ORCID Profile
0000-0002-4270-4423
Current Organisations
Northeastern University
,
QIMR Berghofer Medical Research Institute
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Publisher: Elsevier BV
Date: 05-2020
Publisher: American Society for Microbiology
Date: 04-2017
DOI: 10.1128/CMR.00074-16
Abstract: BK polyomavirus (BKV) causes frequent infections during childhood and establishes persistent infections within renal tubular cells and the uroepithelium, with minimal clinical implications. However, reactivation of BKV in immunocompromised in iduals following renal or hematopoietic stem cell transplantation may cause serious complications, including BKV-associated nephropathy (BKVAN), ureteric stenosis, or hemorrhagic cystitis. Implementation of more potent immunosuppression and increased posttransplant surveillance has resulted in a higher incidence of BKVAN. Antiviral immunity plays a crucial role in controlling BKV replication, and our increasing knowledge about host-virus interactions has led to the development of improved diagnostic tools and clinical management strategies. Currently, there are no effective antiviral agents for BKV infection, and the mainstay of managing reactivation is reduction of immunosuppression. Development of immune-based therapies to combat BKV may provide new and exciting opportunities for the successful treatment of BKV-associated complications.
Publisher: Cold Spring Harbor Laboratory
Date: 13-10-2021
DOI: 10.1101/2021.10.13.464181
Abstract: Understanding the immune response to severe acute respiratory syndrome coronavirus (SARS-CoV-2) is critical to overcome the current coronavirus disease (COVID-19) pandemic. Efforts are being made to understand the potential cross-protective immunity of memory T cells, induced by prior encounters with seasonal coronaviruses, in providing protection against severe COVID-19. In this study we assessed T-cell responses directed against highly conserved regions of SARS-CoV-2. Epitope mapping revealed 16 CD8 + T-cell epitopes across the nucleocapsid (N), spike (S) and ORF3a proteins of SARS-CoV-2 and five CD8 + T-cell epitopes encoded within the highly conserved regions of the ORF1ab polyprotein of SARS-CoV-2. Comparative sequence analysis showed high conservation of SARS-CoV-2 ORF1ab T-cell epitopes in seasonal coronaviruses. Paradoxically, the immune responses directed against the conserved ORF1ab epitopes were infrequent and subdominant in both convalescent and unexposed participants. This subdominant immune response was consistent with a low abundance of ORF1ab encoded proteins in SARS-CoV-2 infected cells. Overall, these observations suggest that while cross-reactive CD8 + T cells likely exist in unexposed in iduals, they are not common and therefore are unlikely to play a significant role in providing broad pre-existing immunity in the community.
Publisher: Springer Science and Business Media LLC
Date: 08-11-2021
Publisher: Elsevier BV
Date: 2016
DOI: 10.1038/MTM.2016.58
Publisher: Hindawi Limited
Date: 06-07-2022
DOI: 10.1002/ER.8354
Publisher: Elsevier BV
Date: 07-2023
Publisher: Wiley
Date: 14-07-2020
DOI: 10.1111/TID.13399
Publisher: Elsevier BV
Date: 2022
Publisher: Wiley
Date: 2020
DOI: 10.1002/CTI2.1102
No related grants have been discovered for George Robin Ambalathingal.