ORCID Profile
0000-0002-5814-7289
Current Organisation
Macquarie University
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Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 23-01-2009
DOI: 10.1002/HEP.22845
Abstract: Patients with fatty liver (FL) disease have a high risk of developing diabetes and cardiovascular diseases. The aim was to evaluate the association between FL, insulin resistance (IR), coronary heart disease (CHD) risk, and early atherosclerosis in a large European population (RISC Study). In 1,307 nondiabetic subjects (age 30-60 years) recruited at 19 centers, we evaluated liver enzymes, lipids, insulin sensitivity (by euglycemic-hyperinsulinemic cl ), glucose tolerance (by 75 g oral glucose tolerance test), carotid atherosclerosis as intima media thickness (IMT), CHD risk by the Framingham Heart study prediction score, and physical activity (by accelerometer). The presence of FL was estimated using the fatty liver index (FLI >60, likelihood >78% presence FL FLI 91% absence of FL). Subjects were ided into three groups: G1: FLI 60 (n = 234), G2: intermediate group (n = 465). Compared to G1, G3 included more men (70% versus 24%) and people with impaired glucose tolerance (23% versus 5%). IMT increased with FLI (G3 = 0.64 +/- 0.08 versus G1 = 0.58 +/- 0.08 mm, P < 0.0001). FLI was associated with increased CHD risk (r = 0.48), low-density lipoprotein cholesterol (r = 0.33), alanine aminotransferase (r = 0.48), aspartate aminotransferase (r = 0.25), systolic blood pressure (r = 0.39) and IMT (r = 0.30), and reduced insulin sensitivity (r = -0.43), high-density lipoprotein cholesterol (r = -0.50), adiponectin (r = -0.42), and physical activity (r = -0.16, all P < 0.0001). The correlations hold also in multivariate analysis after adjusting for age, gender, and recruiting center. In middle-age nondiabetic subjects, increased IMT, CHD risk, and reduced insulin sensitivity are associated with high values of FLI.
Publisher: Verein zur Forderung des Open Access Publizierens in den Quantenwissenschaften
Date: 28-04-2021
DOI: 10.22331/Q-2021-04-28-447
Abstract: Quantum data locking is a quantum phenomenon that allows us to encrypt a long message with a small secret key with information-theoretic security. This is in sharp contrast with classical information theory where, according to Shannon, the secret key needs to be at least as long as the message. Here we explore photonic architectures for quantum data locking, where information is encoded in multi-photon states and processed using multi-mode linear optics and photo-detection, with the goal of extending an initial secret key into a longer one. The secret key consumption depends on the number of modes and photons employed. In the no-collision limit, where the likelihood of photon bunching is suppressed, the key consumption is shown to be logarithmic in the dimensions of the system. Our protocol can be viewed as an application of the physics of Boson S ling to quantum cryptography. Experimental realisations are challenging but feasible with state-of-the-art technology, as techniques recently used to demonstrate Boson S ling can be adapted to our scheme (e.g., Phys. Rev. Lett. 123, 250503, 2019).
Publisher: Oxford University Press (OUP)
Date: 04-2009
DOI: 10.1038/AJH.2009.16
Abstract: The mechanisms by which menopause may influence the systemic subclinical atherosclerosis are unexplained. The aim of this cross-sectional study was to evaluate the associations between early menopause, established cardiovascular (c-v) risk factors, metabolic parameters (insulin secretion and sensitivity, plasma adiponectin), and carotid intima-media thickness (IMT) in healthy women. In 74 menopausal women (mean age = 51 +/- 3 years, mean duration of menopause = 2.9 +/- 1.2 years) and in 74 nonmenopausal women comparable for age and body mass index (BMI), common carotid artery (CCA) luminal diameter, and IMT in different carotid segments were measured in digitized ultrasound images. Insulin sensitivity and secretion were assessed using the euglycemic hyperinsulinemic cl technique and oral glucose tolerance test (OGTT). Insulin secretion was reconstructed by mathematical modeling. CCA diameter (5.55 +/- 0.46 vs. 5.21+/- 0.51 mm, P < 0.001), CCA IMT (608 +/- 78 vs. 576 +/- 74 microm, P < 0.01) and systolic blood pressure (BP) (117 +/- 12 vs. 113 +/- 11 mm Hg, P < 0.05) were higher in menopausal women, whereas CCA IMT/diameter ratio and IMT in other carotid segments did not differ between the groups. By multivariate models, independent predictors of CCA diameter were menopause and body weight (cumulative R2 = 0.37) and independent correlates of CCA IMT were luminal diameter, systolic BP and low-density lipoprotein (LDL) cholesterol (cumulative R2 = 0.48). Fasting insulin, insulin secretion, and sensitivity and plasma adiponectin were similar in the two groups and were not related to carotid IMT. Early menopause is associated with CCA remodeling, characterized by a proportional increase in luminal diameter and wall thickness, independent of atherosclerotic risk factors and metabolic variables.
Publisher: Oxford University Press (OUP)
Date: 08-2009
DOI: 10.1530/EJE-09-0058
Abstract: Fasting insulin concentrations are often used as a surrogate measure of insulin resistance. We investigated the relative contributions of fasting insulin and insulin resistance to cardiometabolic risk and preclinical atherosclerosis. The Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) cohort consists of 1326 European non-diabetic, overall healthy men and women aged 30–60 years. We performed standard oral glucose tolerance tests and hyperinsulinemic euglycemic cl s. As a general measure of cardiovascular risk, we assessed the prevalence of the metabolic syndrome in 1177 participants. Carotid artery intima media thickness (IMT) was measured by ultrasound to assess preclinical atherosclerosis. Fasting insulin was correlated with all elements of the metabolic syndrome. Insulin sensitivity ( M / I ) was correlated with most elements. The odds ratio for the metabolic syndrome of those in the highest quartile of fasting insulin compared with those in the lower quartiles was 5.4 (95% confidence interval (CI) 2.8–10.3, adjusted for insulin sensitivity) in men and 5.1 (2.6–9.9) in women. The odds ratio for metabolic syndrome of those with insulin sensitivity in the lowest quartile of the cohort compared with those in the higher quartiles was 2.4 (95% CI 1.3–4.7, adjusted for fasting insulin) in men and 1.6 (0.8–3.1) in women. Carotid IMT was only statistically significantly associated with fasting insulin in both men and women. Fasting insulin, a simple and practical measure, may be a stronger and independent contributor to cardiometabolic risk and atherosclerosis in a healthy population than hyperinsulinemic euglycemic cl -derived insulin sensitivity.
Publisher: American Physical Society (APS)
Date: 18-03-2020
Publisher: Optica Publishing Group
Date: 24-08-2022
DOI: 10.1364/OE.464108
Abstract: Integrated photonic architectures based on optical waveguides are one of the leading candidates for the future realisation of large-scale quantum computation. One of the central challenges in realising this goal is simultaneously minimising loss whilst maximising interferometric visibility within waveguide circuits. One approach is to reduce circuit complexity and depth. A major constraint in most planar waveguide systems is that beamsplitter transformations between distant optical modes require numerous intermediate SWAP operations to couple them into nearest neighbour proximity, each of which introduces loss and scattering. Here, we propose a 3D architecture which can significantly mitigate this problem by geometrically bypassing trivial intermediate operations. We demonstrate the viability of this concept by considering a worst-case 2D scenario, where we interfere the two most distant optical modes in a planar structure. Using femtosecond laser direct-writing technology we experimentally construct a 2D architecture to implement Hong-Ou-Mandel interference between its most distant modes, and a 3D one with corresponding physical dimensions, demonstrating significant improvement in both fidelity and efficiency in the latter case. In addition to improving fidelity and efficiency of in idual non-adjacent beamsplitter operations, this approach provides an avenue for reducing the optical depth of circuits comprising complex arrays of beamsplitter operations.
Publisher: Verein zur Forderung des Open Access Publizierens in den Quantenwissenschaften
Date: 03-08-2020
DOI: 10.22331/Q-2020-08-03-303
Abstract: Error-detection and correction are necessary prerequisites for any scalable quantum computing architecture. Given the inevitability of unwanted physical noise in quantum systems and the propensity for errors to spread as computations proceed, computational outcomes can become substantially corrupted. This observation applies regardless of the choice of physical implementation. In the context of photonic quantum information processing, there has recently been much interest in passive linear optics quantum computing, which includes boson-s ling, as this model eliminates the highly-challenging requirements for feed-forward via fast, active control. That is, these systems are passive by definition. In usual scenarios, error detection and correction techniques are inherently active , making them incompatible with this model, arousing suspicion that physical error processes may be an insurmountable obstacle. Here we explore a photonic error-detection technique, based on W-state encoding of photonic qubits, which is entirely passive, based on post-selection, and compatible with these near-term photonic architectures of interest. We show that this W-state redundant encoding techniques enables the suppression of dephasing noise on photonic qubits via simple fan-out style operations, implemented by optical Fourier transform networks, which can be readily realised today. The protocol effectively maps dephasing noise into heralding failures, with zero failure probability in the ideal no-noise limit. We present our scheme in the context of a single photonic qubit passing through a noisy communication or quantum memory channel, which has not been generalised to the more general context of full quantum computation.
Publisher: American Physical Society (APS)
Date: 03-05-2022
Publisher: The Endocrine Society
Date: 08-2007
DOI: 10.1210/JC.2007-0334
Abstract: Insulin resistance (IR) and obesity, especially abdominal obesity, are regarded as central pathophysiological features of a cluster of cardiovascular risk factors (CVRFs), but their relative roles remain undefined. Moreover, the differential impact of IR viz. insulin response has not been evaluated. The objective of this study was to dissect out the impact of obesity, abdominal obesity, and IR/insulin response on CVRF. This was a cross-sectional study. The study was conducted at 21 research centers in Europe. The study included a cohort of 1308 nondiabetic subjects [718 women and 590 men, age 30-60 yr, body mass index (BMI) 17-44 kg.m(-2)]. We measured IR (by a standardized euglycemic insulin cl ), waist girth, insulin response to an oral glucose tolerance test, and major CVRF, and analyzed their associations by multivariate models and factor analysis. BMI was positively related to all CVRFs. Waist circumference was related to higher blood pressure and serum triglycerides and lower high-density lipoprotein-cholesterol, IR to reduced glucose tolerance, higher free fatty acids, triglyceride and low-density lipoprotein-cholesterol, and lower high-density lipoprotein-cholesterol, and insulin response to higher heart rate, blood pressure and fasting glucose, and the same dyslipidemic profile as IR (P < or = 0.05 for all). By factor analysis, three main factors (related to IR, age, and fatness, respectively) appeared to underlie this pattern of associations. Each of BMI, waist girth, IR, and insulin response was independently associated with total CVRF load (all P < 0.001). When IR, fat mass and distribution, and insulin response are measured simultaneously in a large cohort, no one factor stands out as the sole driving force of the CVRF cluster, each being associated with one or more physiological pathways according to known cause-effect relationships.
Publisher: Oxford University Press (OUP)
Date: 12-02-0001
Abstract: The ADIPOQ gene encodes the protein adiponectin, and decreased circulating adiponectin levels have been observed in cardiovascular disease. We investigated the role of the ADIPOQ gene single-nucleotide polymorphisms (SNPs) A-11426G, G-11391A, C-11377G, and T45G with plasma adiponectin levels and common carotid artery intima media thickness (IMT) in a cohort of healthy subjects participating in the RISC (Relationship between Insulin Sensitivity and Cardiovascular disease) study. Anthropometric and metabolic assessment and B-mode ultrasound of the carotid IMT were measured in 1306 subjects [589 men 717 women, mean +/- SD age 43.8 +/- 8.3 years, BMI 25.5 +/- 4.0 kg/m(2)] recruited from 19 centres in 14 European countries. Carriers of the -11426G allele and homozygous carriers of the -11391G allele had significantly lower plasma adiponectin levels. These relationships remained significant after adjusting for age, sex, recruitment centre, and BMI. Carriers of SNP -11377G allele had significantly greater IMT values compared with C allele homozygotes [geometric mean (interquartile range) 601 (543-665) vs. 590 (537-647) mum, P = 0.021]. This relationship became stronger after correcting for key covariates, including plasma adiponectin levels (P = 0.011). Variation within the ADIPOQ gene promoter is directly associated with carotid IMT in healthy subjects and is independent of circulating adiponectin levels.
Publisher: Cambridge University Press
Date: 09-09-2021
Abstract: Following the emergence of quantum computing, the subsequent quantum revolution will be that of interconnecting in idual quantum computers at the global level. In the same way that classical computers only realised their full potential with the emergence of the internet, a fully-realised quantum internet is the next stage of evolution for quantum computation. This cutting-edge book examines in detail how the quantum internet would evolve in practise, focusing not only on the technology itself, but also the implications it will have economically and politically, with numerous non-technical sections throughout the text providing broader context to the discussion. The book begins with a description of classical networks before introducing the key concepts behind quantum networks, such as quantum internet protocols, quantum cryptography, and cloud quantum computing. Written in an engaging style and accessible to graduate students in physics, engineering, computer science and mathematics.
Publisher: Springer Science and Business Media LLC
Date: 07-09-2022
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Peter Rohde.