ORCID Profile
0000-0002-6913-7545
Current Organisation
The University of Auckland
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Publisher: Physiome Incorporated
Date: 23-01-2023
DOI: 10.36903/PHYSIOME.21708176.V2
Abstract: The system of equations and figures presented in Imtiaz et al. (2002) are verified and reproduced in the current curation paper. Here, to demonstrate reproducibility, We describe the model encoded in the CellML and document the differences between our curated model and the one published by Imtiaz et al.. From the primary publication, we extracted data applying the Engauge digitizer software (Mitchell et al., 2020) to compare the current CellML simulation results against those in the primary publication. Editor's note: revised to remove LaTeX code from the abstract.
Publisher: Wiley
Date: 13-03-2023
DOI: 10.1111/NMO.14560
Abstract: The common occurrence of gastric disorders, the accelerating emphasis on the role of the gut‐brain axis, and development of realistic, predictive models of gastric function, all place emphasis on increasing understanding of the stomach and its control. However, the ways that regions of the stomach have been described anatomically, physiologically, and histologically do not align well. Mammalian single compartment stomachs can be considered as having four anatomical regions fundus, corpus, antrum, and pyloric sphincter. Functional regions are the proximal stomach, primarily concerned with adjusting gastric volume, the distal stomach, primarily involved in churning and propelling the content, and the pyloric sphincter that regulates passage of chyme into the duodenum. The proximal stomach extends from the dome of the fundus to a circumferential band where propulsive waves commence (slow waves of the pacemaker region), and the distal stomach consists of the pacemaker region and the more distal regions that are traversed by waves of excitation, that travel as far as the pyloric sphincter. Thus, the proximal stomach includes the fundus and different extents of the corpus, whereas the distal stomach consists of the remainder of the corpus and the antrum. The distributions of aglandular regions and of specialized glands, such as oxyntic glands, differ vastly between species and, across species, have little or no relation to anatomical or functional regions. It is hoped that this review helps to clarify nomenclature that defines gastric regions that will provide an improved basis for drawing conclusions for different investigations of the stomach.
Publisher: Physiome Incorporated
Date: 20-01-2023
DOI: 10.36903/PHYSIOME.21708176.V1
Abstract: The system of equations and figures presented in \\citet{imtiaz2002theoretical} are verified and reproduced in the current curation paper. Here, to demonstrate reproducibility, We describe the model encoded in the CellML and document the differences between our curated model and the one published by \\citeauthor{imtiaz2002theoretical}. From the primary publication, we extracted data applying the Engauge digitizer software \\citep{mark_mitchell_2020_3941227} to compare the current CellML simulation results against those in the primary publication.
Publisher: Physiome Incorporated
Date: 23-01-2023
DOI: 10.36903/PHYSIOME.21708176
Abstract: The system of equations and figures presented in Imtiaz et al. (2002) are verified and reproduced in the current curation paper. Here, to demonstrate reproducibility, We describe the model encoded in the CellML and document the differences between our curated model and the one published by Imtiaz et al.. From the primary publication, we extracted data applying the Engauge digitizer software (Mitchell et al., 2020) to compare the current CellML simulation results against those in the primary publication. Editor's note: revised to remove LaTeX code from the abstract.
Publisher: Wiley
Date: 13-08-2019
DOI: 10.1111/NMO.13704
Abstract: High-resolution colonic manometry is an emerging technique that has provided new insights into the pathophysiology of functional colorectal diseases. Prior studies have been limited by bulky, non-ambulatory acquisition systems, which have prevented mobilization during prolonged recordings. A novel ambulatory acquisition system for fiber-optic high-resolution colonic manometry was developed. Benchtop validation against a standard non-ambulatory system was performed using standardized calibration metrics. Clinical feasibility studies were conducted in three patients undergoing right hemicolectomy. Pressure profiles obtained from benchtop testing were near-identical using the ambulatory and the non-ambulatory systems. Clinical studies successfully demonstrated ambulatory data capture with patients freely mobilizing postoperatively during continuous recordings of >60 hours. The occurrence (P = .56), litude (P = .65), velocity (P = .10), and extent (P = .12) of colonic motor patterns were similar to those obtained in non-ambulatory studies. A novel ambulatory system for high-resolution colonic manometry has been developed and validated. This technique will facilitate prolonged ambulatory recordings of colonic motor activity, assisting with investigations into the role of colonic motility in disease states.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 07-2023
Publisher: Wiley
Date: 29-03-2023
DOI: 10.1111/NMO.14556
Abstract: Chronic gastric symptoms are common, however differentiating specific contributing mechanisms in in idual patients remains challenging. Abnormal gastric motility is present in a significant subgroup, but reliable methods for assessing gastric motor function in clinical practice are lacking. Body surface gastric mapping (BSGM) is a new diagnostic aid, employs multi‐electrode arrays to measure and map gastric myoelectrical activity non‐invasively in high resolution. Clinical adoption of BSGM is currently expanding following studies demonstrating the ability to achieve specific patient subgrouping, and subsequent regulatory clearances. An international working group was formed in order to standardize clinical BSGM methods, encompassing a technical group developing BSGM methods and a clinical advisory group. The working group performed a technical literature review and synthesis focusing on the rationale, principles, methods, and clinical applications of BSGM, with secondary review by the clinical group. The principles and validation of BSGM were evaluated, including key advances achieved over legacy electrogastrography (EGG). Methods for BSGM were reviewed, including device design considerations, patient preparation, test conduct, and data processing steps. Recent advances in BSGM test metrics and reference intervals are discussed, including four novel metrics, being the ‘principal gastric frequency’, BMI‐adjusted litude, Gastric Alimetry Rhythm Index™, and fed: fasted litude ratio. An additional essential element of BSGM has been the introduction of validated digital tools for standardized symptom profiling, performed simultaneously during testing. Specific phenotypes identifiable by BSGM and the associated symptom profiles were codified with reference to pathophysiology. Finally, knowledge gaps and priority areas for future BSGM research were also identified by the working group.
Publisher: Wiley
Date: 13-02-2022
DOI: 10.1111/NMO.14331
Abstract: Functional gastroduodenal disorders include functional dyspepsia, chronic nausea and vomiting syndromes, and gastroparesis. These disorders are common, but their overlapping symptomatology poses challenges to diagnosis, research, and therapy. This study aimed to introduce and validate a standardized patient symptom-logging system and App to aid in the accurate reporting of gastroduodenal symptoms for clinical and research applications. The system was implemented in an iOS App including pictographic symptom illustrations, and two validation studies were conducted. To assess convergent and concurrent validity, a erse cohort with chronic gastroduodenal symptoms undertook App-based symptom logging for 4 h after a test meal. In idual and total post-prandial symptom scores were averaged and correlated against two previously validated instruments: PAGI-SYM (for convergent validity) and PAGI-QOL (for concurrent validity). To assess face and content validity, semi-structured qualitative interviews were conducted with patients. App-based symptom reporting demonstrated robust convergent validity with PAGI-SYM measures of nausea (r The continuous patient symptom-logging App demonstrated robust convergent, concurrent, face, and content validity when used within a 4-h post-prandial test protocol. The App will enable standardized symptom reporting and is anticipated to provide utility in both research and clinical practice.
No related grants have been discovered for Peng Du.