ORCID Profile
0000-0001-9880-8478
Current Organisation
University of Technology Sydney
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Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4LC00751D
Abstract: A highly flexible GMR-based microfluidic analytic device was demonstrated to analyze droplets of various dimensions and different concentrations of magnetic contents.
Publisher: Springer Science and Business Media LLC
Date: 30-08-2013
DOI: 10.1038/SREP02548
Publisher: Wiley
Date: 09-2016
Publisher: American Chemical Society (ACS)
Date: 24-08-2023
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8SC01023D
Abstract: Ligand competition directs heterogeneous bio-chemistry surface and self-assembly for upconversion nanoparticles.
Publisher: Springer Science and Business Media LLC
Date: 10-04-2015
Publisher: American Chemical Society (ACS)
Date: 14-02-2018
DOI: 10.1021/ACS.ANALCHEM.7B05341
Abstract: Upconversion nanoparticles (UCNPs) are new optical probes for biological applications. For specific biomolecular recognition to be realized for diagnosis and imaging, the key lies in developing a stable and easy-to-use bioconjugation method for antibody modification. Current methods are not yet satisfactory regarding conjugation time, stability, and binding efficiency. Here, we report a facile and high-yield approach based on a bispecific antibody (BsAb) free of chemical reaction steps. One end of the BsAb is designed to recognize methoxy polyethylene glycol-coated UCNPs, and the other end of the BsAb is designed to recognize the cancer antigen biomarker. Through simple vortexing, BsAb-UCNP nanoprobes form within 30 min and show higher (up to 54%) association to the target than that of the traditional UCNP nanoprobes in the ELISA-like assay. We further demonstrate its successful binding to the cancer cells with high efficiency and specificity for background-free fluorescence imaging under near-infrared excitation. This method suggests a general approach broadly suitable for functionalizing a range of nanoparticles to specifically target biomolecules.
Publisher: Elsevier BV
Date: 07-2022
DOI: 10.1016/J.ACTBIO.2022.05.029
Abstract: The central nervous system (CNS) is protected by the blood-brain barrier (BBB), which acts as a physical barrier to regulate and prevent the uptake of endogenous metabolites and xenobiotics. However, the BBB prevents most non-lipophilic drugs from reaching the CNS following systematic administration. Therefore, there is considerable interest in identifying drug carriers that can maintain the biostability of therapeutic molecules and target their transport across the BBB. In this regard, upconversion nanoparticles (UCNPs) have become popular as a nanoparticle-based solution to this problem, with the additional benefit that they display unique properties for in vivo visualization. The majority of studies to date have explored basic spherical UCNPs for drug delivery applications. However, the biophysical properties of UCNPs, cell uptake and BBB transport have not been thoroughly investigated. In this study, we described a one-pot seed-mediated approach to precisely control longitudinal growth to produce bright UCNPs with various aspect ratios. We have systematically evaluated the effects of the physical aspect ratios and PEGylation of UCNPs on cellular uptake in different cell lines and an in vivo zebrafish model. We found that PEGylated the original UCNPs can enhance their biostability and cell uptake capacity. We identify an optimal aspect ratio for UCNP uptake into several different types of cultured cells, finding that this is generally in the ratio of 2 (length/width). This data provides a crucial clue for further optimizing UCNPs as a drug carrier to deliver therapeutic agents into the CNS. STATEMENT OF SIGNIFICANCE: The central nervous system (CNS) is protected by the blood-brain barrier (BBB), which acts as a highly selective semipermeable barrier of endothelial cells to regulate and prevent the uptake of toxins and pathogens. However, the BBB prevents most non-lipophilic drugs from reaching the CNS following systematic administration. The proposed research is significant because identifying the aspect ratio of drug carriers that maintains the biostability of therapeutic molecules and targets their transport across the blood-brain barrier (BBB) is crucial for designing an efficient drug delivery system. Therefore, this research provides a vital clue for further optimizing UCNPs as drug carriers to deliver therapeutic molecules into the brain.
Publisher: Elsevier BV
Date: 05-2018
Publisher: Wiley
Date: 24-06-2019
Abstract: Optical nanomaterials have been widely used in anticounterfeiting applications. There have been significant developments powered by recent advances in material science, printing technologies, and the availability of smartphone-based decoding technology. Recent progress in this field is surveyed, including the availability of optical reflection, absorption, scattering, and luminescent nanoparticles. It is demonstrated that advances in the design and synthesis of lanthanide-doped upconversion nanoparticles will lead to the next generation of anticounterfeiting technologies. Their tunable optical properties and optical responses to a range of external stimuli allow high-security level information encoding. Challenges in the scale-up synthesis of nanomaterials, engineering of assessorial devices for smart-phone-based decryption, and alignment to the potential markets which will lead to new directions for research, are discussed.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0LC00431F
Abstract: Approaches, challenges and promising opportunities towards decoding the complexity of extracellular vesicle heterogeneity are discussed.
Publisher: Springer Science and Business Media LLC
Date: 05-03-2015
DOI: 10.1038/SREP08787
Abstract: Topological magnetic states, such as chiral skyrmions, are of great scientific interest and show huge potential for novel spintronics applications, provided their topological charges can be fully controlled. So far skyrmionic textures have been observed in noncentrosymmetric crystalline materials with low symmetry and at low temperatures. We propose theoretically and demonstrate experimentally the design of spin textures with topological charge densities that can be tailored at ambient temperatures. Tuning the interlayer coupling in vertically stacked nanopatterned magnetic heterostructures, such as a model system of a Co/Pd multilayer coupled to Permalloy, the in-plane non-collinear spin texture of one layer can be imprinted into the out-of-plane magnetised material. We observe distinct spin textures, e.g. vortices, magnetic swirls with tunable opening angle, donut states and skyrmion core configurations. We show that applying a small magnetic field, a reliable switching between topologically distinct textures can be achieved at remanence.
Publisher: MDPI AG
Date: 27-05-2015
DOI: 10.3390/S150612526
Publisher: AIP Publishing
Date: 24-03-2023
DOI: 10.1063/5.0149799
Publisher: Wiley
Date: 02-2015
Publisher: American Chemical Society (ACS)
Date: 29-10-2021
Abstract: Microrobots can expand our abilities to access remote, confined, and enclosed spaces. Their potential applications inside our body are obvious,
Publisher: American Chemical Society (ACS)
Date: 13-12-2017
DOI: 10.1021/ACSSENSORS.7B00700
Abstract: Droplet-based high throughput biomolecular screening and combinatorial synthesis entail a viable indexing strategy to be developed for the identification of each microreactor. Here, we propose a novel indexing scheme based on the generation of droplet sequences on demand to form unique encoding droplet chains in fluidic networks. These codes are represented by multiunit and multilevel droplets packages, with each code unit possessing several distinct signal levels, potentially allowing large encoding capacity. For proof of concept, we use magnetic nanoparticles as the encoding material and a giant magnetoresistance (GMR) sensor-based active sorting system supplemented with an optical detector to generate and decode the sequence of one exemplar s le droplet reactor and a 4-unit quaternary magnetic code. The indexing capacity offered by 4-unit multilevel codes with this indexing strategy is estimated to exceed 10
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0LC00848F
Abstract: The stray magnetic fields of hierarchically-assembled magnetic beads are utilised to code and decode information for multiplexed kinetic assays.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4LC01160K
Abstract: A magnetofluidic platform with integrated GMR sensors is demonstrated for on-demand facile generation and high-throughput real-time decoding of droplet barcodes.
Publisher: American Chemical Society (ACS)
Date: 08-12-2021
DOI: 10.1021/ACSSENSORS.1C02101
Abstract: Upconversion nanoparticles are a class of luminescent materials that convert longer-wavelength near-infrared photons into visible and ultraviolet emissions. They can respond to various external stimuli, which underpins many opportunities for developing the next generation of sensing technologies. In this perspective, the unique stimuli-responsive properties of upconverting nanoparticles are introduced, and their recent implementations in sensing are summarized. Promising material development strategies for enhancing the key sensing merits, including intrinsic sensitivity, biocompatibility and modality, are identified and discussed. The outlooks on future technological developments, novel sensing concepts, and applications of nanoscale upconversion sensors are provided.
Publisher: American Chemical Society (ACS)
Date: 02-05-0018
DOI: 10.1021/ACS.NANOLETT.2C00724
Abstract: Cancer-derived small extracellular vesicles (sEVs) are potential circulating biomarkers in liquid biopsies. However, their small sizes, low abundance, and heterogeneity in molecular makeups pose major technical challenges for detecting and characterizing them quantitatively. Here, we demonstrate a single-sEV enumeration platform using lanthanide-doped upconversion nanoparticles (UCNPs). Taking advantage of the unique optical properties of UCNPs and the background-eliminating property of total internal reflection fluorescence (TIRF) imaging technique, a single-sEV assay recorded a limit of detection 1.8 × 10
Publisher: Wiley
Date: 05-10-2012
Abstract: The first highly stretchable and sensitive spin valve sensor on elastomeric membranes are demonstrated. The sensor elements exhibit stable GMR behavior up to tensile strains of 29% in in situ stretching experiments and show no fatigue over 500 loading cycles. This remarkable stretchability is achieved by a predetermined periodic fracture mechanism that creates a meander-like pattern upon stretching.
Publisher: Wiley
Date: 07-2015
Publisher: Springer Science and Business Media LLC
Date: 18-06-2018
Publisher: Wiley
Date: 22-10-2014
Abstract: A lab-on-chip device is demonstrated for probing the electrochemical kinetics, electrical properties, and structure integrity of a single Si rolled-up tube as the anode in lithium-ion batteries. Cyclic voltammetry of the tube exhibits better-resolved peaks than of the planar film due to the enhanced diffusion. The tube is wrinkled after cycling. The tube could be used as a promising ultra-microelectrode for other voltammetry research.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8CC04200D
Abstract: We report a facile approach of using DNA molecules as switches to selectively activate silica coating onto specific facets of upconversion nanoparticles.
Publisher: American Chemical Society (ACS)
Date: 04-05-2023
Publisher: American Chemical Society (ACS)
Date: 05-11-2019
Publisher: Wiley
Date: 23-06-2021
DOI: 10.1002/VIW.20200076
Abstract: Multidimensional or multiplex bioanalysis represents a crucial approach to improve diagnostic precision, increase assay throughput and advance fundamental discoveries in analytical industry, life science, and nanomedicine. Along this line, bio‐interfacing magnetic particles have been playing an important role. Fully exploiting the properties of magnetic particles is the key to tailoring recent technology development for better translational outcomes. In this mini‐review, typical magneto‐physical dimensions of magnetic particles are introduced. Recent progress of implementing these dimensions with advanced sensor and actuator technologies in multiplex bioanalysis is discussed. Outlooks on potential biomedical applications and challenges are provided.
Publisher: Wiley
Date: 18-07-2016
Abstract: Information tagging and processing are vital in information-intensive applications, e.g., telecommunication and high-throughput drug screening. Magnetic suspension array technology may offer intrinsic advantages to screening applications by enabling high distinguishability, the ease of code generation, and the feasibility of fast code readout, though the practical applicability of magnetic suspension array technology remains h ered by the lack of quality administration of encoded microcarriers. Here, a logic-controlled microfluidic system enabling controlled synthesis of magnetic suspension arrays in multiphase flow networks is realized. The smart and compact system offers a practical solution for the quality administration and screening of encoded magnetic microcarriers and addresses the universal need of process control for synthesis in microfluidic networks, i.e., on-demand creation of droplet templates for high information capacity. The demonstration of magnetic suspension array technology enabled by magnetic in-flow cytometry opens the avenue toward point-of-care multiplexed bead-based assays, clinical diagnostics, and drug discovery.
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9LC00872A
Abstract: Gradient-sized spheroids can be simultaneously generated on a single chip using a liquid-dome method assisted by the surface tension. The facile method can be used for investigation of the size-dependent behaviors of spheroids in biomedical research.
Publisher: IEEE
Date: 05-2015
Publisher: Wiley
Date: 06-05-2015
Abstract: A flexible diagnostic platform is realized and its performance is demonstrated for early detection of avian influenza virus (AIV) subtype H1N1 DNA sequences. The key component of the platform is high-performance biosensors based on high output currents and low power dissipation Si nanowire field effect transistors (SiNW-FETs) fabricated on flexible 100 μm thick polyimide foils. The devices on a polymeric support are about ten times lighter compared to their rigid counterparts on Si wafers and can be prepared on large areas. While the latter potentially allows reducing the fabrication costs per device, the former makes them cost efficient for high-volume delivery to medical institutions in, e.g., developing countries. The flexible devices withstand bending down to a 7.5 mm radius and do not degrade in performance even after 1000 consecutive bending cycles. In addition to these remarkable mechanical properties, on the analytic side, the diagnostic platform allows fast detection of specific DNA sequences of AIV subtype H1N1 with a limit of detection of 40 × 10(-12) m within 30 min suggesting its suitability for early stage disease diagnosis.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7LC00026J
Abstract: A review highlighting the historical basis, routes and roadmap of the development of magnetic biosensing platform technologies.
Publisher: American Chemical Society (ACS)
Date: 18-10-2018
DOI: 10.1021/ACS.ANALCHEM.8B04330
Abstract: Paper-based lateral flow assays, though being low-cost and widely used for rapid in vitro diagnostics, are indicative and do not provide sufficient sensitivity for the detection and quantification of low abundant biomarkers for early stage cancer diagnosis. Here, we design a compact device to create a focused illumination spot with high irradiance, which activates a range of highly doped 50 nm upconversion nanoparticles (UCNPs) to produce orders of magnitude brighter emissions. The device employs a very low-cost laser diode, simplified excitation, and collection optics and permits a mobile phone camera to record the results. Using highly erbium ion (Er
Publisher: Wiley
Date: 10-07-2017
Abstract: A novel realization of microtubular direct methanol fuel cells ( µ DMFC) with ultrahigh power output is reported by using “rolled‐up” nanotechnology. The microtube (Pt‐RuO 2 ‐RUMT) is prepared by rolling up Ru 2 O layers coated with magnetron‐sputtered Pt nanoparticles (cat‐NPs). The µ DMFC is fabricated by embedding the tube in a fluidic cell. The footprint of per tube is as small as 1.5 × 10 −4 cm 2 . A power density of ≈257 mW cm −2 is obtained, which is three orders of magnitude higher than the present microsized DFMCs. Atomic layer deposition technique is applied to alleviate the methanol crossover as well as improve stability of the tube, sustaining electrolyte flow for days. A laminar flow driven mechanism is proposed, and the kinetics of the fuel oxidation depends on a linear‐diffusion‐controlled process. The electrocatalytic performance on anode and cathode is studied by scanning both sides of the tube wall as an ex situ working electrode, respectively. This prototype µ DFMC is extremely interesting for integration with micro‐ and nanoelectronics systems.
Publisher: Wiley
Date: 14-01-2015
Publisher: AIP Publishing
Date: 19-07-2021
DOI: 10.1063/5.0056067
Abstract: Magnetic tweezers are crucial for single-molecule and atomic characterization and biomedical isolation of microparticle carriers. The trapping component of magnetic tweezing can be reliant on a magnetic potential well that can confine the relevant species to a localized region. Here, we report that magnetic microparticles with tailored anisotropy can transition from localized off-axis gyration to large-area locomotion in a rotating magnetic trap. The microparticles, consisting of assemblies of magnetic cores, are observed to either rotate about its structural geometric center or gyrate about one of the magnetic cores and the switching of which can be modulated by the external field. Raising the magnetic field strength above a threshold, the particles can go beyond the traditional synchronous-rotation and asynchronous-oscillation modes and into a scenario of large-area circular motion. This results in peculiar retrograde locomotion related to the magnetization maxima of the microparticle. Our finding suggests the important role of the microparticle's magnetic morphology in the controlled transport of microparticles and developing smart micro-actuators and micro-robot devices.
Location: Germany
No related grants have been discovered for Gungun Lin.