ORCID Profile
0000-0002-7911-2456
Current Organisation
Universidade Federal de Minas Gerais
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Publisher: Public Library of Science (PLoS)
Date: 27-10-2014
Publisher: Elsevier BV
Date: 07-2012
Publisher: Springer Science and Business Media LLC
Date: 13-01-2016
Publisher: IEEE
Publisher: IEEE
Date: 10-2019
Publisher: Elsevier BV
Date: 10-2017
Publisher: Springer New York
Date: 03-11-2014
DOI: 10.1007/978-1-4939-2155-3_12
Abstract: We propose here a methodology to uncover modularities in the network of SNP-SNP interactions most associated with disease. We start by computing all possible Boolean binary SNP interactions across the whole genome. By constructing a weighted graph of the most relevant interactions and via a combinatorial optimization approach, we find the most highly interconnected SNPs. We show that the method can be easily extended to find SNP/environment interactions. Using a modestly sized GWAS dataset of age-related macular degeneration (AMD), we identify a group of only 19 SNPs, which include those in previously reported regions associated to AMD. We also uncover a larger set of loci pointing to a matrix of key processes and functions that are affected. The proposed integrative methodology extends and overlaps traditional statistical analysis in a natural way. Combinatorial optimization techniques allow us to find the kernel of the most central interactions, complementing current methods of GWAS analysis and also enhancing the search for gene-environment interaction.
Publisher: Elsevier BV
Date: 03-2014
Publisher: IEEE
Date: 07-2018
Publisher: IEEE
Date: 07-2006
Publisher: IEEE
Date: 10-2016
Publisher: IEEE
Date: 10-2018
Publisher: IEEE
Date: 2005
Publisher: IEEE
Date: 2005
Publisher: Springer Berlin Heidelberg
Date: 2004
Publisher: Wiley
Date: 11-02-2014
DOI: 10.1111/BJU.12497
Abstract: To study the influence of adjuvant androgen suppression and bisphosphonates on incident vertebral and non-spinal fracture rates and bone mineral density (BMD) in men with locally advanced prostate cancer. Between 2003 and 2007, 1071 men with locally advanced prostate cancer were randomly allocated, using a 2 × 2 trial design, to 6 months i.m. leuprorelin (androgen suppression [AS]) before radiotherapy alone ± 12 months additional leuprorelin ± 18 months zoledronic acid (ZdA), commencing at randomization. The main endpoint was incident thoraco-lumbar vertebral fractures, which were assessed radiographically at randomization and at 3 years, then reassessed by centralized review. Subsidiary endpoints included incident non-spinal fractures, which were documented throughout follow-up, and BMD, which was measured in 222 subjects at baseline, 2 years and 4 years. Incident vertebral fractures at 3 years were observed in 132 subjects. Their occurrence was not increased by 18 months' AS, nor reduced by ZdA. Incident non-spinal fractures occurred in 72 subjects and were significantly related to AS duration but not to ZdA. Osteopenia and osteoporosis prevalence rates at baseline were 23.4 and 1.4%, respectively, at the hip. Treatment for 6 and 18 months with AS caused significant reductions in hip BMD at 2 and 4 years (P < 0.01) and ZdA prevented these losses at both time points. In an AS-naïve population, 18 months of ZdA treatment prevented the sustained BMD losses caused by 18 months of AS treatment however, the study power was insufficient to show that AS duration or ZdA influenced vertebral fracture rates.
Publisher: Elsevier BV
Date: 10-2014
Publisher: Public Library of Science (PLoS)
Date: 22-04-2026
Publisher: IEEE
Date: 10-2019
No related grants have been discovered for Renato Vimieiro.