ORCID Profile
0000-0002-6614-9401
Current Organisations
The Institute of Cancer Research
,
Secretariat of the Pacific Community
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Publisher: Springer Science and Business Media LLC
Date: 10-03-2013
DOI: 10.1038/NCLIMATE1838
Publisher: Elsevier BV
Date: 06-2017
Publisher: Elsevier BV
Date: 02-2018
Publisher: S. Karger AG
Date: 2019
DOI: 10.1159/000501211
Abstract: b i Introduction: /i /b The cancer research community increasingly question the rigidity of eligibility criteria in clinical trials. Common reasons for “screen failure” (RFSF) are well documented however, their effect on subsequent standard therapy (SST) and outcomes is unclear. b i Methods: /i /b This retrospective study evaluated patients aged ≥18 years with solid malignancy who were listed as ineligible on a screening log between February 2011 and March 2018. Patients screen-failed for biomarker results or incorrect cancer stage rior treatment profile were excluded. Data were collected from electronic hospital records, including demographics, cancer history, RFSF, subsequent therapy, and outcomes. b i Results: /i /b Overall, 217 patients were eligible. The most common histologies were lung (28%), melanoma, colon, and pancreatic (all 11%) 90% were metastatic. The most common RFSF were rapid disease progression (PD 16%), performance status (PS) ≥2 (12%), and abnormal liver function tests (aLFT 12%). After screen failure, 129/217 (59%) had SST 9 were dose-reduced. Treatment-naïve or phase III trial-ineligible patients were more likely to receive SST than those pre-treated or phase I trial-ineligible (72/104 vs. 52/113, i /i = 0.0006 71/109 vs. 15/42, i /i = 0.00013), respectively. RFSF stabilised/improved in 104/217 (48%) the main RFSF was co-morbidity (19/104). The most common RFSF to deteriorate were rapid PD (27/72), PS ≥2 (20/72), and aLFT with liver metastases (LM 13/72). b i Conclusions: /i /b RFSF related to organ function rarely deteriorate unless directly involved with underlying malignancy. Most RFSF do not prevent patients from having SST, nor increase dose reductions, especially in treatment-naïve hase III trial-ineligible patients. Those with RFSF of poor PS, rapid PD, and aLFT from LM are less suitable for SST. Careful broadening of trial eligibility is warranted.
Publisher: Springer Science and Business Media LLC
Date: 16-06-2023
Publisher: Oxford University Press (OUP)
Date: 23-12-2014
Abstract: In the pelagic foodweb, micronekton at the mid-trophic level (MTL) are one of the lesser known components of the ocean ecosystem despite being a major driver of the spatial dynamics of their predators, of which many are exploited species (e.g. tunas). The Spatial Ecosystem and Population Dynamics Model is one modelling approach that includes a representation of the spatial dynamics of several epi- and mesopelagic MTL functional groups. The dynamics of these groups are driven by physical (temperature and currents) and biogeochemical (primary production, euphotic depth) variables. A key issue to address is the parameterization of the energy transfer from the primary production to these functional groups. We present a method using in situ acoustic data to estimate the parameters with a maximum likelihood estimation approach. A series of twin experiments conducted to test the behaviour of the model suggested that in the ideal case, that is, with an environmental forcing perfectly simulated and biomass estimates directly correlated with the acoustic signal, a minimum of 200 observations over several time steps at the resolution of the model is needed to estimate the parameter values with a minimum error. A transect of acoustic backscatter at 38 kHz collected during scientific cruises north of Hawaii allowed a first illustration of the approach with actual data. A discussion followed regarding the various sources of uncertainties associated with the use of acoustic data in micronekton biomass.
Publisher: Springer Science and Business Media LLC
Date: 29-07-2021
DOI: 10.1038/S41893-021-00745-Z
Abstract: Climate-driven redistribution of tuna threatens to disrupt the economies of Pacific Small Island Developing States (SIDS) and sustainable management of the world’s largest tuna fishery. Here we show that by 2050, under a high greenhouse gas emissions scenario (RCP 8.5), the total biomass of three tuna species in the waters of ten Pacific SIDS could decline by an average of 13% (range = −5% to −20%) due to a greater proportion of fish occurring in the high seas. The potential implications for Pacific Island economies in 2050 include an average decline in purse-seine catch of 20% (range = −10% to −30%), an average annual loss in regional tuna-fishing access fees of US$90 million (range = −US$40 million to –US$140 million) and reductions in government revenue of up to 13% (range = −8% to −17%) for in idual Pacific SIDS. Redistribution of tuna under a lower-emissions scenario (RCP 4.5) is projected to reduce the purse-seine catch from the waters of Pacific SIDS by an average of only 3% (range = −12% to +9%), indicating that even greater reductions in greenhouse gas emissions, in line with the Paris Agreement, would provide a pathway to sustainability for tuna-dependent Pacific Island economies. An additional pathway involves Pacific SIDS negotiating within the regional fisheries management organization to maintain the present-day benefits they receive from tuna, regardless of the effects of climate change on the distribution of the fish.
Publisher: Elsevier BV
Date: 02-2018
Publisher: The Oceanography Society
Date: 09-2009
Location: United States of America
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: Australia
Location: France
No related grants have been discovered for Inna Senina.