ORCID Profile
0000-0001-8818-6070
Current Organisation
University of Adelaide
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Publisher: SPIE
Date: 04-03-2014
DOI: 10.1117/12.2038270
Publisher: AIP Publishing
Date: 02-09-2013
DOI: 10.1063/1.4820252
Abstract: We report on a resonant acoustic radiation force optical coherence elastography (ARF-OCE) technique that uses mechanical resonant frequency to characterize and identify tissues of different types. The linear dependency of the resonant frequency on the square root of Young's modulus was validated on silicone phantoms. Both the frequency response spectrum and the 3D imaging results from the agar phantoms with hard inclusions confirmed the feasibility of deploying the resonant frequency as a mechanical contrast for tissue imaging. Furthermore, the results of resonant ARF-OCE imaging of a post-mortem human coronary artery with atherosclerosis demonstrate the potential of the resonant ARF-OCE as a non-invasive method for imaging and characterizing vulnerable plaques.
Publisher: SPIE
Date: 09-02-2012
DOI: 10.1117/12.911635
Publisher: AIP Publishing
Date: 02-2021
DOI: 10.1063/5.0036300
Abstract: The tracking of small particles is an important but challenging task for biological applications such as disease diagnostics and medical research. Current methods are limited to the use of bulky instruments such as flow cytometers and microscopes. Here, a novel technique for the detection and measurement of micron-scale optical scatterers using a few-mode exposed-core microstructured optical fiber is proposed. Through selective mode launching combined with optical frequency domain reflectometry, scatterers located on the fiber core surface can be simultaneously mapped with both longitudinal and transverse information. This technique is demonstrated by detecting the two-dimensional positions of several femtosecond-laser-inscribed micron-scale ablations written at different locations on the fiber core surface. Due to the compact nature of the optical fiber and its local sensitivity to scatterers that are in close proximity to it, this technique has the potential for the measurement and detection of micron-scale particles in difficult to reach biological environments for in vivo applications.
Publisher: Elsevier BV
Date: 2021
DOI: 10.1016/J.JCMG.2021.03.028
Abstract: The majority of coronary atherothrombotic events presenting as myocardial infarction (MI) occur as a result of plaque rupture or erosion. Understanding the evolution from a stable plaque into a life-threatening, high-risk plaque is required for advancing clinical approaches to predict atherothrombotic events, and better treat coronary atherosclerosis. Unfortunately, none of the coronary imaging approaches used in clinical practice can reliably predict which plaques will cause an MI. Currently used imaging techniques mostly identify morphological features of plaques, but are not capable of detecting essential molecular characteristics known to be important drivers of future risk. To address this challenge, engineers, scientists, and clinicians have been working hand-in-hand to advance a variety of multimodality intravascular imaging techniques, whereby 2 or more complementary modalities are integrated into the same imaging catheter. Some of these have already been tested in early clinical studies, with other next-generation techniques also in development. This review examines these emerging hybrid intracoronary imaging techniques and discusses their strengths, limitations, and potential for clinical translation from both an engineering and clinical perspective.
Publisher: IEEE
Date: 09-2019
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2021
Publisher: Springer Science and Business Media LLC
Date: 04-10-2018
DOI: 10.1038/S41598-018-32407-0
Abstract: Miniaturised optical coherence tomography (OCT) fibre-optic probes have enabled high-resolution cross-sectional imaging deep within the body. However, existing OCT fibre-optic probe fabrication methods cannot generate miniaturised freeform optics, which limits our ability to fabricate probes with both complex optical function and dimensions comparable to the optical fibre diameter. Recently, major advances in two-photon direct laser writing have enabled 3D printing of arbitrary three-dimensional micro/nanostructures with a surface roughness acceptable for optical applications. Here, we demonstrate the feasibility of 3D printing of OCT probes. We evaluate the capability of this method based on a series of characterisation experiments. We report fabrication of a micro-optic containing an off-axis paraboloidal total internal reflecting surface, its integration as part of a common-path OCT probe, and demonstrate proof-of-principle imaging of biological s les.
Publisher: SPIE-Intl Soc Optical Eng
Date: 2011
DOI: 10.1117/1.3589097
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 07-2022
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 03-2015
Publisher: AIP Publishing
Date: 10-09-2018
DOI: 10.1063/1.5040861
Abstract: The probing of physiological processes in living organisms is a grand challenge that requires bespoke analytical tools. Optical fiber probes offer a minimally invasive approach to report physiological signals from specific locations inside the body. This perspective article discusses a wide range of such fiber probes developed at the Australian Research Council Centre of Excellence for Nanoscale BioPhotonics. Our fiber platforms use a range of sensing modalities, including embedded nanodiamonds for magnetometry, interferometric fiber cavities for refractive index sensing, and tailored metal coatings for surface plasmon resonance sensing. Other fiber probes exploit molecularly sensitive Raman scattering or fluorescence where optical fibers have been combined with chemical and immunosensors. Fiber imaging probes based on interferometry and computational imaging are also discussed as emerging in vivo diagnostic devices. We provide ex les to illustrate how the convergence of multiple scientific disciplines generates opportunities for the fiber probes to address key challenges in real-time in vivo diagnostics. These future fiber probes will enable the asking and answering of scientific questions that were never possible before.
Publisher: SPIE-Intl Soc Optical Eng
Date: 11-10-2017
Publisher: SPIE
Date: 30-12-2019
DOI: 10.1117/12.2541320
Publisher: Shanghai Institute of Optics and Fine Mechanics
Date: 2009
Publisher: The Optical Society
Date: 21-11-2014
DOI: 10.1364/OL.39.006652
Publisher: Elsevier BV
Date: 2014
Publisher: Wiley
Date: 29-03-2022
Abstract: A new fiber functionalization architecture for single‐fiber imaging and sensing is presented. 5(6)Carboxy‐seminaphthorhodafluor‐2 (a fluorescent pH sensor) is attached to a silk‐binding peptide and the complex added to aqueous silk fibroin protein. These bind with a K d of 36 µM as determined by a fluorescence polarization assay. The fiber is dip‐coated into the silk and peptide mixture, and scanning electron microscopy images reveal a uniform silk coating on the fiber tip. The coating is stable to repeated washes and does not affect the imaging light emitted from the fiber, which allows concurrent optical coherence tomography (OCT) imaging and pH sensing. Oocytes are metabolically stimulated with CoCl 2 to produce lactic acid, and a pH reduction of 0.04 is measured using the probe. The distance between fiber tip and oocyte is monitored by simultaneous OCT acquisitions to precisely position the probe. Lastly, OCT imaging of an ovary revealed the presence/absence of an oocyte within a follicle, an important step toward improving patient outcomes during in vitro fertilization, by limiting the number of invasive follicle punctures required. These results demonstrate the utility of this new coating to enable simultaneous OCT imaging and sensing, which provides significant insight into complex biological systems.
Publisher: SPIE
Date: 26-02-2015
DOI: 10.1117/12.2074696
Publisher: Springer Science and Business Media LLC
Date: 18-12-2015
DOI: 10.1038/SREP18406
Abstract: Atherosclerotic coronary artery disease (CAD) is the number one cause of death worldwide. The majority of CAD-induced deaths are due to the rupture of vulnerable plaques. Accurate assessment of plaques is crucial to optimize treatment and prevent death in patients with CAD. Current diagnostic techniques are often limited by either spatial resolution or penetration depth. Several studies have proved that the combined use of optical and ultrasonic imaging techniques increase diagnostic accuracy of vulnerable plaques. Here, we introduce an ultrafast optical-ultrasonic dual-modality imaging system and flexible miniaturized catheter, which enables the translation of this technology into clinical practice. This system can perform simultaneous optical coherence tomography (OCT)-intravascular ultrasound (IVUS) imaging at 72 frames per second safely in vivo , i.e., visualizing a 72 mm-long artery in 4 seconds. Results obtained in atherosclerotic rabbits in vivo and human coronary artery segments show that this ultrafast technique can rapidly provide volumetric mapping of plaques and clearly identify vulnerable plaques. By providing ultrafast imaging of arteries with high resolution and deep penetration depth simultaneously, this hybrid IVUS-OCT technology opens new and safe opportunities to evaluate in real-time the risk posed by plaques, detect vulnerable plaques and optimize treatment decisions.
Publisher: SPIE
Date: 02-03-2015
DOI: 10.1117/12.2074697
Publisher: Springer Singapore
Date: 10-10-2019
Publisher: MDPI AG
Date: 24-02-2023
DOI: 10.3390/BIOS13030319
Abstract: Atherosclerosis is a leading cause of morbidity and mortality, and high-risk atherosclerotic plaques can result in myocardial infarction, stroke, and/or sudden death. Various imaging and sensing techniques (e.g., ultrasound, optical coherence tomography, fluorescence, photoacoustic) have been developed for scanning inside blood vessels to provide accurate detection of high-risk atherosclerotic plaques. Nanoparticles have been utilized in intravascular imaging to enable targeted detection of high-risk plaques, to enhance image contrast, and in some applications to also provide therapeutic functions of atherosclerosis. In this paper, we review the recent progress on developing nanoparticles for intravascular imaging of atherosclerosis. We discuss the basic nanoparticle design principles, imaging modalities and instrumentations, and common targets for atherosclerosis. The review is concluded and highlighted with discussions on challenges and opportunities for bringing nanoparticles into in vivo (pre)clinical intravascular applications.
Publisher: Elsevier BV
Date: 03-2020
Publisher: IEEE
Date: 10-2012
Publisher: SPIE
Date: 28-04-2016
DOI: 10.1117/12.2214074
Publisher: SPIE
Date: 03-02-2012
DOI: 10.1117/12.905707
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2015
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1RA03584C
Abstract: We report a new approach to functionalise optical fibres to enable protein sensing, which controls the sensor molecule location either within the fibre tip coating or isolated to its exterior. This control dictates suitability for protein sensing.
Publisher: IEEE
Date: 07-2013
Publisher: Wiley
Date: 20-11-2022
Abstract: Optical techniques hold great potential to detect and monitor disease states as they are a fast, non‐invasive toolkit. Raman spectroscopy (RS) in particular is a powerful label‐free method capable of quantifying the biomolecular content of tissues. Still, spontaneous Raman scattering lacks information about tissue morphology due to its inability to rapidly assess a large field of view. Optical Coherence Tomography (OCT) is an interferometric optical method capable of fast, depth‐resolved imaging of tissue morphology, but lacks detailed molecular contrast. In many cases, pairing label‐free techniques into multimodal systems allows for a more erse field of applications. Integrating RS and OCT into a single instrument allows for both structural imaging and biochemical interrogation of tissues and therefore offers a more comprehensive means for clinical diagnosis. This review summarizes the efforts made to date toward combining spontaneous RS‐OCT instrumentation for biomedical analysis, including insights into primary design considerations and data interpretation.
Publisher: SPIE-Intl Soc Optical Eng
Date: 28-06-2012
Publisher: Shanghai Institute of Optics and Fine Mechanics
Date: 2016
Publisher: Elsevier BV
Date: 05-2020
Publisher: Springer Science and Business Media LLC
Date: 20-07-2020
DOI: 10.1038/S41377-020-00365-W
Abstract: Preclinical and clinical diagnostics increasingly rely on techniques to visualize internal organs at high resolution via endoscopes. Miniaturized endoscopic probes are necessary for imaging small luminal or delicate organs without causing trauma to tissue. However, current fabrication methods limit the imaging performance of highly miniaturized probes, restricting their widespread application. To overcome this limitation, we developed a novel ultrathin probe fabrication technique that utilizes 3D microprinting to reliably create side-facing freeform micro-optics ( µm diameter) on single-mode fibers. Using this technique, we built a fully functional ultrathin aberration-corrected optical coherence tomography probe. This is the smallest freeform 3D imaging probe yet reported, with a diameter of 0.457 mm, including the catheter sheath. We demonstrated image quality and mechanical flexibility by imaging atherosclerotic human and mouse arteries. The ability to provide microstructural information with the smallest optical coherence tomography catheter opens a gateway for novel minimally invasive applications in disease.
Publisher: Wiley
Date: 03-2022
Abstract: Multimodal microendoscopes enable co‐located structural and molecular measurements in vivo, thus providing useful insights into the pathological changes associated with disease. However, different optical imaging modalities often have conflicting optical requirements for optimal lens design. For ex le, a high numerical aperture (NA) lens is needed to realize high‐sensitivity fluorescence measurements. In contrast, optical coherence tomography (OCT) demands a low NA to achieve a large depth of focus. These competing requirements present a significant challenge in the design and fabrication of miniaturized imaging probes that are capable of supporting high‐quality multiple modalities simultaneously. An optical design is demonstrated which uses two‐photon 3D printing to create a miniaturized lens that is simultaneously optimized for these conflicting imaging modalities. The lens‐in‐lens design contains distinct but connected optical surfaces that separately address the needs of both fluorescence and OCT imaging within a lens of 330 µm diameter. This design shows an improvement in fluorescence sensitivity of x in contrast to more conventional fiber‐optic design approaches. This lens‐in‐lens is then integrated into an intravascular catheter probe with a diameter of 520 µm. The first simultaneous intravascular OCT and fluorescence imaging of a mouse artery in vivo is reported.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 03-2014
Publisher: MDPI AG
Date: 02-2022
DOI: 10.3390/BIOS12020090
Abstract: Optical fibers have been used to probe various tissue properties such as temperature, pH, absorption, and scattering. Combining different sensing and imaging modalities within a single fiber allows for increased sensitivity without compromising the compactness of an optical fiber probe. A double-clad fiber (DCF) can sustain concurrent propagation modes (single-mode, through its core, and multimode, through an inner cladding), making DCFs ideally suited for multimodal approaches. This study provides a technological review of how DCFs are used to combine multiple sensing functionalities and imaging modalities. Specifically, we discuss the working principles of DCF-based sensors and relevant instrumentation as well as fiber probe designs and functionalization schemes. Secondly, we review different applications using a DCF-based probe to perform multifunctional sensing and multimodal bioimaging.
Publisher: Samara National Research University
Date: 2015
Publisher: Elsevier BV
Date: 09-2014
Publisher: The Optical Society
Date: 06-04-2018
DOI: 10.1364/OL.43.001682
Publisher: SPIE-Intl Soc Optical Eng
Date: 18-05-2015
Publisher: AIP Publishing
Date: 24-08-2015
DOI: 10.1063/1.4929584
Abstract: Intravascular photoacoustic imaging at 1.7 μm spectral band has shown promising capabilities for lipid-rich vulnerable atherosclerotic plaque detection. In this work, we report a high speed catheter-based integrated intravascular photoacoustic/intravascular ultrasound (IVPA/IVUS) imaging system with a 500 Hz optical parametric oscillator laser at 1725 nm. A lipid-mimicking phantom and atherosclerotic rabbit abdominal aorta were imaged at 1 frame per second, which is two orders of magnitude faster than previously reported in IVPA imaging with the same wavelength. Clear photoacoustic signals by the absorption of lipid rich deposition demonstrated the ability of the system for high speed vulnerable atherosclerotic plaques detection.
Publisher: IEEE
Date: 08-2012
Publisher: SPIE
Date: 04-03-2014
DOI: 10.1117/12.2037893
Publisher: American Association for the Advancement of Science (AAAS)
Date: 07-12-2018
Abstract: A “smart” brain biopsy needle containing a tiny imaging probe is able to warn neurosurgeons about nearby blood vessels.
Publisher: Optica Publishing Group
Date: 09-07-2021
DOI: 10.1364/OE.431544
Abstract: Whispering gallery modes (WGMs) in micro-resonators are of interest due to their high Q-factors. Ultra-thin fiber tapers are widely deployed to couple light into micro-resonators but achieving stable and practical coupling for out-of-lab use remains challenging. Here, a new WGM coupling scheme using an exposed-core silica fiber (ECF) is proposed, which overcomes the challenge of using fragile fiber tapers. Microspheres are deposited onto the exposed channel for excitation via the evanescent field of the fiber’s guided modes. The outer jacket of the ECF partially encapsulates the microspheres, protecting them from external physical disturbance. By varying the mode launching conditions in this few-mode ECF, in combination with a Fano resonance effect, we demonstrate a high degree of tunability in the reflection spectrum. Furthermore, we show multi-particle WGM excitation, which could be controlled to occur either simultaneously or separately through controlling the ECF mode launching conditions. This work can bring value towards applications such as optical switches and modulators, multiplexed/distributed biosensing, and multi-point lasing, integrated in a single optical fiber device that avoids fiber post-processing.
Publisher: OSA
Date: 2018
Publisher: Optica Publishing Group
Date: 11-01-2010
DOI: 10.1364/OE.18.001261
Publisher: SPIE
Date: 04-03-2014
DOI: 10.1117/12.2037886
Publisher: MDPI AG
Date: 10-08-2023
DOI: 10.3390/DIAGNOSTICS13162642
Abstract: Malignant transformation of oral lichen planus (OLP) into oral squamous cell carcinoma is considered as one of the most serious complications of OLP. For the early detection of oral cancer in OLP follow-up, accurate localization of the OLP center is still difficult but often required for confirmatory biopsy with histopathological examination. Optical coherence tomography (OCT) offers the potential for more reliable biopsy s ling in the oral cavity as it is capable of non-invasively imaging the degenerated oral layer structure. In this case-series study with 15 patients, features of clinically classified forms of OLP in OCT cross-sections were registered and correlated with available histologic sections. Besides patients with reticular, atrophic, erosive and plaque-like OLP, two patients with leukoplakia were included for differentiation. The results show that OCT yields information about the epithelial surface, thickness and reflectivity, as well as the identifiability of the basement membrane and the vessel network, which could be used to complement the visual clinical appearance of OLP variants and allow a more accurate localization of the OLP center. This forms the basis for further studies on OCT-assisted non-invasive clinical classification of OLP, with the aim of enabling decision support for biopsy s ling in the future.
Publisher: Elsevier BV
Date: 09-2014
Publisher: SPIE-Intl Soc Optical Eng
Date: 21-10-2013
Publisher: Elsevier BV
Date: 03-2017
No related grants have been discovered for Jiawen Li.