ORCID Profile
0000-0002-7573-0548
Current Organisations
Khwaja Fareed University of Engineering & Information Technology
,
Radboudumc
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Publisher: Elsevier BV
Date: 08-2021
Publisher: Cold Spring Harbor Laboratory
Date: 05-10-2022
DOI: 10.1101/2022.10.04.510897
Abstract: The brain’s anatomy constrains its function, but precisely how remains unclear. Here, we show that human cortical and subcortical activity, measured with magnetic resonance imaging under spontaneous and erse task-evoked conditions, can be parsimoniously understood as resulting from excitations of fundamental, resonant modes of the brain’s geometry (i.e., its shape) rather than modes from complex inter-regional connectivity, as classically assumed. We then use these modes to show that task-evoked activations across ,000 brain maps are not confined to focal areas, as widely believed, but instead excite brain-wide modes with wavelengths spanning mm. Finally, we confirm theoretical predictions that the close link between geometry and function is explained by a dominant role for wave-like dynamics, showing that such dynamics can reproduce numerous canonical spatiotemporal properties of spontaneous and evoked recordings. Our findings challenge prevailing views of brain function and identify a previously under-appreciated role of brain geometry that is predicted by a unifying and physically principled approach.
Publisher: Cold Spring Harbor Laboratory
Date: 09-10-2023
Publisher: Springer Science and Business Media LLC
Date: 18-04-2023
DOI: 10.1038/S41398-023-02417-2
Abstract: Both psychotic illness and subclinical psychosis-like experiences (PLEs) have been associated with cortico-striatal dysfunction. This work has largely relied on a discrete parcellation of the striatum into distinct functional areas, but recent evidence suggests that the striatum comprises multiple overlapping and smoothly varying gradients (i.e., modes) of functional organization. Here, we investigated two of these functional connectivity modes, previously associated with variations in the topographic patterning of cortico-striatal connectivity (first-order gradient), and dopaminergic innervation of the striatum (second-order gradient), and assessed continuities in striatal function from subclinical to clinical domains. We applied connectopic mapping to resting-state fMRI data to obtain the first-order and second-order striatal connectivity modes in two distinct s les: (1) 56 antipsychotic-free patients (26 females) with first-episode psychosis (FEP) and 27 healthy controls (17 females) and (2) a community-based cohort of 377 healthy in iduals (213 females) comprehensively assessed for subclinical PLEs and schizotypy. The first-order “cortico-striatal” and second-order “dopaminergic” connectivity gradients were significantly different in FEP patients compared to controls bilaterally. In the independent s le of healthy in iduals, variations in the left first-order “cortico-striatal” connectivity gradient were associated with inter-in idual differences in a factor capturing general schizotypy and PLE severity. The presumed cortico-striatal connectivity gradient was implicated in both subclinical and clinical cohorts, suggesting that variations in its organization may represent a neurobiological trait marker across the psychosis continuum. Disruption of the presumed dopaminergic gradient was only noticeable in patients, suggesting that neurotransmitter dysfunction may be more apparent to clinical illness.
Location: Pakistan
No related grants have been discovered for Marianne Oldehinkel.