ORCID Profile
0000-0001-9016-3847
Current Organisations
Assistance Publique Hôpitaux de Paris
,
Universite de Paris
,
Umr 261 MERIT
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Publisher: Oxford University Press (OUP)
Date: 25-10-2017
DOI: 10.1093/CID/CIX913
Abstract: Prosthetic valve endocarditis caused by Candida spp. (PVE-C) is rare and devastating, with international guidelines based on expert recommendations supporting the combination of surgery and subsequent azole treatment. We retrospectively analyzed PVE-C cases collected in Spain and France between 2001 and 2015, with a focus on management and outcome. Forty-six cases were followed up for a median of 9 months. Twenty-two patients (48%) had a history of endocarditis, 30 cases (65%) were nosocomial or healthcare related, and 9 (20%) patients were intravenous drug users. "Induction" therapy consisted mainly of liposomal hotericin B (L-amB)-based (n = 21) or echinocandin-based therapy (n = 13). Overall, 19 patients (41%) were operated on. Patients <66 years old and without cardiac failure were more likely to undergo cardiac surgery (adjusted odds ratios [aORs], 6.80 [95% confidence interval [CI], 1.59-29.13] and 10.92 [1.15-104.06], respectively). Surgery was not associated with better survival rates at 6 months. Patients who received L-amB alone had a better 6-month survival rate than those who received an echinocandin alone (aOR, 13.52 95% CI, 1.03-838.10). "Maintenance" fluconazole therapy, prescribed in 21 patients for a median duration of 13 months (range, 2-84 months), led to minor adverse effects. L-amB induction treatment improves survival in patients with PVE-C. Medical treatment followed by long-term maintenance fluconazole may be the best treatment option for frail patients.
Publisher: American Society of Tropical Medicine and Hygiene
Date: 10-2014
Publisher: Public Library of Science (PLoS)
Date: 13-05-2009
Publisher: Public Library of Science (PLoS)
Date: 09-03-2020
Publisher: Springer Science and Business Media LLC
Date: 25-10-2007
Abstract: Malaria diagnosis is vital to efficient control programmes and the recent advent of malaria rapid diagnostic tests (RDTs) provides a reliable and simple diagnostic method. However a characterization of the efficiency of these tests and the proteins they detect is needed to maximize RDT sensitivity. Plasmodial lactate dehydrogenase ( pLDH ) gene of wild isolates of the four human species of Plasmodium from a variety of malaria endemic settings were sequenced and analysed. No variation in nucleotide was found within Plasmodium falciparum , synonymous mutations were found for Plasmodium malariae and Plasmodium. vivax and three different types of amino acid sequence were found for Plasmodium ovale . Conserved and variable regions were identified within each species. The results indicate that antigen variability is unlikely to explain variability in performance of RDTs detecting pLDH from cases of P. falciparum, P. vivax or P. malariae malaria, but may contribute to poor detection of P. ovale .
Publisher: Massachusetts Medical Society
Date: 23-06-2016
No related grants have been discovered for houze sandrine.