ORCID Profile
0000-0003-1343-8784
Current Organisation
Vanderbilt University Medical Center
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Publisher: Elsevier BV
Date: 08-2020
Publisher: Elsevier BV
Date: 04-2011
Publisher: S. Karger AG
Date: 2013
DOI: 10.1159/000349962
Publisher: Springer Science and Business Media LLC
Date: 21-12-2018
Publisher: Springer Science and Business Media LLC
Date: 28-05-2021
DOI: 10.1186/S12882-021-02400-3
Abstract: Acute kidney injury (AKI) and obesity are independent risk factors for chronic kidney disease (CKD). This study aimed to determine if obesity modifies risk for CKD outcomes after AKI. This prospective multisite cohort study followed adult survivors after hospitalization, with or without AKI. The primary outcome was a combined CKD event of incident CKD, progression of CKD and kidney failure, examined using time-to-event Cox proportional hazards models, adjusted for diabetes status, age, pre-existing CKD, cardiovascular disease status and intensive care unit admission, and stratified by study center. Body mass index (BMI) was added as an interaction term to examine effect modification by body size. The cohort included 769 participants with AKI and 769 matched controls. After median follow-up of 4.3 years, among AKI survivors, the rate of the combined CKD outcome was 84.7 per1000-person-years with BMI ≥30 kg/m 2 , 56.4 per 1000-person-years with BMI 25–29.9 kg/m 2 , and 72.6 per 1000-person-years with BMI 20–24.9 kg/m 2 . AKI was associated with a higher risk of combined CKD outcomes adjusted-HR 2.43 (95%CI 1.87–3.16), with no evidence that this was modified by BMI ( p for interaction = 0.3). After adjustment for competing risk of death, AKI remained associated with a higher risk of the combined CKD outcome (subdistribution-HR 2.27, 95%CI 1.76–2.92) and similarly, there was no detectable effect of BMI modifying this risk. In this post-hospitalization cohort, we found no evidence for obesity modifying the association between AKI and development or progression of CKD.
Publisher: Springer Science and Business Media LLC
Date: 27-02-2017
Abstract: Consensus definitions have been reached for both acute kidney injury (AKI) and chronic kidney disease (CKD) and these definitions are now routinely used in research and clinical practice. The KDIGO guideline defines AKI as an abrupt decrease in kidney function occurring over 7 days or less, whereas CKD is defined by the persistence of kidney disease for a period of >90 days. AKI and CKD are increasingly recognized as related entities and in some instances probably represent a continuum of the disease process. For patients in whom pathophysiologic processes are ongoing, the term acute kidney disease (AKD) has been proposed to define the course of disease after AKI however, definitions of AKD and strategies for the management of patients with AKD are not currently available. In this consensus statement, the Acute Disease Quality Initiative (ADQI) proposes definitions, staging criteria for AKD, and strategies for the management of affected patients. We also make recommendations for areas of future research, which aim to improve understanding of the underlying processes and improve outcomes for patients with AKD.
Location: United States of America
Location: United States of America
No related grants have been discovered for Edward Siew.