ORCID Profile
0000-0002-5290-2490
Current Organisations
Nanjing University of Technology
,
Nanjing Normal University
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Publisher: Elsevier BV
Date: 2015
Publisher: Elsevier BV
Date: 09-2019
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0CC04157B
Abstract: A mild synthetic protocol to access 2-ester pyrroles through Cu(OTf) 2 -catalysed carbene insertion/ester migration/cyclization of enaminones and α-diazo compounds is reported.
Publisher: American Chemical Society (ACS)
Date: 18-02-2020
Publisher: American Chemical Society (ACS)
Date: 27-09-2022
Abstract: Electrochemical synthesis of polysubstituted sulfonated pyrazoles from enaminones and sulfonyl hydrazides was established under metal-free, exogenous-oxidant-free, and mild conditions. By judicious choice of different electrochemical reaction conditions,
Publisher: American Chemical Society (ACS)
Date: 08-09-2023
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9QO01413F
Abstract: Herein, both homogeneous and heterogeneous strategies were developed to access highly functionalized 3 H -1,2,4-triazines using Cu-catalyzed [4 + 2] annulation.
Publisher: American Chemical Society (ACS)
Date: 15-03-2019
DOI: 10.1021/ACS.JMEDCHEM.8B01790
Abstract: A phenotypic screen of two different libraries of small molecules against the motility and development of the parasitic nematode Haemonchus contortus led to the identification of two 1-methyl-1 H-pyrazole-5-carboxamide derivatives. Medicinal chemistry optimization targeted modifications of the left-hand side, middle section, and right-hand side of the hybrid structure of these two hits to elucidate the structure-activity relationship (SAR). Initial SAR around these hits allowed for the iterative and directed assembly of a focused set of 30 analogues of their hybrid structure. Compounds 10, 17, 20, and 22 were identified as the most potent compounds, inhibiting the development of the fourth larval (L4) stage of H. contortus at sub-nanomolar potencies while displaying strong selectivity toward the parasite when tested in vitro against the human MCF10A cell line. In addition, compounds 9 and 27 showed promising activity against a panel of other parasitic nematodes, including hookworms and whipworms.
Publisher: American Chemical Society (ACS)
Date: 06-2023
Publisher: Wiley
Date: 13-02-2014
Abstract: The functionalization of internal olefins has been a challenging task in organic synthesis. Efficient CuII-catalyzed trifluoromethylation of internal olefins, that is, α-oxoketene dithioacetals, has been achieved by using Cu(OH)2 as a catalyst and TMSCF3 as a trifluoromethylating reagent. The push-pull effect from the polarized olefin substrates facilitates the internal olefinic C-H trifluoromethylation. Cyclic and acyclic dithioalkyl α-oxoketene acetals were used as the substrates and various substituents were tolerated. The internal olefinic C-H bond cleavage was not involved in the rate-determining step, and a mechanism that involves radicals is proposed based on a TEMPO-quenching experiment of the trifluoromethylation reaction. Further derivatization of the resultant CF3 olefins led to multifunctionalized tetrasubstituted CF3 olefins and trifluoromethylated N-heterocycles.
Publisher: Elsevier BV
Date: 03-2018
Publisher: Elsevier BV
Date: 12-2018
Publisher: American Chemical Society (ACS)
Date: 10-01-2023
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2OB01273A
Abstract: An electrochemical insertion reaction of diazo compounds into C–S and C–O bonds with electricity as the oxidant under metal- and ligand-free conditions is reported.
Publisher: Wiley
Date: 26-07-2023
Abstract: 3‐Azabicyclo[3.1.0]hexanes are an important class of nitrogen‐containing heterocycles that have been found to be key structural features in a wide range of biologically active natural products, drugs, and agrochemicals. As a cutting‐edge area, the synthesis of these derivatives has made spectacular progress in recent decades, with various transition‐metal‐catalyzed and transition‐metal‐free catalytic systems being developed. In this review, we provide an overview of recent advances in the efficient methods for the synthesis of 3‐azabicyclo[3.1.0]hexane derivatives since 2010, emphasizing the scope of substrates and synthesis’ applications, as well as the mechanisms of these reactions.
Publisher: Wiley
Date: 24-07-2023
Abstract: A copper‐catalyzed olefinic C( sp 2 )−H activation/carbene insertion/ester hydrolysis/cyclization sequence has been developed for the synthesis of substituted 2(5 H )‐furanones employing readily available enaminones and aryl diazo esters as substrates. This method features operationally simple and good functional group tolerance. The transformation could be scaled up to gram quantities and the obtained 2(5 H )‐furanone derivatives could be easily converted to a wide range of useful synthetic building blocks, indicative of the applicability of the synthetic strategy. Isotope labeling experiments demonstrated the ester group of diazo esters was hydrolyzed during the reaction.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9GC03428E
Abstract: More economically and greener surface modified sewage sludge for carbene insertion of diazo compounds into O–H bond of phenols with good yields and high functional group tolerance.
Publisher: Springer Science and Business Media LLC
Date: 28-06-2018
DOI: 10.1007/S11356-018-2607-9
Abstract: Sludge-derived carbons (SCs) were modified by different acids and used as electrocatalyst for electrochemical oxidation degradation of acetophenone. The results showed that SC treated with phosphoric acid (H
Publisher: American Chemical Society (ACS)
Date: 20-07-2021
Publisher: American Chemical Society (ACS)
Date: 22-12-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3QO00458A
Abstract: Efficient synthetic protocols for borylation of haloarenes and arylation of heteroarenes using nonmetal-doped CDots as metal-free photocatalysts under visible-light irradiation at room temperature are reported.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7OB01234A
Abstract: Efficient copper-promoted direct C–H alkoxylation of internal olefins, α-oxo ketene dithioacetals, was achieved with alcohols as the alkoxylating reagents.
Publisher: American Chemical Society (ACS)
Date: 10-01-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4QO00122B
Abstract: Construction of the benzene ring was efficiently realized through a palladium( ii )-catalyzed, copper( ii )-mediated domino dehydrochlorination/alkenylation/cycloaddition–oxidation sequence.
Publisher: American Chemical Society (ACS)
Date: 13-07-2012
DOI: 10.1021/OL301517Y
Abstract: Cu(OAc)(2)-mediated dehydrogenative cross-coupling between two heteroarenes has been realized in the absence of any other additive. A mechanism involving a formal Cu(II) to Cu(0) route by convergent disproportionation of the copper mediator is proposed and has been evidenced by copper mirror formation during the reaction. This synthetic protocol provides a concise and "green" access to unsymmetrical biheteroarenes bearing structural motifs of substantial utility in organic synthesis.
Publisher: American Chemical Society (ACS)
Date: 02-01-2023
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7RA06119F
Abstract: NLC co-delivering PTX and ICG for synergetic cancer therapy.
Publisher: Springer Science and Business Media LLC
Date: 18-11-2023
DOI: 10.1038/S41375-022-01755-2
Abstract: Chemotherapy-resistant acute myeloid leukemia (AML), frequently driven by clonal evolution, has a dismal prognosis. A genome-wide CRISPR knockout screen investigating resistance to doxorubicin and cytarabine (Dox/AraC) in human AML cell lines identified gene knockouts involving AraC metabolism and genes that regulate cell cycle arrest (cyclin dependent kinase inhibitor 2A (CDKN2A), checkpoint kinase 2 (CHEK2) and TP53) as contributing to resistance. In human AML cohorts, reduced expression of CDKN2A conferred inferior overall survival and CDKN2A downregulation occurred at relapse in paired diagnosis-relapse s les, validating its clinical relevance. Therapeutically targeting the G
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4CC05837B
Abstract: CuCl 2 and CuBr 2 -mediated intramolecular oxidative C–H/N–H cross-coupling/halogenation of β-thioalkyl-α-alkenoyl ketene N , S -acetals provides a new concise synthetic route to pyrrolones.
Publisher: American Chemical Society (ACS)
Date: 20-12-2018
DOI: 10.1021/ACS.JMEDCHEM.8B01789
Abstract: Recently, we have discovered that the registered pesticide, tolfenpyrad, unexpectedly and potently inhibits the development of the L4 larval stage of the parasitic nematode Haemonchus contortus with an IC
Publisher: Wiley
Date: 07-12-2015
Abstract: Transition-metal-catalyzed C-alkylation of ketones and secondary alcohols, with alcohols, avoids use of organometallic or environmentally unfriendly alkylating agents by means of borrowing hydrogen (BH) or hydrogen autotransfer (HA) activation of the alcohol substrates. Water is formed as the only by-product, thus making the BH process atom-economical and environmentally benign. Diverse homogeneous and heterogeneous transition-metal catalysts, ketones, and alcohols can be used for this transformation, thus rendering the BH process promising for replacing those procedures that use traditional alkylating agents. This Minireview summarizes the advances during the last five years in transition-metal-catalyzed BH α-alkylation of ketones, and β-alkylation of secondary alcohols with alcohols. A discussion on the application of the BH strategy for C-C bond formation is included.
Publisher: American Chemical Society (ACS)
Date: 16-10-2014
DOI: 10.1021/JO5014542
Abstract: CuCl2-mediated intramolecular C-H/C-H cross-dehydrogenative coupling (CDC) of thioalkyl-substituted α-acetyl or α-aroyl ketene N,S-acetals afforded 2-thioalkyl indoles. Tunable C-S bond transformations of the resultant indoles led to highly functionalized N-heterocyclic compounds. A β-thioalkyl is necessary to activate the N,S-acetal substrate and enable the CDC reaction to occur, and the relevant mechanism studies revealed that the CDC reaction follows a radical pathway.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0GC00317D
Abstract: A green, mild and efficient synthesis of diarylmethines using sewage sludge-derived carbonaceous materials (SW) by perchloric acid catalyzed coupling reactions between diazo compounds and arylboronic acids was developed.
Publisher: American Chemical Society (ACS)
Date: 17-04-2012
DOI: 10.1021/JO202624S
Abstract: A Lewis acid (Ag(I), Ni(II), or Fe(II)) catalyzed, Cu(II)-mediated thiolation reaction between heteroarenes and thiols was achieved with good yield under base-free conditions. DMSO could serve as an effective methylthiolation reagent for the synthesis of heterocyclic methyl thioethers.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0QO01401J
Abstract: The economical and accessible CF 3 SO 3 H successfully catalyzed homogeneous O–H and S–H bond insertion reactions between hydroxyl compounds, thiols and diazo compounds under metal- and ligand-free conditions.
Publisher: American Chemical Society (ACS)
Date: 14-06-2017
DOI: 10.1021/ACS.ORGLETT.7B01668
Abstract: Efficient copper-catalyzed formal carbene migratory insertion into the olefinic C═C bonds of internal olefins, that is, α-oxo ketene N,S-acetals, has been achieved by means of N-tosylhydrazones of ketones as the carbene precursors. Iminofuran derivatives were obtained and further transformed to the corresponding 2(3H)-furanones and 4-oxobutanoates (γ-ketoesters), respectively, under mild conditions. In a similar fashion, α-thioxo ketene N,S-acetals reacted with N-tosylhydrazones of ketones to afford iminothiophenes. It is suggested that formal carbene migratory insertion into the olefinic C═C bond is involved in the overall catalytic cycle, demonstrating a new type of carbene insertion reaction for five-membered heterocycle construction.
Publisher: American Chemical Society (ACS)
Date: 17-04-2018
Abstract: Amide bond formation is one of the most important transformations in organic synthesis, drug development, and materials science. Efficient construction of amides has been among the most challenging tasks for organic chemists. Herein, we report a concise methodology for amide bond (-CONH-) formation assisted by vicinal group migration in alkylthio-functionalized enaminones (α-oxo ketene N, S-acetals) under mild conditions. Simple treatment of such enaminones with PhI(OAc)
Publisher: Wiley
Date: 18-03-2020
Publisher: Elsevier BV
Date: 03-2019
DOI: 10.1016/J.SCITOTENV.2018.11.156
Abstract: In this study, heterogeneous Fenton-like degradation of ofloxacin (OFX) was investigated by sludge derived carbon (SC). The effects of SC catalyst, temperature and pH on the efficiency of ofloxacin degradation were investigated. SC treated with sulfuric acid (SC-H
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9CC08389H
Abstract: The intermolecular C–C, C–O, C–S and C–N bonds construction between diazo compounds and acyclic, cyclic 1,3-dicarbonyl compounds, thiophenol, alkynes were developed by using a TFMSA@SBA-15, providing a metal-free and eco-friendly platform.
Publisher: Elsevier BV
Date: 05-2015
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0OB01958E
Abstract: The switch in selectivity for the synthesis of 1,4-dihydropyridazines and pyridazines is attributed to the judicious choice of different reaction temperatures.
No related grants have been discovered for Fei Huang.