ORCID Profile
0000-0002-0605-5745
Current Organisations
Georgia Institute of Technology
,
Georgia Tech Research Institute
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Research Topics
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Top 5 Research Topics
ANZSRC Field of Research (FoR)
Nanophotonics | Medical biotechnology diagnostics (incl. biosensors) | Inorganic materials (incl. nanomaterials) | Optical properties of materials | Analytical Chemistry | Sensor technology (incl. chemical aspects) | Quantum technologies | Optical Properties of Materials | Instrumental Methods (excl. Immunological and Bioassay Methods) | Macromolecular and Materials Chemistry | Immunological and Bioassay Methods | Biocatalysis and enzyme technology | Medical Biotechnology Diagnostics (incl. Biosensors) | Quantum physics | Macromolecular and materials chemistry | Biological physics
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in Technology | Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Physical Sciences | Expanding Knowledge in Engineering |
Related Links
Publications
Activation of the surface dark-layer to enhance upconversion in a thermal field
Publisher: Springer Science and Business Media LLC
Date: 12-02-2018
Topological nanophotonics for photoluminescence control
Publisher: Walter de Gruyter GmbH
Date: 15-09-2020
Abstract: Rare-earth-doped nanocrystals are emerging light sources that can produce tunable emissions in colours and lifetimes, which has been typically achieved in chemistry and material science. However, one important optical challenge – polarization of photoluminescence – remains largely out of control by chemistry methods. Control over photoluminescence polarization can be gained via coupling of emitters to resonant nanostructures such as optical antennas and metasurfaces. However, the resulting polarization is typically sensitive to position disorder of emitters, which is difficult to mitigate. Recently, new classes of disorder-immune optical systems have been explored within the framework of topological photonics. Here we explore disorder-robust topological arrays of Mie-resonant nanoparticles for polarization control of photoluminescence of nanocrystals. We demonstrate polarized emission from rare-earth-doped nanocrystals governed by photonic topological edge states supported by zigzag arrays of dielectric resonators. We verify the topological origin of polarized photoluminescence by comparing emission from nanoparticles coupled to topologically trivial and nontrivial arrays of nanoresonators. We expect that our results may open a new direction in the study of topology-enable emission properties of topological edge states in many photonic systems.
Amplified stimulated emission in upconversion nanoparticles for super-resolution nanoscopy
Publisher: Springer Science and Business Media LLC
Date: 22-02-2017
DOI: 10.1038/NATURE21366
Abstract: Lanthanide-doped glasses and crystals are attractive for laser applications because the metastable energy levels of the trivalent lanthanide ions facilitate the establishment of population inversion and lified stimulated emission at relatively low pump power. At the nanometre scale, lanthanide-doped upconversion nanoparticles (UCNPs) can now be made with precisely controlled phase, dimension and doping level. When excited in the near-infrared, these UCNPs emit stable, bright visible luminescence at a variety of selectable wavelengths, with single-nanoparticle sensitivity, which makes them suitable for advanced luminescence microscopy applications. Here we show that UCNPs doped with high concentrations of thulium ions (Tm
Bispecific Antibody-Functionalized Upconversion Nanoprobe
Publisher: American Chemical Society (ACS)
Date: 14-02-2018
DOI: 10.1021/ACS.ANALCHEM.7B05341
Abstract: Upconversion nanoparticles (UCNPs) are new optical probes for biological applications. For specific biomolecular recognition to be realized for diagnosis and imaging, the key lies in developing a stable and easy-to-use bioconjugation method for antibody modification. Current methods are not yet satisfactory regarding conjugation time, stability, and binding efficiency. Here, we report a facile and high-yield approach based on a bispecific antibody (BsAb) free of chemical reaction steps. One end of the BsAb is designed to recognize methoxy polyethylene glycol-coated UCNPs, and the other end of the BsAb is designed to recognize the cancer antigen biomarker. Through simple vortexing, BsAb-UCNP nanoprobes form within 30 min and show higher (up to 54%) association to the target than that of the traditional UCNP nanoprobes in the ELISA-like assay. We further demonstrate its successful binding to the cancer cells with high efficiency and specificity for background-free fluorescence imaging under near-infrared excitation. This method suggests a general approach broadly suitable for functionalizing a range of nanoparticles to specifically target biomolecules.
Bone Disease Imaging through the Near-Infrared-II Window
Publisher: Research Square Platform LLC
Date: 02-03-2023
DOI: 10.21203/RS.3.RS-2582295/V1
Abstract: Bone health related skeletal disorders are commonly diagnosed by X-ray imaging, but the radiation limits its use. Light excitation and optical imaging through the near-infrared-II window (NIR-II, 1000–1700 nm) can penetrate deep tissues without radiation risk, but the targeting of contrast agent is non-specific. Here, we report that lanthanide-doped nanocrystals can be passively transported by endothelial cells and macrophages from the blood vessels into bone marrow microenvironment. We found that this bone targeting scheme can be effective for longer than two months. We therefore developed an intravital 3D and high-resolution planar imaging instrumentation for bone disease diagnosis. We demonstrated the regular monitoring of 1 mm bone defects for 11 days in NIR-II window, with spatial resolution similar to X-ray imaging result, but more flexible use in prognosis. Moreover, the passive targeting can be used to reveal the early onset inflammation at the joints as the synovitis in the early stage of rheumatoid arthritis. Furthermore, the proposed method is comparable to micro computed tomography (µCT) in recognizing symptoms of osteoarthritis, including the mild hyperostosis in femur which is ~ 100 µm thicker than normal, and the growth of millimeter-scale osteophyte in the knee joint, which further proves the power and universality of our approach.
Nanorods with multidimensional optical information beyond the diffraction limit
Publisher: Springer Science and Business Media LLC
Date: 27-11-2020
DOI: 10.1038/S41467-020-19952-X
Abstract: Precise design and fabrication of heterogeneous nanostructures will enable nanoscale devices to integrate multiple desirable functionalities. But due to the diffraction limit (~200 nm), the optical uniformity and ersity within the heterogeneous functional nanostructures are hardly controlled and characterized. Here, we report a set of heterogeneous nanorods each optically active section has its unique nonlinear response to donut-shaped illumination, so that one can discern each section with super-resolution. To achieve this, we first realize an approach of highly controlled epitaxial growth and produce a range of heterogeneous structures. Each section along the nanorod structure displays tunable upconversion emissions, in four optical dimensions, including color, lifetime, excitation wavelength, and power dependency. Moreover, we demonstrate a 210 nm single nanorod as an extremely small polychromatic light source for the on-demand generation of RGB photonic emissions. This work benchmarks our ability toward the full control of sub-diffraction-limit optical ersities of single heterogeneous nanoparticles.
Emerging role of machine learning in light-matter interaction
Publisher: Springer Science and Business Media LLC
Date: 11-09-2019
DOI: 10.1038/S41377-019-0192-4
Abstract: Machine learning has provided a huge wave of innovation in multiple fields, including computer vision, medical diagnosis, life sciences, molecular design, and instrumental development. This perspective focuses on the implementation of machine learning in dealing with light-matter interaction, which governs those fields involving materials discovery, optical characterizations, and photonics technologies. We highlight the role of machine learning in accelerating technology development and boosting scientific innovation in the aforementioned aspects. We provide future directions for advanced computing techniques via multidisciplinary efforts that can help to transform optical materials into imaging probes, information carriers and photonics devices.
Significant Enhancement of the Upconversion Emission in Highly Er3+‐Doped Nanoparticles at Cryogenic Temperatures
Publisher: Wiley
Date: 10-01-2023
Abstract: Relatively low efficiency is the bottleneck for the application of lanthanide‐doped upconversion nanoparticles (UCNPs). The high‐level doping strategy realized in recent years has not improved the efficiency as much as expected. It is argued that cross relaxation (CR) is not detrimental to upconversion. Here we combine theoretical simulation and spectroscopy to elucidate the role of CR in upconversion process of Er 3+ highly doped (HD) UCNPs. It is found that if CR is purposively suppressed, upconversion efficiency can be significantly improved. Specifically, we demonstrate experimentally that inhibition of CR by introducing cryogenic environment (40 K) enhances upconversion emission by more than two orders of magnitude. This work not only elucidates the nature of CR and its non‐negligible adverse effects, but also provides a new perspective for improving upconversion efficiency. The result can be directly applied to cryogenic imaging and wide range temperature sensing.
Metasurface-Controlled Photonic Rashba Effect for Upconversion Photoluminescence
Publisher: American Chemical Society (ACS)
Date: 02-03-2023
Stratified Disk Microrobots with Dynamic Maneuverability and Proton-Activatable Luminescence for in Vivo Imaging
Publisher: American Chemical Society (ACS)
Date: 29-10-2021
Abstract: Microrobots can expand our abilities to access remote, confined, and enclosed spaces. Their potential applications inside our body are obvious,
Spatiotemporally mapping temperature dynamics of lysosomes and mitochondria using cascade organelle-targeting upconversion nanoparticles
Publisher: Proceedings of the National Academy of Sciences
Date: 02-11-2022
Abstract: The intracellular metabolism of organelles, like lysosomes and mitochondria, is highly coordinated spatiotemporally and functionally. The activities of lysosomal enzymes significantly rely on the cytoplasmic temperature, and heat is constantly released by mitochondria as the byproduct of adenosine triphosphate (ATP) generation during active metabolism. Here, we developed temperature-sensitive LysoDots and MitoDots to monitor the in situ thermal dynamics of lysosomes and mitochondria. The design is based on upconversion nanoparticles (UCNPs) with high-density surface modifications to achieve the exceptionally high sensitivity of 2.7% K −1 and low uncertainty of 0.8 K for nanothermometry to be used in living cells. We show the measurement is independent of the ion concentrations and pH values. With Ca 2+ ion shock, the temperatures of both lysosomes and mitochondria increased by ∼2 to 4 °C. Intriguingly, with chloroquine (CQ) treatment, the lysosomal temperature was observed to decrease by up to ∼3 °C, while mitochondria remained relatively stable. Lastly, with oxidative phosphorylation inhibitor treatment, we observed an ∼3 to 7 °C temperature increase and a thermal transition from mitochondria to lysosomes. These observations indicate different metabolic pathways and thermal transitions between lysosomes and mitochondria inside HeLa cells. The nanothermometry probes provide a powerful tool for multimodality functional imaging of subcellular organelles and interactions with high spatial, temporal, and thermal dynamics resolutions.
Single-particle spectroscopy for functional nanomaterials
Publisher: Springer Science and Business Media LLC
Date: 04-03-2020
Advances and challenges for fluorescence nanothermometry
Publisher: Springer Science and Business Media LLC
Date: 28-09-2020
Direct cation exchange of surface ligand capped upconversion nanocrystals to produce strong luminescence
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8CC04924F
Abstract: We develop a facile and rapid cation exchange method for upconversion nanocrystals (UCNCs) without removing surface ligands.
Bone disease imaging through the near-infrared-II window
Publisher: Springer Science and Business Media LLC
Date: 09-10-2023
Enhancing Hybrid Upconversion Nanosystems via Synergistic Effects of Moiety Engineered NIR Dyes
Publisher: American Chemical Society (ACS)
Date: 15-11-2021
DOI: 10.1021/ACS.NANOLETT.1C02391
Abstract: Hybrid upconversion nanosystems have been reported to improve the low absorption efficiency of lanthanide-doped upconversion nanoparticles (UCNPs). However, the low quantum yield and poor photostability of NIR dyes pose challenges for practical uses. Here, we introduce a bulky moiety, 4-(1,2,2-triphenylvinyl)-1,1'-biphenyl (TPEO), to enhance its quantum yield by suppressing the bond rotation and improve the stability by deactivating the photoinduced oxidization. Compared with the conventional IR806, the formed NIR dye, TPEO-Cy, has been characterized to deliver three times higher quantum yield and seven times better photostability. Moreover, we take advantage of the strong affinity of sulfonate chains on the TPEO-Cy to bind to the surface of UCNPs. Taking together the synergistic effect, we have achieved a 242-fold upconversion emission enhancement over the benchmark of IR806-sensitized system and an ∼800 000-fold increase than the bare UCNPs. Our design of the NIR dyes suggests a new scope to search for more efficient upconversion nanohybrids.
Enhanced energy transfer in heterogeneous nanocrystals for near infrared upconversion photocurrent generation
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7NR07010A
Abstract: A heterogeneous NaYF 4 :Yb,Tm@ZnO nanoparticle with an epitaxial interface is prepared, and it possesses an enhanced upconversion emission intensity and an excellent photocurrent response.
Future and challenges for hybrid upconversion nanosystems
Publisher: Springer Science and Business Media LLC
Date: 28-10-2019
Emission stability and reversibility of upconversion nanocrystals
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6TC02990F
Abstract: We report the emission stability and reversibility of NaYF 4 :Yb 3+ ,Er 3+ core and core–shell nanocrystals at different temperatures and pH values.
Upconversion nanoparticles coated with molecularly imprinted polymers for specific sensing
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0DT03555F
Abstract: The development of fluorescent sensors based on lanthanide-doped luminescent nanoparticles has increased their application in biomarker detection.
Anisotropic surface quenching of upconversion nanoparticles
Publisher: Research Square Platform LLC
Date: 21-06-2023
DOI: 10.21203/RS.3.RS-3065166/V1
Abstract: Shape anisotropy at the nanoscale has emerged as a potent way to access new properties and functionalities of luminescent materials. While the controlled synthesis and precise characterization of the anisotropy-dependent properties are important challenges in nanoscience, success has recently been achieved in lanthanides doped nanoparticles. In particular, the lanthanides doped upconversion nanoparticles demonstrate an anisotropy-enabled set of unique and fine-tuned optical properties at the single nanoparticle level. However, it is still unclear how their optical properties relate to the behavior of surface ligands, a factor considered as a significant contribution to energy transfer in nanoparticles, thereby determining emission property. Here, we report a method that employs the splitting spectroscopy of single nanoparticles to reveal the surface ligands participated transition process of lanthanides, leading to a previously unknown exploration of quenching selectivity. We design a nanoplate to correlate its splitting transition intensity ratio with quenching selectivity, in which two polarization orthogonal splitting dipoles will interact with surface ligands selectively on the orthogonal facets. We verify this by implementing single dimensional particle growth to finely tune the quenching selectivity in a series of nanoplates and nanorods with controlled anisotropic aspect ratio. These findings offer insights into the way the surface regulates the ionic electron transition and contribute to the development of selective emissions in anisotropic nanoparticles.
Quantitative Lateral Flow Strip Sensor Using Highly Doped Upconversion Nanoparticles
Publisher: American Chemical Society (ACS)
Date: 18-10-2018
DOI: 10.1021/ACS.ANALCHEM.8B04330
Abstract: Paper-based lateral flow assays, though being low-cost and widely used for rapid in vitro diagnostics, are indicative and do not provide sufficient sensitivity for the detection and quantification of low abundant biomarkers for early stage cancer diagnosis. Here, we design a compact device to create a focused illumination spot with high irradiance, which activates a range of highly doped 50 nm upconversion nanoparticles (UCNPs) to produce orders of magnitude brighter emissions. The device employs a very low-cost laser diode, simplified excitation, and collection optics and permits a mobile phone camera to record the results. Using highly erbium ion (Er
Boosting NIR-driven photocatalytic water splitting by constructing 2D/3D epitaxial heterostructures
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9TA02780G
Abstract: YF 3 :Yb, Tm@BiOCl possesses epitaxial heterostructure, which can quantitatively activate multiple energy transfer channels including excited-state energy transfer and fluorescence reabsorption, and then promote the NIR-driven photocatalytic properties.
Lanthanide-activated nanoconstructs for optical multiplexing
Publisher: Elsevier BV
Date: 07-2020
Thermally enhanced NIR–NIR anti-Stokes emission in rare earth doped nanocrystals
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9NR03041G
Abstract: Surface phonons enhancing the one-photon anti-Stokes fluorescence has been demonstrated in rare earth doped nanocrystals.
Author Correction: High-sensitivity imaging of time-domain near-infrared light transducer
Publisher: Springer Science and Business Media LLC
Date: 09-06-2021
On-Chip Mirror Enhanced Multiphoton Upconversion Super-Resolution Microscopy
Publisher: American Chemical Society (ACS)
Date: 05-06-2023
Stable and Highly Efficient Antibody–Nanoparticles Conjugation
Publisher: American Chemical Society (ACS)
Date: 20-05-2021
Advances in highly doped upconversion nanoparticles
Publisher: Springer Science and Business Media LLC
Date: 20-06-2018
DOI: 10.1038/S41467-018-04813-5
Abstract: Lanthanide-doped upconversion nanoparticles (UCNPs) are capable of converting near-infra-red excitation into visible and ultraviolet emission. Their unique optical properties have advanced a broad range of applications, such as fluorescent microscopy, deep-tissue bioimaging, nanomedicine, optogenetics, security labelling and volumetric display. However, the constraint of concentration quenching on upconversion luminescence has h ered the nanoscience community to develop bright UCNPs with a large number of dopants. This review surveys recent advances in developing highly doped UCNPs, highlights the strategies that bypass the concentration quenching effect, and discusses new optical properties as well as emerging applications enabled by these nanoparticles.
Helix Shape Power-Dependent Properties of Single Upconversion Nanoparticles
Publisher: American Chemical Society (ACS)
Date: 24-01-2020
DOI: 10.1021/ACS.JPCLETT.9B03838
Abstract: Nonblinking, nonbleaching, and superbright single upconversion nanoparticles have been recently discovered with nonlinear power-dependent properties and can be switchable under dual-beam excitations, which are ideal for super-resolution microscopy, single-molecule tracking, and digital assays. Here, we report that the brightness of Nd
Investigating electromagnetically induced transparency spectral lineshape distortion due to non-uniform fields in Rydberg-atom electrometry
Publisher: AIP Publishing
Date: 25-08-2023
DOI: 10.1063/5.0161213
Abstract: We investigate the effects of spatially non-uniform radio-frequency electric (E) field litudes on the spectral line shapes of electromagnetically induced transparency (EIT) signals in Rydberg atomic systems used in electrometry (i.e., the metrology of E-field strengths). Spatially non-uniform fields distort the EIT spectra from that of an ideal case, and understanding this distortion is important in the development of Rydberg atom-based sensors, as these distortions can limit accuracy and sensitivity. To characterize this distortion, we present a model that approximates the atom vapor as multi-layered media and then uses Beer’s law to combine the absorption through its many discrete thin segments. We present a set of expected line distortions caused by various RF electric-field distributions found in practice. This provides an intuitive diagnostic tool for experiments. We compare this model to measured experimental atomic spectra in both two-photon and three-photon excitation schemes in the presence of non-uniform radio-frequency fields. We show that we can accurately model and reproduce the EIT lineshape distortion observed in these experimental data.
Optical Nanomaterials and Enabling Technologies for High‐Security‐Level Anticounterfeiting
Publisher: Wiley
Date: 24-06-2019
Abstract: Optical nanomaterials have been widely used in anticounterfeiting applications. There have been significant developments powered by recent advances in material science, printing technologies, and the availability of smartphone-based decoding technology. Recent progress in this field is surveyed, including the availability of optical reflection, absorption, scattering, and luminescent nanoparticles. It is demonstrated that advances in the design and synthesis of lanthanide-doped upconversion nanoparticles will lead to the next generation of anticounterfeiting technologies. Their tunable optical properties and optical responses to a range of external stimuli allow high-security level information encoding. Challenges in the scale-up synthesis of nanomaterials, engineering of assessorial devices for smart-phone-based decryption, and alignment to the potential markets which will lead to new directions for research, are discussed.
High-sensitivity imaging of time-domain near-infrared light transducer
Publisher: Springer Science and Business Media LLC
Date: 20-05-2019
Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications
Publisher: Wiley
Date: 31-07-2018
Abstract: Half a century after its initial emergence, lanthanide photonics is facing a profound remodeling induced by the upsurge of nanomaterials. Lanthanide-doped nanomaterials hold promise for bioapplications and photonic devices because they ally the unmatched advantages of lanthanide photophysical properties with those arising from large surface-to-volume ratios and quantum confinement that are typical of nanoobjects. Cutting-edge technologies and devices have recently arisen from this association and are in turn promoting nanophotonic materials as essential tools for a deeper understanding of biological mechanisms and related medical diagnosis and therapy, and as crucial building blocks for next-generation photonic devices. Here, the recent progress in the development of nanomaterials, nanotechnologies, and nanodevices for clinical uses and commercial exploitation is reviewed. The candidate nanomaterials with mature synthesis protocols and compelling optical uniqueness are surveyed. The specific fields that are directly driven by lanthanide doped nanomaterials are emphasized, spanning from in vivo imaging and theranostics, micro-/nanoscopic techniques, point-of-care medical testing, forensic fingerprints detection, to micro-LED devices.
Low threshold lasing emissions from a single upconversion nanocrystal
Publisher: Springer Science and Business Media LLC
Date: 12-2020
DOI: 10.1038/S41467-020-19797-4
Abstract: Cross-relaxation among neighboring emitters normally causes self-quenching and limits the brightness of luminescence. However, in nanomaterials, cross-relaxation could be well-controlled and employed for increasing the luminescence efficiency at specific wavelengths. Here we report that cross-relaxation can modulate both the brightness of single upconversion nanoparticles and the threshold to reach population inversion, and both are critical factors in producing the ultra-low threshold lasing emissions in a micro cavity laser. By homogenously coating a 5-μm cavity with a single layer of nanoparticles, we demonstrate that doping Tm 3+ ions at 2% can facilitate the electron accumulation at the intermediate state of 3 H 4 level and efficiently decrease the lasing threshold by more than one order of magnitude. As a result, we demonstrate up-converted lasing emissions with an ultralow threshold of continuous-wave excitation of ~150 W/cm 2 achieved at room temperature. A single nanoparticle can lase with a full width at half-maximum as narrow as ~0.45 nm.
Multiplexed structured illumination super-resolution imaging with lifetime-engineered upconversion nanoparticles
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1NA00765C
Abstract: We report a tailor-made multiplexed super-resolution imaging method using the lifetime fingerprints from luminescent nanoparticles, which can resolve the particles within the diffraction-limited spots and enable higher multiplexing capacity in space.
Optical Fingerprint Classification of Single Upconversion Nanoparticles by Deep Learning
Publisher: American Chemical Society (ACS)
Date: 14-10-2021
Biodegradable Nanoprodrugs: “Delivering” ROS to Cancer Cells for Molecular Dynamic Therapy
Publisher: Wiley
Date: 03-12-2019
Abstract: Biodegradable nanoprodrugs, inheriting the antitumor effects of chemotherapy drugs and overcoming the inevitable drawback of side effects on normal tissues, hold promise as next-generation cancer therapy candidates. Biodegradable nanoprodrugs of transferrin-modified MgO
Quantitatively Monitoring In Situ Mitochondrial Thermal Dynamics by Upconversion Nanoparticles
Publisher: American Chemical Society (ACS)
Date: 06-02-2021
Triplet state brightens upconversion
Publisher: Springer Science and Business Media LLC
Date: 28-06-2018
Publisher Correction: High-sensitivity imaging of time-domain near-infrared light transducer
Publisher: Springer Science and Business Media LLC
Date: 19-06-2019
Nanobarcodes with multidimensional optical information beyond diffraction limit
Publisher: Research Square Platform LLC
Date: 09-07-2020
DOI: 10.21203/RS.3.RS-39284/V1
Abstract: Precise design and fabrication of heterogeneous nanostructures will enable nanoscale devices to integrate multiple desirable functionalities. But due to the diffraction limit (~200 nm), the optical uniformity and ersity within the heterogeneous functional nanostructures are hardly controlled and characterized. Here we report a set of nanobarcodes, each optically active section has its unique nonlinear responses to donut illumination patterns, so that one can discern each unit with super resolution. To achieve this, we first realized an approach of highly controlled epitaxial growth and produced a range of one-dimensional heterogeneous structures. Each section along the nanorod structure display tunable upconversion emissions, in four optically orthogonal dimensions, including colour, lifetime, excitation wavelength, and power dependency. Moreover, we demonstrated a 210 nm single nanorod as the smallest polychromatic light source for the on-demand generation of RGB photonic emissions. Remarkably, within a space of 50 nm, only 1/20th of the excitation wavelength, multiple codes can be successfully coded and decoded in 4 optical dimensions. This precision control enables the fabrication of super capacity geometrical barcodes with theoretical coding capacity up to (24-1)4. This work benchmarks our new ability towards the full control of sub-diffraction-limit optical ersities of single heterogeneous nanoparticles.
Power-Dependent Optimal Concentrations of Tm3+ and Yb3+ in Upconversion Nanoparticles
Publisher: American Chemical Society (ACS)
Date: 08-06-2022
DOI: 10.1021/ACS.JPCLETT.2C01186
Abstract: Lanthanide-doped upconversion nanoparticles (UCNPs) have enabled a broad range of emerging nanophotonics and biophotonics applications. Here, we provide a quantitative guide to the optimum concentrations of Yb
NIR Light-Controlled DNA Nanodevice for Amplified mRNA Imaging and Precise Gene Therapy
Publisher: Research Square Platform LLC
Date: 31-05-2023
DOI: 10.21203/RS.3.RS-2931628/V1
Abstract: Accurately delivering antisense oligonucleotides (ASOs) to tumor cells for gene therapy poses a significant challenge. To address this issue, we develop a NIR light-activable DNA nanodevice to target survivin mRNA and simultaneously release ASOs in tumor cells, which allows high-precision spatiotemporal imaging with high sensitivity and efficient gene therapy. The concept is based on upconversion nanoparticles, which can convert NIR light into UV emissions to activate an entropy-driven DNA walking system that further determines mRNA in tumor cells. The intramolecular toehold-mediated entropy-driven catalytic reaction generates a large amount of Bcl-2 ASOs, which allows accurate delivery of ASOs for gene therapy due to the specific targeting of mRNA in tumor cells. Both in vitro and in vivo results show that the NIR light induced-DNA nanodevice can detect mRNA with high sensitivity by DNA walking lification system and high precision in gene delivery. Moreover, the released ASOs from DNA walking system deregulate the expression of Bcl-2 anti-apoptosis protein and induce tumor cell apoptosis, thereby suppressing tumor growth without a transfection reagent. The NIR-light-controlled DNA nanodevice holds great potential for precise gene therapy in clinical applications.
High Spatial and Temporal Resolution NIR-IIb Gastrointestinal Imaging in Mice
Publisher: American Chemical Society (ACS)
Date: 24-03-2022
DOI: 10.1021/ACS.NANOLETT.1C04909
Abstract: Conventional biomedical imaging modalities, including endoscopy, X-rays, and magnetic resonance, are invasive and insufficient in spatial and temporal resolutions for gastrointestinal (GI) tract imaging to guide prognosis and therapy. Here we report a noninvasive method based on lanthanide-doped nanocrystals with ∼1530 nm fluorescence in the near-infrared-IIb window (NIR-IIb, 1500-1700 nm). The rational design of nanocrystals have led to an absolute quantum yield (QY) up to 48.6%. Further benefiting from the minimized scattering through the NIR-IIb window, we enhanced the spatial resolution to ∼1 mm in GI tract imaging, which is ∼3 times higher compared with the near-infrared-IIa (NIR-IIa, 1000-1500 nm) method. The approach also realized a high temporal resolution of 8 frames per second thus the moment of mice intestinal peristalsis can be captured. Furthermore, with a light-sheet imaging system, we demonstrated a three-dimensional (3D) imaging on the GI tract. Moreover, we successfully translated these advances to diagnose inflammatory bowel disease.
Ultrasensitive Ratiometric Nanothermometer with Large Dynamic Range and Photostability
Publisher: American Chemical Society (ACS)
Date: 05-11-2019
Preselectable Optical Fingerprints of Heterogeneous Upconversion Nanoparticles
Publisher: American Chemical Society (ACS)
Date: 18-08-2021
Up-conversion hybrid nanomaterials for light- and heat-driven applications
Publisher: Elsevier BV
Date: 08-2021
Triplet fusion upconversion with oxygen resistance in aqueous media
Publisher: American Chemical Society (ACS)
Date: 05-03-2021
Significant Enhancement of the Upconversion Emission in Highly Er3+‐Doped Nanoparticles at Cryogenic Temperatures
Publisher: Wiley
Date: 10-01-2023
Abstract: Relatively low efficiency is the bottleneck for the application of lanthanide‐doped upconversion nanoparticles (UCNPs). The high‐level doping strategy realized in recent years has not improved the efficiency as much as expected. It is argued that cross relaxation (CR) is not detrimental to upconversion. Here we combine theoretical simulation and spectroscopy to elucidate the role of CR in upconversion process of Er 3+ highly doped (HD) UCNPs. It is found that if CR is purposively suppressed, upconversion efficiency can be significantly improved. Specifically, we demonstrate experimentally that inhibition of CR by introducing cryogenic environment (40 K) enhances upconversion emission by more than two orders of magnitude. This work not only elucidates the nature of CR and its non‐negligible adverse effects, but also provides a new perspective for improving upconversion efficiency. The result can be directly applied to cryogenic imaging and wide range temperature sensing.
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