ORCID Profile
0000-0002-6490-889X
Current Organisations
Organisation
,
University of Wollongong
,
State University of Campinas
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In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Civil Engineering | Composite and Hybrid Materials | Civil Geotechnical Engineering | Construction Engineering | Infrastructure Engineering and Asset Management | Structural Engineering | Construction Materials
Primary Mining and Extraction of Mineral Resources not elsewhere classified | Cement and Concrete Materials | Coal Mining and Extraction | Metals (e.g. Composites, Coatings, Bonding) | Civil Construction Planning |
Publisher: Springer New York
Date: 2013
Publisher: Elsevier BV
Date: 10-2014
Publisher: Elsevier BV
Date: 05-2023
Publisher: Springer International Publishing
Date: 27-09-2022
Publisher: American Society of Civil Engineers (ASCE)
Date: 12-2012
Publisher: Thomas Telford Ltd.
Date: 06-2005
Publisher: Civil-Comp Press
Date: 2005
DOI: 10.4203/CCP.81.175
Publisher: Elsevier BV
Date: 05-2020
Publisher: American Society of Civil Engineers (ASCE)
Date: 07-2012
Publisher: American Society of Civil Engineers (ASCE)
Date: 06-2023
Publisher: World Scientific Pub Co Pte Ltd
Date: 04-2013
DOI: 10.1142/S0219455412500654
Abstract: This paper presents a new numerical model for the nonlinear analysis of circular concrete-filled steel tubular (CFST) slender beam-columns with preload effects, in which the initial geometric imperfections, deflections caused by preloads, concrete confinement and second order effects are incorporated. Computational algorithms are developed to solve the nonlinear equilibrium equations. Comparative studies are undertaken to validate the accuracy of computational algorithms developed. Also included is a parametric study for examining the effects of the preloads, column slenderness, diameter-to-thickness ratio, loading eccentricity, steel yield stress and concrete confinement on the behavior of circular CFST slender beam-columns under eccentric loadings. The numerical model is demonstrated to be capable of predicting accurately the behavior of circular CFST slender beam-columns with preloads. The preloads on the steel tubes can affect significantly the behavior of CFST slender beam-columns and must be taken into account in the design.
Publisher: American Society of Civil Engineers (ASCE)
Date: 02-2014
Publisher: Elsevier BV
Date: 08-2012
Publisher: Elsevier BV
Date: 04-2023
Publisher: Springer Nature Singapore
Date: 21-09-2022
Publisher: ISEC Press
Date: 05-2016
DOI: 10.14455/ISEC.RES.2016.56
Abstract: High strength concrete has higher strength but lower ductility. Inclusion of single type of fibers into concrete has been proven to improve the behavior of concrete to a limited extent. However, recently it was found that the behavior of concrete can be improved more with the addition of hybrid fiber i.e., a combination of different types of fiber. This paper presents the results of an experimental investigation on the behavior of Hybrid Steel Fibre Reinforced High Strength Concrete (HSFR-HSC). A total of eight cylinder specimens with 150 mm in diameter and 300 mm in height were cast and tested under uniaxial compression. Three different combinations of HSFR-HSC specimens and reference specimens without steel fibers were prepared. The first combination of HSFR-HSC included 1.5% Micro Steel (MS) fibers and 1% Deformed Steel (DS) fibers. The second combination included 1.5% MS fibers and 1.5% Hooked-end Steel (HS) fibers. The third combination included 1% DS fibers and 1.5% HS fibers. The experimental results showed that the addition of hybrid steel fibers improved the strength and ductility of high strength concrete compared to the reference specimens. The results also showed that the specimens reinforced with different hybrid steel fibers failed in a ductile manner, while the reference specimens failed in a brittle manner.
Publisher: Springer Science and Business Media LLC
Date: 10-07-2019
Publisher: Elsevier BV
Date: 05-2018
Publisher: American Society of Civil Engineers
Date: 30-04-2013
Publisher: Springer Science and Business Media LLC
Date: 06-01-2015
Publisher: Civil-Comp Press
Date: 2011
DOI: 10.4203/CCP.96.63
Publisher: Elsevier BV
Date: 08-2021
Publisher: Elsevier BV
Date: 04-2020
Publisher: American Society of Civil Engineers (ASCE)
Date: 04-2022
Publisher: Elsevier BV
Date: 2023
Publisher: Editora de Livros IABS
Date: 2018
Publisher: ASTM International
Date: 09-09-2017
DOI: 10.1520/JTE20150525
Publisher: Inderscience Publishers
Date: 2003
Publisher: Elsevier BV
Date: 10-2003
Publisher: Springer Science and Business Media LLC
Date: 05-2019
Publisher: Springer International Publishing
Date: 27-09-2022
Publisher: Elsevier BV
Date: 2007
Publisher: Elsevier BV
Date: 12-2021
Publisher: Elsevier BV
Date: 07-2017
Publisher: World Scientific Publishing Company
Date: 06-2003
Publisher: American Concrete Institute
Date: 2022
DOI: 10.14359/51732986
Publisher: Elsevier BV
Date: 11-1995
Publisher: Wiley
Date: 25-11-2022
Abstract: This paper presents the results of an experimental investigation on the behavior of glass fiber reinforced polymer (GFRP) bar‐reinforced hollow‐core (GFRP‐HC) circular concrete specimens under concentric, 25 mm and 50 mm eccentric axial loading and four‐point bending. The main parameters investigated include the type of reinforcing bars, pitch of the helices and loading conditions. The test matrix of this study consists of 12 specimens, among which nine specimens (850 mm high) were tested under concentric and eccentric axial loading and the remaining three specimens (1500 mm long) were tested under four‐point bending. The specimens were circular in cross‐section with an outer diameter of 214 mm and an inner circular hole diameter of 56 mm. The experimental results showed that, for the similar amount of reinforcement, steel bar‐reinforced hollow‐core (steel‐HC) specimens sustained higher loads than the GFRP‐HC specimens under different loading conditions. Also, the steel‐HC specimens achieved higher ductility than the GFRP‐HC specimens under 50 mm eccentric axial loading and four‐point bending. However, under concentric and 25 mm eccentric axial loading, the GFRP‐HC specimens achieved higher ductility than the steel‐HC specimens. The close pitch of the GFRP helices significantly enhanced the load carrying capacity and ductility of the GFRP‐HC specimens.
Publisher: Elsevier BV
Date: 04-2020
Publisher: BMJ
Date: 03-07-2020
Abstract: Climate change is an emerging and growing field of practice for the international public health community. As practitioners, researchers and policy-makers grapple with the local health impacts of climate change, there is an increasing need to clarify key terminology to support public health actors engage and respond in ways that promote intersectoral collaboration. This contribution introduces the public health discourse on climate change, with a particular focus on its implications for health equity. After defining key terms and existing adaptation practices, climate justice and assets-oriented inquiry into the intersectional determinants of health are discussed as future opportunities for addressing health equity in climate and health-related research and practice.
Publisher: American Society of Hematology
Date: 22-12-2011
DOI: 10.1182/BLOOD-2011-06-362533
Abstract: SCID resulting from mutations in IL2RG or JAK3 is characterized by lack of T and natural killer cells B cells are present in normal number, but antibody responses are defective. Hematopoietic cell transplantation (HCT) is curative for SCID. However, B-cell dysfunction persists in a substantial proportion of patients. We hypothesized that impaired B-cell responses after HCT in IL2RG/JAK3 deficiency results from poor donor B-cell engraftment and defective γc-dependent cytokine signaling in host B cells. To test this, and to identify which γc cytokine(s) is critical for humoral immunity, we studied 28 transplanted patients with IL2RG/JAK3 deficiency. Lack of donor B-cell engraftment associated with persistent humoral dysfunction and significantly reduced memory B cells. B-cell proliferation induced by CD40L alone or together with CpG, anti-Ig, IL-4, IL-10, or IL-13 was comparable in healthy controls and in post-HCT SCID patients, irrespective of their chimerism status. However, in vitro stimulation with CD40L/IL-21 induced B-cell proliferation, plasmablast differentiation, and antibody secretion in patients with donor B cells, but not in patients with autologous B cells. These data imply that IL-21–mediated signaling is critical for long-lived humoral immunity and to restore antibody responses in IL2RG/JAK3-deficient patients after HCT. Furthermore, in vitro stimulation with CD40L/IL-21 can predict in vivo B-cell immunity in IL2RG/JAK3 SCID after transplantation.
Publisher: American Society of Civil Engineers (ASCE)
Date: 12-2018
Publisher: Wiley
Date: 06-12-2012
Publisher: Elsevier BV
Date: 09-2004
Publisher: Thomas Telford Ltd.
Date: 07-12-2020
Publisher: American Society of Civil Engineers (ASCE)
Date: 06-2017
Publisher: Elsevier BV
Date: 05-2018
Publisher: Elsevier BV
Date: 11-2018
Publisher: ISEC Press
Date: 05-2016
DOI: 10.14455/ISEC.RES.2016.83
Abstract: The strength and ductility of high strength concrete columns improve with the addition of steel fiber. This paper reports the behavior of circular High Strength Concrete (HSC) columns reinforced with Hybrid Steel Fibers (HSF) under different loading conditions. In this study, HSF consisted of a combination of macro steel fibers and micro steel fibers. A total of eight circular specimens of 205 mm diameter and 800 mm height were cast and tested. All specimens were reinforced with same amount of steel reinforcements. The specimens were ided into two groups of four specimens. Group RC (reference group) contained no steel fibers. Group HSF (hybrid steel fibers) contained 2.5% by volume of HSF. From each group one specimen was tested under concentric loading, one under 25 mm eccentric loading, one under 50 mm eccentric loading, and one under four-point loading. The results showed that the specimens reinforced with HSF achieved higher strength and ductility compared to RC specimens under different loading conditions. It was also observed that the presence of HSF delayed the spalling of the concrete cover.
Publisher: Elsevier BV
Date: 12-2019
Publisher: Elsevier BV
Date: 04-2022
Publisher: Elsevier BV
Date: 10-2014
Publisher: Elsevier BV
Date: 11-2017
Publisher: Wiley
Date: 20-11-2022
Abstract: This study investigated the feasibility of using two types of waste glass sand as fine aggregate replacement in ambient cured alkali‐activated mortars (AAMs). Fly ash (FA) and ground granulated blast furnace slag were used as aluminosilicate source materials to produce the AAMs. The waste glass sand was used to replace 0%, 25%, 50%, 75%, and 100% fine aggregate (by mass) in AAMs. The influences of the use of waste glass sand, for the replacement of fine aggregate, on slump flow, setting time, compressive strength, and flexural strength of ambient cured AAMs were evaluated. It was found that the slump flow and setting time of ambient cured AAMs significantly increased as the percentage of replacement of fine aggregate by waste glass sand increased. However, the compressive and flexural strengths of ambient cured AAMs decreased when 50% and over fine aggregate were replaced by waste glass sand. The ambient cured AAMs with 25% replacement of fine aggregate with waste glass sand achieved the highest compressive and flexural strengths. Scanning electron microscope analysis indicated that the increase in the compressive strength and flexural strength of AAMs was due to the bridging‐like effect and filling effect provided by the waste glass sand. The use of waste glass sand as a partial replacement of fine aggregate in ambient cured AAMs was found to be feasible. In addition, 25% of the fine aggregate replaced by waste glass sand resulted in the best mechanical properties for ambient cured AAMs.
Publisher: Elsevier BV
Date: 2023
Publisher: Elsevier BV
Date: 2019
Publisher: Wiley
Date: 10-12-2010
Publisher: World Scientific Publishing Company
Date: 06-2003
Publisher: Elsevier BV
Date: 07-2006
Publisher: Thomas Telford Ltd.
Date: 08-2018
Abstract: This study explores the effect of length to diameter (L/D) ratio on the axial load capacity of small-diameter self-compacting concrete-filled steel tube (SCFT) specimens. The SCFT specimens with L/D ratio of 2 to 14 were tested. Two different cold-formed steel tubes with diameters of 26·9 and 33·7 mm were used in the construction of the SCFT specimens. The behaviour of the SCFT specimens was compared with the unfilled steel tube (UT) specimens. The axial load capacity of SCFT specimens was found to be higher than the axial load capacity of UT specimens. The compressive failure of SCFT and UT specimens with a ratio of 2 and 4 occurred due to local buckling, and with L/D ratio ≥ 6 failure occurred due to global buckling. However, the self-compacting concrete inside the steel tubes improved the ductility and the post-peak axial load–axial deformation response of SCFT specimens compared to the UT specimens.
Publisher: Wiley
Date: 21-09-2023
Publisher: Informa UK Limited
Date: 02-10-2017
Publisher: American Society of Civil Engineers (ASCE)
Date: 12-2021
Publisher: Civil-Comp Press
Date: 2001
DOI: 10.4203/CCP.73.74
Publisher: Bentham Science Publishers Ltd.
Date: 30-10-2008
Publisher: American Society of Civil Engineers (ASCE)
Date: 06-2017
Publisher: Informa UK Limited
Date: 2005
Publisher: Thomas Telford Ltd.
Date: 04-2019
Abstract: This study presents an experimental evaluation of three different methods for determining the tensile strength of steel fibre reinforced concrete (SFRC). The test methods include the splitting test (ST), double punch test (DPT) and direct tensile test (DTT). The compressive strength of the concrete used in this study ranged between 30 and 80 MPa with 0%, 1·5% and 3% steel fibre by volume of the concrete. In total, 81 concrete cylinders were cast and tested for 28-d compressive strength, splitting tensile strength and double punch tensile strength of the concrete. In addition, 27 concrete prism specimens were cast and tested to determine the direct tensile strength of the concrete. The test results show that, compared to the ST, the DPT is more effective in predicting the tensile strength of SFRC, as the tensile strengths obtained from the DPT and the direct tensile test are very close. The DPT is easier to perform and costs less than the ST and the DTT.
Publisher: Wiley
Date: 08-02-2023
Abstract: In this paper, low‐strength polyvinyl alcohol (L‐PVA) fibers, high‐strength polyvinyl alcohol (H‐PVA) fibers, and polyethylene (PE) fibers were used to prepare ambient cured fly ash‐slag‐based engineered geopolymer composites (EGC). The effects of fiber types and fiber volume fractions (1.5%, 1.75%, 2.0%, 2.25%, and 2.5%) on the compressive strength and tensile performance of EGC were evaluated. It was found that by increasing the fiber volume fraction from 1.5% to 2.5%, L‐PVA fibers had the lowest influence, whereas PE fibers had the highest influence on the compressive strength of EGC. The optimum fiber volume fractions of L‐PVA, H‐PVA, and PE fibers were 1.75%, 2.25%, and 1.5%, respectively, for EGC to achieve the best tensile performance. Scanning electron microscope (SEM) investigations showed that the bonding performance of PE fibers to the EGC matrix was higher than those of L‐PVA and H‐PVA fibers to the EGC matrix.
Publisher: American Society of Civil Engineers
Date: 04-08-2000
Publisher: American Society of Civil Engineers (ASCE)
Date: 05-2018
Publisher: Elsevier BV
Date: 2021
DOI: 10.2139/SSRN.3973730
Publisher: Elsevier BV
Date: 09-2018
Publisher: Elsevier BV
Date: 11-2021
Publisher: Springer Science and Business Media LLC
Date: 02-02-2021
Publisher: American Society of Civil Engineers (ASCE)
Date: 06-2020
Publisher: Wiley
Date: 27-11-2019
Publisher: American Society of Hematology
Date: 05-12-2013
DOI: 10.1182/BLOOD-2013-06-506865
Abstract: IL21-mediated induction of CD25 expression on naïve human B cells requires STAT3. A lack of response to IL-2 may lify humoral immunodeficiency in patients with STAT3, IL2RG, or IL21R mutations due to unresponsiveness to IL21.
Publisher: Elsevier BV
Date: 02-2009
Publisher: Editora de Livros IABS
Date: 30-04-2018
DOI: 10.18472/SUSTDEB.V9N1.2018.28258
Abstract: As mudanças ambientais antrópicas despertaram a atenção para a importância dos ecossistemas como fundamentais para sustentar a saúde e o bem-estar humanos. Várias escolas de pensamento e c os de atuação em pesquisa e ação buscam compreender a saúde e os fenômenos sociais e ecológicos associados. Apresentamos 18 desses c os de atuação destacando seus elementos comuns e ergências. Eles convergem em torno do cruzamento de fronteiras disciplinares e na aplicação do pensamento sistêmico, enquanto as principais diferenças são encontradas nas metodologias, nos enfoques de pesquisa e no enquadramento dos problemas. Embora os c os busquem promover a saúde pelos caminhos sustentáveis e equitativos, as abordagens despolitizadas e a-históricas continuam sendo parte da prática padrão. Pesquisas futuras requerem um compromisso maior na avaliação das nossas próprias condutas como atores políticos e na promoção de novos espaços de discussões sobre a dinâmica de poder, a fim de (re)centralizar os participantes nas metodologias de pesquisa.
Publisher: World Scientific Pub Co Pte Lt
Date: 08-2019
DOI: 10.1142/S0219455419500858
Abstract: A mathematical model using the fiber approach is presented in this paper for quantifying the strength and fire-resistance of eccentrically loaded slender concrete-filled steel tubular (CFST) columns with rectangular sections incorporating the interaction of local and global buckling. The model utilizes the thermal simulator to ascertain the temperature distribution in cross-sections, and the nonlinear global buckling analysis to predict the interaction responses of local and global buckling of loaded CFST slender columns to fire effects. The initial geometric imperfection, air gap between the concrete and steel tube, tensile concrete strength, deformations caused by preloads, and temperature-dependent material behavior are included in the formulation. The computational theory, modeling procedure and numerical solution algorithms are described. The computational model is verified by existing experimental and numerical results. The structural responses and fire-resistance of CFST columns of rectangular sections exposed to fire are investigated. The mathematical model proposed is demonstrated to be an efficient computer simulator for the fire-performance of slender CFST columns loaded eccentrically.
Publisher: Springer Science and Business Media LLC
Date: 19-09-2018
Publisher: Elsevier BV
Date: 10-2021
Publisher: Rockefeller University Press
Date: 16-12-2019
DOI: 10.1084/JEM.20191336
Abstract: Antibody-mediated autoimmune diseases are a major health burden. However, our understanding of how self-reactive B cells escape self-tolerance checkpoints to secrete pathogenic autoantibodies remains incomplete. Here, we demonstrate that patients with monogenic immune dysregulation caused by gain-of-function mutations in PIK3CD, encoding the p110δ catalytic subunit of phosphoinositide 3-kinase (PI3K), have highly penetrant secretion of autoreactive IgM antibodies. In mice with the corresponding heterozygous Pik3cd activating mutation, self-reactive B cells exhibit a cell-autonomous subversion of their response to self-antigen: instead of becoming tolerized and repressed from secreting autoantibody, Pik3cd gain-of-function B cells are activated by self-antigen to form plasmablasts that secrete high titers of germline-encoded IgM autoantibody and hypermutating germinal center B cells. However, within the germinal center, peripheral tolerance was still enforced, and there was selection against B cells with high affinity for self-antigen. These data show that the strength of PI3K signaling is a key regulator of pregerminal center B cell self-tolerance and thus represents a druggable pathway to treat antibody-mediated autoimmunity.
Publisher: Thomas Telford Ltd.
Date: 04-2005
Publisher: Bulletin of Chemical Reaction Engineering and Catalysis
Date: 29-07-2018
DOI: 10.9767/BCREC.13.3.2570.543-552
Abstract: In this paper, three different kinds of aluminum sources (sodium aluminate, aluminum sulfate and aluminum isopropylate) were used for preparing of nano beta-zeolite. The as synthesized zeolites were mixed with the as prepared amorphous silica-alumina to produce the supports for hydrocracking catalyst. The prepared supports were used for preparation of NiMo/silica alumina-nano beta-zeolite by impregnation method. The influence of the aluminum source for preparation of beta-zeolite on the performance of the prepared catalysts has been studied. The s les were thoroughly characterized by X-Ray diffraction method (XRD), field emission-scanning electron microscopy (FE-SEM), N2 adsorption-desorption isotherms (BET), temperature programmed desorption (TPD) and temperature programmed reduction (TPR) methods. The catalysts performance was evaluated by vacuum gas oil (VGO) hydrocracking at 390 oC in a fixed bed reactor. The XRD patterns showed that the beta-zeolite s les obtained from the present methods were pure and highly crystalline and the crystal size of the prepared zeolites were in nanometer scale. Crystallite size of nano beta-zeolite synthesized by aluminum isopropylate [Al(iPrO)3] was smaller than those of prepared by the other aluminum sources. The catalyst containing this zeolite with higher surface area (231 m2/g) and more available acid sites (1.66 mmol NH3/g) possessed higher activity and selectivity to gas oil (71.9 %).
Publisher: Editora de Livros IABS
Date: 30-04-2018
DOI: 10.18472/SUSTDEB.V9N1.2018.28258
Abstract: As mudanças ambientais antrópicas despertaram a atenção para a importância dos ecossistemas como fundamentais para sustentar a saúde e o bem-estar humanos. Várias escolas de pensamento e c os de atuação em pesquisa e ação buscam compreender a saúde e os fenômenos sociais e ecológicos associados. Apresentamos 18 desses c os de atuação destacando seus elementos comuns e ergências. Eles convergem em torno do cruzamento de fronteiras disciplinares e na aplicação do pensamento sistêmico, enquanto as principais diferenças são encontradas nas metodologias, nos enfoques de pesquisa e no enquadramento dos problemas. Embora os c os busquem promover a saúde pelos caminhos sustentáveis e equitativos, as abordagens despolitizadas e a-históricas continuam sendo parte da prática padrão. Pesquisas futuras requerem um compromisso maior na avaliação das nossas próprias condutas como atores políticos e na promoção de novos espaços de discussões sobre a dinâmica de poder, a fim de (re)centralizar os participantes nas metodologias de pesquisa.
Publisher: Elsevier BV
Date: 10-2015
Publisher: Elsevier BV
Date: 06-2016
Publisher: Elsevier BV
Date: 12-2019
Publisher: Civil-Comp Press
Date: 2002
DOI: 10.4203/CCP.75.4
Publisher: Elsevier BV
Date: 03-2020
Publisher: Oxford University Press (OUP)
Date: 13-05-2009
DOI: 10.1111/J.1365-2249.2009.03973.X
Abstract: Common variable immunodeficiency (CVID) is a B cell immunodeficiency disorder characterized frequently by failure of memory B cell development and antibody secretion. A unifying cellular pathogenesis for CVID has not been forthcoming, but given the immunoregulatory role of invariant NK (iNK) T cells and their absence in several other immunodeficiencies, we quantified these cells in the blood of 58 CVID patients. There was a marked decrease in the proportion of iNK T cells in CVID patients compared with controls. This was particularly notable in those with low isotype-switched memory B cells, but subset analysis demonstrated no difference when stratified by specific clinical features. We propose that the decreased proportion of iNK T cells in CVID might be linked to the failure of memory B cell generation, which may contribute to reduced antibody production in these patients.
Publisher: Elsevier BV
Date: 06-2016
Publisher: Elsevier BV
Date: 08-2015
Publisher: Civil-Comp Press
Date: 2003
DOI: 10.4203/CCP.78.37
Publisher: Elsevier BV
Date: 11-2022
Publisher: IOP Publishing
Date: 03-2018
Publisher: Informa UK Limited
Date: 20-03-2015
Publisher: Elsevier BV
Date: 04-2006
DOI: 10.1016/J.JACI.2006.01.004
Abstract: Mutations of the gene encoding the TNF receptor family member transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI), TNFSRF13B, have recently been described in patients with common variable immunodeficiency (CVID). We report the case of a man with CVID in association with a heterozygous TACI gene mutation (C104R) who had a highly unusual, invasive, polyclonal CD8+ T-cell lymphoproliferation resulting in massive hepatosplenomegaly and causing renal impairment because of infiltration. Although lymphoproliferation is well described in CVID, the key features in this patient included the T-cell origin of the lymphoproliferation, its polyclonal nature, its infiltration into multiple organs, and the presence of the TACI gene mutation.
Publisher: Elsevier BV
Date: 02-2021
Publisher: Elsevier BV
Date: 02-2011
Publisher: Elsevier BV
Date: 05-2006
Publisher: Elsevier BV
Date: 10-2019
Publisher: Elsevier BV
Date: 12-2013
Publisher: Civil-Comp Press
Date: 2013
DOI: 10.4203/CCP.102.124
Publisher: Elsevier BV
Date: 2014
Publisher: Informa UK Limited
Date: 08-10-2015
Publisher: Wiley
Date: 15-09-2010
Publisher: CRC Press
Date: 20-06-2008
Publisher: Rockefeller University Press
Date: 11-11-2013
DOI: 10.1084/JEM.20130323
Abstract: Long-lived antibody memory is mediated by the combined effects of long-lived plasma cells (PCs) and memory B cells generated in response to T cell–dependent antigens (Ags). IL-10 and IL-21 can activate multiple signaling pathways, including STAT1, STAT3, and STAT5 ERK PI3K/Akt, and potently promote human B cell differentiation. We previously showed that loss-of-function mutations in STAT3, but not STAT1, abrogate IL-10– and IL-21–mediated differentiation of human naive B cells into plasmablasts. We report here that, in contrast to naive B cells, STAT3-deficient memory B cells responded to these STAT3-activating cytokines, differentiating into plasmablasts and secreting high levels of IgM, IgG, and IgA, as well as Ag-specific IgG. This was associated with the induction of the molecular machinery necessary for PC formation. Mutations in IL21R, however, abolished IL-21–induced responses of both naive and memory human B cells and compromised memory B cell formation in vivo. These findings reveal a key role for IL-21R/STAT3 signaling in regulating human B cell function. Furthermore, our results indicate that the threshold of STAT3 activation required for differentiation is lower in memory compared with naive B cells, thereby identifying an intrinsic difference in the mechanism underlying differentiation of naive versus memory B cells.
Publisher: American Society of Civil Engineers (ASCE)
Date: 10-2016
Publisher: Inderscience Publishers
Date: 2005
Publisher: Elsevier BV
Date: 10-2020
Publisher: Elsevier BV
Date: 09-2023
Publisher: American Concrete Institute
Date: 2020
DOI: 10.14359/51720206
Publisher: CSIRO Publishing
Date: 2012
DOI: 10.1071/HE12003
Publisher: School of Civil Engineering, The University of Queensland
Date: 2015
Publisher: Elsevier BV
Date: 06-2019
Publisher: Elsevier BV
Date: 2016
Publisher: Elsevier BV
Date: 09-2022
Publisher: Elsevier BV
Date: 05-2008
Publisher: SAGE Publications
Date: 04-12-2018
Abstract: Numerous research studies experimentally investigated the axial compressive behavior of fiber-reinforced polymer tube confined concrete cylinders in the past two decades. However, only a limited number of research studies developed stress–strain models to predict the strength and strain enhancement ratio of fiber-reinforced polymer tube confined concrete cylinders under axial compression. The available strength and strain enhancement ratio models of fiber-reinforced polymer tube confined concrete cylinders are a function of actual confinement ratio only. This study develops strength and strain enhancement ratio models for circular fiber-reinforced polymer tube confined concrete under axial compression based on artificial neural network analyses using Purelin and Tansig transfer functions. The developed strength and strain enhancement ratio models are functions of actual confinement ratio, orientation of fibers, height to diameter ratio, and axial strain in unconfined concrete at peak axial stress. The formulation and performance evaluation of the developed strength and strain enhancement ratio models are carried out using experimental investigation results of 238 circular fiber-reinforced polymer tube confined concrete under concentric axial compression compiled from a database of 599 fiber-reinforced polymer tube confined concrete specimens. The predictions of the developed strength and strain enhancement ratio models match well with the experimental investigation results of the compiled database. The developed strength and strain enhancement ratio models exhibit smaller statistical errors than the available models in the research studies for predicting the strength and strain enhancement ratios of circular fiber-reinforced polymer tube confined concrete under axial compression.
Publisher: Elsevier BV
Date: 09-2019
Publisher: Springer New York
Date: 2012
Publisher: American Society of Civil Engineers (ASCE)
Date: 04-2013
Publisher: Springer New York
Date: 2012
Publisher: Elsevier BV
Date: 10-2019
Publisher: Elsevier BV
Date: 03-2005
Publisher: Elsevier BV
Date: 10-2019
Publisher: Thomas Telford Ltd.
Date: 08-2022
Abstract: Cross-sectional analyses of circular and square reinforced concrete (RC) columns strengthened with reactive powder concrete jacketing and fibre-reinforced polymer (FRP) wrapping were undertaken. The stress block method was used to determine theoretical axial load–bending moment (AL–BM) interactions of the columns. These were then compared with experimental results and found to be in very good agreement. A parametric study was also undertaken to investigate the most important factors that influence the AL–BM capacity of circular and square strengthened columns. Finally, a group of theoretical AL–BM interactions for circular and square strengthened columns was produced. These can be used in a wide range of applications for strengthening RC columns with high-performance concrete jackets and FRP wraps.
Publisher: American Society of Civil Engineers (ASCE)
Date: 12-2015
Publisher: Elsevier BV
Date: 03-2015
Publisher: Wiley
Date: 02-01-2021
Abstract: In this study, the behavior of axially loaded plain and fiber‐reinforced geopolymer concrete columns reinforced with glass fiber‐reinforced polymer (GFRP) bars and helices was investigated. Ten ambient‐cured geopolymer concrete columns of 160 mm diameter and 640 mm height were cast and tested under concentric axial loads. The behavior of the columns was investigated under the effect of the type of reinforcement (steel vs. GFRP), pitch of the GFRP helices (40, 75, 100 mm), and addition of nonmetallic fibers, that is, glass fiber and polypropylene fiber. It was found that GFRP bar reinforced geopolymer concrete column achieved less axial load, confinement efficiency, and ductility compared to the geopolymer concrete column reinforced with the same amount of the steel reinforcement. Overall, the reduction in the pitch of the GFRP helices enhanced the confinement efficiency, post‐peak behavior, and ductility of the plain and fiber‐reinforced geopolymer concrete columns. Also, the addition of fibers significantly improved the ductility of the GFRP bar reinforced geopolymer concrete columns.
Publisher: Elsevier BV
Date: 03-2012
Publisher: Elsevier BV
Date: 08-2018
Publisher: Elsevier BV
Date: 06-2018
Publisher: American Concrete Institute
Date: 09-2018
DOI: 10.14359/51702445
Publisher: Elsevier
Date: 2013
Publisher: Civil-Comp Press
Date: 1999
DOI: 10.4203/CCP.60.1.6
Publisher: Rockefeller University Press
Date: 17-07-2018
DOI: 10.1084/JEM.20180010
Abstract: Gain-of-function (GOF) mutations in PIK3CD, encoding the p110δ subunit of phosphatidylinositide 3-kinase (PI3K), cause a primary immunodeficiency. Affected in iduals display impaired humoral immune responses following infection or immunization. To establish mechanisms underlying these immune defects, we studied a large cohort of patients with PIK3CD GOF mutations and established a novel mouse model using CRISPR/Cas9-mediated gene editing to introduce a common pathogenic mutation in Pik3cd. In both species, hyperactive PI3K severely affected B cell development and differentiation in the bone marrow and the periphery. Furthermore, PI3K GOF B cells exhibited intrinsic defects in class-switch recombination (CSR) due to impaired induction of activation-induced cytidine deaminase (AID) and failure to acquire a plasmablast gene signature and phenotype. Importantly, defects in CSR, AID expression, and Ig secretion were restored by leniolisib, a specific p110δ inhibitor. Our findings reveal key roles for balanced PI3K signaling in B cell development and long-lived humoral immunity and memory and establish the validity of treating affected in iduals with p110δ inhibitors.
Publisher: CRC Press
Date: 07-12-2018
Publisher: WORLD SCIENTIFIC
Date: 02-2002
Publisher: Springer Science and Business Media LLC
Date: 27-11-2015
Publisher: Informa UK Limited
Date: 15-12-2022
Publisher: WORLD SCIENTIFIC
Date: 02-2002
Publisher: Oxford University Press (OUP)
Date: 18-02-2009
DOI: 10.1111/J.1365-2249.2009.03913.X
Abstract: Common variable immunodeficiencies (CVID) are a heterogeneous group of antibody deficiency disorders complicated by autoimmune, lymphoproliferative and/or granulomatous manifestations, suggesting variations in immunoregulation. We sought to quantify regulatory CD4 T cells (Treg cells) in the blood of CVID patients and to correlate the frequency with clinical manifestations and classification subgroups. Blood s les from 99 CVID patients in Freiburg, London and Sydney, who had been phenotyped clinically and stratified according to their memory B cell phenotype (Freiburg and Paris classification schemes), were analysed for the proportion of Treg cells, defined either as CD25+/forkhead box P3 (FoxP3)+, CD25+/CD127low/FoxP3+ or CD25+/CD127low CD4+ T cells, and results compared with 49 healthy controls. Irrespective of the phenotype used to define them, there was a significant decrease in the Treg cell proportion in patients with granulomatous disease and immune cytopenias. This allowed the definition of a subgroup of CVID patients with abnormally low Treg cells, which had a higher rate of these two manifestations as well as autoimmune disease in general. There was also a significant reduction in the proportion of Treg cells in the Freiburg group Ia compared with other CVID patients and controls, but there were no differences between the Paris groups. The reduction in Treg cells in subsets of CVID patients may be relevant to their clinical manifestations, and may contribute to our understanding of the pathogenesis of CVID complications.
Publisher: Elsevier BV
Date: 06-2018
Publisher: Elsevier BV
Date: 04-2018
Publisher: Wiley
Date: 12-07-2021
DOI: 10.1111/AJD.13659
Publisher: Springer New York
Date: 2013
Publisher: American Society of Civil Engineers (ASCE)
Date: 12-2012
Publisher: American Society of Civil Engineers (ASCE)
Date: 08-2017
Publisher: Elsevier BV
Date: 11-2020
Publisher: Thomas Telford Publishing
Date: 2005
Publisher: Elsevier BV
Date: 03-2012
Publisher: Elsevier BV
Date: 06-2007
Publisher: American Society of Civil Engineers (ASCE)
Date: 12-2020
Publisher: Elsevier BV
Date: 06-2019
Publisher: Elsevier BV
Date: 07-2017
Publisher: Elsevier BV
Date: 2019
DOI: 10.1016/J.JACI.2018.04.030
Abstract: Germline gain-of function (GOF) mutations in PIK3CD, encoding the catalytic p110δ subunit of phosphoinositide 3-kinase (PI3K), result in hyperactivation of the PI3K-AKT-mechanistic target of rapamycin pathway and underlie a novel inborn error of immunity. Affected subjects exhibit perturbed humoral and cellular immunity, manifesting as recurrent infections, autoimmunity, hepatosplenomegaly, uncontrolled EBV and/or cytomegalovirus infection, and increased incidence of B-cell lymphoproliferation, lymphoma, or both. Mechanisms underlying disease pathogenesis remain unknown. Understanding the cellular and molecular mechanisms underpinning inefficient surveillance of EBV-infected B cells is required to understand disease in patients with PIK3CD GOF mutations, identify key molecules required for cell-mediated immunity against EBV, and develop immunotherapeutic interventions for the treatment of this and other EBV-opathies. We studied the consequences of PIK3CD GOF mutations on the generation, differentiation, and function of CD8 PIK3CD GOF total and EBV-specific CD8 PIK3CD GOF mutations aberrantly induce exhaustion, senescence, or both and impair cytotoxicity of CD8
Publisher: SAGE Publications
Date: 09-01-2018
Abstract: Existing studies have shown that the use of an inner tube can significantly enhance the effectiveness of confinement in fibre-reinforced polymer-confined hollow columns. The inner tube used in the existing studies, however, generally had a large stiffness and also served as longitudinal reinforcement. The use of a stiff inner tube is inefficient in resisting bending for hollow columns with a relatively small void and may be unnecessary for constraining the inner surface of concrete. Against this background, this article presents the first experimental study on fibre-reinforced polymer-confined hollow columns with an inner polyvinyl chloride tube. The experimental program included a total of 18 specimens which were tested under axial compression. The test variables included the section configuration (i.e. solid specimens, hollow specimens and hollow specimens with a polyvinyl chloride tube) and the thickness of fibre-reinforced polymer. The test results showed that due to the beneficial effect of the polyvinyl chloride tube which provided constraints/confinement from inside, fibre-reinforced polymer-confined hollow columns with an inner polyvinyl chloride tube generally possessed good strength and ductility compared to their counterparts without a polyvinyl chloride tube.
Publisher: Elsevier BV
Date: 12-2019
Publisher: Bentham Science Publishers Ltd.
Date: 12-2008
Publisher: Elsevier BV
Date: 06-2018
Publisher: Elsevier BV
Date: 06-2019
Publisher: American Concrete Institute
Date: 05-2023
DOI: 10.14359/51738503
Publisher: Wiley
Date: 04-2016
DOI: 10.1002/TAL.1282
Publisher: BMJ
Date: 08-2019
DOI: 10.1136/BMJOPEN-2019-031238
Abstract: To date, there is no robust enough test to predict small-for-gestational-age (SGA) infants, who are at increased lifelong risk of morbidity and mortality. To determine the accuracy of metabolomics in predicting SGA babies and elucidate which metabolites are predictive of this condition. Two independent researchers explored 11 electronic databases and grey literature in February 2018 and November 2018, covering publications from 1998 to 2018. Both researchers performed data extraction and quality assessment independently. A third researcher resolved discrepancies. Cohort or nested case–control studies were included which investigated pregnant women and performed metabolomics analysis to evaluate SGA infants. The primary outcome was birth weight th centile—as a surrogate for fetal growth restriction—by population-based or customised charts. Two independent researchers extracted data on study design, obstetric variables and s ling, metabolomics technique, chemical class of metabolites, and prediction accuracy measures. Authors were contacted to provide additional data when necessary. A total of 9181 references were retrieved. Of these, 273 were duplicate, 8760 were removed by title or abstract, and 133 were excluded by full-text content. Thus, 15 studies were included. Only two studies used the fifth centile as a cut-off, and most reports s led second-trimester pregnant women. Liquid chromatography coupled to mass spectrometry was the most common metabolomics approach. Untargeted studies in the second trimester provided the largest number of predictive metabolites, using maternal blood or hair. Fatty acids, phosphosphingolipids and amino acids were the most prevalent predictive chemical subclasses. Significant heterogeneity of participant characteristics and methods employed among studies precluded a meta-analysis. Compounds related to lipid metabolism should be validated up to the second trimester in different settings. CRD42018089985.
Publisher: Civil-Comp Press
Date: 2005
DOI: 10.4203/CCP.81.204
Publisher: Civil-Comp Press
Date: 2013
DOI: 10.4203/CCP.102.154
Publisher: American Society of Civil Engineers (ASCE)
Date: 10-2016
Publisher: Elsevier BV
Date: 10-2018
Publisher: Wiley
Date: 03-2000
DOI: 10.1002/(SICI)1096-9845(200003)29:3<377::AID-EQE911>3.0.CO;2-C
Publisher: American Concrete Institute
Date: 05-2020
DOI: 10.14359/51724591
Publisher: American Society of Civil Engineers (ASCE)
Date: 08-2016
Publisher: Elsevier BV
Date: 06-2018
Publisher: Elsevier BV
Date: 11-2013
DOI: 10.1016/J.SPINEE.2013.06.020
Abstract: Intractable cervical radiculopathy secondary to stenosis or herniated nucleus pulposus is commonly treated with an anterior cervical decompression and fusion (ACDF) procedure. However, there is little evidence in the literature that demonstrates the impact such surgery has on long-term range of motion (ROM) outcomes. The objective of this study was to compare cervical ROM and patient-reported outcomes in patients before and after a 1, 2, or 3 level ACDF. Prospective, nonexperimental. Forty-six patients. The following were measured preoperatively and also at 3 and 6 months after ACDF: active ROM (full and painfree) in three planes (ie, sagittal, coronal, and horizontal), pain visual analog scale, Neck Disability Index, and headache frequency. Patients undergoing an ACDF for cervical radiculopathy had their cervical ROM measured preoperatively and also at 3 and 6 months after the procedure. Neck Disability Index and pain visual analog scale values were also recorded at the same time. Both painfree and full active ROM did not change significantly from the preoperative measurement to the 3-month postoperative measurement (ps>.05) however, painfree and full active ROM did increase significantly in all three planes of motion from the preoperative measurement to the 6-month postoperative measurement regardless of the number of levels fused (ps≤.023). Visual analog scale, Neck Disability Index, and headache frequency all improved significantly over time (ps≤.017). Our results suggest that patients who have had an ACDF for cervical radiculopathy will experience improved ROM 6 months postoperatively. In addition, patients can expect a decrease in pain, an improvement in neck function, and a decrease in headache frequency.
Publisher: Civil-Comp Press
Date: 2003
DOI: 10.4203/CCP.77.26
Publisher: Elsevier BV
Date: 06-2018
Publisher: American Society of Civil Engineers
Date: 29-03-2012
Publisher: Elsevier BV
Date: 06-2017
Publisher: Elsevier BV
Date: 02-2019
Publisher: Elsevier BV
Date: 02-2007
Publisher: Elsevier BV
Date: 04-2022
Publisher: Springer Science and Business Media LLC
Date: 10-2006
Publisher: Elsevier BV
Date: 12-2003
Publisher: Elsevier BV
Date: 07-2014
Publisher: Elsevier BV
Date: 12-2010
Publisher: American Concrete Institute
Date: 07-2022
DOI: 10.14359/51734659
Publisher: CRC Press
Date: 29-10-2009
Publisher: American Society of Civil Engineers (ASCE)
Date: 06-2022
Publisher: Elsevier BV
Date: 06-2017
Publisher: Elsevier BV
Date: 04-2015
Publisher: Springer Science and Business Media LLC
Date: 16-03-2017
Publisher: Elsevier BV
Date: 12-2021
Publisher: Elsevier BV
Date: 2023
Publisher: Informa UK Limited
Date: 07-08-2021
Publisher: American Society of Civil Engineers (ASCE)
Date: 10-2017
Publisher: Springer Science and Business Media LLC
Date: 15-09-2018
DOI: 10.1007/S10875-018-0546-3
Abstract: In iduals with common variable immunodeficiency (CVID) have an increased risk of gastric cancer, and gastrointestinal lymphoma, yet screening for premalignant gastric lesions is rarely offered routinely to these patients. Proposed screening protocols are not widely accepted and are based on gastric cancer risk factors that are not applicable to all CVID patients. Fifty-two CVID patients were recruited for screening gastroscopy irrespective of symptoms or blood results and were compared to 40 controls presenting for gastroscopy for other clinical indications. Overall, 34% of CVID patients had intestinal metaplasia (IM), atrophic gastritis or moderate to severe non-atrophic gastritis, which can increase the risk of gastric cancer, compared to 7.5% of controls (p < 0.01). Focal nodular lymphoid hyperplasia, a precursor lesion for gastrointestinal lymphoma, was seen in eight CVID patients (16%), one of whom was diagnosed with gastrointestinal lymphoma on the same endoscopy. High-risk gastric pathology was associated with increased time since diagnosis of CVID, smoking, Helicobacter pylori, a low-serum pepsinogen I concentration, and diarrhea, but not pepsinogen I/II ratio, iron studies, vitamin B12 levels or upper gastrointestinal symptoms. There was a lower rate of detection of IM when fewer biopsies were taken, and IM and gastric atrophy were rarely predicted by the endoscopist macroscopically, highlighting the need for standardized biopsy protocols. The prevalence of premalignant gastric lesions in patients with CVID highlights the need for routine gastric screening. We propose a novel gastric screening protocol to detect early premalignant lesions and reduce the risk of gastric cancer and gastric lymphoma in these patients.
Publisher: Elsevier BV
Date: 06-2021
Publisher: American Concrete Institute
Date: 2021
DOI: 10.14359/51728094
Publisher: Elsevier BV
Date: 10-2014
Publisher: Emerald
Date: 07-01-2019
Abstract: Many corporate scandals that occurred recently have indicated the importance of a whistle-blowing mechanism in preventing fraud and malpractices from damaging the organizations. By selecting one organization that has experienced a corporate scandal, this study aims to examine factors that influence employee’s intention to blow the whistle to prevent malpractices in the company. In addition, this study also examines the perceptions of employees regarding the business culture in their organization and how this culture impacts their intention to whistle-blow. This study engages in a mixed method of data collection, namely, survey questionnaire and interviews to gather the data. It is found that retaliation is the most important factor that influences the employee’s intention to whistle-blow, followed by the burden to prove the malpractices, cost implications as a result of the wrongdoing and the action taken by the authority as a result of the fraud reporting. In terms of business culture, a large number of employees are reluctant to become a whistle-blower, although a secured and safe whistle-blowing mechanism is in place, indicating that Asian customs of collectivism and assertiveness play a major part in shaping the whistle-blowing mechanism in Malaysian organizations. The results provide further confirmation of the determinants that influence employees to report wrongdoings in the organizations. This study however may subject to self-reported data biasness because of sensitivity of the research that related to fraud and immoral behaviours that occur in the company. Owing to this sensitivity, the study only focuses on employees’ internal whistle-blowing intentions rather than their actual intentions. This study helps the management to understand the working culture in the company so that they can identify the weak area of governance which needs improvement such as whistle-blower protection. This study is original, as it focuses on the employees in a big organization such as government link companies that have experienced corporate scandals albeit having whistle-blowing mechanism in place. In addition, the finding of this study contributes to the theory and body of the literature on the whistle-blowing determinants, currently scarce in the context of a developing country like Malaysia.
Publisher: American Concrete Institute
Date: 07-2017
DOI: 10.14359/51689781
Publisher: American Society of Civil Engineers (ASCE)
Date: 04-2019
Publisher: American Society of Civil Engineers (ASCE)
Date: 02-2021
Publisher: Elsevier BV
Date: 2018
Publisher: Elsevier BV
Date: 2017
Publisher: American Society of Civil Engineers (ASCE)
Date: 08-2009
Publisher: Elsevier BV
Date: 03-2017
Publisher: Civil-Comp Press
Date: 2011
DOI: 10.4203/CCP.96.217
Publisher: Elsevier BV
Date: 09-2022
Publisher: Springer Science and Business Media LLC
Date: 27-01-2011
Publisher: Elsevier BV
Date: 08-2017
Publisher: ASTM International
Date: 02-07-2019
DOI: 10.1520/JTE20180660
Publisher: American Concrete Institute
Date: 07-2020
DOI: 10.14359/51723509
Publisher: Elsevier BV
Date: 04-2008
DOI: 10.1080/00313020801911470
Abstract: Patients with common variable immunodeficiency (CVID) often have defects in post-antigenic B-cell differentiation with fewer memory B cells and impaired isotype switching. We aimed to classify CVID patients according to these defects and determine whether this predicted clinical manifestations. We analysed the memory marker CD27, maturation marker CD21, and IgD on peripheral blood B cells from 31 CVID patients and 23 controls using a whole-blood lysis technique, allocated patients according to two classifications ('Freiburg' and 'Paris') and correlated results with clinical manifestations. CVID patients had fewer memory (CD27(+)) B cells and isotype-switched (IgD(-)) memory B cells in absolute number and proportion. Many CVID patients had increased immature (CD21(-)) B cells. Lymphoproliferation and autoimmune cytopenias were found almost exclusively in these patients, including Freiburg group Ia (decreased switched memory and increased immature B cells), but also those with normal switched memory and increased immature B cells. The Paris classification was less useful in predicting clinical manifestations. CVID is associated with defects in memory B-cell differentiation. Subclassification helps identify patients with clinical manifestations, particularly lymphoproliferation and autoimmune cytopenias in those with impaired B-cell maturation and isotype switching. Routine B-cell phenotyping may assist clinicians in predicting these clinical features.
Publisher: American Concrete Institute
Date: 05-2019
DOI: 10.14359/51714473
Publisher: American Society of Civil Engineers (ASCE)
Date: 03-2014
Publisher: Elsevier BV
Date: 03-2017
Publisher: American Concrete Institute
Date: 05-2023
DOI: 10.14359/51738683
Publisher: CSIRO Publishing
Date: 2011
DOI: 10.1071/HE11004
Publisher: American Concrete Institute
Date: 09-2018
DOI: 10.14359/51702250
Publisher: Elsevier BV
Date: 07-2020
Publisher: Elsevier BV
Date: 11-2003
Publisher: Elsevier BV
Date: 08-2018
Publisher: American Concrete Institute
Date: 09-2018
DOI: 10.14359/51702375
Publisher: Elsevier BV
Date: 08-2018
Publisher: Civil-Comp Press
Date: 2003
DOI: 10.4203/CCP.77.115
Publisher: American Society of Civil Engineers (ASCE)
Date: 09-2020
Publisher: American Concrete Institute
Date: 07-2019
DOI: 10.14359/51715573
Publisher: Office of the Academic Executive Director, University of Tasmania
Date: 2004
DOI: 10.53761/1.1.1.3
Abstract: This article describes the design of a web-based environment that links teaching strategies used in different faculties with graduate attributes. Whilst graduate attributes have existed at the University of Wollongong since the 1990s, this is the first time teaching strategies that enable students to develop these attributes have been articulated and shared electronically. The strategies are the practical or tacit knowledge of university teaching. The paper provides a background for the role of graduate attributes in higher education and explains the reason for focussing on teaching strategies. It describes the website resource with some ex les and outlines dissemination and evaluation plans for the initiative. It is hoped that the website will become a “growing” site as a resource for a university community to share teaching strategies across different faculties.
Publisher: Elsevier BV
Date: 05-2019
Publisher: Elsevier BV
Date: 10-2018
Publisher: Elsevier BV
Date: 02-2020
Publisher: Informa UK Limited
Date: 2010
Publisher: American Society of Civil Engineers (ASCE)
Date: 06-2011
Publisher: American Concrete Institute
Date: 05-2017
DOI: 10.14359/51689439
Publisher: Elsevier BV
Date: 02-2019
Publisher: Elsevier BV
Date: 06-2014
Publisher: American Society of Civil Engineers (ASCE)
Date: 06-2022
Publisher: Elsevier BV
Date: 04-2006
Publisher: Thomas Telford Ltd.
Date: 08-2017
Abstract: A capacity model for shear strength of reinforced-concrete exterior beam–column joints subjected to quasi-static cyclic loading is established. In this model, only a fraction of this force is asserted to be transferred into the joint core, the remainder is assumed to be transferred into the adjacent column. A biaxial failure criterion of concrete is adopted to predict shear failure of the joint core caused by a combination of principal compression and tension stresses. The contribution of the shear reinforcement is accounted for by improving the tensile strength of the concrete. In addition, the special features of the proposed model include: first, the asynchronicity of concrete and shear reinforcement in tensile strength is taken into account and, second, the role of column axial stress is accounted for by its influence on both the magnitude and direction of principal tensile and compressive stresses at the joint core. The validity of the proposed model is evaluated by comparing the predicted shear strengths with 142 test results collected from the literature and with five other analytical models. This evaluation showed that the proposed model can predict shear strength with better reliability.
Publisher: Elsevier BV
Date: 03-2003
Publisher: ASTM International
Date: 03-2019
DOI: 10.1520/ACEM20190014
Publisher: Elsevier BV
Date: 10-2021
Publisher: American Society of Civil Engineers (ASCE)
Date: 12-2014
Publisher: ASTM International
Date: 25-04-2018
DOI: 10.1520/JTE20170067
Publisher: Civil-Comp Press
Date: 2002
DOI: 10.4203/CCP.75.42
Publisher: American Society of Civil Engineers (ASCE)
Date: 10-2012
Publisher: Elsevier BV
Date: 12-2022
Publisher: BMJ
Date: 02-02-2017
Publisher: Elsevier BV
Date: 07-2001
Publisher: Elsevier BV
Date: 05-2019
Publisher: Civil-Comp Press
Date: 1999
DOI: 10.4203/CCP.60.6.9
Publisher: WIT Press
Date: 21-04-2009
DOI: 10.2495/ERES090131
Publisher: American Concrete Institute
Date: 03-2022
DOI: 10.14359/51734342
Publisher: Elsevier BV
Date: 10-2019
Publisher: Elsevier BV
Date: 12-2021
Publisher: Elsevier BV
Date: 03-2021
Publisher: Elsevier BV
Date: 2023
Publisher: American Astronomical Society
Date: 16-02-2021
Abstract: We present a catalog of 4195 optically confirmed Sunyaev–Zel’dovich (SZ) selected galaxy clusters detected with signal-to-noise ratio in 13,211 deg 2 of sky surveyed by the Atacama Cosmology Telescope (ACT). Cluster candidates were selected by applying a multifrequency matched filter to 98 and 150 GHz maps constructed from ACT observations obtained from 2008 to 2018 and confirmed using deep, wide-area optical surveys. The clusters span the redshift range 0.04 z 1.91 (median z = 0.52). The catalog contains 222 z 1 clusters, and a total of 868 systems are new discoveries. Assuming an SZ signal versus mass-scaling relation calibrated from X-ray observations, the s le has a 90% completeness mass limit of M 500c 3.8 × 10 14 M ⊙ , evaluated at z = 0.5, for clusters detected at signal-to-noise ratio in maps filtered at an angular scale of 2.′4. The survey has a large overlap with deep optical weak-lensing surveys that are being used to calibrate the SZ signal mass-scaling relation, such as the Dark Energy Survey (4566 deg 2 ), the Hyper Suprime-Cam Subaru Strategic Program (469 deg 2 ), and the Kilo Degree Survey (825 deg 2 ). We highlight some noteworthy objects in the s le, including potentially projected systems, clusters with strong lensing features, clusters with active central galaxies or star formation, and systems of multiple clusters that may be physically associated. The cluster catalog will be a useful resource for future cosmological analyses and studying the evolution of the intracluster medium and galaxies in massive clusters over the past 10 Gyr.
Publisher: WIT Press
Date: 07-09-2011
DOI: 10.2495/ERES110191
Publisher: Informa UK Limited
Date: 07-06-2019
Publisher: Elsevier BV
Date: 12-2017
Publisher: Elsevier BV
Date: 2022
DOI: 10.2139/SSRN.4092267
Publisher: Elsevier BV
Date: 07-2001
Publisher: Elsevier BV
Date: 05-2019
Publisher: Thomas Telford Ltd.
Date: 08-2022
Abstract: An experimental investigation was carried out on a novel type of concrete-filled tube column, which used geopolymer concrete and basalt-fibre-reinforced-polymer reinforcing bars and confinement tube. Geopolymer concrete was used in place of ordinary Portland cement concrete to counter the sustainability challenges of conventional cement manufacture. Longitudinal basalt-fibre-reinforced-polymer bars were used to replace steel reinforcement to avoid corrosion, while basalt-fibre-reinforced-polymer tube confinement was used to replace the conventionally used steel helix to enhance strength and ductility. Compressive load–deformation behaviour of 200 mm dia., 800 mm high specimens under concentric, 25 mm eccentric, 50 mm eccentric and four-point bending loads was experimentally investigated. Experimental axial load–bending moment diagrams were then produced. Although geopolymer concrete is normally considered to be more brittle than Portland cement concrete, the test results showed that the specimens with geopolymer concrete were more ductile compared to those with Portland cement concrete. It was also found that increased load eccentricity resulted in ductility enhancement in specimens with both types of concrete with basalt-fibre-reinforced-polymer bars and tubes, while steel-reinforced specimens suffered loss of ductility with increased load eccentricity.
Publisher: Wiley
Date: 06-10-2010
DOI: 10.1111/J.1360-0443.2010.03137.X
Abstract: To illustrate ways in which industry control over the gambling market and its regulatory system have enabled rapid proliferation in gambling consumption and harm. To discuss the relationship between government regulation and the accessibility, marketing and technologies of electronic gambling machines in Australia and New Zealand. The regulatory framework for gambling in both countries has encouraged highly accessible,regressively distributed and heavily marketed high-impact electronic gambling machines. This framework has developed in large part through the conjunction of government revenue needs and the adaptation of a folk model of gambling appropriated by gambling businesses and engineered to incorporate a discourse that legitimate their gambling businesses. Governments should be encouraged to invest in 'upstream' public health strategies that contain the economic and social drivers for intensifying gambling consumption. One key aspect involves questioning the most suitable scale, location and marketing of gambling operations, and the reliance of government on gambling revenues (whether directly or as substitution for other government expenditure). Technological solutions to disrupt the development of obsessive gambling habits are also available and are likely to reduce gambling-related harm.
Publisher: Elsevier BV
Date: 08-2018
Publisher: Elsevier BV
Date: 10-2021
Publisher: Elsevier BV
Date: 12-2018
Publisher: AMPCo
Date: 07-2010
DOI: 10.5694/J.1326-5377.2010.TB03804.X
Abstract: To determine changes in the pattern of use of standard general practice consultations, and the degree to which any changes are offset by the use of special Medicare Benefits Schedule (MBS) items. Population-based retrospective analysis of age- and sex-standardised Medicare claims data (1994-2009) on the utilisation of general practice standard consultations (Levels A, B, C and D) alone and in combination with health assessments and care plans and other special MBS items. Utilisation rates of Level C and D (long) consultations increased consistently from 1994 to 2004, but by 2009 a considerable decline had occurred. A reverse of this pattern was observed for Level A (short) consultations. When utilisation rates for special items and long consultations were combined, the combined utilisation rate followed an upward trend until 2007, but also declined in 2008 and 2009. The decline in the use of Level C and D consultations in recent years has been dramatic and accompanied by an increase in use of Level A consultations. While the use of special items has offset the decline in long consultations, this compensating effect has weakened in the past 2 years. This pattern is at odds with health policy objectives that rely on long consultations to provide preventive care and chronic disease management. Given the current situation, the recently introduced Medicare reforms (May 2010), including changes to Levels B, C and D consultation item descriptors, may not be sufficient to change consultation patterns.
Publisher: CRC Press
Date: 21-06-2012
DOI: 10.1201/B12352-168
Publisher: American Society of Civil Engineers (ASCE)
Date: 02-2017
Publisher: Elsevier BV
Date: 2007
Publisher: Elsevier BV
Date: 05-2015
Publisher: Elsevier BV
Date: 11-2018
Publisher: Wiley
Date: 12-05-2020
Publisher: Elsevier BV
Date: 06-2020
Publisher: American Society of Civil Engineers (ASCE)
Date: 2015
Publisher: American Concrete Institute
Date: 03-2023
DOI: 10.14359/51738489
Publisher: CRC Press
Date: 21-06-2012
DOI: 10.1201/B12352-171
Publisher: American Society of Civil Engineers (ASCE)
Date: 10-2018
Publisher: Elsevier BV
Date: 09-2017
Publisher: Civil-Comp Press
Date: 2007
DOI: 10.4203/CCP.86.168
Publisher: CRC Press
Date: 06-02-2017
Publisher: Elsevier BV
Date: 04-2023
Publisher: Elsevier BV
Date: 07-2015
Publisher: SAGE Publications
Date: 21-07-2017
Abstract: Applications of high-strength steel products in civil engineering have been limited by elastic local buckling, by the perceived lack of ductility, and by the perceived difficulties of welding such steels. This article proposes a new column (i.e. high-strength steel plate–concrete-filled fiber-reinforced polymer tube) consisting of an outer fiber-reinforced polymer tube, concrete infill, and encased high-strength steel plates that are connected to each other by bolted angle brackets at discrete elevations. The column offers an ideal opportunity for the use of high-strength steel plates in construction, with their high yield stresses being fully utilized and without welding (and without welding residual stresses). The rationale for the column form and its expected advantages are explained and demonstrated through laboratory tests. Prefabricated glass fiber-reinforced polymer tubes of 1.5 and 3.0 mm thick and 203 mm diameter were infilled with concrete having a nominal strength of 32 MPa, with most specimens encasing steel plates of various configurations and yield stresses ranging from 290 to 455 MPa. Results from concentric and eccentric compression tests involving 13 specimens are presented to confirm the expected structural advantages. The results demonstrated that the concrete in the tested specimens was very effectively confined, and that buckling of all the steel plates was prevented by the encasing concrete up to and beyond the rupture of the fiber-reinforced polymer tubes, leading to full structural utilization of the construction materials and very ductile column responses under concentric and eccentric loadings. The needs for future research on high-strength steel plate–concrete-filled fiber-reinforced polymer tube columns are also discussed.
Publisher: Civil-Comp Press
Date: 2007
DOI: 10.4203/CCP.86.174
Publisher: American Society of Civil Engineers (ASCE)
Date: 07-2018
Publisher: American Society of Civil Engineers (ASCE)
Date: 04-2023
Publisher: Elsevier BV
Date: 2011
Publisher: Elsevier BV
Date: 2013
Publisher: Informa UK Limited
Date: 24-10-2013
Publisher: Elsevier BV
Date: 02-2020
Publisher: Informa UK Limited
Date: 28-03-2019
Publisher: Elsevier BV
Date: 06-2014
Publisher: Elsevier BV
Date: 12-2017
Publisher: Elsevier BV
Date: 06-2018
Publisher: IOP Publishing
Date: 08-2023
DOI: 10.1088/1757-899X/1289/1/012027
Abstract: This study aims to evaluate the effect of the cross-section modification on the performance of square reinforced concrete (SRC) columns discontinuously strengthened with CFRP bands. In line with this research aim, the performance of SRC columns under eccentric and concentric compression was compared with that of circularized square RC (CSRC) columns. Six RC columns with 800 mm height including three SRC columns with 150 mm side length and three CSRC columns with 212 mm diameter were prepared and tested. The test results revealed that SRC columns achieved a substantial enhancement of strength and deformation by applying cross-section modification before strengthening with discontinuous CFRP bands. It was also found that SRC columns received a substantial improvement of deformation and considerable improvement of strength by strengthening with discontinuous CFRP bands.
Publisher: Elsevier BV
Date: 2014
Publisher: American Society of Civil Engineers (ASCE)
Date: 07-2018
Publisher: Elsevier BV
Date: 08-2017
Publisher: Thomas Telford Ltd.
Date: 05-2014
Abstract: A new empirical model to estimate the joint shear strength of both exterior and interior beam–column connections is proposed. In the model, four parameters that have the most influence on joint shear strength are considered. Among these four, a new parameter is introduced to consider the bond condition and the possibility of beam bars transferring joint shear force into the columns. Consideration of this parameter in the model significantly improves the accuracy of the predicted joint shear strength. To calibrate the model, a large database of 98 reinforced concrete (RC) exterior and 73 RC interior beam–column connections displaying joint failure mode was compiled from the literature. A parametric study was also carried out to evaluate the dependence of the predicted to tested joint shear strength ratio on the four influence parameters using the database. The proposed model showed superior performance over existing models. Moreover, comparisons of the predicted joint shear strength with experimental results and with four existing models showed the accuracy of the proposed model.
Publisher: American Society of Civil Engineers (ASCE)
Date: 11-1998
Publisher: Springer International Publishing
Date: 27-09-2022
Publisher: Elsevier BV
Date: 03-2022
Publisher: Trans Tech Publications, Ltd.
Date: 11-2010
DOI: 10.4028/WWW.SCIENTIFIC.NET/AMM.37-38.862
Abstract: As an important member of smart materials, magnetorheological elastomers (MREs) exhibit characteristics that their modulus can be controlled by an external magnetic field. Based on these experimental results, a viscoelastic solid model with four parameters was proposed to predict the performance of MRE. A building model, three stories high, was constructed using MATLAB SIMULINK to evaluate the performance of an MRE device in structural control. In addition, the performance of an MRF d er and an MRE device in structural control, where the resultant peak force was selected as a criterion in the evaluation process, was compared and discussed. Two controllers, passive on and passive off control strategy were used to compare the response of structure. The effectiveness of an MRE bearing in structural control was well justified.
Publisher: Elsevier BV
Date: 09-2016
Publisher: Springer International Publishing
Date: 27-09-2022
Publisher: American Society of Civil Engineers
Date: 04-08-2000
DOI: 10.1061/40513(279)36
Publisher: Elsevier BV
Date: 02-2023
Publisher: American Society of Civil Engineers (ASCE)
Date: 10-2022
Publisher: Civil-Comp Press
Date: 2007
DOI: 10.4203/CCP.86.180
Publisher: Informa UK Limited
Date: 05-02-2018
Publisher: Elsevier BV
Date: 12-2021
Publisher: American Society of Civil Engineers (ASCE)
Date: 12-2013
Publisher: Elsevier BV
Date: 04-1996
Publisher: Elsevier BV
Date: 11-2018
Location: United Kingdom of Great Britain and Northern Ireland
Start Date: 2021
End Date: 2024
Funder: Australian Research Council
View Funded ActivityStart Date: 06-2016
End Date: 06-2018
Amount: $800,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 12-2021
End Date: 12-2024
Amount: $325,000.00
Funder: Australian Research Council
View Funded Activity