ORCID Profile
0000-0002-3669-883X
Current Organisations
National Center For Child Health and Development
,
Ashoka Trust for Research in Ecology and the Environment
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Publisher: Public Library of Science (PLoS)
Date: 25-01-2019
Publisher: Public Library of Science (PLoS)
Date: 29-04-2019
Publisher: American Academy of Pediatrics (AAP)
Date: 2019
Abstract: The International Liaison Committee on Resuscitation prioritized to rigorously review the initial fraction of inspired oxygen (Fio2) during resuscitation of newborns. This systematic review and meta-analysis provides the scientific summary of initial Fio2 in term and late preterm newborns (≥35 weeks’ gestation) who receive respiratory support at birth. Medline, Embase, Evidence Based Medicine Reviews, and Cumulative Index to Nursing and Allied Health Literature were searched between January 1, 1980 and August 10, 2018. Studies were selected by pairs of independent reviewers in 2 stages, with a Cohen’s κ of 0.8 and 1.0. Pairs of independent reviewers extracted data, appraised risk of bias, and assessed Grading of Recommendations Assessment, Development and Evaluation certainty of evidence. Five randomized controlled trials (RCTs) and 5 quasi RCTs included 2164 patients. Room air (Fio2 0.21) was associated with a statistically significant benefit in short-term mortality compared with 100% oxygen (Fio2 1.0) (7 RCTs n = 1469 risk ratio [RR] = 0.73 95% confidence interval [CI]: 0.57 to 0.94). No significant differences were observed in neurodevelopmental impairment (2 RCTs n = 360 RR = 1.41 95% CI: 0.77 to 2.60) or hypoxic-ischemic encephalopathy (5 RCTs n = 1315 RR = 0.89 95% CI: 0.68 to 1.18). The Grading of Recommendations Assessment, Development and Evaluation certainty of evidence was low for short-term mortality and hypoxic-ischemic encephalopathy and very low for neurodevelopmental impairment. Room air has a 27% relative reduction in short-term mortality compared with Fio2 1.0 for initiating neonatal resuscitation ≥35 weeks’ gestation.
Publisher: Elsevier BV
Date: 06-2021
Publisher: Frontiers Media SA
Date: 06-06-2019
Publisher: Wiley
Date: 29-04-2019
DOI: 10.1111/COBI.13329
Publisher: BMJ
Date: 15-11-2021
DOI: 10.1136/ARCHDISCHILD-2021-322230
Abstract: To assess associations between 5 min Apgar score and mortality and severe neurological injury (SNI) and to report test characteristics in preterm neonates. Retrospective cohort study of neonates 24 0 to 28 6 weeks’ gestation born between 2007 and 2016 and admitted to neonatal units in 11 high-income countries. 5 min Apgar score. In-hospital mortality and SNI defined as grade 3 or 4 periventricular/intraventricular haemorrhage or periventricular leukomalacia. Outcome rates were calculated for each Apgar score and compared after adjustment. The diagnostic characteristics and ORs for each value from 0 versus 1–10 to 0–9 versus 10, with 1-point increments were calculated. Among 92 412 included neonates, as 5 min Apgar score increased from 0 to 10, mortality decreased from 60% to 8%. However, no clear increasing or decreasing pattern was identified for SNI. There was an increase in sensitivity and decrease in specificity for both mortality and SNI associated with increasing scores. The Apgar score alone had an area under the curve of 0.64 for predicting mortality, which increased to 0.73 with the addition of gestational age. In neonates of 24–28 weeks’ gestation admitted to neonatal units, higher 5 min Apgar score was associated with lower mortality in a graded manner, while the association with SNI remained relatively constant at all scores. Among survivors, low Apgar scores did not predict SNI.
Publisher: American Academy of Pediatrics (AAP)
Date: 2019
Abstract: The International Liaison Committee on Resuscitation prioritized to review the initial fraction of inspired oxygen (Fio2) during the resuscitation of preterm newborns. This systematic review and meta-analysis provides the scientific summary of initial Fio2 in preterm newborns (& weeks’ gestation) who receive respiratory support at birth. Medline, Embase, Evidence-Based Medicine Reviews, and Cumulative Index to Nursing and Allied Health Literature were searched between January 1, 1980 and August 10, 2018. Studies were selected by pairs of independent reviewers in 2 stages with a Cohen’s κ of 0.8 and 1.0. Pairs of independent reviewers extracted data, appraised the risk of bias (RoB), and assessed Grading of Recommendations Assessment, Development and Evaluation certainty. Ten randomized controlled studies and 4 cohort studies included 5697 patients. There are no statistically significant benefits of or harms from starting with lower compared with higher Fio2 in short-term mortality (n = 968 risk ratio = 0.83 [95% confidence interval 0.50 to 1.37]), long-term mortality, neurodevelopmental impairment, or other key preterm morbidities. A sensitivity analysis in which 1 study with a high RoB was excluded failed to reveal a reduction in mortality with initial low Fio2 (n = 681 risk ratio = 0.63 [95% confidence interval 0.38 to 1.03]). The Grading of Recommendations Assessment, Development and Evaluation certainty of evidence was very low for all outcomes due to RoB, inconsistency, and imprecision. The ideal initial Fio2 for preterm newborns is still unknown, although the majority of newborns ≤32 weeks’ gestation will require oxygen supplementation.
Publisher: Public Library of Science (PLoS)
Date: 16-11-2018
Publisher: Springer Science and Business Media LLC
Date: 12-11-2019
DOI: 10.1038/S41598-019-52992-Y
Abstract: An understanding of the core demographic characteristics of the sub-populations of FRD is essential to effectively implement both rabies control interventions through mass vaccination of FRD, and dog population control programmes. This study compares the data obtained following photographic sight-resight surveys in rural (Shirsuphal village in west India) and urban (Municipal Corporation Panchkula in north India) locations . A total of 263 and 1408 FRD were seen at least once through 617 and 3465 sightings in the rural and urban sites, respectively. The rural location had a lower proportion of females (OR 0.5, 95% CI 0.4–0.7) and a higher proportion of poor and fair conditioned dogs (OR 1.8, 95% CI 1.3–2.3) compared to the urban setting. The rural site also had fewer active FRD (OR 0.6, 95% CI 0.5–0.7) and FRD were less likely to be sighted within 20 m of garbage points (OR 0.3, 95% CI 0.2–0.3) compared to the urban site. The demographic composition of the FRD population was found to vary within the urban location, with the odds of sighting a de-sexed dog being significantly higher in residential areas compared to other areas. The study underlines the importance of knowing the demographic composition of FRD for implementation of effective interventions against rabies. Fewer female dogs in the rural location indicate that spaying could be an effective tool for dog population management in this setting, while presence of dogs within 20 m of garbage points in urban settings highlights that an improved garbage management may reduce the carrying capacity of the urban locality resulting in smaller FRD population. It is concluded that quick and low cost surveys can generate useful demographic data for FRD in urban and rural settings which can be useful to understand the epidemiology of rabies and its control.
Publisher: American Academy of Pediatrics (AAP)
Date: 12-2017
Abstract: To compare survival rates and age at death among very preterm infants in 10 national and regional neonatal networks. A cohort study of very preterm infants, born between 24 and 29 weeks’ gestation and weighing & g, admitted to participating neonatal units between 2007 and 2013 in the International Network for Evaluating Outcomes of Neonates. Survival was compared by using standardized ratios (SRs) comparing survival in each network to the survival estimate of the whole population. Network populations differed with respect to rates of cesarean birth, exposure to antenatal steroids and birth in nontertiary hospitals. Network SRs for survival were highest in Japan (SR: 1.10 99% confidence interval: 1.08–1.13) and lowest in Spain (SR: 0.88 99% confidence interval: 0.85–0.90). The overall survival differed from 78% to 93% among networks, the difference being highest at 24 weeks’ gestation (range 35%–84%). Survival rates increased and differences between networks diminished with increasing gestational age (GA) (range 92%–98% at 29 weeks’ gestation) yet, relative differences in survival followed a similar pattern at all GAs. The median age at death varied from 4 days to 13 days across networks. The network ranking of survival rates for very preterm infants remained largely unchanged as GA increased however, survival rates showed marked variations at lower GAs. The median age at death also varied among networks. These findings warrant further assessment of the representativeness of the study populations, organization of perinatal services, national guidelines, philosophy of care at extreme GAs, and resources used for decision-making.
Publisher: Frontiers Media SA
Date: 23-05-2018
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 10-12-2019
DOI: 10.1161/CIR.0000000000000734
Abstract: The International Liaison Committee on Resuscitation has initiated a continuous review of new, peer-reviewed, published cardiopulmonary resuscitation science. This is the third annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. It addresses the most recent published resuscitation evidence reviewed by International Liaison Committee on Resuscitation Task Force science experts. This summary addresses the role of cardiac arrest centers and dispatcher-assisted cardiopulmonary resuscitation, the role of extracorporeal cardiopulmonary resuscitation in adults and children, vasopressors in adults, advanced airway interventions in adults and children, targeted temperature management in children after cardiac arrest, initial oxygen concentration during resuscitation of newborns, and interventions for presyncope by first aid providers. Members from 6 International Liaison Committee on Resuscitation task forces have assessed, discussed, and debated the certainty of the evidence on the basis of the Grading of Recommendations, Assessment, Development, and Evaluation criteria, and their statements include consensus treatment recommendations. Insights into the deliberations of the task forces are provided in the Justification and Evidence to Decision Framework Highlights sections. The task forces also listed priority knowledge gaps for further research.
Location: India
No related grants have been discovered for Tetsuya Isayama.