ORCID Profile
0000-0002-0293-964X
Current Organisations
Tongji University
,
World Scientific Publishing
,
Wiley VCH Verlag GmbH und Co KG
,
Versita
,
Wiley-VCH
,
Taylor & Francis Group
,
the Hong Kong Chemical Society
,
the Hong Kong Chapter of the American Chemical Society
,
the Hong Kong Materials Research Society
,
the Hong Kong Institute of Science
,
the Asian and Oceania Photochemistry Association
,
Old City Publishing
,
Northeast Normal University
,
Optoelectronics Science & Technology Frontiers Series, Science Press
,
Journal of Molecular Engineering & Systems Biology, Herbert Publications Limited
,
Nature Publishing Group
,
Materials Chemistry Frontiers, Royal Society of Chemistry
,
MD Publications Pvt Ltd
,
Materials Research Society
,
South China University of Technology
,
Springer
,
Qingdao Normal University
,
Progress in Chemistry, Chinese Academy of Sciences
,
Royal Society of Chemistry Cambridge
,
RSC Polymer Chemistry Series, Royal Society of Chemistry
,
Science China: Chemistry, Science China Press
,
Bentham Open
,
American Chemical Society
,
American Biographical Institute
,
American Scientific Publishers Inc
,
Chinese Materials Research Society
,
Chinese Chemical Society and Wiley
,
Chinese Academy of Sciences
,
Chinese Chemical Society and Elsivier
,
Chinese Chemical Society
,
, Special Issue on Functional Polymers for Optoelectronic Applications in Polymer Bulletin
,
AIMS Press
,
Aggregation-induced Emission: Phenomena, Materials and Application Wiley
,
Advances in Polymer Science, Springer
,
Hong Kong University of Science and Technology
,
The Chinese University of Hong Kong, Shenzhen
,
Institute of Chemistry Chinese Academy of Sciences
,
Royal Society of Chemistry
,
International Society for Optical Engineering
,
Executive Committee of the Hong Kong Chapter of the Society of Plastics Engineers
,
Hangzhou Normal University
,
Gordon Research Conferences
,
Dove Medical Press
,
Elsevier BV
,
Elsevier
,
Hong Kong Institution of Science
,
Hong Kong Branch of National Engineering Research Center for Tissue Restoration & Reconstruction, Hong Kong, China
,
Innovation China
,
Higher Education Press and Springer-Verlag GmbH
,
Herbert Publications Ltd.
,
HKUST Shenzhen Research Institute
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Publications
Killing G(+) or G(−) Bacteria? The Important Role of Molecular Charge in AIE‐Active Photosensitizers
Publisher: Wiley
Date: 06-04-2020
Regulating the proximity effect of heterocycle-containing AIEgens
Publisher: Springer Science and Business Media LLC
Date: 24-06-2023
DOI: 10.1038/S41467-023-39479-1
Abstract: Proximity effect, which refers to the low-lying ( n ,π*) and (π,π*) states with close energy levels, usually plays a negative role in the luminescent behaviors of heterocyclic luminogens. However, no systematic study attempts to reveal and manipulate proximity effect on luminescent properties. Here, we report a series of methylquinoxaline derivatives with different electron-donating groups, which show different photophysical properties and aggregation-induced emission behaviors. Experimental results and theoretical calculation reveal the gradually changed energy levels and different coupling effects of the closely related ( n ,π*) and (π,π*) states, which intrinsically regulate proximity effect and aggregation-induced emission behaviors of these luminogens. With the intrinsic nature of heterocycle-containing compounds, they are utilized for sensors and information encryption with dynamic responses to acid/base stimuli. This work reveals both positive and negative impacts of proximity effect in heterocyclic aggregation-induced emission systems and provides a perspective to develop functional and responsive luminogens with aggregation-induced emission properties.
Differentiating Silver Nanoparticles and Ions in Medaka Larvae by Coupling Two Aggregation-Induced Emission Fluorophores
Publisher: American Chemical Society (ACS)
Date: 29-04-2019
Abstract: Although numerous studies have been conducted on the toxicity and biodistribution of AgNPs and corresponding ionic counterparts, it is still debatable whether the toxicity originates from the accumulation of particles within specific organs or is mediated by the dissolved Ag ions. To gain a better insight into the toxic mechanisms of AgNPs, two aggregation-induced emission fluorogens (AIEgens AIEgens-coated AgNPs and a fluorogenic Ag
Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8CS00185E
Abstract: We review recent advances in the design and application of excited-state intramolecular proton-transfer (ESIPT) based fluorescent probes. These sensors and imaging agents (probes) are important in biology, physiology, pharmacology, and environmental science.
Highly efficient photothermal nanoagent achieved by harvesting energy via excited-state intramolecular motion within nanoparticles
Publisher: Springer Science and Business Media LLC
Date: 15-02-2019
DOI: 10.1038/S41467-019-08722-Z
Abstract: The exciting applications of molecular motion are still limited and are in urgent pursuit, although some fascinating concepts such as molecular motors and molecular machines have been proposed for years. Utilizing molecular motion in a nanoplatform for practical application has been scarcely explored due to some unconquered challenges such as how to achieve effective molecular motion in the aggregate state within nanoparticles. Here, we introduce a class of near infrared-absorbing organic molecules with intramolecular motion-induced photothermy inside nanoparticles, which enables most absorbed light energy to dissipate as heat. Such a property makes the nanoparticles a superior photoacoustic imaging agent compared to widely used methylene blue and semiconducting polymer nanoparticles and allow them for high-contrast photoacoustic imaging of tumours in live mice. This study not only provides a strategy for developing advanced photothermal hotoacoustic imaging nanoagents, but also enables molecular motion in a nanoplatform to find a way for practical application.
Endowing AIE with Extraordinary Potential: A New Au(I)‐Containing AIEgen for Bimodal Bioimaging‐Guided Multimodal Synergistic Cancer Therapy
Publisher: Wiley
Date: 05-10-2021
Abstract: The development of high‐performance theranostic platforms is always an intractable challenge in modern medicine research. Herein, new luminescent materials that possess the advantages of high sensitivity, high resolution, and deep tumor‐penetrating imaging as well as multimodal synergistic therapeutic functions may be one of the best potential alternatives for efficient theranostics. In this work, a powerful Au(I)‐containing aggregation‐induce emission luminogen (AIEgen) with integrated multifunctions of bimodal imaging and multimodal combination therapy is developed. This simple small‐molecule system can simultaneously realize high‐contrast fluorescence imaging and computed tomography imaging. Additionally, it can act as an effective thioredoxin reductase inhibitor to exert inherent anticancer effect, and simultaneously work as an ideal radiosensitizer to produce efficient anticancer efficacy through a multimodal synergistic effect. Thus, this study highlights a new design guideline to endow AIE luminogens with extraordinary functions by Au(I) and opens a new avenue for the development of new luminescent theranostic systems.
Visualizing the Initial Step of Self-Assembly and the Phase Transition by Stereogenic Amphiphiles with Aggregation-Induced Emission
Publisher: American Chemical Society (ACS)
Date: 11-12-2018
Abstract: Many highly ordered structures with smart functions are generated by self-assembly with stimuli responsiveness. Despite that electron microscopes enable us to directly observe the end products, it is hard to visualize the initial step and the kinetic stimuli-responsive behavior of self-assembly. Here, we report the design and synthesis of stereogenic hiphiles, namely, ( Z)-TPE-OEG and ( E)-TPE-OEG, with aggregation-induced emission (AIE) characteristics from the hydrophobic tetraphenylethene core and thermoresponsive behavior from the hydrophilic oligoethylene glycol monomethyl ether chain. The two isomers can be easily isolated by high-performance liquid chromatography and characterized by 2D NMR spectroscopy. While ( Z)-TPE-OEG self-assembles into vesicles, its ( E)-cousin forms micelles in water. The initial step of their self-assembly processes can be visualized based on AIE characteristics, with a sensitivity much higher than the method based on transmittance measurement. The entrapment and release capabilities of the ( Z)-stereogenic hiphile are demonstrated by employing pyrene as a guest. The thermoresponsive behavior of the ( Z)- hiphile results in its continuous phase transition from microscopic self-assembly to macroscopic aggregation, which is successfully visualized in situ by confocal laser scanning microscopy accompanied by the AIE technique. Such a kinetic process shows different stages according to the microscopic visualization, and these stages have never been monitored through roughly observing the appearance of precipitates. It is anticipated that this study can deepen the understanding of the self-assembly processes for better monitoring and controlling them in different systems.
Facile synthesis of AIEgens with wide color tunability for cellular imaging and therapy
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8SC05805A
Abstract: Facile synthesis and bio-applications of a series of AIEgens with widely tunable emissions ranging from violet to near-infrared are reported.
Multifunctional Nanoprobe for the Delivery of Therapeutic siRNA and Real-Time Molecular Imaging of Parkinson’s Disease Biomarkers
Publisher: American Chemical Society (ACS)
Date: 08-03-2021
Dynamic Visible Monitoring of Heterogeneous Local Strain Response through an Organic Mechanoresponsive AIE Luminogen
Publisher: American Chemical Society (ACS)
Date: 16-04-2020
Constitutional Isomerization Enables Bright NIR‐II AIEgen for Brain‐Inflammation Imaging
Publisher: Wiley
Date: 18-12-2019
Tunable circularly polarized luminescence from molecular assemblies of chiral AIEgens
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9QM00332K
Abstract: A tunable CPL response is achieved through regulating the aggregated structures of AIEgens in solution and solid states. Interestingly, DPCE-ECh exhibits a smectic C* phase with a high dissymmetry factor ( g CD = −0.20 and g lum = +0.38).
New aggregation-induced delayed fluorescent materials for efficient OLEDs with high stabilities of emission color and efficiency
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1QM01625C
Abstract: New aggregation-induced delayed fluorescence luminogens are developed, which exhibit high electroluminescence efficiencies, very small efficiency roll-offs and high emission color stability.
Specific Targeting, Imaging, and Ablation of Tumor-Associated Macrophages by Theranostic Mannose–AIEgen Conjugates
Publisher: American Chemical Society (ACS)
Date: 22-04-2019
DOI: 10.1021/ACS.ANALCHEM.9B01053
Abstract: Tumor-associated macrophages (TAMs) that exist in tumor microenvironment promote tumor progression and have been suggested as a promising therapeutic target for cancer therapy in preclinical studies. Development of theranostic systems capable of specific targeting, imaging, and ablation of TAMs will offer clinical benefits. Here we constructed a theranostic probe, namely, TPE-Man, by attaching mannose moieties to a red-emissive and AIE (aggregation-induced emission)-active photosensitizer. TPE-Man can specifically recognize a mannose receptor that is overexpressed on TAMs by the sugar-receptor interaction and enables fluorescent visualization of the mannose-receptor-positive TAMs in high contrast. The histologic study of mouse tumor sections further verifies TPE-Man's excellent targeting specificity being comparable with the commercial mannose-receptor antibody. TAMs can be effectively eradicated upon exposure to white light irradiation via a photodynamic therapy effect. To our knowledge, this is the first small molecular theranostic probe for TAMs that revealed combined advantages of low cost, high targeting specificity, fluorescent light-up imaging, and efficient photodynamic ablation.
Design and Synthesis of Luminescent Liquid Crystalline Polymers with “Jacketing” Effect and Luminescent Patterning Applications
Publisher: American Chemical Society (ACS)
Date: 07-05-2019
Synergistic Enhancement of Fluorescence and Magnetic Resonance Signals Assisted by Albumin Aggregate for Dual-Modal Imaging
Publisher: American Chemical Society (ACS)
Date: 07-06-2021
A ratiometric theranostic system for visualization of ONOO− species and reduction of drug-induced hepatotoxicity
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1BM01675J
Abstract: A ratiometric theranostic probe, ATV-PPB, is designed to simultaneously visualize and eliminate ONOO − . Red emissive ATV-PPB originally on mitochondria is transformed to green emissive ATV-Py and translocated to lipid droplets after cleavage by ONOO − .
Recent advances in aggregation-induced emission luminogens in photoacoustic imaging
Publisher: Springer Science and Business Media LLC
Date: 12-03-2022
DOI: 10.1007/S00259-022-05726-8
Abstract: Photoacoustic imaging (PAI) is a rapidly emerging modality in biomedical research with the advantages of noncontact operation, high optical resolution, and deep penetration. Great efforts and progress in the development of PAI agents with improved imaging resolution and sensitivity have been made over the past 2 decades. Among them, organic agents are the most promising candidates for preclinical/clinical applications due to their outstanding in vivo properties and facile biofunctionalities. Motivated by the unique properties of aggregation-induced emission (AIE) luminogens (AIEgens), various optical probes have been developed for bioanalyte detection, multimodal bioimaging, photodynamic hotothermal therapy, and imaging-guided therapeutics. In particular, AIE-active contrast agents have been demonstrated in PAI applications with excellent performance in imaging resolution and tissue permeability in vivo. This paper presents a brief overview of recent progress in AIE-based agents in the field of photoacoustic imaging. In particular, we focus on the basic concepts, data sorting and comparison, developing trends, and perspectives of photoacoustic imaging. Through numerous typical ex les, the way each system realizes the desired photoacoustic performance in various biomedical applications is clearly illustrated. We believe that AIE-based PAI agents would be promising multifunctional theranostic platforms in clinical fields and will facilitate significant advancements in this research topic.
Improving the Efficiency of AIEgen-Based Nondoped Blue Organic Light-Emitting Diode by Rational Isomer Engineering
Publisher: American Chemical Society (ACS)
Date: 06-05-2022
Zwitterionic AIEgens: Rational Molecular Design for NIR‐II Fluorescence Imaging‐Guided Synergistic Phototherapy
Publisher: Wiley
Date: 06-10-2020
Direct Polymerization of Carbon Dioxide, Diynes, and Alkyl Dihalides under Mild Reaction Conditions
Publisher: American Chemical Society (ACS)
Date: 21-12-2017
Antiviral and Anti‐Inflammatory Treatment with Multifunctional Alveolar Macrophage‐Like Nanoparticles in a Surrogate Mouse Model of COVID‐19
Publisher: Wiley
Date: 12-05-2021
Abstract: The pandemic of coronavirus disease 2019 (COVID‐19) is continually worsening. Clinical treatment for COVID‐19 remains primarily supportive with no specific medicines or regimens. Here, the development of multifunctional alveolar macrophage (AM)‐like nanoparticles (NPs) with photothermal inactivation capability for COVID‐19 treatment is reported. The NPs, made by wrapping polymeric cores with AM membranes, display the same surface receptors as AMs, including the coronavirus receptor and multiple cytokine receptors. By acting as AM decoys, the NPs block coronavirus from host cell entry and absorb various proinflammatory cytokines, thus achieving combined antiviral and anti‐inflammatory treatment. To enhance the antiviral efficiency, an efficient photothermal material based on aggregation‐induced emission luminogens is doped into the NPs for virus photothermal disruption under near‐infrared (NIR) irradiation. In a surrogate mouse model of COVID‐19 caused by murine coronavirus, treatment with multifunctional AM‐like NPs with NIR irradiation decreases virus burden and cytokine levels, reduces lung damage and inflammation, and confers a significant survival advantage to the infected mice. Crucially, this therapeutic strategy may be clinically applied for the treatment of COVID‐19 at early stage through atomization inhalation of the NPs followed by NIR irradiation of the respiratory tract, thus alleviating infection progression and reducing transmission risk.
An Ultraviolet Fluorophore with Narrowed Emission via Coplanar Molecular Strategy
Publisher: Wiley
Date: 26-10-2022
Abstract: Narrowband emitting fluorophores exhibit immense potentials for organic light‐emitting diodes (OLEDs) with high color purity. However, it's still hard to simultaneously realize short‐wavelength ultraviolet (UV) or near ultraviolet emission (NUV) while maintaining a narrowed full width at half maximum (FWHM) value, and rare work focus on such challenging pursuit. Herein, an ingenious synthetic method was devised to achieve emitters with coplanar structure. 11‐(4,6‐diphenyl‐1,3,5‐triazin‐2‐yl)indolo[3,2,1‐ jk ]carbazole (ICZ‐TAZ) was designed to realize narrowed UV emission both in photoluminescence (PL) and electroluminescence (EL) which benefited from the suppression of vibronic coupling. UV/NUV OLEDs based on ICZ‐TAZ achieve external quantum efficiency (EQE) maximums of 3.26 % peaks @ 388 nm and 4.02 % peaks @ 406 nm with small FWHM of 32 nm and 46 nm, respectively, corresponding with reduced efficiency roll‐off at luminance of 100 cd m −2 .
Aggregation-Induced Emission Luminogen with Deep-Red Emission for Through-Skull Three-Photon Fluorescence Imaging of Mouse
Publisher: American Chemical Society (ACS)
Date: 12-10-2017
Abstract: Imaging the brain with high integrity is of great importance to neuroscience and related applications. X-ray computed tomography (CT) and magnetic resonance imaging (MRI) are two clinically used modalities for deep-penetration brain imaging. However, their spatial resolution is quite limited. Two-photon fluorescence microscopic (2PFM) imaging with its femtosecond (fs) excitation wavelength in the traditional near-infrared (NIR) region (700-1000 nm) is able to realize deep-tissue and high-resolution brain imaging. However, it requires craniotomy and cranial window or skull-thinning techniques due to photon scattering of the excitation light. Herein, based on a type of aggregation-induced emission luminogen (AIEgen) DCDPP-2TPA with a large three-photon absorption (3PA) cross section at 1550 nm and deep-red emission, we realized through-skull three-photon fluorescence microscopic (3PFM) imaging of mouse cerebral vasculature without craniotomy and skull-thinning. Reduced photon scattering of a 1550 nm fs excitation laser allowed it to effectively penetrate the skull and tightly focus onto DCDPP-2TPA nanoparticles (NPs) in the cerebral vasculature, generating bright three-photon fluorescence (3PF) signals. In vivo 3PF images of the cerebral vasculature at various vertical depths were obtained, and a vivid 3D reconstruction of the vascular architecture beneath the skull was built. As deep as 300 μm beneath the skull, small blood vessels of 2.4 μm could still be recognized.
New Wine in Old Bottles: Prolonging Room‐Temperature Phosphorescence of Crown Ethers by Supramolecular Interactions
Publisher: Wiley
Date: 20-11-2019
Abstract: Supramolecular macrocyclic hosts have long been used in smart materials. However, their triplet emission and regulation at crystal level is rarely studied. Herein, ultralong and universal room-temperature phosphorescence (RTP) is reported for traditional crown ethers. A supramolecular strategy involving chain length adjustment and morphological locking through complexation with K
A New Strategy to Elevate Absorptivity of AIEgens for Intensified NIR‐II Emission and Synergized Multimodality Therapy
Publisher: Wiley
Date: 10-10-2023
Abstract: High‐efficiency absorptivity is crucial for the construction of high‐performance luminescent materials, especially the long‐wavelength near‐infrared II (NIR‐II) materials, thus seeking an efficient and universal strategy to elevate the absorptivity is extremely important but is still an intractable challenge. In this work, we discovered a simple but efficient design strategy involving the introduction of gold(I) unit that could effectively elevate the absorptivity of aggregation‐induced emission luminogens (AIEgens). As a result of the efficient elevation of absorptivity, the representative AIE‐active TBTP‐Au showed more superior NIR‐II (1220 nm) luminescence, much higher photothermal conversion efficiency, and unique intracellular reactive oxygen species generating ability compared with that of the TBTP ligand. Take advantage of these improvements, the fabricated tumor‐targeting TBTP‐Au‐cRGD nanoparticles achieved specific NIR‐II tumorous imaging in vivo and exerted high‐efficiency cancer therapy via the synergistic chemotherapy and photothermal therapy. Thus, this work provides a new and efficient strategy to construct high‐absorption luminescent materials and demonstrates the great potential of gold(I)‐based AIEgens as multifunctional theranostic agents. This article is protected by copyright. All rights reserved
Wash-free detection and bioimaging by AIEgens
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0QM00586J
Abstract: Herein, the latest progress of AIEgens for application in wash-free detection and bioimaging was reviewed.
AIE-Enabled In Situ and Real-Time Visualization of Polymer Growth during Interfacial Polymerization
Publisher: American Chemical Society (ACS)
Date: 07-07-2023
Anion–π Type Aggregation‐Induced Emission Luminogens
Publisher: Wiley
Date: 13-02-2023
Abstract: As a type of important non‐covalent interactions that can efficiently prohibit π–π interaction to avoid quenching of luminescence, anion–π interactions are receiving growing attention for the fabrication of aggregation‐induced emission luminogens (AIEgens) since 2017. The obtained anion–π type AIEgens can be applied in the fields of wash‐free bioimaging and long‐term tracking of subcellular organelle, photodynamic anti‐cancer and anti‐bacterial therapy due to their good water solubility, superior photostability and excellent reactive oxygen species generation ability. Moreover, anion–π type AIEgens were also further constructed for room temperature phosphorescence by taking advantages of the heavy‐atom participated anion–π interactions. This concept article provides a brief summary of this field, mainly focusing on the design strategy, photophysical properties and applications of anion–π type AIEgens.
Rational Design of Perylenediimide‐Substituted Triphenylethylene to Electron Transporting Aggregation‐Induced Emission Luminogens (AIEgens) with High Mobility and Near‐Infrared Emission
Publisher: Wiley
Date: 17-01-2018
Economic Sulfur Conversion to Functional Polythioamides through Catalyst-Free Multicomponent Polymerizations of Sulfur, Acids, and Amines
Publisher: American Chemical Society (ACS)
Date: 16-12-2020
DOI: 10.1021/JACS.9B11066
Abstract: Sulfur utilization is a global concern because of its abundant nature sources and the safety or environmental problems caused by its burning or oxidation during storage, while sulfur-containing polymers are popular materials in virtue of their fascinating properties such as metal coordination ability, high refractive indices, and semiconducting property. The synthesis of sulfur-containing polymers is challenging, especially directly from elemental sulfur. Herein, catalyst-free and scalable multicomponent polymerizations (MCPs) of all commercially available elemental sulfur, dicarboxylic acids, and diamines were reported to facilely construct 12 polythioamides with erse and well-defined structures, high molecular weights (
Functional Built-In Template Directed Siliceous Fluorescent Supramolecular Vesicles as Diagnostics
Publisher: American Chemical Society (ACS)
Date: 23-06-2017
Abstract: Functional template directed synthesis of hybrid siliceous fluorescent vesicle (HSFV) is fabricated by using fluorescent vesicle as a built-in template. The template vesicle is the ionic self-assembly of an aggregation-induced emission (AIE) fluorogen. Upon depositing folic acid modified silica shell on its surface, the obtained HSFVs display low cytotoxicity, significant fluorescence, and targeted drug delivery toward cancer cells. Furthermore, the wall-thickness of the HSFVs can be controlled via altered concentration of silica source. This is the first report of HSFV employing the template vesicle as a built-in fluorescent agent, which represents a good ex le of rational design for an effective diagnostics, and may open up a new avenue for precision medicine.
Structural and process controls of AIEgens for NIR-II theranostics
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0SC02911D
Abstract: Structural and process controls of NIR-II AIEgens realize manipulating of radiative (R) and nonradiative (NR) decay for precise theranostics.
Frontispiz: A Conjugated Polymeric Supramolecular Network with Aggregation‐Induced Emission Enhancement: An Efficient Light‐Harvesting System with an Ultrahigh Antenna Effect
Publisher: Wiley
Date: 05-06-2020
Manipulating the Molecular Backbone to Achieve Highly Emissive Sky‐Blue AIEgens and Their Applications in Nondoped Organic Light‐Emitting Diodes
Publisher: Wiley
Date: 07-08-2018
Multicomponent Polymerization of Alkynes, Isocyanides, and Isocyanates toward Heterocyclic Polymers
Publisher: American Chemical Society (ACS)
Date: 08-07-2021
Dramatic Differences in Aggregation-Induced Emission and Supramolecular Polymerizability of Tetraphenylethene-Based Stereoisomers
Publisher: American Chemical Society (ACS)
Date: 18-07-2017
DOI: 10.1021/JACS.7B05792
Abstract: Geometric (Z)- and (E)-isomers play important but different roles in life and material science. The design of new (Z)-/(E)- isomers and study of their properties, behaviors, and interactions are crucially important in molecular engineering. However, difficulties with their separation and structure confirmation limit their structural ersity and functionality in scope. In the work described herein, we successfully synthesized pure isomers of ureidopyrimidinone-functionalized tetraphenylethenes ((Z)-TPE-UPy and (E)-TPE-UPy), featuring both the aggregation-induced emission characteristic of tetraphenylethene and the supramolecular polymerizability of ureidopyrimidinone. Their structures were confirmed by 2D COSY and NOESY NMR spectroscopies. The two isomers show distinct fluorescence in the aggregate state: (Z)-TPE-UPy exhibits green emission, while its (E)-counterpart is blue-emitting. The cavity formed by the two ureidopyrimidinone groups of (Z)-TPE-UPy makes it suitable for Hg
Highly Efficient Photosensitizers with Far‐Red/Near‐Infrared Aggregation‐Induced Emission for In Vitro and In Vivo Cancer Theranostics
Publisher: Wiley
Date: 22-08-2018
Abstract: Fluorescence-imaging-guided photodynamic therapy has emerged as a promising protocol for cancer theranostics. However, facile preparation of such a theranostic material for simultaneously achieving bright emission with long wavelength, high-performance reactive oxygen species (ROS) generation, and good targeting-specificity of cancer cells, is highly desirable but remains challenging. In this study, a novel type of far-red/near-infrared-emissive fluorescent molecules with aggregation-induced emission (AIE) characteristics is synthesized through a few steps reaction. These AIE luminogens (AIEgens) possess simple structures, excellent photostabilities, large Stokes shifts, bright emission, and good biocompatibilities. Meanwhile, their ROS generation is extremely efficient with up to 90.7% of ROS quantum yield, which is far superior to that of some popularly used photosensitizers. Importantly, these AIEgens are able to selectively target and ablate cancer cells over normal cells without the aid of any extra targeting ligands. Rather than using laser light, one of the presented AIEgens (MeTTPy) shows a remarkable tumor-targeting photodynamic therapeutic effect by using an ultralow-power l light (18 mW cm
CO2-Involved and Isocyanide-Based Three-Component Polymerization toward Functional Heterocyclic Polymers with Self-Assembly and Sensing Properties
Publisher: American Chemical Society (ACS)
Date: 19-04-2021
A facile strategy for realizing room temperature phosphorescence and single molecule white light emission
Publisher: Springer Science and Business Media LLC
Date: 27-07-2018
DOI: 10.1038/S41467-018-05298-Y
Abstract: Research on materials with pure organic room temperature phosphorescence (RTP) and their application as organic single-molecule white light emitters is a hot area and relies on the design of highly efficient pure organic RTP luminogens. Herein, a facile strategy of heavy-atom-participated anion–π + interactions is proposed to construct RTP-active organic salt compounds (1,2,3,4-tetraphenyloxazoliums with different counterions). Those compounds with heavy-atom counterions (bromide and iodide ions) exhibit outstanding RTP due to the external heavy atom effect via anion–π + interactions, evidently supported by the single-crystal X-ray diffraction analysis and theoretical calculation. Their single-molecule white light emission is realized by tuning the degree of crystallization. Such white light emission also performs well in polymer matrices and their use in 3D printing is demonstrated by white light l shades.
Solution‐processed AIEgen NIR OLEDs with EQE Approaching 15 %
Publisher: Wiley
Date: 28-04-2022
Abstract: Organic near‐infrared (NIR) luminogens have attracted intensive attention considering their vast potential applications in areas like bioimaging, organic light‐emitting diodes (OLEDs) and night‐vision telecommunication. However, organic NIR luminogens with high solid quantum efficiencies are scarce, limiting their applications. Here, we reported an electron‐deficient acceptor, BSM, based on dithiafulvalene and benzothiadiazole, which could work as a strong acceptor to produce highly efficient NIR emitters with aggregation‐induced emission (AIE) property. One of the AIEgens, TBSMCN emitted at 820 nm with a solid quantum yield of 10.7 %. When applied to solution‐processed OLEDs, an outstanding external quantum efficiency (EQE) of 9.4 % was achieved with a peak wavelength at 728 nm. Moreover, its non‐doped device could achieve an extraordinary EQE of 2.2 % peaking at 804 nm. In the further optimized configuration, when an extra sensitizer was added to harvest triplet excitons, the EQE unprecedentedly soared up to 14.3 % with a peak wavelength of 750 nm.
Photo-induced crystallization with emission enhancement (PICEE)
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0MH01200A
Abstract: A new photoactivation mechanism, photo-induced crystallization with emission enhancement, is developed based on an isoquinolinium salt with applications in mitochondria-targeting and photodynamic therapy.
Insight from the old: mechanochromism and mechanoluminescence of two amine-containing tetraphenylethylene isomers
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9TC04140K
Abstract: The mechanochromism (MC) and mechanoluminescence (ML) properties of an “old” tetraphenylethylene derivative p-NH2 and its isomer m-NH2 were investigated.
AIEgen-based smart system for fungal-infected wound monitoring and on-demand photodynamic therapy
Publisher: Elsevier BV
Date: 10-2023
Making the Best Use of Excited-State Energy: Multimodality Theranostic Systems Based on Second Near-Infrared (NIR-II) Aggregation-Induced Emission Luminogens (AIEgens)
Publisher: American Chemical Society (ACS)
Date: 20-07-2020
Tumor‐Exocytosed Exosome/Aggregation‐Induced Emission Luminogen Hybrid Nanovesicles Facilitate Efficient Tumor Penetration and Photodynamic Therapy
Publisher: Wiley
Date: 03-06-2020
Abstract: The development of novel photosensitizing agents with aggregation‐induced emission (AIE) properties has fueled significant advances in the field of photodynamic therapy (PDT). An electroporation method was used to prepare tumor‐exocytosed exosome/AIE luminogen (AIEgen) hybrid nanovesicles (DES) that could facilitate efficient tumor penetration. Dexamethasone was then used to normalize vascular function within the tumor microenvironment (TME) to reduce local hypoxia, thereby significantly enhancing the PDT efficacy of DES nanovesicles, and allowing them to effectively inhibit tumor growth. The hybridization of AIEgen and biological tumor‐exocytosed exosomes was achieved for the first time, and combined with PDT approaches by normalizing the intratumoral vasculature as a means of reducing local tissue hypoxia. This work highlights a new approach to the design of AIEgen‐based PDT systems and underscores the potential clinical value of AIEgens.
Fluorescence ratiometric assay for discriminating GSH and Cys based on the composites of UiO-66-NH2 and Cu nanoclusters
Publisher: Elsevier BV
Date: 11-2022
DOI: 10.1016/J.BIOS.2022.114582
Abstract: The discriminative detection of glutathione (GSH) from cysteine (Cys) remains a challenge because of their similarity in structure and chemical properties. This study reported a strategy for selective and sensitive detection of GSH based on the GSH-promoted blue fluorescence of UiO-66-NH
Robust Supramolecular Nano‐Tunnels Built from Molecular Bricks**
Publisher: Wiley
Date: 09-02-2021
Intracellular trafficking of silver nanoparticles and silver ions determined their specific mitotoxicity to the zebrafish cell line
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1EN00021G
Abstract: AgNP toxicity was attributed to dissolved Ag + , which was released, transported, and concentrated in the mitochondria, finally leading to exhaustion of the reserve respiratory capacity and cell death.
Non-aromatic annulene-based aggregation-induced emission system via aromaticity reversal process
Publisher: Springer Science and Business Media LLC
Date: 04-07-2019
DOI: 10.1038/S41467-019-10818-5
Abstract: Aggregation-induced emission (AIE) is a photophysical phenomenon correlated closely with the excited-state intramolecular motions. Although AIE has attracted increasing attention due to the significant applications in biomedical and optoelectronics, an in-depth understanding of the excited-state intramolecular motion has yet to be fully developed. Here we found the non-aromatic annulene derivative of cyclooctatetrathiophene shows typical AIE phenomenon in spite of its rotor-free structure. The underlying mechanism is investigated through photoluminescence spectra, time-resolved absorption spectra, theoretical calculations, circular dichroism as well as by pressure-dependent fluorescent spectra etc., which indicate that the aromaticity reversal from ground state to the excited state serves as a driving force for inducing the excited-state intramolecular vibration, leading to the AIE phenomenon. Therefore, aromaticity reversal is demonstrated as a reliable strategy to develop vibrational AIE systems. This work also provides a new viewpoint to understand the excited-state intramolecular motion behavior of lumiongens.
Imidazole-based Cu(i )-catalyzed click polymerization of diazides and diynes under mild conditions
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0PY01675F
Abstract: An efficient imidazole-based Cu( i )-catalyzed azide–alkyne click polymerization under mild reaction conditions was developed.
Multifunctional AuI‐based AIEgens: Manipulating Molecular Structures and Boosting Specific Cancer Cell Imaging and Theranostics
Publisher: Wiley
Date: 05-03-2020
Abstract: Gold(I) N‐heterocyclic carbene (Au I ‐NHC) complexes have emerged as potential anticancer agents owing to their high cytotoxicity and stability. Integration of their above unique functions with customized aggregation‐induced emission (AIE) luminogens to achieve specific bioimaging and efficient theranostics to cancer is highly desirable but is rarely studied. Now, a series of novel Au I ‐NHC compounds were developed with AIE characteristics. A complex with a PPh 3 ligand was selected out as it could achieve both prominent specific imaging of various cancer cells and efficient inhibition of their growth with negligible toxic effects on normal cells due to the targeting binding and strong inhibition towards thioredoxin reductase. This complex could also act as a powerful radiosensitizer to boost the anticancer efficacy with performance superior to that of popularly used auranofin. It holds great potential as a specific and effective theranostic drug in cancer diagnosis and precise therapy.
AIEgen-Based Polymer Nanocomposites for Imaging-Guided Photothermal Therapy
Publisher: American Chemical Society (ACS)
Date: 06-09-2020
In situ generation of photoactivatable aggregation-induced emission probes for organelle-specific imaging
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8SC01887A
Abstract: Photoactivatable fluorescent probes are ideal tools for organelle study with a significant advantage of high spatiotemporal resolution.
In vivomonitoring of tissue regeneration using a ratiometric lysosomal AIE probe
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9SC06226B
Abstract: An AIE-active ratiometric probe for the first time achieved the long-term quantification of lysosomal pH during the medaka larva's caudal fin regeneration.
Development of AIEgen–montmorillonite nanocomposite powders for computer-assisted visualization of latent fingermarks
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0QM00059K
Abstract: AIE–active montmorillonite nanocomposite powders (AIE–MMT) were developed for computer-assistant latent fingerprint (LFP) imaging.
An Easily Accessible Ionic Aggregation‐Induced Emission Luminogen with Hydrogen‐Bonding‐Switchable Emission and Wash‐Free Imaging Ability
Publisher: Wiley
Date: 23-03-2018
Abstract: Ionic fluorophores are powerful tools for the study of environmental science and bio-imaging. However, traditional ionic dyes usually require long synthetic steps and suffer from a quenching effect caused by aggregation. A water-soluble ionic aggregation-induced emission luminogen called DBTA is presented, which is readily accessed by a one-step reaction. The switchable emission manipulated by hydrogen bonding provided solid evidence for the restriction of intramolecular motions as the mechanism of aggregation-induced emission. DBTA can not only differentiate solvents with different H-bond donor acidities but also capable of wash-free imaging in living HeLa cells and fish larva.
Ethynylsulfone-Based Spontaneous Amino-yne Click Polymerization: A Facile Tool toward Regio- and Stereoregular Dynamic Polymers
Publisher: American Chemical Society (ACS)
Date: 11-06-2019
Multimodal Imaging‐Guided Photothermal Immunotherapy Based on a Versatile NIR‐II Aggregation‐Induced Emission Luminogen
Publisher: Wiley
Date: 05-05-2022
Abstract: Synergistic photothermal immunotherapy has captured great attention owing to the mutually strengthening therapeutic outcomes towards both original tumors and abscopal tumors. Herein, a versatile theranostic agent displaying aggregation‐induced emission, namely TPA‐BT‐DPTQ, was designed and prepared based on benzo[ c ]thiophene unit as a building block it can be used for simultaneous fluorescence imaging (FLI) in the second near‐infrared (NIR‐II) window, photoacoustic imaging (PAI), photothermal imaging (PTI), and thermal eradication of tumors. Further experiments validate that photothermal therapy (PTT) mediated by TPA‐BT‐DPTQ nanoparticles not only destroys the primary tumor but also enhances immunogenicity for further suppressing the growth of tumors at distant sites. Furthermore, PTT combining a programmed death‐ligand 1 (PD‐L1) antibody prevents the metastasis and recurrence of cancer by potentiating the effect of immunotherapy.
Exosome‐Mimetic Supramolecular Vesicles with Reversible and Controllable Fusion and Fission**
Publisher: Wiley
Date: 17-09-2020
Reaction-based chiroptical sensing of ClO− using circularly polarized luminescence via self-assembly organogel
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9CC05245C
Abstract: A chiral amino acid functionalized probe, PTZ-D, could self-assemble into a chiral organogel displaying unprecedented chiroptical monitoring of ClO − with switchable CPL signals.
Visualizing semipermeability of the cell membrane using a pH-responsive ratiometric AIEgen
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0SC02097D
Abstract: By utilizing a pH-responsive ratiometric AIEgen, dihydro berberine (dhBBR), ion trapping phenomenon was successfully visualized.
Highly efficient deep-blue fluorescent OLEDs based on anthracene derivatives with a triplet–triplet annihilation mechanism
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1QM00880C
Abstract: New deep-blue molecules compromised of tert -butyl modified anthracene, p -benzonitrile, and carbazole derivatives provide external quantum yields of 7.03% and 7.28% in non-doped and doped deep-blue OLEDs, respectively.
A Self‐Reporting Fluorescent Salicylaldehyde–Chlorambucil Conjugate as a Type‐II ICD Inducer for Cancer Vaccines
Publisher: Wiley
Date: 08-08-2022
Abstract: Immunogenic cell death (ICD) can activate the anticancer immune response and is highly attractive to improve cancer treatment efficacy. ICD is closely related to endoplasmic reticulum (ER) stress, and a series of ICD inducers has recently been reported based on ER‐targeted photodynamic hotothermal agents or metal complexes. However, these ER‐targeted ICD inducers suffer from complicated synthesis and heavy‐metal cytotoxicity. Inspired by the promising clinical potential of small organic molecules, herein, an ER‐targeted fluorescent self‐reporting ICD inducer, SA‐Cbl, is developed by simple conjugation of the chemotherapeutic drug chlorambucil (Cbl) with salicylaldehyde (SA). SA‐Cbl can selectively accumulate in the ER to induce rapid ROS generation and an unfolded protein response process, which leads to a fast release of damage‐associated molecular patterns and efficient dendritic cells maturation. Meanwhile, the ER‐targeted accumulation and ER‐stress‐inducing process can be in situ monitored based on the turn‐on fluorescence of SA‐Cbl, which is highly pH‐ and polarity‐sensitive and can selectively interact with ER proteins. Compared with the traditional chemotherapy drug doxorubicin, the superior anticancer immunity effect of SA‐Cbl is verified via an in vivo tumor model. This study thus provides a new strategy for developing fluorescent self‐reporting ICD inducers by decoration of chemotherapeutic drugs with pH and polarity‐sensitive organic fluorophores.
A DNA tetrahedron-loaded natural photosensitizer with aggregation-induced emission characteristics for boosting fluorescence imaging-guided photodynamic therapy
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1QM00420D
Abstract: A natural AIE-active PS (PaH) is utilized to bind into DNA-T for cancer theranostics. The constructed PaH@DNA-T exhibits highly boosted fluorescence intensity and ROS generation, as well as much higher cell uptake efficiency.
Innenrücktitelbild: Heteroaromatic Hyperbranched Polyelectrolytes: Multicomponent Polyannulation and Photodynamic Biopatterning (Angew. Chem. 35/2021)
Publisher: Wiley
Date: 21-06-2021
Tunable Room Temperature Phosphorescence in Heavy-Atom-Free Metal–Organic Frameworks by Ligand Functionalization
Publisher: American Chemical Society (ACS)
Date: 05-09-2023
Molecular Motion in Aggregates: Manipulating TICT for Boosting Photothermal Theranostics
Publisher: American Chemical Society (ACS)
Date: 13-03-2019
DOI: 10.1021/JACS.8B13889
Abstract: Planar donor and acceptor (D-A) conjugated structures are generally believed to be the standard for architecting highly efficient photothermal theranostic agents, in order to restrict intramolecular motions in aggregates (nanoparticles). However, other channels of extra nonradiative decay may be blocked. Now this challenge is addressed by proposing an "abnormal" strategy based on molecular motion in aggregates. Molecular rotors and bulky alkyl chains are grafted to the central D-A core to lower intermolecular interaction. The enhanced molecular motion favors the formation of a dark twisted intramolecular charge transfer state, whose nonradiative decay enhances the photothermal properties. Result shows that small-molecule NIRb14 with long alkyl chains branched at the second carbon exhibits enhanced photothermal properties compared with NIRb6, with short branched chains, and much higher than NIR6, with short linear chains, and the commercial gold nanorods. Both in vitro and in vivo experiments demonstrate that NIRb14 nanoparticles can be used as nanoagents for photoacoustic imaging-guided photothermal therapy. Moreover, charge reversal poly(β-amino ester) makes NIRb14 specifically accumulate at tumor sites. This study thus provides an excited molecular motion approach toward efficient phototheranostic agents.
Stereotactic Photodynamic Therapy Using a Two‐Photon AIE Photosensitizer
Publisher: Wiley
Date: 13-11-2019
Abstract: Two-photon photodynamic therapy (TP-PDT) is emerging as a powerful strategy for stereotactic targeting of diseased areas, but ideal photosensitizers (PSs) are currently lacking. This work reports a smart PS with aggregation-induced emission (AIE) feature, namely DPASP, for TP-PDT with excellent performances. DPASP exhibits high affinity to mitochondria, superior photostability, large two-photon absorption cross section as well as efficient reactive oxygen species generation, enabling it to achieve photosensitization both in vitro and in vivo under two-photon excitation. Moreover, its capability of stereotactic ablation of targeted cells with high-precision is also successfully demonstrated. All these merits make DPASP a promising TP-PDT candidate for accurate ablation of abnormal tissues with minimal damages to surrounding areas in the treatment of various diseases.
Pyrene-based aggregation-induced emission luminogens (AIEgen): structure correlated with particle size distribution and mechanochromism
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9TC01665A
Abstract: The morphology of pyrene-based AIEgens changes depending on the water fraction. The different size distribution and morphological changes of nano-particle species play a significant role in enhancing the emission intensity in the aggregated state.
An All‐Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging‐Guided Synergistic Therapy
Publisher: Wiley
Date: 21-07-2020
Bright red aggregation-induced emission nanoparticles for multifunctional applications in cancer therapy
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9SC06310B
Abstract: Developing multifunctional photosensitizers (PSs) is needed to effectively simplify cancer treatment, but it remains a big challenge.
High-Performance Near-Infrared Aggregation-Induced Emission Luminogen with Mitophagy Regulating Capability for Multimodal Cancer Theranostics
Publisher: American Chemical Society (ACS)
Date: 29-11-2021
Abstract: The construction of intelligent near-infrared (NIR) fluorophores for high specificity to cancer cells and application in multiple therapeutic modalities is crucial for precise cancer diagnostic and therapy. In this study, an aggregation-induced emission-active NIR fluorophore (TACQ) with mitophagy-modulating activity was synthesized and developed for mitochondrial targeting multimodal cancer theranostics. The strengthened push-pull interaction extended the emission of TACQ into the NIR-II region (>1000 nm). Further, the rotor structure and twisted molecular conformation enables nanoaggregates of TACQ to balance the radiative and nonradiative decays to simultaneously exhibit bright NIR emission, high photothermal conversion efficiency (55%), and efficient generation of reactive oxygen species. The lipocationic property of TACQ allows it to selectively accumulate in the mitochondria of cancer cells. TACQ can induce mitophagy and block mitophagic flux facilitating cancer cell apoptosis. Both
Ultrasensitive Virion Immunoassay Platform with Dual-Modality Based on a Multifunctional Aggregation-Induced Emission Luminogen
Publisher: American Chemical Society (ACS)
Date: 27-08-2018
Abstract: Sensitive and accurate detection of highly contagious virus is urgently demanded for disease diagnosis and treatment. Herein, based on a multifunctional aggregation-induced emission luminogen (AIEgen), a dual-modality readout immunoassay platform for ultrasensitive detection of viruses has been successfully demonstrated. The platform is relied on virions immuno-bridged enzymatic hydrolysis of AIEgen, accompanying with the in situ formation of highly emissive AIE aggregates and shelling of silver on gold nanoparticles. As a result, robust turn-on fluorescence and naked-eye discernible plasmonic colorimetry composed dual-signal is achieved. By further taking advantage of effective immunomagnetic enrichment, EV71 virions, as an ex le, can be specifically detected with a limit of detection down to 1.4 copies/μL under fluorescence modality. Additionally, semiquantitative discerning of EV71 virions is realized in a broad range from 1.3 × 10
Cascade C–H-Activated Polyannulations toward Ring-Fused Heteroaromatic Polymers for Intracellular pH Mapping and Cancer Cell Killing
Publisher: American Chemical Society (ACS)
Date: 23-06-2022
DOI: 10.1021/JACS.2C04032
Abstract: The development of straightforward and efficient synthetic methods toward ring-fused heteroaromatic polymers with attractive functionalities has great significance in both chemistry and materials science. Herein, we develop a facile cascade C-H-activated polyannulation route that can in situ generate multiple ring-fused aza-heteroaromatic polymers from readily available monomers in an atom-economical manner. A series of complex polybenzimidazole derivatives with high absolute molecular weights of up to 24 000 are efficiently produced in high yields within 2 h. Benefiting from their unique imidazole-containing ring-fused structures with multiple aryl pendants, the obtained polymers show excellent thermal and morphological stability, good solution processability, high refractive index, small chromic dispersion, as well as remarkable acid-base-responsive fluorescence. Taking advantage of the ratiometric fluorescence response of the triphenylamine-substituted heteroaromatic polymer to pH variations, we successfully apply it as a sensitive fluorescence probe for the mapping and quantitative analysis of intracellular pH in live cells. Furthermore, through the simple
Aggregation‐Induced Emission Macromolecular Materials for Antibacterial Applications
Publisher: Wiley
Date: 05-05-2023
Abstract: Recent advancements in aggregation‐induced emission (AIE) macromolecular materials have brought their attention as potential antibacterial solutions, these materials offer new approaches to cure multidrug‐resistant infections and biofilms in bacterial infections as well as real‐time monitoring and specific targeting of bacteria. This review provides an overview of the three main categories of AIE macromolecular materials with antibacterial properties namely AIE‐active polymers, AIEgen@polymer complexes, and clusterization‐triggered emission (CTE) based polymers. The mechanisms and applications of these materials in antibacterial treatment, wound care, and protective equipment are also discussed. The potential for future developments and application directions of AIE‐based antimicrobial materials are finally highlighted.
The Bioimaging Story of AIEgens
Publisher: American Chemical Society (ACS)
Date: 03-07-2023
DOI: 10.1021/CBMI.3C00056
Synchronously Manipulating Absorption and Extinction Coefficient of Semiconducting Polymers via Precise Dual‐Acceptor Engineering for NIR‐II Excited Photothermal Theranostics
Publisher: Wiley
Date: 12-04-2023
Abstract: Integrating the ultralong excitation wavelength, high extinction coefficient, and prominent photothermal conversion ability into a single photothermal agent is an appealing yet significantly challenging task. Herein, a precise dual‐acceptor engineering strategy is exploited for this attempt based on donor‐acceptor (D‐A) type semiconductor polymers by subtly regulating the molar proportions of the two employed electron acceptor moieties featuring different electronic affinity and π‐conjugation degrees, and making full use of the active intramolecular motion‐induced photothermal effect. The optimal polymer SP4 synchronously shows desirable second near‐infrared (NIR‐II) absorption, an extremely high extinction coefficient, and satisfactory photothermal conversion behavior. Consequently, the unprecedented performance of SP4 NPs on 1064 nm laser‐excited photoacoustic imaging (PAI)‐guided photothermal therapy (PTT) is demonstrated by the precise tumor diagnosis and complete tumor elimination.
Real-Time Monitoring of Hierarchical Self-Assembly and Induction of Circularly Polarized Luminescence from Achiral Luminogens
Publisher: American Chemical Society (ACS)
Date: 05-03-2019
Abstract: Constructing artificial helical structures through hierarchical self-assembly and exploring the underlying mechanism are important, and they help gain insight from the structures, processes, and functions from the biological helices and facilitate the development of material science and nanotechnology. Herein, the two enantiomers of chiral Au(I) complexes ( S)-1 and ( R)-1 were synthesized, and they exhibited impressive spontaneous hierarchical self-assembly transitions from vesicles to helical fibers. An impressive chirality inversion and lification was accompanied by the assembly transition, as elucidated by the results of in situ and time-dependent circular dichroism spectroscopy and scanning electron microscope imaging. The two enantiomers could serve as ideal chiral templates to co-assemble with other achiral luminogens to efficiently induce the resulting co-assembly systems to show circularly polarized luminescence (CPL). Our work has provided a simple but efficient way to explore the sophisticated self-assembly process and presented a facile and effective strategy to fabricate architectures with CPL properties.
Mapping the Regioisomeric Space and Visible Color Range of Purely Organic Dual Emitters with Ultralong Phosphorescence Components: From Violet to Red Towards Pure White Light
Publisher: Wiley
Date: 07-12-2022
Abstract: We mapped the entire visible range of the electromagnetic spectrum and achieved white light emission (CIE: 0.31, 0.34) by combining the intrinsic ns‐fluorescence with ultralong ms‐phosphorescence from purely organic dual emitters. We realized small molecular materials showing high photoluminescence quantum yields (Φ L ) in the solid state at room temperature, achieved by active exploration of the regioisomeric substitution space. Chromophore stacking‐supported stabilization of triplet excitons with assistance from enhanced intersystem crossing channels in the crystalline state played the primary role for the ultra‐long phosphorescence. This strategy covers the entire visible spectrum, based on organic phosphorescent emitters with versatile regioisomeric substitution patterns, and provides a single molecular source of white light with long lifetime (up to 163.5 ms) for the phosphorescent component, and high overall photoluminescence quantum yields (up to Φ L =20 %).
Design of One-for-All Near-Infrared Aggregation-Induced Emission Nanoaggregates for Boosting Theranostic Efficacy
Publisher: American Chemical Society (ACS)
Date: 03-2023
Two Are Better Than One: A Design Principle for Ultralong‐Persistent Luminescence of Pure Organics
Publisher: Wiley
Date: 22-04-2020
Bis(hexamethylazatriangulene)sulfone: a high-stability deep blue-violet fluorophore with 100% quantum yield and CIEy < 0.07
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9TC05938E
Abstract: Efficient deep blue-violet fluorophores are highly sought after as emitters for OLEDs and as labels for fluorescent imaging.
Aggregation-induced barrier to oxygen—a new AIE mechanism for metal clusters with phosphorescence
Publisher: Oxford University Press (OUP)
Date: 30-11-2022
DOI: 10.1093/NSR/NWAB216
Abstract: Metal clusters are useful phosphors, but highly luminescent ex les are quite rare. Usually, the phosphorescence of metal clusters is hindered by ambient O2 molecules. Transforming this disadvantage into an advantage for meaningful applications of metal clusters presents a formidable challenge. In this work, we used ligand engineering to judiciously prepare colour-tuneable and brightly emitting Cu(I) clusters that are ultrasensitive to O2 upon dispersion in a fluid solution or in a solid matrix. When the O2 scavenger dimethyl sulfoxide (DMSO) was used as the solvent, joint photo- and oxygen-controlled multicolour switches were achieved for the first time for metal cluster-based photopatterning and photo-anticounterfeiting. More importantly, an aggregation-induced barrier to oxygen, a new aggregation-induced emission mechanism for metal clusters, was proposed, providing a new pathway to realizing the intense emission of metal clusters in the aggregated state. These results are expected to promote the application of metal clusters and enrich the luminescence theory of metal cluster aggregates.
Multifunctional Linear and Hyperbranched Five-Membered Cyclic Carbonate-Based Polymers Directly Generated from CO2 and Alkyne-Based Three-Component Polymerization
Publisher: American Chemical Society (ACS)
Date: 17-07-2019
Complete Degradation of a Conjugated Polymer into Green Upcycling Products by Sunlight in Air
Publisher: American Chemical Society (ACS)
Date: 28-06-2021
DOI: 10.1021/JACS.1C04611
Abstract: The rapid development of digital society and artificial intelligence has triggered explosive demands for specialty plastics, especially conjugated polymers that are instrumental for flexible electronics and smart devices. The recycling and degradation of postconsumer conjugated polymers have become more important than ever to reduce the pressure to the environment. Here we report the discovery of an environmentally self-degradable conjugated polymer poly(deca-4,6-diynedioic acid), or PDDA. PDDA is stable in the dark or without oxygen when used as a functional material. However, when exposed to sunlight and air after the service life, PDDA disintegrates rapidly and fully decomposes through photooxidation in a week, yielding biocompatible, value-added succinic acid as a major degradation product. The complete degradation of PDDA into green upcycling products by sunlight in air, without leaving any microplastics, not only renders a pioneering paradigm of environmentally self-degradable conjugated polymers but also inspires developing effective strategies to completely degrade postconsumer conjugated polymers in a natural environment.
Mitochondria‐ and Lysosomes‐Targeted Synergistic Chemo‐Photodynamic Therapy Associated with Self‐Monitoring by Dual Light‐Up Fluorescence
Publisher: Wiley
Date: 14-09-2018
Fused Heterocyclic Polymers with Aggregation-Induced Emission: Synthesis and Applications
Publisher: American Chemical Society (ACS)
Date: 13-01-2022
Aggregation behaviour of pyrene-based luminescent materials, from molecular design and optical properties to application
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3CS00251A
A biocompatible dual-AIEgen system without spectral overlap for quantitation of microbial viability and monitoring of biofilm formation
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1MH00149C
Abstract: A dual-AIEgen system for microbial imaging and metabolic status sensing has been realized through chemistry strategies. This dual-AIEgen system can detect general microbes and identify their viabilities as well as their microbial biofilms.
Super-Resolution Visualization of Self-Assembling Helical Fibers Using Aggregation-Induced Emission Luminogens in Stimulated Emission Depletion Nanoscopy
Publisher: American Chemical Society (ACS)
Date: 04-10-2019
Abstract: Organic fluorophores for stimulated emission depletion (STED) nanoscopy usually suffer from quenched emission in the aggregate state and inferior photostability, which largely limit their application in real-time,
Room temperature synthesis of polythioamides from multicomponent polymerization of sulfur, pyridine-activated alkyne, and amines
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1CC06448G
Abstract: Through the design of a pyridine-activated diyne monomer, the catalyst-free multicomponent polymerizations of sulfur, aromatic alkyne, and a group of commercially available primary and secondary diamines were realized at room temperature or 40 °C.
Rational Design of Circularly Polarized Luminescent Aggregation-Induced Emission Luminogens (AIEgens): Promoting the Dissymmetry Factor and Emission Efficiency Synchronously
Publisher: American Chemical Society (ACS)
Date: 07-04-2020
The roles of packing modes in manipulating gel stability and luminescence behavior in fluorescent supramolecular gels
Publisher: AIP Publishing
Date: 08-2022
DOI: 10.1063/5.0101373
Abstract: Fluorescent supramolecular gel is a large group in luminescent gels. In the scope of practical applications, excellent stability and robust luminescence are complementary and indispensable for high-performance fluorescent supramolecular gels. Therefore, in this Perspective, the proceedings of precursor explorations of stabilizing and boosting the luminescence behavior of the gels will be briefly summarized. The challenges and possible development frontiers will also be pondered to inspire future scientific research achievements.
Reversible and Continuous Color-Tunable Persistent Luminescence of Metal-Free Organic Materials by “Self”-Interface Energy Transfer
Publisher: American Chemical Society (ACS)
Date: 26-12-2019
Abstract: Persistent luminescence from metal-free organic materials is attractive for their ultralong exciton lifetimes. Color-tunable persistent luminescence from single-component organic materials is fascinating but still challenging. By utilizing an efficient approach of "self"-interface energy transfer (IET), the persistent luminescence color of an organic phosphor (CTXO) can be reversibly and continuously tuned by external physical stimuli. Its color circularly changes between green (lifetime = 0.24 s) and deep-yellow (lifetime = 0.10 s) when CTXO is repeatedly triggered with thermal annealing and mechanical grinding. Self-IET from the crystalline part (donor), which exhibits persistent room-temperature phosphorescence, to the amorphous part (acceptor) inside its semicrystal during these treatments is found to be the key exciton process for such novel color modulation. This also provides opportunity for designing stimuli-responsive smart materials with controlled persistent luminescence.
pH-Responsive Au(i )-disulfide nanoparticles with tunable aggregation-induced emission for monitoring intragastric acidity
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0SC01843K
Abstract: The water-stable and pH-responsive Au( i )-disulfide NPs serve as a luminescent probe for monitoring intragastric acidity in an acid-suppressed therapy.
Dual Behavior Regulation: Tether‐Free Deep‐Brain Stimulation by Photothermal and Upconversion Hybrid Nanoparticles
Publisher: Wiley
Date: 06-04-2023
Abstract: Optogenetics has been plagued by invasive brain implants and thermal effects during photo‐modulation. Here, two upconversion hybrid nanoparticles modified with photothermal agents, named PT‐UCNP‐B/G, which can modulate neuronal activities via photostimulation and thermo‐stimulation under near‐infrared laser irradiation at 980 nm and 808 nm, respectively, are demonstrated. PT‐UCNP‐B/G emits visible light (410–500 nm or 500–570 nm) through the upconversion process at 980 nm, while they exhibit efficient photothermal effect at 808 nm with no visible emission and tissue damage. Intriguingly, PT‐UCNP‐B significantly activates extracellular sodium currents in neuro2a cells expressing light‐gated channelrhodopsin‐2 (ChR2) ion channels under 980‐nm irradiation, and inhibits potassium currents in human embryonic kidney 293 cells expressing the voltage‐gated potassium channels (KCNQ1) under 808‐nm irradiation in vitro. Furthermore, deep‐brain bidirectional modulation of feeding behavior is achieved under tether‐free 980 or 808‐nm illumination (0.8 W cm −2 ) in mice stereotactically injected with PT‐UCNP‐B in the ChR2‐expressing lateral hypothalamus region. Thus, PT‐UCNP‐B/G creates new possibility of utilizing both light and heat to modulate neural activities and provides a viable strategy to overcome the limits of optogenetics.
AIE Bioconjugates for Biomedical Applications
Publisher: Wiley
Date: 28-05-2020
Visualization and quantification of cellular RNA production and degradation using a combined fluorescence and mass spectrometry characterization assay
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9CC03923F
Abstract: A combined fluorescence and mass spectrometry assay is developed to visualize and quantify cellular RNA production and degradation.
Aggregation-induced emission luminogen with excellent triplet–triplet upconversion efficiency for highly efficient non-doped blue organic light-emitting diodes
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1MH01129D
Abstract: Highly efficient non-doped blue TTU-OLEDs were realized based on the AIEgens with excellent emission and upconversion efficiency in the film states.
Drawing a clear mechanistic picture for the aggregation-induced emission process
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9QM00156E
Abstract: Excited-state “double-bond” torsion plays an important role in the nonluminescent behaviour of a stilbene-based twisted isomer.
A Simple and Sensitive Method for an Important Physical Parameter: Reliable Measurement of Glass Transition Temperature by AIEgens
Publisher: American Chemical Society (ACS)
Date: 27-09-2017
Anti-Kasha Triplet Energy Transfer: Excitation Wavelength Dependent Persistent Luminescence from Host-Guest Doping Systems
Publisher: Research Square Platform LLC
Date: 08-08-2023
DOI: 10.21203/RS.3.RS-3198725/V1
Abstract: Anti-Kasha’s emission in organic luminogens has attracted many attentions since its discovery. However, only limited ex les of anti-Kasha rule have been reported and anti-Kasha triplet energy transfer (ET) is even less-touched. This work provided an efficient strategy to realize excitation wavelength dependent (Ex-De) afterglow in a host-guest system benefiting from anti-Kasha rule. Host has almost imperceptible RTP upon 365 nm excitation and guest is totally RTP inactive, while the doping system exhibits Ex-De afterglow with improved quantum yields. Anti-Kasha triplet ET process is demonstrated from the higher excited triplet state T 2 of host to the lowest excited singlet state S 1 of the aggregated/unimolecular state of guest . ET efficiency in the doping system could be tuned by adopting denser or looser intermolecular packing through simply changing processing methods. The strategy of anti-Kasha triplet ET endows doping system with multiple stimuli-responsive properties, including Ex-De afterglow, mechano- and thermal-triggered afterglow behavior. Corresponding applications are also realized in multiple information anti-counterfeiting and display.
A highly efficient and AIE-active theranostic agent from natural herbs
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9QM00242A
Abstract: Berberine chloride, an AIE-active natural product, can be utilized as a highly efficient theranostic agent for cancer and bacteria.
Deciphering Structure–Functionality Relationship of Polycarbonate-Based Polyelectrolytes by AIE Technology
Publisher: American Chemical Society (ACS)
Date: 08-07-2020
Graphene Oxide Based Fluorescent DNA Aptasensor for Liver Cancer Diagnosis and Therapy
Publisher: Wiley
Date: 24-06-2021
Abstract: Graphene oxide (GO)‐based fluorescent DNA aptasensors are promising nanomaterials in bioassays owing to the fluorescent ultrasensitivity and target identification ability. However, their in vivo application remains an appealing yet significantly challenging task. In this contribution, for the first time, a nanomaterial for in vivo diagnosis and therapy of liver tumors is demonstrated. A DNA nanomaterial consisting of DNA tetrahedron and aptamers, aggregation‐induced emission luminogens, and antitumor drug doxorubicin, is fabricated and attached on the GO surface. This developed hybrid with good biocompatibility exhibits high selectivity to target liver cancer cells, and performs well in in vitro and in vivo liver tumor fluorescence imaging diagnosis and chemotherapy. Additionally, a GO‐based fluorescent DNA nanodevice is also constructed by using microfluidic chips for liver tumor cell screening.
Rational design of a water-soluble NIR AIEgen, and its application in ultrafast wash-free cellular imaging and photodynamic cancer cell ablation
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7SC04963C
Abstract: The first water-soluble NIR AIEgen was synthesized and used for ultrafast wash-free cellular imaging and photodynamic cancer cell ablation.
Visible‐ near infrared‐II skull optical clearing window for in vivo cortical vasculature imaging and targeted manipulation
Publisher: Wiley
Date: 10-07-2020
Fluorogenic Ag+ -Tetrazolate Aggregation Enables Efficient Fluorescent Biological Silver Staining
Publisher: Wiley
Date: 14-04-2018
Aggregation-induced emission polymers for high performance PLEDs with low efficiency roll-off
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0QM00012D
Abstract: AIE polymers pTPE-DPA-Cz and pTPE-DPA-Flu are synthesized and used as emitting layers in doped and non-doped polymeric LEDs through a solution process, and show maximum EQE of 3.26% in the doped PLEDs and CE of 3.69 cd A −1 for the non-doped PLEDs and low efficiency roll-off.
Near‐Infrared Aggregation‐Induced Emission Luminogens for In Vivo Theranostics of Alzheimer's Disease
Publisher: Wiley
Date: 02-12-2022
Abstract: Optimized theranostic strategies for Alzheimer's disease (AD) remain almost absent from bench to clinic. Current probes and drugs attempting to prevent β‐amyloid (Aβ) fibrosis encounter failures due to the blood–brain barrier (BBB) penetration challenge and blind intervention time window. Herein, we design a near‐infrared (NIR) aggregation‐induced emission (AIE) probe, DNTPH, via balanced hydrophobicity‐hydrophilicity strategy. DNTPH binds selectively to Aβ fibrils with a high signal‐to‐noise ratio. In vivo imaging revealed its excellent BBB permeability and long‐term tracking ability with high‐performance AD diagnosis. Remarkably, DNTPH exhibits a strong inhibitory effect on Aβ fibrosis and promotes fibril disassembly, thereby attenuating Aβ‐induced neurotoxicity. DNTPH treatment significantly reduced Aβ plaques and rescued learning deficits in AD mice. Thus, DNTPH serves as the first AIE in vivo theranostic agent for real‐time NIR imaging of Aβ plaques and AD therapy simultaneously.
Tetraphenylbenzosilole: An AIE Building Block for Deep-Blue Emitters with High Performance in Nondoped Spin-Coating OLEDs
Publisher: American Chemical Society (ACS)
Date: 12-11-2019
Abstract: 1,1,2,3,4,5-Hexaphenylsilole (HPS) is a star building block of aggregation-induced emission luminogens (AIEgens) in constructing OLED emitters. However, their development is obstructed by their complicated preparation and difficulty of achieving blue/deep-blue emission via structure modification and tuning. In this study, a benzo-group modification strategy was adopted to increase the skeleton rigidity and reduce the vibrational-rotational motion of peripheral substituted phenyl groups. The resulting building block, named tetraphenylbenzosilole (TPBS), was synthesized easily via a silyl radical cascade process with intermolecular radical cyclization. After the structure of the reaction substrate was tuned, four TPBS-based derivatives were obtained which not only inherited AIE characteristics from HPS but also exhibited high-efficiency deep-blue emission in the aggregated state thanks to their tuned HOMOs/LUMOs. Similar to HPS, propeller-like conformations in their single crystals were observed. In nondoped spin-coating OLEDs, these AIEgens all exhibited satisfactory performance with high EQEs (3.1-3.6%) at CIE coordinates of (0.15, 0.10), the best result reported so far for spin-coating-type AIEgens in blue nondoped OLEDs. All of the data showed the feasibility of our strategy for solving the shortage of AIEgens serving as building blocks for deep-blue emitters. We foresee the development of systems based on TPBS or its derivative materials inspired by this work.
Molecular Design and Biomedical Application of AIEgens with Photochemical Activity
Publisher: American Chemical Society (ACS)
Date: 19-05-2023
DOI: 10.1021/CBMI.3C00038
Highly efficient singlet oxygen generation, two-photon photodynamic therapy and melanoma ablation by rationally designed mitochondria-specific near-infrared AIEgens
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9SC06441A
Abstract: Mitochondria-targeted photosensitizers with highly efficient singlet oxygen generation, bright near-infrared AIE and good two-photon absorption are obtained through ingenious molecular engineering for cancer cell-selective photodynamic therapy.
Mitochondrial Imaging with Combined Fluorescence and Stimulated Raman Scattering Microscopy Using a Probe of the Aggregation-Induced Emission Characteristic
Publisher: American Chemical Society (ACS)
Date: 16-11-2017
DOI: 10.1021/JACS.7B06273
Abstract: In vivo quantitative measurement of biodistribution plays a critical role in the drug robe development and diagnosis/treatment process monitoring. In this work, we report a probe, named AIE-SRS-Mito, for imaging mitochondria in live cells via fluorescence (FL) and stimulated Raman scattering (SRS) imaging. The probe features an aggregation-induced emission (AIE) characteristic and possesses an enhanced alkyne Raman peak at 2223 cm
SwissKnife-Inspired Multifunctional Fluorescence Probes for Cellular Organelle Targeting Based on Simple AIEgens
Publisher: American Chemical Society (ACS)
Date: 28-12-2018
DOI: 10.1021/ACS.ANALCHEM.8B04736
Abstract: Facile, efficient, and mass production of aggregation-induced emission (AIE) luminogens (AIEgens) with excited-state intramolecular proton transfer (ESIPT) characteristics was achieved by a one-step condensation reaction of 2-(hydrazonomethyl)phenol with benzaldehydes. The function of as-prepared AIEgens could be tuned easily by varying the functional group being carried on the phenyl ring of benzaldehyde just like a Swiss knife handle. The suitable distance and angle of the intramolecular hydrogen bond in these AIEgens endowed them with ESIPT properties, intense solid-state luminescence, and large Stokes shifts (155-169 nm). These AIEgens could not only serve as biological probes showing specific targeting to lipid droplets, endoplasmic reticulum, and lysosomes, respectively, but also generate reactive oxygen species upon visible light irradiation to make them promise for photodynamic therapy.
Facile Access to Far‐Red Fluorescent Probes with Through‐Space Charge‐Transfer Effects for In Vivo Two‐Photon Microscopy of the Mouse Cerebrovascular System
Publisher: Wiley
Date: 31-08-2022
Abstract: Much effort has been devoted to the generation of fluorescent probes by synthetic approaches. In this study, we developed a facile strategy to construct far‐red fluorescent probes based on through‐space charge transfer within complexes of acceptors and donors and their “twist+twist” interactions. Owing to their rare two‐photon excitation property, the complexes could be used for in vivo imaging of the mouse cerebrovascular system.
Journey of Aggregation-Induced Emission Research
Publisher: American Chemical Society (ACS)
Date: 19-03-2018
Boric Acid‐Activated Room‐Temperature Phosphorescence and Thermally Activated Delayed Fluorescence for Efficient Solid‐State Photoluminescence Materials
Publisher: Wiley
Date: 25-06-2022
Abstract: The construction of highly luminescent solid‐state materials with long‐lived afterglow through a straightforward method is promising but still a challenging task. Herein, a heat‐treatment strategy is proposed to embed levofloxacin (Lev) in the matrix of boric acid (BA) to produce a complex with a photoluminescence quantum yield of 63.8% and an emission lifetime of 0.74 s (afterglow: s). Detailed investigations suggest that the unique photophysical properties of the complex are attributed to the confinement effect of BA matrix to Lev, which reduces the probability of nonradiative relaxation and activates the radiative decays to result in the promoted emission efficiency. In addition, thermally activated delayed fluorescence is also activated due to the alteration of the π transition of Lev by the formation of boron–carbon bonds. The emission color and lifetime are also modulated through controlling the synthetic conditions, which endow their applications both in light‐emitting diodes and information encryption. Thus, the present results are significant for the construction of solid‐state luminescent materials, including fluorescence and room‐temperature phosphorescence, and also provide a solid and universal theory to clarify their detailed emission profiles.
Donor/π‐Bridge Manipulation for Constructing a Stable NIR‐II Aggregation‐Induced Emission Luminogen with Balanced Phototheranostic Performance**
Publisher: Wiley
Date: 16-11-2021
Abstract: Owing to their versatile functionality and tunable energy dissipation, aggregation‐induced emission luminogens (AIEgens) have emerged as a potential platform for multimodal theranostics. Nevertheless, the construction of AIE‐active phototheranostic agents in the second near‐infrared window (NIR‐II, 1000–1700 nm), which allows superior resolution and minimized photodamage, is still a formidable challenge. Herein, benzo[ c ]thiophene serves as an electron‐rich and bulky donor (D)/π‐bridge, which can enlarge the conjugation length and distort the backbone of an AIEgen. By precise D/π‐bridge engineering, highly stable NIR‐II AIEgen DPBTA‐DPTQ nanoparticles are obtained with acceptable NIR‐II fluorescence quantum yield and excellent photothermal conversion efficiency. In addition, the spatial conformation of DPBTA‐DPTQ is determined for the first time by X‐ray single crystal diffraction and theoretical simulations. DPBTA‐DPTQ NPs have good biocompatibility and show efficient photothermal therapeutic effects in in vitro tests. Furthermore, DPBTA‐DPTQ NPs were used in fluorescence‐photoacoustic‐photothermal trimodal imaging‐guided photothermal eradication of tumors in HepG2 and B16‐F10 tumor‐xenografted mice.
Molecular Design, Circularly Polarized Luminescence, and Helical Self‐Assembly of Chiral Aggregation‐Induced Emission Molecules
Publisher: Wiley
Date: 07-01-2019
Abstract: Aggregation-induced emission luminogens (AIEgens) are a new class of luminophors, which are non-emissive in solution, but emit intensively upon aggregation. By properly designing the chemical structures of the AIEgens, their aggregation process can be tuned towards a desired direction to give erse novel luminescent architectures of micelles, rods, and helical fibers. AIEgens represent a kind of promising building block for the fabrication of luminescent micro/nanostructures with controllable morphologies. In this review, we describe our recent work in this research area, focusing on the molecular design, circularly polarized luminescence properties, and helical self-assembly behavior of AIEgens.
Aggregation-Induced Emission-Active Biomacromolecules: Progress, Challenges, and Opportunities
Publisher: American Chemical Society (ACS)
Date: 16-02-2022
DOI: 10.1021/ACS.BIOMAC.1C01516
Abstract: Biomacromolecules featuring aggregation-induced-emission (AIE) characteristics generally present new properties and performances that are silent in the molecular state, providing endless possibilities for the evolution of biomedical applications. Tremendous achievements based on the research of AIE-active biomacromolecules have been made in synthetic exploration, material development, and practical applications. In this Perspective, we give a brief account in the development of AIE-active biomacromolecules. Remarkable progresses have been made in the exploration of AIE-active biomacromolecule preparation, structure-property relationships, and the relevant biomedical applications. The existing challenges and promising opportunities, as well as the future directions in AIE-active biomacromolecule research, are also discussed. It is expected that this Perspective can act as a trigger for the innovation of AIE-active biomacromolecule research and aggregate science.
Recent advances in aggregation-induced emission materials for enhancing solar energy utilization
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D2NH00506A
Abstract: We summarized the recent progress of aggregation-induced emission (AIE) materials in luminescent solar concentrators, photosynthesis augmentation and solar steam generation. The luminescence and heat generation of AIE materials in different states have been utilized.
Biomimetic Glucan Particles with Aggregation-Induced Emission Characteristics for Noninvasive Monitoring of Transplant Immune Response
Publisher: American Chemical Society (ACS)
Date: 15-07-2021
Abstract: Real-time monitoring of post-transplant immune response is critical to prolong the survival of grafts. The current gold standard for assessing the immune response to graft is biopsy. However, such a method is invasive and prone to false negative results due to limited tissue size available and the heterogeneity of the rejection site. Herein, we report biomimetic glucan particles with aggregation-induced emission (AIE) characteristics (HBTTPEP/GPs) for real-time noninvasive monitoring of post-transplant immune response. We have found that the positively charged near-infrared AIEgens can effectively aggregate in the confined space of glucan particles (GPs), thereby turning on the fluorescence emission. HBTTPEP/GPs can track macrophages for 7 days without h ering the bioactivity. Oral administration of HBTTPEP/GPs can specially target macrophages by mimicking yeast, which then migrate to the transplant rejection site. The fluorescence emitted from HBTTPEP/GPs correlated well with the infiltration of macrophages and the degree of allograft rejection. Furthermore, a single oral HBTTPEP/GPs dose can dynamically evaluate the therapeutic response to immunosuppressive therapy. Consequently, the biomimetic AIE-active glucan particles can be developed as a promising probe for immune-monitoring in solid organ transplantation.
A Class of Biocompatible Dye–Protein Complex Optical Nanoprobes
Publisher: American Chemical Society (ACS)
Date: 23-12-2021
Abstract: Molecular organic dyes are classic fluorescent nanoprobes finding tremendous uses in biological and life sciences. Yet, they suffer from low brightness, poor photostability, and lack of functional groups for bioconjugation. Here, we describe a class of biocompatible dye-protein optical nanoprobes, which show long-time photostability, superbrightness, and enriched functional groups. These nanoprobes utilize apoferritin (an intracellular protein for iron stores and release) to encase appropriate molecular organic dyes to produce on-demand fluorescence in aqueous solution. A pH-driven dissociation-reconstitution process of apoferritin subunits allows substantial incorporation of hydrophilic (aggregation caused quenching, ACQ) or hydrophobic (aggregation induced enhancement, AIE) dye molecules into the protein nanocavity (8 nm), producing monodispersed dye-apoferritin nanoparticles (apo-dye-NPs, ∼12 nm). As compared with single dye monomer, single apo-dye-NPs possess hundreds of times larger molar extinction coefficient and 2 orders of magnitude higher absolute luminescence quantum yield (up to 45-fold), multiplying fluorescence brightness up to 2778-fold. We show that varying the type of incorporated dyes entails a precise control over nanoprobe emission profile tunable in a broad spectral range of 370-1300 nm. Mechanical investigations indicate that the ersified microstructures of nanocavity inner surface are able to conform ACQ dyes at reasonable space interval while providing protein-guided-stacking for AIE dyes, thus enhancing fluorescence quantum yield through confining intermolecular quenching and intramolecular rotation. Moreover, apo-dye-NPs are able to emit stable fluorescence (over 13 min) without quenching in confocal imaging of HepG2 cancer cell under ultrahigh laser irradiance (1.3 × 10 6 W/cm 2 ). These superb properties make them suitable, as demonstrated in this work, for long-term super-resolved structured illumination microscopic cell imaging (spatial resolution, 117 nm) over 48 h, near-infrared (NIR) fluorescence angiography imaging of whole-body blood vessels (spatial resolution, 380 μm), and NIR photoacoustic imaging of liver in vivo .
Recent advances in luminescent materials for super-resolution imaging via stimulated emission depletion nanoscopy
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0CS00676A
Abstract: Recent progress on STED fluorophores for super-resolution imaging and also their characteristics are outlined here, thus providing some guidelines to select proper probes and even develop new materials for super-resolution imaging via STED nanoscopy.
Ionofluorochromic Nanoparticles Derived from Octapyrene-Modified Polyhedral Oligomeric Silsesquioxane Organic Frameworks for Fluoride-Ion Detection
Publisher: American Chemical Society (ACS)
Date: 20-12-2018
Ultralong UV/mechano-excited room temperature phosphorescence from purely organic cluster excitons
Publisher: Springer Science and Business Media LLC
Date: 14-11-2019
DOI: 10.1038/S41467-019-13048-X
Abstract: Purely organic room temperature phosphorescence (RTP) has attracted wide attention recently due to its various application potentials. However, ultralong RTP (URTP) with high efficiency is still rarely achieved. Herein, by dissolving 1,8-naphthalic anhydride in certain organic solid hosts, URTP with a lifetime of over 600 ms and overall quantum yield of over 20% is realized. Meanwhile, the URTP can also be achieved by mechanical excitation when the host is mechanoluminescent. Femtosecond transient absorption studies reveal that intersystem crossing of the host is accelerated substantially in the presence of a trace amount of 1,8-naphthalic anhydride. Accordingly, we propose that a cluster exciton spanning the host and guest forms as a transient state before the guest acts as an energy trap for the RTP state. The cluster exciton model proposed here is expected to help expand the varieties of purely organic URTP materials based on an advanced understanding of guest/host combinations.
Incorporation of Planar Blocks into Twisted Skeletons: Boosting Brightness of Fluorophores for Bioimaging beyond 1500 Nanometer
Publisher: American Chemical Society (ACS)
Date: 10-2020
Polymerization of 1-chloro-2-phenylacetylene derivatives by using a Brookhart-type catalyst
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9PY00974D
Abstract: A Brookhart-type catalyst (α-diimine)PdMeCl/AgOTf works well in the polymerization of 1-chloro-2-phenylacetylene monomers bearing nonpolar olar and electron releasing/withdrawing substituents in nonpolar olar solvents.
As Fiber Meets with AIE: Opening a Wonderland for Smart Flexible Materials
Publisher: Wiley
Date: 21-12-2023
Abstract: Aggregation‐induced emission luminogens (AIEgens) have recently been developed at a tremendous pace in the area of organic luminescent materials by virtue of their superior properties. However, the practical applications of AIEgens still face the challenge of transforming AIEgens from molecules into materials. Till now, many AIEgens have been integrated into fiber, endowing the fiber with prominent fluorescence and/or photosensitizing capacities. AIEgens and fiber complement each other for making progress in flexible smart materials, in which the utilization of AIEgens creates new application possibilities for fiber, and the fiber provides an excellent carrier for AIEgens towards realizing the conversion from molecule to materials and an ideal platform to research the aggregate state of AIEgens in mesoscale and macroscale. This review begins with a brief summary of the recent advances related to some typical AIEgens with various functions and the technology for the fabrication of AIEgen‐functionalized fiber. The most representative applications are then highlighted by focusing on energy conversion, personal protective equipment, biomedical, sensor, and fluorescence‐related fields. Finally, the challenges, opportunities, and tendencies in future development are discussed in detail. This review hopes to inspire innovation in AIEgens and fiber from the view of mesoscale and macroscale.
Room Temperature Multicomponent Polymerizations of Alkynes, Sulfonyl Azides, and Iminophosphorane toward Heteroatom-Rich Multifunctional Poly(phosphorus amidine)s
Publisher: American Chemical Society (ACS)
Date: 11-08-2017
Phosphazene Base-Mediated Azide–Alkyne Click Polymerization toward 1,5-Regioregular Polytriazoles
Publisher: American Chemical Society (ACS)
Date: 13-06-2019
Novel Quinolizine AIE System: Visualization of Molecular Motion and Elaborate Tailoring for Biological Application**
Publisher: Wiley
Date: 24-01-2022
Abstract: Molecular motions are ubiquitous in nature and they immutably play intrinsic roles in all actions. However, exploring appropriate models to decipher molecular motions is an extremely important but very challenging task for researchers. Considering aggregation‐induced emission (AIE) luminogens possess their unique merits to visualize molecular motions, it is particularly fascinating to construct new AIE systems as models to study molecular motion. Herein, a novel quinolizine (QLZ) AIE system was constructed based on the restriction intramolecular vibration (RIV) mechanism. It was demonstrated that QLZ could act as an ideal model to visualize single‐molecule motion and macroscopic molecular motion via fluorescence change. Additionally, further elaborate tailoring of this impressive core achieved highly efficient reactive oxygen species production and realized fluorescence imaging‐guided photodynamic therapy applications, which confirms the great application potential of this new AIE‐active QLZ core. Therefore, this work not only provides an ideal model to visualize molecular motion but also opens a new way for the application of AIEgens.
Molecular Motion and Nonradiative Decay: Towards Efficient Photothermal and Photoacoustic Systems
Publisher: Wiley
Date: 21-06-2022
Abstract: Nonradiative decay invariably competes with radiative decay during the deexcitation process of matter. In the community of luminescence research, nonradiative decay has been deemed less attractive than radiative decay. However, all things in their being are good for something and so is nonradiative decay. As the molecular motion‐facilitated nonradiative decay (MMFND) effect is inevitable in photophysical processes, it provides a new avenue to convert the harvested light energy into exploitable forms by harnessing molecular motion. In many cases, active molecular motion enables thermal deactivation from excited states. In this Minireview, recent advances in photothermal and photoacoustic systems with MMFND character are summarized. We believe that this presentation of the rational engineering of molecular motion for efficient photothermal generation will deepen the understanding of the relationship between molecular motion and nonradiative decay and navigate people to rethink the positive aspects of nonradiative decay for the establishment of new light‐controllable techniques.
AIEgen-based theranostic system: targeted imaging of cancer cells and adjuvant amplification of antitumor efficacy of paclitaxel
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6SC03859J
Abstract: An AIEgen-based theranostic system is developed to lify the antitumor efficacy of paclitaxel with a synergistic effect of “0 + 1 1”.
Strategies to Enhance the Photosensitization: Polymerization and the Donor–Acceptor Even–Odd Effect
Publisher: Wiley
Date: 22-10-2018
Abstract: A particular challenge in the design of organic photosensitizers (PSs) with donor-acceptor (D-A) structures is that it is based on trial and error rather than specific rules. Now these challenges are addressed by proposing two efficient strategies to enhance the photosensitization efficiency: polymerization-facilitated photosensitization and the D-A even-odd effect. Conjugated polymers have been found to exhibit a higher
The One‐Stop Integrated Nanoagent Based on Photothermal Therapy for Deep Infection Healing and Inflammation Inhibition
Publisher: Wiley
Date: 19-10-2023
White light emission from a single organic molecule with dual phosphorescence at room temperature
Publisher: Springer Science and Business Media LLC
Date: 04-09-2017
DOI: 10.1038/S41467-017-00362-5
Abstract: The development of single molecule white light emitters is extremely challenging for pure phosphorescent metal-free system at room temperature. Here we report a single pure organic phosphor, namely 4-chlorobenzoyldibenzothiophene, emitting white room temperature phosphorescence with Commission Internationale de l’Éclair-age coordinates of (0.33, 0.35). Experimental and theoretical investigations reveal that the white light emission is emerged from dual phosphorescence, which emit from the first and second excited triplet states. We also demonstrate the validity of the strategy to achieve metal-free pure phosphorescent single molecule white light emitters by intrasystem mixing dual room temperature phosphorescence arising from the low- and high-lying triplet states.
Tailoring the Amphiphilic Structure of Zwitterionic AIE Photosensitizers to Boost Antitumor Immunity
Publisher: Wiley
Date: 27-07-2023
Abstract: Although photodynamic therapy (PDT) for thorough cancer treatment is hindered by the limited generation of reactive oxygen species (ROS) with short lifetime from photosensitizers, PDT‐induced antitumor immune response remedies the defects. Previous studies show that inducing immunogenic cell deaths is an attractive approach to activate antitumor immunity, which confers a robust adjuvanticity to dying cancer cells. In this work, hiphilic luminogens with aggregation‐induced emission characteristics (AIEgens) are rationally designed and synthesized. By modulating the hydrophobic π ‐bridge and zwitterionic functional groups, these AIEgens exhibit tunable organelle specificity to lysosome, endoplasmic reticulum, and plasma membrane and enhance ROS generation ability. Notably, the membrane‐targeting AIEgen namely TPS‐2 induces cell death and membrane rupture via PDT to facilitate the release of antigens and activation of immune cells. Furthermore, the size‐controlled TPS‐2 nanoaggregates are found to serve as an adjuvant, promoting antigen accumulation and delivery to sufficiently boost the in vivo antitumor immunity by only one dose injection in a prophylactic tumor vaccination model. This work thus provides new insights into optimizing AIE photosensitizers via a hydrophobicity–hydrophilicity balance strategy for evoking an antitumor immunity and directly suppressing the distanced tumor. A single small‐molecular system for PDT‐stimulated antitumor immunity is envisioned.
Self-Reporting and Photothermally Enhanced Rapid Bacterial Killing on a Laser-Induced Graphene Mask
Publisher: American Chemical Society (ACS)
Date: 11-08-2020
Platinum-AIEgen coordination complex for imaging-guided annihilation of cisplatin-resistant cancer cells
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0CC00821D
Abstract: A new platinum-AIEgen coordination complex was synthesized, enabling efficient imaging-guided annihilation of cisplatin-resistant cancer cells under mild white light irradiation.
Manipulation of Molecular Aggregation States to Realize Polymorphism, AIE, MCL, and TADF in a Single Molecule
Publisher: Wiley
Date: 23-08-2018
Evoking Highly Immunogenic Ferroptosis Aided by Intramolecular Motion‐Induced Photo‐Hyperthermia for Cancer Therapy
Publisher: Wiley
Date: 08-02-2022
Abstract: Immunogenic cell death (ICD) through apoptosis or necroptosis is widely adopted to improve the therapeutic effect in cancer treatment by triggering a specific antitumor immunity. However, the tumor resistance to apoptosis/necroptosis seriously impedes the therapeutic effect. Recently, ferroptosis featured with excessive lipid peroxidation is demonstrated capable of bypassing the apoptosis/necroptosis resistance to kill cancer cells. To date, numerous efficient ferroptosis inducers are developed and successfully utilized for sensitizing cancer cells to ferroptosis. Unfortunately, these inducers can hardly generate adequate immunogenicity during induction of ferroptotic cancer cell death, which distinctly attenuates the efficacy of triggering antitumor immune response, therefore leads to unsatisfactory therapeutic effect. Herein, a novel high‐performance photothermal nanoparticle (TPA‐NDTA NP) is designed by exploiting energy via excited‐state intramolecular motion and employed for immensely assisting ferroptosis inducer to evoke highly efficient ICD through ferroptosis pathway. Tumor models with poor immunogenicity are used to demonstrate the tremendously enhanced therapeutic effect endowed by highly enhanced immunogenic ferroptosis in vitro and in vivo by virtue of the NPs. This study sheds new light on a previously unrecognized facet of boosting the immunogenicity of ferroptosis for achieving satisfactory therapeutic effect in cancer therapy.
A Facile Structural Isomerization‐Induced 3D Spatial D‐A Interlocked Network for Achieving NIR‐II Phototheranostic Agents
Publisher: Wiley
Date: 15-11-2022
Abstract: The performances of second near‐infrared (NIR‐II) organic phototheranostic agents (OPTAs) depend on both molecular structure and molecular packing when used as nanoparticles (NPs). Herein, we proposed a facile structural isomerization‐induced 3D spatial donor (D)‐acceptor (A) interlocked network for achieving NIR‐II OPTAs. Two isomers, 4MNVDPP and 6MNVDPP were synthesized and formulated into NPs. 6MNVDPP, which has a larger electrostatic potential difference, exhibits a compact 3D spatial D‐A interlocked network in the crystal form, while 4MNVDPP forms 2D D‐D type J ‐aggregates. Thus, 6MNVDPP NPs show red‐shifted NIR absorption and larger molar extinction coefficient than 4MNVDPP NPs. Thanks to the typical NIR‐II emission, superior photothermal‐stability, high photothermal conversion efficiency (89 %) and reactive oxygen species production capacity, 6MNVDPP NPs exhibit outstanding NIR‐II tiny capillary vasculature/tumor imaging ability and synergistic photothermal hotodynamic anti‐cancer effect in vivo.
Development of Sulfonamide‐Functionalized Charge‐Reversal AIE Photosensitizers for Precise Photodynamic Therapy in the Acidic Tumor Microenvironment
Publisher: Wiley
Date: 05-2023
Abstract: Tumor‐targeted photodynamic therapy (PDT) is desirable as it can achieve efficient killing of tumor cells with no or less harm to normal cells. Herein, a facile molecular engineering strategy is developed for photosensitizers (PSs) with aggregation induced emission (AIE) characteristics and responsive properties to the acidic tumor microenvironment (TME). By the marriage of pH‐sensitive sulfonamide moieties with AIE PSs, two near‐infrared AIE luminogens called DBP‐SPy and DBP‐SPh are designed and synthesized. Both luminogens can form negatively charged nanoaggregates in the aqueous medium at physiological pH. The DBP‐SPy nanoaggregates undergo surface charge conversion to become positive at pH close to the signature pH of TME, while DBP‐SPh nanoaggregates show no such property. The endowed response to acidic TME enables the enhanced cellular uptake of DBP‐SPy at pH = 6.8. By contrast, its cellular uptake is much sacrificed at pH 7.4. As a result, under white light irradiation, DBP‐SPy nanoaggregates demonstrate a considerable photodynamic therapeutic effect on cancer cells in vitro and excellent tumor growth inhibition in vivo. Hence, this study not only provides an acidic TME‐responsive AIE PS for precise PDT, but also inspires new design strategies for AIE‐based theragnostic systems with targeting characteristics.
A Water‐Stable and Red‐Emissive Radical Cation for Mutp53 Cancer Therapy
Publisher: Wiley
Date: 17-10-2022
Abstract: Compared with conventional closed‐shell fluorophores, radical cations provide an opportunity for development of red‐to‐NIR fluorophores with small sizes and easy preparation. However, most radical cations reported in the literature suffer from poor stability in water solution and are almost non‐emissive. To tackle this challenge, we herein develop a deep‐red‐emissive and water‐stable pyrrole radical cation P⋅ + −DPA−Zn, which can be easily generated from P−DPA−Zn by air oxidation. The deep‐red‐emissive P⋅ + −DPA−Zn can be used for imaging‐guided mitochondria‐targeted delivery of Zn 2+ into cancer cells to promote mutant p53 proteins degradation and abrogate mutp53‐manifested gain of function, including reduced chemotherapy resistance, inhibited cancer cell migration, decreased tumor cell colony and sphere formation. The water‐stable and deep‐red emissive pyrrole radical cation is thus promising for cancer theranostic applications.
Stereoisomeric engineering of aggregation-induced emission photosensitizers towards fungal killing
Publisher: Springer Science and Business Media LLC
Date: 17-11-2022
DOI: 10.1038/S41467-022-34358-7
Abstract: Fungal infection poses and increased risk to human health. Photodynamic therapy (PDT) as an alternative antifungal approach garners much interest due to its minimal side effects and negligible antifungal drug resistance. Herein, we develop stereoisomeric photosensitizers (( Z )- and ( E )-TPE-EPy) by harnessing different spatial configurations of one molecule. They possess aggregation-induced emission characteristics and ROS, viz . 1 O 2 and O 2 −• generation capabilities that enable image-guided PDT. Also, the cationization of the photosensitizers realizes the targeting of fungal mitochondria for antifungal PDT killing. Particularly, stereoisomeric engineering assisted by supramolecular assembly leads to enhanced fluorescence intensity and ROS generation efficiency of the stereoisomers due to the excited state energy flow from nonradiative decay to the fluorescence pathway and intersystem (ISC) process. As a result, the supramolecular assemblies based on ( Z )- and ( E )-TPE-EPy show dramatically lowered dark toxicity without sacrificing their significant phototoxicity in the photodynamic antifungal experiments. This study is a demonstration of stereoisomeric engineering of aggregation-induced emission photosensitizers based on ( Z )- and ( E )-configurations.
Spontaneous and Fast Molecular Motion at Room Temperature in the Solid State
Publisher: Wiley
Date: 28-02-2019
3D-Printed, Portable, Fluorescent-Sensing Platform for Smartphone-Capable Detection of Organophosphorus Residue Using Reaction-Based Aggregation Induced Emission Luminogens
Publisher: American Chemical Society (ACS)
Date: 18-08-2021
Structure design and performance of photomultiplication-type organic photodetectors based on an aggregation-induced emission material
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9NR09386A
Abstract: High performance photomultiplication-type organic photodetectors based on an AIE material were successfully fabricated by designing a device structure.
Real-time monitoring of hydrophobic aggregation reveals a critical role of cooperativity in hydrophobic effect
Publisher: Springer Science and Business Media LLC
Date: 31-05-2017
DOI: 10.1038/NCOMMS15639
Abstract: The hydrophobic interaction drives nonpolar solutes to aggregate in aqueous solution, and hence plays a critical role in many fundamental processes in nature. An important property intrinsic to hydrophobic interaction is its cooperative nature, which is originated from the collective motions of water hydrogen bond networks surrounding hydrophobic solutes. This property is widely believed to enhance the formation of hydrophobic core in proteins. However, cooperativity in hydrophobic interactions has not been successfully characterized by experiments. Here, we quantify cooperativity in hydrophobic interactions by real-time monitoring the aggregation of hydrophobic solute (hexaphenylsilole, HPS) in a microfluidic mixer. We show that association of a HPS molecule to its aggregate in water occurs at sub-microsecond, and the free energy change is −5.8 to −13.6 kcal mol −1 . Most strikingly, we discover that cooperativity constitutes up to 40% of this free energy. Our results provide quantitative evidence for the critical role of cooperativity in hydrophobic interactions.
Augmenting photosynthesis through facile AIEgen-chloroplast conjugation and efficient solar energy utilization
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1MH00012H
Abstract: Two new AIE molecules with activated alkyne groups were successfully conjugated with live chloroplasts by a facile metal-free “Click” reaction, and the formed artificial AIEgen-chloroplast owned the increased photosynthetic activity.
Highly Stable and Bright NIR-II AIE Dots for Intraoperative Identification of Ureter
Publisher: American Chemical Society (ACS)
Date: 23-01-2020
Abstract: Iatrogenic ureteral injury is a dreaded complication of abdominal and pelvic surgeries, and thus, intraoperative identification of ureters is of paramount importance but lacks efficient methods and probes. Herein, we used near-infrared II (NIR-II, 1000-1700 nm) fluorescence imaging with advantages of higher spatial resolution, deeper tissue penetration, lower light scattering, and less tissue autofluorescence to identify ureters by aggregation-induced emission luminogen dots (AIE dots). The intraoperative ureteral injuries and common ureteral diseases can be visualized timely and precisely. Due to the longer emission wavelength and higher quantum yield of the AIE dots, it largely outperforms the commercial indocyanine green dye in brightness and penetration depth. It was the first time to realize the intraoperative identification of ureters in vivo using NIR-II imaging. Thus, our work provides a new platform for intraoperative monitoring during clinical operation.
AIE-Active Antibiotic Photosensitizer with Enhanced Fluorescence in Bacteria Infected Cells and Better Therapy Effect toward Drug-Resistant Bacteria
Publisher: American Chemical Society (ACS)
Date: 16-09-2022
Insight into the strong aggregation-induced emission of low-conjugated racemic C6-unsubstituted tetrahydropyrimidines through crystal-structure–property relationship of polymorphs
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5SC01226K
Abstract: Racemic low-conjugated non-emissive THPs 1–3 can form highly emissive RS - and RR / SS -packing polymorphs with mixed through-bond and through-space conjugation.
Two Cholesterol-Containing Pyrene Derivatives: Subtle Spacer Difference, Diverse Stimuli-Responsive Luminescence, Chirality, and Self-Assembly Behaviors
Publisher: American Chemical Society (ACS)
Date: 14-09-2022
Abstract: Two chiral molecules
A Substitution‐Dependent Light‐Up Fluorescence Probe for Selectively Detecting Fe3+ Ions and Its Cell Imaging Application
Publisher: Wiley
Date: 08-07-2018
Recent Advances in Aggregation‐Induced Emission Materials and Their Biomedical and Healthcare Applications
Publisher: Wiley
Date: 21-08-2021
Abstract: The emergence of the concept of aggregation‐induced emission (AIE) has opened new opportunities in many research areas, such as biopsy analysis, biological processes monitoring, and elucidation of key physiological and pathological behaviors. As a new class of luminescent materials, AIE luminogens (AIEgens) possess many prominent advantages such as tunable molecular structures, high molar absorptivity, high brightness, large Stokes shift, excellent photostability, and good biocompatibility. The past two decades have witnessed a dramatic growth of research interest in AIE, and many AIE‐based bioprobes with excellent performance have been widely explored in biomedical fields. This review summarizes some of the latest advancements of AIE molecular probes and AIE nanoparticles (NPs) with regards to biomedical and healthcare applications. According to the research areas, the review is ided into five sections, which are imaging and identification of cells and bacteria, photodynamic therapy, multimodal theranostics, deep tissue imaging, and fluorescence‐guided surgery. The challenges and future opportunities of AIE materials in the advanced biomedical fields are briefly discussed. In perspective, the AIE‐based bioprobes play vital roles in the exploration of advanced bioapplications for the ultimate goal of addressing more healthcare issues by integrating various cutting‐edge modalities and techniques.
Circularly Polarized Luminescence and Tunable Helical Assemblies of Aggregation-Induced Emission Amphiphilic Polytriazole Carrying Chiral l -Phenylalanine Pendants
Publisher: American Chemical Society (ACS)
Date: 27-07-2020
Hydrogel-derived luminescent scaffolds for biomedical applications
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0QM01140A
Abstract: We provide a review on how luminescence functionality can be integrated with modifiable hydrogels to extend the frontiers of luminescent materials for health technologies.
Enantiomeric Switching of the Circularly Polarized Luminescence Processes in a Hierarchical Biomimetic System by Film Tilting
Publisher: American Chemical Society (ACS)
Date: 04-12-2020
Delicate modulation of triplet energy levels for activating “hot excitons” channels in deep red AIEgens
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0TC03813J
Abstract: A delicate modulation of triplet excited-state energy levels in deep-red AIEgens is reported for designing “hot exciton”-type OLED emitters with high performance.
A Dihydroazulene‐Based Photofluorochromic AIE System for Rewritable 4D Information Encryption
Publisher: Wiley
Date: 03-08-2022
Abstract: Dynamic patterns based on luminescent materials play an essential role in the digital age. However, it is still challenging to develop highly emissive photofluorochromic materials with dynamic behaviors to store information with multiple characteristics. Here, we report a series of dihydroazulene‐based compounds which show typical aggregation‐induced emission (AIE) effect. Moreover, the photo‐switching ability of the dihydroazulene units, undergoing light‐induced ring‐opening, enables photofluorochromic properties. The photofluorochromism also shows quantitively described responses to time and temperature via a reverse ring‐closing process. Ultimately, a rewritable 4D information system, embedded with a quick response code, dot matrix with microstructures, color matrix of fluorescence, and time/temperature‐dependent intensity change, is established with dynamic patterns. This work not only develops a dynamic AIE skeleton with photofluorochromic properties but also provides a new strategy for information encryption and cybernetics.
A Universal Boronate‐Affinity Crosslinking‐Amplified Dynamic Light Scattering Immunoassay for Point‐of‐Care Glycoprotein Detection
Publisher: Wiley
Date: 23-12-2022
Abstract: Herein, we report a universal boronate‐affinity crosslinking‐ lified dynamic light scattering (DLS) immunoassay for point‐of‐care (POC) glycoprotein detection in complex s les. This enhanced DLS immunoassay consists of two elements, i.e., antibody‐coated magnetic nanoparticles (MNP@mAb) for target capture and DLS signal transduction, and phenylboronic acid‐based boronate‐affinity materials as crosslinking lifiers. Upon the addition of targets, glycoproteins are first captured by MNP@mAb and lified by target‐induced crosslinking stemming from the selective binding between the boronic acid ligand and cis ‐diol‐containing glycoprotein, thereby resulting in a remarkably increased DLS signal in the average nanoparticle size. Benefiting from the multivalent binding and fast boronate‐affinity reaction between glycoproteins and crosslinkers, the proposed immunosensing strategy has achieved the ultrasensitive and rapid quantitative assay of glycoproteins at the fM level within 15 min. Overall, this work provides a promising and versatile design strategy for extending the DLS technique to detect glycoproteins even in the field or at POC.
Synthesis of Functional Poly(propargyl imine)s by Multicomponent Polymerizations of Bromoarenes, Isonitriles, and Alkynes
Publisher: American Chemical Society (ACS)
Date: 22-11-2017
Direct Conversion from Carbon Dioxide to Luminescent Poly(β-alkoxyacrylate)s via Multicomponent Tandem Polymerization-Induced Emission
Publisher: American Chemical Society (ACS)
Date: 18-08-2021
Multiring-induced multicolour emission: hyperbranched polysiloxane with silicon bridge for data encryption
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0QM00075B
Abstract: The presented work shows an impressive multicolour luminescence hyperbranched polysiloxane attributed to the multiring through-space conjugation named “multiring induced multicolor emission” (MIE), as well as its application in data encryption.
Recent advances of AIE light-up probes for photodynamic therapy
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1SC00045D
Abstract: AIE fluorogens provide new opportunities for the development of light-up probes for photodynamic therapy.
Phenol‐yne Click Polymerization: An Efficient Technique to Facilely Access Regio‐ and Stereoregular Poly(vinylene ether ketone)s
Publisher: Wiley
Date: 27-07-2017
Abstract: Alkyne-based click polymerizations have been well-established. However, in order to expand the family to synthesize polymers with new structures and novel properties, new types of click polymerizations are highly demanded. In this study, for the first time, we established a new efficient and powerful phenol-yne click polymerization. The activated diynes and diphenols could be facilely polymerized in the presence of the Lewis base catalyst of 4-dimethylaminopyridine (DMAP) under mild reaction conditions. Regio- and stereoregular poly(vinylene ether ketone)s (PVEKs) with high molecular weights (up to 35 200) were obtained in excellent yields (up to 99.0 %). The reaction mechanism was well explained under the assistance of density functional theory (DFT) calculation. Furthermore, since the vinyl ether sequence acts as a stable but acid-liable linkage, the polymers could be decomposed under acid conditions, rendering them applicable in biomedical and environmental fields.
Aggregation‐Induced Emission: New Vistas at the Aggregate Level
Publisher: Wiley
Date: 14-05-2020
Unusual Through‐Space Interactions between Oxygen Atoms that Mediate Inverse Morphochromism of an AIE Luminogen
Publisher: Wiley
Date: 20-11-2019
Abstract: We have studied the photophysics of tetrafurylethene, an aggregation‐induced emission luminogen with exceptionally short intramolecular O−O distances of 2.80 Å and a significant red‐shifted morphochromism (27 nm) when going from the aggregate to the crystal. The short O−O distances, which are substantially smaller than the sum of the van der Waals radii (3.04 Å), are due to the fact that the oxygen atoms act as an electronic bridge connecting the furan rings on opposite ends of the central double bond, giving rise to a circular delocalization of the π‐electron density across the rings. In the excited state the O−O distance is further reduced to 2.70 Å the increased O−O interaction causes a narrowing of the HOMO–LUMO gap, resulting in the red morphochromism of the emission. Our results show the structural origin of the red‐shifted emission lies in close O−O contacts, paving the way for understanding the clusteroluminescence of oxygen‐rich non‐conjugated systems that emit visible light.
Organic Dots with Large π-Conjugated Planar for Cholangiography beyond 1500 nm in Rabbits: A Non-Radioactive Strategy
Publisher: American Chemical Society (ACS)
Date: 12-03-2021
Water‐Soluble Aggregation‐Induced Emission Luminogens with Near‐Infrared Emission for Advanced Phototheranostics
Publisher: Wiley
Date: 21-07-2023
Abstract: The development of water‐soluble aggregation‐induced emission luminogens (AIEgens) emitting in the near‐infrared (NIR) window holds promise for efficient biomedical applications. Nevertheless, synthesizing water‐soluble counterparts of NIR AIEgens presents difficulties due to their intrinsic hydrophobic properties. To address this issue, researchers have developed various molecular design strategies to improve the water solubility of NIR AIEgens. The integration of hydrophilic groups and targeting moieties is a crucial aspect of achieving precise phototheranostics. Here, erse approaches to attain water‐soluble NIR AIEgens for biomedical applications are presented, and three commonly used strategies that involve decorating NIR AIEgens with positively or negatively charged groups, hydrophilic chains, and bioactive moieties are elaborated. These rational design strategies are believed to provide solutions for enhancing the water solubility and biological performance of NIR AIEgens in a single action. The remaining challenges and opportunities in this field are also discussed. The aim is to provide new insights into the design of water‐soluble NIR AIEgens and inspire more researchers to make significant contributions to this promising research area.
Organic solid fluorophores regulated by subtle structure modification: color-tunable and aggregation-induced emission
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6SC02875F
Abstract: Organic solid fluorophores based on p -bis(2,2-dicyanovinyl)benzene were designed and synthesized, which displayed a tunable emission color and substituent dependent optical behavior.
Multifunctional AIEgens: Ready Synthesis, Tunable Emission, Mechanochromism, Mitochondrial, and Bacterial Imaging
Publisher: Wiley
Date: 09-11-2017
One-step light-up metabolic probes for in situ discrimination and killing of intracellular bacteria
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1QM01495A
Abstract: TPEPy-Ala and TPAPy-Kdo with metabolic moieties can be directly incorporated into the bacterial cell envelopes and light up intracellular bacteria. Additionally, the metabolic probes can effectively eliminate labeled bacteria in situ with minimal host cell cytotoxicity via photodyanmic therapy.
Aggregation-Induced Emission Luminogens for Cell Death Research
Publisher: American Chemical Society (ACS)
Date: 24-02-2022
A Multiresponsive Functional AIEgen for Spatiotemporal Pattern Control and All‐round Information Encryption
Publisher: Wiley
Date: 22-03-2023
Abstract: Functional materials with multi‐responsive properties and good controllability are highly desired for developing bioinspired and intelligent multifunctional systems. Although some chromic molecules have been developed, it is still challenging to realize in situ multicolor fluorescence changes based on a single luminogen. Herein, we reported an aggregation‐induced emission (AIE) luminogen called CPVCM, which can undergo a specific amination with primary amines to trigger luminescence change and photoarrangement under UV irradiation at the same active site. Detailed mechanistic insights were carried out to illustrate the reactivity and reaction pathways. Accordingly, multiple‐colored images, a quick response code with dynamic colors, and an all‐round information encryption system were demonstrated to show the properties of multiple controls and responses. It is believed that this work not only provides a strategy to develop multiresponsive luminogens but also develops an information encryption system based on luminescent materials.
Photoactivatable aggregation-induced emission probes for lipid droplets-specific live cell imaging
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6SC04842K
Abstract: Photoactivatable probes for lipid droplets (LDs)-specific live-cell imaging are powerful tools for investigating their biological functions through precise spatial and temporal control.
Stimulus-responsive room temperature phosphorescence materials with full-color tunability from pure organic amorphous polymers
Publisher: American Association for the Advancement of Science (AAAS)
Date: 25-02-2022
Abstract: Achieving stimulus-responsive ultralong room temperature phosphorescence (RTP) in organic materials especially with full-color tunable emissions is attractive and important but rarely reported. Here, a strategy was reported to realize stimulus-responsive RTP effect with color-tunable emissions by using water as solvent in the preparation process without any organic solvent through covalent linkage of arylboronic acids with different π conjugations and polymer matrix of polyvinyl alcohol. The yielded polymer films exhibit outstanding RTP performance (2.43 s). Furthermore, an excitation-dependent RTP film was obtained, and the afterglow color changes from blue to green, then to red as the excitation wavelength increases. The RTP property of all the above materials is sensitive to water and heat stimuli, because the rigidity of the system could be broken by water. Last, they were successfully applied in a multilevel information encryption and multicolor paper and ink.
Visualization and Manipulation of Molecular Motion in the Solid State through Photoinduced Clusteroluminescence
Publisher: American Chemical Society (ACS)
Date: 30-10-2019
DOI: 10.1021/ACS.JPCLETT.9B02752
Abstract: The development of molecular machines has long been a dream of scientists and is expected to revolutionize many aspects of technology and medicine. As the prerequisite of a practicable molecular machine, studies on the solid-state molecular motion (SSMM) are not only of scientific importance but also practically useful. Herein, two nonconjugated molecules, 1,2-diphenylethane (
Each phenyl group performs its own functions on luminescence: phenyl substituted effect in tetraphenylpyrazine
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0QM00098A
Abstract: Three phenyl groups of TPP derivatives affect the luminescence process in various modes. TPPs show AIE thanks to the ortho substituted groups, while meta and para groups can modulate their luminescence in different extents.
Aggregation‐Induced Nonlinear Optical Effects of AIEgen Nanocrystals for Ultradeep In Vivo Bioimaging
Publisher: Wiley
Date: 16-09-2019
Abstract: Nonlinear optical microscopy has become a powerful tool in bioimaging research due to its unique capabilities of deep optical sectioning, high-spatial-resolution imaging, and 3D reconstruction of biological specimens. Developing organic fluorescent probes with strong nonlinear optical effects, in particular third-harmonic generation (THG), is promising for exploiting nonlinear microscopic imaging for biomedical applications. Herein, a simple method for preparing organic nanocrystals based on an aggregation-induced emission (AIE) luminogen (DCCN) with bright near-infrared emission is successfully demonstrated. Aggregation-induced nonlinear optical effects, including two-photon fluorescence (2PF), three-photon fluorescence (3PF), and THG, of DCCN are observed in nanoparticles, especially for crystalline nanoparticles. The nanocrystals of DCCN are successfully applied for 2PF microscopy at 1040 nm NIR-II excitation and THG microscopy at 1560 nm NIR-II excitation, respectively, to reconstruct the 3D vasculature of the mouse cerebral vasculature. Impressively, the THG microscopy provides much higher spatial resolution and brightness than the 2PF microscopy and can visualize small vessels with diameters of ≈2.7 µm at the deepest depth of 800 µm in a mouse brain. Thus, this is expected to inspire new insights into the development of advanced AIE materials with multiple nonlinearity, in particular THG, for multimodal nonlinear optical microscopy.
A nonconjugated radical polymer with stable red luminescence in the solid state
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2MH00808D
Abstract: A radical polymer without any delocalized π-stabilization was synthesized from a classical chromophore quencher, TEMPO, which surprisingly shows red emission.
Preparation of Ultrasmall AIE Nanoparticles with Tunable Molecular Packing via Freeze Assembly
Publisher: American Chemical Society (ACS)
Date: 30-01-2023
Aggregation-Induced Emission Luminogen-Based Dual-Mode Enzyme-Linked Immunosorbent Assay for Ultrasensitive Detection of Cancer Biomarkers in a Broad Concentration Range
Publisher: American Chemical Society (ACS)
Date: 18-02-2022
DOI: 10.1021/ACSSENSORS.1C02237
Abstract: The enzyme-linked immunosorbent assay (ELISA) is one of the most commonly used methods for measuring antibodies and antigens in biological s les. However, developing new ELISAs with high detection sensitivity and broad detection dynamic ranges without resorting to complicated signal processing and equipment setups remains a challenge. In this work, we report a strategy to simultaneously improve the detection sensitivity and broaden the dynamic range by replacing the chromogenic reagents used in traditional ELISAs with an aggregation-induced emission luminogen (AIEgen). The developed AIE-ELISA could generate complementary absorbance and fluorescence signals with a linear detection range of 1.6-25,000 pg/mL. The application of this dual-mode AIE-ELISA in the detection of the prostate-specific antigen (PSA) realized a limit of detection of 1.3 pg/mL (3.78 × 10
A Dual‐Functional Photosensitizer for Ultraefficient Photodynamic Therapy and Synchronous Anticancer Efficacy Monitoring
Publisher: Wiley
Date: 07-06-2019
Turning on Light Emission of a Dark Pro‐Aggregation‐Induced Emission Luminogen in Aqueous Media Through Reductase‐Modulated Derotation
Publisher: Wiley
Date: 08-02-2021
NIR‐II AIEgens: A Win–Win Integration towards Bioapplications
Publisher: Wiley
Date: 15-12-2020
Boosting Non‐Radiative Decay to Do Useful Work: Development of a Multi‐Modality Theranostic System from an AIEgen
Publisher: Wiley
Date: 20-03-2019
Abstract: The efficient utilization of energy dissipating from non-radiative excited-state decay of fluorophores was only rarely reported. Herein, we demonstrate how to boost the energy generation of non-radiative decay and use it for cancer theranostics. A novel compound (TFM) was synthesized which possesses a rotor-like twisted structure, strong absorption in the far red/near-infrared region, and it shows aggregation-induced emission (AIE). Molecular dynamics simulations reveal that the TFM aggregate is in an amorphous form consisting of disordered molecules in a loose packing state, which allows efficient intramolecular motions, and consequently elevates energy dissipation from the pathway of thermal deactivation. These intrinsic features enable TFM nanoparticles (NPs) to display a high photothermal conversion efficiency (51.2 %), an excellent photoacoustic (PA) effect, and effective reactive oxygen species (ROS) generation. In vivo evaluation shows that the TFM NPs are excellent candidates for PA imaging-guided phototherapy.
In Situ Synthesis of AIEgen‐based Porous Organic Polymer Films by Interfacial Amino‐yne Click Polymerization for Efficient Light‐Harvesting
Publisher: Wiley
Date: 23-03-2023
Abstract: We developed a catalyst‐free, atom‐economical interfacial amino‐yne click polymerization to in situ synthesize new aggregation‐induced emission luminogen (AIEgen)‐based free‐standing porous organic polymer films at room temperature. The crystalline properties of POP films were confirmed by powder X‐ray diffraction and high‐resolution transmission electron microscopy. The good porosity of these POP films was proved by their N 2 uptake experiments. The thickness of POP films can be easily regulated from 16 nm to ≈1 μm by adjusting monomer concentration. More importantly, these AIEgen‐based POP films show bright luminescence with high absolute photoluminescent quantum yields up to 37.8 % and good chemical and thermal stability. The AIEgen‐based POP film can encapsulate an organic dye (e.g., Nile red) to further form an artificial light‐harvesting system with a large red‐shift (Δ λ =141 nm), highly efficient energy‐transfer ability ( Φ ET =91 %), and high antenna effect (11.3).
Surface Effect on the Self-Assembly of Nanofibers Revealed by in Situ AFM Imaging and Molecular Simulation
Publisher: American Chemical Society (ACS)
Date: 21-03-2019
Liquid capsules for gastrointestinal drug delivery
Publisher: Elsevier BV
Date: 10-2022
One-pot three-component polymerization for in situ generation of AIE-active poly(tetraarylethene)s using Grignard reagents as building blocks
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0PY00874E
Abstract: A facile polymerization route for in situ generation of polymers with aggregation-induced emission (AIE) characteristics has been developed.
Recent advances in cation sensing using aggregation-induced emission
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0QM00607F
Abstract: This review summarizes recent advances in AIE-based chemosensors for the detection of a wide range of metal cations, outlining the various sensing mechanisms and sensing performances such as sensitivity and selectivity of AIE-based chemosensors.
Molecular Motions in AIEgen Crystals: Turning on Photoluminescence by Force-Induced Filament Sliding
Publisher: American Chemical Society (ACS)
Date: 28-07-2020
DOI: 10.1021/JACS.0C06305
Robust Serum Albumin-Responsive AIEgen Enables Latent Bloodstain Visualization in High Resolution and Reliability for Crime Scene Investigation
Publisher: American Chemical Society (ACS)
Date: 25-04-2019
Abstract: Bloodstains provide admissible information for crime scene investigators. The ability to resolve latent bloodstains that are commonly found in real scenarios is therefore pivotal to public security. Here, we report a facile approach for invisible bloodstain visualization based on the click reaction between serum albumin and tetraphenylethene maleimide (TPE-MI), an aggregation-induced emission luminogen (AIEgen). Compared to the widely adopted methods based on the harsh catalytic oxidation activity of hemoglobin, this working principle benefits from the specificity of the mild catalyst-free thiol-ene click reaction that improves the reliability and resolution. In addition, the mild conditions preserve DNA information and bloodstain patterns, and the excellent photophysical properties of the AIEgen afford high sensitivity and stability (>1 yr). Such an excellent performance cannot be achieved by conventional AIEgens and aggregation-caused quenching luminogens with similar structures. TPE-MI outperforms the benchmark luminol-based technique in visualizing latent bloodstains as showcased in two mock crime scenes: spattered blood track and transfer blood fingerprint. This disclosed method is an advancement in forensic science that could inspire future development of technology for bloodstain visualization.
Design of multi-functional AIEgens: tunable emission, circularly polarized luminescence and self-assembly by dark through-bond energy transfer
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TC02504E
Abstract: A pair of chiral R / S -TPE-BINOL derivatives with dark resonance energy transfer was synthesized using a tetraphenylethylene derivative as a dark energy donor which also endows the target molecules with aggregation-induced emission characteristics, BODIPY as an energy acceptor and BINOL as a chiral source.
Correction to “Uptake, Distribution, and Bioimaging Applications of Aggregation-Induced Emission Saponin Nanoparticles in Arabidopsis thaliana”
Publisher: American Chemical Society (ACS)
Date: 04-06-2019
Shape-Persistent π-Conjugated Macrocycles with Aggregation-Induced Emission Property: Synthesis, Mechanofluorochromism, and Mercury(II) Detection
Publisher: American Chemical Society (ACS)
Date: 23-08-2019
Abstract: Shape-persistent conjugated macrocycles are fundamentally important because of their unique structure and properties. Herein, a series of π-conjugated macrocycles with a shape-persistent architecture, an adaptive backbone, and aggregation-induced emission (AIE) properties are synthesized via oxidative coupling of acetylene-terminated tetraphenylethylene precursor with a half-ring topology and following transformation from butadiynylene linkers into thienylene ones. Characterization by NMR spectroscopy and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry provided unambiguous proofs for the macrocyclic structures. In particular, the free rotation of aromatic rings in the rigid macrocyclic backbone was validated by two-dimensional NMR spectroscopy, variable-temperature NMR measurements, and theoretical calculations. Moreover, these shape-persistent macrocyclic chromophores all exhibited obvious AIE phenomena and remarkable mechanofluorochromism behaviors with a red-shifted luminescence upon grinding and blue-shifted emission after solvent annealing. Also, the introduction of S atoms into the macrocyclic frameworks endowed the macrocyclic luminogen the capability to selectively detect mecury(II) ions in aqueous media among other metal ions.
Noncancerous disease-targeting AIEgens
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D2CS00610C
Abstract: Schematic diagram of noncancerous disease-targeting AIEgens.
Clusteroluminescence from Cluster Excitons in Small Heterocyclics Free of Aromatic Rings
Publisher: Wiley
Date: 11-02-2021
Creation of Efficient Blue Aggregation-Induced Emission Luminogens for High-Performance Nondoped Blue OLEDs and Hybrid White OLEDs
Publisher: American Chemical Society (ACS)
Date: 23-04-2019
Abstract: Organic blue luminescent materials are essential for organic light-emitting diodes (OLEDs). However, high-quality blue materials that can fulfill the requirements of OLED commercialization are much rare. Herein, two novel blue luminogens, 9-(4-(2,6-di- tert-butyl-10-(4-(1,2,2-triphenylvinyl)phenyl)anthracen-9-yl)phenyl)-9 H-carbazole and 9-(4-(2,6-di- tert-butyl-10-(4-(1,2,2-triphenylvinyl)phenyl)anthracen-9-yl)1,3-di(9 H-carbazol-9-yl)benzene (TPE-TADC), consisting of anthracene, tetraphenylethene, and carbazole groups are successfully prepared, and their thermal, optical, electronic, and electrochemical properties are fully investigated. They exhibit prominent aggregation-induced emission property and strong blue fluorescence at ∼455 nm in neat films. Efficient nondoped OLEDs are fabricated with these blue luminogens, providing blue electroluminescence (EL) at 451 nm (CIE
Circularly polarized luminescence from oriented polymer films doped with a tetraphenylethylene-based conjugated oligomer
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1QM00482D
Abstract: Oriented polymer films fabricated by photopolymerization of cholesteric liquid crystalline mixtures doped with a tetraphenylethylene-based conjugated oligomer can emit strong yellow-orange CPL with absolute g lum values up to 0.77 and Φ F up to 60.4%.
Diversified Photo/Electronic Functions Based on a Simple Chalcone Skeleton: Effects of Substitution Pattern and Molecular Packing
Publisher: Wiley
Date: 18-01-2018
Room-temperature phosphorescence from organic aggregates
Publisher: Springer Science and Business Media LLC
Date: 18-08-2020
Dual-Mode Ultrasensitive Detection of Nucleic Acids via an Aqueous “Seesaw” Strategy by Combining Aggregation-Induced Emission and Plasmonic Colorimetry
Publisher: American Chemical Society (ACS)
Date: 16-11-2018
Hydrophilicity‐Hydrophobicity Transformation, Thermoresponsive Morphomechanics, and Crack Multifurcation Revealed by AIEgens in Mechanically Strong Hydrogels
Publisher: Wiley
Date: 04-08-2021
Abstract: Biomimetic exploration of stimuli‐responsive and crack‐resistant hydrogels is of great academic and practical significance, although the rational design of tough hydrogels is limited by insufficient mechanism study due to the lack of imaging techniques to “see” hydrogels at mesoscale level. A series of composite hydrogels with compartmentalized thermal response is designed by incorporating aggregation‐ and polarity‐sensitive fluorescent probes in a poly( N ‐isopropylacrylamide) (PNIPAM) network grafted with poly( N , N ‐dimethylacrylamide) side‐chains. The fluorescence technique is explored as a powerful tool to directly visualize their hydrophilicity‐hydrophobicity transformation and the composition‐dependent microphase separation. Based on the morphological observation and mechanical measurements, the concept of morphomechanics with a comprehensive mechanism clarification is proposed. In this regard, the thermoresponsive toughening is attributed to the formation of multiple noncovalent interactions and the conformational changes of PNIPAM chains. The enhanced fracture energy by crack multifurcation is related to the tearing‐like disruption of weak interfaces between the separated phases.
Correction to “Single-Molecular Near-Infrared-II Theranostic Systems: Ultrastable Aggregation-Induced Emission Nanoparticles for Long-Term Tracing and Efficient Photothermal Therapy”
Publisher: American Chemical Society (ACS)
Date: 06-06-2022
Innovative Verfahren zur Synthese von Luminogenen mit aggregationsinduzierter Emission
Publisher: Wiley
Date: 09-02-2021
Abstract: Wegen ihrer Vorteile haben Luminogene mit aggregationsinduzierter Emission (AIEgene) in einer Reihe von Anwendungsbereichen weltweit wachsendes Interesse auf sich gezogen. Während allgemeine Verfahren zur Synthese von AIEgenen im Wesentlichen auf schwierigen Abläufen und eingeschränkten Reaktionstypen beruhen, haben sich in diesem Zusammenhang verschiedene innovative Syntheseverfahren als ergänzende oder sogar alternative Strategien herausgebildet. In diesem Aufsatz zeigen wir systematisch die neuesten Fortschritte bei der metallkatalysierten Funktionalisierung und den nicht metallgeförderten Wegen zum Aufbau von AIEgenen der letzten fünf Jahre auf und erläutern kurz neue Perspektiven auf diesem Gebiet. Die Entwicklung innovativer Verfahren ist vielversprechend für die zukünftige Herstellung von AIEgenen, wobei eine einfache Synthese, eine große Strukturvielfalt und multifunktionale Anwendungen ermöglicht werden sollen.
Side‐Chain Engineering of Aggregation‐Induced Emission Molecules for Boosting Cancer Phototheranostics
Publisher: Wiley
Date: 18-09-2021
Abstract: The ingenious construction of versatile cancer phototheranostics involving fluorescence imaging (FLI) and photodynamic and photothermal therapies (PDT, PTT) concurrently has attracted great interest. By virtue of their inherent twisted structures and plentiful motion moieties, aggregation‐induced emission luminogens (AIEgens) have been proven to be perfect templates for the development of multimodal phototheranostic systems as their erse energy consumption pathways can be flexibly regulated through tuning the intramolecular motions. Side‐chain engineering is generally accepted as a useful regulation strategy for intramolecular motions through altering the side‐chain structure of the molecule, but has rarely been reported for the construction of AIE‐active multimodal phototheranostics. Herein, by taking full advantage of the side‐chain engineering strategy, an AIE‐active multifunctional phototheranostic system (TBFT2 nanoparticles) is successfully constructed by intentionally manipulating the length of side chains. Bearing the longest alkyl chain, all of those three energy dissipation pathways including radiative decay, nonradiative thermal deactivation, and intersystem crossing process of TBFT2 are retained simultaneously and controllably in the aggregate state. In vitro and in vivo evaluations verify that TBFT2 nanoparticles perform well in terms of FLI‐guided PDT and PTT synergistic cancer therapy. This study thus provides new insight into the exploration of superior versatile phototheranostics through side‐chain engineering.
Hydrazine Detection during Ammonia Electro-oxidation Using an Aggregation-Induced Emission Dye
Publisher: American Chemical Society (ACS)
Date: 28-01-2021
DOI: 10.1021/JACS.0C13178
Which is a better fluorescent sensor: aggregation-induced emission-based nanofibers or thin-coating films?
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0MA00409J
Abstract: Aggregation-induced emission (AIE)-based fluorescent nanofibers (FNFs) and thin-coating films (FTFs) are employed as visual fluorescent sensors, and their performance dynamics is compared.
Heteroaromatic Hyperbranched Polyelectrolytes: Multicomponent Polyannulation and Photodynamic Biopatterning
Publisher: Wiley
Date: 17-06-2021
Abstract: We reported an efficient multicomponent polyannulation for in situ generation of heteroaromatic hyperbranched polyelectrolytes by using readily accessible internal diynes and low‐cost, commercially available arylnitriles, NaSbF 6 , and H 2 O/AcOH. The polymers were obtained in excellent yields (up to 99 %) with extraordinary high molecular weights (M w up to 1.011×10 6 ) and low polydispersity indices. The resulting polymers showed good processibility and high quantum yields with tunable emission in the solid state, making them ideal materials for highly ordered fluorescent photopatterning. These hyperbranched polyelectrolytes also possessed strong ability to generate reactive oxygen species, which allowed their applications in efficient bacterial killing and customizable photodynamic patterning of living organisms in a simple and cost‐effective way.
How Do Molecular Motions Affect Structures and Properties at Molecule and Aggregate Levels?
Publisher: American Chemical Society (ACS)
Date: 06-2021
DOI: 10.26434/CHEMRXIV.14703822.V1
Abstract: Experimental and theoretical analysis demonstrated that the active intramolecular motions in the excited state of all molecules at single molecule level imparted them with more twisted structural conformations and weak emission. However, owing to the restriction of intramolecular motions in the nano/macro aggregate state, all the molecules assumed less twisted conformations with bright emission. Synergic strong and weak intermolecular interactions allowed their crystals to undergo reversible deformation, which effectively solved the problem of the brittles of organic crystals, meanwhile imparted them with excellent elastic performance.
In Situ Monitoring Apoptosis Process by a Self-Reporting Photosensitizer
Publisher: American Chemical Society (ACS)
Date: 28-03-2019
DOI: 10.1021/JACS.9B00636
Abstract: Although photodynamic therapy (PDT) has thrived as a promising treatment, highly active photosensitizers (PSs) and intense light power can cause treatment overdose. However, extra therapeutic response probes make the monitoring process complicated, ex situ and delayed. Now, this challenge is addressed by a self-reporting cationic PS, named TPE-4EP+, with aggregation-induced emission characteristic. The molecule undergoes mitochondria-to-nucleus translocation during apoptosis induced by PDT, thus enabling the in situ real-time monitoring via fluorescence migration. Moreover, by molecular charge engineering, we prove that the in situ translocation of TPE-4EP+ is mainly attributed to the enhanced interaction with DNA imposed by its multivalent positive charge. The ability of PS to provide PDT with real-time diagnosis help control the treatment dose that can avoid excessive phototoxicity and minimize potential side effect. Future development of new generation of PS is envisioned.
An aggregation-induced emission platform for efficient Golgi apparatus and endoplasmic reticulum specific imaging
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1SC03932F
Abstract: As two important subcellular organelles in eukaryotic cells, the Golgi apparatus (GA) and endoplasmic reticulum (ER) have recently captivated much interest due to their considerable importance in many biofunctions and role as critical biomarkers for various diseases.
Molecular Engineering of AIE Photosensitizers for Inactivation of Rabies Virus
Publisher: Wiley
Date: 10-07-2023
Abstract: Rabies is a zoonotic neurological disease caused by the rabies virus (RABV) that is fatal to humans and animals. While several post‐infection treatment have been suggested, developing more efficient and innovative antiviral methods are necessary due to the limitations of current therapeutic approaches. To address this challenge, a strategy combining photodynamic therapy and immunotherapy, using a photosensitizer (TPA‐Py‐PhMe) with high type I and type II reactive oxygen species (ROS) generation ability is proposed. This approach can inactivate the RABV by killing the virus directly and activating the immune response. At the cellular level, TPA‐Py‐PhMe can reduce the virus titer under preinfection prophylaxis and postinfection treatment, with its antiviral effect mainly dependent on ROS and pro‐inflammatory factors. Intriguingly, when mice are injected with TPA‐Py‐PhMe and exposed to white light irradiation at three days post‐infection, the onset of disease is delayed, and survival rates improved to some extent. Overall, this study shows that photodynamic therapy and immunotherapy open new avenues for future antiviral research.
Tetraphenylbenzene-based AIEgens: horizontally oriented emitters for highly efficient non-doped deep blue OLEDs and hosts for high-performance hybrid WOLEDs
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0TC00920B
Abstract: Non-doped deep blue OLEDs and hybrid WOLEDs with high performance and low efficiency roll-off are reported based on tetraphenylbenzene-cored AIEgens.
Aggregation induced emission (AIE) active cross-linked poly(N-isopropyl acrylamide-co-tetra(phenyl)ethene di-acrylates): sensors for effective nitroaromatics detection in an aqueous environment
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1TC06068F
Abstract: The fluorescence of AIE active polymer CP1-4 in water could be quenched by many nitroaromatics. The detection sensitivity of CP1-4 could be greatly improved to the levels as 0.25 ppm by a collapsing-swelling process.
C(sp3)–H Polyamination of Internal Alkynes toward Regio- and Stereoregular Functional Poly(allylic tertiary amine)s
Publisher: American Chemical Society (ACS)
Date: 30-04-2020
Circularly Polarized Luminescence from Chiral Conjugated Poly(carbazole-ran-acridine)s with Aggregation-Induced Emission and Delayed Fluorescence
Publisher: American Chemical Society (ACS)
Date: 07-01-2019
De Novo Design of Reversibly pH-Switchable NIR-II Aggregation-Induced Emission Luminogens for Efficient Phototheranostics of Patient-Derived Tumor Xenografts
Publisher: American Chemical Society (ACS)
Date: 27-12-2022
DOI: 10.1021/JACS.2C10076
A Bright Two‐Photon Lipid Droplets Probe with Viscosity‐Enhanced Solvatochromic Emission for Visualizing Lipid Metabolic Disorders in Deep Tissues
Publisher: Wiley
Date: 08-05-2023
Abstract: The polarity of lipid droplets (LDs) plays an important role in pathological processes associated with abnormal lipid metabolism. Monitoring the variation of LDs polarity in cells and tissues is of great importance in biomedical research and clinical diagnosis. However, developing fluorescent LDs‐specific probes with high polarity sensitivity, brightness, and permeability for deep tissue imaging is still challenging. Herein, a push–pull fluorescent luminogen (DPBT) with aggregation‐induced emission, strong solvatochromism, large Stokes shift, high solid‐state fluorescence efficiency and superior two‐photon absorption is facilely developed. The lipophilic DPBT can specifically stain LDs with high biocompatibility and good photostability. The viscosity‐enhanced solvatochromic emission property enables DPBT to visualize LDs polarity with high brightness and imaging contrast, and deep penetration depth under two‐photon microscopy. DPBT can specifically stain lipids in various mouse tissues (atherosclerotic plaque, liver, and mesenteric adipose tissues) and map their polarity distribution to reflect lipid metabolic states within those tissues. It is found that the lipids deposition as well as their polarity distribution in tissues of hyperlipoidemia mouse are clearly different from the tissues of the normal mouse. Its excellent properties make DPBT a promising candidate for investigating LDs‐associated physiological and pathological processes in live biological s les.
Tuning molecular emission of organic emitters from fluorescence to phosphorescence through push-pull electronic effects
Publisher: Springer Science and Business Media LLC
Date: 26-05-2020
DOI: 10.1038/S41467-020-16412-4
Abstract: Organic emitters with persistent phosphorescence have shown potential application in optoelectronic devices. However, rational design and phosphorescence tuning are still challenging. Here, a series of metal-free luminophores without heavy atoms and carbonyl groups from commercial/lab-synthesized carbazole and benzene were synthesized to realize tunable molecular emission from fluorescence to phosphorescence by simply substituent variation. All the molecules emit blue fluorescence in both solution and solid state. Upon removal of excitation source, the fluorinated luminophores show obvious phosphorescence. The lab-synthesized carbazole based molecules exhibit a huge lifetime difference to the commercially purchased ones due to the existence of isomer in the latter s les. The small energy gap between singlet and triplet state and low reorganization energy help enhance intersystem crossing to contribute to a more competitive radiative process from triplet to ground state. Blue and white organic light-emitting devices are fabricated by using fluorinated luminophore as emitting layer.
An Intelligent AIEgen with Nonmonotonic Multiresponses to Multistimuli
Publisher: Wiley
Date: 06-09-2020
Amphiphilic Tetraphenylethene-Based Pyridinium Salt for Selective Cell-Membrane Imaging and Room-Light-Induced Special Reactive Oxygen Species Generation
Publisher: American Chemical Society (ACS)
Date: 25-02-2019
Abstract: The cell membrane is the protecting frontier of cells, which is crucial for maintaining cell integrity, and has a close relationship with cell growth and death. There is a growing need for cell membrane imaging and monitoring in both living and dying cells. Herein, we report a new hiphilic tetraphenylethene-based pyridinium salt (TPE-MEM) with aggregation-induced emission features for discriminatory cell membrane imaging. The fluorogenic probe with high yield was synthesized following asymmetric McMurry reaction, Williamson ether synthesis reaction, Suzuki coupling, and aldol condensation between a double-charged pyridinium salt and hexyloxytetraphenylethene benzaldehyde. TPE-MEM shows good water solubility, biocompatibility, and cell membrane specificity. Interestingly, a reactive oxygen species (ROS) is produced by the molecule (TPE-MEM) under room-light irradiation, which could destroy the integrity of the plasma membrane and cause cell necrosis. This enables a visible observation of cell necrosis and the phototherapeutic effect under a mild condition. Preliminary animal investigations also demonstrated the photodynamic therapy (PDT) effectiveness of TPE-MEM in tumor growth inhibition. We conclude that TPE-MEM is potentially a cell membrane-selective photosensitizer for PDT and it is worthy of further exploration of the phototherapeutic effect on animals systematically.
Laser-Engineered Graphene on Wood Enables Efficient Antibacterial, Anti-Salt-Fouling, and Lipophilic-Matter-Rejection Solar Evaporation
Publisher: American Chemical Society (ACS)
Date: 09-11-2020
Substitution Activated Precise Phototheranostics through Supramolecular Assembly of AIEgen and Calixarene
Publisher: American Chemical Society (ACS)
Date: 19-08-2020
DOI: 10.1021/JACS.0C06872
Ferrocene-based hyperbranched poly(phenyltriazolylcarboxylate)s: synthesis by phenylpropiolate-azide polycycloaddition and use as precursors to nanostructured magnetoceramics
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9PY01375J
Abstract: Ferrocene-based hb -PPTCs with redox activity are readily prepared by the catalyst-free phenylpropiolate-azide polycycloaddition. They could be used as precursors to produce nanostructured magnetoceramics upon pyrolysis.
Pressure/Thermo-Induced Hypsochromic-Shifted and Enhanced Luminescence Based on Carbazole Emitter
Publisher: American Chemical Society (ACS)
Date: 11-04-2023
Vision Defense: Efficient Antibacterial AIEgens Induced Early Immune Response for Bacterial Endophthalmitis
Publisher: Wiley
Date: 06-07-2022
Abstract: Bacterial endophthalmitis (BE) is an acute eye infection and potentially irreversible blinding ocular disease. The empirical intravitreous injection of antibiotic is the primary treatment once diagnosed as BE. However, the overuse of antibiotic contributes to the drug resistance of pathogens and the retinal toxicity of antibiotic limits its application in clinic. Herein, a cationic aggregation‐induced emission luminogens named with triphenylamine thiophen pyridinium (TTPy) is reported for photodynamic treatment of BE. TTPy can selectively discriminate and kill bacteria efficiently over normal ocular cells. More importantly, TTPy shows excellent antibacterial ability in BE rat models infected by Staphylococcus aureus . Meanwhile, the bacterial killing behavior triggered by TTPy induces innate immune response at an early stage of infection, limiting subsequent robust inflammation and protecting retina from bacterial toxins and inflammation‐induced bystander damage. In addition, TTPy performs better antibacterial ability than commercially used Rose Bengal, suggesting its excellent capability of vision salvage in acute BE. This study exhibits an efficient photodynamic antibacterial treatment to BE, which induces an early intraocular immune response and saves useful vision, endowing TTPy a promising potential for clinical application of ocular infections.
A Conjugated Polymeric Supramolecular Network with Aggregation‐Induced Emission Enhancement: An Efficient Light‐Harvesting System with an Ultrahigh Antenna Effect
Publisher: Wiley
Date: 03-09-2020
Spatially and Reversibly Actuating Soft Gel Structure by Harnessing Multimode Elastic Instabilities
Publisher: American Chemical Society (ACS)
Date: 22-07-2021
“Exciton Recovery” Strategy in Hot Exciton Emitter toward High‐Performance Non‐Doped Deep‐Blue and Host‐Sensitized Organic Light‐Emitting Diodes
Publisher: Wiley
Date: 05-01-2023
Abstract: The “hot exciton” mechanism based on high‐lying reverse intersystem crossing process has great advantages in achieving high‐performance deep‐blue organic light‐emitting diodes (OLEDs). Nevertheless, how to solve the loss of high‐lying excitons to improve device performance further is a pressing and challenging issue. To break through this shackle, a novel deep‐blue emitter based on “exciton recovery” strategy is successfully design, namely CAT. By combining the transient absorption spectrum, theoretical calculation, magneto‐electroluminescence, and transient‐electroluminescence measurements, the multi‐channeled pathways of excitons utilization via hot exciton and triplet‐triplet annihilation processes is comprehensively demonstrated, and the proportion of singlet excitons by each channel. Finally, a high exciton utilization efficiency is successfully achieved, and the non‐doped OLED based on CAT exhibit an excellent external quantum efficiency of 10.39% with the CIE coordinates of (0.15, 0.087). Furthermore, the sensitized blue fluorescent OLED by CAT as host also achieves excellent performance. More importantly, the operational lifetime of the “multi‐channel” sensitized device is evaluated for the first time, performing the remarkable LT 50 (lifetime to 50% of the initial luminance) of 320 h at 540 cd m −2 . These results fully reveal the significance of the “exciton recovery” strategy and give new inspiration for exploring high‐performance blue OLEDs.
Direct Conversion from Carbon Dioxide to Luminescent Poly(β-alkoxyacrylate)s via Multicomponent Tandem Polymerization-Induced Emission
Publisher: American Chemical Society (ACS)
Date: 19-05-2021
DOI: 10.26434/CHEMRXIV.14601729.V1
Abstract: Using carbon dioxide (CO 2 ) as a feedstock to synthesize various polymers has drawn much attention. One-pot multicomponent tandem polymerization (MCTP) with great synthetic simplicity and efficiency is a powerful strategy for the synthesis of new CO 2 -based luminescent polymers. In this work, we successfully developed a new one-pot MCTP combining three sequential carboxylation-cyclization-esterification reactions of CO 2 , diynes and alkyl dihalides to direct fixing CO 2 into luminescent polymers with aggregation-enhanced emission (AEE) property. This MCTP could be facilely carried out in N,N -dimethylacetamide in the presence of a cheap catalyst CuI and an organic base 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene under atmospheric pressure. A series of poly( β -alkoxyacrylate)s with well-defined structures, high molecular weights ( M w up to 15 400) were obtained in high yields (up to 96%). The resultant polymers possess good thermal stability with high decomposition temperature and high char yield. Due to polymerization-induced emission (PIE) behavior, the non-luminescent monomers could be converted to luminescent poly( β -alkoxyacrylate)s with AEE features. Thus, this work provides a new pathway to directly transform CO 2 into luminescent polymers via a one-pot MCTP strategy.
Functionalized Acrylonitriles with Aggregation-Induced Emission: Structure Tuning by Simple Reaction-Condition Variation, Efficient Red Emission, and Two-Photon Bioimaging
Publisher: American Chemical Society (ACS)
Date: 22-08-2019
DOI: 10.1021/JACS.9B06196
Abstract: Acrylonitriles with aggregation-induced emission (AIE) characteristics have been found to show promising applications in two-photon biomedical imaging. Generally, elaborate synthetic efforts are required to achieve different acrylonitriles with distinct functionalities. In this work, we first reported the synthesis of two different group-functionalized AIE-active acrylonitriles (TPAT-AN-XF and 2TPAT-AN) obtained simply by mixing the same reactants at different temperatures using a facile and transition metal-free synthetic method. These two AIE luminogens (AIEgens) exhibit unique properties such as bright red emission in the solid state, large Stokes shift, and large two-photon absorption cross section. Water-soluble nanoparticles (NPs) of 2TPAT-AN were prepared by a nanoprecipitation method. In vitro imaging data show that 2TPAT-AN NPs can selectively stain lysosome in live cells. Besides one-photon imaging, remarkable two-photon imaging of live tumor tissues can be achieved with high resolution and deep tissue penetration. 2TPAT-AN NPs show high biocompatibility and are successfully utilized in in vivo long-term imaging of mouse tumors with a high signal-to-noise ratio. Thus, the present work is anticipated to shed light on the preparation of a library of AIE-active functionalized acrylonitriles with intriguing properties for biomedical applications.
Aptamer-Decorated Self-Assembled Aggregation-Induced Emission Organic Dots for Cancer Cell Targeting and Imaging
Publisher: American Chemical Society (ACS)
Date: 28-12-2017
DOI: 10.1021/ACS.ANALCHEM.7B03933
Abstract: A facile and simple one-step method was developed to fabricate aptamer-decorated self-assembled organic dots with aggregation-induced emission (AIE) characteristics. With integration of the advantages of AIE aggregates with strong emission and the cell-targeting capability of aptamers, the as-prepared Apt-AIE organic nanodots can specifically target to cancer cells with good biocompatibility, high image constrast, and photostability. On the basis of this universal method, a variety of versatile organic fluorescent nanoprobes with high brightness, specific recognition, and clinical-transitional potential could be facilely constructed for biological sensing and imaging applications.
Multiple Anti‐Counterfeiting Guarantees from a Simple Tetraphenylethylene Derivative – High‐Contrasted and Multi‐State Mechanochromism and Photochromism
Publisher: Wiley
Date: 22-10-2019
Abstract: Herein the novel tetraphenylethylene (TPE) derivative 1 was designed with an integration of aggregation-induced emission (AIE), multi-state mechanochromism and self-recovery photochromism. The molecule was susceptible to grinding, heating and vapor fuming and showed corresponding transition of its emission colors. The heated powder or single crystal of 1 exhibited reversible photochromism. After a short period of UV irradiation, it showed a bright red color, but recovered to its original white appearance within 1 min. The photochromism is due to the formation of photocyclization intermediates upon UV irradiation, while the eversible mechanochromism is attributed to the weak molecular interactions derived from head-to-tail stacking of the molecules. This reversible multi-state, high-contrasted and rapid responsive mechanochromic and photochromic property cooperatively provide double enhancement of a multimode guarantee in advanced anti-counterfeiting.
Functional Polymer Systems with Aggregation-Induced Emission and Stimuli Responses
Publisher: Springer International Publishing
Date: 11-01-2022
A cell membrane-targeting AIE photosensitizer as a necroptosis inducer for boosting cancer theranostics
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2SC01260J
Abstract: A membrane-targeting photosensitizer TBMPEI with AIE properties was synthesized via a new acceptor, and it was utilized as a necroptosis inducer during imaging-guided photodynamic therapy.
Highly Emissive Organic Cage in Single-Molecule and Aggregate States by Anchoring Multiple Aggregation-Caused Quenching Dyes
Publisher: American Chemical Society (ACS)
Date: 22-11-2022
Abstract: It remains a great challenge to design and synthesize organic luminescent molecules with strong emission in both dilute solution and aggregate state. Herein, an organic cage with dodecadansyl groups (D-RCC1) from an easy sulfonation reaction displays strong emissive behavior in dilute organic solution with a quantum yield of 42%. Moreover, D-RCC1 exhibits an ultrahigh quantum yield of 92% in the solid state, which is more than 3 times that of 27% for the model compound D-DEA. The results of the experiment and theoretical calculation show that the three-dimensional symmetrical skeleton of the organic cage anchored evenly by multiple dye molecules effectively satisfies both high local density and a symmetrical distribution of chromophores, which prevents the interaction of dye molecules and ensures that dye molecules have strong emission in both single-molecule and aggregate states.
Click Synthesis Enabled Sulfur Atom Strategy for Polymerization‐Enhanced and Two‐Photon Photosensitization
Publisher: Wiley
Date: 23-03-2022
Abstract: Facile tailoring of photosensitizers (PSs) with advanced and synergetic properties is highly expected to broaden and deepen photodynamic therapy (PDT) applications. Herein, a catalyst‐free thiol–yne click reaction was employed to develop the sulfur atom‐based PSs by using the in situ formed sulfur “heavy atom effect” to enhance the intersystem crossing (ISC), while such an effect can be remarkably magnified by the polymerization. The introduction of a tetraphenylpyrazine‐based aggregation‐induced emission (AIE) unit was also advantageous in PS design by suppressing their non‐radiative decay to facilitate the ISC in the aggregated state. Besides, the resulting sulfur atom electron donor, together with a double‐bond π bridge and AIE electron acceptor, created a donor‐π‐acceptor (D‐π‐A) molecular system with good two‐photon excitation properties. Combined with the high singlet oxygen generation efficiency, the fabricated polymer nanoparticles exhibited an excellent in vitro two‐photon‐excited PDT towards cancer cells, therefore possessing a huge potential for the deep‐tissue disease therapy.
Cancer cell discrimination and dynamic viability monitoring through wash-free bioimaging using AIEgens
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0SC01213K
Abstract: We present a series of AIEgens for cancer cell discrimination and dynamic viability monitoring.
AIE polymers in sensing, imaging and theranostic applications
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1QM00078K
Abstract: This review summarizes the progress of AIE polymers in sensing, imaging and theranostic applications in the recent 3 years, and the perspective and future development of AIE polymers are discussed briefly.
Aggregationsinduzierte Emission: mehr ist anders
Publisher: Wiley
Date: 25-05-2020
Visual Multifunctional Aggregation‐Induced Emission‐Based Bacterial Cellulose for Killing of Multidrug‐Resistant Bacteria
Publisher: Wiley
Date: 29-04-2023
Abstract: Multidrug‐resistant (MDR) bacteria‐related wound infections are a thorny issue. It is urgent to develop new antibacterial wound dressings that can not only prevent wounds from MDR bacteria infection but also promote wound healing. Herein, an aggregation‐induced emission (AIE) molecule BITT‐composited bacterial cellulose (BC) is presented as wound dressings. BC‐BITT composites have good transparency, making it easy to monitor the wound healing process through the composite membrane. The BC‐BITT composites retain the advantages of biocompatible BC, and display photodynamic and photothermal synergistic antibacterial effects under irradiation of a 660 nm laser. Furthermore, the BC‐BITT composites show excellent wound healing performance in a mouse full‐thickness skin wound model infected by MDR bacteria, simultaneously with negligible toxicity. This work paves a way for treating clinically troublesome wound infections.
Inorganic–Organic Nanocomposites Based on Aggregation‐Induced Emission Luminogens
Publisher: Wiley
Date: 09-11-2020
The Golden Touch by Light: A Finely Engineered Luminogen Empowering High Photoactivatable and Photodynamic Efficiency for Cancer Phototheranostics
Publisher: Wiley
Date: 22-12-2022
Abstract: Photoactivatable agent is a powerful tool in biomedicine studies due to high‐precision spatiotemporal control of light. However, those previously reported agents generally suffer from short wavelength, fluorescence self‐quenching effect, and the lack of photosensitizing property, which severely restrict their practical applications. To address these issues, molecular engineering of 1,4‐dihydropyridine derivatives is conducted to obtain an optimized agent, namely TPA‐DHPy‐Py, which exhibits low oxidation potential, high photoactivation efficiency, and excellent type I/II combined photodynamic activity. Concurrently, its photoactivated counterpart is featured by aggregation‐induced near‐infrared emission and remarkable reactive oxygen species (ROS) production efficiency. Upon photoactivation, TPA‐DHPy‐Py is capable of precisely identifying cancer cells from co‐culturing cancer cells and normal cells without the assistance of any extra targeting units, and in situ monitoring lipid droplets and endoplasmic reticulum alteration under ROS stress, as well as achieving fluorescent visualization of tumor in vivo with supremely high imaging contrast. Furthermore, the unprecedented performance on photodynamic cancer therapy is demonstrated by the significant inhibition of tumor growth. Therefore, the photoactivatable TPA‐DHPy‐Py with dual‐organelle‐targeted and excellent photodynamic activity associated with self‐monitoring ability is highly promising for cancer theranostics in clinical trials.
Fluorescent Imaging and Sorting of High-Lipid-Content Strains of Green Algae by Using an Aggregation-Induced Emission Luminogen
Publisher: American Chemical Society (ACS)
Date: 13-09-2022
Abstract: Microalgae-based biofuels are receiving attention at the environmental, economic, and social levels because they are clean, renewable, and quickly produced. The green algae
Triple‐Jump Photodynamic Theranostics: MnO2 Combined Upconversion Nanoplatforms Involving a Type‐I Photosensitizer with Aggregation‐Induced Emission Characteristics for Potent Cancer Treatm
Publisher: Wiley
Date: 22-08-2021
Abstract: The development of multifunctional nanoplatforms has been recognized as a promising strategy for potent photodynamic theranostics. Aggregation‐induced emission (AIE) photosensitizers undergoing Type‐I reactive oxygen species (ROS) generation pathway appear as potential candidates due to their capability of hypoxia‐tolerance, efficient ROS production, and fluorescence imaging navigation. To further improve their performance, a facile and universal method of constructing a type of glutathione (GSH)‐depleting and near‐infrared (NIR)‐regulated nanoplatform for dual‐modal imaging‐guided photodynamic therapy (PDT) is presented. The nanoplatforms are obtained through the coprecipitation process involving upconversion nanoparticles (UCNPs) and AIE‐active photosensitizers, followed by in situ generation of MnO 2 as the outer shell. The introduction of UCNPs actualizes the NIR‐activation of AIE‐active photosensitizers to produce ·OH as a Type‐I ROS. Intracellular upregulated GSH‐responsive decomposition of the MnO 2 shell to Mn 2+ realizes GSH‐depletion, which is a distinctive approach for elevating intracellular ·OH. Meanwhile, the generated Mn 2+ can implement T 1 ‐weighted magnetic resonance imaging (MRI) in specific tumor sites, and mediate the conversion of intracellular H 2 O 2 to ·OH. These outputs reveal a triple‐jump ·OH production, and this approach brings about distinguished performance in FLI‐MRI‐guided PDT with high‐efficacy, which presents great potential for future clinical translations.
Mesoporous Silica-Encapsulated Gold Nanorods for Drug Delivery/Release and Two-Photon Excitation Fluorescence Imaging to Guide Synergistic Phototherapy and Chemotherapy
Publisher: American Chemical Society (ACS)
Date: 21-04-2023
Metal-free polycycloaddition of aldehyde-activated internal diynes and diazides toward post-functionalizable poly(formyl-1,2,3-triazole)s
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0PY00193G
Abstract: A metal-free polycycloaddition of aldehyde-activated internal diynes and diazides was successfully established and post-functionalizable poly(formyl-1,2,3-triazole)s were readily produced.
Integration of AIEgens into Covalent Organic Frameworks for Pyroptosis and Ferroptosis Primed Cancer Immunotherapy
Publisher: Research Square Platform LLC
Date: 31-03-2023
DOI: 10.21203/RS.3.RS-2690391/V1
Abstract: We report the construction of covalent organic framework (COF-919) from planar and twisted AIEgens-based motifs as a pyroptosis and ferroptosis dual-inducer that can elicit strong inflammatory response for efficient antitumor immunity. Mechanistic studies revealed that, in contrast to traditional COFs constructed with solely planar or twisted motifs, COF-919 displays stronger near-infrared light absorption, lower band energy and longer lifetime to favor the reactive oxygen species (ROS) generation and photothermal conversion for trigger pyroptosis. Because of its outstanding ROS production capability, intracellular lipid peroxidation was also upregulated to lead to glutathione depletion, glutathione peroxidase 4 low expression, and the induction of ferroptosis. Moreover, COF-919 induced pyroptosis and ferroptosis can effectively reshape the tumor immune microenvironment (TME) via promote T cells infiltration and relieve immunosuppressed TME to boost a T-cell-mediated immune response, which is favorable for inhibiting tumor metastasis and recurrence, with 99% tumor growth inhibition and 80% cure rates.
Aggregation‐Induced Emission Luminogens: Union Is Strength, Gathering Illuminates Healthcare
Publisher: Wiley
Date: 03-07-2018
Abstract: The rapid development of healthcare techniques encourages the emergence of new molecular imaging agents and modalities. Fluorescence imaging that enables precise monitoring and detection of biological processes/diseases is extensively investigated as this imaging technique has strengths in terms of high sensitivity, excellent temporal resolution, low cost, and good safety. Aggregation-induced emission luminogens (AIEgens) have recently emerged as a new class of emitters that possess several notable features, such as high brightness, large Stokes shift, marked photostability, good biocompatibility, and so on. So far, AIEgens are widely explored and exhibit superb performance in the area of biomedicine and life sciences. Herein, this review summarizes and discusses the recent investigations of AIEgens for in vivo diagnosis and therapy including long-term tracking, 3D angiography, multimodality imaging, disease theranostics, and activatable sensing. Collectively, these results reveal that AIEgens are of great promise for in vivo biomedical applications. It is hoped that this review will lead to new insights into the development of advanced healthcare materials.
“One Stone, Four Birds” Ion Engineering to Fabricate Versatile Core–Shell Organosilica Nanoparticles for Intelligent Nanotheranostics
Publisher: American Chemical Society (ACS)
Date: 02-06-2022
Abstract: Developing effective intelligent nanotheranostics is highly desirable for cancer treatment but remains challenging. In this study, an acidic tumor microenvironment-activated organosilica nanosystem, namely AD-Cu-DOX-HA, is straightforwardly constructed, which is composed of aggregation-induced emission (AIE)-active photosensitizer, copper ion-engineered aminosilica, direct coordination polymer of doxorubicin (DOX), and targeting component hyaluronic acid (HA). AD-Cu-DOX-HA is able to accurately distinguish cancer cells over normal cells meanwhile, it simultaneously exhibits selective accumulation and copper ion-mediated rapid disassembly and turn-on fluorescence in tumor tissue, consequently achieving efficient tumor diagnosis and tumor-growth inhibition through fluorescence imaging-navigated synergetic photodynamic therapy, copper ion-mediated chemodynamic therapy, and DOX-enabled chemotherapy. This work thus brings fresh insight into the exploration of versatile theranostics and presents a momentous advance for potential clinical cancer treatment.
State-of-the-art self-luminescence: a win–win situation
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2CS00228K
Abstract: The working principles, luminescent mechanisms, versatile integrated approaches and advantages, and future perspectives of AIE-assisted “enhanced” self-luminescence systems are reviewed.
A New Strategy toward “Simple” Water‐Soluble AIE Probes for Hypoxia Detection
Publisher: Wiley
Date: 19-06-2019
Aggregation-Induced Emission Luminogen with Near-Infrared-II Excitation and Near-Infrared-I Emission for Ultradeep Intravital Two-Photon Microscopy
Publisher: American Chemical Society (ACS)
Date: 30-07-2018
Abstract: Currently, a serious problem obstructing the large-scale clinical applications of fluorescence technique is the shallow penetration depth. Two-photon fluorescence microscopic imaging with excitation in the longer-wavelength near-infrared (NIR) region (>1100 nm) and emission in the NIR-I region (650-950 nm) is a good choice to realize deep-tissue and high-resolution imaging. Here, we report ultradeep two-photon fluorescence bioimaging with 1300 nm NIR-II excitation and NIR-I emission (peak ∼810 nm) based on a NIR aggregation-induced emission luminogen (AIEgen). The crab-shaped AIEgen possesses a planar core structure and several twisting phenyl/naphthyl rotators, affording both high fluorescence quantum yield and efficient two-photon activity. The organic AIE dots show high stability, good biocompatibility, and a large two-photon absorption cross section of 1.22 × 10
Water‐Soluble Organic Nanoparticles with Programable Intermolecular Charge Transfer for NIR‐II Photothermal Anti‐Bacterial Therapy
Publisher: Wiley
Date: 16-04-2021
Abstract: Extensive recent efforts have been put on the design of high‐performance organic near‐infrared (NIR) photothermal agents (PTAs), especially over NIR‐II bio‐window (1000–1350 nm). So far, the development is mainly limited by the rarity of molecules with good NIR‐II response. Here, we report organic nanoparticles of intermolecular charge‐transfer complexes (CTCs) with easily programmable optical absorption. By employing different common donor and acceptor molecules to form CTC nanoparticles (CT NPs), absorption peaks of CT NPs can be controllably tuned from the NIR‐I to NIR‐II region. Notably, CT NPs formed with perylene and TCNQ have a considerably red‐shifted absorption peak at 1040 nm and achieves a good photothermal conversion efficiency of 42 % under 1064 nm excitation. These nanoparticles were used for antibacterial application with effective activity towards both Gram‐negative and Gram‐positive bacteria. This work opens a new avenue into the development of efficient PTAs.
Visualizing and monitoring interface structures and dynamics by luminogens with aggregation-induced emission
Publisher: AIP Publishing
Date: 08-2019
DOI: 10.1063/1.5110688
Abstract: Interfaces exist in almost all objects and processes. Investigation on the interface not only is fundamentally important but also has great application prospects. Traditionally, the interface structure is studied by electron microscopy, which cannot reflect its real structure considering the pretreated process before measurement. Monitoring the interface evolution process by these regular methods is time-consuming and unfeasible in many cases. In this perspective article, we discuss how to realize the visualizing and monitoring interface structures and dynamics by aggregation-induced emission technique, which is applicable to almost all kinds of interfaces, including gas-solid, liquid-solid, solid-solid, gas-liquid-solid, and liquid-liquid-solid. Meanwhile, it is anticipated that the circularly polarized luminescence property in prochiral aggregation-induced emission luminogens can make a great difference in this area.
Achieving Tunable Organic Afterglow and UV‐Irradiation‐Responsive Ultralong Room‐Temperature Phosphorescence from Pyridine‐Substituted Triphenylamine Derivatives
Publisher: Wiley
Date: 30-05-2023
Abstract: Amorphous polymers with ultralong room‐temperature phosphorescence (RTP) are highly promising for various applications. Particularly, polymer‐based RTP materials with multiple functions such as color‐tunability or stimulus‐response are highly desirable for multilevel anti‐counterfeiting but are rarely reported. Herein, a facile strategy is presented to achieve a series of polymer‐based RTP materials with ultralong lifetime, multicolor afterglow, and reversible response to UV irradiation by simply embedding pyridine‐substituted triphenylamine derivatives into the polymer matrix poly(vinyl alcohol) (PVA) and poly(methyl methacrylate) (PMMA), respectively. Notably, the pyridine group with the capabilities of promoting intersystem crossing and forming hydrogen‐bonding interactions is essential for triggering ultralong RTP from the doping PVA system, among which the doping film TPA‐2Py@PVA exhibits excellent RTP property with an ultralong lifetime of 798.4 ms and a high quantum yield of 15.2%. By further co‐doping with the commercially available fluorescent dye, multicolor afterglow is obtained via phosphorescence energy transfer. Meanwhile, the doped PMMA system exhibits reversible photoactivated ultralong RTP properties under continuous UV irradiation. Finally, potential applications of these doped PVA and PMMA systems with ultralong lifetime, multicolor afterglow, and photoactivated ultralong RTP in multidimensional anti‐counterfeiting are demonstrated.
One stone, three birds: one AIEgen with three colors for fast differentiation of three pathogens
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0SC00256A
Abstract: A simple AIEgen with three emission colors achieves rapid identification of Gram-negative bacteria, Gram-positive bacteria and fungi.
Stereoisomeric Engineering of Aggregation-Induced Emission Photosensitizers towards Fungal Killing
Publisher: Research Square Platform LLC
Date: 09-06-2022
DOI: 10.21203/RS.3.RS-1688722/V1
Abstract: The human health crisis caused by fungal infection is impending. Photodynamic therapy (PDT) as an alternative antifungal approach has garnered much interest due to its minimal side effects and negligible antifungal drug resistance. Herein, we develop stereoisomeric photosensitizers ((Z)- and (E)-TPE-EPy) by harnessing different spatial configurations of one molecule. They possess aggregation-induced emission characteristics and ROS, viz. 1O2 and O2−• generation capabilities that enable image-guided PDT. Also, the cationization of the photosensitizers realizes targeting of fungal mitochondria for antifungal PDT killing. Particularly, stereoisomeric engineering assisted by supramolecular assembly leads to enhanced fluorescence intensity and ROS generation efficiency of the stereoisomers due to the excited state energy flow from nonradiative decay to the fluorescence pathway and intersystem (ISC) process. As a result, the supramolecular assemblies based on (Z)- and (E)-TPE-EPy show dramatically lowered dark toxicity without sacrificing their significant phototoxicity in the photodynamic antifungal experiments. This study is the first demonstration of stereoisomeric engineering of aggregation-induced emission photosensitizers based on (Z)- and (E)-configurations.
Design of Smart Aggregates: Toward Rapid Clinical Diagnosis of Hyperlipidemia in Human Blood
Publisher: Wiley
Date: 31-10-2022
Abstract: Molecular aggregates with environmental responsive properties are desired for their wide practical applications such as bioprobes. Here, a series of smart near‐infrared (NIR) luminogens for hyperlipidemia (HLP) diagnosis is reported. The aggregates of these molecules exhibit a twisted intramolecular charge‐transfer effect in aqueous media, but aggregation‐induced emission in highly viscous media due to the restriction of the intramolecular motion. These aggregates, which can autonomously respond to different environments via switching the aggregation state without changing their chemical structures are described, as “smart aggregates”. Intriguingly, these luminogens demonstrate NIR‐II and NIR‐III luminescence with ultralarge Stokes shifts ( nm). Both in vitro detection and in vivo imaging of HLP can be realized in a mouse model. Linear relationships exist between the emission intensity and multiple pathological parameters in blood s les of HLP patients. Thus, the design of smart aggregate facilitates rapid and accurate detection of HLP and provides a promising attempt in aggregate science.
In Situ Monitoring of RAFT Polymerization by Tetraphenylethylene‐Containing Agents with Aggregation‐Induced Emission Characteristics
Publisher: Wiley
Date: 23-04-2018
Abstract: A facile and efficient approach is demonstrated to visualize the polymerization in situ. A group of tetraphenylethylene (TPE)‐containing dithiocarbamates were synthesized and screened as agents for reversible addition fragmentation chain transfer (RAFT) polymerizations. The spatial‐temporal control characteristics of photochemistry enabled the RAFT polymerizations to be ON and OFF on demand under alternating visible light irradiation. The emission of TPE is sensitive to the local viscosity change owing to its aggregation‐induced emission characteristic. Quantitative information could be easily acquired by the naked eye without destroying the reaction system. Furthermore, the versatility of such a technique was well demonstrated by 12 different polymerization systems. The present approach thus demonstrated a powerful platform for understanding the controlled living radical polymerization process.
Aggregation-Induced Emission Luminogen-Based Direct Visualization of Concentration Gradient Inside an Evaporating Binary Sessile Droplet
Publisher: American Chemical Society (ACS)
Date: 15-08-2017
Abstract: In this study, the concentration gradient inside evaporating binary sessile droplets of 30, 50, and 60 vol % tetrahydrofuran (THF)/water mixtures was investigated. The 5 μL THF/water droplets were evaporated on a transparent hydrophobic substrate. This is the first demonstration of local concentration mapping within an evaporating binary droplet utilizing the aggregation-induced emission material. During the first two evaporation stages of the binary droplet, the local concentration can be directly visualized by the change of fluorescence emission intensity. Time-resolved average and local concentrations can be estimated by using the pre-established function of fluorescence intensity versus water volume fraction.
Aggregate Materials beyond AIEgens
Publisher: American Chemical Society (ACS)
Date: 05-11-2021
Single-Molecular Near-Infrared-II Theranostic Systems: Ultrastable Aggregation-Induced Emission Nanoparticles for Long-Term Tracing and Efficient Photothermal Therapy
Publisher: American Chemical Society (ACS)
Date: 11-10-2018
Abstract: Second near-infrared (NIR-II, 1000-1700 nm) fluorescence bioimaging has attracted tremendous scientific interest and already been used in many biomedical studies. However, reports on organic NIR-II fluorescent probes for in vivo photoinduced imaging and simultaneous therapy, as well as the long-term tracing of specific biological objects, are still very rare. Herein we designed a single-molecular and NIR-II-emissive theranostic system by encapsulating a kind of aggregation-induced emission luminogen (AIEgen, named BPN-BBTD) with hiphilic polymer. The ultra-stable BPN-BBTD nanoparticles were employed for the NIR-II fluorescence imaging and photothermal therapy of bladder tumors in vivo. The 785 nm excitation triggered photothermal therapy could completely eradicate the subcutaneous tumor and inhibit the growth of orthotopic tumors. Furthermore, BPN-BBTD nanoparticles were capable of monitoring subcutaneous and orthotopic tumors for a long time (32 days). Single-molecular and NIR-II-emitted aggregation-induced emission nanoparticles hold potential for the diagnosis, precise treatment, and metastasis monitoring of tumors in the future.
A versatile AIE fluorogen with selective reactivity to primary amines for monitoring amination, protein labeling, and mitochondrial staining
Publisher: Wiley
Date: 07-06-2022
DOI: 10.1002/AGT2.239
Abstract: Specific bioconjugation for native primary amines is highly valuable for both chemistry and biomedical research. Despite all the efforts, scientists lack a proper strategy to achieve high selectivity for primary amines, not to mention the requirement of fast response in real applications. Herein, we report a chromone‐based aggregation‐induced emission (AIE) fluorogen called CMVMN as a self‐reporting bioconjugation reagent for selective primary amine identification, and its applications for monitoring bioprocesses of amination and protein labeling. CMVMN is AIE‐active and capable of solid‐state sensing. Thus, its electrospun films are manufactured for visualization of amine diffusion and leakage process. CMVMN also shows good biocompatibility and potential mitochondria‐staining ability, which provides new insight for organelle‐staining probe design. Combined with its facile synthesis and good reversibility, CMVMN would not only show wide potential applications in biology, but also offer new possibilities for molecular engineering.
Diagnosis of fatty liver disease by a multiphoton-active and lipid-droplet-specific AIEgen with nonaromatic rotors
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0QM00877J
Abstract: We present a two-photon AIEgen, ABCXF with nonaromatic rotors (–CF 3 ), a high two-photon absorption cross-section, bright red emission in the solid-state, and remarkably high photostability for fatty liver disease diagnosis.
Visualization and monitoring of dynamic damaging–healing processes of polymers by using AIEgen-loaded multifunctional microcapsules
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2TA02918A
Abstract: The damaging–healing processes of multifunctional polymer coatings with self-healing capability, photoprotection properties, and water-proof functions are clearly visualized and monitored using AIEgen-loaded multifunctional microcapsules.
Benchmark and parameter tuning of hybrid functionals for fast calculation of excitation energies of AIEgens
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0CP02704A
Abstract: We did an investigation of 16 popular hybrid functionals in excitation energy simulations by time-dependent density functional theory over a benchmark based on the experimental results of aggregation-induced emission luminogens built using a consistent methodology.
Highly Efficient Blue Organic Light Emitting Diodes Based on Cyclohexane-Fused Quinoxaline Acceptor
Publisher: American Chemical Society (ACS)
Date: 31-07-2023
Principles of Aggregation‐Induced Emission: Design of Deactivation Pathways for Advanced AIEgens and Applications
Publisher: Wiley
Date: 18-05-2020
Good Steel Used in the Blade: Well‐Tailored Type‐I Photosensitizers with Aggregation‐Induced Emission Characteristics for Precise Nuclear Targeting Photodynamic Therapy
Publisher: Wiley
Date: 21-05-2021
Abstract: Photodynamic therapy (PDT) has long been recognized to be a promising approach for cancer treatment. However, the high oxygen dependency of conventional PDT dramatically impairs its overall therapeutic efficacy, especially in hypoxic solid tumors. Exploration of distinctive PDT strategy involving both high‐performance less‐oxygen‐dependent photosensitizers (PSs) and prominent drug delivery system is an appealing yet significantly challenging task. Herein, a precise nuclear targeting PDT protocol based on type‐I PSs with aggregation‐induced emission (AIE) characteristics is fabricated for the first time. Of the two synthesized AIE PSs, TTFMN is demonstrated to exhibit superior AIE property and stronger type‐I reactive oxygen species (ROS) generation efficiency owing to the introduction of tetraphenylethylene and smaller singlet–triplet energy gap, respectively. With the aid of a lysosomal acid‐activated TAT‐peptide‐modified hiphilic polymer poly(lactic acid)12k–poly(ethylene glycol)5k–succinic anhydride‐modified TAT, the corresponding TTFMN‐loaded nanoparticles accompanied with acid‐triggered nuclear targeting peculiarity can quickly accumulate in the tumor site, effectively generate type‐I ROS in the nuclear region and significantly suppress the tumor growth under white light irradiation with minimized systematic toxicity. This delicate “Good Steel Used in the Blade” tactic significantly maximizes the PDT efficacy and offers a conceptual while practical paradigm for optimized cancer treatment in further translational medicine.
Aggregation‐Induced Emission‐Active Gels: Fabrications, Functions, and Applications
Publisher: Wiley
Date: 03-07-2021
Abstract: Chromophores that exhibit aggregation‐induced emission (i.e., aggregation‐induced emission luminogens [AIEgens]) emit intense fluorescence in their aggregated states, but show negligible emission as discrete molecular species in solution due to the changes in restriction and freedom of intramolecular motions. As solvent‐swollen quasi‐solids with both a compact phase and a free space, gels enable manipulation of intramolecular motions. Thus, AIE‐active gels have attracted significant interest owing to their various distinctive properties and promising application potential. Herein, a comprehensive overview of AIE‐active gels is provided. The fabrication strategies employed are detailed, and the applications of AIEgens are summarized. In addition, the gel functions arising from the AIE moieties are revealed, along with their structure–property relationships. Furthermore, the applications of AIE‐active gels in erse areas are illustrated. Finally, ongoing challenges and potential means to address them are discussed, along with future perspectives on AIE‐active gels, with the overall aim of inspiring research on novel materials and ideas.
Aliphatic Polyesters with White-Light Clusteroluminescence
Publisher: American Chemical Society (ACS)
Date: 07-07-2022
DOI: 10.1021/JACS.2C05948
Abstract: Single-molecule white-light emission (SMWLE) has many advantages in practical applications however, the fabrication of SMWLE from nonconjugated luminescent polymers, namely, clusteroluminogens (CLgens), is still a big challenge. Herein, the first ex le of linear nonconjugated polyesters with SMWLE is reported. Twenty-four kinds of nonconjugated aliphatic polyesters with tunable clusteroluminescence (CL) colors and efficiency were synthesized by the copolymerization of six epoxides and four anhydrides. Experimental and calculation results prove that, at the primary structure level, the balance of structural flexibility and rigidity via adjusting the side-chain length significantly enhances the efficiency of CL without wavelength change. However, altering the chemical structures of the monomer from succinic anhydride to
Multicolor Tunable Polymeric Nanoparticle from the Tetraphenylethylene Cage for Temperature Sensing in Living Cells
Publisher: American Chemical Society (ACS)
Date: 12-12-2020
DOI: 10.1021/JACS.9B11544
Abstract: It is meaningful but challenging to develop a fluorescent probe for temperature sensing in living cells because it should possess the features of good cytocompatibility, easy read out, and high resolution. Herein, we successfully synthesized emissive star-like cage-based organic temperature-sensitive polymers that can assemble into nanoparticles in aqueous solution. The obtained nanoparticle can be easily tuned to full-color emission (including white light emission) with a temperature resolution of at least 0.5 °C by encapsulating different doses of guest dyes ((4-dimethylamino-2'-butoxychalcone (DMBC) and Nile Red (NR)) through a cascade Förster resonance energy transfer (FRET) effect. Moreover, the white light emission polymeric hybrid nanoparticles exhibit reversible stimuli response toward temperature and can be used as probes for temperature sensing in live cells through their fluorescent color variation between white and orange emission with good cytocompatibility.
Facile Synthesis of Red/NIR AIE Luminogens with Simple Structures, Bright Emissions, and High Photostabilities, and Their Applications for Specific Imaging of Lipid Droplets and Image‐Guided Photodyna
Publisher: Wiley
Date: 11-10-2017
In Situ Monitoring of RAFT Polymerization by Tetraphenylethylene‐Containing Agents with Aggregation‐Induced Emission Characteristics
Publisher: Wiley
Date: 23-04-2018
Abstract: A facile and efficient approach is demonstrated to visualize the polymerization in situ. A group of tetraphenylethylene (TPE)‐containing dithiocarbamates were synthesized and screened as agents for reversible addition fragmentation chain transfer (RAFT) polymerizations. The spatial‐temporal control characteristics of photochemistry enabled the RAFT polymerizations to be ON and OFF on demand under alternating visible light irradiation. The emission of TPE is sensitive to the local viscosity change owing to its aggregation‐induced emission characteristic. Quantitative information could be easily acquired by the naked eye without destroying the reaction system. Furthermore, the versatility of such a technique was well demonstrated by 12 different polymerization systems. The present approach thus demonstrated a powerful platform for understanding the controlled living radical polymerization process.
Solvent and Surface/Interface Effect on the Hierarchical Assemblies of Chiral Aggregation-Induced Emitting Molecules
Publisher: American Chemical Society (ACS)
Date: 15-02-2019
DOI: 10.1021/ACS.LANGMUIR.8B03358
Abstract: The core of aggregation-induced emitting (AIE) molecules was their aggregation behavior. It was, in essence, a self-assembly process driven by noncovalent interactions, which were governed not only by the chemical structures of the molecules but also by the conditions where the self-assemblies were formed. The self-assemblies of two AIE molecules, tetraphenylethene (TPE) derivatives carrying one valine attachment (TPE-Val) and two valine attachments (TPE-2Val), were studied. Both kinds of molecules self-assembled into supramolecular helical fibers with different handedness upon the addition of poor solvent to their solution. However, when deposited on air/water interface, both kinds of molecules formed aligned elementary helical fibers instead of supramolecular fibers. The lateral solvophobic effect exerted by water molecules caused a shift of the original noncovalent balance between molecules and solvent thus, the supramolecular helical assemblies were unraveled into aligned helical elementary fibers. Similar elementary assemblies were formed on the surface of 3-aminopropyl triethoxysilane-modified mica, confirming the lateral solvophobic effect on the self-assemblies of the molecules.
Conjugated Polymers with Aggregation‐Induced Emission Characteristics for Fluorescence Imaging and Photodynamic Therapy
Publisher: Wiley
Date: 10-05-2021
Abstract: Accurate diagnosis and treatment have been extensively developed in the field of biomedicine, which put forward higher requirements for the development of biomedical materials with high efficiency and selectivity. Among them, conjugated polymers featuring aggregation‐induced emission (AIE) characteristics (AIE conjugated polymers) have stood out in recent years owing to their unique properties, such as intense solid emission, high light‐harvesting ability, efficient energy transfer, and high 1 O 2 generation ability, which empower them with effective biomedical functions in fluorescence imaging (FLI), photodynamic therapy (PDT), FLI‐guided PDT, two‐photon excited photodynamic therapy (2PE‐PDT), etc . In this review, we highlight recent progress in AIE conjugated polymers and their applications in anticancer and antibacterial areas based on FLI and PDT, and summarize the mechanism of color‐tuned fluorescence emission and efficient 1 O 2 generation ability. The challenges and perspectives for the future development of AIE conjugated polymers are also discussed.
Ultrasensitive point-of-care biochemical sensor based on metal-AIEgen frameworks
Publisher: American Association for the Advancement of Science (AAAS)
Date: 29-07-2022
Abstract: Point-of-care (POC) biochemical sensors have found broad applications in areas ranging from clinical diagnosis to environmental monitoring. However, POC sensors often suffer from poor sensitivity. Here, we synthesized a metal-organic framework, where the ligand is the aggregation-induced emission luminogen (AIEgen), which we call metal-AIEgen frameworks (MAFs), for use in the ultrasensitive POC biochemical sensors. MAFs process a unique luminescent mechanism of structural rigidity-enhanced emission to achieve a high quantum yield (~99.9%). We optimized the MAFs to show 10 2 - to 10 3 -fold enhanced sensitivity for a hydrogel-based POC digital sensor and lateral flow immunoassays (LFIA). MAFs have a high affinity to directly absorb proteins, which can label antibodies for immunoassays. MAFs-based LFIA with enhanced sensitivity shows robust serum detection for POC clinical diagnosis.
Single Component Polymerization of Diisocyanoacetates toward Polyimidazoles
Publisher: American Chemical Society (ACS)
Date: 20-07-2018
An Air-Stable Organic Radical from a Controllable Photoinduced Domino Reaction of a Hexa-aryl Substituted Anthracene
Publisher: American Chemical Society (ACS)
Date: 25-05-2021
Dual-Color Emissive AIEgen for Specific and Label-Free Double-Stranded DNA Recognition and Single-Nucleotide Polymorphisms Detection
Publisher: American Chemical Society (ACS)
Date: 13-11-2019
DOI: 10.1021/JACS.9B09239
Abstract: Simple, rapid, and sensitive assays of DNA sequence hold great importance in genetic analysis, clinical diagnosis, and molecular biology research. Most current methods for DNA detection, based on the complementary base pairing, require hybridization with intricately modified single-stranded DNA (ssDNA) probes or analytes. Herein, we have developed a powerful molecule with aggregation-induced emission (AIE) characteristic, namely, TPBT, which can specifically recognize double-stranded DNA (dsDNA) by emitting out a unique dual-color fluorescent signal of red (∼640 nm) and green (∼537 nm). The red-color emission at around 640 nm is observed when TPBT binds with dsDNA, ssDNA, proteins, and other polyanionic analytes. However, the green emission at around 537 nm is demonstrated to be the exclusive response of TPBT to dsDNA, which is closely related to the conformational change of TPBT upon groove binding. More strikingly, TPBT can distinguish single-nucleotide polymorphisms (SNPs) in a dsDNA sequence and detect the DNA damage suffered from UV light with ultrahigh sensitivity and specificity. This label-free, AIEgen-based dsDNA assay method is facile, robust, and universal, which will lead to major advances in genomic and disease diagnosis.
Selenium‐Containing Type‐I Organic Photosensitizers with Dual Reactive Oxygen Species of Superoxide and Hydroxyl Radicals as Switch‐Hitter for Photodynamic Therapy
Publisher: Wiley
Date: 25-06-2023
Abstract: Organic type‐I photosensitizers (PSs) which produce aggressive reactive oxygen species (ROS) with less oxygen‐dependent exhibit attractive curative effect for photodynamic therapy (PDT), as they adapt better to hypoxia microenvironment in tumors. However, the reported type‐I PSs are limited and its exacted mechanism of oxygen dependence is still unclear. Herein, new selenium‐containing type‐I PSs of Se6 and Se5 with benzoselenadiazole acceptor has been designed and possessed aggregation‐induced emission characteristic. Benefited from double heavy‐atom‐effect of selenium and bromine, Se6 shows a smaller energy gap (Δ E ST ) of 0.03 eV and improves ROS efficiency. Interestingly, type‐I radicals of both long‐lived superoxide anion (O 2 •‾ ) and short‐lived hydroxyl ( • OH) are generated from them upon irradiation. This may provide a switch‐hitter of dual‐radical with complementary lifetimes for PDT. More importantly, simultaneous processes to produce • OH are revealed, including disproportionation of O 2 •‾ and reaction between excited PS and water. Actually, Se6 displays superior in–vitro PDT performance to commercial chlorin e6 (Ce6), under normoxia or hypoxia. After intravenous injection, a significantly in–vivo PDT performance is demonstrated on Se6, where tumor growth inhibition rates of 99% is higher than Ce6. These findings offer new insights about both molecular design and mechanism study of type‐I PSs.
Highly efficient and persistent room temperature phosphorescence from cluster exciton enables ultrasensitive off-on VOC sensing
Publisher: Elsevier BV
Date: 10-2022
An efficient aggregation‐enhanced delayed fluorescence luminogen created with spiro donors and carbonyl acceptor for applications as an emitter and sensitizer in high‐performance organic light‐emitting diodes
Publisher: Wiley
Date: 02-06-2023
DOI: 10.1002/AGT2.244
Abstract: Organic light‐emitting diodes (OLEDs) fabricated using organic thermally activated delayed fluorescence materials as sensitizers have recently achieved significant advancements, but the serious efficiency roll‐offs are still troublesome in most cases. Herein, a tailor‐made multifunctional luminogen SBF‐BP‐SFAC containing 9,9′‐spirobifluorene (SBF) and spiro[acridine‐9,9‐fluorene] (SFAC) as electron donors and carbonyl as an electron acceptor is synthesized and characterized. SBF‐BP‐SFAC has the advantages of high thermal stability, aggregation‐enhanced delayed fluorescence, and balanced carrier transport ability, and prefers horizontal dipole orientation. Highly efficient OLEDs employing SBF‐BP‐SFAC as an emitter radiate intense cyan light with outstanding external quantum efficiencies ( η ext s) of up to 30.6%. SBF‐BP‐SFAC can also serve as an excellent sensitizer for orange fluorescence, phosphorescence, and delayed fluorescence materials, providing excellent η ext s of up to 30.3% with very small efficiency roll‐offs due to the fast Förster energy transfer as well as exciton annihilation suppression by bulky spiro donors. These outstanding performances demonstrate the great potential of SBF‐BP‐SFAC as an emitter and sensitizer for OLEDs.
Translational Research: Bridging the Gap between Fundamental Research and the Clinic
Publisher: American Chemical Society (ACS)
Date: 05-12-2019
Combining Hydroxyl-Yne and Thiol-Ene Click Reactions to Facilely Access Sequence-Defined Macromolecules for High-Density Data Storage
Publisher: American Chemical Society (ACS)
Date: 28-12-2021
DOI: 10.1021/JACS.1C10612
Abstract: Through mimicking the synthesis of hereditary-information-containing nucleic acids, scientists are committed to synthesizing sequence-defined macromolecules. Herein, a protecting-group-free, metal-free, and atom-economical chemistry combining hydroxyl-yne and thiol-ene click reactions was developed to efficiently synthesize sequence-defined oligo(monothioacetals) (overall yield of 54% for an 11-step synthesis) from readily available starting compounds and monomers under ambient conditions. The sequences of linear oligo(monothioacetals) could be easily decoded via a tandem ESI-MS/MS technique, making them new kinds of digital macromolecules with a high data storage density (0.013 bit/Da). Moreover, star oligo(monothioacetals) could also be facilely generated through ergent and convergent strategies and their combination. An unprecedented sequence-defined miktoarm star oligo(monothioacetal) was obtained, which could serve as a new nonlinear digital macromolecule to achieve 2D information matrix encoding and hold great potential to be applied for information encryption, anticouterfeiting, secret communication, etc. Thus, this work provides a powerful stepwise iterative approach to facilely access sequence-defined linear and topological oligo(monothioacetals) for high-density data storage.
Luminescent MOFs constructed by using butterfly-like AIE ligands
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D2DT03382H
Abstract: A series of butterfly-like isomers named oxacalix[2]naphthalene[2]pyrazine (ONP) were conveniently synthesized by a one-step catalyst-free reaction in a facile manner, and they exhibit typical characteristics of aggregation-induced emission (AIE).
Dual fluorescence of tetraphenylethylene-substituted pyrenes with aggregation-induced emission characteristics for white-light emission
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8SC01709C
Abstract: This article presents a new strategy to achieve white-light emission from single tetraphenylethylene-substituted pyrenes (TPE-Pys) with aggregation-induced emission (AIE) characteristics.
Enantioselective recognition of chiral acids by supramolecular interactions with chiral AIEgens
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1CC05618B
Abstract: Chiral AIEgens enantioselectively discriminated a series of chiral acidic compounds and amino acids by supramolecular assembly.
Persistent organic room temperature phosphorescence: what is the role of molecular dimers?
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9SC04632A
Abstract: The first purely organic room temperature phosphorescence (RTP) luminogen, with singlet excimer emission and thermally activated delayed fluorescence (TADF) effect, was successfully developed.
Through-Space Interactions in Clusteroluminescence
Publisher: American Chemical Society (ACS)
Date: 30-09-2021
Supramolecular Polymerization with Dynamic Self-Sorting Sequence Control
Publisher: American Chemical Society (ACS)
Date: 12-11-2019
Solution‐processed AIEgen NIR OLEDs with EQE Approaching 15 %
Publisher: Wiley
Date: 28-04-2022
Abstract: Organic near‐infrared (NIR) luminogens have attracted intensive attention considering their vast potential applications in areas like bioimaging, organic light‐emitting diodes (OLEDs) and night‐vision telecommunication. However, organic NIR luminogens with high solid quantum efficiencies are scarce, limiting their applications. Here, we reported an electron‐deficient acceptor, BSM, based on dithiafulvalene and benzothiadiazole, which could work as a strong acceptor to produce highly efficient NIR emitters with aggregation‐induced emission (AIE) property. One of the AIEgens, TBSMCN emitted at 820 nm with a solid quantum yield of 10.7 %. When applied to solution‐processed OLEDs, an outstanding external quantum efficiency (EQE) of 9.4 % was achieved with a peak wavelength at 728 nm. Moreover, its non‐doped device could achieve an extraordinary EQE of 2.2 % peaking at 804 nm. In the further optimized configuration, when an extra sensitizer was added to harvest triplet excitons, the EQE unprecedentedly soared up to 14.3 % with a peak wavelength of 750 nm.
AIEgens for dark through-bond energy transfer: design, synthesis, theoretical study and application in ratiometric Hg2+ sensing
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6SC04206F
Abstract: A novel dark through-bond energy transfer (DTBET) strategy is proposed and applied as the design strategy to develop ratiometric Hg 2+ sensors with high performance.
Integration of AIEgens into covalent organic frameworks for pyroptosis and ferroptosis primed cancer immunotherapy
Publisher: Springer Science and Business Media LLC
Date: 02-09-2023
Copper-based ionic liquid-catalyzed click polymerization of diazides and diynes toward functional polytriazoles for sensing applications
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9PY01443H
Abstract: An efficient copper-based ionic liquid-catalyzed azide–alkyne click polymerization was developed, and functional polytriazoles were produced which could be used as sensors.
A smart AIEgen-functionalized surface with reversible modulation of fluorescence and wettability
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9MH00798A
Abstract: An AIEgen-functionalized surface with tunable fluorescence and wettability is obtained by taking advantage of anion–π + interactions.
Stiff and tough PDMS-MMT layered nanocomposites visualized by AIE luminogens
Publisher: Springer Science and Business Media LLC
Date: 27-07-2021
DOI: 10.1038/S41467-021-24835-W
Abstract: Polydimethylsiloxane (PDMS) is a widely used soft material that exhibits excellent stability and transparency. But the difficulty of fine-tuning its Young’s modulus and its low toughness significantly hinder its application in fields such as tissue engineering and flexible devices. Inspired by nacre, here we report on the development of PDMS-montmorillonite layered (PDMS-MMT-L) nanocomposites via the ice-templating technique, resulting in 23 and 12 times improvement in Young’s modulus and toughness as compared with pure PDMS. Confocal fluorescence microscopy assisted by aggregation-induced emission (AIE) luminogens reveals three-dimensional reconstruction and in situ crack tracing of the nacre-inspired PDMS-MMT-L nanocomposite. The PDMS-MMT-L nanocomposite is toughened with mechanisms such as crack deflection and bridging. The AIE-assisted visualization of the crack propagation for nacre-inspired layered nanocomposites provides an advanced and universal characterization technique for organic-inorganic nanocomposites.
Molecular Engineering of High-Performance Aggregation-Induced Emission Photosensitizers to Boost Cancer Theranostics Mediated by Acid-Triggered Nucleus-Targeted Nanovectors
Publisher: American Chemical Society (ACS)
Date: 02-06-2202
Multifunctional Fluorescent Main-Chain Charged Polyelectrolytes Synthesized by Cascade C–H Activation/Annulation Polymerizations
Publisher: American Chemical Society (ACS)
Date: 10-02-2023
DOI: 10.1021/JACS.2C12654
Aggregation-induced emission luminogen-based fluorescence detection of hypoxanthine: a probe for biomedical diagnosis of energy metabolism-related conditions
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TB00803E
Abstract: Highly sensitive and specific detection of hypoxanthine based on an aggregation-induced emission fluorescent probe is developed for energy metabolism-related diagnostics.
Neutrophil-like Biomimic AIE Nanoparticles with High-Efficiency Inflammatory Cytokine Targeting Enable Precise Photothermal Therapy and Alleviation of Inflammation
Publisher: American Chemical Society (ACS)
Date: 03-04-2023
A red-emissive antibody–AIEgen conjugate for turn-on and wash-free imaging of specific cancer cells
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7SC01054K
Abstract: For the first time, an AIEgen-conjugated monoclonal antibody is designed for “turn-on” and “wash-free” imaging of EGFR-overexpressed cancer cells.
Pillar[5]arene-based tunable luminescent materials via supramolecular assembly-induced Förster resonance energy transfer enhancement
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9QM00741E
Abstract: Supramolecular ensembles based on AIE-active pillararenes exhibit strongly enhanced emission accompanied with obvious colour changes upon assembly, where supramolecular assembly-induced enhanced emission and FRET process play key roles.
Keto-salicylaldehyde azine: asymmetric substituent effect on their optical properties via electron-donating group insertion
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9TC05822B
Abstract: Asymmetric substitution effect at K-terminal or S-terminal in KSA-based derivatives plays a key role in their AIE performance and metal ion responsiveness via simple intrinsic electronic structure tunings.
Regio- and Stereoselective Polymerization of Diynes with Inorganic Comonomer: A Facile Strategy to Conjugated Poly(p-arylene dihalodiene)s with Processability and Postfunctionalizability
Publisher: American Chemical Society (ACS)
Date: 27-04-2018
Antibacterial Theranostic Agents with Negligible Living Cell Invasiveness: AIE-Active Cationic Amphiphiles Regulated by Alkyl Chain Engineering
Publisher: American Chemical Society (ACS)
Date: 02-08-2022
Abstract: To address the threat of bacterial infection in the following post-antibiotic era, developing effective antibacterial approaches is of utmost urgency. Theranostic medicine integrating diagnosis and therapy is a promising protocol to fight against pathogenic bacteria. But numerous reported antibacterial theranostic materials are disclosed to be trapped in the excessive invasiveness to living mammal cells, leading to false positives and possible biosafety risks. Herein, a series of cationic pyridinium-substituted phosphindole oxide derivatives featuring aggregation-induced emission are designed, and alkyl chain engineering is conducted to finely tune their hydrophobicity and investigate their bioaffinity preference for living mammal cells and pathogenic bacteria. Most importantly, an efficient theranostic agent (PyBu-PIO) is acquired that is free from living cell invasiveness with negligible cytotoxicity and yet holds a good affinity for Gram-positive bacteria, including drug-resistant strains, with a superior inactivating effect. Externally applying PyBu-PIO onto Gram-positive bacteria-infected skin wounds can achieve creditable imaging effects and successfully accelerate the healing processes with reliable biosafety. This work proposes living cell invasiveness as a criterion for antibacterial theranostic materials and provides important enlightenment for the design of antibacterial theranostic materials.
Tuning Push–Pull Electronic Effects of AIEgens to Boost the Theranostic Efficacy for Colon Cancer
Publisher: American Chemical Society (ACS)
Date: 06-2020
DOI: 10.1021/JACS.0C02434
Molecular Transmission: Visible and Rate-Controllable Photoreactivity and Synergy of Aggregation-Induced Emission and Host–Guest Assembly
Publisher: American Chemical Society (ACS)
Date: 14-01-2019
Molecular engineering of AIE luminogens for NIR-II/IIb bioimaging and surgical navigation of lymph nodes
Publisher: Elsevier BV
Date: 09-2022
Insights into Self-Assembly of Nonplanar Molecules with Aggregation-Induced Emission Characteristics
Publisher: American Chemical Society (ACS)
Date: 16-11-2202
Abstract: Utilizing nonplanar conjugated molecules as building blocks facilitates the development of self-assembly but is fundamentally challenging. To study the self-assembly behavior, we herein demonstrate the self-assembly process of a nonplanar conjugated molecule with aggregation-induced emission (AIE) feature from an isolated molecule to an irregular cluster to a well-defined vesicle driven by hiphiles. The superhigh aggregation-sensitive emission affords more precise and detailed information about the self-assembly process than traditional dyes. Meanwhile, the arrangements of the AIE-active molecule change from disordered to well-organized forms by reducing the twisted configuration during the transformation process, and the strong hydrophobicity of hiphiles is crucial for such configuration and morphology transformations. Owing to the thermophilic bacteria-mimetic membranes, the obtained vesicles exhibit a property of superhigh thermal stability. They also display promising light-harvesting applications. This work not only deciphers the self-assembly of AIE molecules but also provides a strategy for nonplanar molecules to build well-organized self-assemblies.
Sulfur Conversion to Multifunctional Poly(O-thiocarbamate)s through Multicomponent Polymerizations of Sulfur, Diols, and Diisocyanides
Publisher: American Chemical Society (ACS)
Date: 04-03-2021
DOI: 10.1021/JACS.1C00243
Exosome‐Mimetic Supramolecular Vesicles with Reversible and Controllable Fusion and Fission**
Publisher: Wiley
Date: 17-09-2020
Ultrafast and Noninvasive Long-Term Bioimaging with Highly Stable Red Aggregation-Induced Emission Nanoparticles
Publisher: American Chemical Society (ACS)
Date: 29-01-2019
DOI: 10.1021/ACS.ANALCHEM.8B05024
Abstract: Strongly red luminescent and water-soluble probes are very important for studying biological events and processes. Fluorescent nanoparticles (NPs) built from the aggregation-induced emission luminogen (AIEgen) and hipathic polymeric matrixes have been considered as promising candidates for bioimaging. However, AIE NPs with long-wavelength absorption suitable for in vivo application are still scarce. In this work, three AIE-active red-emissive BODIPY derivatives with long-wavelength absorption were rationally designed and synthesized. Then three NPs based on these AIEgens exhibit bright red photoluminescence with high fluorescence quantum yield in aqueous media. These NPs uniformly dispersed in water and showed excellent stability and good biocompatibility. They can be readily internalized by HeLa cells, and the staining process is performed by simply shaking the culture with cells for just a few seconds at room temperature, which indicates an ultrafast and easy-to-operate staining protocol. More importantly, long-term tracing in living cells and mouse over 15 days is successfully achieved. The strong fluorescence signals, ultrafast staining procedure, and long-term tracing abilities indicate that these AIE NPs hold great potential for monitoring biological processes.
“Living” luminogens: light driven ACQ-to-AIE transformation accompanied with solid-state actuation
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0MH00447B
Abstract: In situ ACQ-to-AIE transformation was achieved by light-induced [2+2] cycloaddition via through-space conjugation.
De Novo Designed Self-Assembling Rhodamine Probe for Real-Time, Long-Term and Quantitative Live-Cell Nanoscopy
Publisher: American Chemical Society (ACS)
Date: 06-02-2023
Aggregation-Induced Emission Luminogens as Color Converters for Visible-Light Communication
Publisher: American Chemical Society (ACS)
Date: 11-09-2018
Abstract: In this work, we report the application of the aggregation-induced emission luminogens (AIEgens) as color converters for visible light communication (VLC). In the form of pure solid powder, the AIEgens studied herein have demonstrated blue-to-red full-color emissions, large -6 dB electrical modulation bandwidths up to 279 MHz (∼56× that of commercial phosphor), and most of them can achieve high data rates of 428-493 Mbps (up to ∼49× that of commercial phosphor) at a maximum bit error rate of 3.8 × 10
Aggregate Science: From Structures to Properties
Publisher: Wiley
Date: 30-07-2020
Biomimetic Nanoplatform Loading Type I Aggregation-Induced Emission Photosensitizer and Glutamine Blockade to Regulate Nutrient Partitioning for Enhancing Antitumor Immunotherapy
Publisher: American Chemical Society (ACS)
Date: 13-07-2022
Abstract: The intense metabolism of cancer cells leads to hypoxia and lack of crucial nutrients in the tumor microenvironment, which hinders the function of immune cells. We designed a biomimetic immune metabolic nanoplatform, in which a type I aggregation-induced emission photosensitizer and a glutamine antagonist are encapsulated into a cancer cell membrane for achieving specific delivery
Phototriggered Aggregation‐Induced Emission and Direct Generation of 4D Soft Patterns
Publisher: Wiley
Date: 04-10-2021
Abstract: Microscopic control of macroscopic phenomena is one of the core subjects in materials science. Particularly, the spatio‐temporal control of material behaviors through a non‐contact way is of fundamental importance but is difficult to accomplish. Herein, a strategy to realize remote spatio‐temporal control of luminescence behaviors is reported. A multi‐arm salicylaldehyde benzoylhydrazone‐based aggregation‐induced emission luminogen (AIEgen)/metal‐ion system, of which the fluorescence can be gated by the UV irradiation with time dependency, is developed. By changing the metal‐ion species, the fluorescence emission and the intensity can also be tuned. The mechanism of the UV‐mediated fluorescence change is investigated, and it is revealed that a phototriggered aggregation‐induced emission (PTAIE) process contributes to the behaviors. The AIEgen is further covalently integrated into a polymeric network and the formed gel/metal‐ion system can achieve laser‐mediated mask‐free writing enabled by the PTAIE process. Moreover, by further taking advantage of the time‐dependent self‐healing property of hydrazone‐based dynamic covalent bond, transformable 4D soft patterns are generated. The findings and the strategy increase the ways to manipulate molecules on the supramolecule or aggregate level. They also show opportunities for the development of controllable smart materials and expand the scope of the materials in advanced optoelectronic applications.
The odd–even effect of alkyl chain in organic room temperature phosphorescence luminogens and the corresponding in vivo imaging
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9QM00108E
Abstract: Six alkyl substituted phenothiazine 5,5-dioxide derivatives, containing groups from methyl to hexyl groups, were synthesized, and demonstrated an apparent odd–even effect in RTP lifetime never observed before.
Facile Synthesis of Functional Processable Fluoropolydienes by Alkyne-Based Multicomponent Polycouplings
Publisher: American Chemical Society (ACS)
Date: 16-11-2020
Metal‐Based Aggregation‐Induced Emission Theranostic Systems
Publisher: Wiley
Date: 04-12-2022
Abstract: Efficient theranostic systems can realize better outcomes in disease treatment because of precise diagnosis and the concomitant effective therapy. Aggregation‐induced emission luminogens (AIEgens) are a unique type of organic emitters with intriguing photophysical properties in the aggregate state. Among the AIEgens studied for biomedical applications, so far, metal‐based AIE systems have shown great potential in theranostics due to the enhanced multimodal bioimaging ability and therapeutic effect. This research field has been growing rapidly, and many rationally designed systems with promising activities to cancer and other diseases have been reported recently. In this review, we summarized the recent progress of metal‐based AIE materials in bioimaging and biological theranostics, and deciphered the pertinent design strategies. We hope that this review can offer new insights into the development of this growing field.
Generating circularly polarized luminescence from clusterization‐triggered emission using solid phase molecular self-assembly
Publisher: Springer Science and Business Media LLC
Date: 17-09-2021
DOI: 10.1038/S41467-021-25789-9
Abstract: Purely-organic clusterization‐triggered emission (CTE) has displayed promising abilities in bioimaging, chemical sensing, and multicolor luminescence. However, it remains absent in the field of circularly polarized luminescence (CPL) due to the difficulties in well-aligning the nonconventional luminogens. We report a case of CPL generated with CTE using the solid phase molecular self-assembly (SPMSA) of poly-L-lysine (PLL) and oleate ion (OL), that is, the macroscopic CPL supramolecular film self-assembled by the electrostatic complex of PLL/OL under mechanical pressure. Well-defined interface charge distribution, given by lamellar mesophases of OL ions, forces the PLL chains to fold regularly as a requirement of optimal electrostatic interactions. Further facilitated by hydrogen bonding, the through-space conjugation (TSC) of orderly aligned electron-rich O and N atoms leads to CTE-based CPL, which is capable of transferring energy to an acceptor via a Förster resonance energy transfer (FRET) process, making it possible to develop environmentally friendly and economic CPL from sustainable and renewable materials.
Fluorescence Turn-On Visualization of Microscopic Processes for Self-Healing Gels by AIEgens and Anticounterfeiting Application
Publisher: American Chemical Society (ACS)
Date: 12-07-2019
Efficient Near-Infrared Photosensitizer with Aggregation-Induced Emission for Imaging-Guided Photodynamic Therapy in Multiple Xenograft Tumor Models
Publisher: American Chemical Society (ACS)
Date: 10-12-2019
Abstract: Photodynamic therapy (PDT) strategy has been widely used in tumor treatment, and the reagents for reactive oxygen species (ROS) play a crucial role. Herein, we develop a fluorogen (TTB) containing an electron-accepting benzo[1,2-
Integrating Anion−π+ Interaction and Crowded Conformation to Develop Multifunctional NIR AIEgen for Effective Tumor Theranostics via Hippo–YAP Pathway
Publisher: American Chemical Society (ACS)
Date: 30-10-2023
Luminescent two-way reversible shape memory polymers prepared by hydroxyl–yne click polymerization
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0TC03888A
Abstract: Luminescent two-way reversible shape memory polymers that could be fabricated into robotic grippers and realize double anti-counterfeiting are prepared via an organobase-catalyzed hydroxyl–yne click polymerization under mild reaction conditions.
Through-Space Conjugation: An Effective Strategy for Stabilizing Intramolecular Charge-Transfer States
Publisher: American Chemical Society (ACS)
Date: 03-05-2019
DOI: 10.1021/ACS.JPCLETT.9B01040
Abstract: Intramolecular charge transfer (ICT) has significant impacts on organic optoelectronic materials, photochemistry, biotechnology, and so on. However, it is hard to stabilize the ICT state because of the rapid nonradiative charge recombination process, which often quenches light emission. In this work, we use new foldamers of the protonated pyridine-modified tetraphenylethene derivatives that possess through-space conjugation (TSC) characters as the models to study the impact of TSC on the ICT state. Steady and transient spectroscopies illustrate that the lifetime of the ICT state in the molecule with strong TSC can be much longer than those of molecules without TSC, giving rise to a higher fluorescence quantum yield. By combining the theoretical calculations, we demonstrate that the strong TSC can stabilize the ICT state and slow the charge recombination rate by more efficiently dispersing charges. This is a conceptually new design strategy for functional optoelectronic materials that require more stable ICT states.
Excited-State Odd–Even Effect in Through-Space Interactions
Publisher: American Chemical Society (ACS)
Date: 15-09-2023
DOI: 10.1021/JACS.3C08164
Multifunctional AIE Nanosphere-Based “Nanobomb” for Trimodal Imaging-Guided Photothermal/Photodynamic/Pharmacological Therapy of Drug-Resistant Bacterial Infections
Publisher: American Chemical Society (ACS)
Date: 24-02-2023
Fluorescent Sensor Array for Highly Efficient Microbial Lysate Identification through Competitive Interactions
Publisher: American Chemical Society (ACS)
Date: 23-10-2018
DOI: 10.1021/ACSSENSORS.8B00650
Abstract: Optical cross-reactive sensor arrays have recently been proven to be a powerful tool for high-throughput bioanalytes identification. Nevertheless, identification and classification of microbes, especially using microbial lysates as the analytes, still is a great challenge due to their complex composition. Herein, we achieve this goal by using luminogens featuring aggregation-induced emission characteristics (AIEgens) and graphene oxide (GO) to construct a microbial lysate responsive fluorescent sensor array. The combination of AIEgen with GO not only reduces the background signal but also induces the competition interactions among AIEgen, microbial lysates, and GO, which highly improves the discrimination ability of the sensor array. As a result, six microbes, including two fungi, two Gram-positive bacteria, and two Gram-negative bacteria are precisely identified. Thus, this work provides a new way to design safer and simpler sensor arrays for the discrimination of complex analytes.
Biomimetic Aggregation‐Induced Emission Nanodots with Hitchhiking Function for T Cell‐Mediated Cancer Targeting and NIR‐II Fluorescence‐Guided Mild‐Temperature Photothermal Therapy
Publisher: Wiley
Date: 03-08-2022
Abstract: Photothermal therapy (PTT) holds potential as an alternative approach for effective cancer treatment since it exerts minimal side effects on normal tissues. However, the photothermal stimulation increases the expression of heat shock protein (HSP) in tumor cells, rendering the tumor cells insensitive to heat and thus constraining the effects of PTT. In this study, biomimetic aggregation‐induced emission (AIE) photothermal agents with hitchhiking ability (DC@BPBBT dots) are developed by coating the nanoaggregates of the NIR AIE polymeric photothermal agents with dendritic cell (DC) membranes. Notably, the inner nanoaggregate (BPBBT dots) holds bright second‐window near infrared (NIR‐II) fluorescence (quantum yield of up to 3.47%) and a high photothermal conversion performance (photothermal conversion efficiency of up to 30.5%), and the outer cell membrane can facilitate the hitchhiking of DC@BPBBT dots on endogenous T cells and enhance the tumor delivery efficiency by about 1.2 times. Furthermore, DC@BPBBT dots can activate and stimulate T cells in vivo to secrete cytokine tumor necrosis factor α (TNF‐α), which can reduce the expression of heat shock protein 70 (HSP70) to render tumor cells more sensitive to heat. This study not only provides an alternative heat shock protein inhibition strategy based on immune cell interactions but also provides a hitchhike approach for drug delivery in cancer photothermal immunotherapy.
Accelerating multielectron reduction at CuxO nanograins interfaces with controlled local electric field
Publisher: Research Square Platform LLC
Date: 24-10-2023
Restriction of Access to the Dark State: A New Mechanistic Model for Heteroatom‐Containing AIE Systems
Publisher: Wiley
Date: 27-08-2019
Abstract: Restriction of intramolecular motion (RIM), as the working mechanism of aggregation-induced emission (AIE), cannot fully explain some heteroatom-containing systems. Now, two excited states are taken into account and a mechanism, restriction of access to dark state (RADS), is specified to elaborate RIM and complete the picture of AIE mechanism. A nitrogen-containing molecule named APA is chosen as a model compound its weak fluorescence in solution is ascribed to the easy access from the bright (π,π*) state to the close-lying dark (n,π*) state. By either metal complexation or aggregation, the dark state is less accessible due to restriction of the molecular motion leading to the dark state and elevation of the dark state energy, thus the bright state emission is restored. RADS is powerful in elucidating the AIE effect of molecules with excited states favoring non-radiative decay, including overlap-forbidden states such as (n,π*) and CT states, spin-forbidden triplet states, and so on.
Information‐Storage Expansion Enabled by a Resilient Aggregation‐Induced‐Emission‐Active Nanocomposite Hydrogel
Publisher: Wiley
Date: 26-10-2022
Abstract: Advanced materials with high performance and distinctive function are one of the main driving forces for the development of human society. The selection of appropriate materials and adequately utilizing their features to apply them in a specific area rationally are of great significance but remain challenging. Herein, an aggregation‐induced emission (AIE)‐active nanocomposite (NC) hydrogel is developed by introducing a pH‐responsive AIE luminogen (AIEgen) into a Laponite XLS olyacrylamide‐based NC hydrogel (Laponite is a trademark of the company BYK Additives Ltd.). The AIEgen can protonate to interact with the negatively charged clay through the electrostatic interaction, which results in a drastic fluorescence enhancement due to the restriction of intramolecular motion by the rigid clay to the protonated AIEgen. This behavior facilitates the input of fluorescent information with a high contrast ratio in the hydrogel by acid stimulation. Moreover, by utilizing the excellent resilience of the hydrogel, hierarchically inputting and displaying the information in the original and stretched states of the hydrogel film is realized, which achieves information‐storage expansion and dual‐encryption via switching between stretching and restoring the film. This work showcases fully and synergistically utilizing the superiorities of various advanced materials to achieve superior applications and should guide the future development of advanced materials in emerging areas.
Endowing TADF Luminophors with AIE Properties Though Adjusting Flexible Dendrons for Highly Efficient Solution-Processed Nondoped OLEDs.
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
DOI: 10.26434/CHEMRXIV.12152520.V1
Abstract: The amalgamation of thermally activated delayed fluorescence (TADF) and aggregation-induced emission (AIE) properties, term AIE-TADF, is a promising strategy to design novel robust luminescent materials. Herein, we transform 2,3,4,5,6-penta(9H-carbazol-9-yl)benzonitrile (5CzBN) from an ACQ molecule to AIEgens by simply decorating a 5CzBN core with alkyl chain-linked spirobifluorene dendrons. By increasing the number of flexible dendrons, these materials can not only show obvious AIE-TADF characteristics and uniform film morphology, but also exhibit better resistance to isopropyl alcohol, which are beneficial to the fully solution-processed OLEDs. Notably, 5CzBN-PSP show great device efficiency with external quantum efficiency (EQE), current efficiency and power efficiency of 20.1%, 58.7 cd A -1 and 46.2 lm W -1 , respectively, which achieved record-breaking efficiency in solution-processed nondoped OLEDs based on AIE emitters. It demonstrates a general approach to explore new efficient emitters by the marriage of AIE and TADF what could potentially improve their performance in various areas.
Construction of Covalent Organic Cages with Aggregation‐Induced Emission Characteristics from Metallacages for Mimicking Light‐Harvesting Antenna
Publisher: Wiley
Date: 28-07-2023
Abstract: A series of covalent organic cages built from fluorophores capable of aggregation‐induced emission (AIE) were elegantly prepared through the reduction of preorganized M 2 (L A ) 3 (L B ) 2 ‐type metallacages, simultaneously taking advantage of the synthetic accessibility and well‐defined shapes and sizes of metallacages, the good chemical stability of the covalent cages as well as the bright emission of AIE fluorophores. Moreover, the covalent cages could be further post‐synthetically modified into an amide‐functionalized cage with a higher quantum yield. Furthermore, these presented covalent cages proved to be good energy donors and were used to construct light‐harvesting systems employing Nile Red as an energy acceptor. These light‐harvesting systems displayed efficient energy transfer and relatively high antenna effect, which enabled their use as efficient photocatalysts for a dehalogenation reaction. This research provides a new avenue for the development of luminescent covalent cages for light‐harvesting and photocatalysis.
Visualization of Enantiorecognition and Resolution by Chiral AIEgens
Publisher: American Chemical Society (ACS)
Date: 11-05-2022
Abstract: Enantioselective recognition and separation have attracted much attention in pharmaceutical analysis, food chemistry, and life science. Herein, we propose an efficient strategy to achieve such purposes using optically active luminogens with aggregation-induced emission (AIE) characteristics. These AIE luminogens (AIEgens) show strong enantiomeric discrimination for 12 kinds of chiral acids and unprotected amino acids. In particular, an exceptionally high enantioselectivity for d/l-Boc-glutamic acid was observed, as demonstrated by the large difference between the formed AIEgen/acid complexes. Due to the AIE effect, enantioselective separation was achieved by aggregation of the AIEgens with one enantiomer in the mixed acid solution. Through analysis of the fluorescence standard curve, the aggregates of AIEgen/chiral acid possessed 90% d-analyte, from which the enantiomeric excess (ee) value was assessed to be 80% ee. Such a result is in good agreement with that (91% d-analyte and 82% ee) by chiral HPLC analysis. Thus, this simple one-step aggregation method can serve as a preliminary screening tool for high-throughput analysis or separation of chiral chemicals.
Precise Molecular Engineering of Type I Photosensitizers with Near‐Infrared Aggregation‐Induced Emission for Image‐Guided Photodynamic Killing of Multidrug‐Resistant Bacteria
Publisher: Wiley
Date: 19-12-2021
Abstract: Multidrug resistance (MDR) bacteria pose a serious threat to human health. The development of alternative treatment modalities and therapeutic agents for treating MDR bacteria‐caused infections remains a global challenge. Herein, a series of near‐infrared (NIR) anion– π + photosensitizers featuring aggregation‐induced emission (AIE‐PSs) are rationally designed and successfully developed for broad‐spectrum MDR bacteria eradication. Due to the strong intramolecular charge transfer (ICT) and enhanced highly efficient intersystem crossing (ISC), these electron‐rich anion– π + AIE‐PSs show boosted type I reactive oxygen species (ROS) generation capability involving hydroxyl radicals and superoxide anion radicals, and up to 99% photodynamic killing efficacy is achieved for both Methicillin‐resistant Staphylococcus aureus (MRSA) and multidrug resistant Escherichia coli (MDR E. coli ) under a low dose white light irradiation (16 mW cm −2 ). In vivo experiments confirm that one of these AIE‐PSs exhibit excellent therapeutic performance in curing MRSA or MDR E. coli ‐infected wounds with negligible side‐effects. The study would thus provide useful guidance for the rational design of high‐performance type I AIE‐PSs to overcome antibiotic resistance.
A ratiometric fluorescent probe based on AIEgen for detecting HClO in living cells
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0CC06582J
Abstract: A high performance ratiometric fluorescent probe, namely TPE-RNS, has been developed for detecting exogenous and endogenous HClO/ClO − in living cells and discriminating cancer cells from normal cells.
Structure-tuned and thermodynamically controlled mechanochromic self-recovery of AIE-active Au(i ) complexes
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9TC06297A
Abstract: The flexible alkyl chain-tuned and temperature-dependent self-recovery behaviors aided by molecular motions in a series of AIE-active Au( i ) complexes was investigated.
Time‐Dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE‐Active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation
Publisher: Wiley
Date: 22-10-2019
Abstract: Pathogen infections and cancer are two major human health problems. Herein, we report the synthesis of an organic salt photosensitizer (PS), called 4TPA-BQ, by a one-step reaction. 4TPA-BQ presents aggregation-induced emission features. Owing to the aggregation-induced reactive oxygen species generated and a sufficiently small ΔE
Bright Near-Infrared Aggregation-Induced Emission Luminogens with Strong Two-Photon Absorption, Excellent Organelle Specificity, and Efficient Photodynamic Therapy Potential
Publisher: American Chemical Society (ACS)
Date: 03-08-2018
Abstract: Far-red and near-infrared (NIR) fluorescent materials possessing the characteristics of strong two-photon absorption and aggregation-induced emission (AIE) as well as specific targeting capability are much-sought-after for bioimaging and therapeutic applications due to their deep penetration depth and high resolution. Herein, a series of dipolar far-red and NIR AIE luminogens with a strong push-pull effect are designed and synthesized. The obtained fluorophores display bright far-red and NIR solid-state fluorescence with a high quantum yield of up to 30%, large Stokes shifts of up to 244 nm, and large two-photon absorption cross-sections of up to 887 GM. A total of three neutral AIEgens show specific lipid droplet (LD)-targeting capability, while the one with cationic and lipophilic characteristics tends to target the mitochondria specifically. All of the molecules demonstrate good biocompatibility, high brightness, and superior photostability. They also serve as efficient two-photon fluorescence-imaging agents for the clear visualization of LDs or mitochondria in living cells and tissues with deep tissue penetration (up to 150 μm) and high contrast. These AIEgens can efficiently generate singlet oxygen upon light irradiation for the photodynamic ablation of cancer cells. All of these intriguing results prove that these far-red and NIR AIEgens are excellent candidates for the two-photon fluorescence imaging of LDs or mitochondria and organelle-targeting photodynamic cancer therapy.
Aggregation Effect on Multiperformance Improvement in Aryl-Armed Phenazine-Based Emitters
Publisher: American Chemical Society (ACS)
Date: 05-01-2023
DOI: 10.1021/JACS.2C09210
Multifunctional Two-Photon AIE Luminogens for Highly Mitochondria-Specific Bioimaging and Efficient Photodynamic Therapy
Publisher: American Chemical Society (ACS)
Date: 30-05-2019
Abstract: In recent years, photodynamic therapy (PDT) has drawn much attention as a noninvasive and safe cancer therapy method due to its fine controllability, good selectivity, low systemic toxicity, and minimal drug resistance in contrast to the conventional methods (for ex le, chemotherapy, radiotherapy, and surgery). However, some drawbacks still remain for the current organic photosensitizers such as low singlet oxygen (
Aggregation-Induced Emission (AIE), Life and Health
Publisher: American Chemical Society (ACS)
Date: 24-07-2023
Mitochondria-Specific Aggregation-Induced Emission Luminogens for Selective Photodynamic Killing of Fungi and Efficacious Treatment of Keratitis
Publisher: American Chemical Society (ACS)
Date: 28-06-2021
Abstract: The development of effective antifungal agents remains a big challenge in view of the close evolutionary relationship between mammalian cells and fungi. Moreover, rapid mutations of fungal receptors at the molecular level result in the emergence of drug resistance. Here, with low tendency to develop drug-resistance, the subcellular organelle mitochondrion is exploited as an alternative target for efficient fungal killing by photodynamic therapy (PDT) of mitochondrial-targeting luminogens with aggregation-induced emission characteristics (AIEgens). With cationic isoquinolinium (IQ) moiety and proper hydrophobicity, three AIEgens, namely, IQ-TPE-2O, IQ-Cm, and IQ-TPA, can preferentially accumulate at the mitochondria of fungi over the mammalian cells. Upon white light irradiation, these AIEgens efficiently generate reactive 1 O 2 , which causes irreversible damage to fungal mitochondria and further triggers the fungal death. Among them, IQ-TPA shows the highest PDT efficiency against fungi and negligible toxicity to mammalian cells, achieving the selective and highly efficient killing of fungi. Furthermore, we tested the clinical utility of this PDT strategy by treating fungal keratitis on a fungus-infected rabbit model. It was demonstrated that IQ-TPA presents obviously better therapeutic effects as compared with the clinically used rose bengal, suggesting the success of this PDT strategy and its great potential for clinical treatment of fungal infections.
AIE Featured Inorganic–Organic Core@Shell Nanoparticles for High-Efficiency siRNA Delivery and Real-Time Monitoring
Publisher: American Chemical Society (ACS)
Date: 04-03-2019
DOI: 10.1021/ACS.NANOLETT.8B04677
Abstract: RNA interference (RNAi) is demonstrated as one of the most powerful technologies for sequence-specific suppression of genes in disease therapeutics. Exploration of novel vehicles for small interfering RNA (siRNA) delivery with high efficiency, low cytotoxicity, and self-monitoring functionality is persistently pursued. Herein, by taking advantage of aggregation-induced emission luminogen (AIEgen), we developed a novel class of Ag@AIE core@shell nanocarriers with regulable and uniform morphology. It presented excellent efficiencies in siRNA delivery, target gene knockdown, and cancer cell inhibition in vitro. What's more, an anticancer efficacy up to 75% was achieved in small animal experiments without obvious toxicity. Attributing to the unique AIE properties, real-time intracellular tracking of siRNA delivery and long-term tumor tissue imaging were successfully realized. Compared to the commercial transfection reagents, significant improvements were obtained in biocompatibility, delivery efficiency, and reproducibility, representing a promising future of this nanocarrier in RNAi-related cancer therapeutics.
Enlarging the Reservoir: High Absorption Coefficient Dyes Enable Synergetic Near Infrared‐II Fluorescence Imaging and Near Infrared‐I Photothermal Therapy
Publisher: Wiley
Date: 07-05-2021
Abstract: Although organic materials with near infrared (NIR)‐II fluorescence and a photothermal effect have been widely investigated for the accurate diagnosis and treatment of tumors, optimizing the output signals of both remain challenging. Here, a strategy by “enlarging absorption reservoir” to address this issue, since an increase in photon absorption can naturally enhance output signals, is proposed. As a proof‐of‐concept, a large π‐conjugated diketopyrrolopyrrole (DPP) unit is selected to fabricate strong light‐absorbing systems. To enhance solid‐state fluorescence, highly twisted alkylthiophene–benzobisthiadiazole–alkylthiophene and triphenylamine rotor are introduced to restrict the strong intermolecular π–π interactions. Moreover, the number of DPP units in molecules is engineered to optimize photophysical properties. Results show that TDADT with two DPP units possesses an exceptionally high molar absorptivity of 2.1 × 10 5 L mol −1 cm −1 at 808 nm, an acceptable NIR‐II quantum yield of 0.1% (emission peak at 1270 nm), and a sizeable photothermal conversion efficiency of 60.4%. The excellent photophysical properties of the TDADT nanoparticles are particularly suitable for in vivo NIR‐II imaging‐guided cancer surgery and NIR‐I photothermal therapy. The presented strategy provides a new approach of designing highly efficient NIR‐II phototheranostic agents.
Doping AIE Photothermal Molecule into All-Fiber Aerogel with Self-Pumping Water Function for Efficiency Solar Steam Generation
Publisher: American Chemical Society (ACS)
Date: 14-05-2020
Stimuli‐Responsive AIEgens
Publisher: Wiley
Date: 17-06-2021
Abstract: The unique advantages and the exciting application prospects of AIEgens have triggered booming developments in this area in recent years. Among them, stimuli‐responsive AIEgens have received particular attention and impressive progress, and they have been demonstrated to show tremendous potential in many fields from physical chemistry to materials science and to biology and medicine. Here, the recent achievements of stimuli‐responsive AIEgens in terms of seven most representative types of stimuli including force, light, polarity, temperature, electricity, ion, and pH, are summarized. Based on typical ex les, it is illustrated how each type of systems realize the desired stimuli‐responsive performance for various applications. The key work principles behind them are ultimately deciphered and figured out to offer new insights and guidelines for the design and engineering of the next‐generation stimuli‐responsive luminescent materials for more broad applications.
Multiple Stimuli Responses of Stereo-Isomers of AIE-Active Ethynylene-Bridged and Pyridyl-Modified Tetraphenylethene
Publisher: American Chemical Society (ACS)
Date: 08-02-2018
Abstract: Luminescent molecules with aggregation-induced emission (AIE) property or AIE-active luminogens (AIE-gens) are typical stimuli-responsive materials. Many AIE-gens have shown luminescent responses to mechano-, thermo-, electro-, vapo-, and/or solvato-stimulus, but the detailed structure-property relationship has been addressed for only a few of them. Here, we report a tetraphenylethene (TPE) derivative with pyridyl modifiers and ethynylene bridges. The (Z)- and (E)-isomers are clearly purified, and both of them are AIE-active and demonstrate multiple luminescent responses to external stimuli. Distinct from other reported TPE derivatives, the two isomers show negative solvatochromism due to the large dipole in the ground electronic state. By correlating with the single crystal structures, the subtle differences in quantum efficiency and emission peak wavelength of the solids of the (Z)- and (E)-isomers are rationally explained. Moreover, the ground powder of the (E)-isomer can recover its emission color from green to blue in the air at room temperature but the (Z)-isomer cannot. This difference is interpreted by a mechanism of water-triggered conformational variation, which depends on the hydrogen bond formation between pyridyl moieties and water molecules in the air. In addition to the reversible emission color changes by cyclic grinding-fuming treatments, both of the isomers exhibit a reversible luminescent response to acid-base treatments by switching the emission color between green (basic) and yellow (acid), owing to the incorporation of pyridyl units into the molecule. The unprecedented multiple stimuli-responsive behaviors and clear mechanism explanations allow this kind of AIE-gens to be promising smart materials.
Bringing Inherent Charges into Aggregation-Induced Emission Research
Publisher: American Chemical Society (ACS)
Date: 05-01-2022
DOI: 10.1021/ACS.ACCOUNTS.1C00630
Abstract: Charged organic molecules, such as DNA, RNA, proteins, and polysaccharides, are ubiquitous and indispensable in natural living systems, which possess specific biological functions to interact with oppositely charged species via electrostatic attraction. The molecules with inherent charges typically differentiate themselves from the neutral ones with unique attributes (e.g., ionic interactions and high polarity), thereby playing a pivotal role in a broad spectrum of areas, including supramolecular chemistry, structural biology, and materials science. It is thus of great importance to explore and develop various charged organic systems for biomimicry and the creation of functional materials. In 2001, our group reported a peculiar luminogen that exhibited weak emission in solution but had significantly enhanced emission in aggregates, and we, for the first time, coined this phenomenon as aggregation-induced emission (AIE). The AIE concept significantly changes the cognition of the scientific community toward classic photophysical phenomena. Since the discovery of this unusual luminescence phenomenon, AIE luminogens (AIEgens) have attracted extensive attention from researchers in a plethora of disciplines because of their high brightness in aggregates, large Stokes shift, excellent photostability, and good biocompatibility. In the past 10 years, our laboratory has expended a great amount of effort to bring inherent charges into AIE research and acquired fruitful achievements.In this Account, we summarize the progress of charged AIE systems primarily made by our laboratory. We start with a brief introduction to charged AIEgens and then discuss their design strategies from molecular and topological perspectives, respectively. Next, we review the unique properties of charged AIEgens, including D-A interactions, anion-π
Autonomous Visualization of Damage in Polymers by Metal‐Free Polymerizations of Microencapsulated Activated Alkynes
Publisher: Wiley
Date: 23-01-2022
Abstract: The development of autonomous materials with desired performance and built‐in visualizable sensing units is of great academic and industrial significance. Although a wide range of damage indication methods have been reported, the “turn‐on” sensing mechanism by damaging events based on microcapsule systems, especially those relying on chemical reactions to elicit a chromogenic response, are still very limited. Herein, a facile and metal‐free polymerization route with an interesting reaction‐induced coloration effect is demonstrated. Under the catalysis of 1,4‐diazabicyclo[2.2.2]octane (DABCO), the polymerizations of difunctional or trifunctional activated alkynes proceed very quickly at 0 °C in air. A series of polymers composed of stereoregular enyne structure (major unit) and inyl ether structure (minor unit) are obtained. Both the catalyst and monomers are colorless while the polymerized products are deep‐colored. This process can be applied for the damage visualization of polymers using the microencapsulation technique. Microcapsules containing the reactive alkyne monomer are prepared and mixed in a DABCO‐dispersed polymer film. Both the external and internal damage regions of this composite film can be readily visualized once the reaction is initiated from the ruptured microcapsules. Moreover, the newly formed polymer automatically seals the cracks with an additional protection function.
Boosting the efficiency of organic persistent room-temperature phosphorescence by intramolecular triplet-triplet energy transfer
Publisher: Springer Science and Business Media LLC
Date: 08-04-2019
DOI: 10.1038/S41467-019-09561-8
Abstract: Persistent luminescence is a fascinating phenomenon with exceptional applications. However, the development of organic materials capable of persistent luminescence, such as organic persistent room-temperature phosphorescence, lags behind for their normally low efficiency. Moreover, enhancing the phosphorescence efficiency of organic luminophores often results in short lifetime, which sets an irreconcilable obstacle. Here we report a strategy to boost the efficiency of phosphorescence by intramolecular triplet-triplet energy transfer. Incorpotation of (bromo)dibenzofuran or (bromo)dibenzothiophene to carbazole has boosted the intersystem crossing and provided an intramolecular triplet-state bridge to offer a near quantitative exothermic triplet–triplet energy transfer to repopulate the lowest triplet-state of carbazole. All these factors work together to contribute the efficient phosphorescence. The generation and transfer of triplet excitons within a single molecule is revealed by low-temperature spectra, energy level and lifetime investigations. The strategy developed here will enable the development of efficient phosphorescent materials for potential high-tech applications.
Innovative Synthetic Procedures for Luminogens Showing Aggregation‐Induced Emission
Publisher: Wiley
Date: 09-02-2021
Abstract: As a consequence of their intrinsic advantageous properties, luminogens that show aggregation‐induced emission (AIEgens) have received increasing global interest for a wide range of applications. Whereas general synthetic methods towards AIEgens largely rely on tedious procedures and limited reaction types, various innovative synthetic methods have now emerged as complementary, and even alternative, strategies. In this Review, we systematically highlight advancements made in metal‐catalyzed functionalization and metal‐free‐promoted pathways for the construction of AIEgens over the past five years, and briefly illustrate new perspectives in this area. The development of innovative synthetic procedures will enable the facile synthesis of AIEgens with great structural ersity for multifunctional applications.
Designing Efficient and Ultralong Pure Organic Room‐Temperature Phosphorescent Materials by Structural Isomerism
Publisher: Wiley
Date: 04-06-2018
Recent advances of aggregation-induced emission materials for fluorescence image-guided surgery
Publisher: Elsevier BV
Date: 09-2022
DOI: 10.1016/J.BIOMATERIALS.2022.121709
Abstract: Real-time intraoperative guidance is essential during various surgical treatment of many diseases. Aggregation-induced emission (AIE) materials have shown great potential for guiding surgeons during complex interventions, with the merits of deep tissue penetration, high quantum yield, high molar absorptivity, low background, good targeting ability and excellent photostability. Herein, we provided insights to design efficient AIE materials regarding three key parameters, i.e., deep-tissue penetration ability, high brightness of AIE luminogens (AIEgens), and precise tumor/other pathology nidus targeting strategies, for realizing better application of fluorescence image-guided surgery. Representative interdisciplinary achievements were outlined for the demonstration of this emerging field. Challenges and future opportunities of AIE materials were briefly discussed. The aim of this review is to provide a comprehensive view of AIE materials for intraoperative guidance for researchers and surgeons, and to inspire more further correlational studies in the new frontiers of image-guided surgery.
Hydrazone‐Based AIEgens with Photofluorochromic Ability for Rewritable, Intensity‐Variable, and High‐Resolution Photopattern
Publisher: Wiley
Date: 13-01-2023
Abstract: Photoswitches with multiple fluorescence states known as photofluorochromism upon photo‐induced isomerization show practical applications in information storage, anticounterfeiting, and sensors. However, it is still challenging to realize rapid isomerization, efficient fluorescence, and gradient signal output simultaneously. Herein, by incorporating luminogenic units with aggregation‐induced emission (AIE) features into photo‐responsive hydrazone, a series of novel photofluorochromic AIE compounds are developed. These newly designed compounds exhibit quantum yields of up to 38.4% and could undergo reversible and swift photo‐isomerization upon 450/365 nm irradiation. Accordingly, the fabricated photopatterns based on them are utilized as quantitatively described images for information storage, which show excellent rewritability and intensity‐variable fluorescence with a high resolution of 10 µm. This work provides a new strategy to develop intelligent photopattern systems with continuous gradient fluorescence for information storage and cybernetics.
Type I photosensitizers based on phosphindole oxide for photodynamic therapy: apoptosis and autophagy induced by endoplasmic reticulum stress
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0SC00785D
Abstract: Phosphindole oxide-based photosensitizers with Type I reactive oxygen species generation ability are developed and used for endoplasmic reticulum stress-mediated photodynamic therapy of tumors.
A Highly Sensitive Bimodal Detection of Amine Vapours Based on Aggregation Induced Emission of 1,2‐Dihydroquinoxaline Derivatives
Publisher: Wiley
Date: 25-09-2017
Abstract: The detection of food spoilage is a major concern in food safety as large amounts of food are transported globally. Direct analysis of food s les is often time-consuming and requires expensive analytical instrumentation. A much simpler and more cost-effective method for monitoring food fermentation is to detect biogenic amines generated as a by-product during food decomposition. In this work, a series of 1,2-dihydroquinoxaline derivatives (DQs) with aggregation-induced emission (AIE) characteristics were synthesised and their protonated forms, that is, H
A Bifunctional Aggregation‐Induced Emission Luminogen for Monitoring and Killing of Multidrug‐Resistant Bacteria
Publisher: Wiley
Date: 30-08-2018
Redox-responsive fluorescent AIE bioconjugate with aggregation enhanced retention features for targeted imaging reinforcement and selective suppression of cancer cells
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9QM00216B
Abstract: Redox-responsive fluorescent AIE bioconjugate with aggregation enhanced retention features for targeted imaging reinforcement and selective suppression of cancer cells.
Side Area‐Assisted 3D Evaporator with Antibiofouling Function for Ultra‐Efficient Solar Steam Generation
Publisher: Wiley
Date: 26-07-2021
Abstract: Solar‐driven interfacial steam generation (SISG) has been recognized as a promising strategy to solve water shortages in an eco‐friendly and low‐cost way. However, the practical application of SISG is vitally restricted by some inherent limits, especially for finite evaporation rate and insufficient working life of evaporator. Herein, a novel SISG system involving an all‐fiber porous cylinder‐like foam 3D evaporator, side area‐assisted evaporation protocol, and aggregation‐induced‐emission‐active solar absorber with “one stone two birds” function is explored. The solar absorber exhibits efficient photothermal conversion, endowing the side area‐assisted evaporator with as high as 3.6 kg m −2 h −1 of solar evaporation rate, which is highly desirable for SISG under 1 sun of irradiation. Moreover, the solar absorber is capable of powerfully producing reactive oxygen species upon sunlight irradiation, which results in extraordinary photodynamic killing of bacteria nearby the fiber to prevent biofouling, consequently improving the working life of evaporator.
Intra- and Intermolecular Synergistic Engineering of Aggregation-Induced Emission Luminogens to Boost Three-Photon Absorption for Through-Skull Brain Imaging
Publisher: American Chemical Society (ACS)
Date: 31-03-2022
Abstract: Three-photon fluorescence microscopic (3PFM) bioimaging is a promising imaging technique for visualizing the brain in its native environment thanks to its advantages of high spatial resolution and large imaging depth. However, developing fluorophores with strong three-photon absorption (3PA) and bright emission that meets the requirements for efficient three-photon fluorescence microscopic (3PFM) bioimaging is still challenging. Herein, four bright fluorophores with aggregation-induced emission features are facilely synthesized, and their powders exhibit high quantum yields of up to 56.4%. The intramolecular engineering of luminogens endows ( E )-2-(benzo[ d ]thiazol-2-yl)-3-(7-(diphenylamino)-9-ethyl-9 H -carbazol-2-yl)acrylonitrile (DCBT) molecules with bright near-infrared emission and large 3PA cross sections of up to 1.57 × 10 -78 cm 6 s 2 photon -2 at 1550 nm, which is boosted by 3.6-fold to 5.61 × 10 -78 cm 6 s 2 photon -2 in DCBT dots benefiting from the extensive intermolecular interactions in molecular stacking. DCBT dots are successfully applied for 3PFM imaging of brain vasculature on mice with a removed or intact skull, providing images with high spatial resolution, and even small capillaries can be recognized below the skull. This study will inspire more insights for developing advanced multiphoton absorbing materials for biomedical applications.
Molecular logic operations from complex coacervation with aggregation-induced emission characteristics
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2MH00537A
Abstract: Leveraging complex coacervation of a polycation and a bivalent anion with aggregation-induced emission characteristics, we accomplish eight basic logic operations, producing Boolean-like ‘outputs’ with contrast higher than one order of magnitude.
A Feasible Strategy of Fabricating Type I Photosensitizer for Photodynamic Therapy in Cancer Cells and Pathogens
Publisher: American Chemical Society (ACS)
Date: 15-04-2021
“Simple” Aggregation‐Induced Emission Luminogens for Nondoped Solution‐Processed Organic Light‐Emitting Diodes with Emission Close to Pure Red in the Standard Red, Green, and Blue Gamut
Publisher: Wiley
Date: 09-05-2021
Abstract: Development of simple and efficient red emissive luminogens is desirable yet challenging for optoelectronic devices due to the limited molecular design and the difficulties of synthesis. Red emitting molecules possess large π‐conjugated systems, which permit quenching in the solid state due to π–π stacking and are detrimental to the performance of devices. Furthermore, traditional red emitters usually exhibit emission far from pure red in the standard red, green, and blue (sRGB) gamut. Herein, two red luminogens, DCMa and DCIs, with aggregation‐induced emission (AIE) characteristics based on simple donor–acceptor (D–A) structures are explored. They show high fluorescence quantum yields (QYs) of 13.2% and 7.8% in the film state. Efficient nondoped solution‐processed organic light emitting diodes (OLEDs) with a configuration of indium tin oxide (ITO) oly(3,4‐ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) oly[(9,9‐dioctylfluorenyl‐2,7‐diyl)‐ co ‐(4,40‐( N ‐(4‐sec‐butylphenyl)diphenylamine)] (TFB)/DCMa or DCIs/(1,3,5‐tris(2‐ N ‐phenylbenzimidazolyl)benzene) (TPBi)/LiF/Al are fabricated, which emit red electroluminescence at 652 and 711 nm, respectively. Furthermore, they exhibit International Commission on Illumination (CIE) coordinates of (0.63, 0.36) and (0.64, 0.35), respectively, which are close to the value of the primary red color (0.63, 0.34) according to the digital television standard. These results of small molecules DCMa and DCIs suggest future methods for designing new red emitters for nondoped solution‐processed OLEDs.
Shape-Reconfigurable Ferrofluids
Publisher: American Chemical Society (ACS)
Date: 29-06-2022
DOI: 10.1021/ACS.NANOLETT.2C01721
Abstract: Ferrofluids (FFs) can adapt their shape to a magnetic field. However, they cannot maintain their shape when the magnetic field is removed. Here, with a magneto-responsive and reconfigurable interfacial self-assembly (MRRIS) process, we show that FFs can be structured by a magnetic field and maintain their shape, like solids, after removing the magnetic field. The competing self-assembly of magnetic and nonmagnetic nanoparticles at the liquid interface endow FFs with both reconfigurability and structural stability. By manipulating the external magnetic field, we show that it is possible to "write" and "erase" the shape of the FFs remotely and repeatedly. To gain an in-depth understanding of the effect of MRRIS on the structure of FFs, we systematically study the shape variation of these liquids under both the static and dynamic magnetic fields. Our study provides a simple yet novel way of manipulating FFs and opens opportunities for the fabrication of all-liquid devices.
Molecular Motion in the Solid State
Publisher: American Chemical Society (ACS)
Date: 27-08-2019
Functional Polymer Systems with Aggregation-Induced Emission and Stimuli Responses
Publisher: Springer Science and Business Media LLC
Date: 11-01-2010
Donor/π‐Bridge Manipulation for Constructing a Stable NIR‐II Aggregation‐Induced Emission Luminogen with Balanced Phototheranostic Performance**
Publisher: Wiley
Date: 16-11-2021
Abstract: Owing to their versatile functionality and tunable energy dissipation, aggregation‐induced emission luminogens (AIEgens) have emerged as a potential platform for multimodal theranostics. Nevertheless, the construction of AIE‐active phototheranostic agents in the second near‐infrared window (NIR‐II, 1000–1700 nm), which allows superior resolution and minimized photodamage, is still a formidable challenge. Herein, benzo[ c ]thiophene serves as an electron‐rich and bulky donor (D)/π‐bridge, which can enlarge the conjugation length and distort the backbone of an AIEgen. By precise D/π‐bridge engineering, highly stable NIR‐II AIEgen DPBTA‐DPTQ nanoparticles are obtained with acceptable NIR‐II fluorescence quantum yield and excellent photothermal conversion efficiency. In addition, the spatial conformation of DPBTA‐DPTQ is determined for the first time by X‐ray single crystal diffraction and theoretical simulations. DPBTA‐DPTQ NPs have good biocompatibility and show efficient photothermal therapeutic effects in in vitro tests. Furthermore, DPBTA‐DPTQ NPs were used in fluorescence‐photoacoustic‐photothermal trimodal imaging‐guided photothermal eradication of tumors in HepG2 and B16‐F10 tumor‐xenografted mice.
Acceptor Planarization and Donor Rotation: A Facile Strategy for Realizing Synergistic Cancer Phototherapy via Type I PDT and PTT
Publisher: American Chemical Society (ACS)
Date: 03-2022
Abstract: Tumor hypoxia seriously impairs the therapeutic outcomes of type II photodynamic therapy (PDT), which is highly dependent upon tissue oxygen concentration. Herein, a facile strategy of acceptor planarization and donor rotation is proposed to design type I photosensitizers (PSs) and photothermal reagents. Acceptor planarization can not only enforce intramolecular charge transfer to redshift NIR absorption but also transfer the type of PSs from type II to type I photochemical pathways. Donor rotation optimizes photothermal conversion efficiency (PCE). Accordingly, three 3,6- inyl-substituted diketopyrrolopyrrole (DPP) derivatives, 2TPAVDPP, TPATPEVDPP, and 2TPEVDPP, with different number of rotors were prepared. Experimental results showed that three compounds were excellent type I PSs, and the corresponding 2TPEVDPP nanoparticles (NPs) with the most rotors possessed the highest PCE. The photophysical properties of 2TPEVDPP NPs are particularly suitable for
Intermolecular Hydrogen-Bond-Assisted Solid-State Dual-Emission Molecules with Mechanical Force-Induced Enhanced Emission
Publisher: American Chemical Society (ACS)
Date: 21-06-2022
Abstract: Hydrogen bonds not only play a crucial role in the life sciences but also endow molecules with fantastic physical and chemical properties, which help in the realization of their high-tech applications. This work presents an efficient strategy for achieving highly efficient solid-state dual-emission blue emitters with mechanical force-induced enhanced emission properties via intermolecular hydrogen bonds via novel pyrene-based intermediates, namely, 1,3,6,8-tetrabromo-2,7-dihydroxypyrene (
Facile fabrication of self-shrinkable AIE supramolecular gels based on benzophenone salicylaldehyde hydrazine derivatives
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0TC03665J
Abstract: A novel molecular design strategy to give self-shrinkable AIE-active supramolecular gels with a variation in the morphology and an obvious emission enhancement via benzophenone salicylaldehyde hydrazine (BSH) derivatives was reported.
Aggregation-Induced Emission: A Trailblazing Journey to the Field of Biomedicine
Publisher: American Chemical Society (ACS)
Date: 30-10-2018
Double‐pronged Antimicrobial Agents based on a Donor‐π‐Acceptor Type Aggregation‐Induced Emission Luminogen
Publisher: Wiley
Date: 20-10-2022
Abstract: Novel antibacterial agents are urgently needed to control the infections induced by multidrug‐resistant (MDR) bacteria. Herein, we rationally designed and facilely synthesized a new D‐π‐A type luminogen with strong red/near‐infrared fluorescence emission, great aggregation‐induced emission (AIE) features, and excellent reactive oxygen species (ROS) production. The newly developed molecule TTTh killed the methicillin‐resistant Staphylococcus aureus (MRSA) by triggering the ROS accumulation in bacteria and interrupting the membrane integrity. Moreover, TTTh specifically targeted the lysosomes and potentiated their maturation to accelerate the clearance of intracellular bacteria. Additionally, reduced bacterial burden and improved healing were observed in TTTh‐treated wounds with negligible side effects. Our study expands the biological design and application of AIE luminogens (AIEgens), and provides new insights into discovering novel antibacterial targets and agents.
Hierarchical Supramolecular Self‐Assembly: Fabrication and Visualization of Multiblock Microstructures**
Publisher: Wiley
Date: 02-11-2022
Abstract: Due to the fast dynamics and re‐equilibration of supramolecular self‐assembly, bottom‐up molecular strategies to fabricate well‐defined and controllable multiblock structures are rare. Herein, we propose a new concept for fabrication of fluorescent multiblock microcolumns containing 1 to 7 blocks via hierarchical supramolecular self‐assembly based on cucurbit[8]uril (CB[8]), NaBr and an AIEgen guest. Through the complexation between CB[8] and different numbers of AIEgen guests (2, 1, 0), the competitive displacement caused by the binding of the sodium cation to the CB[8] portal, and the reversible assembly of positively charged guests in salt solutions, one‐pot hierarchical supramolecular self‐assembly is realized. The molecular structure of each block is analyzed by single‐crystal X‐ray diffraction. The AIEgen enables the self‐assembly of multiblocks to be visualized, understood, and regulated.
Feasible structure-modification strategy for inhibiting aggregation-caused quenching effect and constructing exciton conversion channels in acridone-based emitters
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9CP01706B
Abstract: The introduction of multiple rotors donors and benzonitrile group in ADOs would increases effectively OLED emitters' performance by inhibiting aggregation-caused quenching effect and constructing exciton conversion channels.
Pyrene-based blue emitters with aggregation-induced emission features for high-performance organic light-emitting diodes
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8TC05547E
Abstract: Non-doped organic light-emitting diodes (OLEDs) using pyrene-based AIE luminogens as emitters displayed sky-blue light at 492 nm at a low turn-on voltage (3.1 V) with a maximum luminance of 15 750 cd m −2 and a current efficiency of 7.34 cd A −1 with a low efficiency roll-off.
White-Light Emission of a Binary Light-Harvesting Platform Based on an Amphiphilic Organic Cage
Publisher: American Chemical Society (ACS)
Date: 08-02-2018
Progress in Isocyanide‐Based Step‐Growth Polymerization
Publisher: Wiley
Date: 07-12-2022
Abstract: Isocyanide is an important class of active synthon with a special electronic structure and abundant chemical properties, which can participate in various organic reactions and has a wide range of applications in the efficient synthesis of pharmaceutical molecules, heterocyclic compounds, and natural products, etc. With the development of chemical science, isocyanide‐based reactions have been gradually applied from the synthesis of low mass molecules to functional polymers. This review focuses on the recent progress in isocyanide‐based step‐growth polymerization, as well as the properties and applications of the resultant functional polymers. These polymerizations are ided into six main parts including Passerini polymerization, Ugi polymerization, multicomponent polymerization (MCP) of isocyanide and dialkylacetylenedicarboxylates (DAADs), MCP of isocyanide and green monomer, MCP of isocyanide and industrial waste, as well as the polymerization based on isocyanoacetate. The existing challenges and the promising opportunities are concisely discussed.
Unusual light-driven amplification through unexpected regioselective photogeneration of five-membered azaheterocyclic AIEgen
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0SC04725B
Abstract: A multifunctional, AIE-based, fused five-membered azaheterocycle is photogenerated with light-driven lification to combat the photobleaching issue and fabricate display materials.
Sugar-Based Aggregation-Induced Emission Luminogens: Design, Structures, and Applications
Publisher: American Chemical Society (ACS)
Date: 14-04-2020
Full-color-tunable AIE luminogens for 4D code, security patterns, and multicolor LEDs
Publisher: Elsevier BV
Date: 2023
Facile Polymerization of Water and Triple-Bond Based Monomers toward Functional Polyamides
Publisher: American Chemical Society (ACS)
Date: 18-10-2017
Highly Efficient Circularly Polarized Electroluminescence from Aggregation‐Induced Emission Luminogens with Amplified Chirality and Delayed Fluorescence
Publisher: Wiley
Date: 28-02-2018
Anthracene-based bipolar deep-blue emitters for efficient white OLEDs with ultra-high stabilities of emission color and efficiency
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1TC00432H
Abstract: High-performance two-color hybrid warm white OLEDs are fabricated using TPA-TAn-DMAC as blue emission layer, achieving ultra-high stabilities of EL efficiency and color at high luminance over 30 000 cd m −2 .
Multiple yet Controllable Photoswitching in a Single AIEgen System
Publisher: American Chemical Society (ACS)
Date: 27-01-2018
DOI: 10.1021/JACS.7B13364
Abstract: Seeking new methods to obtain elaborate artificial on-demand photoswitching with multiple functionalities remains challenging. Most of the systems reported so far possess only one specific function and their nonemissive nature in the aggregated state inevitably limit their applications. Herein, a tailored cyanostilbene-based molecule with aggregation-induced emission characteristic was synthesized and was found to exhibit efficient, multiple and controllable photoresponsive behaviors under different conditions. Specifically, three different reactions were involved: (i) reversible Z/E isomerization under room light and thermal treatment in CH
Modulation of the intramolecular hydrogen bonding and push–pull electron effects toward realizing highly efficient organic room temperature phosphorescence
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2TC01093C
Abstract: A facile design strategy based on the structural control of intramolecular hydrogen bonding and push–pull electron effects was proposed to construct highly efficient UORTP materials.
Structure–Property Relationship of Regioregular Polytriazoles Produced by Ligand-Controlled Regiodivergent Ru(II)-Catalyzed Azide–Alkyne Click Polymerization
Publisher: American Chemical Society (ACS)
Date: 22-02-2019
Making Aggregation-Induced Emission Luminogen More Valuable by Gold: Enhancing Anticancer Efficacy by Suppressing Thioredoxin Reductase Activity
Publisher: American Chemical Society (ACS)
Date: 03-05-2021
Abstract: Gold complexes have been recognized as potential anticancer agents against various kinds of diseases due to their inherent suppressions of antioxidant thioredoxin reductase (TrxR) activity. Herein, a powerful aggregation-induced emission luminogen (AIEgen), TBP-Au, was designed and synthesized by integrating an anticancer Au(I) moiety with an AIE-active photosensitizer (TBP), in which both the production and consumption routes of reactive oxygen species (ROS) were elaborately considered simultaneously to boost the anticancer efficacy. It has been demonstrated that TBP-Au could realize superior two-photon fluorescence imaging in tumor tissues with high resolution and deep penetration as well as long-term imaging in live animals due to its AIE property. In addition, the introduction of a special Au(I) moiety could tune the organelle specificity and efficiently facilitate the ROS-determined photodynamic therapy (PDT). More impressively, TBP-Au could efficiently eliminate cancer cells under light irradiation through the preconceived synergetic approaches from the PDT and the effective suppression of TrxR, demonstrating that TBP-Au holds great potential for precise cancer theranostics.
Engineering Sensor Arrays Using Aggregation‐Induced Emission Luminogens for Pathogen Identification
Publisher: Wiley
Date: 29-11-2018
Tetraphenylethene Cross-Linked Thermosensitive Microgels via Acylhydrazone Bonds: Aggregation-Induced Emission in Nanoconfined Environments and the Cononsolvency Effect
Publisher: American Chemical Society (ACS)
Date: 24-07-2018
Tuning Organelle Specificity and Photodynamic Therapy Efficiency by Molecular Function Design
Publisher: American Chemical Society (ACS)
Date: 17-09-2019
Abstract: Efficient organic photosensitizers (PSs) have attracted much attention because of their promising applications in photodynamic therapy (PDT). However, guidelines on their molecular design are rarely reported. In this work, a series of PSs are designed and synthesized based on a triphenylamine-azafluorenone core. Their structure-property-application relationships are systematically studied. Cationization is an effective strategy to enhance the PDT efficiency of PSs by targeting mitochondria. From the molecularly dispersed state to the aggregate state, the fluorescence and the reactive oxygen species generation efficiency of PSs with aggregation-induced emission (AIE) increase due to the restriction of the intramolecular motions and enhancement of intersystem crossing. Cationized mitochondrion-targeting PSs show higher PDT efficiency than that of nonionized ones targeting lipid droplets. The ability of AIE PSs to kill cancer cells can be further enhanced by combination of PDT with radiotherapy. Such results should trigger research enthusiasm for designing and synthesizing AIE PSs with better PDT efficiency and properties.
An organic microlaser based on an aggregation-induced emission fluorophore for tensile strain sensing
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1TC00323B
Abstract: An organic microlaser based on a kind of innovative AIE fluorophore TPA-BDTO was fabricated by self-assembly method, and could be used for axial tensile strain sensing with high sensitivity and high resolution.
Biological Synthesis and Process Monitoring of an Aggregation-Induced Emission Luminogen-Based Fluorescent Polymer
Publisher: American Chemical Society (ACS)
Date: 15-09-2022
Aggregation‐Induced Emission Luminogens Married to 2D Black Phosphorus Nanosheets for Highly Efficient Multimodal Theranostics
Publisher: Wiley
Date: 06-08-2020
Multistimuli Response and Polymorphism of a Novel Tetraphenylethylene Derivative
Publisher: Wiley
Date: 20-02-2019
Universal Bipolar Host Materials for Blue, Green, and Red Phosphorescent OLEDs with Excellent Efficiencies and Small-Efficiency Roll-Off
Publisher: American Chemical Society (ACS)
Date: 04-07-2019
Abstract: Host materials are indispensable for the fabrication of organic light-emitting diodes (OLEDs) with phosphorescent emitters, but high-quality host materials that can efficiently and simultaneously function in blue, green, and red phosphorescent OLEDs (PHOLEDs) are much rare. In this work, four bipolar materials are developed using carbazole and 9,9-dimethyl-9,10-dihydroacridine as hole-transporting groups, pyridine as electron-transporting groups, and biphenyl and
H2O2‐Responsive NIR‐II AIE Nanobomb for Carbon Monoxide Boosting Low‐Temperature Photothermal Therapy
Publisher: Wiley
Date: 29-07-2022
Abstract: Low‐temperature photothermal therapy (PTT), which circumvents the limitations of conventional PTT (e.g., thermotolerance and adverse effects), is an emerging therapeutic strategy which shows great potential for future clinical applications. The expression of heat shock proteins (HSPs) can dramatically impair the therapeutic efficacy of PTT. Thus, inhibition of HSPs repair and reducing the damage of nearby normal cells is crucial for improving the efficiency of low‐temperature PTT. Herein, we developed a nanobomb based on the self‐assembly of NIRII AIE polymer PBPTV and carbon monoxide (CO) carrier polymer mPEG(CO). This smart nanobomb can be exploded in a tumor microenvironment in which hydrogen peroxide is overexpressed and release CO into cancer cells to significantly inhibit the expression of HSPs and hence improve the antitumor efficiency of the low‐temperature PTT.
Aggregationsinduzierte Emission: Einblicke auf Aggregatebene
Publisher: Wiley
Date: 14-05-2020
A Multiresponsive Functional AIEgen for Spatiotemporal Pattern Control and All‐round Information Encryption
Publisher: Wiley
Date: 22-03-2023
Abstract: Functional materials with multi‐responsive properties and good controllability are highly desired for developing bioinspired and intelligent multifunctional systems. Although some chromic molecules have been developed, it is still challenging to realize in situ multicolor fluorescence changes based on a single luminogen. Herein, we reported an aggregation‐induced emission (AIE) luminogen called CPVCM, which can undergo a specific amination with primary amines to trigger luminescence change and photoarrangement under UV irradiation at the same active site. Detailed mechanistic insights were carried out to illustrate the reactivity and reaction pathways. Accordingly, multiple‐colored images, a quick response code with dynamic colors, and an all‐round information encryption system were demonstrated to show the properties of multiple controls and responses. It is believed that this work not only provides a strategy to develop multiresponsive luminogens but also develops an information encryption system based on luminescent materials.
Room-Temperature Metal-Free Multicomponent Polymerizations of Elemental Selenium toward Stable Alicyclic Poly(oxaselenolane)s with High Refractive Index
Publisher: American Chemical Society (ACS)
Date: 14-09-2021
DOI: 10.1021/JACS.1C06732
How Do Molecular Motions Affect Structures and Properties at Molecule and Aggregate Levels?
Publisher: American Chemical Society (ACS)
Date: 22-07-2021
DOI: 10.1021/JACS.1C05647
Abstract: Molecular motions are essential natures of matter and play important roles in their structures and properties. However, owing to the ersity and complexity of structures and behaviors, the study of motion-structure-property relationships remains a challenge, especially at all levels of structural hierarchy from molecules to macro-objects. Herein, luminogens showing aggregation-induced emission (AIE), namely, 9-(pyrimidin-2-yl)-carbazole (PyCz) and 9-(5-R-pyrimidin-2-yl)-carbazole [R = Cl (ClPyCz), Br (BrPyCz), and CN (CyPyCz)], were designed and synthesized, to decipher the dependence of materials' structures and properties on molecular motions at the molecule and aggregate levels. Experimental and theoretical analysis demonstrated that the active intramolecular motions in the excited state of all molecules at the single-molecule level endowed them with more twisted structural conformations and weak emission. However, owing to the restriction of intramolecular motions in the nano/macroaggregate state, all the molecules assumed less twisted conformations with bright emission. Unexpectedly, intermolecular motions could be activated in the macrocrystals of ClPyCz, BrPyCz, and CyPyCz through the introduction of external perturbations, and synergic strong and weak intermolecular interactions allowed their crystals to undergo reversible deformation, which effectively solved the problem of the brittleness of organic crystals, while endowing them with excellent elastic performance. Thus, the present study provided insights on the motion-structure-property relationship at each level of structural hierarchy and offered a paradigm to rationally design multifunctional AIE-based materials.
Preparation of Multifunctional Hyperbranched Poly(β-aminoacrylate)s by Spontaneous Amino-yne Click Polymerization
Publisher: American Chemical Society (ACS)
Date: 17-06-2020
Mapping the Regioisomeric Space and Visible Color Range of Purely Organic Dual Emitters with Ultralong Phosphorescence Components: From Violet to Red Towards Pure White Light
Publisher: Wiley
Date: 07-12-2022
Abstract: We mapped the entire visible range of the electromagnetic spectrum and achieved white light emission (CIE: 0.31, 0.34) by combining the intrinsic ns‐fluorescence with ultralong ms‐phosphorescence from purely organic dual emitters. We realized small molecular materials showing high photoluminescence quantum yields (Φ L ) in the solid state at room temperature, achieved by active exploration of the regioisomeric substitution space. Chromophore stacking‐supported stabilization of triplet excitons with assistance from enhanced intersystem crossing channels in the crystalline state played the primary role for the ultra‐long phosphorescence. This strategy covers the entire visible spectrum, based on organic phosphorescent emitters with versatile regioisomeric substitution patterns, and provides a single molecular source of white light with long lifetime (up to 163.5 ms) for the phosphorescent component, and high overall photoluminescence quantum yields (up to Φ L =20 %).
Hydrogen peroxide-responsive AIE probe for imaging-guided organelle targeting and photodynamic cancer cell ablation
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1QM00328C
Abstract: A versatile red/near-infrared AIE probe, TTPy-H2O2 , was developed for the specific visualization of H 2 O 2 with mitochondria targeting ability, meanwhile achieving efficient photodynamic therapy for cancer cells.
Differential fluorescent response to amino acids based on metal–organic framework Zn-PBC
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3DT02522E
Hypoxia-activated probe for NIR fluorescence and photoacoustic dual-mode tumor imaging
Publisher: Elsevier BV
Date: 03-2021
Syntheses, properties, and applications of CO2-based functional polymers
Publisher: Elsevier BV
Date: 02-2022
Activity-Based Sensing: Achieving Chemical Selectivity through Chemical Reactivity
Publisher: American Chemical Society (ACS)
Date: 21-01-2020
Aggregation-Induced Emission Luminogens for Activity-Based Sensing
Publisher: American Chemical Society (ACS)
Date: 22-08-2019
DOI: 10.1021/ACS.ACCOUNTS.9B00305
Abstract: Fluorescent sensing has emerged as a powerful tool for detecting various analytes and visualizing numerous biological processes by virtue of its superb sensitivity, rapidness, excellent temporal resolution, easy operation, and low cost. Of particular interest is activity-based sensing (ABS), a burgeoning sensing approach that is actualized on the basis of dynamic molecular reactivity rather than conventional lock-and-key molecular recognition. ABS has been recognized to possess some distinct advantages, such as high specificity, extraordinary sensitivity, and accurate signal outputs. A majority of ABS sensors are constructed by modifying conventional fluorogens, which are strongly emissive when molecularly dissolved in solvents but experience emission quenching upon aggregate formation or concentration increase. The aggregation-caused quenching (ACQ) phenomenon leads to a limited amount of labeling of the analyte with the sensor and low photobleaching resistance, which could impede practical applications of the ABS protocol. As an anti-ACQ phenomenon, aggregation-induced emission (AIE) provides a straightforward solution to the ACQ problem. Thanks to their intrinsic advantages, including high photobleaching threshold, high signal-to-noise ratio, fluorescence turn-on nature, and large Stokes shift, AIE-active luminogens (AIEgens) represent a class of extraordinary fluorogen alternatives for the ABS protocol. The use of AIEgen-involved ABS can integrate the advantages of AIEgens and ABS, and additionally, the AIE process offers some unique properties to the ABS approach. For instance, in some cases of water-soluble AIEgen-involved ABS, chemical reaction not only leads to a chang in the emission color of the AIEgens but also causes solubility variations, which could result in specific "light-up" signaling. In this Account, the basic concepts and mechanistic insights of the ABS approach involving the AIE principle are briefly summarized, and then we highlight the new breakthroughs, seminal studies, and trends in the area that have been most recently reported by our group. This emerging sensing protocol has been successfully utilized for detecting an array of targets including ions, small molecules, biomacromolecules, and microenvironments, all of which closely relate to human health, medical, and public concerns. These detections are smoothly achieved on the basis of various reactions (e.g., hydrolysis, boronate cleavage, dephosphorylation, addition, cyclization, and rearrangement reactions) through different sensing principles. In these studies, the AIEgen-involved ABS strategy generally shows good biocompatibility, high selectivity, excellent reliability and high signal contrast, strongly indicating its great potential for high-tech innovations in the sensing field, among which bioprobing is of particular interest. With this Account, we hope to spark new ideas and inspire new endeavors in this emerging research area, further promoting state-of-the-art developments in the field of sensing.
Type I Photosensitization with Strong Hydroxyl Radical Generation in NIR Dye Boosted by Vigorous Intramolecular Motions for Synergistic Therapy
Publisher: Wiley
Date: 03-07-2023
Abstract: Development of type I photosensitizers (PSs) with strong hydroxyl radical ( · OH) formation is particularly important in the anaerobic tumor treatment. On the other hand, it is challenging to obtain an efficient solid‐state intramolecular motion to promote the development of molecular machine and molecular motor. However, the relationship between them is never revealed. In this work, a pyrazine‐based near‐infrared type I PS with remarkable donor–acceptor effect is developed. Notably, the intramolecular motions are almost maximized by the combination of intramolecular and intermolecular engineering to simultaneously introduce the unlimited bond stretching vibration and boost the group rotation. The photothermal conversion caused by the intramolecular motions is realized with efficiency as high as 86.8%. The D–A conformation of PS can also induce a very small singlet‐triplet splitting of 0.07 eV, which is crucial to promote the intersystem crossing for the triplet sensitization. Interestingly, its photosensitization is closely related to the intramolecular motions, and a vigorous motion may give rise to a strong · OH generation. In view of its excellent photosensitization and photothermal behavior, the biocompatible PS exhibits a superior imaging‐guided cancer synergistic therapy. This work stimulates the development of advanced PS for the biomedical application and solid‐state intramolecular motions.
The role of amide (n,π∗) transitions in polypeptide clusteroluminescence
Publisher: Elsevier BV
Date: 02-2022
Ratiometric Detection of Mitochondrial Thiol with a Two-Photon Active AIEgen
Publisher: American Chemical Society (ACS)
Date: 31-05-2019
Abstract: In clinical studies, thiol measurement in the whole blood is of diagnostic and prognostic significance. In addition, the detection of mitochondrial thiol is very important for investigating cellular functions or dysfunctions. Here, a ratiometric aggregation-induced emission luminogen (AIEgen) called TPE-PBP for thiol detection was developed by introducing a
Fluorescent polymer cubosomes and hexosomes with aggregation-induced emission
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1SC00270H
Abstract: Fluorescent Im 3̄ m cubosome and P 6 mm hexosome with aggregation-induced emission (AIE) were reported, which were formed by hiphilic block copolymers PEG- b -PTPEMA. The length of hydrophobic block PTPEMA was adjusted to control morphology formation.
Boosting Highly Efficient Hydrocarbon Solvent-Processed All-Polymer-Based Organic Solar Cells by Modulating Thin-Film Morphology
Publisher: American Chemical Society (ACS)
Date: 15-07-2021
Boosting Non‐Radiative Decay to Do Useful Work: Development of a Multi‐Modality Theranostic System from an AIEgen
Publisher: Wiley
Date: 20-03-2019
Recent advances in high performance blue organic light-emitting diodes based on fluorescence emitters
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9TC06441A
Abstract: This review summarizes recent advances in blue OLEDs based on fluorescence emitters, especially focusing on the different mechanisms involving the emitters and devices.
Facile Multicomponent Polymerizations toward Unconventional Luminescent Polymers with Readily Openable Small Heterocycles
Publisher: American Chemical Society (ACS)
Date: 09-04-2018
DOI: 10.1021/JACS.8B01991
Abstract: Heterocyclic polymers have gained enormous attention for their unique functionalities and wide applications. In contrast with the well-studied polymer systems with five- or six-membered heterocycles, functional polymers with readily openable small-ring heterocycles have rarely been explored due to their large synthetic difficulty. Herein, a facile one-pot multicomponent polymerization to such polymers is developed. A series of functional polymers with multisubstituted and heteroatom-rich azetidine frameworks are efficiently generated at room temperature in high atom economy from handy monomers. The four-membered azetidine rings in the polymer skeletons can be easily transformed into amide and amidine moieties via a fast and efficient acid-mediated ring-opening reaction, producing brand-new polymeric materials with distinctive properties. All the as-prepared azetidine-containing polymers exhibit intrinsic visible luminescence in the solid state under long-wavelength UV irradiation even without conventionally conjugated structures. Such unconventional luminescence is attributed to the clusteroluminogens formed by through-space electronic interactions of heteroatoms and phenyl rings. All the obtained polymers show excellent optical transparency, high and tunable refractive indices, low optical dispersions and good photopatternability, which make them promising materials in various advanced electronic and optoelectronic devices. The ring-opened polymers can also function as a lysosome-specific fluorescent probe in biological imaging.
Bright Bacterium for Hypoxia‐Tolerant Photodynamic Therapy Against Orthotopic Colon Tumors by an Interventional Method
Publisher: Wiley
Date: 18-06-2021
Abstract: While promising, the efficacy of aggregation‐induced emission (AIE)‐based photodynamic therapy (PDT) is limited by several factors including limited depth of laser penetration and intratumoral hypoxia. In the present study, a novel bacteria‐based AIEgen (TBP‐2) hybrid system (AE) is developed, that is able to facilitate the hypoxia‐tolerant PDT treatment of orthotopic colon tumors via an interventional method. For this approach, an interventional device is initially designed, composed of an optical fiber and an endoscope, allowing for clear visualization of the position of the orthotopic tumor within the abdominal cavity. It is then possible to conduct successful PDT treatment of this hypoxic tumor via laser irradiation, as the TBP‐2 is able to generate hydroxyl radicals (•OH) via a type I mechanism within this hypoxic microenvironment. Moreover, this interventional approach is proved to significantly impair orthotopic colon cancer growth and overcame PDT defects. This study is the first report involving such an interventional PDT strategy to knowledge, and it has the potential to complement other treatment modalities while also highlighting novel approaches to the design of hybrid AIEgen systems.
Direct Room Temperature Synthesis of α-CsPbI3 Perovskite Nanocrystals with High Photoluminescence Quantum Yields: Implications for Lighting and Photovoltaic Applications
Publisher: American Chemical Society (ACS)
Date: 27-04-2022
Ultrafast Delivery of Aggregation-Induced Emission Nanoparticles and Pure Organic Phosphorescent Nanocrystals by Saponin Encapsulation
Publisher: American Chemical Society (ACS)
Date: 09-10-2017
DOI: 10.1021/JACS.7B08710
Abstract: Saponins are a class of naturally occurring bioactive and biocompatible hiphilic glycosides produced by plants. Some saponins, such as α-hederin, exhibit unique cell membrane interactions. At concentrations above their critical micelle concentration, they will interact and aggregate with membrane cholesterol to form transient pores in the cell membrane. In this project, we utilized the unique permeabilization and hiphilic properties of saponins for the intracellular delivery of deep-red-emitting aggregation-induced emission nanoparticles (AIE NPs) and pure organic room-temperature phosphorescent nanocrystals (NCs). We found this method to be biocompatible, inexpensive, ultrafast, and applicable to deliver a wide variety of AIE NPs and NCs into cancer cells.
A simple strategy for the efficient design of mitochondria-targeting NIR-II phototheranostics
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D2TB02295H
Abstract: The pursuit of phototheranostic agents with near-infrared II emission, high photothermal conversion efficiency and the robust generation of reactive oxygen species (ROS) in the aggregated state is always in high demand but remains a big challenge.
Aggregation-induced delayed fluorescence luminogens: the innovation of purely organic emitters for aqueous electrochemiluminescence
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1SC02918E
Abstract: Electrochemiluminescence (ECL) using an aggregation-induced delayed fluorescence (AIDF) organic luminogen, i.e. AIDF-ECL, was reported for the first time, featuring “lighting” dark triplets ( ca. 75% in total) for all-exciton-harvesting ECL applications.
Long-Lived Afterglow from Elemental Sulfur Powder: Synergistic Effects of Impurity and Structure
Publisher: American Chemical Society (ACS)
Date: 20-08-2022
Spontaneous and Fast Molecular Motion at Room Temperature in the Solid State
Publisher: Wiley
Date: 28-02-2019
Abstract: The development of molecular machines requires new building blocks which are easy to characterize and visualize to realize a complexity comparable to their natural counterparts such as biological enzymes. Furthermore, with the desire to build functional nanobots capable of navigating living organisms, it is necessary that the building blocks show mobility even in the solid state. Herein we report a system which is emissive in the amorphous state but is non-fluorescent in the crystalline state due to the formation of extensive π-π interactions. This dual nature could be exploited for easy visualization of its solid-state molecular rearrangement. The emission of the amorphous film was quenched as the molecules spontaneously formed π-π interactions even in the solid state. Scratching the non-emissive film destroyed the interactions and restored the emission of the film. The emission quickly disappeared with an average lifetime of 20 s as the compound reformed the π-network even at room temperature.
A rapid method for the determination of stable hydrogen isotope ratios of acetic acid in vinegar
Publisher: Authorea, Inc.
Date: 15-10-2023
Efficient Ultraviolet Organic Light-Emitting Diodes with a CIEy of 0.04 and Negligible-Efficiency Roll-Off
Publisher: American Chemical Society (ACS)
Date: 16-02-2022
Economical synthesis of functional aromatic polythioamides from KOH-assisted multicomponent polymerizations of sulfur, aromatic diamines and dialdehydes
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D2PY01560A
Abstract: A series of aromatic polythioamides with high gold extraction efficiency and high refractive index have been synthesized through the KOH-assisted multicomponent polymerization of elemental sulfur, aromatic diamines and aromatic dialdehydes.
Nanomaterials with Supramolecular Assembly Based on AIE Luminogens for Theranostic Applications
Publisher: Wiley
Date: 04-11-2020
Pursuing Phase Transitions of a Concentrated Polymer Solution by In Situ Fluorescence Measurements Based On Aggregation-Induced Emission
Publisher: American Chemical Society (ACS)
Date: 17-10-2022
DOI: 10.1021/ACS.JPCLETT.2C02741
Abstract: Concentration-dependent phase transitions in concentrated solutions have remained speculation due to the serious impediment of macromolecule dynamics by intensive topological entanglement or intermolecular interaction as well as the absence of powerful tool for detecting changes in chain or segment movement. Herein, taking a general polymer, namely, poly(vinyl alcohol) (PVA), as an ex le, a water-soluble fluorescent molecule with aggregation-induced emission (AIE) is introduced into the PVA solutions as a chain dynamics indicator to investigate phase transitions at high concentrations through in situ monitoring of the solvent evaporation process. Two turning points of fluorescent intensity are observed for the first time at mean concentrations of ∼25% and ∼45%, corresponding to the gelation and amorphous-to-crystalline transitions, respectively. Our work offers a fundamental insight into the physical nature of concentrate-dependent nonequilibrium transitions and develops a reliable and sensitive approach based on the AIE phenomenon for following high-concentration-triggered property changes of a polymer solution.
Charge control of fluorescent probes to selectively target the cell membrane or mitochondria: theoretical prediction and experimental validation
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9MH00906J
Abstract: Using a multiscale molecular modeling protocol, we proposed a design strategy of fluorescent probes to selectively target the cell membrane or mitochondria.
Loss-of-function mutations inSCN4Acause severe foetal hypokinesia or ‘classical’ congenital myopathy
Publisher: Oxford University Press (OUP)
Date: 22-12-2015
DOI: 10.1093/BRAIN/AWV352
Robust Supramolecular Nano‐Tunnels Built from Molecular Bricks**
Publisher: Wiley
Date: 09-02-2021
Visualization and Manipulation of Solid-State Molecular Motions in Cocrystallization Processes
Publisher: American Chemical Society (ACS)
Date: 21-06-2021
DOI: 10.1021/JACS.1C02594
Spiro-Functionalized Diphenylethenes: Suppression of a Reversible Photocyclization Contributes to the Aggregation-Induced Emission Effect
Publisher: American Chemical Society (ACS)
Date: 16-06-2019
DOI: 10.1021/JACS.9B04426
Abstract: Many aggregation-induced emission (AIE) materials are featured by the diphenylethene (DPE) moiety which exhibits rich photophysical and photochemical activities. The understanding of these activities behind AIE is essential to guide the design of fluorescent materials with improved performance. Herein by fusing a flexible DPE with a rigid spiro scaffold, we report a class of novel deep-blue material with solid-state fluorescent quantum yield (Φ
An easily synthesized AIE luminogen for lipid droplet-specific super-resolution imaging and two-photon imaging
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0QM00682C
Abstract: A synergetic imaging platform was established to achieve LDs-specific imaging by STED nanoscopy and TPF microscopy. Benefiting from its high PLQYs, outstanding photo-stability, and high LDs specificity, a superior resolution in cells and a deep penetration depth in tissues were achieved.
Strategies to Enhance the Photosensitization: Polymerization and the Donor–Acceptor Even–Odd Effect
Publisher: Wiley
Date: 22-10-2018
Pyrene-based aggregation-induced emission luminogens (AIEgens) with less colour migration for anti-counterfeiting applications
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1TC03022A
Abstract: A series of pyrene-based AIEgens have been employed in the preparation of fluorescent inks with less colour migration for anti-counterfeiting applications over the ultra-low to high concentration range and avoids the ACQ effect.
Upregulating Aggregation‐Induced‐Emission Nanoparticles with Blood–Tumor‐Barrier Permeability for Precise Photothermal Eradication of Brain Tumors and Induction of Local Immune Responses
Publisher: Wiley
Date: 23-04-2021
Abstract: Compared to other tumors, glioblastoma (GBM) is extremely difficult to treat. Recently, photothermal therapy (PTT) has demonstrated advanced therapeutic efficacy however, because of the relatively low tissue‐penetration efficiency of laser light, its application in deep‐seated tumors remains challenging. Herein, bradykinin (BK) aggregation‐induced‐emission nanoparticles (BK@AIE NPs) are synthesized these offer selective penetration through the blood–tumor barrier (BTB) and strong absorbance in the near‐infrared region (NIR). The BK ligand can prompt BTB adenosine receptor activation, which enhances transportation and accumulation inside tumors, as confirmed by T 1 ‐weighted magnetic resonance and fluorescence imaging. The BK@AIE NPs exhibit high photothermal conversion efficiency under 980 nm NIR laser irradiation, facilitating the treatment of deep‐seated tumors. Tumor progression can be effectively inhibited to extend the survival span of mice after spatiotemporal PTT. NIR irradiation can eradicate tumor tissues and release tumor‐associated antigens. It is observed that the PTT treatment of GBM‐bearing mice activates natural killer cells, CD3 + T cells, CD8 + T cells, and M1 macrophages in the GBM area, increasing the therapeutic efficacy. This study demonstrates that NIR‐assisted BK@AIE NPs represent a promising strategy for the improved systematic elimination of GBMs and the activation of local brain immune privilege.
A Dihydroazulene‐Based Photofluorochromic AIE System for Rewritable 4D Information Encryption
Publisher: Wiley
Date: 03-08-2022
Abstract: Dynamic patterns based on luminescent materials play an essential role in the digital age. However, it is still challenging to develop highly emissive photofluorochromic materials with dynamic behaviors to store information with multiple characteristics. Here, we report a series of dihydroazulene‐based compounds which show typical aggregation‐induced emission (AIE) effect. Moreover, the photo‐switching ability of the dihydroazulene units, undergoing light‐induced ring‐opening, enables photofluorochromic properties. The photofluorochromism also shows quantitively described responses to time and temperature via a reverse ring‐closing process. Ultimately, a rewritable 4D information system, embedded with a quick response code, dot matrix with microstructures, color matrix of fluorescence, and time/temperature‐dependent intensity change, is established with dynamic patterns. This work not only develops a dynamic AIE skeleton with photofluorochromic properties but also provides a new strategy for information encryption and cybernetics.
Benzothiazole-Based AIEgen with Tunable Excited-State Intramolecular Proton Transfer and Restricted Intramolecular Rotation Processes for Highly Sensitive Physiological pH Sensing
Publisher: American Chemical Society (ACS)
Date: 18-04-2018
DOI: 10.1021/ACSSENSORS.7B00820
Abstract: In this work, a benzothiazole-based aggregation-induced emission luminogen (AIEgen) of 2-(5-(4-carboxyphenyl)-2-hydroxyphenyl)benzothiazole (3) was designed and synthesized, which exhibited multifluorescence emissions in different dispersed or aggregated states based on tunable excited-state intramolecular proton transfer (ESIPT) and restricted intramolecular rotation (RIR) processes. 3 was successfully used as a ratiometric fluorescent chemosensor for the detection of pH, which exhibited reversible acid/base-switched yellow/cyan emission transition. More importantly, the pH jump of 3 was very precipitous from 7.0 to 8.0 with a midpoint of 7.5, which was well matched with the physiological pH. This feature makes 3 very suitable for the highly sensitive detection of pH fluctuation in bios les and neutral water s les. 3 was also successfully used as a ratiometric fluorescence chemosensor for the detection of acidic and basic organic vapors in test papers.
Fluorescent aggregation-induced emission (AIE)-based thermosetting electrospun nanofibers: fabrication, properties and applications
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9QM00342H
Abstract: Preparation and study of the rapid formation of electrospun fluorescent thermosetting fibers via chemical knitting of a thermosetting polymer with AIEgens and their possible applications as fluorescent probes.
Molecular-level enhanced clusterization-triggered emission of nonconventional luminophores in dilute aqueous solution
Publisher: Springer Science and Business Media LLC
Date: 25-01-2023
DOI: 10.1038/S41467-023-36115-W
Abstract: Nonconjugated and nonaromatic luminophores based on clustering-triggered emission derived from through-space conjugation have drawn emerging attention in recent years. The reported nonconventional luminophores are emissive in concentrated solution and/or in the solid state, but they tend to be nonluminescent in dilute solution, which greatly limits their sensing and imaging applications. Herein, we design unique clusteroluminogens through modification of cyclodextrin (CD) with amino acids to enable the intermolecular and intramolecular clusterization of chromophores in CD-based confined space. The resulted through-space interactions along with conformation rigidification originated from hydrogen bond interaction and complexation interaction generate blue to cyan fluorescence even in the dilute solution (0.035 wt.%, quantum yield of 40.70%). Moreover, the prepared histidine-modified CD (CDHis) is demonstrated for fluorescent detection of chlortetracycline with high sensitivity and selectivity. This work provides a new and universal strategy to synthesize nonconventional luminophores with bright fluorescence in dilute aqueous solution through molecular-level enhanced clusterization-triggered emission.
Aroylacetylene-Based Amino-Yne Click Polymerization toward Nitrogen-Containing Polymers
Publisher: American Chemical Society (ACS)
Date: 17-03-2020
Near‐Infrared AIE Dots with Chemiluminescence for Deep‐Tissue Imaging
Publisher: Wiley
Date: 22-09-2020
Multifunctional AuI‐based AIEgens: Manipulating Molecular Structures and Boosting Specific Cancer Cell Imaging and Theranostics
Publisher: Wiley
Date: 05-03-2020
Abstract: Gold(I) N‐heterocyclic carbene (Au I ‐NHC) complexes have emerged as potential anticancer agents owing to their high cytotoxicity and stability. Integration of their above unique functions with customized aggregation‐induced emission (AIE) luminogens to achieve specific bioimaging and efficient theranostics to cancer is highly desirable but is rarely studied. Now, a series of novel Au I ‐NHC compounds were developed with AIE characteristics. A complex with a PPh 3 ligand was selected out as it could achieve both prominent specific imaging of various cancer cells and efficient inhibition of their growth with negligible toxic effects on normal cells due to the targeting binding and strong inhibition towards thioredoxin reductase. This complex could also act as a powerful radiosensitizer to boost the anticancer efficacy with performance superior to that of popularly used auranofin. It holds great potential as a specific and effective theranostic drug in cancer diagnosis and precise therapy.
Tuning aggregation-induced emission nanoparticle properties under thin film formation
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9QM00585D
Abstract: The preparation of AIE nanoparticles under thin film formation controls their size and the associated fluorescent intensity, with the smaller nanoparticles significantly increasing brightness.
Self-Guiding Polymeric Prodrug Micelles with Two Aggregation-Induced Emission Photosensitizers for Enhanced Chemo-Photodynamic Therapy
Publisher: American Chemical Society (ACS)
Date: 15-01-2021
An Easily Accessible Ionic Aggregation‐Induced Emission Luminogen with Hydrogen‐Bonding‐Switchable Emission and Wash‐Free Imaging Ability
Publisher: Wiley
Date: 23-03-2018
A dish-like molecular architecture for dynamic ultralong room-temperature phosphorescence through reversible guest accommodation
Publisher: Springer Science and Business Media LLC
Date: 02-12-2022
DOI: 10.1038/S41467-022-35155-Y
Abstract: Developing dynamic organic ultralong room-temperature phosphorescent (URTP) materials is of practical importance in various applications but remains a challenge due to the difficulty in manipulating aggregate structures. Herein, we report a dish-like molecular architecture via a bottom-up way, featuring guest-responsive dynamic URTP. Through controlling local fragment motions in the molecular architecture, fascinating dynamic URTP performances can be achieved in response to reversible accommodation of various guests, including solvents, alkyl bromides and even carbon dioxide. Large-scale regulations of phosphorescence lifetime (100-fold) and intensity (10-fold) can be realized, presenting a maximum phosphorescence efficiency and lifetime of 78.8% and 483.1 ms, respectively. Moreover, such a dish-like molecular architecture is employed for temperature-dependent multiple information encryption and visual identification of linear alkyl bromides. This work can not only deepen our understanding to construct multifunctional organic aggregates, but also facilitate the design of high-performance dynamic URTP materials and enrich their practical applications.
Polycouplings of Alkynyl Bromides and Sulfonamides toward Poly(ynesulfonamide)s with Stable Csp–N Bonds
Publisher: American Chemical Society (ACS)
Date: 28-07-2017
Tetraphenylpyrazine decorated 1,3-di(9H-carbazol-9-yl)benzene (mCP): a new AIE-active host with enhanced performance in organic light-emitting diodes
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9TC02748C
Abstract: Decorating a conventional mCP host with a tetraphenylpyrazine moiety generates a new AIE-active host, from which better device performance was realized.
Photoresponsive spiro-polymers generated in situ by C–H-activated polyspiroannulation
Publisher: Springer Science and Business Media LLC
Date: 02-12-2019
DOI: 10.1038/S41467-019-13308-W
Abstract: The development of facile and efficient polymerizations toward functional polymers with unique structures and attractive properties is of great academic and industrial significance. Here we develop a straightforward C–H-activated polyspiroannulation route to in situ generate photoresponsive spiro-polymers with complex structures. The palladium(II)-catalyzed stepwise polyspiroannulations of free naphthols and internal diynes proceed efficiently in dimethylsulfoxide at 120 °C without the constraint of apparent stoichiometric balance in monomers. A series of functional polymers with multisubstituted spiro-segments and absolute molecular weights of up to 39,000 are produced in high yields (up to 99%). The obtained spiro-polymers can be readily fabricated into different well-resolved fluorescent photopatterns with both turn-off and turn-on modes based on their photoinduced fluorescence change. Taking advantage of their photoresponsive refractive index, we successfully apply the polymer thin films in integrated silicon photonics techniques and achieve the permanent modification of resonance wavelengths of microring resonators by UV irradiation.
Facilitation of molecular motion to develop turn-on photoacoustic bioprobe for detecting nitric oxide in encephalitis
Publisher: Springer Science and Business Media LLC
Date: 11-02-2021
DOI: 10.1038/S41467-021-21208-1
Abstract: Nitric oxide (NO) is an important signaling molecule overexpressed in many diseases, thus the development of NO-activatable probes is of vital significance for monitoring related diseases. However, sensitive photoacoustic (PA) probes for detecting NO-associated complicated diseases (e.g., encephalitis), have yet to be developed. Herein, we report a NO-activated PA probe for in vivo detection of encephalitis by tuning the molecular geometry and energy transformation processes. A strong donor-acceptor structure with increased conjugation can be obtained after NO treatment, along with the active intramolecular motion, significantly boosting “turn-on” near-infrared PA property. The molecular probe exhibits high specificity and sensitivity towards NO over interfering reactive species. The probe is capable of detecting and differentiating encephalitis in different severities with high spatiotemporal resolution. This work will inspire more insights into the development of high-performing activatable PA probes for advanced diagnosis by making full use of intramolecular motion and energy transformation processes.
Reverse Thinking of the Aggregation‐Induced Emission Principle: Amplifying Molecular Motions to Boost Photothermal Efficiency of Nanofibers**
Publisher: Wiley
Date: 15-09-2020
Multi-stimuli responsive cyanostilbene derivatives: pH, amine vapor sensing and mechanoluminescence
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0QM00113A
Abstract: Two carboxyl substituted cyanostilbene derivatives can serve as novel mechanoluminescence materials and fluorescent sensors towards pH change and also amine vapors.
Ultralong Room-Temperature Phosphorescence with Second-level Lifetime in Water Based on Cyclodextrin Supramolecular Assembly
Publisher: American Chemical Society (ACS)
Date: 29-06-2023
A Nanotheranostic System Combining Lysosomal Cell Death and Nuclear Apoptosis Functions for Synergistic Cancer Therapy and Addressing Drug Resistance
Publisher: Wiley
Date: 07-08-2021
Abstract: The lysosome is a prominent and crucial target for actualizing anticancer therapy due to the outstanding therapeutic effect of lysosomal cell death on apoptosis‐ and drug‐resistance cancer. Exploration of multifunctional materials involving lysosome‐targeting drugs for achieving efficient cancer treatment is definitely appealing, yet a significantly challenging task. Herein, a versatile nanotheranostic system allowing all cancer cell‐targeting, tumor microenvironment stimuli‐responsive, fluorescence imaging, lysosome‐targeting chemotherapy and nucleus‐targeting chemotherapy functions was tactfully designed and constructed, by encapsulating both doxorubicin and a lysosome‐specific targeting drug with aggregation‐induced emission features in functional hiphilic polymers. Both in vitro and in vivo studies revealed that the presented nanotheranostic system exhibited synergistic anticancer therapy effects, negligible systemic toxicity, and remarkable inhibition of drug‐resistant cancer cells. This study thus brings a new insight into the development of a superior effective protocol for practical cancer treatment.
AIE-Active Poly(phenyleneethynylene)s for Fluorescence and Raman Dual-Modal Imaging and Drug-Resistant Bacteria Killing
Publisher: American Chemical Society (ACS)
Date: 15-06-2021
DOI: 10.26434/CHEMRXIV.14776893.V1
Abstract: Poly(phenyleneethynylene) (PPE) is a widely used functional conjugated polymer with applications ranging from organic optoelectronics and fluorescence sensors to optical imaging and theranostics. However, the fluorescence efficiency of PPE in aggregate states is generally not as good as their solution states, which greatly compromises their performance in fluorescence-related applications. Herein, we design and synthesize a series of PPE derivatives with typical aggregation-induced emission (AIE) properties. In these PPEs, the diethylamino-substituted tetraphenylethene units function as the long-wavelength AIE source and the alkyl side chains serve as the functionalization site. The obtained AIE-active PPEs with large π-conjugation show strong aggregate-state fluorescence, interesting self-assembly behaviors, inherently enhanced alkyne vibrations in the Raman-silent region of cells, and efficient antibacterial activities. The PPE nanoparticles with good cellular uptake capability can clearly and sensitively visualize the tumor region and residual tumors via their fluorescence and Raman signals, respectively, to benefit the precise tumor surgery. After post-functionalization, the obtained PPE-based polyelectrolyte can preferentially image bacteria over mammalian cells and possesses efficient photodynamic killing capability against Gram-positive and drug-resistant bacteria. This work provides a feasible design strategy for developing multifunctional conjugated polymers with multimodal imaging capability as well as photodynamic antimicrobial ability.
Fluorogenic Ag+–Tetrazolate Aggregation Enables Efficient Fluorescent Biological Silver Staining
Publisher: Wiley
Date: 14-04-2018
Tumor‐Exocytosed Exosome/Aggregation‐Induced Emission Luminogen Hybrid Nanovesicles Facilitate Efficient Tumor Penetration and Photodynamic Therapy
Publisher: Wiley
Date: 03-06-2020
Abstract: The development of novel photosensitizing agents with aggregation‐induced emission (AIE) properties has fueled significant advances in the field of photodynamic therapy (PDT). An electroporation method was used to prepare tumor‐exocytosed exosome/AIE luminogen (AIEgen) hybrid nanovesicles (DES) that could facilitate efficient tumor penetration. Dexamethasone was then used to normalize vascular function within the tumor microenvironment (TME) to reduce local hypoxia, thereby significantly enhancing the PDT efficacy of DES nanovesicles, and allowing them to effectively inhibit tumor growth. The hybridization of AIEgen and biological tumor‐exocytosed exosomes was achieved for the first time, and combined with PDT approaches by normalizing the intratumoral vasculature as a means of reducing local tissue hypoxia. This work highlights a new approach to the design of AIEgen‐based PDT systems and underscores the potential clinical value of AIEgens.
Supramolecular materials based on AIE luminogens (AIEgens): construction and applications
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9CS00495E
Abstract: This review presents comprehensive discussions on the recent development in supramolecular materials based on luminogens with aggregation-induced emission (AIE) characteristics.
Adipocyte-Targeting Type I AIE Photosensitizer for Obesity Treatment via Photodynamic Lipid Peroxidation
Publisher: American Chemical Society (ACS)
Date: 31-05-2023
Endowing TADF luminophors with AIE properties through adjusting flexible dendrons for highly efficient solution-processed nondoped OLEDs
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0SC02194F
Abstract: Construction of core–dendron TADF emitters systematically: changing the behaviour of chromophores from aggregation-caused quenching to aggregation induced emission to develop high-performance fully solution-processed nondoped OLEDs.
A Two-in-One Janus NIR-II AIEgen with Balanced Absorption and Emission for Image-Guided Precision Surgery
Publisher: American Chemical Society (ACS)
Date: 05-10-2020
DOI: 10.26434/CHEMRXIV.13046684.V1
Abstract: Fluorescence imaging in the near-infrared II (NIR-II, 1000-1700 nm) region opens up new avenues for biological systems due to suppressed scattering and low autofluorescence at longer-wavelength photons. Nonetheless, the development of organic NIR-II fluorophores is still limited mainly due to the shortage of efficient molecular design strategy. Herein, we propose an approach of designing Janus NIR-II fluorophores by introducing electronic donors with distinct properties into one molecule. As a proof-of-concept, fluorescent dye 2TT- m,o C6B with both twisted and planar electronic donors displayed balanced absorption and emission which were absent in its parent compound. The key design strategy for Janus molecule is that it combines the merits of intense absorption from planar architecture and high fluorescence quantum yield from twisted motif. The resulting 2TT- m,o C6B nanoparticles exhibit a high molar absorptivity of 1.12 ⨯10 4 M -1 cm -1 at 808 nm and a NIR-II quantum yield of 3.7%, displaying a typical aggregation-induced emission (AIE) attribute. The highly bright and stable 2TT- m,o C6B nanoparticles assured NIR-II image-guided cancer surgery to resect submillimeter tumor nodules. The present study may inspire further development of molecular design philosophy for highly bright NIR-II fluorophores for biomedical applications.
How to Manipulate Through-Space Conjugation and Clusterolumi-nescence of Simple AIEgens with Isolated Phenyl Rings?
Publisher: American Chemical Society (ACS)
Date: 13-04-2021
DOI: 10.26434/CHEMRXIV.14400953.V1
Abstract: Apart from the traditional through-bond conjugation (TBC), through-space conjugation (TSC) is gradually proved as another important interaction in photophysical processes, especially for the recent observation of clusteroluminescence from nonconjugated molecules. Herein, simple and nonconjugated triphenylmethane (TPM) and its derivatives with electron-donating and electron-withdrawing groups were synthesized, and their photophysical properties were systematically studied. TPM was characterized with visible clusteroluminescence due to the intramolecular TSC. Experimental and theoretical results showed that the introduction of electron-donating groups into TPM could red-shift the wavelength and increase the efficiency of clusteroluminescence simultaneously, due to the increased electronic density and stabilization of TSC. However, TPM derivatives with electron-withdrawing groups showed inefficient or even quenched clusteroluminescence caused by the vigorous excited-state intramolecular motion and intermolecular photoinduced electron transfer process. This work provides a reliable strategy to manipulate TSC and clusteroluminescence.
Catalyst-Free Spontaneous Polymerization with 100% Atom Economy: Facile Synthesis of Photoresponsive Polysulfonates with Multifunctionalities
Publisher: American Chemical Society (ACS)
Date: 19-02-2021
Turning On Solid‐State Luminescence by Phototriggered Subtle Molecular Conformation Variations
Publisher: Wiley
Date: 03-12-2020
Polymerization-induced emission
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9MH01909J
Abstract: Polymerization-induced emission: a chemical route for uniting nonluminescent monomers into luminescent polymers.
On-site visual discrimination of transgenic food by water-soluble DNA-binding AIEgens
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9QM00279K
Abstract: Development of affordable, simple and effective methods for rapid on-site identification of genetically modified organisms (GMO) is urgent due to public concern for transgenic food.
Aggregation-Induced Emission Active Polyacrylates via Cu-Mediated Reversible Deactivation Radical Polymerization with Bioimaging Applications
Publisher: American Chemical Society (ACS)
Date: 08-05-2020
Tailoring the Molecular Properties with Isomerism Effect of AIEgens
Publisher: Wiley
Date: 15-07-2019
Transition-Metal-Free Polymerization of Bromoalkynes and Phenols
Publisher: American Chemical Society (ACS)
Date: 02-04-2019
Tailoring Noncovalent Interactions to Activate Persistent Room‐Temperature Phosphorescence from Doped Polyacrylonitrile Films
Publisher: Wiley
Date: 06-2021
Abstract: Organic phosphors exhibiting room‐temperature phosphorescence (RTP) in amorphous phase are good candidates for optoelectronic and biomedical applications. In this proof‐of‐concept work, a rational strategy to activate wide‐color ranged and persistent RTP from amorphous films by embedding electron‐rich organic phosphor into electron‐deficient matrix polyacrylonitrile (PAN) is presented. Through tailoring noncovalent interactions between the electron‐deficient PAN matrix and electron‐rich organic phosphors, an ultralong lifetime of 968.1 ms is obtained for doped film TBB‐6OMe@PAN. Control experiments conducted on the polymers polymethyl methacrylate (PMMA) and polystyrene (PS) without electron‐withdrawing groups, and organic phosphors containing electron‐withdrawing groups indicate that the persistent RTP of doped films may be triggered by strong electrostatic interactions between electron‐deficient PAN and electron‐rich organic phosphor. Further theoretical calculations including electrostatic potential distributions, binding energies, and energy decomposing analysis demonstrate that both electrostatic and dispersion interactions between electron‐deficient PAN and electron‐rich organic phosphor are responsible for the activation of persistent RTP of doped films. In addition, the doped film TBB‐6OMe@PAN still maintains brightness even after soaking in water for 12 weeks. This excellent water resistance not only is favorable for future applications but also demonstrates an advantage of electrostatic and dispersion interactions over hydrogen bonding interactions.
Mechanical single-molecule potentiometers with large switching factors from ortho-pentaphenylene foldamers
Publisher: Springer Science and Business Media LLC
Date: 08-01-2021
DOI: 10.1038/S41467-020-20311-Z
Abstract: Molecular potentiometers that can indicate displacement-conductance relationship, and predict and control molecular conductance are of significant importance but rarely developed. Herein, single-molecule potentiometers are designed based on ortho -pentaphenylene. The ortho- pentaphenylene derivatives with anchoring groups adopt multiple folded conformers and undergo conformational interconversion in solutions. Solvent-sensitive multiple conductance originating from different conformers is recorded by scanning tunneling microscopy break junction technique. These pseudo-elastic folded molecules can be stretched and compressed by mechanical force along with a variable conductance by up to two orders of magnitude, providing an impressively higher switching factor (114) than the reported values (ca. 1~25). The multichannel conductance governed by through-space and through-bond conducting pathways is rationalized as the charge transport mechanism for the folded ortho -pentaphenylene derivatives. These findings shed light on exploring robust single-molecule potentiometers based on helical structures, and are conducive to fundamental understanding of charge transport in higher-order helical molecules.
In Vivo Bioimaging of Silver Nanoparticle Dissolution in the Gut Environment of Zooplankton
Publisher: American Chemical Society (ACS)
Date: 20-11-2018
Abstract: Release of silver ions (Ag
Room Temperature One-Step Conversion from Elemental Sulfur to Functional Polythioureas through Catalyst-Free Multicomponent Polymerizations
Publisher: American Chemical Society (ACS)
Date: 23-04-2018
DOI: 10.1021/JACS.8B02886
Abstract: The utilization of sulfur is a global concern, considering the abundant and cheap source of sulfur from nature and petroleum industry, its limited consumption, and the safety/environmental problems caused during storage. The economic and efficient transformation of sulfur remains to be a great challenge for both academia and industry. Herein, a room temperature conversion from sulfur to functional polythioureas was reported through a catalyst-free multicomponent polymerization of sulfur, aliphatic diamines, and diisocyanides in air with 100% atom economy. The polymerization enjoys quick reaction and wide monomer scope, which affords 16 polythioureas with well-defined structures, high molecular weights ( M
Functional Scaffolds from AIE Building Blocks
Publisher: Elsevier BV
Date: 12-2020
Frontispiece: Fluorogenic Detection and Characterization of Proteins by Aggregation‐Induced Emission Methods
Publisher: Wiley
Date: 23-04-2019
Light-driven transformable optical agent with adaptive functions for boosting cancer surgery outcomes
Publisher: Springer Science and Business Media LLC
Date: 10-05-2018
DOI: 10.1038/S41467-018-04222-8
Abstract: Fluorescence and photoacoustic imaging have different advantages in cancer diagnosis however, combining effects in one agent normally requires a trade-off as the mechanisms interfere. Here, based on rational molecular design, we introduce a smart organic nanoparticle whose absorbed excitation energy can be photo-switched to the pathway of thermal deactivation for photoacoustic imaging, or to allow opposed routes for fluorescence imaging and photodynamic therapy. The molecule is made of a dithienylethene (DTE) core with two surrounding 2-(1-(4-(1,2,2-triphenylvinyl)phenyl)ethylidene)malononitrile (TPECM) units (DTE-TPECM). The photosensitive molecule changes from a ring-closed, for photoacoustic imaging, to a ring-opened state for fluorescence and photodynamic effects upon an external light trigger. The nanoparticles’ photoacoustic and fluorescence imaging properties demonstrate the advantage of the switch. The use of the nanoparticles improves the outcomes of in vivo cancer surgery using preoperative photoacoustic imaging and intraoperative fluorescent visualization hotodynamic therapy of residual tumours to ensure total tumour removal.
How to Manipulate Through-Space Conjugation and Clusteroluminescence of Simple AIEgens with Isolated Phenyl Rings
Publisher: American Chemical Society (ACS)
Date: 11-06-2021
DOI: 10.1021/JACS.1C03882
Facile Access to Far‐Red Fluorescent Probes with Through‐Space Charge‐Transfer Effects for In Vivo Two‐Photon Microscopy of the Mouse Cerebrovascular System
Publisher: Wiley
Date: 31-08-2022
Abstract: Much effort has been devoted to the generation of fluorescent probes by synthetic approaches. In this study, we developed a facile strategy to construct far‐red fluorescent probes based on through‐space charge transfer within complexes of acceptors and donors and their “twist+twist” interactions. Owing to their rare two‐photon excitation property, the complexes could be used for in vivo imaging of the mouse cerebrovascular system.
Diagnostic Absolute Configuration Determination of Tetraphenylethene Core-Based Chiral Aggregation-Induced Emission Compounds: Particular Fingerprint Bands in Comprehensive Chiroptical Spectroscopy
Publisher: American Chemical Society (ACS)
Date: 14-09-2017
Inside Back Cover: Heteroaromatic Hyperbranched Polyelectrolytes: Multicomponent Polyannulation and Photodynamic Biopatterning (Angew. Chem. Int. Ed. 35/2021)
Publisher: Wiley
Date: 21-06-2021
Advanced functional polymer materials
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0QM00025F
Abstract: This review presents the recent developments in the research hotspots of advanced functional polymers their concepts, design strategies, and applications are briefly discussed.
Fast Delivery of Multifunctional NIR‐II Theranostic Nanoaggregates Enabled by the Photoinduced Thermoacoustic Process
Publisher: Wiley
Date: 23-04-2023
Abstract: Multifunctional nanoaggregates are widely used in cancer phototheranostics. However, it is challenging to construct their multifunctionality with a single component, and deliver them rapidly and efficiently without complex modifications. Herein, a NIR‐absorbing small molecule named TBT‐2(TP‐DPA) is designed and certify its theranostic potentials. Then, their nanoaggregates, which are simply encapsulated by DSPE‐PEG, demonstrate a photothermal efficiency of 51% while keeping a high photoluminescence quantum yield in the NIR region. Moreover, the nanoaggregates can be excited and delivered by an 808 nm pulse laser to solid tumors within only 40 min. The delivery efficiency and theranostic efficacy are better than that of the traditional enhanced permeability and retention (EPR) effect (generally longer than 24 hours). This platform is first termed as the photoinduced thermoacoustic (PTA) process, and confirm its application requires both NIR‐responsive materials and pulse laser irradiation. This study not only inspires the design of multifunctional nanoaggregates, but also offers a feasible approach to their fast delivery. The platform reported here provides a promising prospect to boost the development of multifunctional theranostic drugs and maximize the efficacy of used medicines for their clinical applications.
Nanolab in a Cell: Crystallization-Induced In Situ Self-Assembly for Cancer Theranostic Amplification
Publisher: American Chemical Society (ACS)
Date: 28-07-2022
DOI: 10.1021/JACS.2C06111
Abstract: Conducting crystallization-assisted self-assembly in living biosystems to obtain large-size nanoparticles and achieve a specific physiological purpose remains an appealing yet significantly challenging task. In this study, we designed Au(I)-disulfide nanosheets containing an aggregation-induced emission photosensitizer, namely, NSs@TTVP, which exhibited pH-responsive crystallization-driven self-assembly capability in lysosomes of cancer cells and tumor tissues of mice. The crystallization process endowed NSs@TTVP with a microscale morphology, stronger fluorescence output, and highly enhanced reactive oxygen species production efficiency. The
Rational Design of NIR-II AIEgens with Ultrahigh Quantum Yields for Photo- and Chemiluminescence Imaging
Publisher: American Chemical Society (ACS)
Date: 10-08-2022
DOI: 10.1021/JACS.2C07443
Abstract: Fluorescence imaging in the second near-infrared window (NIR-II, 1000-1700 nm) using small-molecule dyes has high potential for clinical use. However, many NIR-II dyes suffer from the emission quenching effect and extremely low quantum yields (QYs) in the practical usage forms. The AIE strategy has been successfully utilized to develop NIR-II dyes with donor-acceptor (D-A) structures with acceptable QYs in the aggregate state, but there is still large room for QY improvement. Here, we rationally designed a NIR-II emissive dye named TPE-BBT and its derivative (TPEO-BBT) by changing the electron-donating triphenylamine unit to tetraphenylethylene (TPE). Their nanoparticles exhibited ultrahigh relative QYs of 31.5% and 23.9% in water, respectively. By using an integrating sphere, the absolute QY of TPE-BBT nanoparticles was measured to be 1.8% in water. Its crystals showed an absolute QY of 10.4%, which is the highest value among organic small molecules reported so far. The optimized D-A interaction and the higher rigidity of TPE-BBT in the aggregate state are believed to be the two key factors for its ultrahigh QY. Finally, we utilized TPE-BBT for NIR-II photoluminescence (PL) and chemiluminescence (CL) bioimaging through successive CL resonance energy transfer and Förster resonance energy transfer processes. The ultrahigh QY of TPE-BBT realized an excellent PL imaging quality in mouse blood vessels and an excellent CL imaging quality in the local arthrosis inflammation in mice with a high signal-to-background ratio of 130. Thus, the design strategy presented here brings new possibilities for the development of bright NIR-II dyes and NIR-II bioimaging technologies.
Y‐Shaped Pyrene‐Based Aggregation‐Induced Emission Blue Emitters for High‐Performance OLED Devices
Publisher: Wiley
Date: 13-07-2022
Abstract: The proposed concept of aggregation‐induced emission (AIE) has offered an efficient strategy to design high‐performance luminescent materials. Herein, three blue emitters containing a pyrene core decorated with either triphenylamine or tetraphenylethylene units are presented. The designed compounds Py‐TPA and Py‐2TPE are AIE or active materials with blue emission from 464 to 478 nm in the solid state, whereas Py‐2TPA is not. Moreover, the enhanced thermal stability of compounds Py‐TPA and Py‐2TPE allows for their utilization as emitter layers for the fabrication of blue organic light‐emitting diode (OLED) devices. The devices exhibit excellent electroluminescence emission with maximum λ max em in the range 456–482 nm with a maximum external quantum efficiency of 7.27%, high exciton utilization efficiency (77.3%), and low turn‐on voltage (≤3.1 V), as well as low‐efficiency roll‐off. Theoretical calculations reveal that the high exciton utilization efficiency ( ƞ r ) originates from the triplet excitons at T 2 to the lowest single excited (S 1 ) state via a reverse intersystem crossing process following the principle of the “hot exciton” mechanism. This article not only provides powerful evidence revealing the advantages of pyrene‐based AIEgens for OLED applications, but also offers a new approach for designing pyrene‐based “hot exciton” materials for next‐generation OLEDs.
Synchronously Manipulating Absorption and Extinction Coefficient of Semiconducting Polymers via Precise Dual‐Acceptor Engineering for NIR‐II Excited Photothermal Theranostics
Publisher: Wiley
Date: 12-04-2023
Abstract: Integrating the ultralong excitation wavelength, high extinction coefficient, and prominent photothermal conversion ability into a single photothermal agent is an appealing yet significantly challenging task. Herein, a precise dual‐acceptor engineering strategy is exploited for this attempt based on donor‐acceptor (D‐A) type semiconductor polymers by subtly regulating the molar proportions of the two employed electron acceptor moieties featuring different electronic affinity and π‐conjugation degrees, and making full use of the active intramolecular motion‐induced photothermal effect. The optimal polymer SP4 synchronously shows desirable second near‐infrared (NIR‐II) absorption, an extremely high extinction coefficient, and satisfactory photothermal conversion behavior. Consequently, the unprecedented performance of SP4 NPs on 1064 nm laser‐excited photoacoustic imaging (PAI)‐guided photothermal therapy (PTT) is demonstrated by the precise tumor diagnosis and complete tumor elimination.
Sensitive and specific detection of peroxynitrite and in vivo imaging of inflammation by a “simple” AIE bioprobe
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0QM01004A
Abstract: A facile synthesized AIE bioprobe was developed to detect peroxynitrite sensitively and specifically. This bioprobe can realize both in vitro ONOO − detection and in vivo visualization of inflammation.
Aggregation-Induced Emission Nanoparticles for Single Near-Infrared Light-Triggered Photodynamic and Photothermal Antibacterial Therapy
Publisher: American Chemical Society (ACS)
Date: 03-05-2022
Abstract: Phototheranostics is a potential area for precision medicine, which has received increasing attention for antibacterial applications. Integrating all phototheranostic modalities in a single molecule and achieving precise spatial colocalization is a challenging task because of the complexity of energy dissipation and molecular design. Here, a type of quaternary amine functionalized aggregation-induced emission (AIE), AIEgen, was synthesized and used to produce singlet oxygen (
Aggregation-induced emission (AIE)-active polymers for explosive detection
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9PY00322C
Abstract: This review is to summarize the latest progress on aggregation-induced-emission (AIE)-active polymers for explosive detection.
A synergy between the push–pull electronic effect and twisted conformation for high-contrast mechanochromic AIEgens
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0MH01251C
Abstract: ICT-type AIEgens with twisted conformations are ideal candidates for high-contrast mechanochromic luminogens under external force.
Interfacial Assembly and Jamming of Soft Nanoparticle Surfactants into Colloidosomes and Structured Liquids
Publisher: American Chemical Society (ACS)
Date: 28-11-2022
Abstract: Nanoparticle surfactant (NPS) offers a powerful strategy to generate all-liquid constructs that integrate the inherent properties of the NPs into 3D architectures. Here, using the co-assembly of fluorescent polymeric nanoparticles and amine-functionalized polyhedral oligomeric silsesquioxane, the assembly and jamming behavior of a new type of NPS at the oil-water interface is uncovered. Unlike "solid" inorganic nanoparticles, "soft" polymeric nanoparticles can reorganize when jammed, leading to a relaxation and deformation of the interfacial assemblies, for ex le, the 3D printed sugar-coated haw stick-like liquid tubules. With NPS serving as emulsifiers, stable Pickering emulsions are prepared that can be converted into robust colloidosomes with pH responsiveness, showing numerous potential applications for encapsulation and controlled release.
AIEgens/Mitochondria Nanohybrids as Bioactive Microwave Sensitizers for Non‐Thermal Microwave Cancer Therapy
Publisher: Wiley
Date: 17-02-2023
Abstract: Aggregation‐induced emission luminogens (AIEgens) are widely used as photosensitizers for image‐guided photodynamic therapy (PDT). Due to the limited penetration depth of light in biological tissues, the treatments of deep‐seated tumors by visible‐light‐sensitized aggregation‐induced emission (AIE) photosensitizers are severely h ered. Microwave dynamic therapy attracts much attention because microwave irradiation can penetrate very deep tissues and sensitize the photosensitizers to generate reactive oxygen species (ROS). In this work, a mitochondrial‐targeting AIEgen (DCPy) is integrated with living mitochondria to form a bioactive AIE nanohybrid. This nanohybrid can not only generate ROS under microwave irradiation to induce apoptosis of deep‐seated cancer cells but also reprogram the metabolism pathway of cancer cells through retrieving oxidative phosphorylation (OXPHOS) instead of glycolysis to enhance the efficiency of microwave dynamic therapy. This work demonstrates an effective strategy to integrate synthetic AIEgens and natural living organelles, which would inspire more researchers to develop advanced bioactive nanohybrids for cancer synergistic therapy.
All-organic polymeric materials with high refractive index and excellent transparency
Publisher: Springer Science and Business Media LLC
Date: 14-06-2023
DOI: 10.1038/S41467-023-39125-W
Abstract: High refractive index polymers (HRIPs) have drawn attention for their optoelectronic applications and HRIPs with excellent transparency and facile preparation are highly demanded. Herein, sulfur-containing all organic HRIPs with refractive indices up to 1.8433 at 589 nm and excellent optical transparency even in one hundred micrometre scale in the visual and RI region as well as high weight-average molecular weights (up to 44500) are prepared by our developed organobase catalyzed polymerization of bromoalkynes and dithiophenols in yields up to 92%. Notably, the fabricated optical transmission waveguides using the resultant HRIP with the highest refractive index display a reduced propagation loss compared with that generated by the commercial material of SU-8. In addition, the tetraphenylethylene containing polymer not only exhibits a reduced propagation loss, but also is used to examine the uniformity and continuity of optical waveguides with naked eyes because of its aggregation-induced emission feature.
Switching energy dissipation pathway: in situ proton-induced transformation of AIE-active self-assemblies to boost photodynamic therapy
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1BM00044F
Abstract: With the morphological transformation of fluorescent self-assembled nanostructures, their functions can be varied simultaneously.
Enlightening Freeze–Thaw Process of Physically Cross-Linked Poly(vinyl alcohol) Hydrogels by Aggregation-Induced Emission Fluorogens
Publisher: American Chemical Society (ACS)
Date: 29-04-2019
A Brain‐Targeting NIR‐II Ferroptosis System: Effective Visualization and Oncotherapy for Orthotopic Glioblastoma
Publisher: Wiley
Date: 03-03-2023
Abstract: Near‐infrared‐II (NIR‐II) ferroptosis activators offer promising potentials in in vivo theranostics of deep tumors, such as glioma. However, most cases are nonvisual iron‐based systems that are blind for in vivo precise theranostic study. Additionally, the iron species and their associated nonspecific activations might trigger undesired detrimental effects on normal cells. Considering gold (Au) is an essential cofactor for life and it can specifically bind to tumor cells, Au(I)‐based NIR‐II ferroptosis nanoparticles (TBTP‐Au NPs) for brain‐targeted orthotopic glioblastoma theranostics are innovatively constructed. It achieves the real‐time visual monitoring of both the BBB penetration and the glioblastoma targeting processes. Moreover, it is first validated that the released TBTP‐Au specifically activates the effective heme oxygenase‐1‐regulated ferroptosis of glioma cells to greatly extend the survival time of glioma‐bearing mice. This new ferroptosis mechanism based on Au(I) may open a new way for the fabrication of advanced and high‐specificity visual anticancer drugs for clinical trials.
Assembly strategies of organic-based imaging agents for fluorescence and photoacoustic bioimaging applications
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9CS00326F
Abstract: The results of numerous studies have led to the development of assembled organic substances for fluorescence and photoacoustic bioimaging as part of comprehensive approaches to the diagnosis of diseases.
Engineered NIR-II fluorophores with ultralong-distance molecular packing for high-contrast deep lesion identification
Publisher: Springer Science and Business Media LLC
Date: 18-08-2023
DOI: 10.1038/S41467-023-40728-6
Abstract: The limited signal of long-wavelength near-infrared-II (NIR-II, 900–1880 nm) fluorophores and the strong background caused by the diffused photons make high-contrast fluorescence imaging in vivo with deep tissue disturbed still challenging. Here, we develop NIR-II fluorescent small molecules with aggregation-induced emission properties, high brightness, and maximal emission beyond 1200 nm by enhancing electron-donating ability and reducing the donor-acceptor (D-A) distance, to complement the scarce bright long-wavelength emissive organic dyes. The convincing single-crystal evidence of D-A-D molecular structure reveals the strong inhibition of the π-π stacking with ultralong molecular packing distance exceeding 8 Å. The delicately-designed nanofluorophores with bright fluorescent signals extending to 1900 nm match the background-suppressed imaging window, enabling the signal-to-background ratio of the tissue image to reach over 100 with the tissue thickness of ~4–6 mm. In addition, the intraluminal lesions with strong negatively stained can be identified with almost zero background. This method can provide new avenues for future long-wavelength NIR-II molecular design and biomedical imaging of deep and highly scattering tissues.
Nano as a Rosetta Stone: The Global Roles and Opportunities for Nanoscience and Nanotechnology
Publisher: American Chemical Society (ACS)
Date: 22-10-2019
Aggregation‐Induced Emission Luminogens for Direct Exfoliation of 2D Layered Materials in Ethanol
Publisher: Wiley
Date: 09-09-2020
Abstract: Aggregation‐induced emission (AIE) luminogens are an important type of advanced functional materials with fantastic optical properties and have found potential applications in organic electronics, biochemistry, and molecular imaging. Herein, this article presents a novel application of AIE luminogens (AIEgens) for efficient exfoliation of layered transition metal dichalcogenides (TMDs, such as MoS 2 and WSe 2 ). From the 1 H NMR spectroscopic analysis, the designed AIEgens can insert into the space between layers of MoS 2 in ethanol solution and the dynamic molecular rotation against the weak interactions affords large‐scale few‐layer MoS 2 nanosheets (7–8 layers) with enhanced smoothness. The 3D AIEgens play a significant role in preserving the crystal lattice of MoS 2 even at high pressure ( GPa). More importantly, the new approach can also be used for exfoliation of WSe 2 to achieve large‐scale few‐layer nanosheets. The present work thus provides a facile and high yielding synthetic method for accessing on a large scale 2D layered materials with enhanced properties for high‐technology applications.
An acidic pH independent piperazine–TPE AIEgen as a unique bioprobe for lysosome tracing
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7SC03515B
Abstract: PIP–TPE’s fluorescence turns on blue due to the large viscosity of lysosomes which restricts intramolecular motions but it red-shifts in the bulk.
Red-emissive azabenzanthrone derivatives for photodynamic therapy irradiated with ultralow light power density and two-photon imaging
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8SC00633D
Abstract: Azabenzanthrone derivatives with high phototoxicity and efficient emission are designed for photodynamic therapy and deep-tissue imaging.
Deep-Red Fluorescent Organic Nanoparticles with High Brightness and Photostability for Super-Resolution in Vitro and in Vivo Imaging Using STED Nanoscopy
Publisher: American Chemical Society (ACS)
Date: 27-12-2019
Abstract: To achieve super-resolution imaging in biological research using stimulated emission depletion (STED) nanoscopy, organic luminescent materials and their corresponding fluorescent nanoparticles with high brightness and photostability are of great significance. Herein, donor-acceptor-typed DBTBT-4C8 bearing flexible alkyl chains was developed, not only to afford deep-red emission from 600 to 800 nm but also to obtain high fluorescent brightness with the absolute photoluminescence quantum yields of 25%. After that, well-defined and monodispersed spherical nanoparticles using DBTBT-4C8 with bright emission, excellent biocompatibility, and photostability, which can easily mix with hipathic block polymers, were then produced for super-resolution in vitro and in vivo imaging using STED nanoscopy. The observations showed that in contrast to confocal microscopy with a full width at half-maximum (FWHM) value of ≈400 nm, superior resolution with a significantly improved FWHM value of only 100 nm was achieved in biomedical cell imaging, which was also used to reconstruct three-dimensional images of stained HeLa cells at an ultrahigh resolution. More importantly, by using the prepared fluorescent organic nanoparticles (FONPs) in STED nanoscopy, in vivo imaging in glass catfish with largely enhanced resolution was also successfully achieved, demonstrating that these developed deep-red FONPs here are highly suitable for super-resolution in vitro and in vivo imaging using STED nanoscopy.
Fast surface immobilization of native proteins through catalyst-free amino-yne click bioconjugation
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0SC00062K
Abstract: Fast surface immobilization of native bioconjugates through a spontaneous amino-yne click reaction is realized.
Multicomponent Polymerizations of Isocyanides, Aldehydes, and 2-Aminopyridine toward Imidazo[1,2-a]pyridine-Containing Fused Heterocyclic Polymers
Publisher: American Chemical Society (ACS)
Date: 03-10-2022
Utilizing a Pyrazine‐Containing Aggregation‐Induced Emission Luminogen as an Efficient Photosensitizer for Imaging‐Guided Two‐Photon Photodynamic Therapy
Publisher: Wiley
Date: 17-10-2018
Abstract: The development of novel photosensitizers with aggregation-induced emission (AIE) characteristics has aroused tremendous interest, because it could combine efficient bioimaging with precise photodynamic therapy, which would thus dramatically promote applications in biomedical treatment. Among various AIE luminogens (AIEgens), heterocycle-containing molecules are highly promising for this usage because of their high photostability and tunable electronic properties. In this work, a pyrazine-containing AIEgen with a dicyanopyrazine moiety as an electron acceptor and a triphenylamine unit as an electron donor was chosen for study. The V-shaped donor-π-acceptor-π-donor structure of the AIEgen endowed its nanoparticles with excellent nonlinear optical properties for two-photon cell imaging under near-infrared laser excitation. Also, under the same excitation, the nanoparticles could produce reactive oxygen species and further kill the cells efficiently and accurately. The present work thus presents a pyrazine-containing AIEgen as a new photosensitizer for imaging-guided two-photon photodynamic therapy and gives more opportunities for deep-tissue treatment of cancer in future research.
Rapid membrane-specific AIEgen featuring with wash-free imaging and sensitive light-excited killing of cells, bacteria, and fungi
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0QM01046D
Abstract: C6-BD equipped with AIE and ESIPT characteristics was used to visualize the cell membrane with high selectivity, stability, and wash-free operation. It also universal for imaging of bacteria and fungi with light-excited killing via ROS generation.
Aggregation‐Induced Emission: More Is Different
Publisher: Wiley
Date: 25-05-2020
Gelation process visualized by aggregation-induced emission fluorogens
Publisher: Springer Science and Business Media LLC
Date: 23-06-2016
DOI: 10.1038/NCOMMS12033
Abstract: Alkaline-urea aqueous solvent system provides a novel and important approach for the utilization of polysaccharide. As one of the most important polysaccharide, chitosan can be well dissolved in this solvent system, and the resultant hydrogel material possesses unique and excellent properties. Thus the sound understanding of the gelation process is fundamentally important. However, current study of the gelation process is still limited due to the absence of direct observation and the lack of attention on the entire process. Here we show the entire gelation process of chitosan LiOH-urea aqueous system by aggregation-induced emission fluorescent imaging. Accompanied by other pseudo in situ investigations, we propose the mechanism of gelation process, focusing on the formation of junction points including hydrogen bonds and crystalline.
Photo-triggered Zn2+ release for the regulation of zinc enzymes
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0QM00947D
Abstract: A photo-triggered Zn 2+ release system was developed based on HBTH–Zn–TAT NPs, which showed an excellent light-dependent “on–off” performance for Zn 2+ release and the precise regulation of extra- and intracellular zinc enzyme activities.
Functional Polymeric Micromaterials Based on Aggregation‐Induced Emission Luminogens
Publisher: Wiley
Date: 08-09-2023
Frontispiece: A Conjugated Polymeric Supramolecular Network with Aggregation‐Induced Emission Enhancement: An Efficient Light‐Harvesting System with an Ultrahigh Antenna Effect
Publisher: Wiley
Date: 05-06-2020
Facile conversion of water to functional molecules and cross-linked polymeric films with efficient clusteroluminescence
Publisher: Springer Science and Business Media LLC
Date: 30-05-2023
DOI: 10.1038/S41467-023-38769-Y
Abstract: Exploring approaches to utilize abundant water to synthesize functional molecules and polymers with efficient clusteroluminescence properties is highly significant but has yet to be reported. Herein, a chemistry of water and alkyne is developed. The synthesized products are proven as nonaromatic clusteroluminogens that could emit visible light. Their emission colors and luminescent efficiency could be adjusted by manipulating through-space interaction using different starting materials. Besides, the free-standing polymeric films with much high photoluminescence quantum yields (up to 45.7%) are in situ generated via a water-involved interfacial polymerization. The interfacial polymerization-enhanced emission of the polymeric films is observed, where the emission red-shifts and efficiency increases when the polymerization time is prolonged. The synthesized polymeric film is also verified as a Janus film. It exhibits a vapor-triggered reversible mechanical response which could be applied as a smart actuator. Thus, this work develops a method to synthesize clusteroluminogens using water, builds a clear structure-property relationship of clusteroluminogens, and provides a strategy to in situ construct functional water-based polymeric films.
Rational design of red AIEgens with a new core structure from non-emissive heteroaromatics
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8SC02810A
Abstract: This work provides a new strategy to design heterocycle-containing AIEgens from non-emissive heteroaromatics and promotes their applications for long-term lysosome imaging.
Molecular and Aggregate Synergistic Engineering of Aggregation-Induced Emission Luminogens to Manipulate Optical/Electronic Properties for Efficient and Diversified Functions
Publisher: American Chemical Society (ACS)
Date: 19-04-2023
Restriction of molecular motion to a higher level: Towards bright AIE dots for biomedical applications
Publisher: Elsevier BV
Date: 05-2023
Aggregation-Induced Emission Probe for Specific Turn-On Quantification of Soluble Transferrin Receptor: An Important Disease Marker for Iron Deficiency Anemia and Kidney Diseases
Publisher: American Chemical Society (ACS)
Date: 22-12-2018
DOI: 10.1021/ACS.ANALCHEM.7B03694
Abstract: Transferrin receptor (TfR) is overexpressed on the surface of many cancer cells due to its vital roles in iron circulation and cellular respiration. Soluble transferrin receptor (sTfR), a truncated extracellular form of TfR in serum, is an important marker of iron deficiency anemia (IDA) and bone marrow failure in cancer patients. More recently, sTfR level in urine has been related to a specific kidney disease of Henoch-Schönlein purpura nephritis (HSPN). Despite the universal significance of sTfR, there is still a lack of a simple and sensitive method for the quantification of sTfR. Furthermore, it is desirable to have a probe that can detect both TfR and sTfR for further comparison study. In this work, we developed a water-soluble AIE-peptide conjugate with aggregation-induced emission (AIE) characteristics. Taking advantage of the negligible emission from molecularly dissolved tetraphenylethene (TPE), probe TPE-2T7 was used for the light-up detection of sTfR. The probe itself is nonemissive in aqueous solution, but it turns on its fluorescence upon interaction with sTfR to yield a detection limit of 0.27 μg/mL, which is much lower than the sTfR level in IDA patients. Furthermore, a proof-of-concept experiment validates the potential of the probe for diagnosis of HSPN by urine test.
Three‐Pronged Attack by Homologous Far‐red/NIR AIEgens to Achieve 1+1+1>3 Synergistic Enhanced Photodynamic Therapy
Publisher: Wiley
Date: 27-03-2020
Highly Emissive AIEgens with Multiple Functions: Facile Synthesis, Chromism, Specific Lipid Droplet Imaging, Apoptosis Monitoring, and In Vivo Imaging
Publisher: American Chemical Society (ACS)
Date: 02-10-2018
Rapid Biotransformation of Luminescent Bimetallic Nanoparticles in Hepatic Sinusoids
Publisher: American Chemical Society (ACS)
Date: 03-11-2022
DOI: 10.1021/JACS.2C07657
Abstract: Liver sequestration, mainly resulting from the phagocytosis of mononuclear phagocyte system (MPS) cells, is a long-standing barrier in nanoparticle delivery, which severely decreases the disease-targeting ability, leads to nanotoxicity, and inhibits clinical translation. To avoid long-term liver sequestration, we elaborately designed luminescent gold-silver bimetallic nanoparticles that could be rapidly transformed by the hepatic sinusoidal microenvironment rich in glutathione and oxygen, significantly different from monometallic gold nanoparticles that were rapidly sequestrated by Kupffer cells due to the much slower biotransformation. We found that the rapid sinusoidal biotransformation induced by the synergistic reactions of glutathione and oxygen with the reactive silver atoms could help bimetallic nanoparticles to avoid MPS phagocytosis, promote fast release from the liver, prolong blood circulation, enhance renal clearance, and increase disease targeting. With the fast biotransformation in sinusoids, liver sequestration could be turned into a beneficial storage mechanism for nanomedicines to maximize targeting.
Aggregation-induced emission lights up the swelling process: a new technique for swelling characterisation of hydrogels
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9QM00054B
Abstract: The characterization of the swelling properties in hydrogels suffers uncertainty due to the limitations that occur during weight change measurement.
Assembly of 1H-isoindole derivatives by selective carbon–nitrogen triple bond activation: access to aggregation-induced emission fluorophores for lipid droplet imaging
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9SC01035A
Abstract: A method of selectively activating carbon–nitrogen triple bonds has been developed to access 1 H -isoindole AIE fluorophores for lipid droplet imaging.
Aggregation-Induced Emission-Responsive Metal–Organic Frameworks
Publisher: American Chemical Society (ACS)
Date: 21-07-2020
In Situ Electrospinning of Aggregation‐Induced Emission Nanofibrous Dressing for Wound Healing
Publisher: Wiley
Date: 26-02-2022
Abstract: Rapid wound dressing and effective antibacterial therapy that meet the extreme requirements of emergency situations are urgently needed for treating skin wounds. Here, an in situ deposited and personalized nanofibrous dressing is reported which can be directly electrospun on skin wounds by a handheld electrospinning device and perfectly fits different wounds of various sizes. Moreover, an aggregation‐induced emission luminogen with photodynamic therapy effect is loaded in the nanofibrous dressings which endows the dressing's long‐term antibacterial activity during the wound healing process. The in situ electrospun nanofibers show excellent antimicrobial activity against Staphylococcus aureus ( S. aureus ) and methicillin‐resistant Staphylococcus aureus . In vivo studies demonstrate that these antibacterial nanofibrous dressings can effectively reduce inflammation and significantly accelerate wound healing. Such an in situ produced antibacterial dressing is promising as a total solution for treating emergencies, including patient‐specific clinical wounds and military injuries.
Polymorph selectivity of an AIE luminogen under nano-confinement to visualize polymer microstructures
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9SC04239C
Abstract: A polymorphic AIEgen is capable of selective growth in amorphous and crystalline polymer phases with distinct color for microstructure visualization.
Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels
Publisher: Springer Science and Business Media LLC
Date: 09-03-2020
DOI: 10.1038/S41467-020-15095-1
Abstract: Fluorescence imaging in near-infrared IIb (NIR-IIb, 1500–1700 nm) spectrum holds a great promise for tissue imaging. While few inorganic NIR-IIb fluorescent probes have been reported, their organic counterparts are still rarely developed, possibly due to the shortage of efficient materials with long emission wavelength. Herein, we propose a molecular design philosophy to explore pure organic NIR-IIb fluorophores by manipulation of the effects of twisted intramolecular charge transfer and aggregation-induced emission at the molecular and morphological levels. An organic fluorescent dye emitting up to 1600 nm with a quantum yield of 11.5% in the NIR-II region is developed. NIR-IIb fluorescence imaging of blood vessels and deeply-located intestinal tract of live mice based on organic dyes is achieved with high clarity and enhanced signal-to-background ratio. We hope this study will inspire further development on the evolution of pure organic NIR-IIb dyes for bio-imaging.
Stretchable multi-luminescent fibers with AIEgens
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9TC03461G
Abstract: Stretchable multicolor light-emitting fibers were realized by incorporating an ultralow content of AIEgens in polydimethylsiloxane fibers through a continuous dry–wet spinning process for applications in smart textiles.
Aggregation-induced emission: mechanistic study of the clusteroluminescence of tetrathienylethene
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6SC05192H
Abstract: Crystallization induced S⋯S interactions leading to an unusual luminescent phenomenon.
AIE-Active Poly(phenyleneethynylene)s for Fluorescence and Raman Dual-Modal Imaging and Drug-Resistant Bacteria Killing
Publisher: American Chemical Society (ACS)
Date: 15-06-2021
DOI: 10.26434/CHEMRXIV.14776893
Abstract: Poly(phenyleneethynylene) (PPE) is a widely used functional conjugated polymer with applications ranging from organic optoelectronics and fluorescence sensors to optical imaging and theranostics. However, the fluorescence efficiency of PPE in aggregate states is generally not as good as their solution states, which greatly compromises their performance in fluorescence-related applications. Herein, we design and synthesize a series of PPE derivatives with typical aggregation-induced emission (AIE) properties. In these PPEs, the diethylamino-substituted tetraphenylethene units function as the long-wavelength AIE source and the alkyl side chains serve as the functionalization site. The obtained AIE-active PPEs with large π-conjugation show strong aggregate-state fluorescence, interesting self-assembly behaviors, inherently enhanced alkyne vibrations in the Raman-silent region of cells, and efficient antibacterial activities. The PPE nanoparticles with good cellular uptake capability can clearly and sensitively visualize the tumor region and residual tumors via their fluorescence and Raman signals, respectively, to benefit the precise tumor surgery. After post-functionalization, the obtained PPE-based polyelectrolyte can preferentially image bacteria over mammalian cells and possesses efficient photodynamic killing capability against Gram-positive and drug-resistant bacteria. This work provides a feasible design strategy for developing multifunctional conjugated polymers with multimodal imaging capability as well as photodynamic antimicrobial ability.
Aggregation-Induced Emission Probe for Light-Up and in Situ Detection of Calcium Ions at High Concentration
Publisher: American Chemical Society (ACS)
Date: 19-04-2018
Abstract: The fluorescent probe for the detection of calcium ions is an indispensable tool in the biomedical field. The millimolar order of Ca(II) ions is associated with many physiological processes and diseases, such as hypercalcemia, soft tissue calcification, and bone microcracks. However, the conventional fluorescent probes are only suitable for imaging Ca(II) ions in the nanomolar to micromolar range, which can be because of their high affinities toward Ca(II) ions and aggregation-caused quenching drawbacks. To tackle this challenge, we herein develop an aggregation-induced emission (AIE) probe SA-4CO
Organobase-catalysed hydroxyl–yne click polymerization
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0PY00095G
Abstract: An efficient organobase (DABCO)-catalysed hydroxyl–yne click polymerization is successfully developed under mild conditions.
Unique interplay between Zn2+ and nZnO determined the dynamic cellular stress in zebrafish cells
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1EN00146A
Abstract: Nano-ZnO with low extracellular dissolution stimulates high lysosomal accumulation and ROS production and exhibits greater cytotoxicity than dissolved Zn 2+ .
Pre-Folded G-Quadruplex as a Tunable Reporter to Facilitate CRISPR/Cas12a-Based Visual Nucleic Acid Diagnosis
Publisher: American Chemical Society (ACS)
Date: 18-11-2022
DOI: 10.1021/ACSSENSORS.2C01391
Abstract: Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas12a-based detection strategies with a fluorophore quencher-labeled ssDNA reporter or gold nanoparticle ssDNA reporter have been widely used in point-of-care (POC) molecular diagnostics. However, the potential of these CRISPR/Cas12a strategies for POC molecular diagnostics is often compromised due to the complex labeling, high cost, and low signal-to-noise ratio. Herein, we show a pre-folded G-quadruplex (G4) structure with tunable tolerance to CRISPR/Cas12a trans-cleavage and explore its mechanism. Two G4 structures (i.e., Tel22-10 and G16C) sensitive or tolerant to CRISPR/Cas12a trans-cleavage are designed and used as signal elements to fabricate a label-free visible fluorescent strategy or "signal-on" colorimetric strategy, respectively. These two strategies facilitate an ultrasensitive visual nucleic acid determination of Group B
Direct Visualization of Chiral Amplification of Chiral Aggregation Induced Emission Molecules in Nematic Liquid Crystals
Publisher: American Chemical Society (ACS)
Date: 04-03-2021
Through-Space Conjugated Molecule with Dual Delayed Fluorescence and Room-Temperature Phosphorescence for High-Performance OLEDs
Publisher: American Chemical Society (ACS)
Date: 30-01-2023
9,10-Phenanthrenequinone: A Promising Kernel to Develop Multifunctional Antitumor Systems for Efficient Type I Photodynamic and Photothermal Synergistic Therapy
Publisher: American Chemical Society (ACS)
Date: 30-11-2021
Abstract: Synergistic phototherapy provides a promising strategy to conquer the hypoxia and heterogeneity of tumors and realize a better therapeutic effect than monomodal photodynamic therapy (PDT) or photothermal therapy (PTT). The development of efficient multifunctional organic phototheranostic systems still remains a challenging task. Herein, 9,10-phenanthrenequinone (PQ) with strong electron-withdrawing ability is conjugated with the rotor-type electron-donating triphenylamine derivatives to create a series of tailor-made photosensitizers. The highly efficient Type I reactive oxygen species generation and outstanding photothermal conversion capacity are tactfully integrated into these PQ-cored photosensitizers. The underlying photophysical and photochemical mechanisms of the combined photothermal and Type I photodynamic effects are deciphered by experimental and theoretical methods and are closely associated with the active intramolecular bond stretching vibration, facilitated intersystem crossing, and specific redox cycling activity of the PQ core. Both
Quantitative Imaging of Lipid Synthesis and Lipolysis Dynamics in Caenorhabditis elegans by Stimulated Raman Scattering Microscopy
Publisher: American Chemical Society (ACS)
Date: 27-12-2018
DOI: 10.1021/ACS.ANALCHEM.8B04875
Abstract: Quantitative methods to precisely measure cellular states in vivo have become increasingly important and desirable in modern biology. Recently, stimulated Raman scattering (SRS) microscopy has emerged as a powerful tool to visualize small biological molecules tagged with alkyne (C≡C) or carbon-deuterium (C-D) bonds in the cell-silent region. In this study, we developed a technique based on SRS microscopy of vibrational tags for quantitative imaging of lipid synthesis and lipolysis in live animals. The technique aims to overcome the major limitations of conventional fluorescent staining and lipid extraction methods that do not provide the capability of in vivo quantitative analysis. Specifically, we used three bioorthogonal lipid molecules (the alkyne-tagged fatty acid 17-ODYA, deuterium-labeled saturated fatty acid PA-D
Solvatochromic Near-Infrared Aggregation-Induced Emission-Active Acrylonitriles by Acceptor Modulation for Low-Power Stimulated Emission Depletion Nanoscopy
Publisher: American Chemical Society (ACS)
Date: 24-02-2023
Click-Reaction-Mediated Chemotherapy and Photothermal Therapy Synergistically Inhibit Breast Cancer in Mice
Publisher: American Chemical Society (ACS)
Date: 24-07-2023
Bioinspired Supramolecular Nanotoroids with Aggregation-Induced Emission Characteristics
Publisher: American Chemical Society (ACS)
Date: 12-08-2022
Abstract: Supramolecular toroids have attracted continuous attention because of their fascinating topological structure and important role in biological systems. However, it still remains a great challenge to construct supramolecular functional toroids and clarify the formation mechanism. Herein, we develop a strategy to prepare supramolecular helical fluorescent nanotoroids by cooperative self-assembly of an amino acid and a dendritic hiphile (AIE-den-1) with aggregation-induced emission characteristics. Mechanistic investigation on the basis of fluorescence and circular dichroism analyses suggests that the toroid formation can be driven by the interactions of AIE-den-1 with amino acid and goes through a topological morphology transformation from nanofibers to left-handed nanotoroids by means of a twist-fused-loop process.
Celebration of the 20th anniversary of aggregation-induced emission with research highlights from Royal Society of Chemistry journals
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0TC90119A
Abstract: Fengyan Song, Bin Liu and Ben Zhong Tang introduce the celebration of the 20th anniversary of aggregation-induced emission with research highlights from Royal Society of Chemistry journals.
Functionalization of Silk by AIEgens through Facile Bioconjugation: Full‐Color Fluorescence and Long‐Term Bioimaging
Publisher: Wiley
Date: 28-04-2021
Leveraging bacterial survival mechanism for targeting and photodynamic inactivation of bacterial biofilms with red natural AIEgen
Publisher: Elsevier BV
Date: 03-2022
Planarized intramolecular charge transfer on triphenylamine-modified pyrazine and its application in organic light-emitting diodes
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0TC00626B
Abstract: PLICT molecules have twisted structures in the ground state, which are conducive to transport, while the planar conformations of the excited states facilitate radiation. Based on these advantages, they can serve as excellent emitters and hosts in OLEDs.
A Sensitive and Reliable Organic Fluorescent Nanothermometer for Noninvasive Temperature Sensing
Publisher: American Chemical Society (ACS)
Date: 21-07-2021
DOI: 10.1021/JACS.1C04597
An Easily Available Ratiometric Reaction-Based AIE Probe for Carbon Monoxide Light-up Imaging
Publisher: American Chemical Society (ACS)
Date: 18-07-2019
DOI: 10.1021/ACS.ANALCHEM.9B02691
Abstract: Carbon monoxide (CO) is a significant gasotransmitter that naturally modulates inflammatory responses. Visualization of CO
Benzyne–azide polycycloaddition: a facile route toward functional polybenzotriazoles
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9PY00632J
Abstract: An efficient benzyne–azide polycycloaddition is established and functional poly(benzotriazole)s are produced under mild reaction conditions.
Building a stable cationic molecule/electrode interface for highly efficient and durable CO2 reduction at an industrially relevant current
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0EE02535F
Abstract: Effective electronic induction and a stable interface collectively contribute to industrially relevant CO 2 reduction performance in a flow cell.
Real‐Time and High‐Resolution Bioimaging with Bright Aggregation‐Induced Emission Dots in Short‐Wave Infrared Region
Publisher: Wiley
Date: 17-01-2018
Abstract: Fluorescence imaging in the spectral region beyond the conventional near-infrared biological window (700-900 nm) can theoretically afford high resolution and deep tissue penetration. Although some efforts have been devoted to developing a short-wave infrared (SWIR 900-1700 nm) imaging modality in the past decade, long-wavelength biomedical imaging is still suboptimal owing to the unsatisfactory materials properties of SWIR fluorophores. Taking advantage of organic dots based on an aggregation-induced emission luminogen (AIEgen), herein microscopic vasculature imaging of brain and tumor is reported in living mice in the SWIR spectral region. The long-wavelength emission of AIE dots with certain brightness facilitates resolving brain capillaries with high spatial resolution (≈3 µm) and deep penetration (800 µm). Owning to the deep penetration depth and real-time imaging capability, in vivo SWIR microscopic angiography exhibits superior resolution in monitoring blood-brain barrier damage in mouse brain, and visualizing enhanced permeability and retention effect in tumor sites. Furthermore, the AIE dots show good biocompatibility, and no noticeable abnormalities, inflammations or lesions are observed in the main organs of the mice. This work will inspire new insights on development of advanced SWIR techniques for biomedical imaging.
Multiple Anti‐Counterfeiting Guarantees from a Simple Tetraphenylethylene Derivative – High‐Contrasted and Multi‐State Mechanochromism and Photochromism
Publisher: Wiley
Date: 22-10-2019
Through-Space Interaction of Tetraphenylethylene: What, Where, and How
Publisher: American Chemical Society (ACS)
Date: 21-04-2022
DOI: 10.1021/JACS.2C02381
Abstract: Electronic conjugation through covalent bonds is generally considered as the basis for the electronic transition of organic luminescent materials. Tetraphenylethylene (TPE), an efficient fluorophore with aggregation-induced emission character, fluoresces blue emission in the aggregate state, and such photoluminescence is always ascribed to the through-bond conjugation (TBC) among the four phenyl rings and the central C═C bond. However, in this work, systematic spectroscopic studies and DFT theoretical simulation reveal that the intramolecular through-space interaction (TSI) between two vicinal phenyl rings generates the bright blue emission in TPE but not the TBC effect. Furthermore, the evaluation of excited-state decay dynamics suggests the significance of photoinduced isomerization in the nonradiative decay of TPE in the solution state. More importantly, different from the traditional qualitative description for TSI, the quantitative elucidation of the TSI is realized through the atoms-in-molecules analysis meanwhile, a theoretical solid-state model for TPE and other multirotor systems for studying the electronic configuration is preliminarily established. The mechanistic model of TSI delineated in this work provides a new strategy to design luminescent materials beyond the traditional theory of TBC and expands the quantum understanding of molecular behavior to the aggregate level.
Phage-Guided Targeting, Discriminative Imaging, and Synergistic Killing of Bacteria by AIE Bioconjugates
Publisher: American Chemical Society (ACS)
Date: 30-01-2020
DOI: 10.1021/JACS.9B12936
Abstract: New agents with particular specificity toward targeted bacteria and superefficacy in antibacterial activity are urgently needed in facing the crisis of worldwide antibiotic resistance. Herein, a novel strategy by equipping bacteriophage (PAP) with photodynamic inactivation (PDI)-active AIEgens (luminogens with aggregation-induced emission property) was presented to generate a type of AIE-PAP bioconjugate with superior capability for both targeted imaging and synergistic killing of certain species of bacteria. The targeting ability inherited from the bacteriophage enabled the bioconjugates to specifically recognize the host bacteria with preserved infection activity of phage itself. Meanwhile, the AIE characteristic empowered them a monitoring functionality, and the real-time tracking of their interactions with targets was therefore realized via convenient fluorescence imaging. More importantly, the PDI-active AIEgens could serve as powerful in situ photosensitizers producing high-efficiency reactive oxygen species (ROS) under white light irradiation. As a result, selective targeting and synergistic killing of both antibiotic-sensitive and multi-drug-resistant (MDR) bacteria were successfully achieved in in vitro and in vivo antibacterial tests with excellent biocompatibility. This novel AIE-phage integrated strategy would ersify the existing pool of antibacterial agents and inspire the development of promising drug candidates in the future.
A lipophilic AIEgen for lipid droplet imaging and evaluation of the efficacy of HIF-1 targeting drugs
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9TB02848J
Abstract: A lipid-droplet-specific AIEgen was used to evaluate the inhibitory efficacy of HIF-1-targeting drugs by assessing lipid-droplet levels.
Ultrasensitive, Fast-Responsive, Directional Airflow Sensing by Bioinspired Suspended Graphene Fibers
Publisher: American Chemical Society (ACS)
Date: 09-01-2023
Sailing with young investigators on a sea of stars
Publisher: Wiley
Date: 12-2022
DOI: 10.1002/AGT2.307
An Ultraviolet Fluorophore with Narrowed Emission via Coplanar Molecular Strategy
Publisher: Wiley
Date: 26-10-2022
Abstract: Narrowband emitting fluorophores exhibit immense potentials for organic light‐emitting diodes (OLEDs) with high color purity. However, it's still hard to simultaneously realize short‐wavelength ultraviolet (UV) or near ultraviolet emission (NUV) while maintaining a narrowed full width at half maximum (FWHM) value, and rare work focus on such challenging pursuit. Herein, an ingenious synthetic method was devised to achieve emitters with coplanar structure. 11‐(4,6‐diphenyl‐1,3,5‐triazin‐2‐yl)indolo[3,2,1‐ jk ]carbazole (ICZ‐TAZ) was designed to realize narrowed UV emission both in photoluminescence (PL) and electroluminescence (EL) which benefited from the suppression of vibronic coupling. UV/NUV OLEDs based on ICZ‐TAZ achieve external quantum efficiency (EQE) maximums of 3.26 % peaks @ 388 nm and 4.02 % peaks @ 406 nm with small FWHM of 32 nm and 46 nm, respectively, corresponding with reduced efficiency roll‐off at luminance of 100 cd m −2 .
Pillar[5]arene‐Modified Gold Nanorods as Nanocarriers for Multi‐Modal Imaging‐Guided Synergistic Photodynamic‐Photothermal Therapy
Publisher: Wiley
Date: 18-03-2021
Abstract: Supramolecular approaches have opened up vast possibilities to construct versatile materials, especially those with stimuli‐responsiveness and integrated functionalities of multi‐modal diagnosis and synergistic therapeutics. In this study, a hybrid theranostic nanosystem named TTPY‐Py⊂CP5@AuNR is constructed via facile host–guest interactions, where TTPY‐Py is a photosensitizer with aggregation‐induced emission and CP5@AuNR represents the carboxylatopillar[5]arene (CP5)‐modified Au nanorods. TTPY‐Py⊂CP5@AuNR integrates the respective advantages of TTPY‐Py and CP5@AuNR such as the high performance of reactive oxygen species generation and photothermal conversion, and meanwhile shows fluorescence responses to both temperature and pH stimuli. The successful modification of CP5 macrocycles on AuNRs surfaces can eliminate the cytotoxicity of AuNRs and enable them to serve as the nanocarrier of TTPY‐Py for further theranostic applications. Significantly, in vitro and in vivo evaluations demonstrate that this supramolecular nanotheranostic system possesses multiple modalities including intensive fluorescence imaging (FLI), photoacoustic imaging (PAI), efficient photodynamic therapy (PDT), and photothermal therapy (PTT), indicating its great potential for FLI‐PAI imaging‐guided synergistic PDT‐PTT therapy. Moreover, TTPY‐Py can be released upon activation by the acidic environment of lysosomes and then specifically light up mitochondria. This study demonstrates a new strategy for the design of versatile nanotheranostics for accurate tumor imaging and cancer therapies.
Heavy Atom Effect of Bromine Significantly Enhances Exciton Utilization of Delayed Fluorescence Luminogens
Publisher: American Chemical Society (ACS)
Date: 03-05-2018
Abstract: Raising triplet exciton utilization of pure organic luminescent materials is of significant importance for efficiency advancement of organic light-emitting diodes (OLEDs). Herein, by introducing bromine atom(s) onto a typical molecule (bis(carbazol-9-yl)-4,5-dicyanobenzene) with thermally activated delayed fluorescence, we demonstrate that the heavy atom effect of bromine can increase spin-orbit coupling and promote the reverse intersystem crossing, which endow the molecules with more distinct delayed fluorescence. In consequence, the triplet exciton utilization is improved greatly with the increase of bromine atoms, affording apparently advanced external quantum efficiencies of OLEDs. Utilizing the enhancement effect of bromine atoms on delayed fluorescence should be a simple and promising design concept for efficient organic luminogens with high exciton utilization.
Unveiling the crucial contributions of electrostatic and dispersion interactions to the ultralong room-temperature phosphorescence of H-bond crosslinked poly(vinyl alcohol) films
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1MH01829A
Abstract: We present a facile strategy to activate ultralong RTP emissions of organic phosphors doped into H-bond crosslinked PVA films. The longest RTP lifetime of 1.74 s is obtained by tailoring the electrostatic and dispersion interactions.
Powerful Synergy of Traditional Chinese Medicine and Aggregation-Induced Emission-Active Photosensitizer in Photodynamic Therapy
Publisher: American Chemical Society (ACS)
Date: 20-09-2023
Mitochondria‐Targeting Phototheranostics by Aggregation‐Induced NIR‐II Emission Luminogens: Modulating Intramolecular Motion by Electron Acceptor Engineering for Multi‐Modal Synergistic Therapy
Publisher: Wiley
Date: 10-01-2022
Abstract: Phototheranostic agents have thrived as promising tools for cancer theranostics because of the integration of sensitive in situ fluorescence imaging and effective multi‐model synergistic therapy. However, how to manipulate the intangible photon energy transfer to balance the competitive radiative and nonradiative processes is still challenging. Although numerous phototheranostic molecules are reported, their complicated molecular design and tedious synthesis often stumble further their development. Herein, three simple molecules with electron donating−accepting structures are developed. The electron acceptor engineering on molecules by introducing acridinium unit gives rise to TPEDCAc with aggregation‐induced second near‐infrared emission (AIE NIR‐II), high reactive oxygen species generation capability, and excellent photothermal conversion efficiency (44.8%) due to the drastic intramolecular motion of large acridinium rotor and balanced AIE effect. Experimental analysis and calculation on the controlled molecules suggested that large torsional angle and the strong electron‐withdrawing ability of the acridinium unit are keys for NIR‐II emission and balanced photodynamic hotothermal conversion. Impressively, the positively charged TPEDCAc shows mitochondria‐targeting capability and high performance in in vivo multi‐modal cancer theranostics under NIR laser irradiation. Hence, this work not only provides a single NIR‐II AIE‐based multi‐modal cancer theranostic system but inspires new insights into future development of new theranostic platforms.
ACQ‐to‐AIE Transformation: Tuning Molecular Packing by Regioisomerization for Two‐Photon NIR Bioimaging
Publisher: Wiley
Date: 04-06-2020
Oxidization enhances type I ROS generation of AIE-active zwitterionic photosensitizers for photodynamic killing of drug-resistant bacteria
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3SC00980G
Abstract: An efficient type I zwitterionic photosensitizer MPD-O was constructed by an oxidization strategy, providing a new guideline for the development of AIE-active type I photosensitizers.
Photo-thermo-induced room-temperature phosphorescence through solid-state molecular motion
Publisher: Springer Science and Business Media LLC
Date: 06-07-2022
DOI: 10.1038/S41467-022-31481-3
Abstract: The development of smart-responsive materials, in particular those with non-invasive, rapid responsive phosphorescence, is highly desirable but has rarely been described. Herein, we designed and prepared a series of molecular rotors containing a triazine core and three bromobiphenyl units: o -Br-TRZ, m -Br-TRZ, and p -Br-TRZ. The bromine and triazine moieties serve as room temperature phosphorescence-active units, and the bromobiphenyl units serve as rotors to drive intramolecular rotation. When irradiated with strong ultraviolet photoirradiation, intramolecular rotations of o -Br-TRZ, m -Br-TRZ, and p -Br-TRZ increase, successively resulting in a photothermal effect via molecular motions. Impressively, the photothermal temperature attained by p -Br-TRZ is as high as 102 °C, and synchronously triggers its phosphorescence due to the ordered molecular arrangement after molecular motion. The thermal effect is expected to be important for triggering efficient phosphorescence, and the photon input for providing a precise and non-invasive stimulus. Such sequential photo-thermo-phosphorescence conversion is anticipated to unlock a new stimulus-responsive phosphorescence material without chemicals invasion.
Double‐pronged Antimicrobial Agents based on a Donor‐π‐Acceptor Type Aggregation‐Induced Emission Luminogen
Publisher: Wiley
Date: 20-10-2022
Abstract: Novel antibacterial agents are urgently needed to control the infections induced by multidrug‐resistant (MDR) bacteria. Herein, we rationally designed and facilely synthesized a new D‐π‐A type luminogen with strong red/near‐infrared fluorescence emission, great aggregation‐induced emission (AIE) features, and excellent reactive oxygen species (ROS) production. The newly developed molecule TTTh killed the methicillin‐resistant Staphylococcus aureus (MRSA) by triggering the ROS accumulation in bacteria and interrupting the membrane integrity. Moreover, TTTh specifically targeted the lysosomes and potentiated their maturation to accelerate the clearance of intracellular bacteria. Additionally, reduced bacterial burden and improved healing were observed in TTTh‐treated wounds with negligible side effects. Our study expands the biological design and application of AIE luminogens (AIEgens), and provides new insights into discovering novel antibacterial targets and agents.
Hierarchical Supramolecular Self‐Assembly: Fabrication and Visualization of Multiblock Microstructures**
Publisher: Wiley
Date: 02-11-2022
Abstract: Due to the fast dynamics and re‐equilibration of supramolecular self‐assembly, bottom‐up molecular strategies to fabricate well‐defined and controllable multiblock structures are rare. Herein, we propose a new concept for fabrication of fluorescent multiblock microcolumns containing 1 to 7 blocks via hierarchical supramolecular self‐assembly based on cucurbit[8]uril (CB[8]), NaBr and an AIEgen guest. Through the complexation between CB[8] and different numbers of AIEgen guests (2, 1, 0), the competitive displacement caused by the binding of the sodium cation to the CB[8] portal, and the reversible assembly of positively charged guests in salt solutions, one‐pot hierarchical supramolecular self‐assembly is realized. The molecular structure of each block is analyzed by single‐crystal X‐ray diffraction. The AIEgen enables the self‐assembly of multiblocks to be visualized, understood, and regulated.
Boosting Cyanobacteria Growth by Fivefold with Aggregation-Induced Emission Luminogens: Toward the Development of a Biofactory
Publisher: American Chemical Society (ACS)
Date: 03-11-2021
Recent advances of luminogens with aggregation-induced emission in multi-photon theranostics
Publisher: AIP Publishing
Date: 12-2021
DOI: 10.1063/5.0071142
Abstract: Multi-photon theranostics, involving the absorption of two or three photons by luminogens, has come to occupy an important place in biomedical research, with its ability to allow real-time observation/treatment of dynamic structures in living cells and organisms. Luminogens with aggregation-induced emission characteristics are recognized as perfect candidates for multi-photon agents, owing to their flexibility of design, resistance to photobleaching, robust stability, and reduced cytotoxicity. Hence, in recent years, significant breakthroughs in design and application of such luminogens have been reported. In this review, we summarize the latest advances in molecular guidelines and photophysical process control for developing luminogens with large multi-photon action cross section. Special attention is paid to how the molecular structure and intermolecular interactions influence the intramolecular charge transfer, and how new strategies have been developed to advance the multi-photon imaging and therapeutic performance. With this review, we hope to encourage further exploitation of luminogens with aggregation-induced emission characteristics to advance multi-photon theranostics.
Complete deciphering of the dynamic stereostructures of a single aggregation-induced emission molecule
Publisher: Elsevier BV
Date: 04-2022
Janus luminogens with bended intramolecular charge transfer: Toward molecular transistor and brain imaging
Publisher: Elsevier BV
Date: 10-2021
Highly Selective and Productive Synthesis of a Carbon Dioxide-Based Copolymer upon Zwitterionic Growth
Publisher: American Chemical Society (ACS)
Date: 28-01-2021
Brain‐Targeted Aggregation‐Induced‐Emission Nanoparticles with Near‐Infrared Imaging at 1550 nm Boosts Orthotopic Glioblastoma Theranostics
Publisher: Wiley
Date: 19-12-2021
Abstract: A remaining challenge in the treatment of glioblastoma multiforme (GBM) is surmounting the blood–brain barrier (BBB). Such a challenge prevents the development of efficient theranostic approaches that combine reliable diagnosis with targeted therapy. In this study, brain‐targeted near‐infrared IIb (NIR‐IIb) aggregation‐induced‐emission (AIE) nanoparticles are developed via rational design, which involves twisting the planar molecular backbone with steric hindrance. The resulting nanoparticles can balance competing responsiveness demands for radiation‐mediated NIR fluorescence imaging at 1550 nm and non‐radiation NIR photothermal therapy (NIR‐PTT). The brain‐targeting peptide apolipoprotein E peptide (ApoE) is grafted onto these nanoparticles (termed as ApoE‐Ph NPs) to target glioma and promote efficient BBB traversal. A long imaging wavelength 1550 nm band‐pass filter is utilized to monitor the in vivo biodistribution and accumulation of the nanoparticles in a model of orthotopic glioma, which overcomes previous limitations in wavelength range and equipment. The results demonstrate that the ApoE‐Ph NPs have a higher PTT efficiency and significantly enhanced survival of mice bearing orthotopic GBM with moderate irradiation (0.5 W cm −2 ). Collectively, the work highlights the smart design of a brain‐targeted NIR‐II AIE theranostic approach that opens new diagnosis and treatment options in the photonic therapy of GBM.
Deciphering the working mechanism of aggregation-induced emission of tetraphenylethylene derivatives by ultrafast spectroscopy
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8SC01170B
Abstract: Photocyclized intermediate formation and quasi CC twisting are the dominant processes behind the AIE.
Aggregation-induced emission luminogens for image-guided surgery in non-human primates
Publisher: Springer Science and Business Media LLC
Date: 10-11-2021
DOI: 10.1038/S41467-021-26417-2
Abstract: During the past two decades, aggregation-induced emission luminogens (AIEgens) have been intensively exploited for biological and biomedical applications. Although a series of investigations have been performed in non-primate animal models, there is few pilot studies in non-human primate animal models, strongly hindering the clinical translation of AIE luminogens (AIEgens). Herein, we present a systemic and multifaceted demonstration of an optical imaging-guided surgical operation via AIEgens from small animals (e.g., mice and rabbits) to rhesus macaque, the typical non-human primate animal model. Specifically, the folic conjugated-AIE luminogen (folic-AIEgen) generates strong and stable fluorescence for the detection and surgical excision of sentinel lymph nodes (SLNs). Moreover, with the superior tumor/normal tissue ratio and rapid tumor accumulation, folic-AIEgen successfully images and guides the precise resection of invisible cancerous metastases. Taken together, the presented strategies of folic-AIEgen based fluorescence intraoperative imaging and visualization-guided surgery show potential for clinical applications.
2,5-bis(4-alkoxycarbonylphenyl)-1,4-diaryl-1,4-dihydropyrrolo[3,2-b]pyrrole (AAPP) AIEgens: tunable RIR and TICT characteristics and their multifunctional applications
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7SC03076B
Abstract: Novel propeller-like AIEgens with tunable emission were readily prepared and used as a fluorescent thermometer and selective chemosensor for Cd( ii ) detection.
Organometallic AIEgens for biological theranostics
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0QM01130D
Abstract: The marriage of AIEgens and organometallic complexes has shown great potential in biological probes and photosensitizers.
BioAIEgens derived from rosin: how does molecular motion affect their photophysical processes in solid state?
Publisher: Springer Science and Business Media LLC
Date: 19-03-2021
DOI: 10.1038/S41467-021-22061-Y
Abstract: The exploration of artificial luminogens with bright emission has been fully developed with the advancement of synthetic chemistry. However, many of them face problems like weakened emission in the aggregated state as well as poor renewability and sustainability. Therefore, the development of renewable and sustainable luminogens with anti-quenching function in the solid state, as well as to unveil the key factors that influence their luminescence behavior become highly significant. Herein, a new class of natural rosin-derived luminogens with aggregation-induced emission property (AIEgens) have been facilely obtained with good biocompatibility and targeted organelle imaging capability as well as photochromic behavior in the solid state. Mechanistic study indicates that the introduction of the alicyclic moiety helps suppress the excited-state molecular motion to enhance the solid-state emission. The current work fundamentally elucidates the role of alicyclic moiety in luminogen design and practically demonstrates a new source to large-scalely obtain biocompatible AIEgens.
Unveiling the Different Emission Behavior of Polytriazoles Constructed from Pyrazine-Based AIE Monomers by Click Polymerization
Publisher: American Chemical Society (ACS)
Date: 07-03-2018
Abstract: Polymers with aggregation-induced emission (AIE) characteristics have aroused tremendous interest because of their potential applications in large-area flexible display and luminescent self-assembling, and as stimuli-responsive and porous materials. However, the design of AIE-active polymers is always not as easy as that of small molecules because their properties are hard to predict. In some cases, the polymers prepared from the AIE-active monomers show the aggregation-caused quenching (ACQ) instead of AIE effect. To understand the structure-property relationship of the polymers constructed from the AIE monomers, in this paper, two pyrazine-containing AIE monomers were utilized to construct luminescent polymers by click polymerization. The photophysical property investigation indicates that the polytriazole containing tetraphenylpyrazine units is AIE-active, whereas that bearing 2,3-dicyano-5,6-diphenylpyrazine units suffers from the ACQ effect. Through systematical investigation, the cause for such difference was unveiled. Thus, this work provides a useful guidance for further design of AIE-active polymers.
Facile Conversion of Water to Functional Molecules and Interfacial Polymers with Efficient Clusteroluminescence
Publisher: Research Square Platform LLC
Date: 17-01-2023
DOI: 10.21203/RS.3.RS-2465343/V1
Abstract: Water is always used by nature to construct complex species. Learning from nature, the exploration of artificial approaches to utilize abundant water to synthesize functional molecules and polymers with efficient clusteroluminescence properties (CLgens) is highly significant but has yet to be reported. Herein, a new chemistry of water and alkyne was developed. The synthesized products were proved as nonaromatic CLgens that could emit visible light. Their emission colors and luminescent efficiency could be adjusted by manipulating through-space interaction via using different water and alkyne. Besides, the free-standing polymeric films with much high photoluminescence quantum yields (up to 45.7%) were in situ generated via a new H 2 O-involved interfacial polymerization. The interfacial polymerization-induced emission of the polymeric films was observed, where the emission red-shifted and efficiency increased when the polymerization time was prolonged. The synthesized polymeric film was also verified as a "Janus film". It exhibits a vapor-triggered reversible mechanical response which could be applied as a smart actuator. Thus, this work develops a new method to synthesize CLgens using water, builds a clear structure-property relationship of CLgens, and provides a novel strategy to in situ construct functional H 2 O-based polymeric films.
Polymeric nanorods with aggregation-induced emission characteristics for enhanced cancer targeting and imaging
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7NR09196F
Abstract: Bright polymeric AIE nanorods with higher tumor accumulation and more efficient tumor cell uptake are reported for enhanced cancer imaging.
Why Do Simple Molecules with “Isolated” Phenyl Rings Emit Visible Light?
Publisher: American Chemical Society (ACS)
Date: 03-11-2017
DOI: 10.1021/JACS.7B08592
Abstract: π-Bonds connected with aromatic rings were generally believed as the standard structures for constructing highly efficient fluorophores. Materials without these typical structures, however, exhibited only low fluorescence quantum yields and emitted in the ultraviolet spectral region. In this work, three molecules, namely bis(2,4,5-trimethylphenyl)methane, 1,1,2,2-tetrakis(2,4,5-trimethylphenyl)ethane, and 1,1,2,2-tetraphenylethane, with nonconjugated structures and isolated phenyl rings were synthesized and their photophysical properties were systematically investigated. Interestingly, the emission spectra of these three molecules could be well extended to 600 nm with high solid-state quantum yields of up to 70%. Experimental and theoretical analyses proved that intramolecular through-space conjugation between the "isolated" phenyl rings played an important role for this abnormal phenomenon.
Dynamic Visualization of Stress/Strain Distribution and Fatigue Crack Propagation by an Organic Mechanoresponsive AIE Luminogen
Publisher: Wiley
Date: 10-09-2018
Abstract: Stress exists ubiquitously and is critically important for the manufacturing industry. Due to the ultrasensitive mechanoresponse of the emission of 1,1,2,2,-tetrakis(4-nitrophenyl)ethane (TPE-4N), a luminogen with aggregation-induced emission characteristics, the visualization of stress/strain distributions on metal specimens with a pure organic fluorescent material is achieved. Such a fluorescence mapping method enjoys the merits of simple setup, real-time, full-field, on-site, and direct visualization. Surface analysis shows that TPE-4N can form a nonfluorescent, crystalline uniform film on the metal surface, which cracks into fluorescent amorphous fragments upon mechanical force. Therefore, the invisible information of the stress/strain distribution of the metal specimens are transformed to visible fluorescent signals, which generally matches well but provides more details than software simulation. Remarkably, fatigue crack propagation in stainless steel and aluminum alloy can be observed and predicted clearly, further demonstrating the ultrasensitivity and practicability of TPE-4N.
Designing Efficient and Ultralong Pure Organic Room‐Temperature Phosphorescent Materials by Structural Isomerism
Publisher: Wiley
Date: 04-06-2018
Abstract: Pure organic materials with ultralong room-temperature phosphorescence (RTP) are attractive alternatives to inorganic phosphors. However, they generally show inefficient intersystem crossing (ISC) owing to weak spin-orbit coupling (SOC). A design principle based on the realization of small energy gap between the lowest singlet and triplet states (ΔE
Aggregation-Induced Emission Probe for Study of the Bactericidal Mechanism of Antimicrobial Peptides
Publisher: American Chemical Society (ACS)
Date: 22-03-2018
Abstract: Multidrug resistant bacterial infection has become one of the most serious threats to human health. Antimicrobial peptides (AMPs) have been identified as potential alternatives to antibiotics owing to their excellent bactericidal activity. However, the complicated bactericidal mechanism of AMPs is still poorly understood. Fluorescence imaging has many advantages in terms of dynamic monitoring, easy operation, and high sensitivity. In this study, we developed an aggregation-induced emission (AIE)-active probe AMP-2HBT by decorating the antimicrobial peptide HHC36 (KRWWKWWRR) with an AIEgen of 2-(2-hydroxyphenyl)benzothiazole (HBT). This AIE-active probe exhibited an excellent light-up fluorescence after binding with bacteria, enabling a real-time monitoring of the binding process. Moreover, a similar time-dependent bactericidal kinetics was observed for the AIE-active probe and HHC36 peptide, which indicated that the bactericidal activity of the peptide was not compromised by decorating with the AIEgen. The bactericidal mechanism of HHC36 peptide was further investigated by super-resolution fluorescence microscopy, transmission electron microscopy (TEM), and scanning electron microscopy (SEM), which suggested that the probe tended to accumulate on the bacterial membrane and efficiently disrupt the membrane structure to kill both Gram-positive and -negative bacteria. This AIE-active probe thus provided a convenient tool to investigate the bactericidal mechanism of AMPs.
In Vivo Aggregation of Clearable Bimetallic Nanoparticles with Interlocked Surface Motifs for Cancer Therapeutics Amplification
Publisher: American Chemical Society (ACS)
Date: 10-08-2023
Cu(I)-Catalyzed Heterogeneous Multicomponent Polymerizations of Alkynes, Sulfonyl Azides, and NH4Cl
Publisher: American Chemical Society (ACS)
Date: 17-11-2020
An Alkaline Phosphatase-Responsive Aggregation-Induced Emission Photosensitizer for Selective Imaging and Photodynamic Therapy of Cancer Cells
Publisher: American Chemical Society (ACS)
Date: 17-04-2023
Aggregation-induced delayed fluorescence molecules with mechanochromic behaviors for efficient blue organic light-emitting diodes
Publisher: Elsevier BV
Date: 02-2022
Natural Coumarin Isomers with Dramatically Different AIE Properties: Mechanism and Application
Publisher: American Chemical Society (ACS)
Date: 19-04-2023
Treat the “Untreatable” by a Photothermal Agent: Triggering Heat and Immunological Responses for Rabies Virus Inactivation
Publisher: Wiley
Date: 17-11-2022
Abstract: Rabies is a fatal neurological zoonotic disease caused by the rabies virus (RABV), and the approved post‐exposure prophylaxis (PEP) procedure remains unavailable in areas with inadequate medical systems. Although strategies have been proposed for PEP and postinfection treatment (PIT), because of the complexity of the treatment procedures and the limited curative outcome, developing an effective treatment strategy remains a holy grail in rabies research. Herein, a facile approach is proposed involving photothermal therapy (PTT) and photothermally triggered immunological effects to realize effective PEP and PIT simultaneously. The designed photothermal agent (N + TT‐ m CB nanoparticles) featured positively charged functional groups and high photo‐to‐heat efficiency, which are favorable for virus targeting and inactivation. The level of the virus at the site of infection in mice is significantly decreased upon treatment with orthotopic PTT, and the transfer of the virus to the brain is significantly inhibited. Furthermore, the survival ratio of the mice three days postinfection is increased by intracranial injection of N + TT‐ m CB and laser irradiation. Overall, this work provides a platform for the effective treatment of RABV and opens a new avenue for future antiviral studies.
Controllable and Diversiform Topological Morphologies of Self‐Assembling Supra‐Amphiphiles with Aggregation‐Induced Emission Characteristics for Mimicking Light‐Harvesting Antenna
Publisher: Wiley
Date: 23-09-2020
A two-in-one Janus NIR-II AIEgen with balanced absorption and emission for image-guided precision surgery
Publisher: Elsevier BV
Date: 03-2021
In Situ Generation of Red-Emissive AIEgens from Commercial Sources for Nondoped OLEDs
Publisher: American Chemical Society (ACS)
Date: 30-11-2018
Malonitrile‐Functionalized Tetraphenylpyrazine: Aggregation‐Induced Emission, Ratiometric Detection of Hydrogen Sulfide, and Mechanochromism
Publisher: Wiley
Date: 07-12-2017
The Marriage of Aggregation‐Induced Emission with Polymer Science
Publisher: Wiley
Date: 25-09-2019
Abstract: Aggregation-induced emission (AIE) is a novel photophysical phenomenon coined in 2001 by our group and describes the enhanced light emission of some luminogens in the aggregate or solid state. The combination of AIE research and polymer science is a smart approach to produce functional luminescent materials with mechanical strength and excellent processability for real-world applications. In this feature article, recent progress in AIE polymeric systems, including chemical synthesis and physical blending strategies, is summarized. Through chemical synthesis, various AIE-active polymers, such as covalently bonded polymers, supramolecular polymers, and nonconjugated luminescent polymers, can be obtained. Serving as environmentally sensitive probes, AIE luminogens can also be physically doped into polymers to generate interesting systems. Finally, outlooks and perspectives on the future direction of AIE polymeric systems are discussed.
Photoactivatable dihydroalkaloids for cancer cell imaging and chemotherapy with high spatiotemporal resolution
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0MH00931H
Abstract: A photoactivatable strategy is proposed for precise cancer therapy based on photooxidative dehydrogenation reaction, which is demonstrated with the natural dihydroalkaloids of DHCHE and DHSAN as an ex le.
Three-Component Regio- and Stereoselective Polymerizations toward Functional Chalcogen-Rich Polymers with AIE-Activities
Publisher: American Chemical Society (ACS)
Date: 28-08-2019
DOI: 10.1021/JACS.9B06493
Abstract: Polymers containing rich chalcogen elements are rarely reported due to the lack of facile synthesis methods. Herein, a novel multicomponent polymerization route toward chalcogen-rich polymers was introduced. A series of poly(vinyl sulfones) (PVSs) were synthesized at room temperature using readily prepared monomers. PVSs were generated with high regio- and stereo-selectivity in high yields (up to 92.3%). Rich chalcogen elements endowed PVSs with distingctive multifunctionalities. The PVSs possessed good solubility and film-forming ability. Their thin films exhibited outstanding refractive indices up to 1.8062 at 550.0 nm together with good optical transparency in the visible region. Thin films of some polymers can also be fabricated into well-resolved fluorescent photopatterns by photolithography. Thanks to the unique redox properties of selenium, postmodification by oxidation reaction of P
A “simple” donor–acceptor AIEgen with multi-stimuli responsive behavior
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9MH01041F
Abstract: A simple but versatile AIEgen with multi-stimuli responsive functions and multifarious real-life application potentials is reported.
Direct Construction of Acid-Responsive Poly(indolone)s through Multicomponent Tandem Polymerizations
Publisher: American Chemical Society (ACS)
Date: 02-05-2019
DOI: 10.1021/ACSMACROLETT.9B00297
Abstract: Multicomponent polymerizations (MCPs) as a burgeoning field in polymer chemistry has proved to be a powerful and popular tool for the synthesis of functional polymer materials with erse and complex structures. To explore the general applicability of MCPs and enrich the product structures of MCPs, multicomponent tandem polymerizations (MCTPs) with great synthetic simplicity and efficiency were pursued. In this work, MCTPs of
Diversity-Oriented Synthesis of Functional Polymers with Multisubstituted Small Heterocycles by Facile Stereoselective Multicomponent Polymerizations
Publisher: American Chemical Society (ACS)
Date: 27-05-2022
A Cascade Strategy Boosting Hydroxyl Radical Generation with Aggregation-Induced Emission Photosensitizers-Albumin Complex for Photodynamic Therapy
Publisher: American Chemical Society (ACS)
Date: 22-08-2023
Aggregate Science: Much to Explore in the Meso World
Publisher: Elsevier BV
Date: 02-2021
Dietary fatty acids promote lipid droplet diversity through seipin enrichment in an ER subdomain
Publisher: Springer Science and Business Media LLC
Date: 07-2019
DOI: 10.1038/S41467-019-10835-4
Abstract: Exogenous metabolites from microbial and dietary origins have profound effects on host metabolism. Here, we report that a sub-population of lipid droplets (LDs), which are conserved organelles for fat storage, is defined by metabolite-modulated targeting of the C. elegans seipin ortholog, SEIP-1. Loss of SEIP-1 function reduces the size of a subset of LDs while over-expression of SEIP-1 has the opposite effect. Ultrastructural analysis reveals SEIP-1 enrichment in an endoplasmic reticulum (ER) subdomain, which co-purifies with LDs. Analyses of C. elegans and bacterial genetic mutants indicate a requirement of polyunsaturated fatty acids (PUFAs) and microbial cyclopropane fatty acids (CFAs) for SEIP-1 enrichment, as confirmed by dietary supplementation experiments. In mammalian cells, heterologously expressed SEIP-1 engages nascent lipid droplets and promotes their subsequent expansion in a conserved manner. Our results suggest that microbial and polyunsaturated fatty acids serve unexpected roles in regulating cellular fat storage by promoting LD ersity.
Triphenylamine‐Functionalized Multiple‐Resonance TADF Emitters with Accelerated Reverse Intersystem Crossing and Aggregation‐Induced Emission Enhancement for Narrowband OLEDs
Publisher: Wiley
Date: 08-01-2023
Abstract: Multiple‐resonance (MR) thermal activated delayed fluorescence (TADF) emitters have attracted increasing attention in organic electroluminescence devices, owing to their superior quantum efficiency and narrowband emission for high color purity. However, MR‐TADF materials often suffer from severe aggregation‐caused quenching (ACQ) and efficiency roll‐off problems due to their rigid planar structures and the lack of sufficient charge‐transfer (CT) characters with inefficient reverse intersystem crossing (RISC). Herein, by attaching electron‐rich triphenylamine (TPA) with twisted spatial conformation to the MR framework, two efficient narrowband MR‐TADF emitters, namely BNCz‐pTPA and BNCz‐mTPA , are developed. The TPA substituent endows the new emitters with aggregation‐induced emission enhancement (AIEE) for ACQ suppression. The unprecedented AIEE‐MR‐TADF emitters exhibit CT character in high‐lying triplet excited states for faster RISC, while the locally‐excited (LE) character of the first singlet excited state is retained for narrowband emission with high emission efficiency. An organic light‐emitting diode (OLED) based on BNCz‐pTPA exhibits a maximum external quantum efficiency of 27.3% with slow efficiency roll‐off, demonstrating much higher performances than those of the BNCz ‐based OLED. This study may provide a simple but effective approach to constructing high‐performance emitters for wide‐color‐gamut OLED displays.
NIR Clusteroluminescence of Non‐conjugated Phenolic Resins Enabled by Through‐Space Interactions
Publisher: Wiley
Date: 16-06-2023
Abstract: Clusteroluminescence (CL) and through‐space interactions (TSIs) of non‐conjugated molecules have drawn more attention due to their unique photophysical behaviors that are different from largely conjugated luminogens. However, achieving red and even near‐infrared (NIR) emission from such systems is still challenging due to the intrinsic drawbacks of non‐conjugated molecules and the lack of theories for structure–property relationships. In this work, six phenolic resins are designed and synthesized based on two molecule‐engineering strategies: increasing the number of TSIs units and introducing electron‐donating/‐withdrawing groups. All phenolic resins are verified as luminogens with CL property (CLgens), and the first ex le of CLgens with NIR emission (maximum emission wavelength ≥680 nm) and high absolute quantum yield (47 %) is reported. Experiments and theoretical analysis reveal that two TSIs types, through‐space locally excited state and through‐space charge transfer state, play essential roles in achieving CL from these non‐conjugated polymers, which could be manipulated via changing structural conformation and electron density or altering electron transition behaviors. This work not only provides an approach to manipulate TSIs and CL of non‐conjugated polymers but also endows commercially available phenolic resins with high practical value as luminescence materials.
In Situ Generation of Red‐to‐NIR Emissive Radical Cations in the Stomach for Gastrointestinal Imaging
Publisher: Wiley
Date: 04-03-2023
Triphenylpyrazine: methyl substitution to achieve deep blue AIE emitters
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9TC04459K
Abstract: Based on our deep comprehension of the unique excited state decay process of tetraphenylpyrazine derivatives, triphenylpyrazine-3-carbazole ( TrPP-3C ) was designed by replacing the phenyl group with a methyl group at the 3-position of pyrazine.
Multicomponent Polymerizations of Alkynes, Sulfonyl Azides, and 2-Hydroxybenzonitrile/2-Aminobenzonitrile toward Multifunctional Iminocoumarin/Quinoline-Containing Poly(N-sulfonylimine)s
Publisher: American Chemical Society (ACS)
Date: 09-01-2019
DOI: 10.1021/ACSMACROLETT.8B00884
Abstract: Multicomponent polymerizations (MCPs) provide a powerful synthetic tool for the construction of polymers with complex structures and multifunctionalities, owing to their great structural ersity, mild condition, high efficiency, simple procedure, and environmental benefit. They possess significant advantages in synthesizing heteroatom-rich or heterocycle-containing functional polymers through directly constructing fused heterocycles from the MCP. In this work, the MCPs of diynes, disulfonyl azides, and 2-hydroxybenzonitrile or 2-aminobenzonitrile were reported under the catalysis of CuCl and Et
High-Contrast Visualization and Differentiation of Microphase Separation in Polymer Blends by Fluorescent AIE Probes
Publisher: American Chemical Society (ACS)
Date: 24-07-2017
Synthesis of an efficient far-red/near-infrared luminogen with AIE characteristics for in vivo bioimaging applications
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9CC02238D
Abstract: A selenium-containing FR/NIR luminogen with AIE characteristics is reported as an efficient fluorescent probe for in vivo bioimaging applications.
Organic near‐infrared photodetectors with photoconductivity‐enhanced performance
Publisher: Wiley
Date: 28-04-2023
DOI: 10.1002/AGT2.345
Abstract: Organic near‐infrared (NIR) photodetectors with essential applications in medical diagnostics, night vision, remote sensing, and optical communications have attracted intensive research interest. Compared with most conventional inorganic counterparts, organic semiconductors usually have higher absorption coefficients, and their thin active layer could be sufficient to absorb most incident light for effective photogeneration. However, due to the relatively poor charge mobility of organic materials, it remains challenging to inhibit the photogenerated exciton recombination and effectively extract carriers to their respective electrodes. Herein, this challenge was addressed by increasing matrix conductivities of a ternary active layer (D–A–D structure NIR absorber [2TT‐oC6B]:poly(N,N′‐bis‐4‐butylphenyl‐N,N′‐bisphenyl)benzidin [PolyTPD]:[6,6]‐phenyl‐C 61 ‐butyric acid methyl ester [PCBM] = 1:1:1) upon in situ incident light illumination, significantly accelerating charge transport through percolated interpenetrating paths. The greatly enhanced photoconductivity under illumination is intrinsically related to the unique donor–acceptor molecular structures of PolyTPD and 2TT‐oC6B, whereas stable intermolecular interaction has been verified by systematic molecular dynamics simulation. In addition, an ultrafast charge transfer time of 0.56 ps from the NIR aggregation‐induced luminogens of 2TT‐oC6B absorber to PolyTPD and PCBM measured by femtosecond transient absorption spectroscopy is beneficial for effective exciton dissociation. The solution‐processed organic NIR photodetector exhibits a fast response time of 83 μs and a linear dynamic range value of 111 dB under illumination of 830 nm. Therefore, our work has opened up a pioneering window to enhance photoconductivity through in situ photoirradiation and benefit NIR photodetectors as well as other optoelectronic devices.
A multifunctional luminogen with aggregation-induced emission characteristics for selective imaging and photodynamic killing of both cancer cells and Gram-positive bacteria
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TB00572A
Abstract: A positively charged multifunctional AIEgen was developed for selective imaging and photodynamic killing of cancer cells as well as Gram-positive bacteria.
The Role of Structural Hydrophobicity on Cationic Amphiphilic Aggregation-Induced Emission Photosensitizer-Bacterial Interaction and Photodynamic Efficiency
Publisher: American Chemical Society (ACS)
Date: 18-08-2023
Critical Role of High‐Lying Triplet States for Efficient Excitons Utilization in High‐Performance Non‐Doped Deep‐Blue Fluorescent and Hybrid White Organic Light‐Emitting Diodes
Publisher: Wiley
Date: 17-12-2021
Abstract: For organic light‐emitting diodes (OLEDs), the characteristics of high‐lying excited states of pure organic materials significantly affect the utilization of triplet excitons, which are critical in the process of electroluminescence. Herein, two novel molecules, PT‐1 and PT‐2, with deep‐blue emission are obtained, which exhibit nearly identical photophysical behavior in the photoluminescence process. However, the remarkable distinction in the characteristics of the high‐lying triplet excited states between PT‐1 and PT‐2 leads to a significant difference in the electroluminescence performance. Moreover, the non‐doped OLED based on PT‐1 exhibits maximum external quantum efficiency (η ext ) of 6.63% with a low efficiency roll‐off. In addition, the authors employ PT‐1 as the phosphorescent host materials to fabricate two‐color hybrid white OLEDs (WOLEDs), from which they can realize the transformation from warm‐white to quasi‐white light by tuning the thickness of emission layer, with maximum η ext and power efficiency (η p ) of 23.93%/84.37 lm W −1 and 10.49%/33.96 lm W −1 , respectively. These results deeply demonstrate the effects of high‐lying excited states on electroluminescence and facilitate the preparation of functional OLEDs.
Three‐Pronged Attack by Homologous Far‐red/NIR AIEgens to Achieve 1+1+1>3 Synergistic Enhanced Photodynamic Therapy
Publisher: Wiley
Date: 24-03-2020
BioAIEgens Derived from Rosin: How Does Molecular Motion Affect Their Photophysical Processes in Solid State?
Publisher: American Chemical Society (ACS)
Date: 02-2021
DOI: 10.26434/CHEMRXIV.13661588.V1
Abstract: The exploration of artificial luminogens with bright emission has been fully developed with the advancement of synthetic chemistry. However, many of them face problems like weakened emission in the aggregated state as well as poor renewability and sustainability. Therefore, the development of renewable and sustainable luminogens with anti-quenching function in the solid state, as well as to unveil the key factors that influence their luminescence behavior become highly significant. Herein, a new class of natural rosin-derived luminogens with aggregation-induced emission property (AIEgens) have been facilely obtained with good biocompatibility and targeted organelle imaging capability as well as photochromic behavior in the solid state. Mechanistic study indicates that the introduction of the alicyclic moiety helps suppress the excited-state molecular motion to enhance the solid-state emission. The current work fundamentally elucidates the role of alicyclic moiety in luminogen design and practically demonstrates a new source to large-scalely obtain biocompatible AIEgens.
One-Pot Multicomponent Tandem Reactions and Polymerizations for Step-Economic Synthesis of Structure-Controlled Pyrimidine Derivatives and Poly(pyrimidine)s
Publisher: American Chemical Society (ACS)
Date: 26-11-2018
Cationization-Enhanced Type I and Type II ROS Generation for Photodynamic Treatment of Drug-Resistant Bacteria
Publisher: American Chemical Society (ACS)
Date: 18-05-2022
Abstract: Photodynamic therapy as an emerging phototheranostic approach holds great potential for antibacterial treatment, but is limited by compromised reactive oxygen species (ROS) generation in an aggregate and hypoxic microenvironment. Herein, we report a molecular cationization approach to boost the ROS, especially type I ROS generation of aggregation-induced emission (AIE) photosensitizers for photodynamic treatment of drug-resistant bacteria. Such cationization reinforces the electron-accepting ability of the cationic moiety, promotes intersystem crossing (ISC), and increases electron separation and transfer processes. The resultant
In situ monitoring of molecular aggregation using circular dichroism
Publisher: Springer Science and Business Media LLC
Date: 23-11-2018
DOI: 10.1038/S41467-018-07299-3
Abstract: The aggregation of molecules plays an important role in determining their function. Electron microscopy and other methods can only characterize the variation of microstructure, but are not capable of monitoring conformational changes. These techniques are also complicated, expensive and time-consuming. Here, we demonstrate a simple method to monitor in-situ and in real-time the conformational change of ( R )-1,1′-binaphthyl-based polymers during the aggregation process using circular dichroism. Based on results from molecular dynamics simulations and experimental circular dichroism measurements, polymers with “open” binaphthyl rings are found to show stronger aggregation-annihilated circular dichroism effects, with more negative torsion angles between the two naphthalene rings. In contrast, the polymers with “locked” rings show a more restrained aggregation-annihilated circular dichroism effect, with only a slight change of torsion angle. This work provides an approach to monitor molecular aggregation in a simple, accurate, and efficient way.
Alkali-Promoted Tandem Polymerization of Nucleophilic Acetylide Monomers and Aldehydes toward Luminescent Polymeric Materials
Publisher: American Chemical Society (ACS)
Date: 22-06-2022
Ionization and Anion−π+ Interaction: A New Strategy for Structural Design of Aggregation-Induced Emission Luminogens
Publisher: American Chemical Society (ACS)
Date: 08-11-2017
DOI: 10.1021/JACS.7B10150
Abstract: Recent years have witnessed the significant role of anion-π
Evaluation of Structure–Function Relationships of Aggregation-Induced Emission Luminogens for Simultaneous Dual Applications of Specific Discrimination and Efficient Photodynamic Killing of Gram-Posit
Publisher: American Chemical Society (ACS)
Date: 25-09-2019
DOI: 10.1021/JACS.9B07162
Abstract: Bacterial infectious diseases, especially those caused by Gram-positive bacteria, have been seriously threatening human health. Preparation of a multifunctional system bearing both rapid bacterial differentiation and effective antibacterial effects is highly in demand, but remains a severe challenge. Herein, we rationally designed and successfully developed a sequence of aggregation-induced emission luminogens (AIEgens) with orderly enhanced D-A strength. Evaluation of structure-function relationships reveals that AIEgens having intrinsic positive charge and proper ClogP value are able to stain Gram-positive bacteria. Meanwhile, one of the presented AIEgens (TTPy) can generate reactive oxygen species (ROS) in extraordinarily high efficiency under white light irradiation due to the smaller singlet-triplet energy gap. Thanks to the NIR emission, excellent specificity to Gram-positive bacteria, and effective ROS generation efficiency, TTPy has been proved to perform well in selective photodynamic killing of Gram-positive bacteria
Uptake, Distribution, and Bioimaging Applications of Aggregation-Induced Emission Saponin Nanoparticles in Arabidopsis thaliana
Publisher: American Chemical Society (ACS)
Date: 21-08-2017
Abstract: The application of aggregation-induced emission luminogens (AIEgens) has heralded a new age in the analysis of subcellular events and has overcome many of the limitations of conventional fluorescent probes. Despite the extensive literature investigating AIEgens in mammalian cells, few reports exist of their bioimaging applications in plant cells. In this report, we describe the first systematic investigation of the uptake, distribution, and bioimaging applications of AIEgens and AIE saponin nanoparticles in the plant model system Arabidopsis thaliana. We find that the superior photostability, high colocalization with fluorescent proteins, and unique tissue-specific turn-on emission properties make AIEgens well-suited to tackle the emergent challenges faced in plant bioimaging.
A Water‐Soluble AIEgen for Noninvasive Diagnosis of Kidney Fibrosis via SWIR Fluorescence and Photoacoustic Imaging
Publisher: Wiley
Date: 11-2022
Abstract: Early diagnosis of renal fibrosis is crucially significant on account of its worldwide prevalent tendency. Optical imaging in the near‐infrared window has been recognized as an appealing technique for the timely detection of renal dysfunction. However, formulating a contrast agent that allows early monitoring of renal fibrosis and concurrently renally clearable in a normal group is still challenging. Herein, a nanosized fluorophore with aggregation‐induced emission (AIE) features, namely AIE‐4PEG550 NPs, is well‐tailored and amenable to longitudinal visualization of the fibrosis progression specifically in the early‐stage via short‐wave infrared (SWIR, 900–1700 nm) fluorescence and photoacoustic bimodal imaging. The small size (≈26 nm), renally filtrable molecular weight (3.3 kDa), high renal clearance efficiency (93.1 ± 1.7% excretion through the kidneys within 24 h), outstanding imaging performance, and good biocompatibility, together make AIE‐4PEG550 NPs remarkably impressive and far superior to clinical diagnostic assays. The finding in this study would provide a blueprint for the next generation of diagnostic agents for the extent of renal fibrosis.
Facile Construction of Dendritic Amphiphiles with Aggregation-Induced Emission Characteristics for Supramolecular Self-Assembly
Publisher: American Chemical Society (ACS)
Date: 26-05-2022
Synthesis, crystal structure, aggregation-induced emission (AIE) and electroluminescence properties of a novel emitting material based on pyrrolo[3,2-b]pyrrole
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0TC03431B
Abstract: A novel electroluminescent material based on pyrrolo[3,2- b ]pyrrole as skeleton and donor group and dimesitylborons as accept groups has been synthesized and characterized by elemental analysis, mass spectrometry, NMR spectroscopy and X-ray crystallography.
Unusual Through‐Space Interactions between Oxygen Atoms that Mediate Inverse Morphochromism of an AIE Luminogen
Publisher: Wiley
Date: 20-11-2019
Abstract: We have studied the photophysics of tetrafurylethene, an aggregation‐induced emission luminogen with exceptionally short intramolecular O−O distances of 2.80 Å and a significant red‐shifted morphochromism (27 nm) when going from the aggregate to the crystal. The short O−O distances, which are substantially smaller than the sum of the van der Waals radii (3.04 Å), are due to the fact that the oxygen atoms act as an electronic bridge connecting the furan rings on opposite ends of the central double bond, giving rise to a circular delocalization of the π‐electron density across the rings. In the excited state the O−O distance is further reduced to 2.70 Å the increased O−O interaction causes a narrowing of the HOMO–LUMO gap, resulting in the red morphochromism of the emission. Our results show the structural origin of the red‐shifted emission lies in close O−O contacts, paving the way for understanding the clusteroluminescence of oxygen‐rich non‐conjugated systems that emit visible light.
Palladium-catalyzed polyannulation of pyrazoles and diynes toward multifunctional poly(indazole)s under monomer non-stoichiometric conditions
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9PY01057B
Abstract: A novel palladium-catalyzed polymerization route toward polyindazoles with high thermal stability and advanced functionalities in a monomer stoichiometry imbalance-promoted manner.
Bright Aggregation-Induced Emission Nanoparticles for Two-Photon Imaging and Localized Compound Therapy of Cancers
Publisher: American Chemical Society (ACS)
Date: 16-11-2020
Abstract: Photodynamic therapy (PDT), a noninvasive therapeutic strategy for cancer treatment, which always suffers from the low reactive oxygen species (ROS) yield of traditional organic dyes. Herein, we present lipid-encapsulated aggregation-induced emission nanoparticles (AIE NPs) that have a high quantum yield (23%) and a maximum two-photon absorption (TPA) cross-section of 560 GM irradiated by near-infrared light (800 nm). The AIE NPs can serve as imaging agents for spatiotemporal imaging of tumor tissues with a penetration depth up to 505 μm on mice melanoma model. Importantly, the AIE NPs can simultaneously generate singlet oxygen (
Molecular Motion and Nonradiative Decay: Towards Efficient Photothermal and Photoacoustic Systems
Publisher: Wiley
Date: 21-06-2022
Abstract: Nonradiative decay invariably competes with radiative decay during the deexcitation process of matter. In the community of luminescence research, nonradiative decay has been deemed less attractive than radiative decay. However, all things in their being are good for something and so is nonradiative decay. As the molecular motion‐facilitated nonradiative decay (MMFND) effect is inevitable in photophysical processes, it provides a new avenue to convert the harvested light energy into exploitable forms by harnessing molecular motion. In many cases, active molecular motion enables thermal deactivation from excited states. In this Minireview, recent advances in photothermal and photoacoustic systems with MMFND character are summarized. We believe that this presentation of the rational engineering of molecular motion for efficient photothermal generation will deepen the understanding of the relationship between molecular motion and nonradiative decay and navigate people to rethink the positive aspects of nonradiative decay for the establishment of new light‐controllable techniques.
Highly Efficient Deep Blue Aggregation-Induced Emission Organic Molecule: A Promising Multifunctional Electroluminescence Material for Blue/Green/Orange/Red/White OLEDs with Superior Efficiency and Lo
Publisher: American Chemical Society (ACS)
Date: 12-02-2019
Copper-Catalyzed Electrophilic Polyhydroamination of Internal Alkynes
Publisher: American Chemical Society (ACS)
Date: 28-07-2017
Water‐Soluble Organic Nanoparticles with Programable Intermolecular Charge Transfer for NIR‐II Photothermal Anti‐Bacterial Therapy
Publisher: Wiley
Date: 16-04-2021
Abstract: Extensive recent efforts have been put on the design of high‐performance organic near‐infrared (NIR) photothermal agents (PTAs), especially over NIR‐II bio‐window (1000–1350 nm). So far, the development is mainly limited by the rarity of molecules with good NIR‐II response. Here, we report organic nanoparticles of intermolecular charge‐transfer complexes (CTCs) with easily programmable optical absorption. By employing different common donor and acceptor molecules to form CTC nanoparticles (CT NPs), absorption peaks of CT NPs can be controllably tuned from the NIR‐I to NIR‐II region. Notably, CT NPs formed with perylene and TCNQ have a considerably red‐shifted absorption peak at 1040 nm and achieves a good photothermal conversion efficiency of 42 % under 1064 nm excitation. These nanoparticles were used for antibacterial application with effective activity towards both Gram‐negative and Gram‐positive bacteria. This work opens a new avenue into the development of efficient PTAs.
Specific and Quantitative Detection of Albumin in Biological Fluids by Tetrazolate-Functionalized Water-Soluble AIEgens
Publisher: American Chemical Society (ACS)
Date: 25-07-2019
Abstract: The analysis of albumin has clinical significance in diagnostic tests and obvious value to research studies on the albumin-mediated drug delivery and therapeutics. The present immunoassay, instrumental techniques, and colorimetric methods for albumin detection are either expensive, troublesome, or insensitive. Herein, a class of water-soluble tetrazolate-functionalized derivatives with aggregation-induced emission (AIE) characteristics is introduced as novel fluorescent probes for albumin detection. They can be selectively lighted up by site-specific binding with albumin. The resulting albumin fluorescent assay exhibits a low detection limit (0.21 nM), high robustness in aqueous buffer (pH = 6-9), and a broad tunable linear dynamic range (0.02-3000 mg/L) for quantification. The tetrazolate functionality endows the probes with a superior water solubility (>0.01 M) and a high binding affinity to albumin (
Dipole‐Dipole and Anion‐π+ Interaction Manipulation Synergistically Enhance Intrinsic Antibacterial Activities of AIEgens
Publisher: Wiley
Date: 02-09-2022
Abstract: Pathogenic bacteria infections, especially multidrug resistant bacteria infections have aroused worldwide attention due to their severe threats to human beings. Thus, the development of highly effective antibacterial reagents is very important. However, the design of antimicrobials is still quite challenging for the lack of a universal design strategy. Here, a synergistic manipulation strategy of dipole‐dipole and anion‐π + interaction is proposed for constructing highly efficient antimicrobials with aggregation‐induced emission (AIE) feature. Firstly, four anion‐π + ‐type AIE luminogens were designed and synthesized. Due to the electron‐donating and hydrophilic characteristic of methoxy groups, 3MOTPO containing three methoxy groups showed the largest dipole moment (5.06 Debye) and dual anion‐π + interactions in the solid state. Driven by both dipole‐dipole and anion‐π + interactions, 3MOTPO showed the strongest bacterial binding ability and the best antibacterial activities (MIC 90 =3.76 μM). The work offers a deep insight into the rational design of highly efficient antimicrobials for luminescence‐guided antibacterial study.
Molecular Engineering of NIR‐II AIE Luminogen Excited at 1700 nm for Ultradeep Intravital Brain Two‐Photon Fluorescence Imaging
Publisher: Wiley
Date: 08-07-2023
Abstract: The limited tissue penetration depth and spatial resolution are the major bottlenecks for deep‐brain imaging. In this study, molecular engineering by tailoring electron donors is conducted to develop for the first time an NIR‐II (second near‐infrared) emissive fluorescence probe, namely DCTBT, for effective deep‐brain two‐photon fluorescence imaging. Benefiting from its good biocompatibility, high photostability, bright NIR‐II emission as aggregates and large two‐photon fluorescence action cross section at the 1700 nm excitation window, DCTBT offers the imaging depths of 2180 and 1135 µm in mouse brain with removed and intact skull, respectively. These results are the record depths for brain imaging, compared to all kinds of fluorescent probes and all modalities of multiphoton microscopy at all demonstrated excitation wavelengths. Moreover, with DCTBT labeling, hemodynamic imaging of blood flow in mouse brain vessels down to a depth of 714 µm with the intact skull is achieved. Multiphoton fluorescence imaging with the NIR‐II probe DCTBT excited at the 1700 nm window may readily provide methodology for deep‐brain structural and hemodynamic research.
Phospholipid-Mimetic Aggregation-Induced Emission Luminogens for Specific Elimination of Gram-Positive and Gram-Negative Bacteria
Publisher: American Chemical Society (ACS)
Date: 20-02-2023
Aggregation‐enhanced theranostics: AIE sparkles in biomedical field
Publisher: Wiley
Date: 12-2020
DOI: 10.1002/AGT2.7
Abstract: Theranostics referring to the ingenious integration of diagnostics and therapeutics has garnered tremendous attention in these years as it provides a promising opportunity for modern personalized and precision medicine. By virtue of the good biocompatibility, outstanding fluorescence property, easy processability and functionalization, promoted photosensitizing efficiency, as well as facile construction of multi‐modality theranostics, fluorophores with aggregation‐induced emission (AIE) characteristics exhibit inexhaustible and vigorous vitality in the field of theranostics. Numerous significant breakthroughs and state‐of‐the‐art progression have been witnessed in the past few years. This review highlights the tremendous aggregation‐enhanced superiorities of AIE luminogens (AIEgens) in disease theranostics mainly involving diagnostic imaging (fluorescence and room temperature phosphorescence), therapeutic intervention (photodynamic therapy), and feasibility in construction of multi‐modality theranostics based on the experimental measurements and theoretical simulations. Additionally, the latest and advanced developments of AIEgens in disease theranostics in the aspect of corresponding strategies to design highly effective AIE‐active theranostics through triggering aggregation formation are comprehensively summarized. Moreover, a brief conclusion with the discussion of current challenges and future perspectives in this area is further presented.
Visualization of Biogenic Amines and In Vivo Ratiometric Mapping of Intestinal pH by AIE‐Active Polyheterocycles Synthesized by Metal‐Free Multicomponent Polymerizations
Publisher: Wiley
Date: 29-05-2019
Fine Tuning of Emission Behavior, Self-Assembly, Anion Sensing, and Mitochondria Targeting of Pyridinium-Functionalized Tetraphenylethene by Alkyl Chain Engineering
Publisher: American Chemical Society (ACS)
Date: 25-06-2018
Abstract: Compared to the many studies that focus on the development of novel molecular frameworks pertaining to functionalized fluorescent materials, there is lesser emphasis on side chains even though they have a significant impact on the properties and applications of fluorescent materials. In this study, a series of pyridinium-functionalized tetraphenylethene salts (TPEPy-1 to TPEPy-4) possessing different alkyl chains are synthesized, and the influence of chain length on their optical performance and applications is thoroughly investigated. By changing the alkyl chain, the fluorogens exhibit opposite emission behavior in aqueous media because of their distinct hydrophobic nature, and their solid-state emission can be fine-tuned from green to red owing to their distinct molecular configuration. In addition, by increasing the chain length, the microstructure of the self-assembled fluorogens converts from microplates to microrods with various emission colors. Moreover, TPEPy-1 exhibits dual-mode fluorescence "turn-on" response toward NO
AIEgen-Based Bionic Nanozymes for the Interventional Photodynamic Therapy-Based Treatment of Orthotopic Colon Cancer
Publisher: American Chemical Society (ACS)
Date: 11-05-2022
Frontispiece: Phenol‐yne Click Polymerization: An Efficient Technique to Facilely Access Regio‐ and Stereoregular Poly(vinylene ether ketone)s
Publisher: Wiley
Date: 10-08-2017
Efficient Killing of Multidrug‐Resistant Internalized Bacteria by AIEgens In Vivo
Publisher: Wiley
Date: 02-03-2021
Abstract: Bacteria infected cells acting as “Trojan horses” not only protect bacteria from antibiotic therapies and immune clearance, but also increase the dissemination of pathogens from the initial sites of infection. Antibiotics are hard and insufficient to treat such hidden internalized bacteria, especially multidrug‐resistant (MDR) bacteria. Herein, aggregation‐induced emission luminogens (AIEgens) such as N , N ‐diphenyl‐4‐(7‐(pyridin‐4‐yl) benzo [ c ] [1,2,5] thiadiazol‐4‐yl) aniline functionalized with 1‐bromoethane (TBP‐1) and (3‐bromopropyl) trimethylammonium bromide (TBP‐2) (TBPs) show potent broad‐spectrum bactericidal activity against both extracellular and internalized Gram‐positive pathogens. TBPs trigger reactive oxygen species (ROS)‐mediated membrane damage to kill bacteria, regardless of light irradiation. TBPs effectively kill bacteria without the development of resistance. Additionally, such AIEgens activate mitochondria dependent autophagy to eliminate internalized bacteria in host cells. Compared to the routinely used vancomycin in clinic, TBPs demonstrate comparable efficacy against methicillin‐resistant Staphylococcus aureus (MRSA) in vivo. The studies suggest that AIEgens are promising new agents for the treatment of MDR bacteria associated infections.
Visualizing changes of molecular conformation in the solid-state by a common structural determination technique: single crystal X-ray diffraction
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0QM00754D
Abstract: Changes of molecular conformation in the solid state play a vital role in many advanced technologies.
A clickable AIEgen for visualization of macrophage-microbe interaction
Publisher: Elsevier BV
Date: 11-2022
DOI: 10.1016/J.BIOS.2022.114614
Abstract: Visualization of immunocyte-microbe interaction is of great importance to reveal the physiological role and working mechanism of innate and adaptive immune system. The lack of rapid and stable microbial labeling platform and insufficient understanding of macrophage-microbe interaction may delay precautions that could be made. In this contribution, a clickable AIEgen, CDPP-NCS, containing a cationic pyridinium moiety for targeting bacteria and an isothiocyanate moiety for covalently bonding with amine groups, is successfully developed. With the advantages of excellent photostability and rapid bioconjugation with amine groups on the bacterial envelope, the processes of macrophage-bacterium interactions with subcellular resolution has been successfully captured using this clickable AIE probe. Therefore, the new clickable AIEgen is a powerful tool to study the interaction between cell and bacterium.
One-step, rapid fluorescence sensing of fungal viability based on a bioprobe with aggregation-induced emission characteristics
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9QM00732F
Abstract: A smart AIEgen has been developed to rapidly (5 minutes) and precisely differentiate fungal viability in a wash-free manner.
Chiral assembly of organic luminogens with aggregation-induced emission
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1SC02305E
Abstract: This review highlights the recent development of chiral materials with aggregation-induced emission properties, including their molecular structures, self-assembly and functions.
Restriction of Access to the Dark State: A New Mechanistic Model for Heteroatom‐Containing AIE Systems
Publisher: Wiley
Date: 27-08-2019
Structure, Assembly, and Function of (Latent)-Chiral AIEgens
Publisher: American Chemical Society (ACS)
Date: 06-06-2019
Efficient aggregation-induced delayed fluorescent materials based on bipolar carrier transport materials for the fabrication of high-performance nondoped OLEDs with very small efficiency roll-off
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0TC02016H
Abstract: The integration of bipolar carrier transport materials with an aggregation-induced delayed fluorescence unit generates robust luminescent materials, which lead to efficient nondoped OLEDs with high efficiency stability.
Highly efficient photothermal nanoparticles for the rapid eradication of bacterial biofilms
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1NR03471E
Abstract: An effective photothermy generation aggregate system for bacterial biofilm elimination was designed and investigated. Results indicated that the biofilm matrix was destroyed by the nano-system in addition to the killing of the embedded bacteria.
Clustering-Triggered Emission and Persistent Room Temperature Phosphorescence of Sodium Alginate
Publisher: American Chemical Society (ACS)
Date: 20-03-2018
DOI: 10.1021/ACS.BIOMAC.8B00123
Abstract: Nonconventional biomacromolecular luminogens have attracted extensive interest due to their fundamental importance and potential applications in erse areas. To explore novel luminogens and, moreover, to gain deeper insights into their emission mechanism, we study the emission behaviors of sodium alginate (SA), a natural anionic polysaccharide composed of mannuronic (M) and guluronic acids (G). We find that the luminescence from aqueous SA solutions exhibits distinct concentration enhanced emission and aggregation-induced emission (AIE) characteristics. Meanwhile, the ratio of M/G also matters. Rheological measurements reveal the distinct regimes of the solutions, which are consistent with the observed emission, indicative of strong association between the chain entanglement and emission. Moreover, we observe persistent room temperature phosphorescence (RTP) in the amorphous SA solids, which is a rare case even in pure organic aromatic luminogens. Such unique emission can be remarkably enhanced via coordination with Ca
Manipulating Solid-State Intramolecular Motion toward Controlled Fluorescence Patterns
Publisher: American Chemical Society (ACS)
Date: 07-01-2020
Abstract: Molecules have limited mobility in the solid state because of the strong intermolecular interactions, and therefore, applications based on solid-state molecular motions are seldom explored. Herein, by manipulating the solid-state intramolecular motion of tetraphenylethylene (TPE) in a crystallizing polymer matrix, controlled fluorescent patterns with information storage and encoding functionality are developed. The intramolecular mobility of TPE can not only affect the fluorescence intensity but also determine the photocyclization activity, which can be tuned by surrounding polymer rigidity. The soft amorphous region in the semicrystalline polymer facilitates the intramolecular motion to achieve weak blue emission and high photocyclization activity, whereas the rigid crystalline phase restricts the intramolecular motion to give intense blue emission and low photoreactivity. Meanwhile, in the process of crystallization, the dynamic movement of the polymer chain in the crystal growth boundary layer further accelerates the intramolecular motions of TPE, allowing enhanced photoreactivity across crystalline and amorphous regions. The motion-dominated fluorescence allows TPE as a smart molecular robot to generate desired fluorescent patterns triggered by polymer crystallization. Our findings provide a correlation between microscopic molecular motions and macroscopic optical signals.
Time‐Dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE‐Active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation
Publisher: Wiley
Date: 21-10-2019
An easily available ratiometric AIE probe for nitroxyl visualization in vitro and in vivo
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0QM00995D
Abstract: An easily available ratiometric fluorescent probe (TCFPB-HNO) with aggregation-induced emission (AIE) characteristics was developed for the first time for the detection and visualization of nitroxyl (HNO) in vitro and in vivo .
Precise and long-term tracking of mitochondria in neurons using a bioconjugatable and photostable AIE luminogen
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1SC06336G
Abstract: A novel bioconjugatable and photostable AIE luminogen has been rationally synthesized for precise and long-term tracking of neuron mitochondria.
Construction of Covalent Organic Cages with Aggregation‐Induced Emission Characteristics from Metallacages for Mimicking Light‐Harvesting Antenna
Publisher: Wiley
Date: 28-07-2023
Abstract: A series of covalent organic cages built from fluorophores capable of aggregation‐induced emission (AIE) were elegantly prepared through the reduction of preorganized M 2 (L A ) 3 (L B ) 2 ‐type metallacages, simultaneously taking advantage of the synthetic accessibility and well‐defined shapes and sizes of metallacages, the good chemical stability of the covalent cages as well as the bright emission of AIE fluorophores. Moreover, the covalent cages could be further post‐synthetically modified into an amide‐functionalized cage with a higher quantum yield. Furthermore, these presented covalent cages proved to be good energy donors and were used to construct light‐harvesting systems employing Nile Red as an energy acceptor. These light‐harvesting systems displayed efficient energy transfer and relatively high antenna effect, which enabled their use as efficient photocatalysts for a dehalogenation reaction. This research provides a new avenue for the development of luminescent covalent cages for light‐harvesting and photocatalysis.
Isothermal Background-Free Nucleic Acid Quantification by a One-Pot Cas13a Assay Using Droplet Microfluidics
Publisher: American Chemical Society (ACS)
Date: 06-04-2022
DOI: 10.1021/ACS.ANALCHEM.2C00067
Abstract: High sensitivity and specificity nucleic acid detection has been achieved by the Cas13a collateral effect in combination with a separate recombinase polymerase lification (RPA). However, these emerging methods cannot provide accurate quantification of nucleic acids because the two-step assay performance may be compromised if the RPA and Cas13a reactions are simply unified in a single step. In this work, we first addressed the challenges associated with enzymatic incompatibility and the macromolecular crowding effect in the one-pot assay development, making the consolidated RPA-Cas13a assay a facile and robust diagnostic tool. Next, we found that the one-pot reaction cannot precisely quantify the targets at low concentrations. Thus, by leveraging droplet microfluidics, we converted the one-pot assay to a digital quantification format, termed Microfluidics-Enabled Digital Isothermal Cas13a Assay (MEDICA). Due to the droplet compartmentation, MEDICA greatly accelerates the reaction and enables relative detection in 10 min and the end-point quantification in 25 min. Moreover, MEDICA facilitates the droplet binarization for counting because of background-free signals generated by trans-cleavage reporting of Cas13a. Our clinical validation highlights that CRISPR-based isothermal assays are promising for the next generation of nucleic acid quantification methods.
Emission-Tunable Soft Porous Organic Crystal Based on Squaraine for Single-Crystal Analysis of Guest-Induced Gate-Opening Transformation
Publisher: American Chemical Society (ACS)
Date: 04-03-2021
DOI: 10.1021/JACS.0C12153
In-situ electro-responsive through-space coupling enabling foldamers as volatile memory elements
Publisher: Springer Science and Business Media LLC
Date: 06-10-2023
More Is Better: Dual-Acceptor Engineering for Constructing Second Near-Infrared Aggregation-Induced Emission Luminogens to Boost Multimodal Phototheranostics
Publisher: American Chemical Society (ACS)
Date: 09-10-2023
DOI: 10.1021/JACS.3C08627
Activation of Pyroptosis Using AIEgen-Based sp2 Carbon-Linked Covalent Organic Frameworks
Publisher: American Chemical Society (ACS)
Date: 08-08-2023
DOI: 10.1021/JACS.3C04027
From mouse to mouse‐ear cress: Nanomaterials as vehicles in plant biotechnology
Publisher: Wiley
Date: 08-2021
DOI: 10.1002/EXP.20210002
Abstract: Biological applications of nanomaterials as delivery carriers have been embedded in traditional biomedical research for decades. Despite lagging behind, recent significant breakthroughs in the use of nanocarriers as tools for plant biotechnology have created great interest. In this Perspective, we review the outstanding recent works in nanocarrier‐mediated plant transformation and its agricultural applications. We analyze the chemical and physical properties of nanocarriers determining their uptake efficiency and transport throughout the plant body.
Principles of Aggregation‐Induced Emission: Design of Deactivation Pathways for Advanced AIEgens and Applications
Publisher: Wiley
Date: 18-05-2020
Design and performance study of high efficiency/low efficiency roll-off/high CRI hybrid WOLEDs based on aggregation-induced emission materials as fluorescent emitters
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9QM00539K
Abstract: AIEgens TPB-AC and CP-BP-PXZ are used as non-doped blue and green layers, and Ir(dmppr-mp) 2 ( m) doped TCTA is used as red layer to construct high-performance hybrid WOLEDs.
A Discrete Platinum(II) Metallacycle Harvesting Triplet Excitons for Solution‐Processed Deep‐Red Organic Light‐Emitting Diodes
Publisher: Wiley
Date: 18-12-2022
Abstract: Platinum(II) coordination‐driven architectures have exhibited unique features in fabricating functional supramolecular materials. By introducing luminescent moieties into the ligand structure, various light‐emitting metallacycles and metallacages have been facilely prepared, presenting specific applications in chemical sensing, light‐harvesting, and bio‐imaging. Except for building up the metal–ligand bonds, the platinum(II) center should also benefit the ultimate luminescence due to its unique photophysical traits. Here, a platinum(II) metallacycle with deep‐red emission for solution‐processed organic light‐emitting diodes is reported. This metallacycle is assembled by mixing a 180° di‐Pt(II) acceptor with a pyridyl‐decorated ligand functionalized by a deep‐red fluorescent emitter. Notably, the platinum(II) acceptor permits the efficient intramolecular transfer of all electrically generated singlet and triplet excitons from itself to the fluorescent moiety, which dramatically enhances the external quantum efficiency of the device compared with the one consisting of the sole ligand. The present results reveal the function of platinum(II) metallacycles in light‐emitting devices, a finding which should apply to other coordination‐driven architectures with versatile properties.
Evoking Photothermy by Capturing Intramolecular Bond Stretching Vibration-Induced Dark-State Energy
Publisher: American Chemical Society (ACS)
Date: 11-03-2020
The coupling and competition of crystallization and phase separation, correlating thermodynamics and kinetics in OPV morphology and performances
Publisher: Springer Science and Business Media LLC
Date: 12-01-2021
DOI: 10.1038/S41467-020-20515-3
Abstract: The active layer morphology transition of organic photovoltaics under non-equilibrium conditions are of vital importance in determining the device power conversion efficiency and stability however, a general and unified picture on this issue has not been well addressed. Using combined in situ and ex situ morphology characterizations, morphological parameters relating to kinetics and thermodynamics of morphology evolution are extracted and studied in model systems under thermal annealing. The coupling and competition of crystallization and demixing are found to be critical in morphology evolution, phase purification and interfacial orientation. A unified model summarizing different phase diagrams and all possible kinetic routes is proposed. The current observations address the fundamental issues underlying the formation of the complex multi-length scale morphology in bulk heterojunction blends and provide useful morphology optimization guidelines for processing devices with higher efficiency and stability.
Catalyst-free synthesis of diverse fluorescent polyoxadiazoles for the facile formation and morphology visualization of microporous films and cell imaging
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D2SC05960F
Abstract: A catalyst-free multicomponent polymerization method was developed toward fluorescent polyoxadiazoles with ersified topological structures and applications in the facile formation and morphology visualization of microporous films and cell imaging.
NIR Clusteroluminescence of Non‐conjugated Phenolic Resins Enabled by Through‐Space Interactions
Publisher: Wiley
Date: 16-06-2023
Abstract: Clusteroluminescence (CL) and through‐space interactions (TSIs) of non‐conjugated molecules have drawn more attention due to their unique photophysical behaviors that are different from largely conjugated luminogens. However, achieving red and even near‐infrared (NIR) emission from such systems is still challenging due to the intrinsic drawbacks of non‐conjugated molecules and the lack of theories for structure–property relationships. In this work, six phenolic resins are designed and synthesized based on two molecule‐engineering strategies: increasing the number of TSIs units and introducing electron‐donating/‐withdrawing groups. All phenolic resins are verified as luminogens with CL property (CLgens), and the first ex le of CLgens with NIR emission (maximum emission wavelength ≥680 nm) and high absolute quantum yield (47 %) is reported. Experiments and theoretical analysis reveal that two TSIs types, through‐space locally excited state and through‐space charge transfer state, play essential roles in achieving CL from these non‐conjugated polymers, which could be manipulated via changing structural conformation and electron density or altering electron transition behaviors. This work not only provides an approach to manipulate TSIs and CL of non‐conjugated polymers but also endows commercially available phenolic resins with high practical value as luminescence materials.
Aggregation-Induced Delayed Fluorescence Luminogens with Accelerated Reverse Intersystem Crossing for High-Performance OLEDs
Publisher: American Chemical Society (ACS)
Date: 25-10-2019
Near-Infrared-II In Vivo Visualization and Quantitative Tracking of Micro/Nanoplastics in Fish
Publisher: American Chemical Society (ACS)
Date: 02-10-2023
A Facile Structural Isomerization‐Induced 3D Spatial D‐A Interlocked Network for Achieving NIR‐II Phototheranostic Agents
Publisher: Wiley
Date: 15-11-2022
Abstract: The performances of second near‐infrared (NIR‐II) organic phototheranostic agents (OPTAs) depend on both molecular structure and molecular packing when used as nanoparticles (NPs). Herein, we proposed a facile structural isomerization‐induced 3D spatial donor (D)‐acceptor (A) interlocked network for achieving NIR‐II OPTAs. Two isomers, 4MNVDPP and 6MNVDPP were synthesized and formulated into NPs. 6MNVDPP, which has a larger electrostatic potential difference, exhibits a compact 3D spatial D‐A interlocked network in the crystal form, while 4MNVDPP forms 2D D‐D type J ‐aggregates. Thus, 6MNVDPP NPs show red‐shifted NIR absorption and larger molar extinction coefficient than 4MNVDPP NPs. Thanks to the typical NIR‐II emission, superior photothermal‐stability, high photothermal conversion efficiency (89 %) and reactive oxygen species production capacity, 6MNVDPP NPs exhibit outstanding NIR‐II tiny capillary vasculature/tumor imaging ability and synergistic photothermal hotodynamic anti‐cancer effect in vivo.
A Water‐Stable and Red‐Emissive Radical Cation for Mutp53 Cancer Therapy
Publisher: Wiley
Date: 17-10-2022
Abstract: Compared with conventional closed‐shell fluorophores, radical cations provide an opportunity for development of red‐to‐NIR fluorophores with small sizes and easy preparation. However, most radical cations reported in the literature suffer from poor stability in water solution and are almost non‐emissive. To tackle this challenge, we herein develop a deep‐red‐emissive and water‐stable pyrrole radical cation P⋅ + −DPA−Zn, which can be easily generated from P−DPA−Zn by air oxidation. The deep‐red‐emissive P⋅ + −DPA−Zn can be used for imaging‐guided mitochondria‐targeted delivery of Zn 2+ into cancer cells to promote mutant p53 proteins degradation and abrogate mutp53‐manifested gain of function, including reduced chemotherapy resistance, inhibited cancer cell migration, decreased tumor cell colony and sphere formation. The water‐stable and deep‐red emissive pyrrole radical cation is thus promising for cancer theranostic applications.
1 + 1 >> 2: Dramatically Enhancing the Emission Efficiency of TPE‐Based AIEgens but Keeping their Emission Color through Tailored Alkyl Linkages
Publisher: Wiley
Date: 21-02-2018
Keto-salicylaldehyde azine: a kind of novel building block for AIEgens and its application in tracking lipid droplets
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0QM00405G
Abstract: KSA-based fluorescent probes exhibit higher flexibility in tuning emission color and selectivity in LDs, which could be applied as a reporter for monitoring LDs changes in dynamic process and larva zebrafish development.
High-Performance Doping-Free Hybrid White OLEDs Based on Blue Aggregation-Induced Emission Luminogens
Publisher: American Chemical Society (ACS)
Date: 22-09-2017
Abstract: Doping-free white organic light-emitting diodes (DF-WOLEDs) have aroused research interest because of their simple properties. However, to achieve doping-free hybrid WOLEDs (DFH-WOLEDs), avoiding aggregation-caused quenching is challenging. Herein, blue luminogens with aggregation-induced emission (AIE) characteristics, for the first time, have been demonstrated to develop DFH-WOLEDs. Unlike previous DFH-WOLEDs, both thin ( 10 nm) AIE luminogen (AIEgen) can be used for devices, enhancing the flexibility. Two-color devices show (i) pure-white emission, (ii) high CRI (85), and (iii) high efficiency. Particularly, 19.0 lm W
Photo-Enhanced Chemotherapy Performance in Bladder Cancer Treatment via Albumin Coated AIE Aggregates
Publisher: American Chemical Society (ACS)
Date: 12-04-2022
Abstract: The implementation of cisplatin-based neoadjuvant chemotherapy (NAC) plays a key role in conjunction with surgical resection in preventing bladder cancer progression and recurrence. However, the significant dose-dependent toxic side effects of NAC are still a major challenge. To solve this problem, we developed a photoenhanced cancer chemotherapy (PECC) strategy based on AIEgen ((E)-3-(2-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)vinyl)-1,1-dimethyl-1
Porphyrin-Based Two-Dimensional Layered Metal–Organic Framework with Sono-/Photocatalytic Activity for Water Decontamination
Publisher: American Chemical Society (ACS)
Date: 27-12-2022
Abstract: Water treatment is crucial to improve the water quality and reduce diarrheal and chronological diseases caused by excessive discharge of organic dyes and other waste. The development and expansion of efficient catalysts for the degradation and sterilization of organic dyes has attracted widespread attention. Herein, we report an ex le of a porphyrin-based two-dimensional layered metal-organic framework (MOF) (2DZnTcpp) and its efficient sono- hotocatalytic degradation of organic dyes and bactericidal activity. The dislocated layers effectively avoid close π-π stacking and provide a porous space for oxygen/water/dye contact. The introduction of Zn ions increases the spin orbital coupling through the heavy atom effect and promotes the intersystem crossing process for singlet oxygen generation. The effective ligand-to-metal charge transfer and the excessive open Zn catalytic sites also facilitate water splitting for hydroxyl radical generation. These features together promote the reactive oxygen species (ROS) generation of 2DZnTcpp under light illumination or ultrasound sonication. It is worth noting that the 2DZnTcpp with a high specific surface area and porosity shows efficient sono- hotocatalytic degradation of organic dye waste. Moreover, 2DZnTcpp could also largely inactivate Escherichia coli under light irradiation (the light power of 1 sun) or ultrasound sonication for 30 min with efficiencies over 99.99999%. This work provides an approach for the design and synthesis of MOF-based sono- hotocatalysts used in the purification and treatment of textile wastewater and is committed to the establishment of a more efficient, fast, and environmentally friendly catalytic system.
Development of Reaction-Based AIE Handy Pen for Visual Detection of Toxic Vapors
Publisher: American Chemical Society (ACS)
Date: 19-01-2021
In vitro anticancer activity of AIEgens
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9BM00881K
Abstract: AIEgens possess superior cytotoxicity, tumor invasion, and hemolysis against cancer cells and cancer stem cells. Simple structural modifications enable them as highly biocompatible, image-guided chemotherapy agents.
Multifaceted Cargo Recruitment and Release from Artificial Membraneless Organelles
Publisher: Wiley
Date: 21-05-2022
Abstract: Liquid‐liquid phase separation (LLPS) drives membraneless organelles (MLOs) formation for organizing biomolecules. Artificial MLOs (AMLOs) have been constructed mostly via the LLPS of engineered proteins capable of regulating limited types of biomolecules. Here, leveraging a minimalist AMLO, driven by LLPS of polymer‐oligopeptide hybrids, enrichment, recruitment, and release of multifaceted cargoes are quantitatively shown, including small fluorescent molecules, fluorophore‐containing macromolecules, proteins, DNAs, and RNAs. Cargoes show up to 10 5 ‐fold enrichment, whilst recruitment and release are triggered by variations of temperature, pH, and/or ionic strength. Also, the first efficacious, rapid, and reversible control of aggregation‐induced emission with over 30 folds of modulation of overall fluorescence intensity is achieved, by intensifying the aggregation of luminogens in AMLO. The AMLO is a simple yet versatile platform for potential drug delivery and biosensor applications.
Polarized resonance synchronous spectroscopy as a powerful tool for studying the kinetics and optical properties of aggregation-induced emission
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9TC04106K
Abstract: Light scattering and absorption both contribute to the UV-vis extinction quantified with a UV-vis spectrophotometer, but they differ drastically in their causes and effects.
Self-Assembled Metallacage with Second Near-Infrared Aggregation-Induced Emission for Enhanced Multimodal Theranostics
Publisher: American Chemical Society (ACS)
Date: 05-07-2202
DOI: 10.1021/JACS.2C03895
Abstract: The construction of supramolecular coordination complexes (SCCs) featuring prominent cancer theranostic functions is an appealing yet significantly challenging task. In this study, we rationally designed and facilely constructed a prism-like metallacage C-DTTP with efficient fluorescence emission in the second near-infrared (NIR-II) region through the assembly of an aggregation-induced emission-active four-arm ligand with 90° Pt acceptors Pt(PEt
A Biomimetic Aggregation‐Induced Emission Photosensitizer with Antigen‐Presenting and Hitchhiking Function for Lipid Droplet Targeted Photodynamic Immunotherapy
Publisher: Wiley
Date: 11-07-2021
Abstract: Photodynamic therapy (PDT) is a promising alternative approach for effective cancer treatment that is associated with an antitumor immune response. However, immunosuppression of the tumor microenvironment limits the immune response induced by PDT. Stimulation and proliferation of T cells is a critical step for generating immune responses and depends on the efficient presentation of tumor antigens and co‐stimulatory molecules by antigen‐presenting cells (APCs). Here, biomimetic aggregation‐induced emission (AIE) photosensitizers with antigen‐presenting and hitchhiking abilities (DC@AIEdots) are developed by coating dendritic cell (DC) membranes on the nanoaggregates of the AIEgens. Notably, the inner AIE molecules can selectively accumulate in lipid droplets of tumor cells, and the outer cell membrane can facilitate the hitchhiking of DC@AIEdots onto the endogenous T cells and enhance the tumor delivery efficiency by about 1.6 times. Furthermore, DC@AIEdots can stimulate the in vivo proliferation and activation of T cells and trigger the immune system. The potential applications of therapeutic agents targeting lipid droplets for immunotherapy are indicated and a new hitchhiking approach for drug delivery is provided. Lastly, the study presents a photoactive and artificial antigen‐presenting platform for effective T cell stimulation and cancer photodynamic immunotherapy.
AIE‐Based Theranostic Probe for Sequential Imaging and Killing of Bacteria and Cancer Cells
Publisher: Wiley
Date: 17-04-2020
Transition metal-free thiol–yne click polymerization toward Z-stereoregular poly(vinylene sulfide)s
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9PY00161A
Abstract: An efficient K 3 PO 4 -mediated thiol–yne click polymerization was established, and regio- and stereoregular poly(vinylene sulfide)s with Z -isomers were produced.
Oxygen as a Crucial Comonomer in Alkyne-Based Polymerization toward Functional Poly(tetrasubstituted furan)s
Publisher: American Chemical Society (ACS)
Date: 31-08-2018
Programmed Self-Assembly of Protein-Coated AIE-Featured Nanoparticles with Dual Imaging and Targeted Therapy to Cancer Cells
Publisher: American Chemical Society (ACS)
Date: 18-06-2020
Specific Two-Photon Imaging of Live Cellular and Deep-Tissue Lipid Droplets by Lipophilic AIEgens at Ultralow Concentration
Publisher: American Chemical Society (ACS)
Date: 02-07-2018
Direct Visualization and Quantification of Maternal Transfer of Silver Nanoparticles in Zooplankton
Publisher: American Chemical Society (ACS)
Date: 31-07-2020
Nonenzyme Cascaded Amplification Biosensor Based on Effective Aggregation Luminescence Caused by Disintegration of Silver Nanoparticles
Publisher: American Chemical Society (ACS)
Date: 24-06-2020
Highly emissive phenylene-expanded [5]radialene
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0CC00122H
Abstract: Star: a pentagonal conjugated radialene macrocycle was one-pot synthesized for the first time. The fantastic pentagonal architecture is revealed by its single crystal structure, and affords the smallest ring strain and the best conjugation.
Novel strategy to prepare fluorescent polymeric nanoparticles based on aggregation-induced emission via precipitation polymerization for fluorescent lateral flow assay
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0QM00998A
Abstract: A novel strategy to prepare fluorescent polymeric nanoparticles based on aggregation-induced emission via precipitation polymerization for fluorescent lateral flow assay.
Add the Finishing Touch: Molecular Engineering of Conjugated Small Molecule for High‐Performance AIE Luminogen in Multimodal Phototheranostics
Publisher: Wiley
Date: 03-08-2021
Abstract: Phototheranostics based on luminogens with aggregation‐induced emission (AIE) characteristics is captivating increasing research interest nowadays. However, AIE luminogens are inherently featured by inferior absorption coefficients (ε) resulting from the distorted molecular geometry. Besides, molecular innovation of long‐wavelength light‐excitable AIE luminogens with highly efficient phototheranostic outputs is an appealing yet significantly challenging task. Herein, on the basis of a fused‐ring electron acceptor–donator–acceptor (A–D–A) type molecule (IDT) with aggregation‐caused quenching (ACQ) properties, molecular engineering smoothly proceeds and successfully yields a novel AIE luminogen (IDT‐TPE) via simply modifying tetraphenylethene (TPE) moieties on the sides of IDT backbone. The AIE tendency endows IDT‐TPE nanoparticles with enhanced fluorescence brightness and far superior fluorescence imaging performance to IDT nanoparticles for mice tumors. Moreover, IDT‐TPE nanoparticles exhibit near‐infrared light‐excitable features with a high ε of 8.9 × 10 4 m −1 cm −1 , which is roughly an order of magnitude higher than that of most previously reported AIE luminogens. Combining with their reactive oxygen species generation capability and extremely high photothermal conversion efficiency (59.7%), IDT‐TPE nanoparticles actualize unprecedented performance in multimodal phototheranostics. This study thus brings useful insights into the development of versatile phototheranostic materials with great potential for practical cancer theranostics.
Self‐reporting fluorescence deciphers the antibacterial nature of cationic amphiphiles: Monomer or aggregate?
Publisher: Wiley
Date: 06-06-2023
DOI: 10.1002/AGT2.366
Abstract: Cationic hiphile aggregates exhibit superior antibacterial activity than monomers. However, the antimicrobial mechanism of aggregates has not been well understood because it is difficult to distinguish and monitor aggregate and monomer in antimicrobial process. Herein, three bola‐type cationic hiphiles with aggregation‐induced emission property have been developed to show distinguishable fluorescence in their monomer and aggregate. The hydrophilicity of monomer and the stability of aggregate are finely tuned by tailoring the linkers between two quaternary ammonium end groups and tetraphenylethylene skeleton. The sensitive fluorescence switching of monomer and aggregate achieves the quantitative monitoring of dynamic interaction of three hiphiles with bacteria. The aggregates with cationic charges first attach to bacterial surface, and the monomers subsequently dissociate from aggregates to penetrate bacterial membrane. Further, our results reveal the vital role of stability of aggregates during antimicrobial process, shedding light on the rational design of high‐efficient antimicrobials.
Synergistically Boosting the Circularly Polarized Luminescence of Functionalized Pillar[5]arenes by Polymerization and Aggregation
Publisher: Wiley
Date: 22-10-2023
Heteroaromatic Hyperbranched Polyelectrolytes: Multicomponent Polyannulation and Photodynamic Biopatterning
Publisher: Wiley
Date: 17-06-2021
Abstract: We reported an efficient multicomponent polyannulation for in situ generation of heteroaromatic hyperbranched polyelectrolytes by using readily accessible internal diynes and low‐cost, commercially available arylnitriles, NaSbF 6 , and H 2 O/AcOH. The polymers were obtained in excellent yields (up to 99 %) with extraordinary high molecular weights (M w up to 1.011×10 6 ) and low polydispersity indices. The resulting polymers showed good processibility and high quantum yields with tunable emission in the solid state, making them ideal materials for highly ordered fluorescent photopatterning. These hyperbranched polyelectrolytes also possessed strong ability to generate reactive oxygen species, which allowed their applications in efficient bacterial killing and customizable photodynamic patterning of living organisms in a simple and cost‐effective way.
Sulfur-bridged tetraphenylethylene AIEgens for deep-blue organic light-emitting diodes
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TC01509K
Abstract: Pure color deep-blue organic light-emitting diodes based on sulfur-bridged tetraphenylethylene AIEgens show efficient device performances.
Lithium Ion Nanocarriers Self-Assembled from Amphiphiles with Aggregation-Induced Emission Activity
Publisher: American Chemical Society (ACS)
Date: 08-12-2017
Sparks fly when AIE meets with polymers
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9QM00404A
Abstract: The special structure of AIEgens facilitates the understanding and application of polymers.
Simultaneously boosting the conjugation, brightness and solubility of organic fluorophores by using AIEgens
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0SC03423A
Abstract: AIEgens are exploited to simultaneously extend the conjugation, boost the brightness, and increase the solubility of organic near-infrared fluorophores, representing a new strategy for developing high-performance emitters for biomedical imaging.
Dual detection of bioaccumulated Hg2+ based on luminescent bacteria and aggregation-induced emission
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9CC02782C
Abstract: We develop a dual detection strategy for bioaccumulated Hg 2+ based on turn-off of the bioluminescence of P. phosphoreum bacteria by disrupting the quorum sensing system and turn-on of the photoluminescence of an aggregation-induced emission (AIE) probe by forming aggregates with Hg 2+ inside the bacteria.
“Seeing” and Controlling Photoisomerization by (Z)-/(E)-Isomers with Aggregation-Induced Emission Characteristics
Publisher: American Chemical Society (ACS)
Date: 30-09-2019
Abstract: Efficient photoisomerization of chromophores is important in living systems, and structural constraints of protein pocket on chromophores are the probable reason for moving their dynamic reaction equilibrium forward. On the other hand, photochemical reaction to switch a molecule from one isomer to the other with different geometry and property in a high yield will continue to play a vital role in the synthetic chemistry and material science. Because of the important role of efficient photoisomerization, a biomimetic approach for "seeing" and controlling the photoisomerization is developed by using the technology of aggregation-induced emission (AIE) with supramolecular chemistry. It is revealed that a (
Enantioselective recognition based on aggregation-induced emission
Publisher: Elsevier BV
Date: 06-2023
Centimeter-Deep NIR-II Fluorescence Imaging with Nontoxic AIE Probes in Nonhuman Primates
Publisher: American Association for the Advancement of Science (AAAS)
Date: 2020
Abstract: Fluorescence probes with aggregation-induced emission (AIE) characteristics are of great importance in biomedical imaging with superior spatial and temporal resolution. However, the lack of toxicity studies and deep tissue imaging in nonhuman primates hinders their clinical translation. Here, we report the blood chemistry and histological analysis in nonhuman primates treated with AIE probes over tenfold of an intravenous dose of clinically used indocyanine green (ICG) during a study period of 36 days to demonstrate AIE probes are nontoxic. Furthermore, through bright and nontoxic AIE probes and fluorescence imaging in the second window (NIR-II, 1,000–1,700 nm), we achieve an unprecedented 1.5-centimeter-deep vascular imaging in nonhuman primates, breaking the current limitation of millimeter-deep NIR-II fluorescence imaging. Our important findings, i.e., nontoxic features of AIE probes and centimeter-deep NIR-II vascular imaging in nonhuman primates, may facilitate successful translation of AIE probes in clinical trials.
Organic Long-Persistent Luminescence from a Single-Component Aggregate
Publisher: American Chemical Society (ACS)
Date: 20-01-2022
DOI: 10.1021/JACS.1C11480
Abstract: Long-persistent luminescence (LPL), also known as afterglow, is a phenomenon in which the material shows long-lasting luminescence after the cessation of the excitation source. The research of LPL continues to attract much interest due to its fundamental nature and its potential in the development of the next generation of functional materials. However, most of the current LPL materials are multicomponent inorganic systems obtained after harsh synthetic procedures and often use rare-earth metals. Recently, metal free organic long-persistent luminescence (OLPL) has gained much interest because it can bypass many of the disadvantages of inorganic systems. To date, the most successful method to generate OLPL systems is to access charge-separated states through binary donor-acceptor exciplex systems. However, it has been reported that the ratios of the binary systems affect OLPL properties, complicating the reproducibility and large-scale production of OLPL materials. Simpler OLPL systems can overcome these issues for the benefit of the development and adoption of OLPL systems. Here, we report on the rational design and synthesis of a single-component OLPL system with detectable afterglow for at least 12 min under ambient conditions. This work exemplifies an easy design principle for new OLPL materials. The investigation of the material provides valuable insights toward the generation of OLPL from a single-component system.
NIR‐II AIEgens: A Win–Win Integration towards Bioapplications
Publisher: Wiley
Date: 15-12-2020
Achieving Multiple Quantum-Interfered States via Through-Space and Through-Bond Synergistic Effect in Foldamer-Based Single-Molecule Junctions
Publisher: American Chemical Society (ACS)
Date: 28-04-2022
DOI: 10.1021/JACS.2C00322
Abstract: The construction of multivalued logic circuits by multiple quantum-interfered states at the molecular level can make full use of molecular ersity and versatility, broadening the application of molecular electronics. Understanding charge transport through different conducting pathways and how they interact with each other in molecules with a secondary structure is an indispensable foundation to achieve this goal. Herein, we elucidate the synergistic effect from through-space and through-bond conducting pathways in foldamers derived from
Highly sensitive switching of solid-state luminescence by controlling intersystem crossing
Publisher: Springer Science and Business Media LLC
Date: 02-08-2018
DOI: 10.1038/S41467-018-05476-Y
Abstract: The development of intelligent materials, in particular those showing the highly sensitive mechanoresponsive luminescence (MRL), is desirable but challenging. Here we report a design strategy for constructing high performance On–Off MRL materials by introducing nitrophenyl groups to molecules with aggregation-induced emission (AIE) characteristic. The on–off methodology employed is based on the control of the intersystem crossing (ISC) process. Experimental and theoretical investigations reveal that the nitrophenyl group effectively opens the nonradiative ISC channel to impart the high sensitivity and contrast On–Off behavior. On the other hand, the twisted AIE luminogen core endows enhanced reversibility and reduces the pressure required for the luminescence switching. Thin films can be readily fabricated from the designed materials to allow versatile applications in optical information recording and haptic sensing. The proposed design strategy thus provides a big step to expand the scope of the unique On–Off MRL family.
Targeted Theranostics for Tuberculosis: A Rifampicin-Loaded Aggregation-Induced Emission Carrier for Granulomas Tracking and Anti-Infection
Publisher: American Chemical Society (ACS)
Date: 13-05-2020
Reverse Thinking of the Aggregation‐Induced Emission Principle: Amplifying Molecular Motions to Boost Photothermal Efficiency of Nanofibers**
Publisher: Wiley
Date: 15-09-2020
A photo-triggered self-accelerated nanoplatform for multifunctional image-guided combination cancer immunotherapy
Publisher: Springer Science and Business Media LLC
Date: 25-08-2023
DOI: 10.1038/S41467-023-40996-2
Abstract: Precise and efficient image-guided immunotherapy holds great promise for cancer treatment. Here, we report a self-accelerated nanoplatform combining an aggregation-induced emission luminogen (AIEgen) and a hypoxia-responsive prodrug for multifunctional image-guided combination immunotherapy. The near-infrared AIEgen with methoxy substitution simultaneously possesses boosted fluorescence and photoacoustic (PA) brightness for the strong light absorption ability, as well as lified type I and type II photodynamic therapy (PDT) properties via enhanced intersystem crossing process. By formulating the high-performance AIEgen with a hypoxia-responsive paclitaxel (PTX) prodrug into nanoparticles, and further camouflaging with macrophage cell membrane, a tumor-targeting theranostic agent is built. The integration of fluorescence and PA imaging helps to delineate tumor site sensitively, providing accurate guidance for tumor treatment. The light-induced PDT effect could consume the local oxygen and lead to severer hypoxia, accelerating the release of PTX drug. As a result, the combination of PDT and PTX chemotherapy induces immunogenic cancer cell death, which could not only elicit strong antitumor immunity to suppress the primary tumor, but also inhibit the growth of distant tumor in 4T1 tumor-bearing female mice. Here, we report a strategy to develop theranostic agents via rational molecular design for boosting antitumor immunotherapy.
Tunable Linear and Nonlinear Optical Properties from Room Temperature Phosphorescent Cyclic Triimidazole‐Pyrene Bio‐Probe
Publisher: Wiley
Date: 29-10-2021
Abstract: Organic materials with multiple emissions tunable by external stimuli represent a great challenge. TTPyr, crystallizing in different polymorphs, shows a very rich photophyisics comprising excitation‐dependent fluorescence and phosphorescence at ambient conditions, and mechanochromic and thermochromic behavior. Transformation among the different species has been followed by thermal and X‐ray diffraction analyses and the emissive features interpreted through structural results and DFT/TDDFT calculations. Particularly intriguing is the polymorph TTPyr(HT), serendipitously obtained at high temperature but stable also at room temperature, whose non‐centrosymmetric structure guarantees an SHG efficiency 10 times higher than that of standard urea. Its crystal packing, where only the TT units are strongly rigidified by π‐π stacking interactions while the Pyr moieties possess partial conformational freedom, is responsible for the observed dual fluorescence. The potentialities of TTPyr for bioimaging have been successfully established.
Bioinspired Simultaneous Changes in Fluorescence Color, Brightness, and Shape of Hydrogels Enabled by AIEgens
Publisher: Wiley
Date: 05-02-2020
Photoresponsive Polymers with Aggregation-Induced Emission
Publisher: American Chemical Society (ACS)
Date: 29-04-2021
Multicomponent Polymerizations Involving Green Monomers
Publisher: Wiley
Date: 13-12-2020
Emerging Applications of Aggregation‐Induced Emission Luminogens in Bacterial Biofilm Imaging and Antibiofilm Theranostics
Publisher: Wiley
Date: 13-01-2023
Abstract: Threats posed by recalcitrant bacterial biofilms have been continuously challenging the public health due to the dramatically magnified antibiotic resistance resulted from the complicated biofilm microenvironment. Urgent demands on effective biofilm combating have propelled the rapid exploration of high‐performance antibiofilm systems. Thanks to the distinguished features of aggregation‐intensified fluorescence and aggregation‐enhanced generation of reactive oxygen species, aggregation‐induced emission luminogens (AIEgens) are becoming increasingly eye‐catching in the field of biofilm combating by serving as excellent fluorescence imaging probes or theranostic agents. This review aims to, for the first time, outline the current progress of AIEgens in bacterial biofilm imaging and antibiofilm theranostics. The up‐to‐date advancements of AIEgens in enzyme‐responsive biofilm imaging, discriminative imaging of Gram‐positive bacterial biofilm, as well as biofilm viability monitoring are summarized at first. Subsequently, the antiadhesion intervention‐mediated prevention of biofilm formation and photodynamic therapy‐involved eradication of preexisting biofilms are detailedly elucidated. Finally, a brief conclusion as well as a discussion on the current challenges and future expectations is presented.
A thiol probe for measuring unfolded protein load and proteostasis in cells
Publisher: Springer Science and Business Media LLC
Date: 07-09-2017
DOI: 10.1038/S41467-017-00203-5
Abstract: When proteostasis becomes unbalanced, unfolded proteins can accumulate and aggregate. Here we report that the dye, tetraphenylethene maleimide (TPE-MI) can be used to measure cellular unfolded protein load. TPE-MI fluorescence is activated upon labelling free cysteine thiols, normally buried in the core of globular proteins that are exposed upon unfolding. Crucially TPE-MI does not become fluorescent when conjugated to soluble glutathione. We find that TPE-MI fluorescence is enhanced upon reaction with cellular proteomes under conditions promoting accumulation of unfolded proteins. TPE-MI reactivity can be used to track which proteins expose more cysteine residues under stress through proteomic analysis. We show that TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin treatment of the malaria parasites Plasmodium falciparum . TPE-MI therefore holds promise as a tool to probe proteostasis mechanisms in disease.
Enhanced Emission of Molybdenum Disulfide by Organic–Inorganic Hybrid Heterojunctions
Publisher: American Chemical Society (ACS)
Date: 21-07-2023
Dissolution kinetics of zinc oxide nanoparticles: real-time monitoring using a Zn2+-specific fluorescent probe
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9EN00553F
Abstract: A fluorescence method was employed to monitor the real-time dissolution kinetics of zinc oxide nanoparticles.
Unraveling the photophysical and semiconducting properties of color converter luminogens with aggregation induced emission characteristics
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0TC03632C
Abstract: Aggregation-induced emission (AIE) has attracted increasing attention in recent years in the search for luminescent materials with biomedical and optoelectronic applications.
Modular Peptide Probe for Pre/Intra/Postoperative Therapeutic to Reduce Recurrence in Ovarian Cancer
Publisher: American Chemical Society (ACS)
Date: 11-11-2020
Remarkable Multichannel Conductance of Novel Single-Molecule Wires Built on Through-Space Conjugated Hexaphenylbenzene
Publisher: American Chemical Society (ACS)
Date: 18-06-2018
DOI: 10.1021/ACS.NANOLETT.8B01082
Abstract: Through-bond conjugated molecules are the major frameworks for traditional molecular wires, while through-space conjugated units are rarely utilized and studied although they have shown unique conducting potential. Herein, we present novel single-molecule wires built on through-space conjugated hexaphenylbenzene. Their conductance, measured by the scanning tunneling microscopy based break-junction technique, increases with the improvement of through-space conjugation and finally reaches a remarkable value (12.28 nS) which greatly exceeds that of conventional through-bond conjugated counterpart (2.45 nS). The multichannel conducting model by integrating through-space and through-bond conjugations could be a promising strategy for the further design of robust single-molecule wires with advanced conductance and stability.
“Trojan Horse” Phototheranostics: Fine‐Engineering NIR‐II AIEgen Camouflaged by Cancer Cell Membrane for Homologous‐Targeting Multimodal Imaging‐Guided Phototherapy
Publisher: Wiley
Date: 02-07-2023
Abstract: Multimodal phototheranostics on the basis of a single molecule with one‐for‐all characteristics represents a convenient approach for effective cancer treatment. In this report, a versatile molecule featured by aggregation‐induced emission, namely DHTDP, synchronously enabling second near‐infrared (NIR‐II) fluorescence emission and efficient photothermal conversion is developed by elaborate structural modulation. By camouflaging DHTDP nanoparticles with cancer cell membrane, the resultant biomimetic nanoparticles exhibit significantly both facilitated delivery efficiency and homologous targeting capability, and afford precise imaging guidance and maximize therapeutic outcomes in form of NIR‐II fluorescence imaging (FLI)–photoacoustic imaging (PAI)–photothermal imaging (PTI) trimodal imaging‐guided photothermal therapy (PTT). This study presents the first ex le of biomimetic multimodal phototheranostics loaded by homogeneity‐targeting cell membrane, thus brings a new insight into the exploration of superior phototheranostics for practical cancer theranostics.
Highly Efficient Luminescent Liquid Crystal with Aggregation-Induced Energy Transfer
Publisher: American Chemical Society (ACS)
Date: 28-12-0008
Abstract: A luminescent liquid crystal molecule (TPEMes) with efficient solid-state emission is rationally constructed via the chemical conjugation of blue-emitting tetraphenylethene cores and luminescent mesogenic tolane moieties, which are both featured with aggregation-induced emission properties. As for this fluorophore, aggregation-induced energy transfer from the emissive tolane mesogens to the lighting-up tetraphenylethene units endows the molecule pure blue emission in the suspension and bulk state. Combining differential scanning calorimetry, polarized optical microscope, and one-dimensional X-ray diffraction (1D XRD) experiments, the compound TPEMes is deduced to adapt thermodynamically more stable layered crystalline phase and can be "frozen" into a monotropic smectic mesophase due to kinetic reasons. As a result of more dense packing of TPEMes in the crystalline phase indicated by 1D XRD, the luminescence of TPEMes in crystalline phase blue-shifted by 17 nm relative to the metastable mesophase.
Exploration of high-performance light-conversion agents based on cyanostilbene and phenanthrenecarbonitrile backbones: E/Z and position isomerism, high-contrast Michael addition reaction
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1TC02405A
Abstract: High-contrast Michael addition and intramolecular photocyclization, excellent photostability and significantly enhanced transmittance.
Palladium/Benzoic Acid-Catalyzed Regio- and Stereoselective Polymerization of Internal Diynes and Diols through C(sp3)–H Activation
Publisher: American Chemical Society (ACS)
Date: 13-08-2019
DOI: 10.1021/ACSMACROLETT.9B00448
Abstract: The C-H activation has been a hot research area in organic chemistry, and the most difficult one is the C(sp
Direct Conversion from Carbon Dioxide to Luminescent Poly(β-alkoxyacrylate)s via Multicomponent Tandem Polymerization-Induced Emission
Publisher: American Chemical Society (ACS)
Date: 19-05-2021
DOI: 10.26434/CHEMRXIV.14601729
Abstract: Using carbon dioxide (CO sub /sub ) as a feedstock to synthesize various polymers has drawn much attention. One-pot multicomponent tandem polymerization (MCTP) with great synthetic simplicity and efficiency is a powerful strategy for the synthesis of new CO sub /sub -based luminescent polymers. In this work, we successfully developed a new one-pot MCTP combining three sequential carboxylation-cyclization-esterification reactions of CO sub /sub , diynes and alkyl dihalides to direct fixing CO sub /sub into luminescent polymers with aggregation-enhanced emission (AEE) property. This MCTP could be facilely carried out in i N,N /i -dimethylacetamide in the presence of a cheap catalyst CuI and an organic base 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene under atmospheric pressure. A series of poly( i β /i -alkoxyacrylate)s with well-defined structures, high molecular weights ( i M /i sub w /sub up to 15 400) were obtained in high yields (up to 96%). The resultant polymers possess good thermal stability with high decomposition temperature and high char yield. Due to polymerization-induced emission (PIE) behavior, the non-luminescent monomers could be converted to luminescent poly( i β /i -alkoxyacrylate)s with AEE features. Thus, this work provides a new pathway to directly transform CO sub /sub into luminescent polymers via a one-pot MCTP strategy.
The AIE‐Active Dual‐Cationic Molecular Engineering: Synergistic Effect of Dark Toxicity and Phototoxicity for Anticancer Therapy
Publisher: Wiley
Date: 09-09-2021
Abstract: The development of anticancer therapy is significant to human health but remains a huge challenge. Photodynamic therapy (PDT), inducing the synergistic mitochondrial dysfunction in cancer cells is a promising approach but suffer from the low efficiency in hypoxic microenvironment and deep‐seated tumors. Herein, to improve the outcomes of PDT for cancer treatment, a series of red fluorophores consisting of dual‐cationic triphenylphosphonium‐alkylated pyridinium and (substituted) triphenylamine are prepared as organelle‐targeting antitumor photosensitizers (PSs) with aggregation‐induced emission characteristics. These PSs can selectively accumulate at the mitochondria or lysosomes of cancer cells with both dark‐ and photo‐cytotoxicity, making them possess excellent killing effect on cancer cells and efficient inhibition of tumor growth in living mice. This study brings about new insight into the development of powerful cancer treatment.
Luminescent Neutral Cyclometalated Iridium(III) Complexes Featuring a Cubic Polyhedral Oligomeric Silsesquioxane for Lipid Droplet Imaging and Photocytotoxic Applications
Publisher: American Chemical Society (ACS)
Date: 16-07-2021
Multicationic AIEgens for unimolecular photodynamic theranostics and two-photon fluorescence bioimaging
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0QM00119H
Abstract: This work reports multicationic AIEgens for unimolecular photodynamic theranostics, and an investigation of the relationship between their structures and activities, including PDT performance, 2-photon bioimaging, and self-reporting characteristics.
Real-Time 3D Framework Tracing of Extracellular Polymeric Substances by an AIE-Active Nanoprobe
Publisher: American Chemical Society (ACS)
Date: 05-11-2021
DOI: 10.1021/ACSSENSORS.1C01821
Abstract: Extracellular polymeric substances (EPS) are produced by many microorganisms and play an essential role in physiological systems such as nutrient storage and stress resistance. Besides, EPS show great potential in biomedical and therapeutic applications due to their biocompatibility and biodegradability. In situ noninvasive monitoring of the EPS produced by microorganisms is thus critical but has not yet been achieved. Herein, we developed a novel aggregation-induced emission (AIE) active nanoprobe enabling in situ visualization of the EPS distribution produced by various microorganisms (cyanobacteria, yeast, freshwater, and marine phytoplankton). The synthesized AIE-active nanoprobe displayed excellent specificity and precision for the staining of EPS, as well as strong photostability, showing great advantage in sensing the EPS in living organisms. With the application of this novel probe, the three-dimensional (3D) framework of EPS distribution was visualized under different environmental conditions (temperature, light intensity, nutrition, and pH). The EPS distribution was found to correlate significantly with the metal tolerance and cyanobacterial photosynthesis capability. Collectively, this study proposed an AIE-active nanoprobe for visualizing the EPS distribution and quantifying the EPS thickness/volume, and has significant implications in understanding the physiological functions of microorganisms.
Novel Organic Phototransistor-Based Nonvolatile Memory Integrated with UV-Sensing/Green-Emissive Aggregation Enhanced Emission (AEE)-Active Aromatic Polyamide Electret Layer
Publisher: American Chemical Society (ACS)
Date: 07-05-2018
Abstract: A novel aggregation enhanced emission (AEE)-active polyamide TPA-CN-TPE with a high photoluminesence characteristic was successfully synthesized by the direct polymerization of 4-cyanotriphenyl diamine (TPA-CN) and tetraphenylethene (TPE)-containing dicarboxylic acid. The obtained luminescent polyamide plays a significant role as the polymer electret layer in organic field-effect transistors (OFETs)-type memory. The strong green emission of TPA-CN-TPE under ultraviolet (UV) irradiation can be directly absorbed by the pentacene channel, displaying a light-induced programming and voltage-driven erasing organic phototransistor-based nonvolatile memory. Memory window can be effectively manipulated between the programming and erasing states by applying UV light illumination and electrical field, respectively. The photoinduced memory behavior can be maintained for over 10
Oxygen Quenching-Resistant Nanoaggregates with Aggregation-Induced Delayed Fluorescence for Time-Resolved Mapping of Intracellular Microviscosity
Publisher: American Chemical Society (ACS)
Date: 23-03-2022
Abstract: Microviscosity is a fundamental parameter in the biophysics of life science and governs numerous cellular processes. Thus, the development of real-time quantitative monitoring of microviscosity inside cells is important. The traditional probes for detecting microviscosity via time-resolved luminescence imaging (TRLI) are generally disturbed by autofluorescence or surrounding oxygen in cells. Herein, we developed loose packing nanoaggregates with aggregation-induced delayed fluorescence (FKP-POA and FKP-PTA) and free from the effect of oxygen and autofluorescence for viscosity mapping via TRLI. The feasibility of FKP-PTA nanoparticles (NPs) for microviscosity mapping through TRLI was demonstrated by monitoring the variation of microviscosity inside HepG2 cancer cells, which demonstrated a value change from 14.9 cP to 216.9 cP during the apoptosis. This indicates that FKP-PTA NP can be used as a probe for cellular microviscosity mapping to help people to understand the physiologically dynamic microenvironment. The present results are expected to promote the advancement of diagnostic and therapeutic methods to cope with related diseases.
Catalyst-Free Click Polymerization of Thiol and Activated Internal Alkynes: A Facile Strategy toward Functional Poly(β-thioacrylate)s
Publisher: American Chemical Society (ACS)
Date: 08-06-2020
A Facile Strategy To Prepare Smart Coatings with Autonomous Self-Healing and Self-Reporting Functions
Publisher: American Chemical Society (ACS)
Date: 30-12-2019
Abstract: Herein, we report a smart coating with autonomous self-healing and self-reporting functions by simple integration of one-component microcapsules into the matrix without external intervention. The microcapsules containing hexamethylene diisocyanate (HDI) solution of aggregation-induced emission luminogens (AIEgens) were synthesized, and their properties, such as their composition, thermal stability, morphology, and damage-indicating ability, were investigated systematically. The AIEgen/HDI microcapsule-embedded coatings display adaptive self-repair of scratches and simultaneous high-contrast indication of the healed damage. Two commercialized AIEgens, tetraphenylethylene (TPE) and its derivative with dimethoxyl and benzylidene-methyloxazolone moieties (DM-TPE-BMO), were utilized as ex les to demonstrate the feasibility of this concept in erse polymer matrixes (including blue autofluorescent matrixes). It was found that the content of AIEgens can even be lowered to 0.05 wt %. This facile, economical, and feasible strategy toward the dual functions of self-repairing and self-sensing provides a new route for enhancing the longevity and reliability of polymer coatings, which is appealing and of great importance in practical applications.
Highly Stable Organic Small Molecular Nanoparticles as an Advanced and Biocompatible Phototheranostic Agent of Tumor in Living Mice
Publisher: American Chemical Society (ACS)
Date: 12-07-2017
Abstract: Near-infrared (NIR)-absorbing organic small molecules hold great promise as the phototheranostic agents for clinical translation by virtue of their intrinsic advantages such as well-defined chemical structure, high purity, and good reproducibility. However, most of the currently available ones face the challenges in varying degrees in terms of photothermal instability, and photobleaching/reactive oxygen nitrogen species (RONS) inresistance, which indeed impair their practical applications in precise diagnosis and treatment of diseases. Herein, we developed highly stable and biocompatible organic nanoparticles (ONPs) for effective phototheranostic application by design and synthesis of an organic small molecule (namely TPA-T-TQ) with intensive absorption in the NIR window. The TPA-T-TQ ONPs with no noticeable in vivo toxicity possess better capacities in photothermal conversion and photoacoustic imaging (PAI), as well as show far higher stabilities including thermal hotothermal stabilities, and photobleaching/RONS resistances, when compared with the clinically popularly used indocyanine green. Thanks to the combined merits, the ONPs can serve as an efficient probe for in vivo PAI in a high-contrast manner, which also significantly causes the stoppage of tumor growth in living mice through PAI-guided photothermal therapy. This study thus provides an insight into the development of advanced NIR-absorbing small molecules for practical phototheranostic applications.
Circularly polarized luminescence from AIEgens
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9TC07022B
Abstract: This work systematically summarizes recent advances in circularly polarized luminescence (CPL) based on aggregation-induced emission luminogens (AIEgens).
Fabrics Attached with Highly Efficient Aggregation-Induced Emission Photosensitizer: Toward Self-Antiviral Personal Protective Equipment
Publisher: American Chemical Society (ACS)
Date: 27-07-2021
Abstract: Personal protective equipment (PPE) is vital for the prevention and control of SARS-CoV-2. However, conventional PPEs lack virucidal capabilities and arbitrarily discarding used PPEs may cause a high risk for cross-contamination and environmental pollution. Recently reported photothermal or photodynamic-mediated self-sterilizing masks show bactericidal-virucidal abilities but have some inherent disadvantages, such as generating unbearable heat during the photothermal process or requiring additional ultraviolet light irradiation to inactivate pathogens, which limit their practical applications. Here, we report the fabrication of a series of fabrics (derived from various PPEs) with real-time self-antiviral capabilities, on the basis of a highly efficient aggregation-induced emission photosensitizer (namely, ASCP-TPA). ASCP-TPA possesses facile synthesis, excellent biocompatibility, and extremely high reactive oxygen species generation capacity, which significantly outperforms the traditional photosensitizers. Meanwhile, the ASCP-TPA-attached fabrics (ATaFs) show tremendous photodynamic inactivation effects against MHV-A59, a surrogate coronavirus of SARS-CoV-2. Upon ultralow-power white light irradiation (3.0 mW cm -2 ), .999% virions (5 log) on the ATaFs are eliminated within 10 min. Such ultralow-power requirement and rapid virus-killing ability enable ATaFs-based PPEs to provide real-time protection for the wearers under indoor light irradiation. ATaFs' virucidal abilities are retained after 100 washings or continuous exposure to office light for 2 weeks, which offers the benefits of reusability and long-term usability. Furthermore, ATaFs show no toxicity to normal skin, even upon continuous high-power light illumination. This self-antiviral ATaFs-based strategy may also be applied to fight against other airborne pathogens and holds huge potential to alleviate global PPE supply shortages.
Steering the Topological Defects in Amorphous Laser-Induced Graphene for Direct Nitrate-to-Ammonia Electroreduction
Publisher: American Chemical Society (ACS)
Date: 09-09-2022
D‐type neuropeptide decorated AIEgen/RENP hybrid nanoprobes with light‐driven ROS generation ability for NIR‐II fluorescence imaging‐guided through‐skull photodynamic therapy of gliomas
Publisher: Wiley
Date: 31-07-2023
DOI: 10.1002/AGT2.396
Abstract: Glioma is one of the most common malignant tumors of the central nervous system, leading high mortality rates in human. Aggregation‐induced emission (AIE) photosensitizers‐based photodynamic therapy (PDT) has emerged as a promising therapeutic strategy for least‐invasive treatment of glioma, which involves local irradiation of the tumor using an external near‐infrared (NIR) laser. Unfortunately, most AIE photosensitizers suffered from poorly penetration of the visible light excitation, bad spatiotemporal resolution in deep tissues and low efficient blood‐brain barrier (BBB) crossing ability, which greatly limited the clinical practice of AIE photosensitizers for especially deep‐seated brain tumor treatment. In this work, we developed a multifunctional NIR‐driven theranostic agent through hybrid of AIE photosensitizers TIND with rare‐earth doping nanoparticles (RENPs) NaGdF 4 :Nd/Yb/Tm with up/down dual‐mode conversion luminescence. The theranostic agent was further decorated with D‐type neuropeptide D NPY for crossing BBB and targeting glioma. Under the 808‐nm light irradiation, the down‐conversion NIR‐II luminescence could indicate the position glioma and the upconversion NIR‐I luminescence could trigger the AIE photosensitizers producing reactive oxygen species to inhibit orthotopic glioma tumor growth in situ. These results demonstrate that the integration of D‐type neuropeptide, AIE photosensitizers and RENPs could be promising candidates for in vivo NIR‐II fluorescence image‐guided through‐skull PDT treatments of brain tumors.
Aggregation caused quenching to aggregation induced emission transformation: a precise tuning based on BN-doped polycyclic aromatic hydrocarbons toward subcellular organelle specific imaging
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2SC00380E
Abstract: A one-stone-two-birds strategy including simultaneous exploration of reactivity and tuning of the optical and electronic properties for BN-fused polycyclic aromatics through flexible regioselective functionalization engineering is presented.
How to Manipulate Through-Space Conjugation and Clusterolumi-nescence of Simple AIEgens with Isolated Phenyl Rings?
Publisher: American Chemical Society (ACS)
Date: 13-04-2021
DOI: 10.26434/CHEMRXIV.14400953
Abstract: a Apart from the traditional through-bond conjugation (TBC), through-space conjugation (TSC) is gradually proved as another important interaction in photophysical processes, especially for the recent observation of clusteroluminescence from nonconjugated molecules. /a Herein, a simple and nonconjugated triphenylmethane (TPM) and its derivatives with electron-donating and electron-withdrawing groups were synthesized /a , and their photophysical properties were systematically studied. a TPM was characterized with visible clusteroluminescence due to the intramolecular TSC. Experimental and theoretical results showed that the introduction of electron-donating groups into TPM could /a a red-shift /a the wavelength and increase the efficiency of clusteroluminescence simultaneously, due to the increased electronic density and stabilization of TSC. However, TPM derivatives with electron-withdrawing groups showed inefficient or even quenched clusteroluminescence caused by the vigorous excited-state intramolecular motion and intermolecular photoinduced electron transfer process. This work provides a reliable strategy to manipulate TSC and clusteroluminescence.
Fluorescent Sensors Based on Aggregation-Induced Emission: Recent Advances and Perspectives
Publisher: American Chemical Society (ACS)
Date: 25-09-2017
DOI: 10.1021/ACSSENSORS.7B00551
Abstract: Fluorescent sensors with advantages of excellent sensitivity, rapid response, and easy operation are emerging as powerful tools in environmental monitoring, biological research, and disease diagnosis. However, conventional fluorophores featured with π-planar structures usually suffer from serious self-quenching in the aggregated state, poor photostability, and small Stokes' shift. In contrast to conventional aggregation-caused quenching (ACQ) fluorophores, the newly emerged aggregation-induced emission fluorogens (AIEgens) are featured with high emission efficiency in the aggregated state, which provide unique opportunities for various sensing applications with advantages of high signal-to-noise ratio, strong photostability, and large Stokes' shift. In this review, we will first briefly give an introduction of the AIE concept and the turn-on sensing principles. Then, we will discuss the recent ex les of AIE sensors according to types of analytes. Finally, we will give a perspective on the future developments of AIE sensors. We hope this review will inspire more endeavors to devote to this emerging world.
Molecular Crystal Engineering of Organic Chromophores for NIR-II Fluorescence Quantification of Cerebrovascular Function
Publisher: American Chemical Society (ACS)
Date: 14-02-2022
Abstract: Although molecular design strategies for highly bright near-infrared II (NIR-II) fluorophores were proposed, the lack of solid structural identification (single crystal) hinders the further development of this field. This thorny issue is addressed by performing the structure-function relationship of NIR-II dyes, as confirmed by molecular single crystal engineering. Single crystal structure analysis confirms that twisted architectures (large dihedral angles ∼70°) and loose packing patterns (intermolecular distance of ∼3.4-4.5 Å) are key elements to enhance the absolute quantum yield (QY) in the solid state. Through regulating donor-acceptor distance and donor-acceptor interactions, the resultant well-defined TBP-
Simultaneously achieving high capacity storage and multilevel anti-counterfeiting using electrochromic and electrofluorochromic dual-functional AIE polymers
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1SC00722J
Abstract: By using electrical stimuli-responsive AIE polymers, dual-mode display devices, multidimensional information storage and anti-counterfeiting devices were constructed.
Achieving Color‐Tunable and Time‐Dependent Organic Long Persistent Luminescence via Phosphorescence Energy Transfer for Advanced Anti‐Counterfeiting
Publisher: Wiley
Date: 30-10-2023
Abstract: Organic ultralong room‐temperature phosphorescence (RTP) materials have promising applications in anti‐counterfeiting. To improve the encryption level, the exploration of organic materials with tunable solid‐state long persistent luminescence is in urgent need. Herein, a series of organic ultralong RTP polymeric systems are prepared by doping versatile indolocarbazole isomers into the poly(vinyl alcohol) (PVA) matrix. Notably, the doping film 11,12‐ICz@PVA exhibits excellent RTP property with an ultralong lifetime of 2.04 s and a high phosphorescence quantum yield of 44.1%. Theoretical calculations reveal that this excellent RTP property can be attributed to the strong electrostatic attraction resulting from the synergistic double hydrogen‐bond between the isomer 11,12‐ICz and PVA matrix. More impressively, color‐tunable and time‐dependent long persistent luminescence is successfully achieved through efficient phosphorescence energy transfer between the indolocarbazole isomers with ultralong blue RTP emissions and commercially available fluorescent dyes with emission colors ranging from green to red doped into the PVA matrix. Besides, ersified encryption patterns are fabricated to demonstrate the promising applications of these water‐soluble doping PVA systems with tunable solid‐state persistent luminescence in advanced anti‐counterfeiting technology.
A flexible topo-optical sensing technology with ultra-high contrast
Publisher: Springer Science and Business Media LLC
Date: 19-03-2020
DOI: 10.1038/S41467-020-15288-8
Abstract: Elastic folding, a phenomenon widely existing in nature, has attracted great interests to understand the math and physical science behind the topological transition on surface, thus can be used to create frontier engineering solutions. Here, we propose a topo-optical sensing strategy with ultra-high contrast by programming surface folds on targeted area with a thin optical indicator layer. A robust and precise signal generation can be achieved under mechanical compressive strains ( .4). This approach bridges the gap in current mechano-responsive luminescence mechanism, by utilizing the unwanted oxygen quenching effect of Iridium-III (Ir-III) fluorophores to enable an ultra-high contrast signal. Moreover, this technology hosts a rich set of attractive features such as high strain sensing, encoded logic function, direct visualisation and good adaptivity to the local curvature, from which we hope it will enable new opportunities for designing next generation flexible/wearable devices.
Boosting external quantum efficiency to 38.6% of sky-blue delayed fluorescence molecules by optimizing horizontal dipole orientation
Publisher: American Association for the Advancement of Science (AAAS)
Date: 22-10-2021
Abstract: Highly efficient sky-blue organic luminescent materials for the application in organic light-emitting diodes are developed.
Red/NIR‐Emissive Benzo[d]imidazole‐Cored AIEgens: Facile Molecular Design for Wavelength Extending and In Vivo Tumor Metabolic Imaging
Publisher: Wiley
Date: 15-10-2018
Abstract: Aggregation-induced emission (AIE) luminogens (AIEgens) with red/near-infrared (NIR) emissions are appealing for applications in optoelectronics and biomedical engineering owing to their intrinsic advantages of efficient solid-state emission, low background, and deep tissue penetration. In this context, an AIEgen with long-wavelength emission is synthesized by introducing tetraphenylethene (TPE) to the periphery of electron-deficient spiro-benzo[d]imidazole-2,1'-cyclohexane (BI). The resulting AIEgen, abbreviated as 2TPE-BI, adopts a donor-acceptor structure and shows bathochromic absorption and emission with a larger Stokes shift of 157 nm in acetonitrile than that based on benzo[c][1,2,5]thiadiazole. It also exhibits a high solid-state fluorescence quantum yield of 56.6%. By further insertion of thiophene to its molecular structure generates 2TPE-2T-BI with higher conjugation and NIR emission. 2TPE-2T-BI can be fabricated into AIE dots for in vivo metabolic labeling through bio-orthogonal click chemistry. These results open a new approach for facile construction of long-wavelength emissive AIEgens based on the BI core.
Mechanochromic Fluorescent Polymers Enabled by AIE Processes
Publisher: Wiley
Date: 10-07-2020
Time-dependent solid-state molecular motion and colour tuning of host-guest systems by organic solvents
Publisher: Springer Science and Business Media LLC
Date: 07-01-2020
DOI: 10.1038/S41467-019-13844-5
Abstract: Host-guest complex solid state molecular motion is a critical but underexplored phenomenon. In principle, it can be used to control molecular machines that function in the solid state. Here we describe a solid state system that operates on the basis of complexation between an all-hydrocarbon macrocycle, D 4d -CDMB-8 , and perylene. Molecular motion in this solid state machine is induced by exposure to organic solvents or grinding and gives rise to different co-crystalline, mixed crystalline, or amorphous forms. Distinct time-dependent emissive responses are seen for different organic solvents as their respective vapours or when the solid forms are subject to grinding. This temporal feature allows the present D 4d -CDMB-8 ⊃perylene-based system to be used as a time-dependent, colour-based 4th dimension response element in pattern-based information codes. This work highlights how dynamic control over solid-state host-guest molecular motion may be used to induce a tuneable temporal response and provide materials with information storage capability.
An ideal platform of light-emitting materials from phenothiazine: facile preparation, tunable red/NIR fluorescence, bent geometry-promoted AIE behaviour and selective lipid-droplet (LD) tracking abili
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9TC00143C
Abstract: An AIE platform based on phenothiazine with bright red-NIR emission was facilely synthesized and the mechanism/application was also investigated.
Endoplasmic Reticulum-Targeted Aggregation-Induced Emission Luminogen for Synergetic Tumor Ablation with Glibenclamide
Publisher: American Chemical Society (ACS)
Date: 30-10-2023
A Photoactivatable AIEgen for Selective Imaging and Killing of Estrogen Receptor-Positive Cells
Publisher: American Chemical Society (ACS)
Date: 18-08-2022
High-contrast luminescence dependent on polymorphism and mechanochromism of AIE-active (4-(phenothiazin-10-yl)phenyl)(pyren-1-yl)methanone
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9TC05064G
Abstract: The polymorphism and mechanochromism properties of a new AIEgen are studied.
Achieving diversified emissive behaviors of AIE, TADF, RTP, dual-RTP and mechanoluminescence from simple organic molecules by positional isomerism
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2TC01857H
Abstract: A facile strategy to achieve simple organic isomers featuring ersified emissive behaviors of AIE, TADF, RTP, dual-RTP, and ML via a subtle variation in the substitution position is presented for the first time.
Palladium‐Catalyzed Polymerization of Perfluoroalkyl Iodide and Aromatic Alkynes for the Synthesis of Perfluoroalkylated Poly(enyne)s
Publisher: Wiley
Date: 03-10-2023
Abstract: Fluoropolymers with unique structures, high chemical stability, heat resistance, hydrophobicity, and insulation to electricity, have attracted much attention, owing to their applications in low surface energy coatings, dielectric materials, solid electrolytes, ion exchange membranes, and so on. However, the synthetic approaches for fluoropolymers are quite limited, and it is crucial to develop new synthetic approaches for the pursuing of new fluoropolymer structures. Herein, a series of soluble conjugated fluoropolymers with unique 1,3‐enyne structures embedded in the polymer chain and perfluoroalkyl group as sidechains are synthesized in high yields of up to 96% from a palladium‐catalyzed polymerization of aromatic terminal diynes and perfluorobutyl iodide in 1,4‐dioxane at 80 °C using K 2 CO 3 as the base. The chemical structures of the fluoropolymers are fully characterized by gas permeation chromatography (GPC), 1 H, 13 C, 19 F NMR, and IR spectra, together with the comparison with the spectra of the small molecular model compound, confirming their expected polymer structures with high selectivity, high molecular weights of up to 60 500 g mol −1 , good solubility, high thermal resistance, and hydrophobicity. This efficient polymerization provides a convenient tool for the preparation of fluoropolymers, promoting the development of polymer synthetic methodology and the exploration of new fluoropolymer structures and materials.
Precise Planar-Twisted Molecular Engineering to Construct Semiconducting Polymers with Balanced Absorption and Quantum Yield for Efficient Phototheranostics
Publisher: American Association for the Advancement of Science (AAAS)
Date: 2023
Abstract: Semiconducting polymers (SPs) have shown great feasibility as candidates for near-infrared-II (NIR-II) fluorescence imaging-navigated photothermal therapy due to their strong light-harvesting ability and flexible tunability. However, the fluorescence signal of traditional SPs tends to quench in their aggregate states owing to the strong π–π stacking, which can lead to the radiative decay pathway shutting down. To address this issue, aggregation-induced emission effect has been used as a rational tactic to boost the aggregate-state fluorescence of NIR-II emitters. In this contribution, we developed a precise molecular engineering tactic based on the block copolymerizations that integrate planar and twisted segments into one conjugated polymer backbone, providing great flexibility in tuning the photophysical properties and photothermal conversion capacity of SPs. Two monomers featured with twisted and planar architectures, respectively, were tactfully incorporated via a ternary copolymerization approach to produce a series of new SPs. The optimal copolymer (SP2) synchronously shows desirable absorption ability and good NIR-II quantum yield on the premise of maintaining typical aggregation-induced emission characteristics, resulting in balanced NIR-II fluorescence brightness and photothermal property. Water-dispersible nanoparticles fabricated from the optimal SP2 show efficient photothermal therapeutic effects both in vitro and in vivo. The in vivo investigation reveals the distinguished NIR-II fluorescence imaging performance of SP2 nanoparticles and their photothermal ablation toward tumor with prominent tumor accumulation ability and excellent biocompatibility.
A Versatile 980 nm Absorbing Aggregation‐Induced Emission Luminogen for NIR‐II Imaging‐Guided Synergistic Photo‐Immunotherapy Against Advanced Pancreatic Cancer
Publisher: Wiley
Date: 24-06-2022
Abstract: To address urgent tasks in the treatment of advanced deep‐seated tumors, a 980 nm absorbing agent with aggregation‐induced emission tendency, namely TPE‐BT‐BBTD, which simultaneously possesses the longest absorption wavelength among all the reported AIE molecules is developed. The functionality of deep near‐infrared‐II fluorescence imaging (NIR‐II FLI) and outstanding photothermal performance is well‐tailored for advanced pancreatic cancer treatment. With the covalent attachment of the programmed death‐ligand 1 (αPD‐L1) antibody, αPD‐L1@TPE‐BT‐BBTD nanoparticles show precise tumor targeting and excellent immunosuppression reversal ability. Following local photothermal therapy, immunogenic tumor vaccination is induced to trigger the infiltration of cytotoxic T lymphocytes (CTLs) in tumors. With the decreased FoxP3 + Treg cells and M2‐like macrophages that are reversed by αPD‐L1, CTLs activity is further enhanced with more production of granzyme B (GrB), which much accurately leads to tumor apoptosis and effectively suppressed spontaneous metastases. Overall, αPD‐L1@TPE‐BT‐BBTD nanoparticles based NIR‐II FLI‐mediated photo‐immunotherapy is able to significantly improve the control of primary tumor and metastasis in the treatment of advanced deep‐seated tumors.
Natural-Killer-Cell-Inspired Nanorobots with Aggregation-Induced Emission Characteristics for Near-Infrared-II Fluorescence-Guided Glioma Theranostics
Publisher: American Chemical Society (ACS)
Date: 21-08-2020
Through‐Space CBr···π Halogen Interaction: Efficient Modulation of Reaction‐Based Photochromism and Photoluminescence at Crystalline States for Irradiation Time‐Dependent Anti‐Counterfeiting
Publisher: Wiley
Date: 30-11-2020
Blood Circulation Assessment by Steadily Fluorescent Near-Infrared-II Aggregation-Induced Emission Nano Contrast Agents
Publisher: American Chemical Society (ACS)
Date: 20-09-2023
In Situ Generation of Azonia-Containing Polyelectrolytes for Luminescent Photopatterning and Superbug Killing
Publisher: American Chemical Society (ACS)
Date: 20-06-2019
DOI: 10.1021/JACS.9B04757
Abstract: Polyelectrolytes play an important role in both natural biological systems and human society, and their synthesis, functional exploration, and profound application are thus essential for biomimicry and creating new materials. In this study, we developed an efficient synthetic methodology for
Manipulation of Molecular Aggregation States to Realize Polymorphism, AIE, MCL, and TADF in a Single Molecule
Publisher: Wiley
Date: 23-08-2018
Abstract: Multifunctional emitting materials are scarce and need to be further explored. Now, a newly anthraquinone derivative, 2-(phenothiazine-10-yl)-anthraquinone (PTZ-AQ) was designed and synthesized and found to demonstrate polymorphism, multi-color emission, aggregation-induced emission (AIE), mechanochromic luminescence (MCL), and thermally activated delayed fluorescence (TADF) in its different solid forms. It is shown for the first time that TADF properties of a compound can be systematically tuned via its aggregation state. The optimized PTZ-AQ crystal shows a small singlet-triplet energy splitting of 0.01 eV and exhibits red TADF with a photoluminescence quantum yield as high as 0.848. This study shows that the unique multiple functions can be integrated into one single compound through controlling the aggregation states, which provides a new strategy for the investigation and application of multifunctional organic materials.
More is better: aggregation induced luminescence and exceptional chirality and circularly polarized luminescence of chiral gold clusters
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0QM00552E
Abstract: The AIE effect of Au clusters could induce both luminescence and chirality, and further facilitated their enhancements, which resulted in desirable CPL.
How Do Molecular Motions Affect Structures and Properties at Molecule and Aggregate Levels?
Publisher: American Chemical Society (ACS)
Date: 06-2021
DOI: 10.26434/CHEMRXIV.14703822
Abstract: Experimental and theoretical analysis demonstrated that the active intramolecular motions in the excited state of all molecules at single molecule level imparted them with more twisted structural conformations and weak emission. However, owing to the restriction of intramolecular motions in the nano/macro aggregate state, all the molecules assumed less twisted conformations with bright emission. Synergic strong and weak intermolecular interactions allowed their crystals to undergo reversible deformation, which effectively solved the problem of the brittles of organic crystals, meanwhile imparted them with excellent elastic performance.
Fluorogenic Detection and Characterization of Proteins by Aggregation-Induced Emission Methods
Publisher: Wiley
Date: 07-02-2019
Abstract: Protein is one of the four most important biomacromolecules in living systems. The detection, quantification, localization, and characterization of proteins is essential for an understanding of biological fundamentals, as well as for the diagnostics and treatment of protein-related diseases. By using intrinsic and extrinsic fluorescence, different techniques have been established to study proteins, many of which are now being routinely used in research laboratories and clinics. This review summarizes the applications of aggregation-induced emission (AIE) fluorescence in protein science. In contrast to traditional fluorescent dyes, the activation of AIE dyes is mainly attributed to the restriction of intramolecular motions. This unique turn-on mechanism of AIE dyes allows researchers to develop novel fluorogenic strategies for sensitive, selective, and reliable analysis of proteins. This review focuses on introducing AIE strategies for 1) detection, localization, and quantification of proteins 2) probing polymer conformational transitions of proteins 3) characterization of protein-ligand interactions and 4) evaluation of enzyme activities. Perspectives and challenges with respect to this emerging field of protein characterization are offered.
Novel Quinolizine AIE System: Visualization of Molecular Motion and Elaborate Tailoring for Biological Application**
Publisher: Wiley
Date: 25-01-2022
Abstract: Molecular motions are ubiquitous in nature and they immutably play intrinsic roles in all actions. However, exploring appropriate models to decipher molecular motions is an extremely important but very challenging task for researchers. Considering aggregation‐induced emission (AIE) luminogens possess their unique merits to visualize molecular motions, it is particularly fascinating to construct new AIE systems as models to study molecular motion. Herein, a novel quinolizine (QLZ) AIE system was constructed based on the restriction intramolecular vibration (RIV) mechanism. It was demonstrated that QLZ could act as an ideal model to visualize single‐molecule motion and macroscopic molecular motion via fluorescence change. Additionally, further elaborate tailoring of this impressive core achieved highly efficient reactive oxygen species production and realized fluorescence imaging‐guided photodynamic therapy applications, which confirms the great application potential of this new AIE‐active QLZ core. Therefore, this work not only provides an ideal model to visualize molecular motion but also opens a new way for the application of AIEgens.
An AIE probe for long-term plasma membrane imaging and membrane-targeted photodynamic therapy
Publisher: Elsevier BV
Date: 04-2023
Free Radical-Mediated Intramolecular Photocyclization of AIEgens Based on 2,3-Diphenylbenzo[b]thiophene S,S-Dioxide
Publisher: American Chemical Society (ACS)
Date: 30-03-2023
DOI: 10.1021/JACS.2C12738
Multiscale Humidity Visualization by Environmentally Sensitive Fluorescent Molecular Rotors
Publisher: Wiley
Date: 16-10-2017
Abstract: Building humidity sensors possessing the features of erse-configuration compatibility, and capability of measurement of spatial and temporal humidity gradients is of great interest for highly integrated electronics and wearable monitoring systems. Herein, a visual sensing approach based on fluorescent imaging is presented, by assembling aggregation-induced-emission (AIE)-active molecular rotors into a moisture-captured network the resulting AIE humidity sensors are compatible with erse applications, having tunable geometries and desirable architectures. The invisible information of relative humidity (RH) is transformed into different fluorescence colors that enable direct observation by the naked eyes based on the twisted intramolecular charge-transfer effect of the AIE-active molecular rotors. The resulting AIE humidity sensors show excellent performance in terms of good sensitivity, precise quantitative measurement, high spatial-temporal resolution, and fast response/recovery time. Their multiscale applications, such as regional environmental RH detection, internal humidity mapping, and sensitive human-body humidity sensing are demonstrated. The proposed humidity visualization strategy may provide a new insight to develop humidity sensors for various applications.
An AIE-active theranostic probe for light-up detection of Aβ aggregates and protection of neuronal cells
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9TB00121B
Abstract: An AIE-active probe of Cur-N-BF 2 is developed for light-up detection of Aβ fibrils and plaques, inhibition of Aβ fibrillation, disassembly of preformed Aβ fibrils, and protection of neuronal cells.
Lipid Droplet-Specific Red Aggregation-Induced Emission Luminogens: Fast Light-Up of Gram-Positive Pathogens for Identification of Bacteria
Publisher: American Chemical Society (ACS)
Date: 18-07-2022
Facile Multicomponent Polymerizations toward Multifunctional Heterochain Polymers with α,β-Unsaturated Amidines
Publisher: American Chemical Society (ACS)
Date: 25-10-2021
Aggregation‐Induced Emission Active Probe for Light‐Up Detection of Anionic Surfactants and Wash‐Free Bacterial Imaging
Publisher: Wiley
Date: 17-02-2016
Abstract: Anionic surfactants are widely used in daily life and industries, but their residues can cause serious damage to the environment. The current detection methods for anionic surfactants suffer from various limitations and a new detection strategy is highly desirable. Based on 2-(2-hydroxyphenyl)benzothiazole fluorogen with aggregation-induced emission characteristics, we have developed a fluorescent probe HBT-C18 for selective and sensitive detection of anionic surfactants. By in situ formation of catanionic aggregates or micelles with anionic surfactants, the emission intensity of the HBT-C18 probe can increase with increasing keto/enol emission ratio through restriction of intramolecular motion and excited-state intramolecular proton-transfer mechanisms. The probe can also be used for wash-free imaging of bacteria enveloped by a negatively charged outer membrane. The results of this study provide a new strategy for sensitive detection of anionic surfactants and wash-free bacterial imaging.
From Molecular Achirality to Mesoscopic Helicity: Toward the Development of Circularly Polarized Luminescence‐Emitting Liquid Crystal Displays
Publisher: Wiley
Date: 09-09-2020
Riboflavin-Promoted In Situ Photoactivation of Dihydroalkaloid Prodrugs for Cancer Therapy
Publisher: American Chemical Society (ACS)
Date: 21-11-2022
DOI: 10.1021/ACS.JMEDCHEM.2C01262
Abstract: Cancer therapies usually suffer from poor targeting ability and serious side effects. Photoactivatable cancer therapy has the significant advantage of a high spatiotemporal resolution, but most photoactivatable prodrugs require decoration with stoichiometric photocleavable groups, which are only responsive to ultraviolet irradiation and suffer from low reaction efficiency. To tackle these challenges, we herein propose a photoactivation strategy with biogenic riboflavin as the photosensitizer to promote the in situ transformation of noncytotoxic dihydroalkaloid prodrugs dihydrochelerythrine (DHCHE), dihydrosanguinarine (DHSAN), and dihydronitidine (DHNIT) into anticancer alkaloid drugs chelerythrine (CHE), sanguinarine (SAN), and nitidine (NIT), respectively, which can efficiently kill cancer cells and inhibit in vivo tumor growth. Meanwhile, the photoactivatable transformation can be in situ monitored by green-to-red fluorescence conversion, which will contribute to easy controlling of the therapeutic dose. The proposed photoactivatable transformation mechanism was also explored by density functional theory (DFT) calculations. We believe this riboflavin-promoted and imaging-guided photoactivation strategy is promising for precise cancer therapy.
All-fluorescence white organic light-emitting diodes with record-beating power efficiencies over 130 lm W‒1 and small roll-offs
Publisher: Springer Science and Business Media LLC
Date: 02-09-2022
DOI: 10.1038/S41467-022-32967-W
Abstract: Improving power efficiency ( PE ) and reducing roll-off are of significant importance for the commercialization of white organic light-emitting diodes (WOLEDs) in consideration of energy conservation. Herein, record-beating PE of 130.7 lm W −1 and outstanding external quantum efficiency ( EQE ) of 31.1% are achieved in all-fluorescence two-color WOLEDs based on a simple sandwich configuration of emitting layer consisting of sky-blue and orange delayed fluorescence materials. By introducing a red fluorescence dopant, all-fluorescence three-color WOLEDs with high color rendering index are constructed based on an interlayer sensitization configuration, furnishing ultrahigh PE of 110.7 lm W −1 and EQE of 30.8%. More importantly, both two-color and three-color WOLEDs maintain excellent PE s at operating luminance with smaller roll-offs than the reported state-of-the-art WOLEDs, and further device optimization realizes outstanding comprehensive performances of low driving voltages, large luminance, high PE s and long operational lifetimes. The underlying mechanisms of the impressive device performances are elucidated by host-tuning effect and electron-trapping effect, providing useful guidance for the development of energy-conserving all-fluorescence WOLEDs.
Cell Cycle Control of Nanoplastics Internalization in Phytoplankton
Publisher: American Chemical Society (ACS)
Date: 22-06-2021
Abstract: Nanoparticles (NPs) for delivering chemotherapeutic drugs are now in clinical trials, and cellular uptake of NPs plays an important role in determining the drug delivery efficiency. Herein, we reported that the bioaccumulation and internalization of NPs were governed by the cell cycle. Specifically, we found that the bioaccumulation of NPs was more favored in the G 2 /M stages, followed by the S and G 0 /G 1 stages. We demonstrated that three key parameters-clathrin-mediated endocytosis capacity, algal cell membrane permeability, and exopolymer substance (EPS) thickness-were critical in the bioaccumulation of NPs during the cell cycling process. Over the 24-h average duration of cell cycle, clathrin-mediated endocytosis capacity was much higher at the S stage than that at the G 0 /G 1 and G 2 /M stages. Besides, cell membrane permeability was measured to be higher in S and G 2 /M stages while the lowest in G 0 /G 1 stage. We have also identified the change of EPS thickness during the 24-h cell cycle. Transition from G 0 /G 1 to S and G 2 /M induced the attenuation in EPS thickness, and the thinnest EPS was found at the end of mitosis. The cell cycle control NPs internalization were further verified by exposing Ag nanoparticles to algae at different cell cycle stages, confirming the important roles of EPS thickness and cell cycle control in the dynamic internalization processes. The present study highlights the important roles of cell cycle controlling the NPs bioaccumulation and internalization, with possible implications in maximizing NPs internalization efficiency while reducing the cost.
Microscopic visualization and mechanism investigation of the crystal jumping behavior of a cyclic chalcone derivative
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9QM00663J
Abstract: A highly emissive chalcone crystal which displays fantastic photo-induced jumping behavior is designed and the microscopic dynamic process is easily visualized and captured. The motion mechanism is demonstrated to be a [2+2] cycloaddition reaction.
Aggregation‐Induced Emission Luminogens Sensitized Quasi‐2D Hybrid Perovskites with Unique Photoluminescence and High Stability for Fabricating White Light‐Emitting Diodes
Publisher: Wiley
Date: 29-05-2021
Abstract: In order to endow quasi‐2D organic‐inorganic hybrid metal halide perovskites (quasi‐2D‐PVK) with superior performance, an aromatic organic ligand with aggregation‐induced emission (AIE) features is rationally designed and utilized for constructing distinctive quasi‐2D‐PVK materials. This AIE‐active ligand, TTPy‐NH 2 , well fits into the lattices of quasi‐2D‐PVK and leaves hydrophobic tails surrounding PVK layers, making the presented TTPy‐NH 2 /PVK film extraordinary in terms of both luminescence and stability. Benefiting from the prominent sensitization function and AIE tendency of TTPy‐NH 2 , the presented TTPy‐NH 2 /PVK film exhibits a high quantum yield of 62.2%, unique blue‐red dual‐emission property of both blue and red, high stability with the remnant of more than 94% fluorescence intensity remnant after 21 days. As a result, TTPy‐NH 2 /PVK film is capable of constituting high‐performance white light‐emitting diodes, with its color gamut reaching 138% of the National Television System Committee （NTSC） standard and the maximum efficiency is 105 lm W −1 at 20 mA. Evidently, a win‐win effect is achieved by the integration of AIE‐active ligands and quasi‐2D‐PVK, which are two of the most reputable solid‐state luminogens. This developed protocol thus opens up a new avenue for exploring the next generation of luminescent devices.
Quantifying the Energy Loss of Triplet Excitons on High‐Lying Triplet States to Develop High Efficiency Blue Fluorescence OLEDs Based on AIE Emitter
Publisher: Wiley
Date: 27-06-2023
Abstract: “Hot exciton” molecules that allow the transition of excitons from a high‐lying triplet state (T n , n≥ 2) to singlet states (S m , m≥1) by a reverse intersystem crossing (hRISC) process have become an effective strategy to achieve high efficiency fluorescence organic light emitting diodes (OLEDs). However, the understanding of the dynamic behavior of the “hot exciton” process is still very lacking. Herein, the exciton dynamics of an aggregation‐induced emission (AIE) molecule TPA‐An‐mPhCz with the “hot exciton” property are deeply investigated, and the proportion between hRISC and internal inversion (IC) of excitons on T n is successfully quantified by in situ transient electroluminescent measurements and theoretical calculation. It is found that the IC process increases severe energy loss of T n excitons. By introducing a triplet–triplet annihilation up‐conversion layer in the emissive layer to efficiently recapture the IC excitons and further doping a blue fluorescent emitter in the TPA‐An‐mPhCz layer to achieve high photoluminescence quantum yield (PLQY), the resulting OLED achieves a maximum external quantum efficiency of 12.5% with negligible efficiency roll‐off. More impressively, the operational lifetime LT 75 (lifetime to 75% of the initial luminance) of the device with efficient triplets utilization performs a remarkable 116 h under 1000 cd m −2 . This work provides the fundamentals for the design of hot exciton materials with efficient exciton utilization to develop efficient blue fluorescence OLEDs.
Sensitive and Specific Detection of l-Lactate Using an AIE-Active Fluorophore
Publisher: American Chemical Society (ACS)
Date: 24-10-2017
Abstract: l-Lactate is a vital biomarker for many diseases and physiological fatigue. An AIE-active fluorophore (TPE-HPro) is combined with l-lactate oxidase (LOx) to determine l-lactate in aqueous fluid. The assay shows excellent sensitivity and anti-interference performance with a limit of detection (LOD) of 5.5 μM. In addition, sensitive detection of l-lactate is achieved even in a protein-rich environment. It is proposed that quantification of l-lactate be performed at 20 or 60 min in the current method. These characteristics endow the fluorometric assay with great potential for biomedical diagnostics.
Corannulene‐Incorporated AIE Nanodots with Highly Suppressed Nonradiative Decay for Boosted Cancer Phototheranostics In Vivo
Publisher: Wiley
Date: 16-05-2018
Abstract: Fluorescent nanoparticles (NPs) based on luminogens with aggregation-induced emission characteristic (AIEgens), namely AIE dots, have received wide attention because of their antiquenching attitude in emission and reactive oxygen species (ROS) generation when aggregated. However, few reports are available on how to control and optimize their fluorescence and ROS generation ability. Herein, it is reported that enhancing the intraparticle confined microenvironment is an effective approach to advanced AIE dots, permitting boosted cancer phototheranostics in vivo. Formulation of a "rotor-rich" and inherently charged near-infrared (NIR) AIEgen with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] and corannulene-decorated PEG affords DSPE-AIE dots and Cor-AIE dots, respectively. Compared to DSPE-AIE dots, Cor-AIE dots show 4.0-fold lified fluorescence quantum yield and 5.4-fold enhanced ROS production, because corannulene provides intraparticle rigidity and strong interactions with the AIEgen to restrict the intramolecular rotation of AIEgen to strongly suppress the nonradiative decay and significantly facilitate the fluorescence pathway and intersystem crossing. Thus, it tremendously promotes phototheranostic efficacies in terms of NIR image-guided cancer surgery and photodynamic therapy using a peritoneal carcinomatosis-bearing mouse model. Collectively, it not only provides a novel strategy to advanced AIE dots for cancer phototheranostics, but also brings new insights into the design of superior fluorescent NPs for biomedical applications.
Planar and Twisted Molecular Structure Leads to the High Brightness of Semiconducting Polymer Nanoparticles for NIR-IIa Fluorescence Imaging
Publisher: American Chemical Society (ACS)
Date: 05-08-2020
DOI: 10.1021/JACS.0C07193
A Universal Boronate‐Affinity Crosslinking‐Amplified Dynamic Light Scattering Immunoassay for Point‐of‐Care Glycoprotein Detection
Publisher: Wiley
Date: 23-12-2022
Abstract: Herein, we report a universal boronate‐affinity crosslinking‐ lified dynamic light scattering (DLS) immunoassay for point‐of‐care (POC) glycoprotein detection in complex s les. This enhanced DLS immunoassay consists of two elements, i.e., antibody‐coated magnetic nanoparticles (MNP@mAb) for target capture and DLS signal transduction, and phenylboronic acid‐based boronate‐affinity materials as crosslinking lifiers. Upon the addition of targets, glycoproteins are first captured by MNP@mAb and lified by target‐induced crosslinking stemming from the selective binding between the boronic acid ligand and cis ‐diol‐containing glycoprotein, thereby resulting in a remarkably increased DLS signal in the average nanoparticle size. Benefiting from the multivalent binding and fast boronate‐affinity reaction between glycoproteins and crosslinkers, the proposed immunosensing strategy has achieved the ultrasensitive and rapid quantitative assay of glycoproteins at the fM level within 15 min. Overall, this work provides a promising and versatile design strategy for extending the DLS technique to detect glycoproteins even in the field or at POC.
Three‐Pronged Attack by Hybrid Nanoplatform Involving MXenes, Upconversion Nanoparticle and Aggregation‐Induced Emission Photosensitizer for Potent Cancer Theranostics
Publisher: Wiley
Date: 03-06-2022
Abstract: Inspired by the excellent photothermal conversion ability and inherent nanomedicine platform property of MXenes, efficient reactive oxygen species production and prominent fluorescence emission feature of aggregation‐induced emission (AIE)‐active photosensitizers (PSs), as well as the extending excitation wavelength capability of upconversion nanoparticles (UCNPs), a versatile nanoplatform comprised of Ti 3 C 2 nanosheets (NSs), AIE‐active PSs and UCNPs is intelligently fabricated. This three‐pronged strategy takes advantages of each component simultaneously, and realizes fluorescence imaging hotoacoustic imaging hotothermal imaging triple‐modal imaging‐guided photothermal hotodynamic synergetic therapy under 808 nm laser irradiation. The introduction of UCNPs actualizes the long wavelength‐activation of AIE‐active PSs, which significantly increases the tissue penetration depth. Spatially isolation of AIE‐active PSs and Ti 3 C 2 NSs is beneficial for suppressing the fluorescence quenching effect of Ti 3 C 2 NSs, bringing about ultimately brilliant fluorescence. The covalently bonded polymer surface endows the nanoplatform with excellent physiological stability and efficient tumor accumulation. These outputs reveal a win‐win cooperation of multiple inorganic/organic nanocomposites for phototheranostics, and present great potential for future clinical translations.
A Conjugated Polymeric Supramolecular Network with Aggregation‐Induced Emission Enhancement: An Efficient Light‐Harvesting System with an Ultrahigh Antenna Effect
Publisher: Wiley
Date: 03-09-2020
Abstract: Superior artificial light-harvesting systems (ALHSs) require exceptional capacity in harvesting light and transferring energy. In this work, we report a novel strategy to build ALHSs with an unprecedented antenna effect (35.9 in solution and 90.4 in solid film). The ALHSs made use of a conjugated polymeric supramolecular network (CPSN), a crosslinked network obtained from the self-assembly of a pillar[5]arene-based conjugated polymeric host (CPH) and conjugated ditopic guests (Gs). The excellent performance of the CPSN could be attributed to the following factors: 1) The "molecular wire effect" of the conjugated polymeric structure, 2) aggregation-induced enhanced emission (AEE) moieties in the CPH backbone, and 3) high capacity of donor-acceptor energy transfer, and 4) crosslinked structures triggered by the host-guest binding between Gs and CPH. Moreover, the emission of the CPSN could be tuned by using different Gs or varying the host/guest ratio, thus reaching a 96 % sRGB area.
Modular Construction of AIE-Active Supramolecular Cages with Tunable Fluorescence for NIR-II Blood Vessel Imaging
Publisher: American Chemical Society (ACS)
Date: 26-06-2023
Metastable biological matter in liquid phase separation
Publisher: Wiley
Date: 28-09-2023
Recent progress in the applications of amino–yne click chemistry
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1PY00113B
Abstract: This mini-review summarizes the recent research studies on the application of the amino–yne click reaction in surface immobilization, construction of drug delivery systems, preparation of hydrogel materials and synthesis of functional polymers.
AIEgens in Solar Energy Utilization: Advances and Opportunities
Publisher: American Chemical Society (ACS)
Date: 15-07-2022
DOI: 10.1021/ACS.LANGMUIR.2C01036
Abstract: Solar energy is the most abundant energy resource on earth. Unfortunately, only a very small portion of the solar radiation can be utilized by current light-harvesting materials, thus leading to the poor utilization efficiency of solar energy. In this regard, aggregation-induced emission luminogens (AIEgens) have demonstrated versatile properties that can enhance energy conversion and potentially revolutionize solar utilization systems. AIEgens with great processability can selectively absorb radiation across multiple spectral regions and transform solar energy into longer-wavelength light, heat, or alternative forms of energy. These processes can considerably enhance the solar energy utilization performance by either developing light-harvesting systems based on AIEgens or hybridizing modern light-harvesting systems with AIE technology. In this Perspective, based on material properties, we highlight different functions of AIEgens related to solar light utilization, including sunlight transformation, chemical conversion, and thermal conversion.
Efficient NIR-II Type-I AIE Photosensitizer for Mitochondria-Targeted Photodynamic Therapy through Synergistic Apoptosis–Ferroptosis
Publisher: American Chemical Society (ACS)
Date: 05-05-2023
Redox-Active AIEgen-Derived Plasmonic and Fluorescent Core@Shell Nanoparticles for Multimodality Bioimaging
Publisher: American Chemical Society (ACS)
Date: 09-05-2018
DOI: 10.1021/JACS.8B02350
Abstract: Multimodality imaging is highly desirable for accurate diagnosis by achieving high sensitivity, spatial-temporal resolution, and penetration depth with a single structural unit. However, it is still challenging to integrate fluorescent and plasmonic modalities into a single structure, as they are naturally incompatible because of significant fluorescence quenching by plasmonic noble-metal nanoparticles. Herein, we report a new type of silver@AIEgen (aggregation-induced emission luminogen) core-shell nanoparticle (AACSN) with both strong aggregated-state fluorescence of the AIEgen and distinctive plasmonic scattering of silver nanoparticles for multimodality imaging in living cells and small animals. The AACSNs were prepared through a redox reaction between silver ions and a redox-active AIEgen, which promoted synergistic formation of the silver core and self-assembly of the AIEgen around the core. The resulting AACSNs exhibited good biocompatibility and high resistance to environmental damage. As a result, excellent performance in fluorescence imaging, dark-field microscopy, and X-ray computed tomography-based multimodality imaging was achieved.
H2O2‐Responsive NIR‐II AIE Nanobomb for Carbon Monoxide Boosting Low‐Temperature Photothermal Therapy
Publisher: Wiley
Date: 29-07-2022
Abstract: Low‐temperature photothermal therapy (PTT), which circumvents the limitations of conventional PTT (e.g., thermotolerance and adverse effects), is an emerging therapeutic strategy which shows great potential for future clinical applications. The expression of heat shock proteins (HSPs) can dramatically impair the therapeutic efficacy of PTT. Thus, inhibition of HSPs repair and reducing the damage of nearby normal cells is crucial for improving the efficiency of low‐temperature PTT. Herein, we developed a nanobomb based on the self‐assembly of NIRII AIE polymer PBPTV and carbon monoxide (CO) carrier polymer mPEG(CO). This smart nanobomb can be exploded in a tumor microenvironment in which hydrogen peroxide is overexpressed and release CO into cancer cells to significantly inhibit the expression of HSPs and hence improve the antitumor efficiency of the low‐temperature PTT.
Type-I AIE Photosensitizer Loaded Biomimetic System Boosting Cuproptosis to Inhibit Breast Cancer Metastasis and Rechallenge
Publisher: American Chemical Society (ACS)
Date: 15-05-2023
Codes in Code: AIE Supramolecular Adhesive Hydrogels Store Huge Amounts of Information
Publisher: Wiley
Date: 20-09-2021
Abstract: With the continuous advancement of information technology, the requirements for the information storage capacity of materials are getting higher and higher. However, information code materials usually only store a single piece of information. In order to improve their storage capacity, aggregation‐induced emission (AIE) supramolecular adhesive hydrogels with different fluorescent colors are prepared, and a “Codes in Code” method is used to demonstrate the storage capacity for large amounts of information. Four kinds of poly(vinyl alcohol) (PVA) supramolecular hydrogels with different fluorescent colors are prepared based on the hydrogen bonds on the hydrogel surface, these hydrogels can be assembled into a hydrogel, G5 , which shows multiple fluorescent colors under the irradiation of UV light. When many 1D barcode patterns or/and 2D code patterns are incorporated into G5 , not only a kind of 3D information but also plenty of 1D or/and 2D information can be stored. Therefore, the information codes prepared by the “Codes in Code” method can store a large amount of information.
Enantioselective determination of chiral acids and amino acids by chiral receptors with aggregation-induced emissions
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2QO01073A
Abstract: The chiral AIEgens showed satisfying enantiomer discrimination not only for amino acids but also for chiral acids.
Violet-Blue Emitters Featuring Aggregation-Enhanced Emission Characteristics for Nondoped OLEDs with CIEy Smaller than 0.046
Publisher: American Chemical Society (ACS)
Date: 21-09-2020
In Situ Synthesis of AIEgen‐based Porous Organic Polymer Films by Interfacial Amino‐yne Click Polymerization for Efficient Light‐Harvesting
Publisher: Wiley
Date: 23-03-2023
Abstract: We developed a catalyst‐free, atom‐economical interfacial amino‐yne click polymerization to in situ synthesize new aggregation‐induced emission luminogen (AIEgen)‐based free‐standing porous organic polymer films at room temperature. The crystalline properties of POP films were confirmed by powder X‐ray diffraction and high‐resolution transmission electron microscopy. The good porosity of these POP films was proved by their N 2 uptake experiments. The thickness of POP films can be easily regulated from 16 nm to ≈1 μm by adjusting monomer concentration. More importantly, these AIEgen‐based POP films show bright luminescence with high absolute photoluminescent quantum yields up to 37.8 % and good chemical and thermal stability. The AIEgen‐based POP film can encapsulate an organic dye (e.g., Nile red) to further form an artificial light‐harvesting system with a large red‐shift (Δ λ =141 nm), highly efficient energy‐transfer ability ( Φ ET =91 %), and high antenna effect (11.3).
Precise Molecular Engineering of Small Organic Phototheranostic Agents toward Multimodal Imaging-Guided Synergistic Therapy
Publisher: American Chemical Society (ACS)
Date: 02-04-2021
Deep-Red Aggregation-Induced Emission Luminogen Based on Dithiofuvalene-Fused Benzothiadiazole for Lipid Droplet-Specific Imaging
Publisher: American Chemical Society (ACS)
Date: 16-12-2021
Synergistic tuning of the optical and electrical performance of AIEgens with a hybridized local and charge-transfer excited state
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9TC01453E
Abstract: Combining HLCT and AIE characteristics, six phenanthroimidazole derivatives were designed with different patterns for high-efficiency non-doped OLEDs.
Catalyst-Free Multicomponent Tandem Polymerizations of Alkyne and Amines toward Nontraditional Intrinsic Luminescent Poly(aminomaleimide)s
Publisher: American Chemical Society (ACS)
Date: 07-05-2020
Fluorination Enhances NIR‐II Emission and Photothermal Conversion Efficiency of Phototheranostic Agents for Imaging‐Guided Cancer Therapy
Publisher: Wiley
Date: 11-12-2023
Abstract: Phototheranostics with second near‐infrared (NIR‐II) imaging and photothermal effect have become a burgeoning biotechnology for tumor diagnosis and precise treatment. As important parameters of phototheranostic agents (PTAs), fluorescence quantum yield (QY) and photothermal conversion efficiency (PCE) are usually considered as a pair of contradictions that is difficult to be simultaneously enhanced. Herein, a fluorination strategy for designing A–D–A type PTAs with synchronously improved QY and PCE is proposed. Experimental results show that the molar extinction coefficient (ε), NIR‐II QY, and PCE of all fluorinated PTAs nanoparticles (NPs) are definitely improved compared with the chlorinated counterparts. Theoretical calculation results demonstrate that fluorination can maximize the electrostatic potential difference by virtue of the high electronegativity of fluorine, which may increase intra/intermolecular D–A interactions, tighten molecule packing, and further promote the increase of ε, ultimately leading to simultaneously enhanced QY and PCE. In these PTA NPs, FY6‐NPs display NIR‐II emission extended to 1400 nm with the highest NIR‐II QY (4.2%) and PCE (80%). These features make FY6‐NPs perform well in high‐resolution imaging of vasculature and NIR‐II imaging‐guided photothermal therapy (PTT) of tumors. This study develops a valuable guideline for constructing NIR‐II organic PTAs with high performance.
M13 Bacteriophage-Assisted Recognition and Signal Spatiotemporal Separation Enabling Ultrasensitive Light Scattering Immunoassay
Publisher: American Chemical Society (ACS)
Date: 12-09-2023
The influence of intermolecular interactions and molecular packings on mechanochromism and mechanoluminescence – a tetraphenylethylene derivative case
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9TC04501E
Abstract: Compact packing and intact three-dimensional hydrogen-bonded networks in single crystals are favorable for ML properties.
Related Organisations
International Society For Optical Engineering
Location: No location found
Xiangshan Science Conference On Aggregation-Induced Emission
Location: China
The XIXth International Krutyn Summer School On Aggregation-Induced Emission (AIE): Phenomenon, Principle And Application
Location: Poland
TSRC Workshop On Shape-Responsive Fluorophores
Location: United States of America
The International Conference On Advanced Fibers And Polymer Materials
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Workshop Of UGC AoE On Institute Of Molecular Functional Materials
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The 1st International Symposium On Aggregation-Induced Emission
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The 1st International Electronic Conference On Polymers
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The 4th International Conference On Photoresponsive Organics And Polymers
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The 3rd International Symposium On Aggregation-Induced Emission
Location: Singapore
Symposium On Superconductive And Magnetic Materrials, The 1st International Congress On Advanced Materials
Location: Pakistan
Symposium On Electroactive And Photoresponsive Metal-Containing Polymers At The 231st ACS National Meeting In San Francisco
Location: China
The 13rd International Symposium On Functional Π-Electron Systems
Location: Hong Kong
Taylor & Francis Group
Location: United Kingdom of Great Britain and Northern Ireland
The Hong Kong Chapter Of The American Chemical Society
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The 9th International Symposium On Polymers For Advanced Technologies
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The 5th Unilever–RSC International Symposium On Functional Materials Science
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Organizing Committee Of The 2017 International Academic Forum Of Hybrid Materials
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Organizing Committee Of The 1st World Congress On Nano Science And Nano Technology
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Organizing Committee Of The 2nd International Conference On Biomedical Applications Of Nanomaterials
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Organizing Committee Of The 2nd FAPS Polymer Congress
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Organizing Committee Of The 10th National Meeting On Organic Solid Electronic Processes
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Optoelectronics Science & Technology Frontiers Series, Science Press
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Pacifichem 2015 Chemical Congress (Symposium On Aggregation Induced Emission: Materials And Applications)
Location: United States of America
Pacifichem 2010 Chemical Congress (Symposium On Electron Transfer And Electrochemistry Of Transition Metal-Containing Inorganic And Organometallic Materials)
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Organizing Committee Of The International Conference On Biomedical Application Of Nanomaterials
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Organizing Committee Of The Cross-Strait Symposium On Macromolecular Liquid Crystals And Supramolecular Ordered Systems
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Organizing Committee Of The National Meeting Of Polymer Science Of The Chinese Chemical Society
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Organizing Committee Of The National Congress Of Polymer Science
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Local Organizing Committee Of Optical Probes Of Conjugated Polymers And Organic Nanostructures
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Local Organizing Committee Of The 25th International Symposium On Chirality
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Journal Of Molecular And Engineering Materials, World Scientific
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Journal Of Inorganic And Organometallic Polymers And Materials, Volume 17, Issue 1
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Journal Of Molecular Engineering & Systems Biology, Herbert Publications Limited
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National Polymer Conference Of The Chinese Chemical Society
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Molecular Diversity Preservation International (MDPI), Switzerland
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Nature Publishing Group
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Materials Chemistry Frontiers, Royal Society Of Chemistry
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Scientific Committee Of The International Conference On Optoelectronics And Spectroscopy Of Nanostructured Thin Films And Materials
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Program Committee Of The 15th Pacific Polymer Conference
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Scientific Advisory Committee Of The 9th National Meeting On Luminescence From Organic Molecules And Polymers
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Scientific Advisory Committee Of The 8th National Meeting On Molecular Chirality
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Committee For Poster Prizes, IUPAC World Polymer Congress
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4th International Symposium On High-Tech Polymer Materials
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Academic Committee, International Conference On Advanced Fibers And Polymer Materials
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Academic Committee Of International Organic Electronics Workshop
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16th International Symposium On Fine Chemistry And Functional Polymers & IUPAC 2nd International Symposium On Novel Materials And Synthesis
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Advisory Committee Of The 7th National Meeting On Organic And Polymeric Luminescent And Optoelectronic Materials
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Advisory Committee Of The 2nd Conference On Organic Optoelectronics
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Aggregation-induced Emission: Phenomena, Materials And Application Wiley
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Academic Committee/Advisory Board Of Advanced Materials World Congress
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Advisory Committee Of The 1st International Congress On Advanced Materials
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International Advisory Board Of The 1st International Symposium On Nature Product, Biotechnology And Catalysis
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International Advisory Committee Of The International Conference On Recent Frontiers In Applied Spectroscopy
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International Advisory Board Of The 1st Asian Forum On Clean Energy & Advanced Materials
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International Advisory Board Of SETCOR International Conference On Smart Materials And Surfaces
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International Organizing Committee Of The 1st International Energy & Environmental Materials Forum And 3rd Inorganic & Nanomaterials Forum
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Related Funding Activities
No related grants have been discovered for Ben Zhong Tang.