ORCID Profile
0000-0002-4217-0214
Current Organisation
Bond University
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Publisher: Wiley
Date: 02-12-2021
DOI: 10.1111/BJET.13049
Publisher: Informa UK Limited
Date: 08-07-2022
Publisher: Wiley
Date: 21-02-2022
DOI: 10.1111/MEDU.14756
Publisher: American Physiological Society
Date: 09-2020
Publisher: Wiley
Date: 24-11-2021
DOI: 10.1002/NAU.24839
Abstract: Biological rationale suggests that parasympathomimetics (cholinergic receptor stimulating agents) could be beneficial for patients with underactive bladder. However, no systematic review with meta‐analysis addressing potential benefits or adverse effects exists. The aim of this review was to assess the effectiveness, both benefits and harms, of using parasympathomimetics for the treatment of underactive bladder. The protocol was registered in PROSPERO, and searches undertaken in PubMed, Embase, and CENTRAL, including randomized and non‐randomized controlled trials of patients with underactive bladder, comparing parasympathomimetic to placebo, no treatment, or other pharmaceuticals. Risk ratios, odds ratios, and mean differences were calculated. Twelve trials with 3024 participants were included. There was a significant difference between parasympathomimetics and comparators (favoring parasympathomimetics) in the number of patients with urinary retention (risk ratio 0.55, 95% confidence interval [CI] 0.3–0.98, p = 0.04, low quality of evidence). There was no difference in mean postvoid volume overall (MD −41.4 ml, 95% CI −92.0 to 9.1, p = 0.11, low quality of evidence). There was a significant difference at up to 1 week post‐intervention, favoring parasympathomimetics (MD −77.5 ml, 95% CI −90.9 to −64.1, p 0.001, low quality of evidence), but no difference at 1 month post‐intervention. There was no difference in adverse events (odds ratio 1.19, 95% CI 0.62–2.28, p = 0.6, moderate quality of evidence). The evidence supporting the use of parasympathomimetics is of low quality, with relatively short follow‐up durations. Overall, it is not possible to draw clear evidence‐based conclusions from the current literature, presenting the use of parasympathomimetics for treating underactive bladder as a key area that requires future well‐controlled clinical trials.
Publisher: American Physiological Society
Date: 12-2023
Abstract: Ninety-five percent of Westerners do not consume the recommended daily vegetable intake, exacerbating the incidence of obesity, malnutrition, and nutritional deficiencies such as fibre. This article reviews the literature from PUBMED, ERIC, and Web of Science, as well as Internet sites and government resources, to identify what should be considered important inclusions relating to dietary vegetable (including legumes and pulses) intake content in university Physiology subjects. The primary aim is to advance the competency relating to good nutrition knowledge for future health professionals to enable them to guide and counsel patients and clients toward better health. A review of the literature provides scant nutritional content relating to vegetable intake, particularly across Physiology subjects and health professional programs in general. A review of country dietary guidelines yielded discrepancies and ambiguity around recommended daily vegetable intake, including what constitutes essential vegetables. Educators responsible for embedding nutritional information in the curriculum would therefore be challenged to find reliable, evidence-based resources. Adding quality curriculum content on the importance of vegetable intake also promotes some of the Sustainable Development Goals (SDGs), including SDG 2 ( Zero Hunger), thereby contributing to SDG 3 ( Good Health and Well-Being). This article offers recommendations on how to embed content relating to the importance of dietary vegetables for good health, and guidance for educators of health professions programs wanting to improve their curriculum content relating to adequate nutrition.
Publisher: Springer Science and Business Media LLC
Date: 24-08-2020
Publisher: Frontiers Media SA
Date: 31-03-2022
DOI: 10.3389/FPHYS.2022.841181
Abstract: With many common bladder diseases arising due to abnormal contractions, a greater understanding of the receptor systems involved may aid the development of future treatments. The aim of this study was to identify any difference in the involvement of extracellular calcium (Ca 2+ ) across prominent contractile-mediating receptors within cells lining the bladder. Strips of porcine urothelium and lamina propria were isolated from the urinary bladder dome and mounted in isolated tissue baths containing Krebs-bicarbonate solution, perfused with carbogen gas at 37°C. Tissue contractions, as well as changes to the frequency and litude of spontaneous activity were recorded after the addition of muscarinic, histamine, 5-hydroxytryptamine, neurokinin-A, prostaglandin E2, and angiotensin II receptor agonists in the absence and presence of 1 µM nifedipine or nominally zero Ca 2+ solution. The absence of extracellular Ca 2+ influx after immersion into nominally zero Ca 2+ solution, or the addition of nifedipine, significantly inhibited the contractile responses ( p & 0.05 for all) after stimulation with carbachol (1 µM), histamine (100 µM), 5-hydroxytryptamine (100 µM), neurokinin-A (300 nM), prostaglandin E2 (10 µM), and angiotensin II (100 nM). On average, Ca 2+ influx from extracellular sources was responsible for between 20–50% of receptor-mediated contractions. This suggests that although the specific requirement of Ca 2+ on contractile responses varies depending on the receptor, extracellular Ca 2+ plays a key role in mediating G protein-coupled receptor contractions of the urothelium and lamina propria.
Publisher: Springer Science and Business Media LLC
Date: 23-09-2022
DOI: 10.1007/S40670-022-01635-5
Abstract: Disease education is a fundamental component in health science and medicine curricula, as it prepares students for their progression into health profession careers. However, this requires an ability to integrate concepts across multiple disciplines. Technology-enhanced interventions may bridge this gap, and this study assessed the effectiveness of a textbook-style or a three-dimensional mixed reality (MR, a hybrid of augmented and virtual reality) HoloLens resource for student learning and knowledge retention using asthma as a model of disease. Sixty-seven first-year undergraduate health science and medical students were randomized into two groups to complete a lesson on the physiology, anatomy, pathology, and pharmacology of asthma, delivered through either a textbook-style ( n = 34) or MR ( n = 33) resource. Participants took part in the study in small groups and completed the intervention and surveys in separate areas of a large laboratory space. A pre-test prior to the lesson included multiple-choice questions, with the post-test having additional multiple-choice questions to assess learning. A follow-up test to assess retention was performed two weeks later. Pre- and post-test scores revealed increased learning across both the textbook ( p = 0.001) and MR ( p = 0.05) interventions, although higher test results were obtained by those using the textbook-style resource ( p 0.05). There was no difference between groups in knowledge retention scores. Although the textbook-style resource was more effective for increasing test results, participants perceived MR as more favorable, highlighting the experience as enjoyable and useful. This study presents MR as an option for integration in cases where educators wish to enhance student enjoyment of the learning experience. However, the results suggest that traditional text-based resources persist as a fundamental delivery mode within a modern curriculum.
Publisher: Cambridge Media
Date: 11-2022
Publisher: Informa UK Limited
Date: 30-06-2023
Publisher: Springer International Publishing
Date: 2021
Publisher: American Physiological Society
Date: 12-2023
Publisher: Frontiers Media SA
Date: 03-11-2022
DOI: 10.3389/FPUBH.2022.1049932
Abstract: A Code Red has been declared for the planet and human health. Climate change (e.g., increasing temperatures, adverse weather events, rising sea levels) threatens the planet's already declining ecosystems. Without urgent action, all of Earth's inhabitants face an existential threat. Health professions education should therefore prepare learners to not only practice in a changing world, but authentic educational activities should also develop competencies for global and planetary citizenship. Planetary health has been integrated across the five-year Bond University (Australia) medical curriculum. It begins in the second week of Year 1 and ends with a session on Environmentally Sustainable Healthcare in the General Practice rotation in the final year. The purpose of this article is to describe the outcomes of the first 5 years (2018–2022) of a learner-centered planetary health assignment, underpinned by the 2030 United Nations (UN) Sustainable Development Goals (SDGs), in the second year of a five-year medical program. Using systems and/or design thinking with a focus on SDG13 ( Climate Action ) plus a second SDG of choice, self-selected teams of 4–6 students submit a protocol (with feedback) to develop a deliverable “product” for an intended audience. Data analysis of the first 5 years of implementation found that the most frequently selected SDGs in addition to SDG13 were: SDG12 Sustainable Production and Consumption (41% of teams), mostly relating to healthcare emissions and waste SDG3 Health and Well-being (22%), generally involving the impact of air pollution and SDG6 Clean Water and Sanitation (15%). A survey at the concluding conference garnered student feedback across various criteria. The planetary health assignment is authentic in that teams provide solutions to address climate change. Where appropriate, final “products” are sent to local or federal ministers for consideration (e.g., policy proposals) or integrated into the curriculum (e.g., learning modules). We believe that the competencies, attitudes, and values fostered through engagement with planetary health. Throughout the medical program, as evidenced by their evaluations, stands students in good stead to be change agents, not only in clinical practice but in society. An awareness has been created about the need for planetary citizenship in addition to global citizenship.
Publisher: American Physiological Society
Date: 03-2023
DOI: 10.1152/AJPCELL.00441.2022
Abstract: The influence of extracellular and intracellular calcium on smooth muscle contractile activity varies between organs. In response to G protein-coupled receptor (GPCR) stimulation, the urinary bladder detrusor muscle has shown a 70% dependence on extracellular calcium, whereas the urothelium and lamina propria (U& LP) has a 20%–50% dependence. However, as this only accounts for partial contractile activity, the contribution of intracellular calcium and calcium sensitization pathways remains unclear. This study assessed the role of intracellular signaling pathways on GPCR-mediated urinary bladder U& LP contraction. Porcine U& LP responses to activation of the G q/11 -coupled muscarinic, histamine, 5-hydroxytryptamine (serotonin), neurokinin, prostaglandin, and angiotensin II receptors were assessed with three selective inhibitors of store-released intracellular calcium, 2-aminoethyl diphenylborinate (2-APB), cyclopiazonic acid (CPA), and ruthenium red, and three Rho kinase inhibitors, fasudil, Y-27632, and GSK269962. There was no discernible impact on receptor agonist-induced contractions of the U& LP after blocking intracellular calcium pathways, suggesting that this tissue is more sensitive to alterations in the availability of extracellular calcium. However, an alternative mechanism of action for GPCR-mediated contraction was identified to be the activation of Rho kinase, such as when Y-27632 significantly reduced the GPCR-mediated contractile activity of the U& LP by approximately 50% ( P 0.05, n = 8). This suggests that contractile responses of the bladder U& LP do not involve a significant release of calcium from intracellular stores, but that G q/11 -coupled receptor activation causes calcium sensitization via Rho kinase. This study highlights a key role for Rho kinase in the urinary bladder, which may provide a novel target in the future pharmaceutical management of bladder contractile disorders.
Publisher: Informa UK Limited
Date: 07-09-2022
Publisher: Springer Science and Business Media LLC
Date: 13-02-2023
DOI: 10.1186/S41239-022-00378-Y
Abstract: Educational institutions are increasingly investing into digital delivery, acquiring new devices, and employing novel software and services. The rising costs associated with maintenance, in combination with increasing redundancy of older technologies, presents multiple challenges. While lesson content itself may not have changed, the educational landscape constantly evolves, where tertiary institutions are incorporating new modes of content delivery, hybrid-style learning, and interactive technologies. Investments into digital expansions must be taken with caution, particularly prior to the procurement of technology, with a need for the proposed interventions’ scalability, sustainability, and serviceability to be considered. This article presents the Triple-S framework for educators, administrators, and educational institutions, and outlines ex les of its application within curricula. The paper synthesises research evidence to provide the foundation underlying the key principles of the Triple-S framework, presenting a useful model to use when evaluating digital interventions. Utilising the framework for decisions regarding the acquisition of educational technology, devices, software, applications, and online resources can assist in the assurance of viable and appropriate investments. Graphical Abstract
Publisher: Wiley
Date: 26-02-2021
DOI: 10.1002/ASE.2049
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 31-05-2023
Publisher: Wiley
Date: 18-08-2022
DOI: 10.1111/MEDU.14892
Publisher: Springer Science and Business Media LLC
Date: 23-10-2023
Publisher: Elsevier BV
Date: 10-2022
No related grants have been discovered for Charlotte Phelps.