ORCID Profile
0000-0001-5506-0308
Current Organisations
Monash University
,
UNSW Sydney
,
University of Stavanger
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: American Chemical Society (ACS)
Date: 30-01-2019
Abstract: Graphene oxide (GO) membranes assembled by GO nanosheets exhibit high water flux because of the unique water channels formed by their functionalized layer-by-layer structure. Although water transport in the GO membrane is in principle influenced by the functional groups at the edges of GO nanosheets, this is yet to be fully understood. To fill this knowledge gap, molecular dynamics simulation was employed in this work to gain insights into the influences of three typical edge functional groups of GO nanosheets: carboxyl (COOH), hydroxyl (OH), and hydrogen (H). A well-controlled numerical analysis with complete isolation of the functional groups at the edges was undertaken. The results reveal that the COOH group has a negative impact on water transport because of its relatively large steric geometric structure, which resists water flow. By contrast, the OH group promotes water transport by uniquely "pulling" water molecules across the nanosheet layer because of its relatively stronger interaction with water. The H atom promotes water transport as well, mainly because of its low-resistance steric structure. Moreover, the size of the inter-edge hub has an apparent impact on the influence of these functional groups on water transport. The results suggest that in the design of high water flux GO membranes, it would be strategic to remove COOH edge functional groups while maintaining a mixture of OH and H edge functional groups.
Publisher: Elsevier BV
Date: 10-2012
Publisher: Wiley
Date: 29-03-2017
DOI: 10.1002/AIC.15713
Publisher: Informa UK Limited
Date: 25-11-2014
DOI: 10.3109/03602532.2013.859688
Abstract: Engineered nanoparticles (ENP), which could be composed of inorganic metals, metal oxides, metalloids, organic biodegradable and inorganic biocompatible polymers, are being used as carriers for vaccine and drug delivery. There is also increasing interest in their application as delivery agents for the treatment of a variety of lung diseases. Although many studies have shown ENP can be effectively and safely used to enhance the delivery of drugs and vaccines in the periphery, there is concern that some ENP could promote inflammation, with unknown consequences for lung immune homeostasis. In this study, we review research on the effects of ENP on lung immunity, focusing on recent studies using erse animal models of human lung disease. We summarize how the inflammatory and immune response to ENP is influenced by the erse biophysical and chemical characteristics of the particles including composition, size and mode of delivery. We further discuss newly described unexpected beneficial properties of ENP administered into the lung, where biocompatible polystyrene or silver nanoparticles can by themselves decrease susceptibility to allergic airways inflammation. Increasing our understanding of the differential effects of erse types of nanoparticles on pulmonary immune homeostasis, particularly previously underappreciated beneficial outcomes, supports rational ENP translation into novel therapeutics for prevention and/or treatment of inflammatory lung disorders.
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: Springer Science and Business Media LLC
Date: 13-02-2013
Publisher: Ivyspring International Publisher
Date: 2017
DOI: 10.7150/THNO.16866
Publisher: Elsevier BV
Date: 02-2019
Publisher: Elsevier BV
Date: 03-2019
Publisher: WORLD SCIENTIFIC
Date: 25-12-2013
Publisher: MDPI AG
Date: 27-02-2020
DOI: 10.3390/IJMS21051613
Abstract: Despite developments in pulmonary radiotherapy, radiation-induced lung toxicity remains a problem. More sensitive lung imaging able to increase the accuracy of diagnosis and radiotherapy may help reduce this problem. Super-paramagnetic iron oxide nanoparticles are used in imaging, but without further modification can cause unwanted toxicity and inflammation. Complex carbohydrate and polymer-based coatings have been used, but simpler compounds may provide additional benefits. Herein, we designed and generated super-paramagnetic iron oxide nanoparticles coated with the neutral natural dietary amino acid glycine (GSPIONs), to support non-invasive lung imaging and determined particle biodistribution, as well as understanding the impact of the interaction of these nanoparticles with lung immune cells. These GSPIONs were characterized to be crystalline, colloidally stable, with a size of 12 ± 5 nm and a hydrodynamic diameter of 84.19 ± 18 nm. Carbon, Hydrogen, Nitrogen (CHN) elemental analysis estimated approximately 20.2 × 103 glycine molecules present per nanoparticle. We demonstrated that it is possible to determine the biodistribution of the GSPIONs in the lung using three-dimensional (3D) ultra-short echo time magnetic resonance imaging. The GSPIONs were found to be taken up selectively by alveolar macrophages and neutrophils in the lung. In addition, the GSPIONs did not cause changes to airway resistance or induce inflammatory cytokines. Alveolar macrophages and neutrophils are critical regulators of pulmonary inflammatory diseases, including allergies, infections, asthma and chronic obstructive pulmonary disease (COPD). Therefore, pulmonary Magnetic Resonance (MR) imaging and preferential targeting of these lung resident cells by our nanoparticles offer precise imaging tools, which can be utilized to develop precision targeted radiotherapy as well as diagnostic tools for lung cancer, thereby having the potential to reduce the pulmonary complications of radiation.
Publisher: American Chemical Society (ACS)
Date: 21-01-2016
Publisher: Elsevier BV
Date: 11-2016
Publisher: Elsevier BV
Date: 11-2020
Publisher: Elsevier BV
Date: 11-2016
Publisher: Elsevier BV
Date: 07-2023
Publisher: Elsevier BV
Date: 10-2019
Publisher: American Chemical Society (ACS)
Date: 07-10-2011
DOI: 10.1021/LA203249V
Abstract: Microencapsulates with defined core-shell structures are of interest for applications, such as controlled release and encapsulation, because of the feasibility of fine-tuning in idual functionalities of different parts. Here, we report a new approach for efficient and scalable production of such particles. Eudragit RS (a co-polymer of ethyl acrylate, methyl methacrylate, and a low content of methacrylic acid ester with quaternary ammonium groups) was used as the main shell component, with silica as the core component, formed upon a single-step spray-drying assembly. The method is capable of forming uniform core-shell particles from homogeneous precursors without the use of any organic solvents. Evaporation-induced self-assembly attained the phase separation among different components during drying, resulting in the core-shell spatial configuration, while precise control over particle uniformity was accomplished via a microfluidic jet spray dryer. Direct control over shell thickness can be achieved from the ratio of the core and shell ingredients in the precursors. A fluorescent compound, rhodamine B, is used as a highly water-soluble model component to investigate the controlled release properties of these microencapsulates, with the release behaviors shown to be significantly dependent upon their architectures.
Publisher: Elsevier BV
Date: 04-2012
Publisher: Informa UK Limited
Date: 24-04-2012
DOI: 10.3109/02652048.2012.680510
Abstract: Particulates for pharmaceutical applications require stringent control over their characteristics to realize the optimal therapeutic performance. By generating uniform spray-dried silica particles encapsulating different model drugs via a microfluidic jet spray drying technique, we demonstrated how the effects of formulation and process parameters on the investigated properties could be directly quantified without the complications of wide particle distributions typical of conventional spray drying. The implemented strategies included incorporating lactose to modify the internal microstructures to regulate release, and increasing drying temperature during synthesis to modify the surface features of particles. The physicochemical properties of encapsulated drugs were shown to influence particle morphologies and release profiles, while the pH of initial precursors influenced the particle morphologies with slight effects on the initial release rates. The outcomes would be useful to indentify appropriate formulations and manufacturing parameters in designing spray-dried silica-based microencapsulates with tailor-made controlled release functionalities.
Publisher: Elsevier BV
Date: 05-2013
DOI: 10.1016/J.JCONREL.2013.02.030
Abstract: We investigated the efficacy and types of immune responses from plasmid malaria DNA vaccine encoding VR1020-PyMSP119 condensed on the surface of polyethyleneimine (PEI)-coated SPIONs. In vivo mouse studies were done firstly to determine the optimum magnetic vector composition, and then to observe immune responses elicited when magnetic vectors were introduced via different administration routes. Higher serum antibody titers against PyMSP119 were observed with intraperitoneal and intramuscular injections than subcutaneous and intradermal injections. Robust IgG2a and IgG1 responses were observed for intraperitoneal administration, which could be due to the physiology of peritoneum as a major reservoir of macrophages and dendritic cells. Heterologous DNA prime followed by single protein boost vaccination regime also enhanced IgG2a, IgG1, and IgG2b responses, indicating the induction of appropriate memory immunity that can be elicited by protein on recall. These outcomes support the possibility to design superparamagnetic nanoparticle-based DNA vaccines to optimally evoke desired antibody responses, useful for a variety of diseases including malaria.
Publisher: Elsevier BV
Date: 07-2015
DOI: 10.1016/J.FOODCHEM.2015.01.081
Abstract: The characteristics of glutelin s les from Akebia trifoliata var. australis seeds (AG) that had been deamidated by malic acid (MDAG) and by citric acid (CDAG) were investigated. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed high-molecular-weight subunits that were degraded into smaller fragments, and FTIR indicated a decrease in the number of β-sheet groups and an increase in the amount of β-turns in the deamidated s les. These results could be caused by the cleaving of partial disulfide bonds to form new sulfhydryl groups during deamidation. Citric acid was found to be more effective at deamidation and hydrolysis, resulting in a higher solubility and emulsifying activity for CDAG, and MDAG also exhibited some improvement in terms of surface hydrophobicity and emulsion ability. Rheology showed that the gelation point for deamidated s les was increased, and the gel network was strengthened. The amounts of essential amino acids that were well-preserved and the improved solubility, emulsification, and rheology properties of AG after acid-heating deamidation show that this technique can be useful for treating other plant-based food ingredients in the future.
Publisher: Elsevier BV
Date: 11-2023
Publisher: Elsevier BV
Date: 11-2013
Publisher: Elsevier BV
Date: 09-2022
Publisher: Elsevier BV
Date: 05-2019
DOI: 10.1016/J.FOODCHEM.2018.12.074
Abstract: This study reports on the preparation of riboflavin-loaded whey protein isolate (WPI) microparticles, using desolvation and then spray drying. Ethanol desolvation led to the exposure of embedded hydrophobic amino acids of WPI to riboflavin, facilitating the formation of riboflavin-WPI complexes. The extent of desolvation and cross-linking influenced the morphology of the spray-dried microparticles, while the moisture content of microparticles decreased with desolvation and increased with crosslinking. The modification of WPI conformation upon desolvation could be retained in the dry state via spray drying. The gastric resistance, release site and release characteristics of microparticles were readily adjusted by varying the ethanol and calcium ion contents from 0 to 50% v/v and from 0 to 2 mM, respectively. The s le prepared from 30% v/v ethanol without calcium crosslinking displayed rapid peptic digestion in less than 30 min. The s les from 30% v/v ethanol at 1 and 2 mM Ca
Publisher: Wiley
Date: 05-04-2010
DOI: 10.1002/WNAN.88
Abstract: Vaccination offers a cost-effective approach to the control of endemic infectious and a less invasive treatment modality against cancers. Since the discovery that injecting DNA encoding antigens (expressed in vivo) results in the induction of CD8 T cells as well as antibody mediated immunity, researchers have tried to develop methods to consistently enhance this immunity to disease protective levels in humans. Adsorption, coformulation, or encapsulation with particles has been found to both stabilize DNA formulations, through preventing rapid degradation, and provide vaccine adjuvanting effects, largely due to effective uptake of particulate materials by antigen presenting cells. Recently, it has been shown that nanoparticles, as opposed to microparticles, based DNA vaccine carriers are preferentially taken up by dendritic cells resulting in the induction of maximal levels of combined humoral and cellular immunity.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TA00488A
Abstract: Scalable synthesis of wrinkled mesoporous TiO 2 microspheres with uniform large micron sizes is achieved. They show excellent performance for removal of Cr( vi ).
Publisher: Informa UK Limited
Date: 26-10-2013
Publisher: Elsevier BV
Date: 2020
Publisher: American Chemical Society (ACS)
Date: 23-09-2014
DOI: 10.1021/EF5014314
Publisher: Elsevier
Date: 2017
Publisher: Elsevier BV
Date: 10-2015
Publisher: Elsevier BV
Date: 08-2019
Publisher: Informa UK Limited
Date: 03-10-2018
DOI: 10.1080/17476348.2018.1523009
Abstract: Airway inflammatory disorders are prevalent diseases in need of better management and new therapeutics. Immunotherapies offer a solution to the problem of corticosteroid resistance. Areas covered: The current review focuses on lipopolysaccharide (Gram-negative bacterial endotoxin)-mediated inflammation in the lung and the animal models used to study related diseases. Endotoxin-induced lung pathology is usually initiated by antigen presenting cells (APC). We will discuss different subsets of APC including lung dendritic cells and macrophages, and their role in responding to endotoxin and environmental challenges. Expert commentary: The pharmacotherapeutic considerations to combat airway inflammation should cost-effectively improve quality of life with sustainable and safe strategies. Selectively targeting APCs in the lung offer the potential for a promising new strategy for the better management and treatment of inflammatory lung disease.
Publisher: Springer Science and Business Media LLC
Date: 19-01-2010
DOI: 10.1051/DST/2009050
Publisher: MDPI AG
Date: 29-10-2015
Publisher: Informa UK Limited
Date: 24-04-2014
Publisher: Elsevier BV
Date: 05-2013
Publisher: Elsevier BV
Date: 07-07-2010
Publisher: Wiley
Date: 06-02-2017
DOI: 10.1002/AIC.15657
Publisher: Wiley
Date: 04-04-2017
Abstract: Smart surface coatings of silicon (Si) nanoparticles are shown to be good ex les for dramatically improving the cyclability of lithium-ion batteries. Most coating materials, however, face significant challenges, including a low initial Coulombic efficiency, tedious processing, and safety assessment. In this study, a facile sol-gel strategy is demonstrated to synthesize commercial Si nanoparticles encapsulated by amorphous titanium oxide (TiO
Publisher: Elsevier BV
Date: 07-2015
Publisher: Wiley
Date: 06-2010
Publisher: Elsevier BV
Date: 03-2012
Publisher: Elsevier BV
Date: 02-2013
DOI: 10.1016/J.COLSURFB.2012.09.026
Abstract: Superparamagnetic iron oxide nanoparticles (SPIONs) can be used as therapeutic and diagnostic agents due to their unique magnetic characteristics, provided that they are stable in physiological conditions. Here, the assembly of different magnetic vector configurations comprising SPIONs, polyethylenimine (PEI), and hyaluronic acid (HA), acting as carriers for malaria DNA vaccine encoding Plasmodium yoelii merozoite surface protein MSP1-19 (VR1020-PyMSP1-19), and their stability in different cell media were investigated. The order of assembly affected vector size, surface charge, stability, and ability to bind and release DNA. Generally, all vectors showed relatively small size of less than 200 nm in water, whereas higher degree of aggregation was observed immediately after transferring to high-ionic strength media such as 150 mM NaCl buffer and RPMI 1640 culture media (Roswell Park Memorial Institute medium). However, the pre-addition of HA to DNA effectively reduced the extent of aggregation in serum-free RPMI 1640 with sizes of almost all complexes remaining below 90 nm, particularly at HA:PEI charge ratio of 100%. The presence of fetal bovine serum (FBS) in RPMI 1640 culture media further converted the surface charge of vectors from positive to negative, decreasing the size to smaller than 50 nm. Partial disassembly of some vectors was observed in water, in RPMI, and in RPMI supplemented with 10% FBS after incubation for 1h, but not in NaCl buffer, indicating that incubation of complexes in NaCl buffer prior to transfection may limit the intracellular release of plasmid DNA. DNase sensitivity assay showed that plasmid DNA vaccine encoding the PyMSP1-19 in all configurations preserved their structural integrity without damage, even after DNase I treatment for 30 min. This study demonstrated that structurally well-defined magnetic gene carriers could be designed to improve malaria DNA vaccine delivery systems, particularly for in vivo applications.
Publisher: Wiley
Date: 20-09-2011
DOI: 10.1002/PEN.21813
Publisher: Elsevier BV
Date: 04-2011
Publisher: Elsevier BV
Date: 2019
Publisher: Informa UK Limited
Date: 28-12-2007
Publisher: MDPI AG
Date: 26-04-2023
DOI: 10.3390/GELS9050366
Abstract: Recent advances in the understanding of formulations and processing techniques have allowed for greater freedom in plant-based emulsion gel design to better recreate conventional animal-based foods. The roles of plant-based proteins, polysaccharides, and lipids in the formulation of emulsion gels and relevant processing techniques such as high-pressure homogenization (HPH), ultrasound (UH), and microfluidization (MF), were discussed in correlation with the effects of varying HPH, UH, and MF processing parameters on emulsion gel properties. The characterization methods for plant-based emulsion gels to quantify their rheological, thermal, and textural properties, as well as gel microstructure, were presented with a focus on how they can be applied for food purposes. Finally, the potential applications of plant-based emulsion gels, such as dairy and meat alternatives, condiments, baked goods, and functional foods, were discussed with a focus on sensory properties and consumer acceptance. This study found that the implementation of plant-based emulsion gel in food is promising to date despite persisting challenges. This review will provide valuable insights for researchers and industry professionals looking to understand and utilize plant-based food emulsion gels.
Publisher: Informa UK Limited
Date: 13-03-2014
Publisher: Informa UK Limited
Date: 26-05-2016
Publisher: Wiley
Date: 16-01-2012
Publisher: Informa UK Limited
Date: 11-09-2018
Publisher: American Chemical Society (ACS)
Date: 05-07-2022
Publisher: Elsevier BV
Date: 09-2017
Publisher: Elsevier BV
Date: 05-2022
Publisher: Elsevier BV
Date: 03-2020
Publisher: Elsevier BV
Date: 03-2011
DOI: 10.1016/J.COLSURFB.2010.11.001
Abstract: Particulates with specific sizes and characteristics can induce potent immune responses by promoting antigen uptake of appropriate immuno-stimulatory cell types. Magnetite (Fe(3)O(4)) nanoparticles have shown many potential bioapplications due to their biocompatibility and special characteristics. Here, superparamagnetic Fe(3)O(4) nanoparticles (SPIONs) with high magnetization value (70emug(-1)) were stabilized with trisodium citrate and successfully conjugated with a model antigen (ovalbumin, OVA) via N,N'-carbonyldiimidazole (CDI) mediated reaction, to achieve a maximum conjugation capacity at approximately 13 microgmicrom(-2). It was shown that different mechanisms governed the interactions between the OVA molecules and magnetite nanoparticles at different pH conditions. We evaluated as-synthesized SPION against commercially available magnetite nanoparticles. The cytotoxicity of these nanoparticles was investigated using mammalian cells. The reported CDI-mediated reaction can be considered as a potential approach in conjugating biomolecules onto magnetite or other biodegradable nanoparticles for vaccine delivery.
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C1SM05879G
Publisher: American Chemical Society (ACS)
Date: 03-2011
DOI: 10.1021/LA104479C
Abstract: Low efficiency is often observed in the delivery of DNA vaccines. The use of superparamagnetic nanoparticles (SPIONs) to deliver genes via magnetofection could improve transfection efficiency and target the vector to its desired locality. Here, magnetofection was used to enhance the delivery of a malaria DNA vaccine encoding Plasmodium yoelii merozoite surface protein MSP1(19) (VR1020-PyMSP1(19)) that plays a critical role in Plasmodium immunity. The plasmid DNA (pDNA) containing membrane associated 19-kDa carboxyl-terminal fragment of merozoite surface protein 1 (PyMSP1(19)) was conjugated with superparamagnetic nanoparticles coated with polyethyleneimine (PEI) polymer, with different molar ratio of PEI nitrogen to DNA phosphate. We reported the effects of SPIONs-PEI complexation pH values on the properties of the resulting particles, including their ability to condense DNA and the gene expression in vitro. By initially lowering the pH value of SPIONs-PEI complexes to 2.0, the size of the complexes decreased since PEI contained a large number of amino groups that became increasingly protonated under acidic condition, with the electrostatic repulsion inducing less aggregation. Further reaggregation was prevented when the pHs of the complexes were increased to 4.0 and 7.0, respectively, before DNA addition. SPIONs/PEI complexes at pH 4.0 showed better binding capability with PyMSP1(19) gene-containing pDNA than those at neutral pH, despite the negligible differences in the size and surface charge of the complexes. This study indicated that the ability to protect DNA molecules due to the structure of the polymer at acidic pH could help improve the transfection efficiency. The transfection efficiency of magnetic nanoparticle as carrier for malaria DNA vaccine in vitro into eukaryotic cells, as indicated via PyMSP1(19) expression, was significantly enhanced under the application of external magnetic field, while the cytotoxicity was comparable to the benchmark nonviral reagent (Lipofectamine 2000).
Publisher: Wiley
Date: 31-05-2010
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9TA04120F
Abstract: Synergistic disorder and defect engineering in ruthenium disulfide enables efficient water splitting with an ultralow cell voltage of 1.527 V.
Publisher: Springer Science and Business Media LLC
Date: 19-09-2012
Publisher: Elsevier BV
Date: 10-2019
DOI: 10.1016/J.IJPHARM.2019.118654
Abstract: The use of nanoparticles for pulmonary delivery poses challenges such as the presence of anatomical barriers and the loss of bioactive components. Excipients are often used to facilitate delivery. Excipients suitable for nanoparticle delivery are still being explored. Herein we introduce for the first time, spray-dried glycine microparticle-based excipients loaded with nanoparticles of the size range known to be taken up by alveolar macrophages. Using a microfluidic jet spray dryer, we produced glycine microparticles-based excipients which are spherical, uniform, cenospheric (hollow at core), and "coral-like" with average diameter of 60 ± 10 μm, 29 ± 0.8% porosity, and showed their effective loading with glycine coated iron oxide superparamagnetic nanoparticles (GSPIONs). Our loading protocol with nanoparticles further increased microsphere porosity and improved aerodynamic performance unlike the dense, solid commercial excipient, Lactohale200™. This demonstrates a feasible approach for delivery of such nanoparticles in the lung.
Publisher: Elsevier BV
Date: 04-2016
Publisher: WORLD SCIENTIFIC
Date: 2016
DOI: 10.1142/9677
Publisher: Elsevier BV
Date: 06-2011
Publisher: Elsevier BV
Date: 11-2012
Publisher: Elsevier BV
Date: 08-2018
Publisher: Elsevier BV
Date: 08-2016
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7NR06186B
Abstract: We successfully synthesized a novel electro-catalyst with a unique structure of Ni 2 P nanoparticles decorating the surface of MoO 2 @MoS 2 sub-microwires on titanium foil (denoted as NiMoO-SP/Ti) via a temperature-programmed sulfuration-phosphorization from its NiMoO 4 precursor.
Publisher: MDPI AG
Date: 03-11-2020
Abstract: Vaccines against blood-stage malaria often aim to induce antibodies to neutralize parasite entry into red blood cells, interferon gamma (IFNγ) produced by T helper 1 (Th1) CD4+ T cells or interleukin 4 (IL-4) produced by T helper 2 (Th2) cells to provide B cell help. One vaccine delivery method for suitable putative malaria protein antigens is the use of nanoparticles as vaccine carriers. It has been previously shown that antigen conjugated to inorganic nanoparticles in the viral-particle size range (~40–60 nm) can induce protective antibodies and T cells against malaria antigens in a rodent malaria challenge model. Herein, it is shown that biodegradable pullulan-coated iron oxide nanoparticles (pIONPs) can be synthesized in this same size range. The pIONPs are non-toxic and do not induce conventional pro-inflammatory cytokines in vitro and in vivo. We show that murine blood-stage antigen MSP4/5 from Plasmodium yoelii could be chemically conjugated to pIONPs and the use of these conjugates as immunogens led to the induction of both specific antibodies and IFNγ CD4+ T cells reactive to MSP4/5 in mice, comparable to responses to MSP4/5 mixed with classical adjuvants (e.g., CpG or Alum) that preferentially induce Th1 or Th2 cells in idually. These results suggest that biodegradable pIONPs warrant further exploration as carriers for developing blood-stage malaria vaccines.
Publisher: Elsevier BV
Date: 02-2014
Publisher: Springer Science and Business Media LLC
Date: 19-12-2014
DOI: 10.1038/GT.2013.77
Abstract: Dendritic cells (DC) targeting vaccines require high efficiency for uptake, followed by DC activation and maturation. We used magnetic vectors comprising polyethylenimine (PEI)-coated superparamagnetic iron oxide nanoparticles, with hyaluronic acid (HA) of different molecular weights (<10 and 900 kDa) to reduce cytotoxicity and to facilitate endocytosis of particles into DCs via specific surface receptors. DNA encoding Plasmodium yoelii merozoite surface protein 1-19 and a plasmid encoding yellow fluorescent gene were added to the magnetic complexes with various % charge ratios of HA: PEI. The presence of magnetic fields significantly enhanced DC transfection and maturation. Vectors containing a high-molecular-weight HA with 100% charge ratio of HA: PEI yielded a better transfection efficiency than others. This phenomenon was attributed to their longer molecular chains and higher mucoadhesive properties aiding DNA condensation and stability. Insights gained should improve the design of more effective DNA vaccine delivery systems.
Publisher: Informa UK Limited
Date: 04-12-2023
Publisher: American Chemical Society (ACS)
Date: 18-06-2019
Abstract: Graphene-based laminar membranes open new avenues for water treatment in particular, reduced graphene oxide (rGO) membranes with high stability in aqueous solutions are gaining increased attention for desalination. However, the low water permeability of these membranes significantly limits their applications. In this study, the water permeability of thermally reduced GO membrane was increased by a factor of 26 times by creating in-plane nanopores with an average diameter of ∼3 nm and a high density of 2.89 × 10
Publisher: Elsevier BV
Date: 12-2012
Publisher: Elsevier
Date: 2017
Publisher: Elsevier BV
Date: 05-2023
Publisher: Elsevier BV
Date: 04-2015
Publisher: Elsevier BV
Date: 04-2016
DOI: 10.1016/J.COLSURFB.2016.01.012
Abstract: The dominant presence of fat at the surface of spray-dried milk powders has been widely reported in the literature and described as resulting in unfavourable powder properties. The mechanism(s) causing this phenomenon are yet to be clearly identified. A systematic investigation of the component distribution in atomized droplets and spray-dried particles consisting of model milk systems with different fat contents demonstrated that atomization strongly influences the final surface composition. Cryogenic flash-freezing of uniform droplets from a microfluidic jet nozzle directly after atomization helped to distinguish the influence of the atomization stage from the drying stage. It was confirmed that the overrepresentation of fat on the surface is independent of the atomization technique, including a pressure-swirl single-fluid spray nozzle and a pilot-scale rotary disk spray dryer commonly used in industry. It is proposed that during the atomization stage a disintegration mechanism along the oil-water interface of the fat globules causes the surface predominance of fat. X-ray photoelectron spectroscopic measurements detected the outermost fat layer and some adjacent protein present on both atomized droplets and spray-dried particles. Confocal laser scanning microscopy gave a qualitative insight into the protein and fat distribution throughout the cross-sections, and confirmed the presence of a fat film along the particle surface. The film remained on the surface in the subsequent drying stage, while protein accumulated underneath, driven by diffusion. The results demonstrated that atomization induces component segregation and fat-rich surfaces in spray-dried milk powders, and thus these cannot be prevented by adjusting the spray drying conditions.
Publisher: Elsevier BV
Date: 06-2012
Publisher: Elsevier BV
Date: 2012
Publisher: Elsevier BV
Date: 06-2021
Publisher: American Chemical Society (ACS)
Date: 12-04-2016
Publisher: Elsevier BV
Date: 06-2023
Publisher: Elsevier BV
Date: 05-2011
Publisher: Elsevier BV
Date: 2017
Publisher: Springer Science and Business Media LLC
Date: 12-04-2016
Publisher: Elsevier BV
Date: 03-2014
DOI: 10.1016/J.FOODCHEM.2013.09.087
Abstract: A study to compare the uptake, translocation, and distribution of selenium (Se) in soybean planted in natural seleniferous soil in Fengcheng city of China was conducted to clarify the relationship between the Se content levels of soybean proteins and their radical scavenging activity. The data showed that the total Se content in different parts of soybean plants varied with the growth periods. The selenoprotein (Se-SPI) content increased remarkably with the increase of Se content in seleniferous soils. The Se-SPI content obtained from the region with the highest Se level was almost 18 times higher than that of the control group, while antioxidant activities were about 4-fold compared to the control, suggesting that Se played a positive role in enhancing the antioxidant activity of Se-SPI. The increase in the Se level also led to changes in amino acids composition, but with nearly no effects on the subunit composition of soybean Se-SPI.
Publisher: Elsevier BV
Date: 2016
Publisher: Elsevier BV
Date: 10-2015
DOI: 10.1016/J.FOODRES.2015.07.045
Abstract: Reconstituted skim milk (RSM) is a reputed protective carrier for improving the survival ratio of lactic acid bacteria (LAB) after spray drying however the underlying mechanisms of the prominent protection remains unclear. In this study, the inactivation histories of two LAB strains during droplet drying with four carriers were experimentally determined, and the effects of droplet drying parameters on LAB inactivation were investigated. For the first time, the possible contribution of each RSM components to the maintenance of LAB viability during drying was discussed. Rapid inactivation of LAB cells only started at the later stage of drying, where RSM could maintain viability better upon both high droplet temperature and low moisture content than the other three carriers tested. Such protective effects was attributed to calcium and milk proteins rather than lactose. Upon the rapidly increasing droplet temperature at the later stage, calcium might enhance the heat resistance of LAB cells, whereas proteins might lead to a mild temperature variation rate which was beneficial to cell survival. LAB cells dried in the reconstituted whole milk showed the most advanced transition of rapid viability loss, with transition temperature at around 60°C, in contrast to 65-70°C in lactose and MRS carriers and 75°C in the RSM carrier. The detrimental effects could be due to the high level of milk fat content. The proposed effects of each RSM components on LAB viability would be useful for constructing more powerful protectants for production of active dry LAB cells via spray drying.
Publisher: Elsevier BV
Date: 11-2018
Publisher: Informa UK Limited
Date: 02-04-2015
Publisher: AIP Publishing
Date: 10-03-2014
DOI: 10.1063/1.4867751
Abstract: Magnetic nanoparticles with narrow size distributions have successfully been synthesized by an ultrasonic assisted co-precipitation method. The effects of particle size on magnetic properties, heat generation by AC fields, and the cell cytotoxicity were investigated for MgFe2O4 nanoparticles with mean diameters varying from 7 ± 0.5 nm to 29 ± 1 nm. The critical size for superparamagnetic to ferrimagnetic transition (DS→F) of MgFe2O4 was determined to be about 13 ± 0.5 nm at 300 K. The specific absorption rate (SAR) of MgFe2O4 nanoparticles was strongly size dependent it showed a maximum value of 19 W/g when the particle size was 10 ± 0.5 nm at which the Néel and Brownian relaxations are the major cause of heating. The SAR value was suppressed dramatically by 46% with increasing particle size from 10 ± 0.5 nm to 13 ± 0.5 nm, where Néel relaxation slows down and SAR results primarily from Brownian relaxation loss. A further reduction in SAR value was evident when the size was increased from 13 ± 0.5 nm to 16 ± 1 nm, where the superparamagnetic to ferromagnetic transition occurs. However, SAR showed a tendency to increase with particle size again above 16 ± 1 nm where hysteresis loss becomes the dominant mechanism of heat generation. The particle size dependence of SAR in the superparamagnetic region was well described by considering the effective relaxation time estimated based on a log-normal size distribution. The clear size dependence of SAR is attributable to the high degree of monodispersity of particles synthesized here. The high SAR value of water-based MgFe2O4 magnetic suspension combined with low cell cytotoxicity suggests a great potential of MgFe2O4 nanoparticles for magnetic hyperthermia therapy applications.
Publisher: American Chemical Society (ACS)
Date: 11-06-2009
DOI: 10.1021/JP902684G
Publisher: Elsevier BV
Date: 12-2020
Publisher: Hindawi Limited
Date: 2011
DOI: 10.1155/2011/267218
Abstract: Particle size and morphology are important properties of pharmaceutical particles. Preparation of microparticles with uniform particle size and morphology is necessary in order to systematically relate these properties to the release behavior and other functionalities such as drug encapsulation and dissolution. In this study, we successfully prepared monodisperse, nonagglomerated chitosan microparticles in a single step by a novel spray-drying technique. The control of particle size and morphology of spray-dried microparticles was investigated experimentally. Microparticles with larger particle size can be produced when chitosan precursor of higher concentration was used. Storage time of chitosan precursor, drying temperature, and addition of lactose were shown to be crucial parameters that affect the particle morphology. Appropriate choice of the drying temperature and precursor storage time permitted control of the particle morphology, ranging from nearly spherical to cap-shaped. Surface characteristics of the particles can be finely tuned by the amount of lactose added into the chitosan precursor.
Publisher: Elsevier BV
Date: 02-2021
Publisher: Elsevier BV
Date: 03-2019
DOI: 10.1016/J.JCIS.2018.11.004
Abstract: Adsorption and catalytic conversion of nitrophenols (NPs) over carbon-based materials have attracted wide interest. Batch adsorption and catalytic reduction of NPs have been widely reported, but less attention has been paid to flow systems, which require high particle size uniformity and superior active site accessibility. Herein, uniform mesoporous carbon hollow microspheres with their surfaces enriched by Au nanoparticles (denoted as Au@UMCHMs) are synthesized. The surface-enriched Au nanoparticle loading is promoted by the unique feature, that is, relatively dense external layers and mesoporous inner shells, of the carbon microspheres and the simple impregnation-reduction method. The Au@UMCHMs possess uniform sizes of ∼82 μm, small shell thickness of ∼5.8 μm, high specific surface area (∼1587 m
Publisher: Elsevier BV
Date: 11-2020
Publisher: Elsevier BV
Date: 06-2021
Publisher: Elsevier BV
Date: 04-2021
Publisher: Elsevier BV
Date: 12-2014
Publisher: Springer New York
Date: 2014
DOI: 10.1007/978-1-4939-0410-5_12
Abstract: The efficiency of delivery of DNA vaccines is often relatively low compared to protein vaccines. The use of superparamagnetic iron oxide nanoparticles (SPIONs) to deliver genes via magnetofection shows promise in improving the efficiency of gene delivery both in vitro and in vivo. In particular, the duration for gene transfection especially for in vitro application can be significantly reduced by magnetofection compared to the time required to achieve high gene transfection with standard protocols. SPIONs that have been rendered stable in physiological conditions can be used as both therapeutic and diagnostic agents due to their unique magnetic characteristics. Valuable features of iron oxide nanoparticles in bioapplications include a tight control over their size distribution, magnetic properties of these particles, and the ability to carry particular biomolecules to specific targets. The internalization and half-life of the particles within the body depend upon the method of synthesis. Numerous synthesis methods have been used to produce magnetic nanoparticles for bioapplications with different sizes and surface charges. The most common method for synthesizing nanometer-sized magnetite Fe3O4 particles in solution is by chemical coprecipitation of iron salts. The coprecipitation method is an effective technique for preparing a stable aqueous dispersions of iron oxide nanoparticles. We describe the production of Fe3O4-based SPIONs with high magnetization values (70 emu/g) under 15 kOe of the applied magnetic field at room temperature, with 0.01 emu/g remanence via a coprecipitation method in the presence of trisodium citrate as a stabilizer. Naked SPIONs often lack sufficient stability, hydrophilicity, and the capacity to be functionalized. In order to overcome these limitations, polycationic polymer was anchored on the surface of freshly prepared SPIONs by a direct electrostatic attraction between the negatively charged SPIONs (due to the presence of carboxylic groups) and the positively charged polymer. Polyethylenimine was chosen to modify the surface of SPIONs to assist the delivery of plasmid DNA into mammalian cells due to the polymer's extensive buffering capacity through the "proton sponge" effect.
Publisher: American Chemical Society (ACS)
Date: 30-12-2020
Abstract: High desalination efficiency in principle could be achieved by layer-by-layer graphene oxide (GO) membranes, which benefits from their entrance-functionalized channels assembled by edge-functionalized GO nanosheets. The effects of these edge functional groups on desalination, however, are not fully understood yet. To study the isolated influence of three typical edge functional groups, namely, carboxyl (-COOH), hydroxyl (-OH), and hydrogen (-H), molecular dynamics simulation was used in this work. The results revealed that the edge volumetric blockage effect, resulting in ion permeability at G-H > G-OH > G-COOH membranes, was the dominant mechanistic effect inside the GO membranes with 7 Å interlayer channels. The OH edge has the same effect as the H edge in NaCl/water selectivity because of a unique "ion pulling" effect. Moreover, the OH and H edge-functionalized membranes with 7 Å interlayer channels showed preferential Na
Publisher: Elsevier BV
Date: 07-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C1JM12524A
Publisher: Elsevier BV
Date: 11-2022
Publisher: American Dairy Science Association
Date: 09-2014
Abstract: Mixing surfactants with whole milk feed before spray drying could be a commercially favorable approach to produce instant whole milk powders in a single step. Pure whole milk powders obtained directly from spray drying often have a high surface fat coverage (up to 98%), rendering them less stable during storage and less wettable upon reconstitution. Dairy industries often coat these powders with lecithin, a food-grade surfactant, in a secondary fluidized-bed drying stage to produce instant powders. This study investigated the changes in wetting behavior on the surface of a whole milk particle caused by the addition of surfactants before drying. Fresh whole milk was mixed with 0.1% (wt/wt) Tween 80 or 1% (wt/wt) lecithin (total solids), and the wetting behavior of the shell formed by each s le was captured using a single-droplet drying device at intermediate drying stages as the shell was forming. The addition of surfactants improved shell wettability from the beginning of shell formation, producing more wettable milk particles after drying. The increase in surfactant loading by 10 times reduced the wetting time from around 30s to <5s. At the same loading of 1% (wt/wt total solids), milk particles with Tween 80 were much more wettable than those with lecithin ( 30s). We proposed that Tween 80 could adsorb at the oil-water interface of fat globules, making the surface fat more wettable, whereas lecithin tends to combine with milk proteins to form a complex, which then competes for the air-water surface with fat globules. Spray-drying experiments confirmed the greatly improved wettability of whole milk powders by the addition of either 0.1% (wt/wt) Tween 80 or 1% (wt/wt) lecithin wetting time was reduced from 35±4s to <15s. To the best of our knowledge, this is the first time that a dynamic droplet drying system has been used to elucidate the complex interactions between ionic or nonionic surfactants and milk components (both proteins and fat), as well as the resultant effect on the development of milk particle functionality during drying.
Publisher: Elsevier BV
Date: 06-2012
Publisher: Elsevier BV
Date: 10-2012
DOI: 10.1016/J.FOODCHEM.2012.03.033
Abstract: The effects of various proteases on the formation and characteristics of rice dreg protein hydrolysates (RDPHs) were investigated. Enzymatic hydrolysis of often under-utilised rice dreg protein (RDP) with different enzymes studied here was found to significantly improve protein content and solubility. RDPHs prepared by alkaline protease showed better protein recovery, producing higher protein content with much smaller peptides, while hydrolysates generated by Protamex showed the highest antioxidant activities with more than 80% solubility over a wide pH range. The results indicated that the type of protease greatly influenced the molecular weight and amino acid residue composition of RDPH. The enzyme type also determined the functional properties and antioxidant activity of the recovered proteins. It was found that an optimum allocation of alkaline protease in addition to the Neutrase enzyme could be an appropriate strategy to produce RDPH with desirable functionalities, antioxidant properties, and low salt content.
Publisher: Elsevier BV
Date: 07-2015
Publisher: American Chemical Society (ACS)
Date: 06-09-2018
DOI: 10.1021/ACS.BIOCONJCHEM.7B00455
Abstract: The field of medical diagnostics and therapeutics is being revolutionized by nanotechnology, from targeted drug delivery to cancer immunotherapy. Inorganic nanoparticles are widely used, albeit problems with agglutination, cytotoxicity, free radical generation, and instability in some biological environments limits their utility. Conjugation of biomolecules such as peptides to the surface of nanoparticles can mitigate such problems, as well as confer specialized theranostic (therapeutic and/or diagnostic) properties, useful across biomedical applications such as vaccines, drug delivery, and in vivo imaging. Coating with amino acids, rather than peptides, offers further a highly cost-effective approach (due to their ease of purification and availability), but is currently an underutilized way to decrease toxicity and enhance stability. Amino acid molecules are small (<200 Da) and have both positive and negative charge groups (zwitterionic) facilitating charge-specific molecule binding. Additionally, amino acids exert by themselves some useful biological functions, with antibacterial and viability enhancing properties (for eukaryotic cells). Overall particle size, nanoparticle core, and the specific amino acid used to functionalize their surface influence their biodistribution, and their effects on host immunity. In this review, we provide for the first time an overview of this emerging field, and identify gaps in knowledge for future research.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9GC03354H
Abstract: Waste recycling-Green chemistry technologies for the preparation of fully environment-friendly rice protein films with improved accessibility have been developed.
Publisher: Elsevier BV
Date: 2020
Publisher: Elsevier BV
Date: 03-2018
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C0SM01371D
Publisher: Elsevier BV
Date: 02-2013
Publisher: MDPI AG
Date: 10-02-2017
DOI: 10.3390/NANO7020030
Publisher: Elsevier BV
Date: 08-2017
Publisher: Elsevier BV
Date: 08-2017
Publisher: Elsevier BV
Date: 2016
Publisher: AIP Publishing
Date: 20-10-2014
DOI: 10.1063/1.4900557
Abstract: While materials with a 1st order Curie transition (TC) are known for the magnetic cooling effect due to the reversibility of their large entropy change, they also have a great potential as a candidate material for induction heating where a large loss power is required under a limited alternating magnetic field. We have carried out a proof-of-concept study on the induction heating effect in 1st order ferromagnetic materials where the temperature is self-regulated at TC. LaFe11.57Si1.43H1.75, a well-known magnetocaloric material, was employed in this study because TC of this compound (319 K) resides in the ideal temperature range for hyperthermia treatment of cancerous cells. It is found that the hysteresis loss of LaFe11.57Si1.43H1.75 increases dramatically near TC due to the magnetic phase coexistence associated with the 1st order magnetic transition. The spontaneous magnetization (Ms) shows a very abrupt decrease from 110 Am2kg−1 at 316 K to zero at 319 K. This large Ms immediately below TC along with the enhanced irreversibility of the hysteresis curve result in a specific absorption rate as large as 0.5 kWg−1 under a field of 8.8 kAm−1 at 279 kHz. This value is nearly an order of magnitude larger than that observed under the same condition for conventional iron oxide-based materials. Moreover, the large heating effect is self-regulated at the 1st order TC (319 K). This proof-of-concept study shows that the extraordinary heating effect near the 1st order Curie point opens up a novel alloy design strategy for large, self-regulated induction heating.
Publisher: Wiley
Date: 10-05-2020
Publisher: Informa UK Limited
Date: 26-10-2013
Publisher: Elsevier BV
Date: 03-2012
Publisher: American Chemical Society (ACS)
Date: 14-05-2020
DOI: 10.1021/JACS.0C03554
Publisher: Springer Science and Business Media LLC
Date: 12-06-2013
DOI: 10.1038/NATURE12221
Abstract: Coccolithophores have influenced the global climate for over 200 million years. These marine phytoplankton can account for 20 per cent of total carbon fixation in some systems. They form blooms that can occupy hundreds of thousands of square kilometres and are distinguished by their elegantly sculpted calcium carbonate exoskeletons (coccoliths), rendering them visible from space. Although coccolithophores export carbon in the form of organic matter and calcite to the sea floor, they also release CO2 in the calcification process. Hence, they have a complex influence on the carbon cycle, driving either CO2 production or uptake, sequestration and export to the deep ocean. Here we report the first haptophyte reference genome, from the coccolithophore Emiliania huxleyi strain CCMP1516, and sequences from 13 additional isolates. Our analyses reveal a pan genome (core genes plus genes distributed variably between strains) probably supported by an atypical complement of repetitive sequence in the genome. Comparisons across strains demonstrate that E. huxleyi, which has long been considered a single species, harbours extensive genome variability reflected in different metabolic repertoires. Genome variability within this species complex seems to underpin its capacity both to thrive in habitats ranging from the equator to the subarctic and to form large-scale episodic blooms under a wide variety of environmental conditions.
Publisher: Elsevier BV
Date: 09-2022
Publisher: Elsevier BV
Date: 2020
Publisher: Elsevier BV
Date: 08-2011
Publisher: American Chemical Society (ACS)
Date: 29-05-2014
DOI: 10.1021/EF500618R
Publisher: Royal Society of Chemistry (RSC)
Date: 2007
DOI: 10.1039/B711705A
Publisher: Wiley
Date: 28-12-2017
DOI: 10.1111/IJFS.13717
Publisher: Elsevier BV
Date: 10-2015
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 07-2013
Publisher: American Chemical Society (ACS)
Date: 20-03-2020
Publisher: Elsevier BV
Date: 08-2016
Publisher: Elsevier BV
Date: 08-2017
Publisher: Springer Science and Business Media LLC
Date: 19-04-2012
Publisher: Elsevier BV
Date: 10-2013
Publisher: Elsevier BV
Date: 03-2021
Publisher: Elsevier BV
Date: 12-2013
Publisher: Elsevier BV
Date: 2018
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8NR08418A
Abstract: CoS 2 –MoS 2 –MoO 2 (CoMoOS) can synergistically catalyze alkaline HER with excellent performance, where MoO 2 promotes water dissociation and CoS 2 –MoS 2 nano-flakes facilitate the hydrogen adsorption.
Publisher: American Chemical Society (ACS)
Date: 13-10-2015
Publisher: Elsevier BV
Date: 03-2014
Publisher: Informa UK Limited
Date: 28-08-2017
Publisher: Informa UK Limited
Date: 13-04-2021
DOI: 10.1080/10408398.2021.1910139
Abstract: Plant-derived protein research has gained attention in recent years due to the rise of health concerns, allergenicity, trends toward vegan diet, food safety, and sustainability but the lower techno-functional attributes of plant proteins compared to those of animals still remain a challenge for their utilization. Maillard conjugation is a protein side-chain modification reaction which is spontaneous, and do not require additional chemical additive to initiate the reaction. The glycoconjugates formed during the reaction significantly improves the thermal stability and pH sensitivity of proteins. The modification of plant-derived protein using Maillard conjugation requires a comprehensive understanding of the influence of process conditions on the conjugation process. These factors can be used to establish a correlation with different functional and bioactive characteristics, to potentially adapt this approach for selective functionality enhancement and nutraceutical development. This review covers recent advances in plant-derived protein modification using Maillard conjugation, including different pretreatments to modify the functionality and bioactivity of plant proteins and their potential uses in practice. An overview of different properties of conjugates and MRPs, including food safety aspects, is given.
Publisher: American Chemical Society (ACS)
Date: 04-09-2013
DOI: 10.1021/IE4000807
Publisher: Elsevier BV
Date: 12-2010
Publisher: Elsevier BV
Date: 04-2019
DOI: 10.1016/J.IJPHARM.2018.12.045
Abstract: The surface structure of crystalline particles affects the functionality of the particles in drug delivery. Prediction of the final structure of particles that crystallize easily within the spray drying process is of interests for many applications. A theoretical framework was developed for the prediction of crystal structure precipitating on the surface of the particle. This model was based on the dimensionless Damkohler number (Da), to be an indicator of final particle morphology. Timescales of evaporation and reaction were required for calculation of the Damkohler number. The modified evaporation time scale was estimated based on the time that is available for the crystal to precipitate after supersaturation. The reaction time scale was estimated based on the time scale for induction time. Mannitol was produced under different processing conditions in order to validate the theoretical model. Results showed for the high Damkohler numbers, the surface structure of the particle was rough, while smaller Damkohler numbers led to relatively smooth particle surfaces. Additionally, although the beta polymorph was dominant in all of the experiments, alpha polymorph was precipitated in the experiments with a large Damkohler number. The theoretical framework developed will be a useful predictive tool to guide the manipulation of particle crystallization in spray dryers.
Publisher: Elsevier BV
Date: 11-2019
DOI: 10.1016/J.JCIS.2019.08.084
Abstract: The fast and scalable spray-drying-assisted evaporation-induced self-assembly (EISA) synthesis of hierarchically porous SBA-15-type silica microparticles from a water-based system is demonstrated. The SBA-15-type silica microparticles has bowl-like shapes, uniform micro-sizes (∼90 µm), large ordered mesopores (∼9.5 nm), hierarchical meso-/macropores (20-100 nm) and open surfaces. In the synthesis, soft- and hard-templating approaches are combined in a single rapid drying process with a non-ionic tri-block copolymer (F127) and a water-insoluble polymer colloid (Eudragit RS, 120 nm) as the co-templates. The RS polymer colloid plays three important roles. First, the RS nanoparticles can be partially dissolved by in-situ generated ethanol to form RS polymer chains. The RS chains swell and modulate the hydrophilic-hydrophobic balance of F127 micelles to allow the formation of an ordered mesostructure with large mesopore sizes. Without RS, only worm-like mesostructure with much smaller mesopore sizes can be formed. Second, part of the RS nanoparticles plays a role in templating the hierarchical pores distributed throughout the microparticles. Third, part of the RS polymer forms surface "skins" and "bumps", which can be removed by calcination to enable a more open surface structure to overcome the low pore accessibility issue of spray-dried porous microparticles. The obtained materials have high surface areas (315-510 m
Publisher: Elsevier BV
Date: 10-2012
Publisher: American Chemical Society (ACS)
Date: 12-12-2016
DOI: 10.1021/JACS.6B10782
Abstract: High-power sodium-ion batteries (SIBs) with long-term cycling attract increasing attention for large-scale energy storage. However, traditional SIBs toward practical applications still suffer from low rate capability and poor cycle induced by pulverization and amorphorization of anodes at high rate (over 5 C) during the fast ion insertion/extraction process. The present work demonstrates a robust strategy for a variety of (Sb-C, Bi-C, Sn-C, Ge-C, Sb-Bi-C) freestanding metal-carbon framework thin films via a space-confined superassembly (SCSA) strategy. The sodium-ion battery employing the Sb-C framework exhibits an unprecedented performance with a high specific capacity of 246 mAh g
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Cordelia Selomulya.