ORCID Profile
0000-0001-8567-7042
Current Organisations
SA Health
,
University of Adelaide
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Wiley
Date: 20-02-2020
Publisher: Elsevier BV
Date: 02-2018
DOI: 10.1016/J.BIOMATERIALS.2017.11.017
Abstract: Dendritic cells (DC) are the most potent antigen-presenting cells and are fundamental for the establishment of transplant tolerance. The Dendritic Cell-Specific Intracellular adhesion molecule-3-Grabbing Non-integrin (DC-SIGN CD209) receptor provides a target for dendritic cell therapy. Biodegradable and high-surface area porous silicon (pSi) nanoparticles displaying anti-DC-SIGN antibodies and loaded with the immunosuppressant rapamycin (Sirolimus) serve as a fit-for-purpose platform to target and modify DC. Here, we describe the fabrication of rapamycin-loaded DC-SIGN displaying pSi nanoparticles, the uptake efficiency into DC and the extent of nanoparticle-induced modulation of phenotype and function. DC-SIGN antibody displaying pSi nanoparticles favourably targeted and were phagocytosed by monocyte-derived and myeloid DC in whole human blood in a time- and dose-dependent manner. DC preconditioning with rapamycin-loaded nanoparticles, resulted in a maturation resistant phenotype and significantly suppressed allogeneic T-cell proliferation.
Publisher: Wiley
Date: 31-12-2021
DOI: 10.1111/APA.16237
Abstract: To determine how well definitions of SIDS in the literature are being cited and referenced. The “PubMed” database was searched for “sudden infant death syndrome” from 2020 to 2021. Of 421 original papers, 50 were randomly selected and checked to determine whether one of the three internationally accepted definitions of SIDS: Seattle, NICHD and San Diego definitions had been cited/quoted in the text and correctly referenced. Papers that incorrectly cited or did not cite one standard definitions were assigned into: (i) those that used mis‐cited, idiosyncratic or other (alternative, non‐standard) definitions and, (ii) those where there was no definition. Fifty‐six per cent of papers correctly cited standard definitions, a 12% decrease from the 68% in a similar study in 2012. Of those only 22% both correctly cited/referenced one of the standard definitions. Major issues in 78% of papers involved citing one and referencing another standard definition ( N = 7, 14%), citing or referencing alternative, non‐standard definitions ( N = 8, 16%) or not citing or referencing any definition ( N = 24, 48%). There is an increasing trend to not follow standard definitions of SIDS. This may hinder data interpretation where cases have not been appropriately defined and negatively impact upon the validity of SIDS research.
Publisher: American Chemical Society (ACS)
Date: 06-07-2018
Abstract: Porous silicon nanoparticles (pSiNP), modified to target dendritic cells (DC), provide an alternate strategy for the delivery of immunosuppressive drugs. Here, we aimed to develop a DC-targeting pSiNP displaying c-type lectin, dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), and CD11c monoclonal antibodies. The in vivo tracking of these fluorescent DC-targeting nanoparticles was assessed in both C57BL/6 mice and common marmosets ( Callithrix jacchus) by intravenous injection (20 mg/kg). Rapamycin and ovalbumin (OVA)
Publisher: Wiley
Date: 2020
DOI: 10.1002/CTI2.1223
No related grants have been discovered for Sebastian Sterling.