ORCID Profile
0000-0003-3349-9090
Current Organisations
Christian Medical College & Hospital
,
Albert Einstein College of Medicine
,
University of North Carolina at Chapel Hill
,
CBM College
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Publisher: Elsevier BV
Date: 09-2001
DOI: 10.1046/J.1523-1755.2001.0600031148.X
Abstract: Post-transplant tuberculosis (post-TxTB) occurs in 12 to 20% of patients in India and results in the death of 20 to 25% of those patients. Prospective studies on post-TxTB are few. Renal allograft recipients were studied prospectively for 3.1 (0 to 13.9) median (range) years for incidence, manifestations, risk factors, and prognosis for post-TxTB. Kaplan-Meier analysis was used to study the survival rates. The extended Cox proportional model for time-dependent covariates was used to measure the risk factors when the hazard was nonuniform. Of the 1414 patients considered for inclusion, multiple-transplant subjects (N = 37) and patients who developed pre-transplant TB (pre-TxTB N = 126) were excluded from the study. The prevalence of post-TxTB was 13.3% (N = 166). The risk of post-TxTB when on cyclosporine (CsA) therapy was 2.5 (P = 0.0311) and 1.9 (P = 0.0430) times at < or =6 and < or =12 months, respectively, compared with patients on prednisolone plus azathioprine (PRED + AZA). The risk of post-TxTB in the presence of diabetes mellitus, chronic liver disease, and other co-existing infections [including deep mycoses, cytomegalovirus (CMV), Pneumocystis carinii pneumonia (PCP), nocardia] was 2.2 (P = 0.0011), 1.7 (P = 0.0010) and 2.4 (P 2 years (P = 0.0036), chronic liver disease> 6 years (P = 0.0457), PTDM> 5 years (P = 0.0729), diabetes mellitus (P = 0.0091), human lymphocyte antigen match < or =1 antigen (P = 0.0134), two to three antigens (P = 0.0448), and the presence of other co-existing infections (P 2 years) along with hyperglycemia, liver disease, and other co-existing infections are important risk factors for death.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 15-05-2003
Publisher: Elsevier BV
Date: 02-2003
Publisher: Elsevier BV
Date: 12-2002
Publisher: Wiley
Date: 07-2002
DOI: 10.1034/J.1399-0012.2002.01145.X
Abstract: The epidemiology of nocardiosis in the tropics among renal transplant recipients has not been reported. An evaluation of nocardiosis for 30 yr in one of the large transplant centres in South Asian region. Of the 1968 patients who received primary renal allografts at Christian Medical College & Hospital, 27 patients developed nocardiosis over 30 yr. Early nocardiosis ( 2 yr). Seventeen patients (63%) had two or more associated post-transplant infections, of whom 10 had tuberculosis. Mortality in these patients was associated with chronic liver disease. Nocardiosis manifests earlier (<2 yr) in CsA treated patients who have chronic liver disease. Among renal transplant recipients of the tropics nocardiosis is a marker of a high susceptibility to tuberculosis and other infections, the association with tuberculosis is stronger in those developing early nocardiosis (<2 yr). Chronic liver disease is a risk factor for death in patients with nocardiosis especially when associated with tuberculosis. This report constitutes the largest single centre experience among renal transplant recipients.
Publisher: Termedia Sp. z.o.o.
Date: 2016
Publisher: Informa UK Limited
Date: 12-2014
DOI: 10.2147/COPD.S53590
Location: United States of America
Location: United States of America
No related grants have been discovered for Shankar Viswanathan.