its lowest metal-to-ligand charge transfer manifold. Photolysis of this complex in acetonitrile generated multiple products, including Re(I) tricarbonyl and dicarbonyl solvato-complexes as well as free thiazole-2-ylidene ligand.
[18F]Ethenesulfonyl Fluoride as a Practical Radiofluoride Relay Reagent
Publisher: Wiley
Date: 09-05-2019
Abstract: Fluorine-18 is the most utilized radioisotope in positron emission tomography (PET), but the wide application of fluorine-18 radiopharmaceuticals is hindered by its challenging labelling conditions. As such, many potentially important radiotracers remain underutilized. Herein, we describe the use of [
An attractive family of cyclometalated Ir(III) dyes functionalized with tryptophan for potential neuroimaging applications
Publisher: Elsevier BV
Date: 02-2023
Luminescent protein staining with Re(i ) tetrazolato complexes
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8DT02052C
Abstract: Re( i ) tricarbonyl diiimine complexes for the first time exploited as luminescent staining agents for SDS-PAGE.
Synthesis, reactivity and preliminary biological activity of iron(0) complexes with cyclopentadienone and amino‐appended N‐heterocyclic carbene ligands
Publisher: Wiley
Date: 03-03-2019
DOI: 10.1002/AOC.4779
Rhenium(i ) complexation–dissociation strategy for synthesising fluorine-18 labelled pyridine bidentate radiotracers
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0RA00318B
Abstract: A novel fluorine-18 radiolabelling method employing rhenium( i ) mediation is described herein. In less than 1 minute, fluorine-18 labelled complexes and ligands were synthesised in greater than 80% and 60% radiochemical yields (RCY), respectively.
Enhanced deep-blue emission from Pt(ii) complexes bound to 2-pyridyltetrazolate and an ortho-xylene-linked bis(NHC)cyclophane
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3DT50225B
Abstract: The coordination of 2-pyridyltetrazolate and ortho-xylene-linked bis(NHC)cyclophane to Pt(II) yielded a novel complex characterised by enhanced pure deep-blue emission, whose intensity can be modulated via methylation of the tetrazole ring.
A facile methodology using quantum dot multiplex labels for tracking co-transfection
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9RA03518D
Abstract: The development of efficient non-viral transfection agents capable of delivering multiple nucleic acids is crucial for the field of genome engineering. Herein a facile methodology of polyplex labelling and tracking with quantum dots is presented.
Lanthanoid/Alkali Metal β‐Triketonate Assemblies: A Robust Platform for Efficient NIR Emitters
Publisher: Wiley
Date: 29-10-2015
Abstract: The reaction of hydrated lanthanoid chlorides with tribenzoylmethane and an alkali metal hydroxide consistently resulted in the crystallization of neutral tetranuclear assemblies with the general formula [Ln(Ae⋅HOEt)(L)4 ]2 (Ln=Eu(3+) , Er(3+) , Yb(3+) Ae=Na(+) , K(+) , Rb(+) ). Analysis of the crystal structures of these species revealed a coordination geometry that varied from a slightly distorted square antiprism to a slightly distorted triangular dodecahedron, with the specific geometrical shape being dependent on the degree of lattice solvation and identity of the alkali metal. The near-infrared (NIR)-emitting assemblies of Yb(3+) and Er(3+) showed remarkably efficient emission, characterized by significantly longer excited-state lifetimes (τobs ≈37-47 μs for Yb(3+) and τobs ≈4-6 μs for Er(3+) ) when compared with the broader family of lanthanoid β-diketonate species, even in the case of perfluorination of the ligands. The Eu(3+) assemblies show bright red emission and a luminescence performance (τobs ≈0.5 ms, ${{\\Phi}{{{\\rm L}\\hfill \\atop {\\rm Ln}\\hfill}}}$≈35-37 %, ηsens ≈68-70 %) more akin to the β-diketonate species. The results highlight that the β-triketonate ligand offers a tunable and facile system for the preparation of efficient NIR emitters without the need for more complicated perfluorination or deuteration synthetic strategies.
Large-scale synthesis of both symmetrical and unsymmetrical triacylglycerols containing docosahexaenoic acid
Publisher: Elsevier BV
Date: 09-2008
Redox Properties of a Rhenium Tetrazolato Complex in Room Temperature Ionic Liquids: Assessing the Applicability of the Stokes–Einstein Equation for a Metal Complex in Ionic Liquids
Publisher: American Chemical Society (ACS)
Date: 26-03-2012
DOI: 10.1021/JP3007975
Luminescent Metal Complexes as Emerging Tools for Lipid Imaging
Publisher: Springer Science and Business Media LLC
Date: 17-08-2022
DOI: 10.1007/S41061-022-00400-X
Abstract: Fluorescence microscopy is a key tool in the biological sciences, which finds use as a routine laboratory technique (e.g., epifluorescence microscope) or more advanced confocal, two-photon, and super-resolution applications. Through continued developments in microscopy, and other analytical methods, the importance of lipids as constituents of subcellular organelles, signalling or regulating molecules continues to emerge. The increasing recognition of the importance of lipids to fundamental cell biology (in health and disease) has prompted the development of protocols and techniques to image the distribution of lipids in cells and tissues. A erse suite of spectroscopic and microscopy tools are continuously being developed and explored to add to the “toolbox” to study lipid biology. A relatively recent breakthrough in this field has been the development and subsequent application of metal-based luminescent complexes for imaging lipids in biological systems. These metal-based compounds appear to offer advantages with respect to their tunability of the photophysical properties, in addition to capabilities centred around selectively targeting specific lipid structures or classes of lipids. The presence of the metal centre also opens the path to alternative imaging modalities that might not be applicable to traditional organic fluorophores. This review examines the current progress and developments in metal-based luminescent complexes to study lipids, in addition to exploring potential new avenues and challenges for the field to take.
Ligand-Induced Structural, Photophysical, and Electrochemical Variations in Tricarbonyl Rhenium(I) Tetrazolato Complexes
Publisher: American Chemical Society (ACS)
Date: 17-06-2013
DOI: 10.1021/OM400356N
Dendronised Polymers as Templates for In Situ Quantum Dot Synthesis
Publisher: CSIRO Publishing
Date: 2020
DOI: 10.1071/CH20071
Abstract: The utility of dendrimers as effective carriers for targeted drug delivery and imaging has been facilitated by a high degree of molecular uniformity, narrow molecular weight distribution, tunable size and shape characteristics, and multivalency. Dendrimer–quantum dot (QD) nanocomposites have traditionally been synthesised by electrostatic self-assembly of preformed dendrimers and QDs, but higher generations are associated with limited flexibility and increased cytotoxicity. In this paper, we report the fabrication of CdTe QD nanoparticles using a dendronised linear copolymer bearing thiolated fourth-generation poly(amido amine) (PAMAM) dendrons as the capping and stabilising agent. We demonstrate this approach enables synthesis of nanocomposites with aqueous and photophysical stability.
Charge Injection Across Self-Assembly Monolayers in Organic Field-Effect Transistors: Odd−Even Effects
Publisher: American Chemical Society (ACS)
Date: 05-2007
DOI: 10.1021/JA069235M
Abstract: We investigate the role of self-assembly monolayers in modulating the response of organic field-effect transistors. Alkanethiol monolayers of chain length n are self-assembled on the source and drain electrodes of pentacene field-effect transistors. The charge carrier mobility mu exhibits large fluctuations correlated with odd-even n. For n or = 8, mu decays exponentially with an inverse decay length beta = 0.6 A(-1). Our results show that (i) charge injection across the interface occurs by through-bond tunneling of holes mediated by the alkanethiol layer (ii) in the long-chain regime, the charge injection across the alkanethiol monolayer completely governs the transistor response (iii) the transistor is a sensitive gauge for probing charge transport across single monolayers. The odd-even effect is ascribed to the anisotropic coupling between the alkanethiol terminal sigma bond and the HOMO level of ordered pentacene molecules.
Bottom–up nanofabrication of materials for organic electronics
Publisher: Elsevier BV
Date: 11-2004
Correction: Naphthalene flanked diketopyrrolopyrrole based organic semiconductors for high performance organic field effect transistors
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8NJ90083C
Abstract: Correction for ‘Naphthalene flanked diketopyrrolopyrrole based organic semiconductors for high performance organic field effect transistors’ by Qian Liu et al. , New J. Chem. , 2018, 42 , 12374–12385.
A platinum(II)-napthalimide probe for sub-cellular imaging of bacteria
Publisher: American Chemical Society (ACS)
Date: 24-02-2020
DOI: 10.26434/CHEMRXIV.8299274
Abstract: There is a lack of molecular probes for imaging bacteria, in comparison to the array of such tools available for the imaging of mammalian cells. A platinum(II)-naphthalimide molecule has been developed as a small molecule probe for bacterial imaging, designed to have the potential for correlative imaging. The naphthalimide moiety acts as a luminescent probe for super-resolution microscopy, functioning independently of the platinum(II) centre which enabled visualisation of the complex with ion nanoscopy. Structured illumination microscopy (SIM) imaging on live i Bacillus cereus /i confirmed the suitability of the probe for super-resolution microscopy. NanoSIMS analysis was used to monitor the uptake of the platinum(II) complex within the bacteria and proved the multimodal action of the probe. The successful combination of these two probe moieties introduces a platform that could lead to a versatile range of correlative probes for bacteria. br
Luminescent lanthanoid complexes of a tetrazole-functionalised calix[4]arene
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2DT12246D
Abstract: p-t-Butylcalix[4]arene functionalised at the lower rim with two tetrazole moieties is found to be a useful receptor for lanthanoid cations. The luminescence of the resulting complexes can be controlled by addition of base, with emission achieved in the visible and infrared regions.
Modulation of the organelle specificity in Re(i ) tetrazolato complexes leads to labeling of lipid droplets
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4RA00050A
Abstract: Neutral Re( i ) tetrazolato complexes exhibit labeling of lipid droplets with high specificity.
N-Heterocyclic carbenes as π*-acceptors in luminescent Re(i) triscarbonyl complexes
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C1DT11233C
Abstract: Two rhenium(I) carbonyl complexes of the type fac-[Re(CO)(3)(N^C)X] where N^C is an N-heterocyclic carbene [3-butyl-1-(2'-pyridyl)benzimidazolin-2-ylidene] and X is either Cl or Br have been synthesised via an in situ method from [Re(CO)(5)X] and a respective benzimidazolium salt. The complexes have been characterised by (1)H and (13)C NMR, infra-red spectroscopy and in the case of the bromo-complex by a single-crystal X-ray diffraction study. The photophysical properties of the complexes have been investigated, revealing similar phosphorescent emission which was attributed to radiative decay from a (3)MLCT state partially mixed with a (3)LLCT state. However, the analysis of excited state lifetime and quantum yield values revealed distinct photophysical behaviour for the two complexes, which was attributed to the more labile nature of the bromo ligand with respect to the chloro one. The explanation was supported by the time-dependent emission profile change in diluted acetonitrile solutions.
Facile Methods for the Separation of the cis- and trans-Diastereomers of Limonene 1,2-Oxide and Convenient Routes to Diequatorial and Diaxial 1,2-Diols
Publisher: Georg Thieme Verlag KG
Date: 12-02-0005
Synthesis, Solid-state Structures, Solution Behaviour and Catalysis Studies of Nickel Complexes of Bis(benzimidazolin-2-ylidene)pyridine Pincer Ligands
Publisher: CSIRO Publishing
Date: 2012
DOI: 10.1071/CH12044
Abstract: N-Heterocyclic carbene–nickel complexes with five- and four-coordinate geometries [(CNC)NiBr2] and [(CNC)NiBr]X (X = PF6 or BPh4) have been prepared with the pincer ligands 2,6-bis(N-octylbenzimidazolin-2-ylidene)pyridine and 2,6-bis(N-butyl-5,6-dimethoxybenzimidazolin-2-ylidene)pyridine. The addition of the n-octyl substituent significantly extends the solubility of the complexes and has allowed UV-vis solution studies of the complexes in dichloromethane and methanol. The four- and five-coordinate species exist in equilibrium in solution and this equilibrium has been explored by UV-vis studies. The complexes have also been characterized by NMR studies, and single crystal X-ray diffraction studies have been performed on [(CNC)NiBr2] (where CNC = 2,6-bis(N-octylbenzimidazolin-2-ylidene)pyridine) and [(CNC)NiBr]BPh4 (where CNC = 2,6-bis(N-butyl-5,6-dimethoxybenzimidazolin-2-ylidene)pyridine).
Analyzing the Relation between Structure and Aggregation Induced Emission (AIE) Properties of Iridium(III) Complexes through Modification of Non‐Chromophoric Ancillary Ligands
Publisher: Wiley
Date: 13-11-2018
Investigating vaterite phase stabilisation by a tetrazole molecule during calcium carbonate crystallisation
Publisher: Elsevier BV
Date: 07-2012
Unprecedented staining of polar lipids by a luminescent rhenium complex revealed by FTIR microspectroscopy in adipocytes
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6MB00242K
Abstract: Localisation of a neutral rhenium( i ) tricarbonyl phenanthroline species to regions of high polar lipid concentrations is demonstrated by Fourier transform infrared (FTIR) microspectroscopy.
Labeled Rhenium Complexes: Radiofluorination, α-MSH Cyclization, and Deuterium Substitutions
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Mitochondria-targeting transition metal complexes
Publisher: Elsevier
Date: 2022
Tetrazole functional copolymers: Facile access to well-defined Rhenium(I)-Polymeric luminescent materials
Publisher: Elsevier BV
Date: 06-2020
Alkyl tetrazoles as diimine (“diim”) ligands for fac-[Re(diim)(CO)3(L)]-type complexes. Synthesis, characterization and preliminary studies of the interaction with bovine serum albumin
Publisher: Elsevier BV
Date: 04-2021
Intracellular distribution and stability of a luminescent rhenium(i ) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with X-ray fluorescence imaging
Publisher: Oxford University Press (OUP)
Date: 2017
DOI: 10.1039/C6MT00243A
Abstract: Optical epifluorescence microscopy was used in conjunction with X-ray fluorescence imaging to monitor the stability and intracellular distribution of the luminescent rhenium(i) complex fac-[Re(CO)
The photochemistry of rhenium(i) tricarbonyl N-heterocyclic carbene complexes
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3DT51614H
Abstract: The photophysical and photochemical properties of the new tricarbonyl rhenium(I) complexes bound to N-heterocyclic carbene ligands (NHC), fac-[Re(CO)3(N^C)X] (N^C = 1-phenyl-3-(2-pyridyl)imidazole or 1-quinolinyl-3-(2-pyridyl)imidazole X = Cl or Br), are reported. The photophysics of these complexes highlight phosphorescent emission from triplet metal-to-ligand ((3)MLCT) excited states, typical of tricarbonyl rhenium(I) complexes, with the pyridyl-bound species displaying a ten-fold shorter excited state lifetime. On the other hand, these pyridyl-bound species display solvent-dependent photochemical CO dissociation following what appear to be two different mechanisms, with a key step being the formation of cationic tricarbonyl solvato-complexes, being themselves photochemically active. The photochemical mechanisms are illustrated with a combination of NMR, IR, UV-Vis, emission and X-ray structural characterization techniques, clearly demonstrating that the presence of the NHC ligand is responsible for the previously unobserved photochemical behavior in other photoactive tricarbonyl rhenium(I) species. The complexes bound to the quinolinyl-NHC ligand (which possess a lower-energy (3)MLCT) are photostable, suggesting that the photoreactive excited state is not any longer thermally accessible. The photochemistry of the pyridyl complexes was investigated in acetonitrile solutions and also in the presence of triethylphosphite, showing a competing and bifurcated photoreactivity promoted by the trans effect of both the NHC and phosphite ligands.
Structure illumination microscopy imaging of lipid vesicles in live bacteria with naphthalimide-appended organometallic complexes
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1AN00363A
Abstract: Staining bacteria is made more informative with a probe that enables imaging using super-resolution microscopy, and ion nanoscopy.
Negatively charged Ir(iii ) cyclometalated complexes containing a chelating bis-tetrazolato ligand: synthesis, photophysics and the study of reactivity with electrophiles
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6DT02524B
Abstract: The synthesis, the reactivity toward electrophiles and use for Ir( iii ) based soft salts of new anionic Ir( iii ) complexes containing a bis-tetrazolato ligand are described herein.
Synthesis and Photochemical Properties of Re(I) Tricarbonyl Complexes Bound to Thione and Thiazol-2-ylidene Ligands
Publisher: American Chemical Society (ACS)
Date: 24-08-2020
Properties and prospects for rhenium(i ) tricarbonyl N-heterocyclic carbene complexes
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8CC06596A
Abstract: Rhenium tricarbonyl complexes bound to N-heterocyclic carbene ligands are emerging as a new class of complexes with promising applications in a wide variety of areas.
A “plug-and-play” approach to the preparation of transparent luminescent hybrid materials based on poly(methyl methacrylate), a calix[4]arene cross-linking agent, and terbium ions
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C0CC05570K
Abstract: A novel methodology to prepare transparent luminescent hybrid materials is reported. Using a calixarene ionophore as a PMMA cross-linker avoids problems, such as phase segregation, and produces a polymer monolith that can be loaded with the metal ion required for luminescence post-synthesis. This approach is versatile and will simplify the production of such materials.
Visible and Near-Infrared Emission from Lanthanoid β-Triketonate Assemblies Incorporating Cesium Cations
Publisher: American Chemical Society (ACS)
Date: 11-07-2017
DOI: 10.1021/ACS.INORGCHEM.7B00928
Abstract: The reaction of the β-triketonate ligands tris(4-methylbenzoyl)methanide and tribenzoylmethanide with the trivalent lanthanoids Eu
Tetrazoles: a new class of compound for crystallization modification
Publisher: Royal Society of Chemistry (RSC)
Date: 2010
DOI: 10.1039/C0CE00263A
A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions
Publisher: Wiley
Date: 11-04-2017
Abstract: Azeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents. However, this time-consuming process also limits fluorine-18 incorporation, due to radioactive decay of the isotope and its adsorption to the drying vessel. In addressing these limitations, the fluorine-18 radiolabeling of one model rhenium(I) complex is reported here, which is significantly improved under conditions that do not require azeotropic drying. This work could open a route towards the investigation of a simplified metal-mediated late-stage radiofluorination method, which would expand upon the accessibility of new PET and PET-optical probes.
Analyzing the Relation between Structure and Aggregation Induced Emission (AIE) Properties of Iridium(III) Complexes through Modification of Non‐Chromophoric Ancillary Ligands
Publisher: Wiley
Date: 27-12-2018
Electrochemical preparation of cobalt tips for scanning tunneling microscopy
Publisher: AIP Publishing
Date: 21-11-2002
DOI: 10.1063/1.1518127
Abstract: Here we describe a straightforward electrochemical method for fabricating sharp cobalt tips. Such tips are particularly useful for those scanning tunneling microscopy (STM) experiments where the focus is on magnetic properties of the surface and the spin polarized (SP) tunneling current is the relevant property, such as in SPSTM and SP scanning tunneling spectroscopy.
Photophysical Investigation of near Infrared Emitting Lanthanoid Complexes Incorporating Tris(2-Naphthoyl)methane as a New Antenna Ligand
Publisher: American Chemical Society (ACS)
Date: 22-01-2019
DOI: 10.26434/CHEMRXIV.7611188.V1
Abstract: A conjugated β -triketone, tris(2-naphthoyl)methane ( tnm H), has been synthesized and successfully utilized as an antenna moiety for sensitization of the trivalent lanthanoids Eu 3+ , Sm 3+ , Yb 3+ and Nd 3+ , in an isomorphous series of mononuclear complexes formulated as [Ln( tnm ) 3 (DMSO) 2 ] (Ln 3+ = Nd 3+ , Sm 3+ , Eu 3+ , Gd 3+ and Yb 3+ ). The photophysical properties of the materials were characterized as comprehensively as possible, with overall quantum yields, intrinsic quantum yields based on calculated radiative decays, and sensitization efficiencies reported. This investigation improves understanding of the sensitization processes occurring in the near-infrared (NIR) region systems in particular, where quantitative data is currently scarce. In fact, the [Yb( tnm ) 3 (DMSO) 2 ] and its deuterated analogue, [Yb( tnm ) 3 ( d 6 - DMSO) 2 ], present high values of overall quantum yield of 4% and 6%, respectively, which makes them useful and readily accessible references for future investigation of NIR-emitting systems.
Effects of Surface Chemical Composition on the Early Growth Stages of α-Sexithienyl Films on Silicon Oxide Substrates
Publisher: American Chemical Society (ACS)
Date: 07-12-2005
DOI: 10.1021/JP053814G
Abstract: In organic field effect transistors, charge transport is confined to a narrow region next to the organic/dielectric interface. It is thus extremely important to determine the morphology and the molecular arrangement of the organic films at their early growth stages. On a substrate of technological interest, such as thermally grown silicon oxide, it has been recently found that alpha-sexithienyl aggregates made of flat-lying molecules can simultaneously nucleate besides islands made of molecules standing vertical. In this paper, we investigate the effects due to variations in surface chemical composition on alpha-sexithienyl ultrathin film formation. Flat-lying molecules are no longer detected when Si-OH groups present at the surface are chemically removed but also when the Si-OH or Si-H group density is maximized. This gives evidence that variations in the surface chemical composition can largely affect the nucleation and growth processes of organic/dielectric interfaces. We hypothesize that isolated OH groups can interact with alpha-sexithienyl molecules and anchor them down flat with respect to the surface.
Ionophoric properties of a tetra-tetrazole functionalised calix[4]arene
Publisher: Informa UK Limited
Date: 23-10-2015
Lanthanoid pyridyl-β-diketonate ‘triangles’. New examples of single molecule toroics
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0DT02855J
Abstract: Trinuclear lanthanoid clusters have been synthesised and investigated as toroidal spin systems.
Structure, derivatisation, and metal complexation of p-cyclohexylcalix[4]arene
Publisher: Informa UK Limited
Date: 03-06-2021
Synthesis, Photophysical and Electrochemical Investigation of Dinuclear Tetrazolato-Bridged Rhenium Complexes
Publisher: American Chemical Society (ACS)
Date: 29-10-2012
DOI: 10.1021/OM300870A
Antibacterial activity of a new class of tris homoleptic Ru (II)‐complexes with alkyl‐tetrazoles as diimine‐type ligands
Publisher: Wiley
Date: 28-05-2020
DOI: 10.1002/AOC.5806
Lanthanoid “Bottlebrush” Clusters: Remarkably Elongated Metal–Oxo Core Structures with Controllable Lengths
Publisher: American Chemical Society (ACS)
Date: 14-10-2014
DOI: 10.1021/JA506677H
Abstract: Large metal-oxo clusters consistently assume spherical or regular polyhedral morphologies rather than high-aspect-ratio structures. Access to elongated core structures has now been achieved by the reaction of lanthanoid salts with a tetrazole-functionalized calixarene in the presence of a simple carboxylate co-ligand. The resulting Ln19 and Ln12 clusters are constructed from apex-fused Ln5O6 trigonal bipyramids and are formed consistently under a range of reaction conditions and reagent ratios. Altering the carboxylate co-ligand structure reliably controls the cluster length, giving access to a new class of rod-like clusters of variable length.
Energy transfer between Eu3+ and Nd3+ in near-infrared emitting β-triketonate coordination polymers
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8DT02499E
Abstract: Mixed coordination polymers containing Eu 3+ and Nd 3+ cations display energy forward and back migration between Eu 3+ and Nd 3+ , resulting in dual red and near-infrared emission.
Frontispiece: Fluorine‐18 Radiolabelling and Photophysical Characteristics of Multimodal PET–Fluorescence Molecular Probes
Publisher: Wiley
Date: 13-01-2021
Proton-Induced Reversible Modulation of the Luminescent Output of Rhenium(I), Iridium(III), and Ruthenium(II) Tetrazolate Complexes
Publisher: American Chemical Society (ACS)
Date: 20-12-2013
DOI: 10.1021/IC402187E
Abstract: One of the distinct features of metal-tetrazolate complexes is the possibility of performing electrophilic additions onto the imine-type nitrogens of the coordinated five-membered ring. These reactions, in particular, provide a useful tool for varying the main structural and electronic properties of the starting tetrazolate complexes. In this paper, we demonstrate how the use of a simple protonation-deprotonation protocol enables us to reversibly change, to a significant extent, the light-emission output and performance of a series of Re(I)-tetrazolate-based phosphors of the general formulation fac-[Re(N(∧)N)(CO)3L], where N(∧)N denotes diimine-type ligands such as 2,2'-bipyridine (bpy) or 1,10-phenanthroline (phen) and L represents a series of different 5-aryl tetrazolates. Indeed, upon addition of triflic acid to these neutral Re(I) complexes, a consistent blue shift (Δλmax ca. 50 nm) of the emission maximum is observed and the protonated species also display increased quantum yield values (4-13 times greater than the starting compounds) and longer decay lifetimes. This alteration can be reversed to the initial condition by further treating the protonated Re(I) complex with a base such as triethylamine. Interestingly, the reversible modulation of luminescent features by the same protonation-deprotonation mechanism appears as a quite general characteristic of photoactive metal tetrazolate complexes, even for compounds in which the 2-pyridyl tetrazolate ligands coordinate the metal center with a bidentate mode, such as the corresponding Ir(III) cyclometalates [Ir(C(∧)N)2L] and the Ru(II) polypyridyl derivatives [Ru(bpy)2L](+). In these cases, the protonation of the starting materials leads to red-shifted and more intense emissions for the Ir(III) complexes, while almost complete quenching is observed in the case of the Ru(II) analogues.
Metal complexes as a promising source for new antibiotics
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9SC06460E
Abstract: There is a dire need for new compounds to combat antibiotic resistance: metal complexes might provide the solution. 906 metal complexes were evaluated against dangerous ESKAPE pathogens and found to have a higher hit-rate than organic molecules.
Influence of the para‐Substituent in Lanthanoid Complexes of Bis‐Tetrazole‐Substituted Calix[4]arenes
Publisher: Wiley
Date: 07-11-2019
Abstract: 5,11,17,23‐Tetra‐ tert ‐butyl‐25,27‐dihydroxy‐26,28‐bis(tetrazole‐5‐ylmethoxy)calix[4]arene has been reported to form remarkable Ln19 and Ln12 elongated clusters, upon addition of aqueous ammonium carboxylates. The impact of the para substituent on lanthanoid cluster formation has been studied by synthesising two new bis‐tetrazole calixarenes, with p ‐H, and p ‐allyl substituents. Solution phase dynamic light scattering measurements of the reaction mixtures indicated that clusters are not formed with the p ‐H and p ‐allyl derivatives, in contrast with the behaviour of the tert ‐butyl analogue. Lanthanoid complexes of the p ‐H and p ‐allyl calixarenes were characterised by single‐crystal X‐ray diffraction, and were found to form mononuclear complexes, linked to form a one‐dimensional coordination polymer for the p ‐allyl system. All of the complexes were isolated as ammonium salts, with ammonium cation included in the calixarene cavity in most cases. It is concluded that the nature of the para substituent has a profound impact on the lanthanoid cluster formation process, and derivatives with more subtle structural changes will be required to determine if additional lanthanoid “bottlebrush” clusters can be isolated.
Spontaneous Fabrication of Microscopic Arrays of Molecular Structures with Submicron Length Scales
Publisher: American Chemical Society (ACS)
Date: 21-05-2002
DOI: 10.1021/NL0255496
Luminescent metal complexes as emerging tools for lipid imaging
Publisher: Springer International Publishing
Date: 2022
DOI: 10.1007/978-3-031-19863-2_3
Abstract: Fluorescence microscopy is a key tool in the biological sciences, which finds use as a routine laboratory technique (e.g., epifluorescence microscope) or more advanced confocal, two-photon, and super-resolution applications. Through continued developments in microscopy, and other analytical methods, the importance of lipids as constituents of subcellular organelles, signalling or regulating molecules continues to emerge. The increasing recognition of the importance of lipids to fundamental cell biology (in health and disease) has prompted the development of protocols and techniques to image the distribution of lipids in cells and tissues. A erse suite of spectroscopic and microscopy tools are continuously being developed and explored to add to the “toolbox” to study lipid biology. A relatively recent breakthrough in this field has been the development and subsequent application of metal-based luminescent complexes for imaging lipids in biological systems. These metal-based compounds appear to offer advantages with respect to their tunability of the photophysical properties, in addition to capabilities centred around selectively targeting specific lipid structures or classes of lipids. The presence of the metal centre also opens the path to alternative imaging modalities that might not be applicable to traditional organic fluorophores. This review examines the current progress and developments in metal-based luminescent complexes to study lipids, in addition to exploring potential new avenues and challenges for the field to take.
Elucidation of LMCT Excited States for Lanthanoid Complexes: A Theoretical and Solid-State Experimental Framework
Publisher: American Chemical Society (ACS)
Date: 23-08-2022
DOI: 10.1021/ACS.INORGCHEM.2C01985
Abstract: Photophysical and magnetic properties arising from both ground and excited states of lanthanoid ions are relevant for numerous applications. These properties can be substantially affected, both adversely and beneficially, by ligand-to-metal charge-transfer (LMCT) states. However, probing LMCT states remains a significant challenge in f-block chemistry, particularly in the solid state. Intriguingly, the europium compounds [Eu
Synthesis, Structural, and Photophysical Investigation of Diimine Triscarbonyl Re(I) Tetrazolato Complexes.
Publisher: American Chemical Society (ACS)
Date: 26-01-2011
DOI: 10.1021/IC1015516
Abstract: The synthesis, structural, and photophysical properties of a novel family of neutral fac-[Re(N(∧)N)(CO)(3)(L)] complexes, where N(∧)N is either 2,2'-bipyridine or 1,10-phenanthroline and L is a para functionalized 5-aryltetrazolate [namely, 5-phenyltetrazolate (Tph(-)), 4-(tetrazolate-5-yl)benzaldehyde (Tbdz(-)), 5-(4-acetylphenyl)tetrazolate (Tacy(-)), and methyl 4-(tetrazolate-5-yl)benzoate (Tmeb(-))] are reported. The complexes were prepared by direct addition of the corresponding tetrazolate anion to the acetonitrile solvated fac-[Re(N(∧)N)(CO)(3)](+) precursor. NMR data demonstrate that the coordination of the metal fragment is regiospecific at the N2 atom of the tetrazolate ring. These conclusions are also supported by X-ray structural determinations. Photophysical data were obtained in diluted and deaerated dichloromethane solutions displaying broad and structureless profiles with emission maxima ranging from 566 to 578 nm. The absorption profiles indicate the presence of higher energy intraligand (IL) π-π* transitions and lower energies ligand-to-ligand charge transfer (LLCT) and metal-to-ligand charge transfer (MLCT). As the last two transitions are mixed, they are better described as a metal-ligand-to-ligand charge transfer (MLLCT), a result that is also supported by density functional theory (DFT) calculations. The complexes show excited state lifetime values ranging from 102 to 955 ns, with associated quantum yield between 0.012 and 0.099. Compared to the parent neutral chloro or bromo [Re(N(∧)N)(CO)(3)X], the complexes show a slightly improved performance because of the π accepting nature of the tetrazolato ligand. The metal-to-ligand backbonding is in fact depleting the Re center of electron density, thus widening the HOMO-LUMO gap and reducing the non-radiative decay mechanism in accordance with the energy gap law. Finally, the electron-withdrawing or donating nature of the substituent on the phenyltetrazolato ligand allows the fine-tuning of the photophysical properties.
A Molecular Probe for the Detection of Polar Lipids in Live Cells
Publisher: Public Library of Science (PLoS)
Date: 23-08-2016
Spectroscopic and molecular docking study of the interaction between neutral Re(I) tetrazolate complexes and bovine serum albumin.
Publisher: Wiley
Date: 17-06-2021
Abstract: Re(I) complexes have potential in biomedical sciences as imaging agents, diagnostics and therapeutics. Thus, it is crucial to understand how Re(I) complexes interact with carrier proteins, like serum albumins. Here, two neutral Re(I) complexes were used ( fac ‐[Re(CO) 3 (1,10‐phenanthroline)L], in which L is either 4‐cyanophenyltetrazolate (1) or 4‐methoxycarbonylphenyltetrazole ester (2) , to study the interactions with bovine serum albumin (BSA). Spectroscopic measurements, calculations of thermodynamic and Förster resonance energy transfer parameters, as well as molecular modelling, were performed to study differential binding between BSA and complex 1 and 2 . Induced‐fit docking combined with quantum‐polarised ligand docking were employed in what is believed to be a first for a Re(I) complex as a ligand for BSA. Our findings provide a basis for other molecular interaction studies and suggest that subtle functional group alterations at the terminal region of the Re(I) complex have a significant impact on the ability of this class of compounds to interact with BSA.
Lipid profiles of prostate cancer cells
Publisher: Impact Journals, LLC
Date: 30-10-2018
Formation of HoIII Trinuclear Clusters and GdIII Monodimensional Polymers Induced by ortho and para Regioisomers of Pyridyl‐Functionalised β‐Diketones: Synthesis, S
Publisher: Wiley
Date: 02-2009
Multifunctional hybrid materials based on transparent poly(methyl methacrylate) reinforced by lanthanoid hydroxo clusters
Publisher: Royal Society of Chemistry (RSC)
Date: 2010
DOI: 10.1039/C0DT00947D
Abstract: Three pentanuclear lanthanoid hydroxo clusters of composition [Ln(OH)(5)(abzm)(10)], where Ln = Eu, Tb, Ho and abzm = di(4-allyloxy)benzoylmethanide, have been prepared. The structures have been characterised by means of IR, Raman, elemental analyses and X-ray diffraction, showing a pyramidal square-based cluster core. The clusters (Tb and Ho) exhibit Curie-Weiss Law behaviour, displaying antiferromagnetic ordering at low temperatures. The emission properties of the Eu cluster demonstrate the abzm(-) ligand is an efficient antenna (λ(ex) = 420 nm) only for the sensitisation of Eu luminescence in the visible range, via energy transfer to the (5)D(0) state of the trivalent metal. The clusters have been reacted in the presence of methyl methacrylate and azobisisobutyronitrile to prepare reinforced polymers via radical polymerisation. The obtained materials exhibit swelling upon immersion into organic solvents up to ≈ 110% of their original size, in agreement with the presence of cluster-crosslinked polymeric chains. Also, no loss of transparency was observed in the preparation of the materials. The characteristic red emission of the Eu cluster in also retained in the polymeric material.
Blue emitting C-2-symmetrical dibenzothiazolyl substituted pyrrole, furan and thiophene
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3TC00760J
Energy Transfer Between Eu3+ and Nd3+ in Near-Infrared Emitting β-Triketonate Coordination Polymers
Publisher: American Chemical Society (ACS)
Date: 17-07-2018
DOI: 10.26434/CHEMRXIV.6008294.V3
Abstract: Isomorphous β -triketonate-based lanthanoid polymers containing tris(4-methylbenzoyl)methanide ( mtbm ) and Rb + with formula,{[Ln(Rb)( mtbm ) 4 ] 2 } n (Ln = Eu 3+ and Nd 3+ ) have been synthesised and structurally characterised. The photophysical properties for the Nd 3+ complex presented long lifetimes and relatively high quantum yields in comparison with analogous β -diketonate complexes. Mixed lanthanoid complexes were also formed and their luminescence properties studied, with effective sensitisation of the 4 F 3/2 of Nd 3+ via the 5 D 0 of Eu 3+ , which is to the best of our knowledge the first ex le of Eu 3+ to Nd 3+ sensitisation in a coordination complex or polymer.
Photochemical Processes in a Rhenium(I) Tricarbonyl N-Heterocyclic Carbene Complex Studied by Time-Resolved Measurements
Publisher: American Chemical Society (ACS)
Date: 27-02-2017
DOI: 10.1021/ACS.INORGCHEM.6B02936
Abstract: We carried out time-resolved infrared (TR-IR) and emission lifetime measurements on a Re(I) carbonyl complex having an N-heterocyclic carbene ligand, namely, fac-[Re(CO)
Recyclable calix[4]arene–lanthanoid luminescent hybrid materials with color-tuning and color-switching properties
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3DT33059A
Abstract: Inorganic-organic hybrid materials combine the properties of both components providing functionality with a wide range of potential applications. Phase segregation of the inorganic and organic components is a common challenge in these systems, which is overcome here by copolymerizing a metal-free calixarene ionophore and methyl methacrylate. A lanthanoid ion is then added using a swelling-deswelling procedure. The resulting luminescent hybrid materials can be made to emit any required color, including white light, by loading with an appropriate mixture of lanthanoids. The gradation of the emitted color can also be finely adjusted by changing the excitation wavelength. The polymer monolith can be recycled to emit a different color by swelling with a solution containing a different lanthanoid ion. This methodology is flexible and has the potential to be extended to many different ionophores and polymer matrices.
Gelation of La(iii) cations promoted by 5-(2-pyridyl)tetrazolate and water
Publisher: Royal Society of Chemistry (RSC)
Date: 2006
DOI: 10.1039/B605006A
Abstract: Addition of water to the product formed when LaCl3 and 1H-5-(2-pyridyl)tetrazole (LH) were treated with an excess of triethylamine in ethanol, resulted in the reversible formation of a hydrogel, which when further treated with EtOH-iPrOH produced crystals of [LaL3(H2O)3].(H2O)4, as determined by X-ray crystallography.
Influence of the substrate hydrophilicity on the grid assisted deposition of tris-(8-hydroxyquinolinato) aluminum(III) thin films
Publisher: Elsevier BV
Date: 02-2009
Synthesis and characterization of homo- and heterovalent tetra- hexa- hepta- and decanuclear manganese clusters using pyridyl functionalized β-diketone, carboxylate and triethanolamine ligands
Publisher: Royal Society of Chemistry (RSC)
Date: 2010
DOI: 10.1039/C0DT00054J
Abstract: The syntheses and characterizations are reported for six new homo- and heterovalent manganese clusters, utilizing pyridyl functionalized beta-diketones ligands. The reaction of the trinuclear complex [Mn3O(O2CPh)6(H2O)(Py)2] with 1,3-di(pyridine-2-yl)propane-1,3-dione (dppdH) in CH2Cl2 resulted in a mixed-valence Mn3(II)Mn6(III)Mn(IV) decanuclear cluster of formula [Mn10O7(dppd)3(O2CPh)11] x 4 CH2Cl2 (1). The structure of the core of 1 is based upon a centred tricapped trigonal prism. Reacting Mn(BF4)2 x xH2O with dppdH and triethylamine (NEt3) in CH2Cl2-MeOH gave a rare, homoleptic hexanuclear cluster of formula [Mn(II)6(dppd)8][BF4]4 (2) which has a triangular based core. Reaction of Mn(Y)2 x xH2O, Y = NO3(-) or BF4(-), with dppdH or 1-phenyl-3-(2-pyridyl)propane-1,3-dione (pppdH) in the presence of triethanolamine (teaH3) and NEt3 gave a heptanuclear 'disc' like manganese core of general formula [Mn(II)7(X)6(tea)(OH)3][Y]2 x solv (3) X = pppd- or dppd- and Y = NO3(-) or BF4(-). The addition of N-(2-pyridinyl)acetoacetamide (paaH) to Mn(Y)2 x 4 H2O Y = NO3(-) or ClO4(-) in MeOH gave a second alent heptanuclear cluster with a 'disc'-like core of general formula [Mn7(paa)6(OMe)6][X]2 x solv (4) (X = NO3(-) or ClO4(-)), whilst the addition of paaH to a mixture of Mn(NO3)2 x 4 H2O, teaH3 and NEt3 in CH2Cl2-MeOH resulted in the formation of a mixed-valence Mn2(II)Mn2(III) tetranuclear 'butterfly' complex of formula [Mn4(paa)4(teaH)2][NO3]2 x 2 MeOH x 2 CH2Cl2 (5). Compound 5 displays the rare Mn(II/III) oxidation state distribution of the body positions being Mn(II) while the wing tips are Mn(III). The in situ formation of the tetranuclear [Mn4(teaH)2(teaH2)2(O2C(CH3)3)2][O2C(CH3)3]2 'butterfly' complex followed by the addition of Mn(O2CMe)2 x 4 H2O resulted in a mixed-valence Mn4(II)Mn(III)Mn(IV) hexanuclear species of formula [Mn6O2(teaH2)4(O2CMe)4][NO3]2[O2CMe] x CH2Cl2 x MeOH x 2 H2O (6). The core of 6 displays a face sharing dicubane topology. Compounds 1 and 6 both display novel trapped-valence metal cores containing three different oxidation states on the manganese ion. Compounds 1, 2 and 3 are the first manganese based dppd clusters, while 4 and 5 are the first with the pyridylamino-substituted beta-diketone ligand (paaH). The magnetic data for 1, 2, 3, 4, and 6 are dominated by antiferromagnetic interactions within the clusters, leading to small ground spin values of S = 1 for 1, S = 3 for 2, S = 5/2 for 3, S = 5/2 for 4 and S = 1/2 for 6. Compound 5, however, displays overall ferromagnetic interactions with the data indicating an S = 6 ground state. 5 also exhibits probable single molecule magnet behaviour as indicated by frequency dependent out-of-phase chiM'' peaks in the AC susceptibility measurements.
Fluorine-18 Radiolabelling and Photophysical Characteristics of Multimodal PET–Fluorescence Molecular Probes
Publisher: Wiley
Date: 09-11-2021
In utero substrate restriction by placental insufficiency or maternal undernutrition decreases optical redox ratio in foetal perirenal fat
Publisher: Wiley
Date: 10-01-2021
Fabrication of material patterns by grid-assisted deposition
Publisher: Elsevier BV
Date: 12-2003
Cyclometalated iridium(III) complexes for life science
Publisher: Elsevier BV
Date: 05-2018
Reinterpreting the Fate of Iridium(III) Photocatalysts─Screening a Combinatorial Library to Explore Light-Driven Side-Reactions
Publisher: American Chemical Society (ACS)
Date: 15-06-2022
DOI: 10.1021/JACS.2C02011
Abstract: Photoredox catalysts are primarily selected based on ground and excited state properties, but their activity is also intrinsically tied to the nature of their reduced (or oxidized) intermediates. Catalyst reactivity often necessitates an inherent instability, thus these intermediates represent a mechanistic turning point that affords either product formation or side-reactions. In this work, we explore the scope of a previously demonstrated side-reaction that partially saturates one pyridine ring of the ancillary ligand in heteroleptic iridium(III) complexes. Using high-throughput synthesis and screening under photochemical conditions, we identified different chemical pathways, ultimately governed by ligand composition. The ancillary ligand was the key factor that determined photochemical stability. Following photoinitiated electron transfer from a sacrificial tertiary amine, the reduced intermediate of complexes containing 1,10-phenanthroline derivatives exhibited long-term stability. In contrast, complexes containing 2,2'-bipyridines were highly susceptible to hydrogen atom transfer and ancillary ligand modification. Detailed characterization of selected complexes before and after transformation showed differing effects on the ground and excited state reduction potentials dependent on the nature of the cyclometalating ligands and excited states. The implications of catalyst stability and reactivity in chemical synthesis was demonstrated in a model photoredox reaction.
Synthesis and Photochemical Properties of Manganese(I) Tricarbonyl Diimine Complexes Bound to Tetrazolato Ligands
Publisher: Wiley
Date: 15-01-2020
Synthesis, bioconjugation and stability studies of [18F]ethenesulfonyl fluoride
Publisher: Wiley
Date: 12-07-2018
DOI: 10.1002/JLCR.3667
Abstract: Fluorine-18 labelled prosthetic groups (PGs) are often necessary for radiolabelling sensitive biological molecules such as peptides and proteins. Several shortcomings, however, often diminish the final yield of radiotracer. In an attempt to provide higher yielding and operationally efficient tools for radiolabelling biological molecules, we describe herein the first radiochemical synthesis of [
One-step assembly of Re(i) tricarbonyl 2-pyridyltetrazolato metallacalix[3]arene with aqua emission and reversible three-electron oxidation
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3DT50988E
Abstract: The reaction of 2-pyridyltetrazolate with [Re(CO)5X] (X = Cl, Br) yielded the formation of an unexpected cyclic metallacalix[3]arene, as revealed by X-ray structural studies, characterised by aqua emission and reversible three-electron oxidation.
Tetrazoles: calcium oxalate crystal growth modifiers
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4CE01717J
Abstract: Metabolically stable tetrazole molecules are shown to impact calcium oxalate crystallization, thus tetrazoles can be used in investigating biological crystallization processes.
Structural Variations in the Complete Series of Lanthanoid Complexes of a Calix[4]arene Trisamide
Publisher: CSIRO Publishing
Date: 2020
DOI: 10.1071/CH17484
Abstract: Lanthanoid picrate (pic) complexes of 5,11,17,23-tetra-tert-butyl-25-hydroxy-26,27,28-tris(diethylcarbamoylmethoxy)calix[4]arene (LH) have been synthesised and structurally characterised, to complete this series for all lanthanoids (other than promethium). From cerium to lutetium, three structural types are observed: Type I, [Ln(L)(O,O′-pic)](pic), Ln=Ce–Dy Type II, [Ln(L)(O-pic)](pic), Ln=Tb, Ho Type III, [Ln(L)(HOEt)](pic)2, Ln=Er–Lu. With lanthanum, three different ten-coordinate complexes were characterised [Ln(L)(O,O′-pic)(HOEt)](pic), [Ln(L)(O,O′-pic)(OH2)](pic), and [Ln(L)(O,O′-pic)(HOMe)](pic). The crystallisation of Type I and II observed for terbium shows that the stability of the different structures are sensitively poised at the transition points. Nevertheless, the structures show that the vacant space in the coordination sphere left by the trisamide L tends to reduce across the series as expected. It is occupied by a bidentate picrate anion and unidentate solvent molecule with lanthanum, a bidentate picrate anion for cerium to dysprosium (Type I), a unidentate picrate anion for terbium and holmium (Type II), and finally a unidentate solvent molecule from erbium to lutetium (Type III). The coordination number thus reduces from 10 to 8 across the series.
Laser-Based Formation of Copper Nanoparticles in Aqueous Solution: Optical Properties, Particle Size Distributions, and Formation Kinetics
Publisher: CSIRO Publishing
Date: 2017
DOI: 10.1071/CH17363
Abstract: We explore the formation kinetics, optical absorption spectra, and particle size distributions of copper nanoparticles (CuNPs) formed by direct laser ablation from the bulk metal via a process we refer to as Laser Ablation Synthesis in Solution (LASiS). Comparisons are made between CuNPs formed in pure water versus those formed in the presence of 1 × 10−4 M solutions of the N-donor ligands 4,4′-bipyridine (4,4′Bipy) and 1H-5-(4-pyridyl)tetrazole (T-4Py). CuNPs formed in pure water and in the presence of 4,4′Bipy display similar UV-visible absorption spectra and very similar particle size distributions. In comparison, CuNPs formed in the presence of T-4Py display significantly different absorption properties, with the surface plasmon resonance transition blue-shifted by ∼55 nm, and a much smaller and narrower particle size distribution compared with the former s les. Based on previous literature reports, it is possible to ascribe these differences to differences in the CuNP surface oxidation states for s les prepared in the presence of T-4Py. However, an analysis of the formation kinetics of all three s les indicates near-identical behaviour.
Investigating Intracellular Localisation and Cytotoxicity Trends for Neutral and Cationic Iridium Tetrazolato Complexes in Live Cells
Publisher: Wiley
Date: 07-08-2017
Abstract: A family of five neutral cyclometalated iridium(III) tetrazolato complexes and their methylated cationic analogues have been synthesised and characterised. The complexes are distinguished by variations of the substituents or degree of π conjugation on either the phenylpyridine or tetrazolato ligands. The photophysical properties of these species have been evaluated in organic and aqueous media, revealing predominantly a solvatochromic emission originating from mixed metal-to-ligand and ligand-to-ligand charge transfer excited states of triplet multiplicity. These emissions are characterised by typically long excited-state lifetimes (∼hundreds of ns), and quantum yields around 5-10 % in aqueous media. Methylation of the complexes caused a systematic red-shift of the emission profiles. The behaviour and the effects of the different complexes were then examined in cells. The neutral species localised mostly in the endoplasmic reticulum and lipid droplets, whereas the majority of the cationic complexes localised in the mitochondria. The amount of complexes found within cells does not depend on lipophilicity, which potentially suggests erse uptake mechanisms. Methylated analogues were found to be more cytotoxic compared to the neutral species, a behaviour that might to be linked to a combination of uptake and intracellular localisation.
Rhenium(I)-tetrazolato functional luminescent polymers: Organic-inorganic hybrids via RAFT and post-polymerization modification
Publisher: Elsevier BV
Date: 03-2020
Accessing Lanthanide‐to‐Lanthanide Energy Transfer in a Family of Site‐Resolved [LnIIILnIII′] Heterodimetallic Complexes
Publisher: Wiley
Date: 08-03-2021
Metal-based antitumor compounds: beyond cisplatin
Publisher: Future Science Ltd
Date: 2019
Abstract: Despite improvements in the 5-year survival rate to over 80% in cancers, such as Hodgkin lymphoma and testicular cancer, more aggressive tumors including pancreatic and brain cancer still have extremely low survival rates. The establishment of chemoresistance, responsible for the reduction in treatment efficiency and cancer relapse, is one possible explanation for this setback. Metal-based compounds, a class of anticancer drugs, are largely used in the treatment of cancer. Herein, we will review the use of metal-based small molecules in chemotherapy, focusing on recent studies, and we will discuss how new nonplatinum-based agents are prompting scientists to increase drug specificity to overcome chemoresistance in cancer cells.
Lanthanoid Coordination with a Tetrazole-Substituted Calix[4]diquinone and Calix[4]dihydroquinone
Publisher: American Chemical Society (ACS)
Date: 10-04-2019
DOI: 10.26434/CHEMRXIV.7970879.V1
Abstract: The tetrazole-functionalised calixdiquinone 5,17-di-tert-butyl-26,28-bis-(tetrazol-5-ylmethoxy)- calix[4]-25,27-diquinone Q was synthesised by chemical oxidation of the bis-tetrazole calix[4]arene precursor using PbO2/HClO4. The single crystal X-ray structure determination of Q confirmed the structure and showed binding of a water molecule in the solid state. Chemical reduction of Q to the dihydroquinone QR was achieved using N,N-diethylhydroxylamine. Comparison of the solution phase photophysical properties of Q or QR in the presence of terbium ions showed significant excitation only with QR, suggesting redox switching of the photophysical response may be possible with this or similar receptors.
Naphthalene flanked diketopyrrolopyrrole based organic semiconductors for high performance organic field effect transistors
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8NJ01453A
Abstract: A newly reported alkylated naphthalene flanked DPP monomers without any further functionalization show high hole mobility in OFET devices.
Synthesis and structural characterisation of cationic, neutral and hydroxo-bridged lanthanoid (La, Gd, Ho, Yb, Y) bis 5-(2-pyridyl)tetrazolate complexes
Publisher: Elsevier BV
Date: 11-2007
Ligand-Mediated Control of the Surface Oxidation States of Copper Nanoparticles Produced by Laser Ablation
Publisher: American Chemical Society (ACS)
Date: 30-03-2023
Probing the effect of β-triketonates in visible and NIR emitting lanthanoid complexes
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8DT00945G
Abstract: Investigating the effect of the third ketone arm on the photophysics of visible and NIR emitting lanthanoid β-triketonate complexes.
Mapping sub-cellular protein aggregates and lipid inclusions using synchrotron ATR-FTIR microspectroscopy
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1AN00136A
Abstract: SR-ATR-FTIR has been used to improve the diffraction limited spatial resolution of infrared micro-spectroscopy, enabling this study to reveal the sub-cellular location of protein aggregates and lipophilic inclusions in brain cells, and bacteria.
Effect of Rhenium(i) Complexation on Aza-Michael Additions to 5-Amino-1,10-Phenanthroline with [ 18 F]Ethenesulfonyl Fluoride towards PET Optical Tracer Development
Publisher: CSIRO Publishing
Date: 2019
DOI: 10.1071/CH18512
Abstract: Conjugations with the recently developed [18F]ethenesulfonyl fluoride ([18F]ESF) were performed on 5-amino-1,10-phenanthroline, in its free form and coordinated to a rhenium(i) tricarbonyl complex, as a means of radiosynthesizing dual-modal optical and positron emission tomography (PET) tracers. The Michael-donating ability of the aromatic amine was noticeably perturbed on coordination with the rhenium(i) centre, resulting in decreased radiochemical yields from 34%, in the case of the free ligand, to 1%. We attribute the decreased nucleophilicity of the amine to metal deactivation from the electron-withdrawing feature of the rhenium(i) tricarbonyl centre, based on spectroscopic and computational evidence, thus highlighting this effect as a crucial parameter in designing late-stage metal coordination methods employing related aza-Michael additions. Photophysical analyses were also performed on the ESF-conjugated rhenium(i) complex, exhibiting a longer decay lifetime from the triplet metal-to-ligand charge transfer excited state when compared with the non-conjugated analogue.
Photophysical investigation of near infrared emitting lanthanoid complexes incorporating tris(2-naphthoyl)methane as a new antenna ligand
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8DT04749A
Abstract: Study of a series of lanthanoid complexes reveals that ancillary ligands play a significant role in their photophysical properties.
Magnetic Information Storage on Polymers by Using Patterned Single‐Molecule Magnets
Publisher: Wiley
Date: 25-01-2005
Luminescent Lanthanoid Calixarene Complexes and Materials
Publisher: MDPI AG
Date: 28-11-2017
DOI: 10.3390/MA10121369
Abstract: This review aims to provide an overview of recent ex les of lanthanoid-calixarene complexes incorporated into light-emitting materials. Background information on the antenna effect and early work on lanthanoid complexes on calixarenes is provided to set the context. Classes of materials discussed include polymers, nanoparticles, and metal clusters.
Calcium oxalate crystal growth modification; investigations with confocal Raman microscopy
Publisher: Elsevier BV
Date: 06-2017
Photophysical and Biological Properties of Iridium Tetrazolato Complexes Functionalised with Fatty Acid Chains
Publisher: MDPI AG
Date: 26-03-2020
DOI: 10.3390/INORGANICS8040023
Abstract: Five cyclometalated Ir(III) tetrazolato complexes functionalised with fatty acid chains (octanoic, palmitic, stearic, palmitoleic, and oleic) have been synthesised. The fatty acids were chosen to evaluate the potential effect of the length and degree of unsaturation on the biological properties of the complexes for use as cellular imaging agents. The complexes were analysed in both organic and aqueous media to determine if the presence and nature of the fatty acid chains had a significant effect on their photophysical properties. The complexes display green–yellow emission in dichloromethane solutions with relatively long excited state decays, within the range 360–393 ns, and quantum yields between 5.4% and 6.7% (from degassed solutions). Temperature-dependent photophysical studies suggest that the emitting excited states of the complexes might be quenched by the thermal population of dark states. In water, the quantum yields drop within the range of 0.5%–2.4%, and the photophysical measurements are influenced by the variable degrees of aggregation. In general, the entire series displayed low cytotoxicity and relatively high photostability, which are favourable attributes in the design of cellular imaging agents. Images of live HeLa cells were obtained for all the complexes, but those functionalised with palmitic and stearic acids had limitations due the lower solubility conferred by the saturated aliphatic chains. The complexes were mainly detected within the endoplasmic reticulum.
Rhenium(I) conjugates as tools for tracking cholesterol in cells
Publisher: Oxford University Press (OUP)
Date: 2022
Abstract: Cholesterol is vital to control membrane integrity and fluidity, but is also a precursor to produce steroid hormones, bile acids, and vitamin D. Consequently, altered cholesterol biology has been linked to many diseases, including metabolic syndromes and cancer. Defining the intracellular pools of cholesterol and its trafficking within cells is essential to understand both normal cell physiology and mechanisms of pathogenesis. We have synthesized a new cholesterol mimic (ReTEGCholestanol), comprising a luminescent rhenium metal complex and a cholestanol targeting unit, linked using a tetraethylene glycol (TEG) spacer. ReTEGCholestanol demonstrated favourable imaging properties and improved water solubility when compared to a cholesterol derivative, and structurally related probes lacking the TEG linker. A non-malignant and three malignant prostate cell lines were used to characterize the uptake and intracellular distribution of ReTEGCholestanol. The ReTEGCholestanol complex was effectively internalized and mainly localized to late endosomes/lysosomes in non-malignant PNT1a cells, while in prostate cancer cells it also accumulated in early endosomes and multivesicular bodies, suggesting disturbed cholesterol biology in the malignant cells. The ReTEGCholestanol is a novel imaging agent for visualizing endosomal uptake and trafficking, which may be used to define cholesterol related biology including membrane integration and altered lipid trafficking rocessing.
Erratum: Metal complexes as a promising source for new antibiotics (Chem. Sci. (2020) 11 (2627-2639) DOI: 10.1039/c9sc06460e)
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0SC90075C
Abstract: Correction for ‘Metal complexes as a promising source for new antibiotics’ by Angelo Frei et al. , Chem. Sci. , 2020, 11 , 2627–2639.
Photophysical and Photochemical Trends in Tricarbonyl Rhenium(I) N-Heterocyclic Carbene Complexes
Publisher: American Chemical Society (ACS)
Date: 25-03-2014
DOI: 10.1021/IC403138A
Abstract: A family of tricarbonyl Re(I) complexes of the formulation fac-[Re(CO)3(NHC)L] has been synthesized and characterized, both spectroscopically and structurally. The NHC ligand represents a bidentate N-heterocyclic carbene species where the central imidazole ring is substituted at the N3 atom by a butyl, a phenyl, or a mesityl group and substituted at the N1 atom by a pyridyl, a pyrimidyl, or a quinoxyl group. On the other hand, the ancillary L ligand alternates between chloro and bromo. For the majority of the complexes, the photophysical properties suggest emission from the lowest triplet metal-to-ligand charge transfer states, which are found partially mixed with triplet ligand-to-ligand charge transfer character. The nature and relative energy of the emitting states appear to be mainly influenced by the identity of the substituent on the N3 atom of the imidazole ring thus, the pyridyl complexes have blue-shifted emission in comparison to the more electron deficient pyrimidyl complexes. The quinoxyl complexes show an unexpected blue-shifted emission, possibly occurring from ligand-centered excited states. No significant variations were found upon changing the substituent on the imidazole N3 atom and/or the ancillary ligand. The photochemical properties of the complexes have also been investigated, with only the complexes bound to the pyridyl-substituted NHC ligands showing photoinduced CO dissociation upon excitation at 370 nm, as demonstrated by the change in the IR and NMR spectra as well as a red shift in the emission profile after photolysis. Temperature-dependent photochemical experiments show that CO dissociation occurs at temperatures as low as 233 K, suggesting that the Re-C bond cleaves from excited states of metal-to-ligand charge transfer nature rather than thermally activated ligand field excited states. A photochemical mechanism that takes into account the reactivity of the complexes bound to the pyridyl-NHC ligand as well as the stability of those bound to the pyrimidyl- and quinoxyl-NHC ligands is proposed.
Synthesis, structure and conformational mobility of tetra-substituted cyanomethoxy p-tert-butylcalix[4]arenes
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6RA05865E
Abstract: A range of p-tert -butylcalix[4]arenes are functionalized at the lower rim with nitrile and amide functional groups, and the conformational mobility of macrocycles is investigated.
Lanthanoid tetrazole coordination complexes
Publisher: Elsevier BV
Date: 11-2018
Photoactive Metal Carbonyl Complexes Bearing N-Heterocyclic Carbene Ligands: Synthesis, Characterization, and Viability as Photoredox Catalysts
Publisher: American Chemical Society (ACS)
Date: 13-01-2022
DOI: 10.1021/ACS.INORGCHEM.1C02964
Abstract: This report details the synthesis and characterization of a small family of previously unreported, structurally related chromium, molybdenum, tungsten, manganese, and iron complexes bearing N-heterocyclic carbene and carbonyl supporting ligands. These complexes have the general form [ML(CO)
2,7- and 4,9-Dialkynyldihydropyrene Molecular Switches: Syntheses, Properties, and Charge Transport in Single-Molecule Junctions
Publisher: American Chemical Society (ACS)
Date: 29-06-2022
DOI: 10.1021/JACS.2C02289
Abstract: This paper describes the syntheses of several functionalized dihydropyrene (DHP) molecular switches with different substitution patterns. Regioselective nucleophilic alkylation of a 5-substituted dimethyl isophthalate allowed the development of a workable synthetic protocol for the preparation of 2,7-alkyne-functionalized DHPs. Synthesis of DHPs with surface-anchoring groups in the 2,7- and 4,9-positions is described. The molecular structures of several intermediates and DHPs were elucidated by X-ray single-crystal diffraction. Molecular properties and switching capabilities of both types of DHPs were assessed by light irradiation experiments, spectroelectrochemistry, and cyclic voltammetry. Spectroelectrochemistry, in combination with density functional theory (DFT) calculations, shows reversible electrochemical switching from the DHP forms to the cyclophanediene (CPD) forms. Charge-transport behavior was assessed in single-molecule scanning tunneling microscope (STM) break junctions, combined with density functional theory-based quantum transport calculations. All DHPs with surface-contacting groups form stable molecular junctions. Experiments show that the molecular conductance depends on the substitution pattern of the DHP motif. The conductance was found to decrease with increasing applied bias.
Colourless luminescent solar concentrators based on Iridium(III)-Phosphors
Publisher: Elsevier BV
Date: 09-2021
Further insight into the coordination of 2,5-dicarbothioamidopyrroles: the case of Cu and Co complexes
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C1DT10441A
Abstract: The coordination chemistry of 2,5-dicarbothioamidopyrrole ligands, namely N2,N5-dibutyl-3,4-diphenyl-1H-pyrrole-2,5-bis(carbothioamide) and N2,N5,3,4-tetraphenyl-1H-pyrrole-2,5-bis(carbothioamide), has been investigated with Cu(II) metal centres by means of X-ray crystallography. This resulted in the formation of the expected planar S,N,S' coordinated complex for the former ligand and unexpected ring-closure reactions, with formation of benzothiazole sidearms, for the latter. Both Cu(II) and Cu(I), used in large excess, were found to favour the ring-closure reaction, although the structural characterisation of the resulting complexes contained only Cu(II) cations, with varying coordination geometries ranging from square planar and square-based pyramidal to tetrahedral. By repeating the reaction using a slight excess of Cu(II) (2 : 1) two more different structures were obtained where the metal was coordinated to the original ligand, N2,N5,3,4-tetraphenyl-1H-pyrrole-2,5-bis(carbothioamide), or to the mixed ligand where only one of the thioamide substituents had converted to a benzothiazole. The essential role of Cu for the ring closure reaction was also established by comparing its complex with structural features of the analogous Co(II) complex, the latter revealing no ring closure to give benzothiazole substituents and co-crystallisation of a mixed Co(II)/Co(III) complex. Finally, the structure and photophysical properties of the corresponding 3,4-diphenyl-2,5-bis(benzothiozol-5-yl)-pyrrole ligand, obtained via treatment of the thioamide with K(3)[Fe(CN)(6)], were also investigated revealing a blue-centered emission.
Variation of structural motifs in lanthanoid hydroxo clusters by ligand modification
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C2NJ40560A
Anionic Cyclometalated Platinum(II) Tetrazolato Complexes as Viable Photoredox Catalysts
Publisher: American Chemical Society (ACS)
Date: 28-02-2019
Functionalised β-diketonate polynuclear lanthanoid hydroxo clusters: Synthesis, characterisation, and magnetic properties
Publisher: Elsevier BV
Date: 07-2009
In situ X-ray synchrotron study of organic semiconductor ultra-thin films growth
Publisher: Elsevier BV
Date: 05-2006
Mitochondrial imaging in live or fixed tissues using a luminescent iridium complex
Publisher: Springer Science and Business Media LLC
Date: 29-05-2018
DOI: 10.1038/S41598-018-24672-W
Abstract: Mitochondrial morphology is important for the function of this critical organelle and, accordingly, altered mitochondrial structure is exhibited in many pathologies. Imaging of mitochondria can therefore provide important information about disease presence and progression. However, mitochondrial imaging is currently limited by the availability of agents that have the capacity to image mitochondrial morphology in both live and fixed s les. This can be particularly problematic in clinical studies or large, multi-centre cohort studies, where tissue archiving by fixation is often more practical. We previously reported the synthesis of an iridium coordination complex [Ir( ppy ) 2 ( MeTzPyPhCN )] + where ppy is a cyclometalated 2-phenylpyridine and TzPyPhCN is the 5-(5-(4-cyanophen-1-yl)pyrid-2-yl)tetrazolate ligand and showed that this complex (herein referred to as IraZolve-Mito) has a high specificity for mitochondria in live cells. Here we demonstrate that IraZolve-Mito can also effectively stain mitochondria in both live and fixed tissue s les. The staining protocol proposed is versatile, providing a universal procedure for cell biologists and pathologists to visualise mitochondria.
A fluorescent and solvatochromic 1,8-naphthalimide probe for detection of lipid droplet trafficking and biogenesis
Publisher: Elsevier BV
Date: 09-2023
A (2-(naphthalen-2-yl)phenyl)rhodium(i ) complex formed by a proposed intramolecular 1,4-ortho-to-ortho′ Rh metal-atom migration and its efficacy as an initiator in the control
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9DT02953B
Abstract: This contribution details the synthesis of a new Rh( i )-aryl complex and the first ex le in which such a complex is employed as an initiator in the controlled polymerisation of phenylacetylene.
Templated assembly of a µ6-CO32– dodecanuclear lanthanum dibenzoylmethanide hydroxido cluster with concomitant formation of phenylglyoxylate
Publisher: Royal Society of Chemistry (RSC)
Date: 2007
DOI: 10.1039/B710534G
Abstract: Reaction of LaCl(3) and dibenzoylmethane (Ph(2)acacH) in methanol with an excess of triethylamine resulted in the unexpected formation of a dodecanuclear hydroxo-bridged La cluster templated by CO(3)(2-) and phenylglyoxylate (Phgly), as determined by X-ray crystallography.
Comparison of the impact of ozone, chlorine dioxide, ferrate and permanganate pre-oxidation on organic disinfection byproduct formation during post-chlorination
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0EW00411A
Abstract: Pre-oxidation is commonly used to mitigate the formation of byproducts during post-disinfection.
Metal Complexes as a Promising Source for New Antibiotics
Publisher: American Chemical Society (ACS)
Date: 22-10-2019
DOI: 10.26434/CHEMRXIV.9956744
Abstract: There is a dire need for new classes of antimicrobial compounds to combat the growing threat of widespread antibiotic resistance. With a currently very scarce drug pipeline, consisting mostly of derivatives of known antibiotics, new classes of antibiotics are urgently required. Antibiotic compounds are notorious for not having very “drug-like” chemical structures. Metal complexes are currently in clinical development for the treatment of cancer, malaria and neurodegenerative diseases. However, only little attention has been paid to their application as potential antimicrobial compounds. We report the evaluation of 906 metal-containing compounds that have been screened by the Community for Open Antimicrobial Drug Discovery (CO-ADD) for antimicrobial activity. Metal-bearing compounds display a significantly higher hit-rate (9.9%) when compared to the purely organic molecules (0.87%) in the CO-ADD database. Out of 906 compounds, 88 show activity against at least one of the tested strains, including fungi, while not displaying any cytotoxicity against mammalian cell lines or haemolytic properties. Herein, we highlight the structures of the 30 compounds with activity against Gram-positive and/or Gram-negative bacteria containing Mn, Co, Zn, Ru, Ag, Eu, Ir and Pt, with activities down to the nanomolar range against methicillin resistant i S. aureus /i (MRSA). This work reveals the vast ersity that metal-containing compounds can bring to antimicrobial research. It is important to raise awareness of these types of compounds for the design of truly novel antibiotics with potential for combatting antimicrobial resistance.
Methylation of Ir(iii )-tetrazolato complexes: an effective route to modulate the emission outputs and to switch to antimicrobial properties
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7DT02352A
Abstract: The conversion of neutral to cationic Ir( iii ) tetrazolato complexes enables the red-shift of emission and the switch-on of antibacterial properties against Gram(+) D. radiodurans .
A rhodamine–naphthalimide–benzamide trichromophoric system with solid-state and multiple solvent dependent aggregate emissive properties
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1QM00397F
Abstract: The readily synthesised rhodamine–naphthalimide–benzamide trichromophoric system forms unique AIE emissive species in DMSO solutions with traces of water ( %) and high water content ( %) and responds to pH changes in both solution and solid state.
Targeting divalent metal cations with Re(i ) tetrazolato complexes
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5DT03690A
Abstract: The design, preparation and characterization of four new Re( i ) tetrazolato complexes together with the study of their luminescent sensing abilities toward Zn( ii ), Cd( ii ) and Cu( ii ) are described herein.
Toward Amorphous Conductors: Enhanced Conductivity of Doped Polyaniline via Interchain Crosslinking Promoted by Acid-Functionalized Aluminum Quinolines
Publisher: Wiley
Date: 17-10-2006
Anionic Cyclometallated platinum(II) Tetrazolato Complexes as Viable Photoredox Catalysts
Publisher: American Chemical Society (ACS)
Date: 17-12-2018
DOI: 10.26434/CHEMRXIV.7472051.V1
Abstract: The synthesis, characterization, photophysical and photocatalytic studies of anionic platinum(II) tetrazolato complexes, with the general structure [TBA][Pt(CNC)TzR], are reported, where CNC 2- represents a doubly cyclometalated 2,4,6-triphenylpyridine, TzR - is an anionic 5-substituted tetrazolato ligand (with a variable R functional group) and TBA + is the tetrabutylammonium countercation. The complexes were prepared by substitution of the DMSO ligand in [Pt(CNC)(DMSO)] with the corresponding tetrazolato ligand. No emission from the platinum(II) complexes was detected at room temperature in solution, but the photophysical properties could be assessed in the solid state, where all the complexes display emission bands attributed to aggregates. The platinum(II) complexes were found to facilitate a range of fundamental classes of visible-light-mediated photoredox-catalyzed reactions, including α‑amino C–H functionalization processes, such as Povarov-type reactions and the addition of α-amino C–H bonds across Michael acceptors, in addition to ATRA chemistry, and a hydrodeiodination. With the exception of the hydrodeiodination process, the best Pt(II) catalysts provided turnover numbers of 150–175 in each of these transformations.
Versatility of Terpyridine-Functionalised Aryl Tetrazoles: Photophysical Properties, Ratiometric Sensing of Zinc Cations and Sensitisation of Lanthanide Luminescence
Publisher: Wiley
Date: 16-10-2017
Water soluble lanthanoid benzoate complexes for the kinetic separation of cis/trans-limonene oxide
Publisher: Elsevier BV
Date: 10-2006
Telescoping the Synthesis of the [18F]CABS13 Alzheimer's Disease Radiopharmaceutical via Flow Microfluidic Rhenium(I) Complexations
Publisher: Wiley
Date: 24-09-2020
Tricarbonyl rhenium(i) tetrazolato and N-heterocyclic carbene complexes: Versatile visible-light-mediated photoredox catalysts
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9DT02533B
Abstract: This study demonstrates that structurally- erse, photoactive rhenium( i ) tricarbonyl complexes can mediate representative atom-transfer radical addition, hydrodehalogenation, and α-amino C–H functionalisation reactions.
Neutral Re(I) Complex Platform for Live Intracellular Imaging
Publisher: American Chemical Society (ACS)
Date: 07-2021
Related Organisations
Related Funding Activities
Accessing The Therapeutic Potential Of Carbon Monoxide
Start Date: 2014
End Date: 2017
Funder: Australian Research Council
View Funded ActivityWestern Australian Advanced Fluorescence And Phosphorescence Characterisation Facility
Start Date: 2013
End Date: 2013
Funder: Australian Research Council
View Funded ActivityIlluminating Hidden Processes In Emissive Lanthanoid Complexes
Start Date: 2017
End Date: 2019
Funder: Australian Research Council
View Funded ActivityDesign And Synthesis Of Novel Lanthanoid Complexes For The Fabrication Of Light Emitting Devices
Start Date: 2009
End Date: 2012
Funder: Australian Research Council
View Funded ActivityHigh Sensitivity Superconducting Quantum Interference Device Vibrating Sample Magnetometer
Start Date: 2013
End Date: 2013
Funder: Australian Research Council
View Funded ActivityA Single-molecule Super-resolution Microscopy Facility In Western Australia
Start Date: 2016
End Date: 2016
Funder: Australian Research Council
View Funded ActivityMultiphoton Confocal Microscope For High-speed, Deep Tissue Imaging And Multimodal Nanoscale Characterisation
Start Date: 2011
End Date: 2011
Funder: Australian Research Council
View Funded ActivityLinkage Infrastructure, Equipment And Facilities - Grant ID: LE130100143
Start Date: 2013
End Date: 12-2014
Amount: $320,000.00
Funder: Australian Research Council
View Funded ActivityDiscovery Projects - Grant ID: DP170101895
Start Date: 03-2017
End Date: 12-2021
Amount: $474,500.00
Funder: Australian Research Council
View Funded ActivityDiscovery Projects - Grant ID: DP0985481
Start Date: 2009
End Date: 12-2012
Amount: $260,000.00
Funder: Australian Research Council
View Funded ActivityLinkage Infrastructure, Equipment And Facilities - Grant ID: LE130100052
Start Date: 2013
End Date: 12-2013
Amount: $170,000.00
Funder: Australian Research Council
View Funded ActivityLinkage Infrastructure, Equipment And Facilities - Grant ID: LE110100146
Start Date: 2011
End Date: 12-2012
Amount: $500,000.00
Funder: Australian Research Council
View Funded ActivityARC Future Fellowships - Grant ID: FT130100033
Start Date: 2014
End Date: 12-2018
Amount: $705,120.00
Funder: Australian Research Council
View Funded ActivityLinkage Infrastructure, Equipment And Facilities - Grant ID: LE160100086
Start Date: 05-2016
End Date: 12-2016
Amount: $850,000.00
Funder: Australian Research Council
View Funded ActivityLinkage Infrastructure, Equipment And Facilities - Grant ID: LE190100183
Start Date: 04-2019
End Date: 04-2020
Amount: $415,000.00
Funder: Australian Research Council
View Funded ActivityDiscovery Projects - Grant ID: DP220103091
Start Date: 10-2022
End Date: 09-2025
Amount: $420,000.00
Funder: Australian Research Council
View Funded ActivityLinkage Infrastructure, Equipment And Facilities - Grant ID: LE200100122
Start Date: 08-2020
End Date: 08-2021
Amount: $620,000.00
Funder: Australian Research Council
View Funded ActivityLinkage Infrastructure, Equipment And Facilities - Grant ID: LE210100124
Start Date: 07-2021
End Date: 06-2024
Amount: $538,590.00
Funder: Australian Research Council
View Funded Activity