ORCID Profile
0000-0002-8986-2795
Current Organisation
University of Queensland
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In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Nanobiotechnology | Nanomedicine | Physical Chemistry of Materials | Nanotechnology | Macromolecular and Materials Chemistry | Macromolecular and Materials Chemistry not elsewhere classified |
Expanding Knowledge in the Chemical Sciences | Human Pharmaceutical Products not elsewhere classified | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in Technology
Publisher: MDPI AG
Date: 17-12-2018
Abstract: The EphA3 receptor has recently emerged as a functional tumour-specific therapeutic target in glioblastoma (GBM). EphA3 is significantly elevated in recurrent disease, is most highly expressed on glioma stem cells (GSCs), and has a functional role in maintaining self-renewal and tumourigenesis. An unlabelled EphA3-targeting therapeutic antibody is currently under clinical assessment in recurrent GBM patients. In this study, we assessed the efficacy of EphA3 antibody drug conjugate (ADC) and radioimmunotherapy (RIT) approaches using orthotopic animal xenograft models. Brain uptake studies, using positron emission tomography/computed tomography (PET/CT) imaging, show EphA3 antibodies are effectively delivered across the blood-tumour barrier and accumulate at the tumour site with no observed normal brain reactivity. A robust anti-tumour response, with no toxicity, was observed using EphA3, ADC, and RIT approaches, leading to a significant increase in overall survival. Our current research provides evidence that GBM patients may benefit from pay-loaded EphA3 antibody therapies.
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9BM00957D
Abstract: Properties of hyperbranched polymer surface chemistry control cellular distribution.
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2CC02443H
Abstract: Pre-targeting of bispecific antibodies is probed to enhance tumour retention while limiting clearance of administered multifunctional branched PEGylated nanomedicines. The temporal influence of pre-targeting on polymer interaction with tumour cells and tissue is explored using
Publisher: American Chemical Society (ACS)
Date: 18-03-2010
DOI: 10.1021/MA902597P
Publisher: American Chemical Society (ACS)
Date: 29-10-2008
DOI: 10.1021/MA8018365
Publisher: Wiley
Date: 23-10-2023
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1CC00821H
Abstract: Thermolysis of a diazirine end group of a Br-functional PCL leads to carbene generation and subsequent hyperbranched polymers. Grafting of a hydrophilic PEG yields hiphilic polymers which self-assemble into spherical core–shell nanoparticles.
Publisher: Elsevier BV
Date: 07-2021
Publisher: Elsevier BV
Date: 04-2022
DOI: 10.1016/J.BIOMATERIALS.2022.121416
Abstract: Personalised nanomedicine is an advancing field which has developed significant improvements for targeting therapeutics to aggressive cancer and with fewer side effects. The treatment of gliomas such as glioblastoma (or other brain tumours), with nanomedicine is complicated by a commonly poor accumulation of drugs in tumour tissue owing to the partially intact blood-brain barrier (BBB). Nonetheless, the BBB becomes compromised following surgical intervention, and gradually with disease progression. Increased vasculature permeability generated by a tumour, combined with decreased BBB integrity, offers a mechanism to enhance therapeutic outcomes. We monitored a spontaneous glioma tumour model in immunocompetent mice with ongoing T2-weighted and contrast-enhanced T1-weighted magnetic resonance imaging gradient echo and spin echo sequences to predict an optimal "leakiness" stage for nanomedicine injections. To ascertain the effectiveness of targeted nanomedicines in treating brain tumours, subsequent systemic administration of targeted hyperbranched polymers was then utislised, to deliver the therapeutic payload when both the tumour and brain vascularity had become sufficiently susceptible to allow drug accumulation. Treatment with either doxorubicin-loaded hyperbranched polymer, or the same nanomedicine targeted to an ephrin receptor (EphA2) using a bispecific antibody, resulted in uptake of chemotherapeutic doxorubicin in the tumour and in reduced tumour growth. Compared to vehicle and doxorubicin only, nanoparticle delivered doxorubicin resulted in increased tumour apoptosis, while averting cardiotoxicity. This suggests that polyethylene based (PEGylated)-nanoparticle delivered doxorubicin could provide a more efficient treatment in tumours with a disrupted BBB, and that treatment should commence immediately following detection of gadolinium permeability, with early detection and ongoing 'leakiness' monitoring in susceptible patients being a key factor.
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6PY01674J
Abstract: The controlled ring-opening polymerisation (ROP) of α-bromo-ε-caprolactone (αBrCL), a derivative of ε-caprolactone (εCL), and its copolymerisation with εCL is reported.
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C0CC05478J
Abstract: Control of the rates of orthogonal 'click' reactions in one pot allowed the design of highly branched macromolecular architectures. Construction of these architectures via a ergent, convergent or parallel sequence was modulated by the copper catalyst activity. This approach reduced the number of purification and chemical protection steps.
Publisher: Wiley
Date: 03-2010
Abstract: The potentially hexadentate mixed-donor cage ligand 1-methyl-8-amino-3,13,16-trithia-6,10,19-triazabicyclo[6.6.6]eicosane (AMME-N(3)S(3)sar sar=sarcophagine) displays variable coordination modes in a complex with copper(II). In the absence of coordinating anions, the ligand adopts a conventional hexadentate N(3)S(3) binding mode in the complex [Cu(AMME-N(3)S(3)sar)](ClO(4))(2) that is typical of cage ligands. This structure was determined by X-ray crystallography and solution spectroscopy (EPR and NIR UV/Vis). However, in the presence of bromide ions in DMSO, clean conversion to a five-coordinate bromido complex [Cu(AMME-N(3)S(3)sar)Br](+) is observed that features a novel tetradentate (N(2)S(2))-coordinated form of the cage ligand. This copper(II) complex has also been characterized by X-ray crystallography and solution spectroscopy. The mechanism of the reversible interconversion between the six- and five-coordinated copper(II) complexes has been studied and the reaction has been resolved into two steps the rate of the first is linearly dependent on bromide ion concentration and the second is bromide independent. Electrochemistry of both [Cu(AMME-N(3)S(3)sar)](2+) and [Cu(AMME-N(3)S(3)sar)Br](+) in DMSO shows that upon reduction to the monovalent state, they share a common five-coordinated form in which the ligand is bound to copper in a tetradentate form exclusively, regardless of whether a six- or five-coordinated copper(II) complex is the precursor.
Publisher: Wiley
Date: 08-04-2010
DOI: 10.1002/POLA.23991
Publisher: American Chemical Society (ACS)
Date: 10-11-2009
DOI: 10.1021/MA9014565
Publisher: Wiley
Date: 21-06-2007
DOI: 10.1002/POLA.22101
Publisher: American Chemical Society (ACS)
Date: 18-07-2011
DOI: 10.1021/JA205193F
Abstract: Copper(I) polyamine complexes have emerged as excellent atom-transfer radical polymerization catalysts. The rate of their reaction with organic halide initiators (the so-called activation step) varies across a broad range, depending on both the structure of the copper complex and the initiator. Herein, we report a new technique for determining the rate of copper-catalyzed activation (k(act)) using cyclic voltammetry coupled with electrochemical simulation. This method is applied to measuring k(act) for one of the most active catalysts, [Cu(I)(Me(6)tren)](+) (Me(6)tren = N,N,N-tris-(2-(dimethylamino)ethyl)amine), in reaction with ethyl bromoisobutyrate.
Publisher: Royal Society of Chemistry (RSC)
Date: 2010
DOI: 10.1039/B9PY00315K
Publisher: American Chemical Society (ACS)
Date: 25-05-2011
DOI: 10.1021/MA200649B
Publisher: American Chemical Society (ACS)
Date: 16-09-2020
Publisher: American Chemical Society (ACS)
Date: 02-03-2011
DOI: 10.1021/MA200148B
Publisher: Elsevier BV
Date: 05-2021
Publisher: American Chemical Society (ACS)
Date: 28-10-2020
Publisher: Wiley
Date: 09-08-2011
DOI: 10.1002/POLA.24896
Publisher: American Chemical Society (ACS)
Date: 09-06-2015
Publisher: Springer Science and Business Media LLC
Date: 02-01-2021
DOI: 10.1007/S10620-020-06752-Y
Abstract: Colorectal cancer is a leading cause of cancer-related death worldwide and approximately 20% of cases can be attributed to a mutation in the BRAF oncogene. Curcumin is a promising chemopreventive agent with various anti-cancer benefits. Although curcumin has been reported to have poor bioavailability, this limitation has been overcome by the formulation of nano-carriers. In this preclinical study, we investigated the ability of an improved formulation of curcumin to reduce the incidence of Braf mutant carcinoma. To investigate curcumin as a chemopreventive for Braf mutant colorectal cancer in a preclinical study utilizing a murine model of serrated neoplasia. An intestine-specific Braf mutant murine model (Braf At completion of the study (14 months), it was found that curcumin did not reduce the incidence or multiplicity of murine serrated lesions but did significantly reduce the number of invasive carcinomas (RR 0.83, 95% CI 0.69-0.9985, P = 0.0360) compared to control. We have performed the first long-term study assessing curcumin's effect on the development of serrated neoplasia. We found that curcumin significantly reduces the risk of developing Braf mutant colorectal cancer. Our data supports further investigation of curcumin as a chemopreventive to reduce the risk of colorectal cancer arising via the serrated pathway.
Publisher: American Chemical Society (ACS)
Date: 12-12-2007
DOI: 10.1021/MA701993W
Publisher: American Chemical Society (ACS)
Date: 25-02-2021
Abstract: Improving our understanding of how design choices in materials synthesis impact biological outcomes is of critical importance in the development of nanomedicines. Here, we show that fluorophore labeling of polymer nanomedicine candidates significantly alters their transport and cell association in multi-cellular tumor spheroids and their penetration in breast cancer xenografts, dependent on the type of the fluorophore and their positioning within the macromolecular structure. These data show the critical importance of the biomaterials structure and architecture in their tissue distribution and intracellular trafficking, which in turn govern their potential therapeutic efficacy. The broader implication of these findings suggests that when developing materials for medical applications, great care should be taken early on in the design process as relatively simple choices may have downstream impacts that could potentially skew preclinical biology data.
Publisher: American Chemical Society (ACS)
Date: 13-05-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2014
DOI: 10.1021/MA500428E
Publisher: Elsevier BV
Date: 2021
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0SC00078G
Abstract: There remain several key challenges to existing therapeutic systems for cancer therapy, such as quantitatively determining the true, tissue-specific drug release profile in vivo , as well as reducing side-effects for an increased standard of care.
Publisher: CSIRO Publishing
Date: 2010
DOI: 10.1071/CH10092
Abstract: The single electron transfer-nitroxide radical coupling (SET-NRC) reaction has been used to produce multiblock polymers with high molecular weights in under 3 min at 50°C by coupling a difunctional telechelic polystyrene (Br-PSTY-Br) with a dinitroxide. The well known combination of dimethyl sulfoxide as solvent and Me6TREN as ligand facilitated the in situ disproportionation of CuIBr to the highly active nascent Cu0 species. This SET reaction allowed polymeric radicals to be rapidly formed from their corresponding halide end-groups. Trapping of these carbon-centred radicals at close to diffusion controlled rates by dinitroxides resulted in high-molecular-weight multiblock polymers. Our results showed that the disproportionation of CuI was critical in obtaining these ultrafast reactions, and confirmed that activation was primarily through Cu0. We took advantage of the reversibility of the NRC reaction at elevated temperatures to decouple the multiblock back to the original PSTY building block through capping the chain-ends with mono-functional nitroxides. These alkoxyamine end-groups were further exchanged with an alkyne mono-functional nitroxide (TEMPO–≡) and ‘clicked’ by a CuI-catalyzed azide/alkyne cycloaddition (CuAAC) reaction with N3–PSTY–N3 to reform the multiblocks. This final ‘click’ reaction, even after the consecutive decoupling and nitroxide-exchange reactions, still produced high-molecular-weight multiblocks efficiently. These SET-NRC reactions would have ideal applications in re-usable plastics and possibly as self-healing materials.
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2PY00257D
Abstract: Modern polymerisation techniques allow synthesis of functional block copolymers that can self-assemble into degradable nanoparticles (NPs) of different sizes and conformations.
Publisher: American Chemical Society (ACS)
Date: 10-08-2007
DOI: 10.1021/MA071121N
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D2TA08019B
Abstract: Development of biodegradable and functionalised face mask nonwovens to address the plastic pollution issue generated by disposable face masks.
Publisher: Wiley
Date: 16-11-2007
DOI: 10.1002/POLA.22366
Publisher: American Chemical Society (ACS)
Date: 05-12-2022
Publisher: Wiley
Date: 03-03-2006
Publisher: American Chemical Society (ACS)
Date: 31-01-2008
DOI: 10.1021/MA702707E
Publisher: Wiley
Date: 16-05-2018
DOI: 10.1002/0471440264.PST159.PUB2
Abstract: Hyperbranched polymers (HBPs) have shown widespread academic and commercial success in the preparation of films and novel materials, and now are emerging into the biomedical research space as nanocarriers for use in drug delivery and diagnostics. HBPs exhibit ideal sizes for delivery in vivo , have well‐established chemistries for their synthesis, as well as offering multiple methods of incorporation of a variety of targeting, therapeutic, and diagnostic moieties. By choice of material and functionality, their biostability or biodegradability can be fine‐tuned for multistaged or time‐delayed release of therapeutics. With significant advances in the development of nanomedicines, in particular chemistries surrounding biomolecule conjugation and the evolution of imaging techniques, the multimodal capabilities of HBPs combined with facile and controlled synthetic engineering of HBPs have resulted in properties that are ideal for their application as nanocarriers. While HBP nanocarriers offer limitless synthetic opportunity, to address the many biological challenges that are now well‐established in nanotherapeutics, new approaches to how HBPs are designed are required. This overview aims to address the points that must be considered in the biologically driven nanomaterial design of HBP nanocarriers.
Publisher: Wiley
Date: 11-12-2020
Publisher: MDPI AG
Date: 02-07-2021
DOI: 10.3390/NANO11071745
Abstract: The ability to predict the behaviour of polymeric nanomedicines can often be obfuscated by subtle modifications to the corona structure, such as incorporation of fluorophores or other entities. However, these interactions provide an intriguing insight into how selection of molecular components in multifunctional nanomedicines contributes to the overall biological fate of such materials. Here, we detail the internalisation behaviours of polymeric nanomedicines across a suite of cell types and extrapolate data for distinguishing the underlying mechanics of cyanine-5-driven interactions as they pertain to uptake and endosomal escape. By correlating the variance of rate kinetics with endosomal escape efficiency and endogenous lipid polarity, we identify that observed cell-type dependencies correspond with an underlying susceptibility to dye-mediated effects and nanomedicine accumulation within polar vesicles. Further, our results infer that the ability to translocate endosomal membranes may be improved in certain cell types, suggesting a potential role for diagnostic moieties in trafficking of drug-loaded nanocarriers.
Publisher: MDPI AG
Date: 10-01-2017
DOI: 10.3390/JSAN6010001
Publisher: Wiley
Date: 22-01-2008
DOI: 10.1002/POLA.22528
Publisher: Elsevier BV
Date: 11-2023
Publisher: Wiley
Date: 06-10-2016
Publisher: Elsevier BV
Date: 12-2019
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2CY00744D
Abstract: Self-assembling transesterification catalyst inspired by the catalytic triad.
Publisher: Springer Science and Business Media LLC
Date: 19-01-2021
DOI: 10.1038/S41467-020-20610-5
Abstract: Complex biological tissues are highly viscoelastic and dynamic. Efforts to repair or replace cartilage, tendon, muscle, and vasculature using materials that facilitate repair and regeneration have been ongoing for decades. However, materials that possess the mechanical, chemical, and resorption characteristics necessary to recapitulate these tissues have been difficult to mimic using synthetic resorbable biomaterials. Herein, we report a series of resorbable elastomer-like materials that are compositionally identical and possess varying ratios of cis : trans double bonds in the backbone. These features afford concomitant control over the mechanical and surface eroding degradation properties of these materials. We show the materials can be functionalized post-polymerization with bioactive species and enhance cell adhesion. Furthermore, an in vivo rat model demonstrates that degradation and resorption are dependent on succinate stoichiometry in the elastomers and the results show limited inflammation highlighting their potential for use in soft tissue regeneration and drug delivery.
Publisher: American Chemical Society (ACS)
Date: 20-07-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5PY01156F
Abstract: The copolymerization of vinyl acetate (VAc) and 2-methylene-1,3-dioxepane (MDO), as well as the homopolymerization of MDO in the presence of a p -methoxyphenyl xanthate chain transfer agent (CTA) is reported and comparison of the homopolymerization of MDO with other known xanthates was also investigated.
Location: United Kingdom of Great Britain and Northern Ireland
Start Date: 2013
End Date: 2014
Funder: Royal Society
View Funded ActivityStart Date: 2020
End Date: 2023
Funder: Advance Queensland
View Funded ActivityStart Date: 2022
End Date: 2024
Funder: Australian Research Council
View Funded ActivityStart Date: 2019
End Date: 2021
Funder: Australian Research Council
View Funded ActivityStart Date: 09-2022
End Date: 08-2025
Amount: $510,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 11-2019
End Date: 12-2022
Amount: $390,000.00
Funder: Australian Research Council
View Funded Activity