ORCID Profile
0000-0002-9912-0031
Current Organisations
World Health Organization
,
Universidad de los Andes
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Publisher: Elsevier BV
Date: 11-2017
DOI: 10.1016/J.JCLINEPI.2017.08.008
Abstract: A living systematic review (LSR) should keep the review current as new research evidence emerges. Any meta-analyses included in the review will also need updating as new material is identified. If the aim of the review is solely to present the best current evidence standard meta-analysis may be sufficient, provided reviewers are aware that results may change at later updates. If the review is used in a decision-making context, more caution may be needed. When using standard meta-analysis methods, the chance of incorrectly concluding that any updated meta-analysis is statistically significant when there is no effect (the type I error) increases rapidly as more updates are performed. Inaccurate estimation of any heterogeneity across studies may also lead to inappropriate conclusions. This paper considers four methods to avoid some of these statistical problems when updating meta-analyses: two methods, that is, law of the iterated logarithm and the Shuster method control primarily for inflation of type I error and two other methods, that is, trial sequential analysis and sequential meta-analysis control for type I and II errors (failing to detect a genuine effect) and take account of heterogeneity. This paper compares the methods and considers how they could be applied to LSRs.
Publisher: IOP Publishing
Date: 02-2021
DOI: 10.1088/1742-6596/1804/1/012121
Abstract: Cloud computing provides scalable, on-demand, and highly available computing services over the Internet to both the public and organizations on a pay-per-use basis. It provides a variety of services such as networking, storage space, and applications. The key issue for cloud computing is ensuring the confidentiality and privacy of cloud resources and data. Enticing the user to purchase cloud services requires their trust which cannot be guaranteed unless the infrastructure is effectively protected because attacks at this level will threaten the whole system. To this end, we propose the Integrated Intrusion Prevention and Detection System (IIPDS) to prevent and detect different types of attacks to the infrastructure level of the cloud system. The proposed design uses Trusted Third Party (TTP) services and SSL/TLS protocols as intrusion prevention methods to secure the communication between the cloud provider and the user. It also uses multiple Intrusion Detection Systems (IDS) distributed over multiple cloud regions. The IDS system is capable of detecting known and unknown attacks using anomaly and rule-based (signature) intrusion detection techniques. The simulation results proved the efficiency of the system in detecting a wide range of attacks with low false positive alerts and low computational overhead.
Publisher: Elsevier BV
Date: 11-2017
DOI: 10.1016/J.JCLINEPI.2017.08.009
Abstract: While it is important for the evidence supporting practice guidelines to be current, that is often not the case. The advent of living systematic reviews has made the concept of "living guidelines" realistic, with the promise to provide timely, up-to-date and high-quality guidance to target users. We define living guidelines as an optimization of the guideline development process to allow updating in idual recommendations as soon as new relevant evidence becomes available. A major implication of that definition is that the unit of update is the in idual recommendation and not the whole guideline. We then discuss when living guidelines are appropriate, the workflows required to support them, the collaboration between living systematic reviews and living guideline teams, the thresholds for changing recommendations, and potential approaches to publication and dissemination. The success and sustainability of the concept of living guideline will depend on those of its major pillar, the living systematic review. We conclude that guideline developers should both experiment with and research the process of living guidelines.
Publisher: Wiley
Date: 09-04-2021
Publisher: Elsevier BV
Date: 10-2017
DOI: 10.1016/J.JACI.2017.03.050
Abstract: Allergic rhinitis (AR) affects 10% to 40% of the population. It reduces quality of life and school and work performance and is a frequent reason for office visits in general practice. Medical costs are large, but avoidable costs associated with lost work productivity are even larger than those incurred by asthma. New evidence has accumulated since the last revision of the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines in 2010, prompting its update. We sought to provide a targeted update of the ARIA guidelines. The ARIA guideline panel identified new clinical questions and selected questions requiring an update. We performed systematic reviews of health effects and the evidence about patients' values and preferences and resource requirements (up to June 2016). We followed the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) evidence-to-decision frameworks to develop recommendations. The 2016 revision of the ARIA guidelines provides both updated and new recommendations about the pharmacologic treatment of AR. Specifically, it addresses the relative merits of using oral H Appropriate treatment of AR might improve patients' quality of life and school and work productivity. ARIA recommendations support patients, their caregivers, and health care providers in choosing the optimal treatment.
Publisher: Elsevier BV
Date: 09-2021
Publisher: Elsevier BV
Date: 11-2017
DOI: 10.1016/J.JCLINEPI.2017.08.011
Abstract: New approaches to evidence synthesis, which use human effort and machine automation in mutually reinforcing ways, can enhance the feasibility and sustainability of living systematic reviews. Human effort is a scarce and valuable resource, required when automation is impossible or undesirable, and includes contributions from online communities ("crowds") as well as more conventional contributions from review authors and information specialists. Automation can assist with some systematic review tasks, including searching, eligibility assessment, identification and retrieval of full-text reports, extraction of data, and risk of bias assessment. Workflows can be developed in which human effort and machine automation can each enable the other to operate in more effective and efficient ways, offering substantial enhancement to the productivity of systematic reviews. This paper describes and discusses the potential-and limitations-of new ways of undertaking specific tasks in living systematic reviews, identifying areas where these human/machine "technologies" are already in use, and where further research and development is needed. While the context is living systematic reviews, many of these enabling technologies apply equally to standard approaches to systematic reviewing.
Publisher: IOP Publishing
Date: 02-2021
DOI: 10.1088/1742-6596/1804/1/012124
Abstract: The recent communication technology tends to be wirelessly for the mobility reason. Mobile Ad-hoc Network (MANET) can be established without any infrastructure or centralized controller. It can be constructed quickly in rural areas, military zones, and in emergency cases like earthquake. Three different types of routing protocols were categorized according to their work’s nature, which are Proactive, Reactive and Hybrid routing protocols. Due to the mobility characteristic of MANET nodes, routing protocols play important role in determining the network efficiency where the network topology is changed frequently. Many studies are conducted to analyze network performance and specify the best routing protocol using different simulation tools. In this paper, the performance of network is analyzed and evaluated when heterogeneous nodes are configured with these three types of protocols under heavy traffic load (VOIP). The result of our simulation shows that OLSR protocol has the highest throughput among others while DSR protocol shows the best performance in terms of Network load. Generally, the performance of routing protocol differs depending on the network type and use.
Publisher: Hindawi Limited
Date: 15-09-2021
DOI: 10.1111/IJCP.14805
Publisher: Elsevier BV
Date: 11-2017
DOI: 10.1016/J.JCLINEPI.2017.08.010
Abstract: Systematic reviews are difficult to keep up to date, but failure to do so leads to a decay in review currency, accuracy, and utility. We are developing a novel approach to systematic review updating termed "Living systematic review" (LSR): systematic reviews that are continually updated, incorporating relevant new evidence as it becomes available. LSRs may be particularly important in fields where research evidence is emerging rapidly, current evidence is uncertain, and new research may change policy or practice decisions. We hypothesize that a continual approach to updating will achieve greater currency and validity, and increase the benefits to end users, with feasible resource requirements over time.
No related grants have been discovered for Juan José Yepes-Nuñez.