ORCID Profile
0000-0001-9665-5092
Current Organisations
General Atomics
,
Gulf Medical University
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Publisher: Springer Science and Business Media LLC
Date: 08-2014
Publisher: SAGE Publications
Date: 09-2010
Abstract: Dr Srinivas Sulugodu Ramachandra, Senior Lecturer at Kanti Devi Dental College, Dr Srikrishna Sulgodu Ramachandra, Assistant Professor at the Public Health Foundation of India, and Dr Mala Rao, Director of the Indian Institute of Public Health, argue that oral health is being neglected in the world’s second most populous country
Publisher: Wiley
Date: 09-06-2023
Publisher: Mark Allen Group
Date: 02-09-2015
Publisher: SAGE Publications
Date: 17-01-2014
Publisher: Bentham Science Publishers Ltd.
Date: 22-06-2023
DOI: 10.2174/18742106-V17-E230517-2022-143
Abstract: Adjuncts to mechanical debridement, including administration of systemically and locally delivered antimicrobials, are constantly evaluated to achieve additional benefits while treating peri-implantitis. However, the potential for the development of antimicrobial resistance limits their use. Evaluation of the use of lasers for the treatment of peri-implantitis has provided varying results. This study aimed to summarize the existing literature on the additional benefits of lasers as adjuncts to mechanical debridement while treating peri-implant diseases. Randomised clinical trials published in English till Sept 2022 in PubMed, Medline, and clinical trial registries using the MeSH terms “peri-implant diseases”, “peri-implant mucositis”, “peri-implantitis”, and “lasers”, were included in the study. Case reports, case series, longitudinal studies, and retrospective analysis were excluded. A total of fifteen (n=15) randomised clinical trials pertaining to peri-implantitis and three (n=3) trials pertaining to peri-implant mucositis were assessed. The trials assessed the use of diode, Nd: YAG, Er:YAG, CO 2 lasers, and photodynamic therapy as adjuncts in the treatment of peri-implant diseases. The existing evidence regarding the use of laser for peri-implant mucositis is inconclusive, whereas for peri-implantitis, the majority of the studies support the use of lasers. Future trials should utilize the 2018 classification of peri-implantitis, so that a comparison of trials based on the studied parameters would be more accurate.
Publisher: Springer Science and Business Media LLC
Date: 21-01-2022
Publisher: Medknow
Date: 2016
Abstract: Political crisis and worsening security situation in Egypt in late 2013 resulted in Malaysian students who were pursuing their dental education in Egypt being recalled home to Malaysia. The Ministry of Higher Education in Malaysia took steps to integrate these students into public and private universities in Malaysia. We used a questionnaire and informal interviews to learn from students returning from Egypt about their experiences transitioning from dental schools in Egypt to Malaysia. We discuss the challenges students faced with regards to credit transfer, pastoral care, the differences in the curriculum between the dental faculties of the two nations, and the financial implications of this disruption of their training. We live in a fragile world where similar political situations will surely arise again. The approaches used by the Malaysian government and the lessons learned from these students may help others. The perspectives of these students may help educators reintegrate expatriate students who are displaced by political instability back into the education system of their own countries.
Publisher: Mark Allen Group
Date: 02-06-2012
DOI: 10.12968/DENU.2012.39.5.364
Abstract: This case report describes the management of an 18-year-old female who presented with generalized aggressive periodontitis, gingival enlargement and a mesiodens. Diagnosis for aggressive periodontitis was determined based on history, clinical findings and radiographic examination. Treatment included oral prophylaxis, extraction of the mesiodens and elimination of infectious micro-organisms, using a combination of surgical intervention and antimicrobial therapy with long-term maintenance. Clinical Relevance: Presence of gingival enlargement in cases of aggressive periodontitis may be clinically confusing hence, the diagnosis should always be based on the patient's history as well as the clinical and radiographic findings.
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2RA03979F
Abstract: Our work developed a 3D SARS-CoV-2 antibody detection platform in non-invasive saliva s les using S1-RBD protein-immobilized 3D melt electrowritten poly(ε-caprolactone) scaffolds.
Publisher: E.U. European Publishing
Date: 2016
DOI: 10.18332/TPC/64807
Publisher: Wiley
Date: 28-08-2011
Publisher: Elsevier BV
Date: 2018
Publisher: Wiley
Date: 08-2023
DOI: 10.1002/MBO3.1377
Abstract: Oral biofilms are three‐dimensional (3D) complex entities initiating dental diseases and have been evaluated extensively in the scientific literature using several biofilm models and assessment techniques. The list of biofilm models and assessment techniques may overwhelm a novice biofilm researcher. This narrative review aims to summarize the existing literature on biofilm models and assessment techniques, providing additional information on selecting an appropriate model and corresponding assessment techniques, which may be useful as a guide to the beginner biofilm investigator and as a refresher to experienced researchers. The review addresses previously established 2D models, outlining their advantages and limitations based on the growth environment, availability of nutrients, and the number of bacterial species, while also exploring novel 3D biofilm models. The growth of biofilms on clinically relevant 3D models, particularly melt electrowritten fibrous scaffolds, is discussed with a specific focus that has not been previously reported. Relevant studies on validated oral microcosm models that have recently gaining prominence are summarized. The review analyses the advantages and limitations of biofilm assessment methods, including colony forming unit culture, crystal violet, 2,3‐bis‐(2‐methoxy‐4‐nitro‐5‐sulfophenyl)‐2H‐tetrazolium‐5‐carboxanilide inner salt assays, confocal microscopy, fluorescence in situ hybridization, scanning electron microscopy, quantitative polymerase chain reaction, and next‐generation sequencing. The use of more complex models with advanced assessment methodologies, subject to the availability of equipment/facilities, may help in developing clinically relevant biofilms and answering appropriate research questions.
Publisher: No publisher found
Date: 2023
Publisher: AIP Publishing
Date: 2012
DOI: 10.1063/1.3671908
Abstract: Time-gated radiography with monoenergetic 15-MeV protons, 3-MeV protons, and 4-MeV alpha particles has revealed a rich and complex evolution of electromagnetic field structures in and around imploding, directly driven inertial-confinement fusion (ICF) targets at the OMEGA laser facility. Plastic-shell capsules and solid plastic spheres were imaged during and after irradiation with ICF-relevant laser drive (up to 6 × 1014 W/cm2). Radial filaments appeared while the laser was on they filled, and were frozen into, the out-flowing corona, persisting until well after the end of the laser drive. Data from specially designed experiments indicate that the filaments were not generated by two-plasmon-decay instabilities or by Rayleigh-Taylor instabilities associated with shell acceleration. Before the onset of visible filamentation, quasi-spherical field structures appeared outside the capsule in the images in a form that suggests outgoing shells of net positive charge. We conjecture that these discrete shells are related to multiple peaks seen previously in the spectra of protons ablated from the targets.
Publisher: Medknow
Date: 2017
Publisher: Medknow
Date: 2013
Publisher: E.U. European Publishing
Date: 03-2018
DOI: 10.18332/TID/83984
Publisher: AIP Publishing
Date: 10-09-2012
DOI: 10.1063/1.4752012
Abstract: Measurements of the total energy carried by fast ablator-ions in direct-drive implosions on OMEGA have been conducted using magnetic and Thomson Parabola spectrometers. It is shown that the total laser energy lost to fast ablator-ions for plastic and glass targets is comparable and that it is a modest fraction of the incident laser energy (≲1%). These measurements have been used to infer a non-linear, voltage-dependent target capacitance (∼0.1 nF) associated with the space-charge that accelerates the fast-ions.
Publisher: Elsevier BV
Date: 09-2017
Publisher: Elsevier BV
Date: 09-2021
DOI: 10.1016/J.MSEC.2021.112297
Abstract: Peri-implantitis is a bacterially induced inflammatory disease which affects the hard and soft tissues around a dental implant. Microbial biofilm formation is an important causative factor in peri-implantitis. The aim of this study is to develop an effective multifunctional surface coating for antimicrobial property and to counteract oral biofilm-associated infections via a single polydopamine copper coating (PDAM@Cu) on titanium implant surface to regulate endogenous nitric oxide (NO) generation. PDAM@Cu coatings were made with different concentrations of CuCl NO release rates could be controlled with different Cu concentration in PDAM@Cu coatings. NO generated from the PDAM@Cu coatings effectively induced dispersal of biofilms shown by the reduction in biofilm biomass as well as reduced biofilm attachment in s les prepared with blood and NO donors. Cu ions released from the PDAM@Cu coatings resulted in killing of the dispersed bacteria, which was evidenced by the live/dead cell staining and reduced metabolic activity noted from the XTT assay. In contrast, s les prepared with saliva showed no significant reduction in biofilms, indicating the important effect of endogenously generated NO on biofilm dispersal. In conclusion, PDAM@Cu coatings with NO generating surfaces have a dual anti-biofilm function, with a synergistic effect on biofilm dispersal from regulated NO generation and bactericidal effects from Cu ions from the coatings.
Publisher: Elsevier BV
Date: 02-2023
Publisher: Springer Science and Business Media LLC
Date: 07-2015
Publisher: Dental Hypotheses
Date: 29-01-2011
Publisher: Dental Hypotheses
Date: 07-01-2011
Publisher: Medknow
Date: 2017
Publisher: Jaypee Brothers Medical Publishing
Date: 2013
DOI: 10.5005/JP-JOURNALS-10024-1399
Abstract: To report rare findings of oral and periodontal manifestations in a patient with Epidermal nevus syndrome (ENS). The ENS describes the rare association of an epidermal nevus with abnormalities of central nervous system, ocular and skeletal abnormalities. Reports of oral involvement have been few. Also, most of the intraoral lesions have been reported in patients with nevi that do not fulfill the criteria for the diagnosis of ENS. This report describes a case of ENS that, in addition to cutaneous manifestations showed skeletal involvement and intraoral manifestations such as the extension of the nevi on the face intraorally involving the labial mucosa, hypoplasia, hypodontia of teeth and severe periodontal destruction. Patients with extensive epidermal nevi and systemic abnormalities should be suspected of having the ENS. Evaluation and management of patients with ENS requires a multidisciplinary team approach involving the dermatologist, pediatrician, ophthalmologist, neurologist, genetist, plastic surgeon and orthopedic services. Although uncommonly described in association with ENS, significant intraoral lesions do occur. Periodontal manifestations as in our patient, which to our knowledge has not been described in association with ENS so far, may also be present. Alteration of the response of periodontal tissues to dental plaque in the presence of certain systemic diseases has been reported, but not in association with ENS. Severe periodontal destruction due to exaggerated response to dental plaque was seen in the present case. Hence, emphasis on oral hygiene maintenance in such patients is essential. Patients with ENS must be evaluated periodically as they show a persistent predisposition for the development of tumors Baliga V, Gopinath VPK, Baliga S, Ramachandra SS, Jithendra KD, Shetty S. Intraoral Manifestations in a Patient with Epidermal Nevus Syndrome . J Contemp Dent Pract 2013 (4):762-765.
Publisher: Springer Science and Business Media LLC
Date: 07-2014
Publisher: Medknow
Date: 2013
Publisher: Universitas Indonesia, Directorate of Research and Public Service
Date: 15-12-2017
Publisher: Springer Science and Business Media LLC
Date: 04-09-2013
DOI: 10.1007/S10561-013-9395-8
Abstract: As esthetics gain importance, periodontal plastic surgical procedures involving soft tissue grafts are becoming commoner both around natural teeth as well as around implants. Periodontal soft tissue grafts are primarily used for the purpose of root coverage and in pre-prosthetic surgery to thicken a gingival site or to improve the crestal volume. Soft tissue grafts are usually harvested from the palate. Periodontal plastic surgical procedures involving soft tissue grafts harvested from the palate have two surgical sites a recipient site and another donor site. Many patients are apprehensive about the soft tissue graft procedures, especially the creation of the second/donor surgical site in the palate. In the past decade, newer techniques and products have emerged which provide an option for the periodontist atient to avoid the second surgical site. MucoMatrixX, Alloderm(®), Platelet rich fibrin, Puros(®) Dermis and Mucograft(®) are the various options available to the practicing periodontist to avoid the second surgical site. Use of these soft tissue allografts in an apprehensive patient would decrease patient morbidity and increase patient's acceptance towards periodontal plastic surgical procedures.
Publisher: Springer Science and Business Media LLC
Date: 21-05-2015
DOI: 10.1057/JPHP.2015.16
Abstract: Shisha smoking, with origins in India and the Arab world, is today spreading rapidly into other parts of the world. One such region is Southeast Asia,where shisha bars are commonly seen around educational institutions. The general public remains unaware of the harmful effects of shisha smoking and many assume that shisha smoking does not involve tobacco. Shisha smoking is not adequately addressed in the current anti-tobacco policies by most governments of Southeast Asia. Only a few countries have already taken concrete measures of including shisha smoking in anti-tobacco policies. We highlight the emerging trend of shisha smoking in Southeast Asian nations, associated health effects, and the loopholes in the governmental policies that are being exploited by the vendors of shisha. While most research, taxation policies, and health education on tobacco-related products have focused on cigarettes, additional methods of tobacco delivery become more common.
Publisher: Medknow
Date: 2011
Abstract: Diabetes mellitus is a chronic metabolic disorder of the carbohydrate, protein and fat metabolism, resulting in increased blood glucose levels. Various complications of diabetes have been described with periodontitis being added as the sixth complication of diabetes mellitus. The aim of this study was to assess periodontal status and treatment needs (TN) in diabetic patients and to compare the findings between diabetic and non-diabetic in iduals using community periodontal index (CPI). We evaluated the periodontal status and periodontal TN in diabetic and non-diabetic in iduals in Guwahati, Assam. A total of 459 (223 diabetic and 236 non-diabetic) in iduals were assessed. A person was considered to be diabetic when his blood glucose levels were above 140 mg/dl under fasting condition and 200 mg/dl 2 hours postprandially. Periodontal status was assessed using CPI. Periodontal destruction was found to be increased in diabetic in iduals, with periodontal destruction increasing with increased blood glucose levels. The necessity of complex periodontal treatment also increased with increasing blood glucose levels. In iduals with diabetes are more prone to periodontal destruction, and hence, regular periodontal screening and treatment is essential in these in iduals.
Publisher: AIP Publishing
Date: 15-04-2015
DOI: 10.1063/1.4918355
Abstract: Charged-particle spectroscopy is used to assess implosion symmetry in ignition-scale indirect-drive implosions for the first time. Surrogate D3He gas-filled implosions at the National Ignition Facility produce energetic protons via D+3He fusion that are used to measure the implosion areal density (ρR) at the shock-bang time. By using protons produced several hundred ps before the main compression bang, the implosion is diagnosed in-flight at a convergence ratio of 3–5 just prior to peak velocity. This isolates acceleration-phase asymmetry growth. For many surrogate implosions, proton spectrometers placed at the north pole and equator reveal significant asymmetries with litudes routinely ≳10%, which are interpreted as ℓ=2 Legendre modes. With significant expected growth by stagnation, it is likely that these asymmetries would degrade the final implosion performance. X-ray self-emission images at stagnation show asymmetries that are positively correlated with the observed in-flight asymmetries and comparable in magnitude, contradicting growth models this suggests that the hot-spot shape does not reflect the stagnated shell shape or that significant residual kinetic energy exists at stagnation. More prolate implosions are observed when the laser drive is sustained (“no-coast”), implying a significant time-dependent asymmetry in peak drive.
Publisher: Wiley
Date: 05-2018
DOI: 10.1002/JPER.17-0482
Publisher: AIP Publishing
Date: 19-06-2012
DOI: 10.1063/1.4729672
Abstract: The compact Wedge Range Filter (WRF) proton spectrometer was developed for OMEGA and transferred to the National Ignition Facility (NIF) as a National Ignition C aign diagnostic. The WRF measures the spectrum of protons from D-3He reactions in tuning-c aign implosions containing D and 3He gas in this work we report on the first proton spectroscopy measurement on the NIF using WRFs. The energy downshift of the 14.7-MeV proton is directly related to the total ρR through the plasma stopping power. Additionally, the shock proton yield is measured, which is a metric of the final merged shock strength.
Publisher: Elsevier BV
Date: 10-2022
Publisher: MDPI AG
Date: 03-09-2022
DOI: 10.3390/MICROORGANISMS10091783
Abstract: Numerous in vitro studies highlight the role of quorum sensing in the pathogenicity and virulence of biofilms. This narrative review discusses general principles in quorum sensing, including Gram-positive and Gram-negative models and the influence of flow, before focusing on quorum sensing and quorum quenching in cariogenic and periodontopathic biofilms. In cariology, quorum sensing centres on the role of Streptococcus mutans, and to a lesser extent Candida albicans, while Fusobacterium nucleatum and the red complex pathogens form the basis of the majority of the quorum sensing research on periodontopathic biofilms. Recent research highlights developments in quorum quenching, also known as quorum sensing inhibition, as a potential antimicrobial tool to attenuate the pathogenicity of oral biofilms by the inhibition of bacterial signalling networks. Quorum quenchers may be synthetic or derived from plant or bacterial products, or human saliva. Furthermore, biofilm inhibition by coating quorum sensing inhibitors on dental implant surfaces provides another potential application of quorum quenching technologies in dentistry. While the body of predominantly in vitro research presented here is steadily growing, the clinical value of quorum sensing inhibitors against in vivo oral polymicrobial biofilms needs to be ascertained.
Publisher: Siree Journals
Date: 2017
Publisher: American Chemical Society (ACS)
Date: 09-05-2022
Abstract: Zinc (Zn) has recently been identified as an auspicious biodegradable metal for medical implants and devices due to its tunable mechanical properties and good biocompatibility. However, the slow corrosion rate of Zn in a physiological environment does not meet the requirements for biodegradable implants, hindering its clinical translation. The present study aimed to accelerate the corrosion rate of pure Zn by utilizing acid etching to roughen the surface and increase the substrate surface area. The effects of acid etching on surface morphology, surface roughness, tensile properties, hardness, electrochemical corrosion and degradation behavior, cytocompatibility, direct cell attachment, and biofilm formation were investigated. Interestingly, acid-treated Zn showed an exceptionally high rate of corrosion (∼226-125 μm/year) compared to untreated Zn (∼62 μm/year), attributed to the increased surface roughness (
Publisher: E.U. European Publishing
Date: 06-03-2017
DOI: 10.18332/TPC/68748
Publisher: Medknow
Date: 2016
Publisher: AIP Publishing
Date: 11-2014
DOI: 10.1063/1.4900621
Abstract: The effects of shock dynamics on compressibility of indirect-drive ignition-scale surrogate implosions, CH shells filled with D3He gas, have been studied using charged-particle spectroscopy. Spectral measurements of D3He protons produced at the shock-bang time probe the shock dynamics and in-flight characteristics of an implosion. The proton shock yield is found to vary by over an order of magnitude. A simple model relates the observed yield to incipient hot-spot adiabat, suggesting that implosions with rapid radiation-power increase during the main drive pulse may have a 2× higher hot-spot adiabat, potentially reducing compressibility. A self-consistent 1-D implosion model was used to infer the areal density (ρR) and the shell center-of-mass radius (Rcm) from the downshift of the shock-produced D3He protons. The observed ρR at shock-bang time is substantially higher for implosions, where the laser drive is on until near the compression bang time (“short-coast”), while longer-coasting implosions have lower ρR. This corresponds to a much larger temporal difference between the shock- and compression-bang time in the long-coast implosions (∼800 ps) than in the short-coast (∼400 ps) this will be verified with a future direct bang-time diagnostic. This model-inferred differential bang time contradicts radiation-hydrodynamic simulations, which predict constant 700–800 ps differential independent of coasting time this result is potentially explained by uncertainties in modeling late-time ablation drive on the capsule. In an ignition experiment, an earlier shock-bang time resulting in an earlier onset of shell deceleration, potentially reducing compression and, thus, fuel ρR.
Publisher: Elsevier BV
Date: 04-2014
Publisher: Wiley
Date: 11-11-2022
DOI: 10.1002/JPER.22-0152
Abstract: This prospective cohort study aimed to evaluate the antibody responses in non‐invasive gingival crevicular fluid (GCF) and unstimulated whole saliva to the SARS‐CoV‐2 Spike unit 1 receptor‐binding domain (S1‐RBD) protein following administration of the mRNA BNT162b2 vaccine. This longitudinal study recruited 37 participants with no prior COVID‐19 exposure (eight people recruited prior to the COVID‐19 pandemic – labeled pre‐COVID, 16 vaccinated and 13 non‐vaccinated participants). An enzyme‐linked immunosorbent assay (ELISA) was used to determine antibody levels against S1‐RBD in saliva (n=90) and GCF (n=80) s les obtained at 1 and 3 weeks after dose 1, and 3 days, 7 days, and 3 weeks after dose 2. To determine previous SARS‐CoV‐2 infection status, anti‐nucleocapsid (N) Ig levels were determined in s les from the pre‐COVID (saliva as reference), non‐vaccinated (saliva and GCF), and vaccinated (saliva and GCF) participants at 1‐week post‐dose 1 using ELISA. Salivary levels of anti‐N antibodies measured in s les from vaccinated and nonvaccinated participants were comparable to those in pre‐COVID saliva s les collected between October 2018 and September 2019, thus confirming that all study participants had no prior SARS‐CoV‐2 infection. Overall, the levels of anti‐S1‐RBD antibodies peaked at 3 weeks after dose 2 in both saliva and GCF for all three immunoglobulin isotypes. Notably, the concentration of anti‐S1‐RBD antibodies in GCF was significantly higher than in saliva at all time points. This study establishes GCF and saliva as viable alternative non‐invasive sources to monitor levels of antibodies following vaccination, with GCF demonstrating feasibility as a biofluid source for the detection of antibodies against SARS‐CoV‐2 S1‐RBD antigen.
Publisher: University of Queensland Library
Date: 2022
DOI: 10.14264/B9FE031
Publisher: Medknow
Date: 2015
Publisher: Medknow
Date: 2019
Publisher: Bentham Science Publishers Ltd.
Date: 08-2023
DOI: 10.2174/1574886317666220514160507
Abstract: An invasive dental procedure is considered one of the risk factors for osteonecrosis of the jaw, especially among patients on bisphosphonates. This study aimed to determine the awareness and perceptions of medical practitioners regarding bisphosphonate-related osteonecrosis of the jaw (BRONJ), and their attitude towards dental referrals of such patients. This cross-sectional questionnaire-based study was conducted among medical practitioners in and around Mysore city, Karnataka, India, who commonly prescribe bisphosphonates. The s le included orthopaedic doctors, physicians, endocrinologists, and oncologists, ided based on the duration of practice and speciality. Data on the type of practice, awareness of BRONJ, referral to a dentist before/during therapy, and patient education about adverse effects, were collected and analyzed. A p-value ≤0.05 was considered statistically significant. Among 58 practitioners, 84.5% (49) were aware of the association between bisphosphonates and BRONJ, while 56.9% (33/58) believed dental procedure to be a risk factor, and 55.2% (32/58) did not recommend screening of the oral cavity by a dentist before initiation of bisphosphonate therapy. A majority (65.5%) of them educated their patients about adverse effects. Mean knowledge scores varied with specialization (post-graduation vs. super specialization = 1.43 vs. 2 p = 0.01) but not with the duration of practice ( = 10 years vs. years= 1.57 vs. 1.4 p= 0.24). The practitioners in our study were oblivious to dental procedures' role in the osteonecrosis of the jaw, highlighting the need for continuing education programs regarding BRONJ for medical and dental professionals. Clinicians updated regarding evidence-based practices and working cooperatively in teams may reduce the incidence of medication-related osteonecrosis of the jaw.
Publisher: Mark Allen Group
Date: 02-09-2015
Publisher: Wiley
Date: 19-09-2023
DOI: 10.1002/JPER.23-0086
Location: United States of America
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Srinivas Sulugodu Ramachandra.