ORCID Profile
0000-0003-1227-1679
Current Organisation
University of Glasgow
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Publisher: Wiley
Date: 10-2018
DOI: 10.1111/JAV.01814
Publisher: Springer Science and Business Media LLC
Date: 09-04-2021
DOI: 10.1038/S41467-021-22344-4
Abstract: There is accumulating evidence that the lower airway microbiota impacts lung health. However, the link between microbial community composition and lung homeostasis remains elusive. We combine licon sequencing and bacterial culturing to characterize the viable bacterial community in 234 longitudinal bronchoalveolar lavage s les from 64 lung transplant recipients and establish links to viral loads, host gene expression, lung function, and transplant health. We find that the lung microbiota post-transplant can be categorized into four distinct compositional states, ‘pneumotypes’. The predominant ‘balanced’ pneumotype is characterized by a erse bacterial community with moderate viral loads, and host gene expression profiles suggesting immune tolerance. The other three pneumotypes are characterized by being either microbiota-depleted, or dominated by potential pathogens, and are linked to increased immune activity, lower respiratory function, and increased risks of infection and rejection. Collectively, our findings establish a link between the lung microbial ecosystem, human lung function, and clinical stability post-transplant.
Publisher: Elsevier BV
Date: 11-2020
Publisher: American Thoracic Society
Date: 15-11-2016
Publisher: Cold Spring Harbor Laboratory
Date: 21-05-2020
DOI: 10.1101/2020.05.21.106211
Abstract: There is accumulating evidence that the lower airway microbiota impacts lung health. However, the link between microbial community composition and lung homeostasis remains elusive. We combined licon sequencing and culturomics to characterize the viable bacterial community in 234 longitudinal bronchoalveolar lavage s les from 64 lung transplant recipients and established links to viral loads, host gene expression, lung function, and transplant health. We find that the lung microbiota post-transplant can be categorized into four distinct compositional states, ‘pneumotypes’. The predominant ‘balanced’ pneumotype was characterized by a erse bacterial community with moderate viral loads, and host gene expression profiles suggesting immune tolerance. The other three pneumotypes were characterized by being either microbiota-depleted, or dominated by potential pathogens, and were linked to increased immune activity, lower respiratory function, and increased risks of infection and rejection. Collectively, our findings establish a link between the lung microbial ecosytem, human lung function, and clinical stability post-transplant.
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Angela Koutsokera.