XIAOGANG LIU

Volumetric Nanocrystal Lattice Reconstruction through Dynamic Metal Complex Docking

Publisher: American Chemical Society (ACS)

Date: 20-06-2023

DOI: 10.1021/ACS.NANOLETT.3C01621

Photolithographic Fabrication of Upconversion Barcodes for Multiplexed Molecular Detection

Publisher: Wiley

Date: 22-09-2020

DOI: 10.1002/ADOM.202001168

Subwavelength imaging through ion-beam-induced upconversion

Publisher: Springer Science and Business Media LLC

Date: 12-11-2015

DOI: 10.1038/NCOMMS9832

Abstract: The combination of an optical microscope and a luminescent probe plays a pivotal role in biological imaging because it allows for probing subcellular structures. However, the optical resolutions are largely constrained by Abbe’s diffraction limit, and the common dye probes often suffer from photobleaching. Here we present a new method for subwavelength imaging by combining lanthanide-doped upconversion nanocrystals with the ionoluminescence imaging technique. We experimentally observed that the ion beam can be used as a new form of excitation source to induce photon upconversion in lanthanide-doped nanocrystals. This approach enables luminescence imaging and simultaneous mapping of cellular structures with a spatial resolution of sub-30 nm.

Nanoscale optical writing through upconversion resonance energy transfer

Publisher: American Association for the Advancement of Science (AAAS)

Date: 26-02-2021

DOI: 10.1126/SCIADV.ABE2209

Abstract: Resonance energy transfer from upconversion nanoparticles induces the reduction in graphene oxide for nanoscale optical writing.

Solution Epitaxy of Halide Perovskite Thin Single Crystals for Stable Transistors

Publisher: American Chemical Society (ACS)

Date: 27-07-2021

DOI: 10.1021/ACSAMI.1C08800

Three-dimensional controlled growth of monodisperse sub-50 nm heterogeneous nanocrystals

Publisher: Springer Science and Business Media LLC

Date: 08-01-2016

DOI: 10.1038/NCOMMS10254

Abstract: The ultimate frontier in nanomaterials engineering is to realize their composition control with atomic scale precision to enable fabrication of nanoparticles with desirable size, shape and surface properties. Such control becomes even more useful when growing hybrid nanocrystals designed to integrate multiple functionalities. Here we report achieving such degree of control in a family of rare-earth-doped nanomaterials. We experimentally verify the co-existence and different roles of oleate anions (OA − ) and molecules (OAH) in the crystal formation. We identify that the control over the ratio of OA − to OAH can be used to directionally inhibit, promote or etch the crystallographic facets of the nanoparticles. This control enables selective grafting of shells with complex morphologies grown over nanocrystal cores, thus allowing the fabrication of a erse library of monodisperse sub-50 nm nanoparticles. With such programmable additive and subtractive engineering a variety of three-dimensional shapes can be implemented using a bottom–up scalable approach.

Advances in highly doped upconversion nanoparticles

Publisher: Springer Science and Business Media LLC

Date: 20-06-2018

DOI: 10.1038/S41467-018-04813-5

Abstract: Lanthanide-doped upconversion nanoparticles (UCNPs) are capable of converting near-infra-red excitation into visible and ultraviolet emission. Their unique optical properties have advanced a broad range of applications, such as fluorescent microscopy, deep-tissue bioimaging, nanomedicine, optogenetics, security labelling and volumetric display. However, the constraint of concentration quenching on upconversion luminescence has h ered the nanoscience community to develop bright UCNPs with a large number of dopants. This review surveys recent advances in developing highly doped UCNPs, highlights the strategies that bypass the concentration quenching effect, and discusses new optical properties as well as emerging applications enabled by these nanoparticles.

Controlling upconversion nanocrystals for emerging applications

Publisher: Springer Science and Business Media LLC

Date: 11-2015

DOI: 10.1038/NNANO.2015.251

Abstract: Lanthanide-doped upconversion nanocrystals enable anti-Stokes emission with pump intensities several orders of magnitude lower than required by conventional nonlinear optical techniques. Their exceptional properties, namely large anti-Stokes shifts, sharp emission spectra and long excited-state lifetimes, have led to a ersity of applications. Here, we review upconversion nanocrystals from the perspective of fundamental concepts and examine the technical challenges in relation to emission colour tuning and luminescence enhancement. In particular, we highlight the advances in functionalization strategies that enable the broad utility of upconversion nanocrystals for multimodal imaging, cancer therapy, volumetric displays and photonics.

A 1.3-micrometre-thick elastic conductor for seamless on-skin and implantable sensors

Publisher: Springer Science and Business Media LLC

Date: 21-11-2022

DOI: 10.1038/S41928-022-00868-X

Continuous-wave near-infrared stimulated-emission depletion microscopy using downshifting lanthanide nanoparticles

Publisher: Springer Science and Business Media LLC

Date: 14-06-2021

DOI: 10.1038/S41565-021-00927-Y

All-inorganic perovskite nanocrystal scintillators

Publisher: Springer Science and Business Media LLC

Date: 27-08-2018

DOI: 10.1038/S41586-018-0451-1

Abstract: The rising demand for radiation detection materials in many applications has led to extensive research on scintillators

Solution-Processed Mixed-Dimensional Hybrid Perovskite/Carbon Nanotube Electronics

Publisher: American Chemical Society (ACS)

Date: 02-03-2020

DOI: 10.1021/ACSNANO.9B07888

Hypoxia deactivates epigenetic feedbacks via enzyme-derived clicking proteolysis-targeting chimeras

Publisher: American Association for the Advancement of Science (AAAS)

Date: 14-12-2022

DOI: 10.1126/SCIADV.ABQ2216

Abstract: Epigenetic mediation through bromodomain and extraterminal (BET) proteins have progressively translated protein imbalance into effective cancer treatment. Perturbation of druggable BET proteins through proteolysis-targeting chimeras (PROTACs) has recently contributed to the discovery of effective therapeutics. Unfortunately, precise and microenvironment-activatable BET protein degradation content with promising tumor selectivity and pharmacological suitability remains elusive. Here, we present an enzyme-derived clicking PROTACs (ENCTACs) capable of orthogonally cross-linking two disparate small-molecule warhead ligands that recognize BET bromodomain-containing protein 4 (BRD4) protein and E3 ligase within tumors only upon hypoxia-induced activation of nitroreductase enzyme. This localized formation of heterobifunctional degraders promotes specific down-regulation of BRD4, which subsequently alters expression of epigenetic targets and, therefore, allows precise modulation of hypoxic signaling in live cells, zebrafish, and living mice with solid tumors. Our activation-feedback system demonstrates compelling superiorities and may enable the PROTAC technology with more flexible practicality and druggable potency for precision medicine in the near future.

Northwestern University

Location: United States of America

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National University Of Singapore

Location: Singapore

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Discovery Projects - Grant ID: DP170101775

Start Date: 2017

End Date: 05-2019

Amount: $391,000.00

Funder: Australian Research Council