ORCID Profile
0000-0001-7416-9448
Current Organisations
St Vincent's Clinic
,
St Vincent's Hospital Sydney
,
War Memorial Hospital Waverley
,
St Vincent's Private Hospital Sydney
,
The University of Notre Dame Australia - Sydney Campus Broadway
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Publications
Acoustic Signal Classification by Support Vector Machine for Pipe Crack Early Warning in Smart Water Networks
Publisher: American Society of Civil Engineers (ASCE)
Date: 07-2022
Bridge to Recovery with Early Mobilisation: The Impella Device via Axillary Artery in Lupus-Associated Acute Cardiomyopathy
Publisher: Elsevier BV
Date: 2018
Eosinophilic annular erythema: a subset of Wells' syndrome or a distinct entity?
Publisher: Wiley
Date: 08-07-2008
DOI: 10.1111/J.1440-0960.2008.00456.X
Abstract: A 52-year-old woman with a 6-year history of a persistent non-pruritic cutaneous annular eruption, forming polycyclic and arcuate plaques that commenced as erythematous papules and nodules, is presented. Lethargy and arthralgia were associated symptoms. We have followed this patient for the last 3 years, and during this period she has continued to have a florid annular eruption of unknown cause. Laboratory tests, including an eosinophil count, examination of stool s les for parasites, and a computed tomography scan of the chest, abdomen and pelvis, failed to detect any abnormalities. Skin biopsies demonstrated a superficial to deep cellular infiltrate consisting of numerous eosinophils, with lymphocytes and isolated neutrophils. Eosinophilic dust, flame figures and granulomatous inflammation were not seen. In addition, strands of mucin were present through the dermis, and prominent basal vacuolar change was evident at the dermoepidermal junction these features may represent new findings that help define a distinct form of eosinophilic annular erythema.
Nonsteroidal anti-inflammatory drugs. Differential use in older patients.
Publisher: Springer Science and Business Media LLC
Date: 02-1994
DOI: 10.2165/00002512-199404020-00003
Abstract: The nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used medications, particularly in elderly patients, for both rheumatic and nonrheumatic conditions. Elderly patients are more prone to the adverse effects of these agents. Adverse effects are seen in almost every organ system, but the gastrointestinal tract is most frequently affected. Elderly patients are more at risk of adverse effects from a wide range of pharmacokinetic and pharmacodynamic interactions compared with younger patients. By cautious prescribing, including giving due consideration to these factors, the risks associated with NSAIDs in elderly patients can be minimised.
Leak-Before-Break Main Failure Prevention for Water Distribution Pipes Using Acoustic Smart Water Technologies: Case Study in Adelaide
Publisher: American Society of Civil Engineers (ASCE)
Date: 10-2020
Potential role of coenzyme Q 10 in facilitating recovery from statin‐induced rhabdomyolysis
Publisher: Wiley
Date: 04-2015
DOI: 10.1111/IMJ.12712
Abstract: Rhabdomyolysis is a rare, but serious complication of statin therapy, and represents the most severe end of the spectrum of statin-induced myotoxicity. We report a case where coenzyme Q10 facilitated recovery from statin-induced rhabdomyolysis and acute renal failure, which had initially persisted despite statin cessation and haemodialysis. This observation is biologically plausible due to the recognised importance of coenzyme Q10 in mitochondrial bioenergetics within myocytes, and the fact that statins inhibit farnesyl pyrophosphate production, a biochemical step crucial for coenzyme Q10 synthesis. Coenzyme Q10 is generally well tolerated, and may potentially benefit patients with statin-induced rhabdomyolysis.
Enhancing Pipe-Break Early Warning in Smart Water Networks: Distinguishing Leaks from Water Uses
Publisher: American Society of Civil Engineers (ASCE)
Date: 07-2023
Carboxyfluorescein diacetate succinimidyl ester and the virgin lymphocyte: A marriage made in heaven
Publisher: Wiley
Date: 12-1999
DOI: 10.1046/J.1440-1711.1999.00871.X
Abstract: Carboxyfluorescein diacetate succinimidyl ester (CFSE) labelling of naïve lymphocyte populations provides unique insights into the immune response. The clonal nature of immune responses, necessitating clonal expansion to achieve a sufficiently large number of Ag-reactive effector cells, combined with the dependence of lymphocyte differentiation on cell ision, underlie the usefulness of CFSE in understanding the factors that regulate responses both in vitro and in vivo. We have combined CFSE labelling with Ag receptor transgenic models, using seven channel flow cytometry to track the correlation between cell ision and a number of other parameters, such as surface expression of activation markers, cytokine receptors and homing receptors, cytokine production, cytotoxic activity and indicators of apoptosis. Our data have allowed us to classify and understand immune responses in novel ways, suggesting many further avenues of enquiry and indicating previously unrecognized relationships between cell ision and eventual cell fate.
Pipe crack early warning for burst prevention by permanent acoustic noise level monitoring in smart water networks
Publisher: Informa UK Limited
Date: 20-10-2020
The Avidity Spectrum of T Cell Receptor Interactions Accounts for T Cell Anergy in a Double Transgenic Model
Publisher: Rockefeller University Press
Date: 18-01-1999
Abstract: The mechanism of self-tolerance in the CD4+ T cell compartment was examined in a double transgenic (Tg) model in which T cell receptor (TCR)-α/β Tg mice with specificity for the COOH-terminal peptide of moth cytochrome c in association with I-Ek were crossed with antigen Tg mice. Partial deletion of cytochrome-reactive T cells in the thymus allowed some self-specific CD4+ T cells to be selected into the peripheral T cell pool. Upon restimulation with peptide in vitro, these cells upregulated interleukin (IL)-2 receptor but showed substantially lower cytokine production and proliferation than cells from TCR Tg controls. Proliferation and cytokine production were restored to control levels by addition of saturating concentrations of IL-2, consistent with the original in vitro definition of T cell anergy. However, the response of double Tg cells to superantigen stimulation in the absence of exogenous IL-2 was indistinguishable from that of TCR Tg controls, indicating that these self-reactive cells were not intrinsically hyporesponsive. Measurement of surface expression of Tg-encoded TCR α and β chains revealed that cells from double Tg mice expressed the same amount of TCR-β as cells from TCR Tg controls, but only 50% of TCR-α, implying expression of more than one α chain. Naive CD4+ T cells expressing both Tg-encoded and endogenous α chains also manifested an anergic phenotype upon primary stimulation with cytochrome c in vitro, suggesting that low avidity for antigen can produce an anergic phenotype in naive cells. The carboxyfluorescein diacetate succinimidyl ester cell ision profiles in response to titered peptide ± IL-2 indicated that expression of IL-2 receptor correlated with peptide concentration but not TCR level, whereas IL-2 production was profoundly affected by the twofold decrease in specific TCR expression. Addition of exogenous IL-2 recruited double Tg cells into ision, resulting in a pattern of cell ision indistinguishable from that of controls. Thus, in this experimental model, cells expressing more than one α chain escaped negative selection to a soluble self-protein in the thymus and had an anergic phenotype indistinguishable from that of low avidity naive cells. The data are consistent with the notion that avidity-mediated selection for self-reactivity in the thymus may lead to the appearance of anergy within the peripheral, self-reactive T cell repertoire, without invoking the induction of hyporesponsiveness to TCR-mediated signals.
Disease-modifying antirheumatic drugs, including methotrexate, sulfasalazine, gold, antimalarials, and penicillamine.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 05-1994
Voriconazole‐Associated Periostitis: New Insights into Pathophysiology and Management
Publisher: Wiley
Date: 06-10-2021
DOI: 10.1002/JBM4.10557
Abstract: Voriconazole‐associated periostitis (VAP) is an underrecognized and unpredictable side effect of long‐term voriconazole therapy. We report two cases of VAP occurring in the post‐transplant setting: a 68‐year‐old lung transplant recipient who required ongoing voriconazole therapy, in whom urinary alkalinization was used to promote fluoride excretion and minimize voriconazole‐related skeletal toxicity, and a 68‐year‐old stem‐cell transplant recipient with a high voriconazole dose requirement, identified on pharmacogenomic testing to be a CYP2C19 ultrarapid metabolizer, the dominant enzyme in voriconazole metabolism. This is the first reported case of pharmacogenomic profiling in VAP and may explain the variability in in idual susceptibility to this uncommon adverse effect. Our findings provide new insights into both the management and underlying pathophysiology of VAP. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Related Organisations
The University Of Notre Dame Australia - Sydney Campus Broadway
Location: Australia
Related Funding Activities
No related grants have been discovered for Laila Girgis.