ORCID Profile
0000-0001-5822-8401
Current Organisation
University of Adelaide
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Publisher: The Optical Society
Date: 27-07-2016
DOI: 10.1364/OE.24.017860
Publisher: The Optical Society
Date: 27-04-2017
DOI: 10.1364/OL.42.001812
Publisher: SPIE
Date: 17-10-2012
DOI: 10.1117/12.970611
Publisher: American Chemical Society (ACS)
Date: 13-05-2016
Abstract: Sensing platforms that allow rapid and efficient detection of metal ions would have applications in disease diagnosis and study, as well as environmental sensing. Here, we report the first microstructured optical fiber-based biosensor for the reversible and nanoliter-scale measurement of metal ions. Specifically, a photoswitchable spiropyran Zn(2+) sensor is incorporated within the microenvironment of a liposome attached to microstructured optical fibers (exposed-core and suspended-core microstructured optical fibers). Both fiber-based platforms retains high selectivity of ion binding associated with a small molecule sensor, while also allowing nanoliter volume s ling and on/off switching. We have demonstrated that multiple measurements can be made on a single s le without the need to change the sensor. The ability of the new sensing platform to sense Zn(2+) in pleural lavage and nasopharynx of mice was compared to that of established ion sensing methodologies such as inductively coupled plasma mass spectrometry (ICP-MS) and a commercially available fluorophore (Fluozin-3), where the optical-fiber-based sensor provides a significant advantage in that it allows the use of nanoliter (nL) s ling when compared to ICP-MS (mL) and FluoZin-3 (μL). This work paves the way to a generic approach for developing surface-based ion sensors using a range of sensor molecules, which can be attached to a surface without the need for its chemical modification and presents an opportunity for the development of new and highly specific ion sensors for real time sensing applications.
Publisher: AIP Publishing
Date: 10-09-2018
DOI: 10.1063/1.5040861
Abstract: The probing of physiological processes in living organisms is a grand challenge that requires bespoke analytical tools. Optical fiber probes offer a minimally invasive approach to report physiological signals from specific locations inside the body. This perspective article discusses a wide range of such fiber probes developed at the Australian Research Council Centre of Excellence for Nanoscale BioPhotonics. Our fiber platforms use a range of sensing modalities, including embedded nanodiamonds for magnetometry, interferometric fiber cavities for refractive index sensing, and tailored metal coatings for surface plasmon resonance sensing. Other fiber probes exploit molecularly sensitive Raman scattering or fluorescence where optical fibers have been combined with chemical and immunosensors. Fiber imaging probes based on interferometry and computational imaging are also discussed as emerging in vivo diagnostic devices. We provide ex les to illustrate how the convergence of multiple scientific disciplines generates opportunities for the fiber probes to address key challenges in real-time in vivo diagnostics. These future fiber probes will enable the asking and answering of scientific questions that were never possible before.
Publisher: SPIE
Date: 20-04-2016
DOI: 10.1117/12.2219496
Publisher: American Physical Society (APS)
Date: 22-07-2015
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3RA40321A
Publisher: OSA
Date: 2019
Publisher: Elsevier BV
Date: 11-2017
Publisher: The Optical Society
Date: 02-12-2014
DOI: 10.1364/OME.4.000029
Publisher: The Optical Society
Date: 03-07-2014
DOI: 10.1364/OME.4.001515
Publisher: The Optical Society
Date: 02-10-2012
DOI: 10.1364/OME.2.001538
Publisher: Wiley
Date: 21-07-2015
DOI: 10.1111/IJAG.12128
Publisher: SPIE
Date: 03-05-2013
DOI: 10.1117/12.2016510
Publisher: IEEE
Date: 07-2017
Publisher: MDPI AG
Date: 17-04-2019
DOI: 10.3390/S19081829
Abstract: One of the biggest challenges associated with exposed core glass optical fiber-based sensing is the availability of techniques that can be used to generate reproducible, homogeneous and stable surface coating. We report a one step, solvent free method for surface functionalization of exposed core glass optical fiber that allows achieving binding of fluorophore of choice for metal ion sensing. The plasma polymerization-based method yielded a homogeneous, reproducible and stable coating, enabling high sensitivity aluminium ion sensing. The sensing platform reported in this manuscript is versatile and can be used to bind different sensing molecules opening new avenues for optical fiber-based sensing.
Publisher: SPIE
Date: 20-02-2014
DOI: 10.1117/12.2039336
Publisher: SPIE
Date: 02-06-2014
DOI: 10.1117/12.2059481
Publisher: American Chemical Society (ACS)
Date: 15-11-2018
Abstract: Many biological processes are driven by the interaction of a host with a guest molecule. We show such interactions can be modulated by carefully defining the local molecular environment to give a specific chemical outcome. Particularly, the selectivity of a host toward two different ions (Ca
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D2CP03858G
Abstract: The search for quantum behaviour within a BODIPY light-harvesting complex reveals coherent oscillations at 100 cm −1 and 600 cm −1 .
Publisher: The Optical Society
Date: 18-11-2014
DOI: 10.1364/OE.22.029493
Publisher: Trans Tech Publications, Ltd.
Date: 06-2013
DOI: 10.4028/WWW.SCIENTIFIC.NET/KEM.558.522
Abstract: This paper summarises recent work conducted on the development of exposed core microstructured optical fibres for distributed corrosion sensing. Most recently, exposed-core fibres have been fabricated in silica glass, which is known to be reliable under a range of processing and service environments. We characterise the stability of these new silica fibres when exposed to some typical sensing and storage environments. We show the background loss to be the best achieved to date for exposed-core fibres, while the transmission properties are up to ~2 orders of magnitude better than for the previously reported exposed-core fibres produced in soft glass. This provides a more robust fibre platform for corrosion sensing conditions and opens up new opportunities for distributed optical fibre sensors requiring long-term application in harsh environments.
Publisher: American Chemical Society (ACS)
Date: 15-01-2020
DOI: 10.1021/ACSSENSORS.9B02308
Abstract: Extracellular Ca
Publisher: Wiley
Date: 18-06-2020
DOI: 10.1002/TPG2.20028
No related grants have been discovered for Roman Kostecki.