ORCID Profile
0000-0002-6039-0974
Current Organisation
The University of Newcastle
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: American Chemical Society (ACS)
Date: 07-01-2016
Publisher: Wiley
Date: 04-07-2016
Publisher: CSIRO Publishing
Date: 2012
DOI: 10.1071/CH12155
Abstract: Fluorescent molecularly imprinted polymers (MIP) specific for 2,4-dinitrotoluene (DNT) have been synthesised using a novel monomer N-2-propenyl-(5-dimethylamino)-1-naphthalene sulfonamide. Three formats of the polymer were produced: a traditional bulk monolith ground into particles, a flexible, but highly cross-linked plasticiser-modified free standing membrane, and a hybrid material consisting of particles embedded in a poly(acrylonitrile) phase inversed film. Within all materials, a clearly defined imprinting effect was observed upon exposure to DNT vapour at room temperature. In all cases, preferential rebinding of DNT to the molecularly imprinted materials (3–5 times) over their non-imprinted (NIP) equivalents was evident within min of contact with the DNT vapour stream. Fluorographic images of the fluorescent polymers showed the DNT binding-induced quenching to be significantly higher in the MIP material than in the non-imprinted control polymer.
Publisher: Springer US
Date: 2021
Publisher: Elsevier BV
Date: 2016
Publisher: Elsevier BV
Date: 12-2012
DOI: 10.1016/J.CHROMA.2012.09.100
Abstract: The application of capillary electrophoresis (CE) with on-line photodiode array detection to the analysis of processable poly(3,4-ethylenedioxythiophene) olystyrene sulfonate (PEDOT/PSS) aqueous dispersions is presented. The dispersions were prepared by oxidative polymerization of 3,4-ethylenedioxythiophene (EDOT) in the presence of PSS. The separation of PEDOT/PSS complexes and PSS was achieved using sodium borate (pH 9.2) in a fused silica capillary and positive polarity. The electrophoretic behavior and UV spectra of the negatively charged complexes were correlated to the amount of PEDOT attached to PSS. The ability of CE to predict the conductivity of films produced from spin coating of PEDOT/PSS dispersions was also proposed.
Publisher: American Chemical Society (ACS)
Date: 23-06-2018
Publisher: CSIRO Publishing
Date: 2004
DOI: 10.1071/CH04004
Abstract: Molecularly imprinted polymers (MIPs) selective for the phenolic contaminant 2,4,6-trichlorophenol (2,4,6-TCP) were prepared and evaluated in three porogens of differing character (hexane, acetonitrile, dichloromethane). Rebinding of 2,4,6-TCP was found to be most effective in dichloromethane (imprinting factor: 13.2). Competitive binding studies performed against a range of close structural analogues showed a high preference for the target molecule, although partial recognition towards 2,4-dichlorophenol was also observed. Specificity was found to be dependent upon the presence of ring chlorine on the target, which suggested that these atoms participate in secondary binding interactions that are essential for successful recognition in the polymer cavity.
Publisher: American Chemical Society (ACS)
Date: 17-08-2010
DOI: 10.1021/MA101237U
Publisher: Wiley
Date: 28-02-2001
DOI: 10.1002/POLA.1100
Publisher: Wiley
Date: 09-08-2017
DOI: 10.1002/JMR.2655
Abstract: The efficiency of the stoichiometric non-covalent imprinting of the imide 2,3,5-tri-O-acetyluridine (TAU) with 2,6-bis(acrylamido)pyridine (BAAPy) as functional monomer due to their strong donor-acceptor-donor/acceptor-donor-acceptor (DAD/ADA) hydrogen bond array interaction has been evaluated by bulk imprinting. This study is the first to investigate the imprinting and template rebinding efficiencies of the TAU/BAAPy molecularly imprinted polymeric (MIP) system prepared by precipitation polymerisation. We found that the stoichiometric 1:1 T:FM ratio has not been maintained in precipitation polymerisation and an optimal TAU:BAAPy ratio of 1:2.5 was obtained in acetonitrile without agitation affording an affinity constant (1.7 × 10
Publisher: Elsevier BV
Date: 04-2016
Publisher: Wiley
Date: 05-09-2018
DOI: 10.1002/JMR.2659
Abstract: Accurate quantification of histamine levels in food and in biological s les is important for monitoring the quality of food products and for the detection of pathophysiological conditions. In this study, solution processable histamine-imprinted microspheres were synthesized at 30°C via dilute free radical phototochemical polymerization technique using ethylene glycol dimethacrylate (EGDMA) as the crosslinker and methacrylic acid (MAA) as the monomer. The processability of the resulting polymer is dictated by the monomer feed concentration (eg, 4 wt% 80:20 EGDMA:MAA formulation) and solvent (acetonitrile). Whereas, the particle size is influenced by the monomer feed concentration, the presence of template molecule, and independent of the crosslinker content. Evaluation of the binding performance of the photochemically imprinted polymers (PCP) with different crosslinker content (80 and 90 wt%) indicated that the selective binding capacity was notably higher in PCP-80 (N= 16.0 μmol/g) compared to PCP-90 (N= 10.1 μmol/g) when analyzed via frontal analysis capillary electrophoresis (FACE) using Freundlich isotherm. In addition, PCP-80 microspheres are more selective toward histamine than conventional thermal polymers (CTP-80) prepared at 60°C in the presence of structural analogs such as histidine, imidazole, and tryptamine under cross-rebinding and competitive conditions. These results demonstrated that histamine-selective imprinted polymers can be obtained readily using room temperature photochemical polymerization where these materials can be subsequently used as recognition element for optical-based histamine sensing.
Publisher: Elsevier BV
Date: 10-2014
Publisher: Royal Society of Chemistry (RSC)
Date: 2009
DOI: 10.1039/B902468A
Publisher: Wiley
Date: 1998
DOI: 10.1002/(SICI)1099-1581(199801)9:1<94::AID-PAT738>3.0.CO;2-B
Publisher: MDPI AG
Date: 16-11-2018
DOI: 10.3390/MOLECULES23112996
Abstract: This study investigated the effect of feed formulation: the template:functional monomer (T:fM) and functional monomer:crosslinker (fM:X) ratios as well as the initiator concentration, on the binding performance and selectivity of caffeine (CAF) and theophylline (THP) imprinted polymers obtained by precipitation polymerisation in acetonitrile at 60 °C using methacrylic acid (MAA) and ethylene glycol dimethacrylate (EGDMA) as functional monomer and crosslinker, respectively. Template incorporation, monitored by quantitative 1H-NMR spectroscopy, ranged from 8 to 77% and was found to be more favourable at both high and low T:fM ratios, low fM:X ratio and high initiator concentration. The resulting T:fM ratio in most MIPs were found to be lower than their feed ratios. Incorporation of THP into the polymers was observed to be consistently higher than CAF and, for most MIPs, the observed binding capacities represent less than 10% of the incorporated template. Improved imprinting factors were obtained from molecularly imprinted polymers (MIPs) with high crosslinker content, i.e., fM:X ratio of 1:10, and high initiator concentration, i.e., initiator:total monomer (I:tM) ratio of 1:5, while T:fM ratio (1:2 to 1:8) was found not to influence binding capacities and imprinting factors (IF). The NIPs showed no preference for either CAF or THP in competitive selectivity studies while MIPs were observed to bind preferentially to their template with THP displaying higher selectivity (72–94%) than CAF (63–84%). Template selectivity was observed to increase with increasing initiator concentration, with MIPs from I:tM ratio of 1:5 shown to be the most selective towards CAF (84%) and THP (93%). The fM:X ratio only showed minimal effect on MIP selectivity. Overall, for the MIP systems under study, template incorporation, binding capacity, imprinting factor and selectivity are enhanced at a faster rate of polymerisation using an I:tM ratio of 1:5. Polymer particles obtained were between 66 to 140 nm, with MIPs generally smaller than their NIP counterparts, and have been observed to decrease with increasing T:fM and fM:X ratios and increase with increasing initiator concentration.
Publisher: American Chemical Society (ACS)
Date: 20-08-2012
DOI: 10.1021/IE300932Z
Publisher: CSIRO Publishing
Date: 2007
DOI: 10.1071/CH06284
Abstract: Molecularly imprinted polymers (MIPs) were generated for trans-aconitic acid 1 and cocaine 2 in a variety of porogens (CH3CN, CHCl3, [bmim][BF4], and [bmim][PF6]). MIP synthesis in either [bmim][BF4] or [bmim][PF6] resulted in significant acceleration of polymerization rates and, in the case of low temperature polymerizations, reactions were complete in less than 2 h, while no product was observed in the corresponding volatile organic carbon (VOC) porogen. In all instances, MIPs generated in [bmim][BF4] or [bmim][PF6] returned imprinting selectivities (I values) on par with or better than the corresponding MIP generated in VOCs. Imprinting values ranged between I = 1 and 2.9, with rebinding limited to 1 h. MIP synthesis conducted at low temperature (5°C) afforded the highest I values. Scanning electron microscopy examination of MIP morphology highlighted an unexpected template effect with MIP structure varying between discrete nanoparticles and robust monoliths. This template–monomer interaction was also observed in the rates of polymerizations with differences noted in reaction times for 1 and 2 MIPs, thus providing indirect conformation of our previously proposed use of molecular modelling–nuclear magnetic resonance titrations (the MM-NMR method) in the design phase of MIP generation. In addition, considerable batch-to-batch rebinding selectivities were observed.
Publisher: Elsevier BV
Date: 2015
Publisher: Royal Society of Chemistry (RSC)
Date: 2007
DOI: 10.1039/B708660A
Abstract: Our group is currently developing in-field detection systems alongside the Australian Federal Police Forensic Services utilising molecularly imprinted polymers as the recognition elements. This review looks at MIP synthesis and our perceptions of future directions from an Australian and forensic perspective.
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3OB40332G
Abstract: Molecularly imprinted polymeric films (MIPFs) highly selective to 1R,2S(-)ephedrine (L-ephedrine, EPD) were produced by phase inversion post-polymerization imprinting on poly(acrylonitrile-co-methyl methacrylate-co-acrylic acid) (PAMA) terpolymers. The inclusion of methyl methacrylate (MMA) to the polymer formulation resulted in enhanced EPD selectivity which appears to be dictated by polymer composition to achieve the necessary balance between polymer rigidity and porosity. Substitution of MMA with methyl acrylate, ethyl acrylate and n-butyl acrylate resulted in a loss of EPD selectivity and EPD entrapment within the polymer matrix not observed in PAMA MIPFs. MMA, by virtue of its methyl group, is able to provide the scaffolding and rigidity necessary for stability and preservation of imprinted cavities within the PAMA MIPF leading to high EPD selectivity.
Publisher: Elsevier BV
Date: 06-2000
Publisher: Wiley
Date: 16-06-2014
Abstract: CE can efficiently separate poly(3,4-ethylenedioxythiophene) oly(styrene sulfonic acid) (PEDOT/PSS) complexes and free PSS in dispersions and can be used to estimate the degree of PSS doping. We investigated the doping efficiency of PSS on PEDOT in dispersions using CE and its effect on the conductivity of the resulting PEDOT/PSS films. Results of this study indicate that dispersions containing 1:2.5-3 EDOT:PSS feed ratio (by weight) exhibiting 72-73% PSS doping generate highly processable and highly conductive films. Conductivity can be optimized by limiting the time of reaction to 12 h. At this point of the reaction, the PEDOT/PSS segments, appearing as broad band in the electropherogram, could still exist in an extended coil conformation favoring charge transport resulting in high conductivity. Above a threshold PEDOT length formed at reaction times longer than 12 h, the PEDOT/PSS complex, appearing as spikes in the electropherogram, most likely have undergone a conformational change to coiled core-shell structure restricting charge transport resulting in low conductivity. The optimal conductivity (5.2 S/cm) of films from dispersions synthesized for 12 h is significantly higher than those from its commercial equivalent Clevios P and other reported values obtained under similar conditions without the addition of codopants.
Publisher: Elsevier BV
Date: 10-2016
Publisher: CSIRO Publishing
Date: 2005
DOI: 10.1071/CH04138
Abstract: Molecular imprinted polymers (MIPs) have distinctive features that make them attractive as an inexpensive, reusable, and robust field-based detection system for illicit substances. Optimizing MIP performance is traditionally attained by the synthesis and evaluation of a plethora of in idual formulations. A non-covalently imprinted polymer for cocaine has been prepared using a commercially available molecular modelling package (Spartan 02) to predict energetically favourable monomer–template interactions between the target (T) and two different functional monomers (FM)—methacrylic acid (MAA) and 4-vinylpyridine (4VP). NMR studies undertaken to assess target–monomer behaviour in solution were in good agreement with the computational data. MIPs involving three target-to-functional monomer ratios (1 : 2, 1 : 6, and 1 : 14) were prepared and evaluated. Target rebinding was found to be most favourable in the 1 : 2 formulation with a target-selective binding of 0.48 ppm and an imprinting factor (I) of 2.8 obtained for 10 mg of test polymer.
Publisher: IOP Publishing
Date: 06-2019
DOI: 10.1088/1742-6596/1242/1/012007
Abstract: Poly(3,4-ethylene dioxythiophene) (PEDOT) is a highly electronic material. PEDOT is an insoluble polymer, but it can be an aqueous dispersion in polystyrene sulfonate (PSS) solution as the doping agent. Carrageenans are anionic heteropolysaccharide with ester sulphate groups, which are similar functional group contained in PSS. Carrageenan, one of the potentials natural source of Indonesia, are structured of alternating β-d-galactopyranose and 3,6-anhydrogalactose or α-d-galactopyranose. Carrageenans are possible potential as the alternative doping agent for PEDOT to prepare PEDOT/Carr dispersions due to their similarity on –SO 3 - functional group. This study prepared PEDOT/Carr aqueous dispersion in 1:1 ratio by weight as a conductive green polymer. PEDOT/Carr (1:1) dispersion was succesfully synthesized by oxidative polymerisation via in-situ and post-polymerisation reaction. The effect of base solutions or pH is very interesting to investigate on physicochemical of carrageenan doped with PEDOT. Processable conductive PEDOT/Carr dispersion needs to be investigated to optimize the properties of the film.
Publisher: IOP Publishing
Date: 06-2019
DOI: 10.1088/1742-6596/1242/1/012008
Abstract: Structure of poly(3.4-ethylene)dioxythiophene (PEDOT) has been modified by end-capping the chain using a thiophene base monomer. End-capping was carried out to study the effect of PEDOT structures on the conductivity of the PEDOT/PSS films. The monomer used for the end-capping was 2-thienylmethyl methacrylate (2TMM). Endcapping of PEDOT with 2TMM was achieved by oxidative polymerisation of 3.4-ethylenedioxythiophene (EDOT) monomer in the presence of PSS as a dopant in aqueous solvent, and Na 2 S 2 O 8 and Fe 2 (SO 4 ) 3 as oxidation agents. The reactions performed using ratio EDOT:PSS of 1:2.5, with the addition of varying concentrations of end capping agent: 10%, 20%, 30%, 40% and 50% by weight with respect to the EDOT monomer. Chemical characterisations of the structures were analysed using NMR and FTIR. PEDOT/PSS dispersions were also analysed using dynamic light scattering (DLS), capillary electrophoresis (CE), scanning electron microscopy (SEM), and conductivity measurements using the four point probe method. The results showed that the end-capping PEDOT was successfully employed using 2TMM monomer. The higher ratio of end-capping agent resulted in smaller PEDOT as indicated by CE and DLS results. Films surface were smoother with an increase in the ratio of end-capping monomer. While the conductivities of the films decreased with an increase in the ratio of 2TMM monomer.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5AY01673H
Abstract: p K a s of novel biaryl monomers for MIPs designed for aqueous environment were determined by the Yasuda–Shedlovsky method.
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4OB00547C
Abstract: The selectivity and rebinding capacity of molecularly imprinted polymers selective for propranolol ( 1 ) using the room temperature ionic liquids [BMIM][BF 4 ], [BMIM][PF 6 ], [HMIM][PF 6 ] and [OMIM][PF 6 ] and CHCl 3 were examined.
Publisher: Wiley
Date: 10-07-2001
DOI: 10.1002/POLA.1271
Publisher: American Chemical Society (ACS)
Date: 04-12-2014
DOI: 10.1021/IE502564T
Publisher: Bentham Science Publishers Ltd.
Date: 07-03-2016
Publisher: Elsevier BV
Date: 10-2009
Publisher: Wiley
Date: 13-01-2020
DOI: 10.1002/CHIR.23167
Publisher: IEEE
Date: 06-2013
Publisher: MDPI AG
Date: 09-02-2022
DOI: 10.3390/MOLECULES27041162
Abstract: This study demonstrates the feasibility of molecular imprinting using a functional chain transfer agent sans a functional monomer. Ethylene glycol dimethacrylate (EGDMA)-based MIPs were synthesised in the presence of thioglycolic acid (TGA) possessing a carboxylic acid group, capable of interacting with the chosen test template R,S-(±)-propranolol (PNL) and a labile S-H bond to facilitate an efficient chain transfer reaction. Quantitative 1H NMR measurements showed high PNL and TGA incorporation within the MIP, indicating an efficient chain transfer process and a favourable interaction between PNL and TGA. TGA-50, with the lowest amount of CTA, showed the largest imprinting effect and an imprinting factor (IF) of 2.1. The addition of MAA to the formulation improved the binding capacity of PNL to the MIP but also increased NIP binding, resulting in a slightly decreased IF of 1.5. The Kd for the high-affinity sites of the TGA/MAA MIP were found to be two times lower (10 ± 1 μM) than that for the high-affinity sites of the TGA-only MIPs, suggesting that the incorporation of the functional monomer MAA increases the affinity towards the PNL template. Selectivity studies, cross-reactivity as well as binary competitive and displacement assays showed the TGA-based MIPs to be highly selective towards PNL against pindolol and slightly competitive against atenolol. The morphologies of the polymers were shown to be affected by the concentration of the TGA, transforming into discrete macrospheres (from small aggregates) at a higher TGA concentration.
Publisher: Trans Tech Publications, Ltd.
Date: 03-2017
DOI: 10.4028/WWW.SCIENTIFIC.NET/KEM.733.8
Abstract: Polypyrrole (PPy) and manganese (Mn) due their remarkable properties offers a good performance for electrochemical capacitors. Manganese modified polypyrole (Mn-modified PPy) thin films were chrono erometically (CA) deposited on the platinum-titanium crystal resonator as a part of the electrochemical quartz crystal microbalance (EQCM). The performances of the thin films were then examined for performance using cyclic voltammetry (CV). The effects of pyrrole monomer and manganese oxides concentrations were also investigated in this study.
Publisher: American Chemical Society (ACS)
Date: 06-10-2016
Publisher: Bentham Science Publishers Ltd.
Date: 04-2012
Publisher: Elsevier
Date: 2016
Publisher: Elsevier BV
Date: 09-2014
DOI: 10.1016/J.JHAZMAT.2014.07.049
Abstract: In this paper we focus on the development of a methodology for treatment of carbon tetrachloride utilising a non-equilibrium plasma operating at atmospheric pressure, which is not singularly aimed at destroying carbon tetrachloride but rather at converting it to a non-hazardous, potentially valuable commodity. This method encompasses the reaction of carbon tetrachloride and methane, with argon as a carrier gas, in a quartz dielectric barrier discharge reactor. The reaction is performed under non-oxidative conditions. Possible pathways for formation of major products based on experimental results and supported by quantum chemical calculations are outlined in the paper. We elucidate important parameters such as carbon tetrachloride conversion, product distribution, mass balance and characterise the chlorinated polymer formed in the process.
Publisher: Wiley
Date: 21-03-2017
Abstract: Frontal analysis capillary electrophoresis was used to evaluate the binding performance of molecularly imprinted microspheres (MIM) toward its template histamine and analogs at pH 7, and compared to the high performance liquid chromatographic method. In both methods, batch binding was employed and the binding parameters were calculated from the measured concentration of unbound amine analytes and afforded comparable histamine equilibrium dissociation constants (K
Publisher: Royal Society of Chemistry (RSC)
Date: 2006
DOI: 10.1039/B517886J
Abstract: Synthesis of trans-aconitic acid molecularly imprinted polymers in [bmim][BF4] and [bmim][PF6] under photochemical (5 degrees C, AIBN) and thermal (60 degrees C, AIBN) conditions gave polymer micro-spheres (<200 nm), under bulk and precipitation polymerisation conditions, and higher selectivity indices (100% improvement) relative to the more traditional precipitation polymerisation (CH3CN, high solvent volumes) approach.
Publisher: MDPI AG
Date: 07-03-2023
DOI: 10.3390/IJMS24065117
Abstract: Molecularly imprinted polymers (MIPs) for benzylpiperazine (BZP, 1), an illicit designer drug, were developed by using both self-assembly and semi-covalent approaches. From an array of potential functional monomers (FMs) and using a combination of pre-synthetic interaction studies (by molecular modelling and NMR analysis) and binding assays, the highest performing self-assembly 1-MIPs were confirmed to result from methacrylic acid (7) as FM, ethylene glycol dimethacrylate (EGDMA) or trimethylolpropane trimethacrylate (TRIM) as crosslinkers and chloroform as the porogen and rebinding solvent at template (T): FM ratios of 1:1 and 1:2, giving imprinting factors (IF) 3 to 7. The semi-covalent 1-MIPs were designed using benzylpiperazine (4-vinylphenyl) carbamate (16) as the template–monomer adduct in combination with either EDGMA or TRIM. Our comparative analysis showed the semi-covalent polymers to have a stronger affinity for 1 (significantly lower Kd values and higher IFs) and faster uptake than the self-assembly systems. Both approaches have comparable cross-reactivity: marginal to low against cocaine (17) and morphine (18) and high against ephedrine (19) and phenylpiperazine (20). They also have comparable selectivity: highly selective towards 1 against 17, moderate against 18 and non-selective against 19. EGDMA-based self-assembly MIPs displayed a greater imprinting effect (higher IFs and NIP-to-MIP Kd ratios) than TRIM-based MIPs, while the TRIM-based semi-covalent MIP outperformed its EGDMA-based equivalent. By virtue of its modest selectivity against the test illicit drugs, 1-MIPs could potentially be used as a dummy MIP for the broad-based capture and enrichment of illicit drug blends for subsequent laboratory analysis.
Publisher: Elsevier BV
Date: 1999
Publisher: CSIRO Publishing
Date: 2006
DOI: 10.1071/CH05318
Abstract: In the wine industry 2,4,6-trichloroanisole (TCA) has been identified as the primary contaminant responsible for ‘cork taint’. A molecularly imprinted polymer (MIP) selective for TCA was prepared in three porogens (hexane, acetonitrile, and dichloromethane) of varying polarities using non-covalent molecular imprinting techniques. Target rebinding to the MIP was found to be most effective in its porogenic solvent and highest in dichloromethane (imprinting factor = 3.65). Competitive binding assays performed against a range of close structural analogues demonstrated a preference for the target molecule.
Publisher: Elsevier BV
Date: 12-2016
Publisher: IEEE
Date: 06-2013
Publisher: Royal Society of Chemistry (RSC)
Date: 2010
DOI: 10.1039/B9NJ00538B
Publisher: Wiley
Date: 06-2020
Publisher: Wiley
Date: 08-2013
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 10-2014
Publisher: Elsevier BV
Date: 02-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4OB00517A
Abstract: Six novel functional monomers ( M1–M6 ) were examined for their ability to imprint theophylline ( 1 ). The best selectivity was observed with M2 .
Publisher: Elsevier BV
Date: 05-2016
Publisher: Wiley
Date: 10-2012
Publisher: InTech
Date: 22-09-2011
DOI: 10.5772/21725
No related grants have been discovered for Clovia I Holdsworth.