Gregory Crowther

Unitary and Nonunitary Quantum Cellular Automata with Rydberg Arrays

Publisher: American Physical Society (APS)

Date: 21-02-2020

DOI: 10.1103/PHYSREVLETT.124.070503

Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an In Silico Approach

Publisher: Public Library of Science (PLoS)

Date: 24-08-2010

DOI: 10.1371/JOURNAL.PNTD.0000804

Plasmodium Gametocyte Inhibition Identified from a Natural-Product-Based Fragment Library

Publisher: American Chemical Society (ACS)

Date: 03-10-2013

DOI: 10.1021/CB400582B

Abstract: Fragment-based screening is commonly used to identify compounds with relatively weak but efficient localized binding to protein surfaces. We used mass spectrometry to study fragment-sized three-dimensional natural products. We identified seven securinine-related compounds binding to Plasmodium falciparum 2'-deoxyuridine 5'-triphosphate nucleotidohydrolase (PfdUTPase). Securinine bound allosterically to PfdUTPase, enhancing enzyme activity and inhibiting viability of both P. falciparum gametocyte (sexual) and blood (asexual) stage parasites. Our results provide a new insight into mechanisms that may be applicable to transmission-blocking agents.

Integrating and Mining Helminth Genomes to Discover and Prioritize Novel Therapeutic Targets

Publisher: Wiley

Date: 18-07-2012

DOI: 10.1002/9783527652969.CH3

Genomic-scale prioritization of drug targets: the TDR Targets database

Publisher: Springer Science and Business Media LLC

Date: 17-10-2008

DOI: 10.1038/NRD2684

TDR Targets: a chemogenomics resource for neglected diseases

Publisher: Oxford University Press (OUP)

Date: 23-11-2011

DOI: 10.1093/NAR/GKR1053

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Publisher: Public Library of Science (PLoS)

Date: 28-07-2016

DOI: 10.1371/JOURNAL.PPAT.1005763

Bioaffinity Mass Spectrometry Screening

Publisher: Elsevier BV

Date: 02-2016

DOI: 10.1177/1087057115622605

Abstract: Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS or ESI-FTMS) was used to screen 192 natural product extracts and a 659-member natural product-based fragment library for bindings to a potential malaria drug target, Plasmodium falciparum Rab11a (PfRab11a, PF13_0119). One natural product extract and 11 fragments showed binding activity. A new natural product, arborside E, was identified from the active extract of Psydrax montigena as a weak binder. Its binding activity and inhibitory activity against PfRab11a were confirmed by ESI-FTMS titration experiments and an orthogonal enzyme assay.

Chemical genetics of Plasmodium falciparum

Publisher: Springer Science and Business Media LLC

Date: 05-2010

DOI: 10.1038/NATURE09099

Macquarie University

Location: Australia

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Everett Community College

Location: United States of America

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Williams College

Location: United States of America

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University Of Puget Sound

Location: United States of America

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University Of Washington

Location: United States of America

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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100042

Start Date: 2018

End Date: 12-2018

Amount: $621,834.00

Funder: Australian Research Council

ARC Centres Of Excellence - Grant ID: CE1101013

Start Date: 06-2011

End Date: 12-2017

Amount: $24,500,000.00

Funder: Australian Research Council

ARC Centres Of Excellence - Grant ID: CE170100009

Start Date: 2018

End Date: 06-2025

Amount: $31,900,000.00

Funder: Australian Research Council