ORCID Profile
0000-0002-7504-6906
Current Organisations
Istituto Superiore di Sanità
,
CSIRO
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Publisher: Springer International Publishing
Date: 2021
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5EW00048C
Abstract: Australia responded to drought with water reform and the use of alternative water sources to ensure security of water supply, but at a cost.
Publisher: Oxford University Press (OUP)
Date: 13-09-2004
DOI: 10.1093/BRAIN/AWH249
Publisher: Springer Science and Business Media LLC
Date: 30-07-2018
DOI: 10.1007/S12035-018-1251-1
Abstract: Cerebrospinal fluid (CSF) total prion protein (t-PrP) is decreased in sporadic Creutzfeldt-Jakob disease (sCJD). However, data on the comparative signatures of t-PrP across the spectrum of prion diseases, longitudinal changes during disease progression, and levels in pre-clinical cases are scarce. T-PrP was quantified in neurological diseases (ND, n = 147) and in prion diseases from different aetiologies including sporadic (sCJD, n = 193), iatrogenic (iCJD, n = 12) and genetic (n = 209) forms. T-PrP was also measured in serial lumbar punctures obtained from sCJD cases at different symptomatic disease stages, and in asymptomatic prion protein gene (PRNP) mutation carriers. Compared to ND, t-PrP concentrations were significantly decreased in sCJD, iCJD and in genetic prion diseases associated with the three most common mutations E200K, V210I (associated with genetic CJD) and D178N-129M (associated with fatal familial insomnia). In contrast, t-PrP concentrations in P102L mutants (associated with the Gerstmann-Sträussler-Scheinker syndrome) remained unaltered. In serial lumbar punctures obtained at different disease stages of sCJD patients, t-PrP concentrations inversely correlated with disease progression. Decreased mean t-PrP values were detected in asymptomatic D178-129M mutant carriers, but not in E200K and P102L carriers. The presence of low CSF t-PrP is common to all types of prion diseases regardless of their aetiology albeit with mutation-specific exceptions in a minority of genetic cases. In some genetic prion disease, decreased levels are already detected at pre-clinical stages and diminish in parallel with disease progression. Our data indicate that CSF t-PrP concentrations may have a role as a pre-clinical or early symptomatic diagnostic biomarker in prion diseases as well as in the evaluation of therapeutic interventions.
Publisher: Elsevier BV
Date: 02-2006
Publisher: MDPI AG
Date: 12-02-2020
DOI: 10.3390/BIOM10020290
Abstract: Human prion diseases are classified into sporadic, genetic, and acquired forms. Within this last group, iatrogenic Creutzfeldt–Jakob disease (iCJD) is caused by human-to-human transmission through surgical and medical procedures. After reaching an incidence peak in the 1990s, it is believed that the iCJD historical period is probably coming to an end, thanks to lessons learnt from past infection sources that promoted new prion prevention and decontamination protocols. At this point, we sought to characterise the biomarker profile of iCJD and compare it to that of sporadic CJD (sCJD) for determining the value of available diagnostic tools in promptly recognising iCJD cases. To that end, we collected 23 iCJD s les from seven national CJD surveillance centres and analysed the electroencephalogram and neuroimaging data together with a panel of seven CSF biomarkers: 14-3-3, total tau, phosphorylated/total tau ratio, alpha-synuclein, neurofilament light, YKL-40, and real-time quaking induced conversion of prion protein. Using the cut-off values established for sCJD, we found the sensitivities of these biomarkers for iCJD to be similar to those described for sCJD. Given the limited relevant information on this issue to date, the present study validates the use of current sCJD biomarkers for the diagnosis of future iCJD cases.
Publisher: Elsevier BV
Date: 2020
Publisher: Springer Science and Business Media LLC
Date: 30-04-2017
Publisher: CSIRO
Date: 2012
Publisher: Elsevier BV
Date: 02-2022
Publisher: American Association for the Advancement of Science (AAAS)
Date: 02-08-1996
Publisher: CSIRO Publishing
Date: 2005
DOI: 10.1071/AR05072
Abstract: Policy issues have impacted on cropping since the earliest days of European colonial settlement. Following emigration to Australia, secure land titles were required, with the Torrens title system being progressively introduced from 1858. This provided the basis for landholders to be able to borrow to develop land. Closer settlement policies were adopted, underpinned by the development of transport infrastructure. The demand for education resulted in Agricultural Colleges in the colonies from the 1880s, with Departments of Agriculture soon afterwards. Federation of the colonies into the Commonwealth of Australia and the creation of the states resulted in a separation of powers, with the Commonwealth assuming responsibility for external powers including overseas marketing, import quarantine, health and quality standards of exports and credit and financial powers. Natural resource management matters and education were among those remaining with the states. Regular intergovernmental meetings were held to discuss research from 1927 and a broader range of agricultural issues from 1935. The Great Depression in the 1930s, poor commodity prices and serious land degradation led to government support for debt reconstruction and the introduction of soil conservation services. Realising the need for innovation to successfully compete on world markets, farmers, led by cereal growers, petitioned for the establishment of statutory research programs with joint grower/government funding from the 1950s. These have been remarkably successful, with the uptake of new technologies contributing to an average multifactor productivity growth of Australian grain farms by 3.3% per year between 1977–78 and 2001–02. With community and policy recognition of the need to conserve natural resources, the Commonwealth Government is playing an increasing role in this area. Farmers are required to meet standards for the use of agricultural chemicals and for occupational safety, welfare and environmental protection. The states have taken a conservative stand against the growing of genetically modified food crops in the name of protecting overseas markets. New water management regimes are coming into place with the separation of water titles from land. Market-based instruments are being introduced to encourage more sustainable production systems and saleable ecosystem services. Research and innovation along with complementary policy initiatives will continue to underpin farmers’ adaptive management skills to ensure dryland crop producers have sustainable production systems while remaining competitive in world markets.
Publisher: American Association for the Advancement of Science (AAAS)
Date: 20-01-1970
DOI: 10.1126/SCITRANSLMED.AAD5169
Abstract: Large genomic reference data sets reveal a spectrum of pathogenicity in the prion protein gene and provide genetic validation for a therapeutic strategy in prion disease.
Publisher: Australian Water Association
Date: 2017
Publisher: Elsevier BV
Date: 06-2018
Publisher: Elsevier BV
Date: 02-2005
No related grants have been discovered for Anna ladogana.