ORCID Profile
0000-0001-5867-4671
Current Organisation
University of Technology Sydney
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Publisher: American Chemical Society (ACS)
Date: 02-12-2019
DOI: 10.1021/ACS.NANOLETT.9B03777
Abstract: Although a variety of advanced sterilization materials and treatments have emerged, the complete elimination of bacterial infection, especially drug-resistant bacterial infection, remains an immense challenge. Here, we demonstrate the use of neutrophils loaded with photocatalytic nanoparticles to reduce bacterial infection. This method activates the immune system to achieve an anti-infection response. We prepared the photocatalytic nanoparticle-laden neutrophils in vivo through neutrophil phagocytosis. The resulting loaded cells retained the cell membrane functionality of the source cell, as well as the complete immune cell function of neutrophils, particularly the ability to recruit macrophages to the target area. Photocatalytic nanoparticle-laden neutrophils can target infection sites and release reactive oxygen species to induce the secretion of chemokines, leading to the targeted recruitment of macrophages and enhancing a powerful immune cascade. In a severe mouse infection model induced by pathogenic bacteria, small doses of photocatalytic nanoparticle-laden neutrophils showed a remarkable therapeutic effect by enhancing macrophage recruitment and the immune cascade.
Publisher: Public Library of Science (PLoS)
Date: 24-01-2023
DOI: 10.1371/JOURNAL.PWAT.0000070
Abstract: In urban Indonesia, 40 million people rely on groundwater self-supply, however the role of self-supply in securing household water provision remains unexplored. This study used a mixed-methods approach to understand the use and management of household self-supply in the Indonesian cities of Bekasi and Metro, where a high proportion of households rely on private wells for water supply. Self-supply was the preferred drinking water source because of its perceived safety, taste and appearance at both study sites. The most important attributes influencing choice of domestic water source were appearance, reliability and safety in Bekasi, and safety followed by convenience and reliability in Metro. Coping strategies to overcome quality and availability problems of self-supply included water treatment, switching from dug wells to deeper boreholes and the use of multiple water sources. All households reported boiling self-supplied water, however, the labor involved was tiring for some households, leading them to resort to alternative water sources. Reasons for non-use of alternative water sources such as refill water and public piped systems included a lack of trust in water quality and perceived poor taste. Regarding self-supply management, responsibilities and decision-making varied across households, but cooperation between men and women concerning workload was common. Women were mostly responsible for household water management, and men were mostly responsible for maintenance and repairs, cleanliness of the water source and financing. To support and regulate self-supply towards a safely managed water service, strategies for improvements should be considered not only at the source, but also at point-of-use, including promotion of safe household water treatment and management. Although self-supply was the main water source at these study sites, alternative sources such as refill water and public piped systems played an important role in supplementing inadequate supplies, and hence their safety and reliability should be considered when establishing support strategies.
Publisher: Elsevier BV
Date: 08-2021
Publisher: IWA Publishing
Date: 13-09-2023
Publisher: CSIRO Publishing
Date: 2023
DOI: 10.1071/PC23009
Publisher: American Geophysical Union (AGU)
Date: 10-2022
DOI: 10.1029/2021WR031843
Abstract: In urban Indonesia, more than 40 million people rely on groundwater self‐supply, but the extent to which self‐supply delivers safe water and the associated risk factors for fecal contamination remain unclear. This study quantified Escherichia coli ( E . coli ) for 511 self‐supply sources and at point‐of‐use for 173 households in the Indonesian cities of Bekasi and Metro. A structured questionnaire collected information about the household, water sources, and potential contamination sources. Univariate and multivariate logistic regression analysis examined risk factors for fecal contamination. E . coli was detected in 66% of sources, including 55% of boreholes, 64% of protected dug wells, and 82% of unprotected dug wells. Widespread boiling of water meant microbial quality improved significantly between source and point‐of‐use, with E . coli detected in 30% of self‐supply s les at point‐of‐use. Unprotected dug wells were significantly more likely to be contaminated than boreholes. In Bekasi, the analysis found a significant association between presence of E . coli and sanitation systems located within 10 m of the groundwater source. In Metro, poorer households had significantly higher odds of contamination than wealthier households. Other significant factors included shallower borehole depths in Bekasi, use of a rope and bucket, and absence of a concrete platform in Metro. In Bekasi, E . coli concentration at source was significantly associated with water quality at point‐of‐use. Risk of fecal contamination could be reduced by supporting households to invest in improved protection, and by facilitating promotion for safe household water treatment. Support for self‐supply improvements should be weighed against the expansion and improvement of piped water services.
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9EW00138G
Abstract: The assessment of a novel enzyme-based assay showed it to be reliable to detect and quantify E. coli in water.
Publisher: Wiley
Date: 13-06-2019
DOI: 10.1002/ECE3.5304
No related grants have been discovered for Franziska Genter.