ORCID Profile
0000-0002-9814-0049
Current Organisation
University of Oxford
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Publisher: Springer Science and Business Media LLC
Date: 24-09-2019
DOI: 10.1038/S41467-019-12026-7
Abstract: Most genome-wide association studies are based on s les of European descent. We assess whether the genetic determinants of blood lipids, a major cardiovascular risk factor, are shared across populations. Genetic correlations for lipids between European-ancestry and Asian cohorts are not significantly different from 1. A genetic risk score based on LDL-cholesterol-associated loci has consistent effects on serum levels in s les from the UK, Uganda and Greece ( r = 0.23–0.28, p 1.9 × 10 −14 ). Overall, there is evidence of reproducibility for ~75% of the major lipid loci from European discovery studies, except triglyceride loci in the Ugandan s les (10% of loci). In idual transferable loci are identified using trans-ethnic colocalization. Ten of fourteen loci not transferable to the Ugandan population have pleiotropic associations with BMI in Europeans none of the transferable loci do. The non-transferable loci might affect lipids by modifying food intake in environments rich in certain nutrients, which suggests a potential role for gene-environment interactions.
Publisher: MDPI AG
Date: 04-03-2017
DOI: 10.3390/NU9030232
Publisher: MDPI AG
Date: 15-07-2015
DOI: 10.3390/NU7075253
Abstract: Limited evidence exists for the association between diet pattern and obesity phenotypes among Chinese adults. In the present study, we analyzed the cross-sectional data from 474,192 adults aged 30–79 years from the China Kadoorie Biobank baseline survey. Food consumption was collected by an interviewer-administered questionnaire. Three dietary patterns were extracted by factor analysis combined with cluster analysis. After being adjusted for potential confounders, in iduals following a traditional southern dietary pattern had the lowest body mass index (BMI) and waist circumference (WC) the Western/new affluence dietary pattern had the highest BMI and the traditional northern dietary pattern had the highest WC. Compared to the traditional southern dietary pattern in multivariable adjusted logistic models, in iduals following a Western/new affluence dietary pattern had a significantly increased risk of general obesity (prevalence ratio (PR): 1.06, 95% confidence interval (CI): 1.03–1.08) and central obesity (PR: 1.07, 95% CI: 1.06–1.08). The corresponding risks for the traditional northern dietary pattern were 1.05 (1.02–1.09) and 1.17 (1.25–1.18), respectively. In addition, the associations were modified by lifestyle behaviors, and the combined effects with alcohol drinking, tobacco smoking, and physical activity were analyzed. Further prospective studies are needed to elucidate the diet-obesity relationships.
Publisher: Cold Spring Harbor Laboratory
Date: 20-01-2019
DOI: 10.1101/525170
Abstract: The majority of genetic studies for cardiometabolic traits were based on s les with European ancestry. Our aim was to assess whether genetic variants associated with blood lipids, a major risk factor for CVD, are shared across different populations. We compared genetic associations with lipids between s les from Uganda (N=6,407), China (N=21,295), Japan (N=162,255), the UK (N=9,961) and Greece (N=3,586). Using simulations, we established trans-ethnic colocalization as a method to distinguish shared from population-specific trait loci. Genetic correlations for HDL, LDL and triglycerides between European ancestry and Asian cohorts were close to 1. A polygenic score based on established LDL-cholesterol-associated loci from European discovery s les had consistent effects on serum levels in s les from the UK, Uganda and Greek population isolates (r=0.23 to 0.28, p .9x10 −14 ). Overall, ~75% of the major lipid loci from European discovery studies displayed evidence of replication at p −3 , except triglyceride loci in the Ugandan s les of which only 10% replicated. Specific replicating loci were identified using trans-ethnic colocalization. Ten of the fourteen lipid loci that did not replicate in the Ugandan population had pleiotropic associations with BMI in European ancestry s les while none of the replicating loci did. While lipid associations were highly consistent across European and Asian populations, there was a lack of replication particularly for established triglyceride loci in the Ugandan population. These loci might affect lipids by modifying food intake or metabolism in an environment offering diets rich in certain nutrients. This suggests that gene-environment interactions could play an important role for the transferability of complex trait loci.
Publisher: Springer Science and Business Media LLC
Date: 31-05-2019
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 22-09-2017
Abstract: Self‐rated health ( SRH ) is a strong predictor of mortality in different populations. However, the associations between SRH measures and risk of ischemic heart disease ( IHD ) have not been extensively explored, especially in a Chinese population. More than 500 000 adults from 10 cities in China were followed from baseline (2004–2008) through December 31, 2013. Global and age‐comparative SRH were reported from baseline questionnaires. Incident IHD cases were identified through links to well‐established disease registry systems and the national health insurance system. During 3 423 542 person‐years of follow‐up, we identified 24 705 incident cases of IHD . In multivariable‐adjusted models, both global and age‐comparative SRH was significantly associated with incident IHD . Compared with excellent SRH , the hazard ratios for good, fair, and poor SRH were 1.02 (95% confidence interval [CI], 0.98–1.07), 1.32 (95% CI, 1.27–1.37), and 1.76 (95% CI, 1.68–1.85), respectively. Compared with better age‐comparative SRH , the hazard ratios for same and worse age‐comparative SRH were 1.23 (95% CI, 1.19–1.27) and 1.78 (95% CI, 1.70–1.86), respectively. The associations persisted in all subgroup analyses, although they were slightly modified by study location, education, and income levels. A simple questionnaire for self‐assessment of health status was significantly associated with incident IHD in Chinese adults. In iduals and healthcare providers can use SRH measures as a convenient tool for assessing future IHD risk.
Publisher: Springer Science and Business Media LLC
Date: 19-11-2019
DOI: 10.1007/S10654-019-00582-7
Abstract: Pregnancy and pregnancy loss may be associated with increased risk of diabetes in later life. However, the evidence is inconsistent and sparse, especially among East Asians where reproductive patterns differ importantly from those in the West. We examined the associations of pregnancy and pregnancy loss (miscarriage, induced abortion, and still birth) with the risk of incident diabetes in later life among Chinese women. In 2004–2008, the nationwide China Kadoorie Biobank recruited 302 669 women aged 30–79 years from 10 (5 urban, 5 rural) erse localities. During 9.2 years of follow-up, 7780 incident cases of diabetes were recorded among 273,383 women without prior diabetes and cardiovascular disease at baseline. Cox regression yielded multiple-adjusted hazard ratios (HRs) for the risk of diabetes associated with pregnancy and pregnancy loss. Overall, 99% of women had been pregnant, of whom 10%, 53%, and 6% reported having a history of miscarriage, induced abortion, and stillbirth, respectively. Among ever pregnant women, each additional pregnancy was associated with an adjusted HR of 1.04 (95% CI 1.03 1.06) for diabetes. Compared with those without pregnancy loss, women with a history of pregnancy loss had an adjusted HR of 1.07 (1.02 1.13) and the HRs increased with increasing number of pregnancy losses, irrespective of the number of livebirths the adjusted HR was 1.03 (1.00 1.05) for each additional pregnancy loss. The strength of the relationships differed marginally by type of pregnancy loss. Among Chinese women, a higher number of pregnancies and pregnancy losses were associated with a greater risk of diabetes.
Publisher: Oxford University Press (OUP)
Date: 08-2007
DOI: 10.1093/AJE/KWM161
Abstract: The associations of dietary total carbohydrates, overall glycemic index, total dietary glycemic load, total sugars, total starch, and total fiber with endometrial cancer risk were analyzed among 288,428 women in the European Prospective Investigation into Cancer and Nutrition cohort (1992-2004), including 710 incident cases diagnosed during a mean 6.4 years of follow-up. Cox proportional hazards models were used to estimate relative risks and 95% confidence intervals. There were no statistically significant associations with endometrial cancer risk for increasing quartile intakes of any of the exposure variables. However, in continuous models calibrated by using 24-hour recall values, the multivariable relative risks were 1.61 (95% confidence interval: 1.06, 2.45) per 100 g/day of total carbohydrates, 1.40 (95% confidence interval: 0.99, 1.99) per 50 units/day of total dietary glycemic load, and 1.36 (95% confidence interval: 1.05, 1.76) per 50 g/day of total sugars. These associations were stronger among women who had never used postmenopausal hormone therapy compared with ever users (total carbohydrates p(heterogeneity) = 0.04). Data suggest no association of overall glycemic index, total starch, and total fiber with risk, and a possible modest positive association of total carbohydrates, total dietary glycemic load, and total sugars with risk, particularly among never users of hormone replacement therapy.
Publisher: Elsevier BV
Date: 03-2009
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 06-11-2017
Abstract: Breastfeeding confers substantial benefits to child health and has also been associated with lower risk of maternal cardiovascular diseases ( CVDs ) in later life. However, the evidence on the effects of CVD is still inconsistent, especially in East Asians, in whom the frequency and duration of breastfeeding significantly differ from those in the West. In 2004–2008, the nationwide China Kadoorie Biobank recruited 0.5 million in iduals aged 30 to 79 years from 10 erse regions across China. During 8 years of follow‐up, 16 671 incident cases of coronary heart disease and 23 983 cases of stroke were recorded among 289 573 women without prior CVD at baseline. Cox regression yielded adjusted hazard ratios ( HR s) and 95% CIs for incident CVD by breastfeeding. Overall, ≈99% of women had given birth, among whom 97% reported a history of breastfeeding, with a median duration of 12 months per child. Compared with parous women who had never breastfed, ever breastfeeding was associated with a significantly lower risk of CVD , with adjusted HR s of 0.91 (95% CI, 0.84–0.99) for coronary heart disease and 0.92 (95% CI, 0.85–0.99) for stroke. Women who had breastfed for ≥24 months had an 18% ( HR, 0.82 0.77–0.87) lower risk of coronary heart disease and a 17% ( HR, 0.83 0.79–0.87) lower risk of stroke compared with women who had never breastfed. Among women who ever breastfed, each additional 6 months of breastfeeding per child was associated with an adjusted HR of 0.96 (95% CI, 0.94–0.98) for coronary heart disease and 0.97 (95% CI, 0.96–0.98) for stroke. Among Chinese women, a history of breastfeeding was associated with an ≈10% lower risk of CVD in later life and the magnitude of the inverse association was stronger among those with a longer duration of breastfeeding.
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Huaidong Du.