ORCID Profile
0000-0003-2767-0349
Current Organisations
Institut Pasteur de Madagascar
,
Universite de Toliara
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Publications
Field-based evidence for the linkage of pfcrt and pfdhfr drug-resistant malaria genotypes and clinical profiles of severe malaria in Niger
Publisher: Elsevier BV
Date: 04-2007
DOI: 10.1016/J.MICINF.2007.02.003
Abstract: Drug resistance has been shown to increase malaria mortality and morbidity in both community- and hospital-based studies. We investigated the association between two Plasmodium falciparum drug resistance-related molecular markers and clinical profiles of severe malaria in children hospitalised in Niger. PCR-RFLP analysis showed that the codon 108 mutation of the pfdhfr gene was positively linked to severe malarial anaemia. These findings are consistent with persistent parasite infection leading to unbalanced anaemia in young children. No significant relationship was found between the molecular markers and hypoglycaemia or hyperparasitaemia. Conversely, the pfcrt T76 mutation was found to be negatively associated with cerebral malaria and neurological symptoms, such as convulsions and coma. These results have implications for the strain-specific virulence hypothesis and for parasite fitness and evolution. Our findings are discussed in regard to the local malaria transmission level.
Mapping of aPlasmodium falciparum pfcrtK76T Mutation: A Useful Strategy for Controlling Chloroquine Resistance in Madagascar
Publisher: Oxford University Press (OUP)
Date: 03-2002
DOI: 10.1086/339000
Longitudinal survey of malaria morbidity over 10 years in Saharevo (Madagascar): further lessons for strengthening malaria control
Publisher: Springer Science and Business Media LLC
Date: 06-08-2009
Abstract: Madagascar has been known for having bio-geo-ecological ersity which is reflected by a complex malaria epidemiology ranging from hyperendemic to malaria-free areas. Malaria-related attacks and infection are frequently recorded both in children and adults living in areas of low malaria transmission. To integrate this variability in the national malaria control policy, extensive epidemiological studies are required to up-date previous records and adjust strategies. A longitudinal malaria survey was conducted from July 1996 to June 2005 among an average cohort of 214 villagers in Saharevo, located at 900 m above the sea. Saharevo is a typical eastern foothill site at the junction between a costal wet tropical area (equatorial malaria pattern) and a drier high-altitude area (low malaria transmission). Passive and active malaria detection revealed that malaria transmission in Saharevo follows an abrupt seasonal variation. Interestingly, malaria was confirmed in 45% (1,271/2,794) of malaria-presumed fevers seen at the health centre. All four Plasmodia that infect humans were also found: Plasmodium falciparum Plasmodium vivax , Plasmodium malariae and Plasmodium ovale . Half of the malaria-presumed fevers could be confirmed over the season with the highest malaria transmission level, although less than a quarter in lower transmission time, highlighting the importance of diagnosis prior to treatment intake. P. falciparum malaria has been predominant (98%). The high prevalence of P. falciparum malaria affects more particularly under 10 years old children in both symptomatic and asymptomatic contexts. Children between two and four years of age experienced an average of 2.6 malaria attacks with P. falciparum per annum. Moreover, estimated incidence of P. falciparum malaria tends to show that half of the attacks (15 attacks) risk to occur during the first 10 years of life for a 60-year-old adult who would have experienced 32 malaria attacks. The incidence of malaria decreased slightly with age but remained important among children and adults in Saharevo. These results support that a premunition against malaria is slowly acquired until adolescence. However, this claims for a weak premunition among villagers in Saharevo and by extension in the whole eastern foothill area of Madagascar. While the Malagasy government turns towards malaria elimination plans nowadays, choices and expectations to up-date and adapt malaria control strategies in the foothill areas are discussed in this paper.
Invasion of Africa by a single pfcrt allele of South East Asian type
Publisher: Springer Science and Business Media LLC
Date: 26-04-2006
Genomic analysis of local variation and recent evolution in Plasmodium vivax
Publisher: Springer Science and Business Media LLC
Date: 27-06-2016
DOI: 10.1038/NG.3599
African apes as reservoirs of Plasmodium falciparum and the origin and diversification of the Laverania subgenus.
Publisher: Proceedings of the National Academy of Sciences
Date: 24-05-2010
Abstract: We investigated two mitochondrial genes ( cytb and cox1 ), one plastid gene ( tufA ), and one nuclear gene ( ldh ) in blood s les from 12 chimpanzees and two gorillas from Cameroon and one lemur from Madagascar. One gorilla s le is related to Plasmodium falciparum , thus confirming the recently reported presence in gorillas of this parasite. The second gorilla s le is more similar to the recently defined Plasmodium gaboni than to the P. falciparum–Plasmodium reichenowi clade, but distinct from both. Two chimpanzee s les are P. falciparum . A third s le is P. reichenowi and two others are P. gaboni . The other chimpanzee s les are different from those in the ape clade: two are Plasmodium ovale , and one is Plasmodium malariae . That is, we have found three human Plasmodium parasites in chimpanzees. Four chimpanzee s les were mixed: one species was P. reichenowi the other species was P. gaboni in three s les and P. ovale in the fourth s le. The lemur s le, provisionally named Plasmodium malagasi , is a sister lineage to the large cluster of primate parasites that does not include P. falciparum or ape parasites, suggesting that the falciparum + ape parasite cluster ( Laverania clade) may have evolved from a parasite present in hosts not ancestral to the primates. If malignant malaria were eradicated from human populations, chimpanzees, in addition to gorillas, might serve as a reservoir for P. falciparum .
Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments—a WWARN individual patient data meta-analysis
Publisher: Springer Science and Business Media LLC
Date: 17-01-2019
First evidence of pfcrt mutant Plasmodium falciparum in Madagascar
Publisher: Oxford University Press (OUP)
Date: 09-2006
A Worldwide Map ofPlasmodium falciparumK13-Propeller Polymorphisms
Publisher: Massachusetts Medical Society
Date: 23-06-2016
Atelier paludisme: an international malaria training course held in Madagascar.
Publisher: Springer Science and Business Media LLC
Date: 09-05-2008
Abstract: The Atelier Paludisme (Malaria Workshop) is an international training course organized by the Institut Pasteur de Madagascar, which has been held annually for the past five years. The course was designed for both young and experienced researchers, as well as for healthcare professionals, mostly from malaria-endemic countries. Its objective is to provide participants with a broad knowledge of all features of malaria, to improve their skills in project management, to break geographical isolation by using the Internet as a source of documentary information. This six-week course makes use of concepts of andragogy and problem-based learning, i.e. a relationship between participants and tutors, which promotes a process of exchange rather than the simple transmission of knowledge, where participants have to search actively for information. This approach to training, combined with the wide background and experience of those involved, creates positive dynamics and enables participants to acquire new skills, develop their critical and analytical abilities. This paper describes the course and the lessons learned from its evaluation.
Related Organisations
Related Funding Activities
No related grants have been discovered for Milijaona Randrianarivelojosia.