ORCID Profile
0000-0001-9516-5526
Current Organisation
Southern University of Science and Technology
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Publisher: Springer Science and Business Media LLC
Date: 31-07-2012
Publisher: Association for Computing Machinery (ACM)
Date: 14-03-2023
DOI: 10.1145/3568315
Abstract: Garg et al. (TCC 2018) defined the notion of registration-based encryption (RBE) where the private key generator (PKG) is decoupled from key management and replaced by a key curator (KC). KC does not possess any cryptographic secrets and only plays the role of aggregating the public keys of all the registered users and updating the public parameters whenever a new user joins the system, which solves the key escrow issue. Notwithstanding, RBE still places a significant amount of trust in KC, whose actions are not accountable, e.g., it could secretly register multiple keys for already registered users. In this article, we propose a blockchain-based RBE framework, which provides total transparency and decentralization of KC by leveraging smart contracts. Our framework transfers the right of key management from KC to in idual participants and keeps publicly upgradable parameters on-chain. We provide a basic construction that calculates the public parameter on-chain and an extended construction with better efficiency, which merely calculates the roots of trees on-chain. Our basic version is theoretically feasible, while the extended version is practically feasible. In particular, the enhanced scheme reduces computing complexity to a constant level. Our prototype implementation and evaluation results demonstrate that our extended construction is satisfactorily efficient.
Publisher: Wiley
Date: 13-07-2023
DOI: 10.1002/JMRS.705
Abstract: The paediatric radiation therapy group (PRTG) provided a multidisciplinary network to support patients accessing radiation therapy (RT). This study aims to evaluate the use and efficacy of behaviour therapy practices used by the PRTG. A retrospective cross‐sectional review of general anaesthetic (GA) utilisation for paediatric patients was completed between 1 January 2010 and 30 June 2014. The PRTG incorporated behavioural therapy techniques into all appointments but offered additional play appointments to children unable to comply with the requirements of RT. This aimed to increase their compliance and minimise GA use. Two‐hundred and seventy‐four patients had 5402 occasions of service, of which 1361 were delivered under GA (25.2%). Two‐hundred and fifty‐seven patients met the eligibility criteria. Patients under 8 years who required GA for their entire treatment reduced for each year of increase in age (odds ratio 0.37, 95% confidence interval 0.27–0.51, P 0.001). Participants 3 years and younger were shown not as likely to change their GA requirements with the use of play appointments. Seventy‐eight per cent (83/106) of 3–8‐year‐olds used no GA or ceased GA during treatment. Most paediatric patients years will gain minimal benefit to reduce GA use from additional play appointments. Children older than nine were not likely to require play appointments to be compliant with RT. Encouragingly, 53.3% of 3–8‐year‐olds who were categorised as full GA after CT planning did not continue to a full course of GA due to the behavioural therapy interventions of the PRTG.
Publisher: Wiley
Date: 2001
DOI: 10.1002/1097-0142(20010815)92:4<903::AID-CNCR1399>3.0.CO;2-2
Abstract: In patients undergoing radiation for cervical carcinoma, there is evidence that anemia is associated with an impaired outcome. For patients undergoing chemoradiation, there are no data available. The objective of this retrospective study was to examine the impact of anemia before and during chemoradiation in patients with cervical carcinoma. The authors collected data on hemoglobin (Hb) levels before and during treatment from 57 patients with cervical carcinoma. The stage of disease ranged between Stage IB and Stage IVA. All patients were treated with concurrent chemoradiation. Response to chemoradiation was evaluated by univariate and multivariate analyses. The mean Hb level at the time of presentation was 12.9 +/- 1.6 g/dL in patients with a complete clinical response (CCR) and 12.1 +/- 1.4 g/dL in those with persistent disease (P = 0.126). In patients with a CCR, the mean nadir Hb level was 11.1 +/- 1.3 g/dL, and in patients with treatment failure, it was 9.8 +/- 1.8 g/dL (P = 0.008). A univariate logistic regression model demonstrated that the nadir Hb level was the most predictive factor for treatment failure (relative risk, 1.92 P = 0.015) followed by disease stage (relative risk, 0.51 P = 0.074). In a multivariate model, the nadir Hb level remained the only prognostically relevant factor predicting the response to chemoradiation. Only patients with nadir Hb values > 11 g/dL throughout chemoradiation had a more than 90% chance of achieving a CCR. In patients undergoing chemoradiation for cervical carcinoma, the nadir Hb level is highly predictive of response to treatment, whereas the Hb level at the time of presentation is prognostically not significant.
Publisher: IEEE
Date: 03-05-2021
Publisher: Wiley
Date: 02-2012
DOI: 10.1111/J.1754-9485.2011.02330.X
Abstract: To evaluate the role of adjuvant radiotherapy in management of patients with tubular carcinoma of the breast. One hundred seventy-eight patients treated for tubular carcinoma were identified from the Queensland Radium Institute database. A retrospective review of medical records identified 115 patients meeting eligibility criteria: breast-conserving surgery for a histological diagnosis of tubular carcinoma, minimum follow up of 12 months and adequate medical records. Median follow up was 64 months. There were no significant differences between patient characteristics treated with and without radiotherapy. Median age at diagnosis was 54 (36-78) years. Ninety-five percent tumours were T1 and four patients had positive axillary lymph nodes. Of 94 patients treated with adjuvant radiotherapy, one developed local relapse. Five of 21 patients who did not have adjuvant radiotherapy failed locally. Five-year relapse-free survival with and without radiotherapy was 100 and 89%, respectively (hazard ratio for radiotherapy: 0.06 95% confidence interval 0.01-0.32, P = 0.001). Radiotherapy has a significant impact on relapse-free survival in patients treated with breast-conserving surgery for tubular carcinoma.
Publisher: Springer International Publishing
Date: 2020
Publisher: BMJ
Date: 09-2003
DOI: 10.1046/J.1525-1438.2003.13395.X
Abstract: To determine the impact of anemia before and during chemoradiation in patients with cervical cancer, we collected data on hemoglobin (Hb) levels before and during treatment from 60 unselected patients with cervical carcinoma. All patients had FIGO stage IB to IVA disease and were treated with concurrent chemoradiation for the aim of cure. Patients with an Hb value below or equal to the lower 25th quartile were considered anemic. Progression-free survival (PFS) was evaluated by univariate and multivariate analyses. After a median follow-up of 26.3 months, 20 patients developed disease progression. The lowest Hb during chemoradiation (nadir Hb), the stage of disease, and parametrial involvement were correlated significantly with PFS. On multivariate analysis, the nadir Hb (relative risk [RR] 0.29) and tumor stage (RR 3.4) remained the only prognostically relevant factors predicting PFS. At 60 months the PFS was 39.1% for anemic patients and 48.0% for nonanemic patients (P < 0.0002). In patients undergoing chemoradiation for cervical carcinoma, a low nadir Hb is highly predictive of shortened PFS, whereas the Hb before treatment is prognostically not significant.
Publisher: ACM
Date: 30-04-2023
No related grants have been discovered for Robyn Cheuk.