ORCID Profile
0000-0003-2691-6423
Current Organisations
Institute of Biotechnology
,
University of Cumbria
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Publisher: Cold Spring Harbor Laboratory
Date: 31-08-2023
DOI: 10.1101/2023.08.29.555262
Abstract: Here we present a high-quality genome assembly of the mountain hare (Lepus timidus L.), based on a fibroblast cell line of a male specimen from Ilomantsi, Eastern Finland. The mountain hare represents the first Finnish contribution to the European Reference Genome Atlas pilot effort to generate reference genomes for European bio ersity. The genome was assembled using 25X PacBio HiFi sequencing data and scaffolded utilizing a Hi-C chromosome structure capture approach. After manual curation, the assembled genome length was 2,930,972,003 bp with N50 125.8Mb. 93.16% of the assembly could be assigned to 25 identified chromosomes (23 autosomes plus X and Y), matching the published karyotype. The chromosomes were named according to size. The genome has a high degree of completeness based on the BUSCO score (mammalia_odb10 database), Complete: 96.1% [Single copy: 93.1%, Duplicated: 3.0%], Fragmented 0.8%, and Missing 2.9%. The mitochondrial genome of the cell line was sequenced and assembled separately. Compared to the previous pseudoreference genome of L. timidus ssp. hibernicus Bell, assembled using the rabbit genome, this new reference genome represents the nominal subspecies and the species-specific chromosomal conformation. In addition to providing a useful comparison for population studies, the genome can offer insight into the chromosomal evolution among Glires in general and Lagomorpha in particular. The chromosomal assembly of the genome also demonstrates that the cell line has not gone through karyotypic changes during culture.
Publisher: American Society for Microbiology
Date: 11-2012
DOI: 10.1128/JB.00681-12
Abstract: We report the complete and annotated genome sequence of the plant-pathogenic enterobacterium Pectobacterium sp. strain SCC3193, a model strain isolated from potato in Finland. The Pectobacterium sp. SCC3193 genome consists of a 516,411-bp chromosome, with no plasmids.
Publisher: Springer Science and Business Media LLC
Date: 12-2017
Publisher: Informa UK Limited
Date: 02-01-2022
Publisher: Springer Science and Business Media LLC
Date: 03-10-2018
DOI: 10.1038/S41467-018-06138-9
Abstract: Yellow rust, caused by Puccinia striiformis f. sp. tritici ( Pst ), is a devastating fungal disease threatening much of global wheat production. Race-specific resistance ( R )-genes are used to control rust diseases, but the rapid emergence of virulent Pst races has prompted the search for a more durable resistance. Here, we report the cloning of Yr15 , a broad-spectrum R -gene derived from wild emmer wheat, which encodes a putative kinase-pseudokinase protein, designated as wheat tandem kinase 1, comprising a unique R -gene structure in wheat. The existence of a similar gene architecture in 92 putative proteins across the plant kingdom, including the barley RPG1 and a candidate for Ug8 , suggests that they are members of a distinct family of plant proteins, termed here tandem kinase-pseudokinases (TKPs). The presence of kinase-pseudokinase structure in both plant TKPs and the animal Janus kinases sheds light on the molecular evolution of immune responses across these two kingdoms.
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Diane Cox.