ORCID Profile
0000-0002-9981-2150
Current Organisation
University of Wisconsin–Madison
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Wiley
Date: 29-04-2020
Publisher: Society of Nuclear Medicine
Date: 10-11-2016
Publisher: Wiley
Date: 16-08-2019
Publisher: Springer Science and Business Media LLC
Date: 03-02-2021
Publisher: Springer Science and Business Media LLC
Date: 20-11-2015
DOI: 10.1038/SREP16930
Abstract: Layered double hydroxide (LDH) nanomaterial has emerged as a novel delivery agent for biomedical applications due to its unique structure and properties. However, in vivo positron emission tomography (PET) imaging with LDH nanoparticles has not been achieved. The aim of this study is to explore chelator-free labeling of LDH nanoparticles with radioisotopes for in vivo PET imaging. Bivalent cation 64 Cu 2+ and trivalent cation 44 Sc 3+ were found to readily label LDH nanoparticles with excellent labeling efficiency and stability, whereas tetravalent cation 89 Zr 4+ could not label LDH since it does not fit into the LDH crystal structure. PET imaging shows that prominent tumor uptake was achieved in 4T1 breast cancer with 64 Cu-LDH-BSA via passive targeting alone (7.7 ± 0.1%ID/g at 16 h post-injection n = 3). These results support that LDH is a versatile platform that can be labeled with various bivalent and trivalent radiometals without comprising the native properties, highly desirable for PET image-guided drug delivery.
Publisher: Elsevier BV
Date: 12-2017
Location: United Kingdom of Great Britain and Northern Ireland
Location: United States of America
No related grants have been discovered for Todd Barnhart.