ORCID Profile
0000-0001-8451-2529
Current Organisation
University of Adelaide
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Publisher: SAGE Publications
Date: 09-2015
Abstract: Evaluation of immune profiles in human breast cancer using high-sensitivity detection and analysis methods. Cohort comparative analysis studies of breast tissue. Human hospital and laboratory healthcare facilities. Women over 18 years. Evaluation of the comparative immunophenotype of human breast carcinoma and normal breast tissues. Leukocyte density and specific subgroups of lymphocytes and macrophages were generally higher in breast cancers compared to normal breast tissues. CD3, CD4, CD45RO, CD45RA(2H4), CD45 and HLA Class II (on TIL) were significantly expressed on breast tumour tissues compared with normal tissues ( p .01). Some 30% of T-cells were γδ-TCR positive, but the majority were αβ-TCR in type. CD19 (B-cell), CD14 (FMC32 and 33) and HLA Class I levels (epithelial and TIL) showed no significant differences. IL-2α receptor expression was low or absent on most TIL. High-sensitivity and image analysis techniques permitted accurate characterisation of the TIL infiltrate for immune profiling. Breast carcinoma showed predominance of CD4 T-cells of mainly memory phenotype. Normal breast tissues showed low leukocyte infiltration. Further correlation of these findings with clinical outcome, including survival, is proceeding with encouraging results.
Publisher: Oxford University Press
Date: 08-2019
DOI: 10.1093/MED/9780198810940.003.0021
Abstract: This chapter examines current literature regarding the impact of social cognition on psychosocial functioning in major depressive disorder, as well as potential treatment opportunities. Impairments of social cognition influence psychosocial functioning in the key domains of social performance, emotional/empathic performance, general cognitive functioning, and quality of life. Multiple treatment modalities have been used to target these difficulties, including antidepressant medication, psychotherapeutic approaches, and procedural interventions. Studies assess treatment efficacy based on the impact on facial affect recognition, interpretation of affective pictures, theory of mind performance, and prosody. Many current therapies are shown to have a normalizing effect for accuracy of interpretation and reduction in underlying negative interpretative bias. In particular, certain antidepressants seem to correct facial affect recognition deficits, while several psychotherapeutic approaches appear well suited for addressing impaired theory of mind or mood-congruent interpretative biases.
Publisher: Elsevier BV
Date: 06-2012
DOI: 10.1016/J.CARDFAIL.2012.03.005
Abstract: Cumulative dose-dependent nonischemic cardiomyopathy (NICM) remains a significant risk with the use of some chemotherapeutic agents. In this context, omega-3 polyunsaturated fatty acids (PUFA) have been investigated for their cardioprotective potential in rodent and in vitro models of anthracycline toxicity, with conflicting results. This study evaluated prophylactic omega-3 PUFA supplementation in a large-animal model of anthracycline-induced NICM. Merino sheep were randomized to oral drenching with omega-3 PUFA (fish oil n = 8) or olive oil placebo (n = 9) 3 weeks before commencing repeated intracoronary infusions of doxorubicin (DOX) to induce cardiac dysfunction. Cumulative DOX dose was 3.6 mg/kg. Drenching was continued for 12 weeks after final DOX exposure. Despite significant increases in tissue omega-3 PUFA levels (P < .05 vs placebo), omega-3-treated sheep displayed greater signs of anthracycline cardiotoxicity than placebo animals, consisting of left ventricular dilatation and a greater decline in ejection fraction (P < .05), although myocardial fibrosis burden was similar in both groups. Dietary intake of omega-3 PUFA fails to prevent and may indeed exacerbate DOX-induced cardiotoxicity. Clinical use of omega-3 supplementation during chemotherapy should be deferred until more information is available regarding the mechanisms of interaction between fatty acids and the myocardium during anthracycline exposure.
Publisher: SAGE Publications
Date: 28-01-2022
Publisher: SAGE Publications
Date: 14-08-2023
Publisher: SAGE Publications
Date: 04-2022
Publisher: Cambridge University Press
Date: 02-07-2015
Publisher: Springer Science and Business Media LLC
Date: 28-08-2020
Publisher: Springer Science and Business Media LLC
Date: 27-03-2012
DOI: 10.1007/S00330-012-2417-2
Abstract: To investigate whether grid-tag myocardial strain evaluation can characterise 'border-zone' peri-infarct region and identify patients at risk of ventricular arrhythmia as the peri-infarct myocardial zone may represent an important contributor to ventricular arrhythmia following ST-segment elevation myocardial infarction (STEMI). Forty-five patients with STEMI underwent cardiac magnetic resonance (CMR) imaging on days 3 and 90 following primary percutaneous coronary intervention (PCI). Circumferential peak circumferential systolic strain (CS) and strain rate (CSR) were calculated from grid-tagged images. Myocardial segments were classified into 'infarct', 'border-zone', 'adjacent' and 'remote' regions by late-gadolinium enhancement distribution. The relationship between CS and CSR and these distinct myocardial regions was assessed. Ambulatory Holter monitoring was performed 14 days post myocardial infarction (MI) to estimate ventricular arrhythmia risk via evaluation of heart-rate variability (HRV). We analysed 1,222 myocardial segments. Remote and adjacent regions had near-normal parameters of CS and CSR. Border-zone regions had intermediate CS (-9.0 ± 4.6 vs -5.9 ± 7.4, P < 0.001) and CSR (-86.4 ± 33.3 vs -73.5 ± 51.4, P < 0.001) severity compared with infarct regions. Patients with 'border-zone' peri-infarct regions had reduced very-low-frequency power on HRV analysis, which is a surrogate for ventricular arrhythmia risk (P = 0.03). Grid-tagged CMR-derived myocardial strain accurately characterises the mechanical characteristics of 'border-zone' peri-infarct region. Presence of 'border-zone' peri-infarct region correlated with a surrogate marker of heightened arrhythmia risk following STEMI. • Grid-tagged cardiac magnetic resonance (CMR) offers new insights into myocardial mechanical function. • Grid-tagged CMR identified different characteristics in 'border-zone' and 'adjacent' peri-infarct myocardial regions. • Reduced very-low-frequency (VLF) power is associated with arrhythmic and mortality risk. • The presence of 'border-zone' peri-infarct region correlated with reduced VLF power.
Publisher: Springer Science and Business Media LLC
Date: 26-02-2022
Publisher: SAGE Publications
Date: 06-09-2021
DOI: 10.1177/10398562211037335
Abstract: To identify all past publications from Australasian Psychiatry with subject matter particularly relevant for trainees. The results of such a search could then be collated into an easily accessible resource available to trainees and their supervisors. An electronic search of the journal’s back catalogue was conducted. Eighty-seven articles published on subjects particularly relevant for trainees were discovered from within Australasian Psychiatry. In particular, multiple useful resources were identified on the topics of the scholarly project and formulation skills. Australasian Psychiatry has published a wealth of literature that is likely to be of significant benefit for trainees as they work their way through the Royal Australian and New Zealand College of Psychiatrists training programme.
Publisher: SAGE Publications
Date: 17-04-2022
Publisher: Springer Science and Business Media LLC
Date: 12-04-2014
DOI: 10.1007/S00330-014-3137-6
Abstract: We evaluate whether circumferential strain derived from grid-tagged CMR is a better method for assessing improvement in segmental contractile function after STEMI compared to late gadolinium enhancement (LGE). STEMI patients post primary PCI underwent baseline CMR (day 3) and follow-up (day 90). Cine, grid-tagged and LGE images were acquired. Baseline LGE infarct hyperenhancement was categorised as ≤25 %, 26-50 %, 51-75 % and >75 % hyperenhancement. The segmental baseline circumferential strain (CS) and circumferential strain rate (CSR) were calculated from grid-tagged images. Segments demonstrating an improvement in wall motion of ≥1 grade compared to baseline were regarded as having improved segmental contractile-function. Forty-five patients (aged 58 ± 12 years) and 179 infarct segments were analysed. A baseline CS cutoff of -5 % had sensitivity of 89 % and specificity of 70 % for detection of improvement in segmental-contractile-function. On receiver-operating characteristic analysis for predicting improvement in contractile function, AUC for baseline CS (0.82) compared favourably to LGE hyperenhancement (0.68), MVO (0.67) and baseline-CSR (0.74). On comparison of AUCs, baseline CS was superior to LGE hyperenhancement and MVO in predicting improvement in contractile function (P < 0.001). On multivariate-analysis, baseline CS was the independent predictor of improvement in segmental contractile function (P < 0.001). Grid-tagged CMR-derived baseline CS is a superior predictor of improvement in segmental contractile function, providing incremental value when added to LGE hyperenhancement and MVO following STEMI. Baseline CS predicts contractile function recovery better than LGE and MVO following STEMI. Baseline CS predicts contractile function recovery better than baseline CSR following STEMI. Baseline CS provides incremental value to LGE and MVO following STEMI.
Publisher: SAGE Publications
Date: 31-10-2023
Publisher: Wiley
Date: 09-05-2022
DOI: 10.5694/MJA2.51529
Publisher: Magnolia Press
Date: 28-01-2022
DOI: 10.11646/ZOOTAXA.5093.4.3
Abstract: The type of the xeniid soft coral Sansibia flava (May, 1898) is re-described for the first time and its morphological diagnosis is presented. A subsequent integrated analysis of molecular and morphological characters of related Xeniidae, including species indigenous to the Indo-Pacific Ocean and invasive in the Atlantic (Brazil), led to the description of a new Sansibia species, as well as two new genera comprising an additional three new species. All of these taxa are encrusting, with polyps arising directly from a spreading basal membrane. Molecular phylogenetic analyses show that these genera are not sister taxa, thus further emphasizing the remarkable phylogenetic ersity of xeniids with such a growth form. The sclerites of all species are uniformly ellipsoid platelets, abundant throughout the colony. The species exhibit restricted, non-overlapping geographic ranges, with distinct genotypes (molecular operational taxonomic units) found in different marine realms. The results emphasize the importance of re-examination of original old type material while applying molecular phylogenetic analyses in order to delineate species boundaries and to recognize bio ersity patterns.
Publisher: Elsevier BV
Date: 04-2019
DOI: 10.1016/J.PSYCHRES.2019.02.035
Abstract: Social cognition is the ability to identify, perceive and interpret socially relevant information from the external world. It is an important adaptive trait, but is frequently affected in major depressive disorder by a mood-congruent interpretive bias. The present review examined the existing body of literature to determine (i) the impact social cognitive deficits in depression have on psychosocial functioning and (ii) the utility of psychotropic, psychological and procedural interventions employed to target these deficits. A total of 107 studies met inclusion criteria for review. Social cognitive performance was found to adversely impact depressed patients' psychosocial functioning across the key domains of general cognitive functioning and quality of life. Secondly, many current therapies were found to have a normalising effect on the social cognitive abilities of subjects with major depressive disorder, both at a neural and functional level. In particular, certain anti-depressant medications corrected facial affect recognition deficits, while several psychotherapeutic approaches improved impairments in theory of mind and negative interpretive bias.
Publisher: Frontiers Media SA
Date: 11-12-2014
Publisher: Springer Science and Business Media LLC
Date: 22-04-2016
Publisher: Frontiers Media SA
Date: 04-08-2015
Publisher: SAGE Publications
Date: 13-02-2023
Publisher: SAGE Publications
Date: 25-07-2023
DOI: 10.1177/10398562231191678
Abstract: To describe the importance of scientifically rigorous journal clubs in psychiatric education, and to provide a framework to effectively run journal clubs and appraise articles in a journal club format. This paper explores the concept of journal clubs and describes issues with the current state of academic science. It then lists factors associated with effectiveness of journal clubs and outlines a structure for appraising articles relevant to psychiatric practice in a journal club format. Current models of academic research and publishing, which can reward practices vulnerable to multiple forms of bias, make the consistent and valued use of journal clubs in psychiatric education and continuing professional development more important than ever. The literature shows that journal clubs can provide a valuable forum for mental health clinicians to update themselves on recent medical and scientific knowledge, while practicing and teaching skills in critical appraisal of research, statistics, clinical decision-making and epidemiology.
Publisher: SAGE Publications
Date: 02-2022
Publisher: SAGE Publications
Date: 15-09-2023
Publisher: SAGE Publications
Date: 06-2020
Abstract: Patients in regional, rural and remote communities experience perennial difficulties accessing mental health treatments in a timely manner, which contributes to inequitable outcomes when compared with their metropolitan counterparts. This situation frequently stems from a shortage of specialised face-to-face psychotherapy services available in local areas. The recent development of digital psychotherapy as an alternative treatment delivery method provides an opportunity to address this healthcare gap and to avoid the challenges related to workforce maldistribution. This article provides a targeted narrative review of the relevant evidence base, and discusses the potential applications within the rural and remote context. Multiple randomised controlled trials and a large meta-analysis demonstrate that digital psychotherapy, particularly cognitive-behavioural therapy, is as effective as face-to-face psychotherapy. Its use has consequently been endorsed across international clinical practice guidelines as an efficacious and practical way to provide mental healthcare. Despite this, the adoption of digital psychotherapeutic options has been limited to date. Increased awareness of the available options may improve access to psychological treatments in rural and remote populations. Digital psychotherapy should be considered an option for patients with depressive or anxiety disorders of mild-to-moderate severity.
No related grants have been discovered for Michael James Weightman.