ORCID Profile
0000-0002-1715-5012
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Publisher: American Chemical Society (ACS)
Date: 09-10-2020
DOI: 10.1021/ACSMACROLETT.0C00557
Abstract: Poly(ethylene glycol) (PEG) is the most used hydrophilic polymer for low-fouling coatings to minimize nonspecific interactions. The PEG molecular weight or its length as well as surface density are typically considered as the main impacts on the control over low-fouling properties. However, the influence of PEG monodispersity on such investigations is typically ignored and rarely reported. Herein, we report the assembly of PEGylated coatings on planar surfaces and Au nanorods (AuNRs) using a series of monodisperse PEG (Mono-PEG) with exact molecular weights and commonly used polydisperse PEG (Poly-PEG) to investigate the effect of the PEG molecular weight and monodispersity on the low-fouling properties. Nonspecific interactions with proteins or cells on PEGylated planar surfaces can be significantly reduced when Mono-PEG with a molecular weight of 752 Da and above is used, while a higher average molecular weight of 2000 Da is required for Poly-PEG-modified surfaces. Cell association of PEGylated AuNRs further confirms that a low molecular weight of Mono-PEG is sufficient to achieve low-fouling properties. This study provides an insight and general guidance into the engineering of low-fouling surfaces by the appropriate choice based on the PEG monodispersity and/or molecular weights.
Publisher: American Chemical Society (ACS)
Date: 30-09-2021
Publisher: American Chemical Society (ACS)
Date: 22-03-2021
Publisher: American Chemical Society (ACS)
Date: 28-03-2022
DOI: 10.1021/ACS.ACCOUNTS.2C00068
Abstract: Supramolecular assembly is commonly driven by noncovalent interactions (e.g., hydrogen bonding, electrostatic, hydrophobic, and aromatic interactions) and plays a predominant role in multidisciplinary research areas ranging from materials design to molecular biology. Understanding these noncovalent interactions at the molecular level is important for studying and designing supramolecular assemblies in chemical and biological systems. Cation-π interactions, initially found through their influence on protein structure, are generally formed between electron-rich π systems and cations (mainly alkali, alkaline-earth metals, and ammonium). Cation-π interactions play an essential role in many biological systems and processes, such as potassium channels, nicotinic acetylcholine receptors, biomolecular recognition and assembly, and the stabilization and function of biomacromolecular structures. Early fundamental studies on cation-π interactions primarily focused on computational calculations, protein crystal structures, and gas- and solid-phase experiments. With the more recent development of spectroscopic and nanomechanical techniques, cation-π interactions can be characterized directly in aqueous media, offering opportunities for the rational manipulation and incorporation of cation-π interactions into the design of supramolecular assemblies. In 2012, we reported the essential role of cation-π interactions in the strong underwater adhesion of Asian green mussel foot proteins deficient in l-3,4-dihydroxyphenylalanine (DOPA) via direct molecular force measurements. In another study in 2013, we reported the experimental quantification and nanomechanics of cation-π interactions of various cations and π electron systems in aqueous solutions using a surface forces apparatus (SFA).Over the past decade, much progress has been achieved in probing cation-π interactions in aqueous solutions, their impact on the underwater adhesion and cohesion of different soft materials, and the fabrication of functional materials driven by cation-π interactions, including surface coatings, complex coacervates, and hydrogels. These studies have demonstrated cation-π interactions as an important driving force for engineering functional materials. Nevertheless, compared to other noncovalent interactions, cation-π interactions are relatively less investigated and underappreciated in governing the structure and function of supramolecular assemblies. Therefore, it is imperative to provide a detailed overview of recent advances in understanding of cation-π interactions for supramolecular assembly, and how these interactions can be used to direct supramolecular assembly for various applications (e.g., underwater adhesion). In this Account, we present very recent advances in probing and applying cation-π interactions for mussel-inspired supramolecular assemblies as well as their structural and functional characteristics. Particular attention is paid to experimental characterization techniques for quantifying cation-π interactions in aqueous solutions. Moreover, the parameters responsible for modulating the strengths of cation-π interactions are discussed. This Account provides useful insights into the design and engineering of smart materials based on cation-π interactions.
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2CC04938D
Abstract: Polyethylene glycol (PEG) has been widely used for modifying surfaces to reduce non-specific interactions with biomolecules, microorganisms, and cells. Herein, we report a sticktight-inspired PEGylation strategy to fabricate low-fouling coatings. The influence of PEG molecular architectures on the PEG density and biological adhesion were studied. Notably, an increase in the number of arms resulted in improved surface PEGylation and an improved antifouling ability against the adhesion of proteins, mammalian cells and bacteria. The molecular architecture-dependent PEGylation strategy is an attractive approach for developing advanced low-fouling coatings.
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2CC01874H
Abstract: Confined sono-polymerization is developed to prepare poly(ethylene glycol) nanoparticles within water-in-oil microemulsions for targeted delivery.
Publisher: American Chemical Society (ACS)
Date: 11-10-2023
Publisher: American Chemical Society (ACS)
Date: 05-11-2020
Publisher: Elsevier BV
Date: 04-2022
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1PY00947H
Abstract: The anticancer drug of Bortezomib conjugated onto catechol-modified bottlebrush block copolymers can be intracellularly released owing to the pH-responsive behavior, resulting in considerable cell death and tumor growth inhibition.
Publisher: American Chemical Society (ACS)
Date: 13-01-2021
Publisher: American Chemical Society (ACS)
Date: 23-10-2023
No related grants have been discovered for Peiyu Zhang.