ORCID Profile
0000-0002-5772-4937
Current Organisation
Humanitas University
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Publisher: Elsevier BV
Date: 08-2019
Publisher: Public Library of Science (PLoS)
Date: 17-10-2017
Publisher: Oxford University Press (OUP)
Date: 07-2015
DOI: 10.1111/BJD.13820
Publisher: Wiley
Date: 06-02-2018
DOI: 10.1111/JDV.14791
Abstract: Several dermoscopic and in vivo reflectance confocal microscopy (RCM) diagnostic criteria of lentigo maligna (LM)/lentigo maligna melanoma (LMM) have been identified. However, no study compared the diagnostic accuracy of these techniques. We evaluated the diagnostic accuracy of dermoscopy and RCM for LM/LMM using a holistic assessment of the images. A total of 223 facial lesions were evaluated by 21 experts. Diagnostic accuracy of the clinical, dermoscopic and RCM examination was compared. Interinvestigator variability and confidence level in the diagnosis were also evaluated. Overall diagnostic accuracy of the two imaging techniques was good (area under the curve of the sROC function: 0.89). RCM was more sensitive (80%, vs. 61%) and less specific (81% vs. 92%) than dermoscopy for LM/LMM. In particular, RCM showed a higher sensitivity for hypomelanotic and recurrent LM/LMM. RCM had a higher interinvestigator agreement and a higher confidence level in the diagnosis than dermoscopy. Reflectance confocal microscopy and dermoscopy are both useful techniques for the diagnosis of facial lesions and in particular LM/LMM. RCM is particularly suitable for the identification of hypomelanotic and recurrent LM/LMM.
Publisher: Wiley
Date: 08-02-2016
DOI: 10.1111/JDV.13548
Publisher: SPIE
Date: 20-03-2015
DOI: 10.1117/12.2081737
Publisher: Wiley
Date: 22-03-2020
DOI: 10.1111/AJD.13258
Publisher: Wiley
Date: 14-06-2016
DOI: 10.1111/JDV.13699
Abstract: Actinic keratosis (AK) usually co-exists in areas of severe photodamage, but the clinical applicability of reflectance confocal microscopy (RCM) in diagnosing AK currently depends on a set of parameters yet to be defined in comparison to photodamaged skin (PD). To correlate the RCM features of PD and AK with histopathology. Twenty participants with a mean age of 64 years and skin phototype I and II were studied. RCM was performed on two PD and one AK within a field of 25 cm A total of 57/60 areas were included. There were 43/57 (75%) and 14/57 (25%) histopathologically confirmed PD and AK respectively. In idual corneocytes, stratum corneum disruption, dermal inflammatory cells, increased vascularity/dilated vessels and solar elastosis were detected in PD and AK upon histopathology and RCM. The features in favour of AK were parakeratosis, hyperkeratosis, more severe keratinocyte pleomorphism and architectural disruption, and the presence of epidermal inflammatory cells. PD also demonstrated keratinocyte pleomorphism and architectural disruption though this was generally less severe than AK. A small subset of PD exhibited a comparable degree of keratinocyte pleomorphism and architectural disruption to the AKs in the cohort. The viable epidermis demonstrates PD and AK to be part of a disease continuum corresponding to field cancerization. In idual corneocytes, stratum corneum disruption, dermal inflammatory cells, increased vascularity/dilated vessels and solar elastosis may be present in PD whereas, parakeratosis and hyperkeratosis may represent the key to distinguishing AK from PD using RCM. The significance of epidermal inflammatory cells in the RCM diagnosis of AK remains to be elucidated.
Publisher: Public Library of Science (PLoS)
Date: 18-04-2016
No related grants have been discovered for Marco Ardigo.