ORCID Profile
0000-0002-1978-6301
Current Organisation
University of Nottingham
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Publisher: Public Library of Science (PLoS)
Date: 05-06-2015
Publisher: Springer Science and Business Media LLC
Date: 30-04-2013
DOI: 10.1038/MP.2013.44
Publisher: Proceedings of the National Academy of Sciences
Date: 13-05-2011
Publisher: Springer Science and Business Media LLC
Date: 15-04-2012
DOI: 10.1038/NG.2250
Publisher: Oxford University Press (OUP)
Date: 06-2016
Publisher: Public Library of Science (PLoS)
Date: 14-08-2014
Publisher: Springer Science and Business Media LLC
Date: 08-01-2014
Publisher: Elsevier BV
Date: 12-2014
Publisher: Proceedings of the National Academy of Sciences
Date: 06-04-2011
Abstract: Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is largely unknown, despite its clinical and societal importance. We report a genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol consumption (gram per day per kilogram body weight) among 12 population-based s les of European ancestry, comprising 26,316 in iduals, with replication genotyping in an additional 21,185 in iduals. SNP rs6943555 in autism susceptibility candidate 2 gene ( AUTS2 ) was associated with alcohol consumption at genome-wide significance ( P = 4 × 10 −8 to P = 4 × 10 −9 ). We found a genotype-specific expression of AUTS2 in 96 human prefrontal cortex s les ( P = 0.026) and significant ( P 0.017) differences in expression of AUTS2 in whole-brain extracts of mice selected for differences in voluntary alcohol consumption. Down-regulation of an AUTS2 homolog caused reduced alcohol sensitivity in Drosophila ( P 0.001). Our finding of a regulator of alcohol consumption adds knowledge to our understanding of genetic mechanisms influencing alcohol drinking behavior.
Publisher: Springer Science and Business Media LLC
Date: 29-04-2012
DOI: 10.1038/NN.3092
Abstract: The impulsive behavior that is often characteristic of adolescence may reflect underlying neurodevelopmental processes. Moreover, impulsivity is a multi-dimensional construct, and it is plausible that distinct brain networks contribute to its different cognitive, clinical and behavioral aspects. As these networks have not yet been described, we identified distinct cortical and subcortical networks underlying successful inhibitions and inhibition failures in a large s le (n = 1,896) of 14-year-old adolescents. Different networks were associated with drug use (n = 1,593) and attention-deficit hyperactivity disorder symptoms (n = 342). Hypofunctioning of a specific orbitofrontal cortical network was associated with likelihood of initiating drug use in early adolescence. Right inferior frontal activity was related to the speed of the inhibition process (n = 826) and use of illegal substances and associated with genetic variation in a norepinephrine transporter gene (n = 819). Our results indicate that both neural endophenotypes and genetic variation give rise to the various manifestations of impulsive behavior.
Publisher: Springer Science and Business Media LLC
Date: 09-04-2014
DOI: 10.1038/NPP.2014.83
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Anbarasu Lourdusamy.