Publication
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
Publisher:
American Association for the Advancement of Science (AAAS)
Date:
12-01-2018
DOI:
10.1126/SCIENCE.AAN4472
Abstract: Malaria is a deadly disease with no effective vaccine. Physicians thus depend on antimalarial drugs to save lives, but such compounds are often rendered ineffective when parasites evolve resistance. Cowell et al. systematically studied patterns of Plasmodium falciparum genome evolution by analyzing the sequences of clones that were resistant to erse antimalarial compounds across the P. falciparum life cycle (see the Perspective by Carlton). The findings identify hitherto unrecognized drug targets and drug-resistance genes, as well as additional alleles in known drug-resistance genes. Science , this issue p. 191 see also p. 159