ORCID Profile
0000-0002-6704-9808
Current Organisation
University of Western Australia
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Geodynamics | Geology | Tectonics | Inorganic Geochemistry | Structural Geology | Basin Analysis | Geochemistry
Expanding Knowledge in the Earth Sciences | Mineral Exploration not elsewhere classified | Copper Ore Exploration | Precious (Noble) Metal Ore Exploration | Climate and Climate Change not elsewhere classified |
Publisher: Elsevier BV
Date: 10-2018
Publisher: Springer Science and Business Media LLC
Date: 31-01-2022
DOI: 10.1038/S41467-022-28275-Y
Abstract: Magmatic arcs are terrestrial environments where lithospheric cycling and recycling of metals and volatiles is enhanced. However, the first-order mechanism permitting the episodic fluxing of these elements from the mantle through to the outer Earth’s spheres has been elusive. To address this knowledge gap, we focus on the textural and minero-chemical characteristics of metal-rich magmatic sulfides hosted in hibole-olivine-pyroxene cumulates in the lowermost crust. We show that in cumulates that were subject to increasing temperature due to prolonged mafic magmatism, which only occurs episodically during the complex evolution of any magmatic arc, Cu-Au-rich sulfide can exist as liquid while Ni-Fe rich sulfide occurs as a solid phase. This scenario occurs within a ‘Goldilocks’ temperature zone at ~1100–1200 °C, typical of the base of the crust in arcs, which permits episodic fractionation and mobilisation of Cu-Au-rich sulfide liquid into permeable melt networks that may ascend through the lithosphere providing metals for porphyry and epithermal ore deposits.
Publisher: Wiley
Date: 11-01-2015
DOI: 10.1111/RESP.12463
Publisher: Wiley
Date: 10-2014
DOI: 10.1111/PAI.12265
Abstract: The impact of breast milk feeding on susceptibility to asthma in childhood is highly controversial, due in part to failure of the majority of studies in the area to adequately account for key confounders exemplified by respiratory infection history, plus the effects of recall bias. As part of a prospective cohort study on the role of respiratory infections in asthma development in high-risk children, we measured the concentration of a panel of anti-infective proteins in maternal milk s les and analyzed associations between these and subsequent atopy-, infection-, and asthma-related outcomes prospectively to age 10 years. We observed significant but transient inverse associations between the concentration of milk proteins and susceptibility to upper respiratory infections in year 1 only, and parallel but positive transient associations with early lower respiratory infections and atopy. No associations were seen with asthma-related outcomes. Breast milk feeding may influence the expression of inflammatory symptoms associated with respiratory infections and atopy in early life, but these effects appear to be inconsistent and transient. The heterogeneous nature of breast-feeding effects suggests it may influence systemic immunoinflammatory function at several different levels.
Publisher: Elsevier BV
Date: 09-2020
Publisher: Elsevier BV
Date: 04-2018
Publisher: Elsevier BV
Date: 02-2022
Publisher: Elsevier BV
Date: 11-2013
Publisher: Elsevier BV
Date: 02-2014
Abstract: The relative importance of respiratory viral infections vs inhalant allergy in asthma pathogenesis is the subject of ongoing debate. Emerging data from long-term prospective birth cohorts are bringing increasing clarity to this issue, in particular through the demonstration that while both of these factors can contribute independently to asthma initiation and progression, their effects are strongest when they act in synergy to drive cycles of episodic airways inflammation. An important question is whether susceptibility to infection and allergic sensitization in children with asthma arises from common or shared defect(s). We argue here that susceptibility to recurrent respiratory viral infections, failure to generate protective immunologic tolerance to aeroallergens, and ultimately the synergistic interactions between inflammatory pathways triggered by concomitant responses to these agents all result primarily from functional deficiencies within the cells responsible for local surveillance for antigens impinging on airway surfaces: the respiratory mucosal dendritic cell (DC) network. The effects of these defects in DCs from children wtih asthma are accentuated by parallel attenuation of innate immune functions in adjacent airway epithelial cells that reduce their resistance to the upper respiratory viral infections, which are the harbingers of subsequent inflammatory events at asthma lesion site(s) in the lower airways. An important common factor underpinning the innate immune functions of these unrelated cell types is use of an overlapping series of pattern recognition receptors (exemplified by the Toll-like receptor family), and variations in the highly polymorphic genes encoding these receptors and related molecules in downstream signaling pathways appear likely contributors to these shared defects. Findings implicating recurrent respiratory infections in adult-onset asthma, much of which is nonatopic, suggest a similar role for deficient immune surveillance in this phenotype of the disease.
Publisher: Elsevier BV
Date: 09-2019
Publisher: Springer Science and Business Media LLC
Date: 16-04-2014
DOI: 10.1007/S11356-014-2882-Z
Abstract: Bisphenol A (BPA) is used extensively in food-contact materials and has been detected routinely in populations worldwide this exposure has been linked to a range of negative health outcomes in humans. There is some evidence of an association between BPA and different socioeconomic variables which may be the result of different dietary patterns. The aim of this study was to conduct a preliminary investigation of the association between BPA and socioeconomic status in Australian children using pooled urine specimens and an area-level socioeconomic index. Surplus pathology urine specimens collected from children aged 0-15 years in Queensland, Australia, as s les of convenience (n=469), were pooled by age, sex and area-level socioeconomic index (n=67 pools) and analysed for total BPA using online solid-phase extraction LC-MS/MS. Concentration ranged from 1.08 to 27.4 ng/ml with geometric mean 2.57 ng/ml, and geometric mean exposure was estimated as 70.3 ng/kg d(-1). Neither BPA concentration nor excretion was associated with age or sex, and the authors found no evidence of an association with socioeconomic status. These results suggest that BPA exposure is not associated with socioeconomic status in the Australian population due to relatively homogenous exposures in Australia, or that the socioeconomic gradient is relatively slight in Australia compared with other OECD countries.
Publisher: Elsevier BV
Date: 2012
Publisher: Elsevier BV
Date: 2015
Publisher: Elsevier BV
Date: 12-2014
Publisher: Elsevier BV
Date: 12-2020
Publisher: Elsevier BV
Date: 12-2020
Publisher: Elsevier BV
Date: 08-2016
Publisher: American Geophysical Union (AGU)
Date: 08-2017
DOI: 10.1002/2017JB014051
Publisher: Informa UK Limited
Date: 12-2018
Publisher: Elsevier BV
Date: 2015
Publisher: Elsevier BV
Date: 07-2019
Publisher: Informa UK Limited
Date: 11-11-2019
Publisher: Springer Science and Business Media LLC
Date: 25-05-2022
Publisher: American Geophysical Union (AGU)
Date: 03-2018
DOI: 10.1002/2017TC004738
Publisher: Wiley
Date: 22-06-2014
DOI: 10.1111/JPC.12672
Abstract: (i) To compare the Centers for Disease Control and Prevention (CDC) reference and World Health Organization (WHO) standard/reference for height, particularly with respect to short stature and eligibility for growth hormone (GH) treatment by applying them to contemporary Australian children (ii) To examine the implications for identifying short stature and eligibility for GH treatment. Children from the longitudinal Raine Study were serially measured for height from 1991 to 2005 (2-15-year-old girls (660) and boys (702) from Western Australia). In the cross-sectional Australian National Children's Nutrition and Physical Activity survey (2-16-year-old boys (2415) and girls (2379) from all states), height was measured in 2007. Heights were converted to standard deviation scores (SDSs) based on CDC and WHO. Means and standard deviations of height-SDS varied between CDC and WHO definitions and with age and gender within each definition. However, both identified similar frequencies of short stature (<1st centile for GH eligibility), although these were very significantly less than the anticipated 1% (0.1-0.7%) of the Australian cohorts. Mean heights in the Australian cohorts were greater than both the WHO and CDC means. Neither CDC nor WHO height standardisations accurately reflect the contemporary Australian child population. Australian children are taller than the CDC or WHO height means, and significantly less than 1% of Australian children are defined as being short using either CDC or WHO. This study suggests there may be a case for an Australian-specific standard/reference for height.
Publisher: Elsevier BV
Date: 06-2017
Publisher: Copernicus GmbH
Date: 29-08-2023
Abstract: Abstract. Basin inversion is commonly attributed to the reverse reactivation of basin-bounding normal faults. This association implies that basin uplift and inversion-related structures are mainly controlled by the frictional behaviour of pre-existing faults and associated damage zones. In this study, we use lithospheric-scale analogue experiments of orthogonal extension followed by shortening to explore how the flow behaviour of ductile layers underneath rift basins promote or suppress basin inversion. Our experiments show that the rheology of the ductile lower crust and lithospheric mantle, modulated by the imposed bulk strain rate, determine (1) basin distribution in a wide rift setting and (2) strain accommodation by fault reactivation and basin uplift during subsequent shortening. When the ductile layers deform uniformly during extension (i.e. stretching) and shortening (i.e. thickening), all of the basins are inverted. When deformation in the ductile layers is localised during extension (i.e. necking) and shortening (i.e. folding), only some basins – which are evenly spaced apart – are inverted. We interpret the latter as selective basin inversion, which may be related to the superposition of crustal-scale and lithospheric-scale boudinage during the previous basin-forming extensional phase and/or folding of the ductile layers during shortening.
Publisher: Wiley
Date: 25-11-2015
DOI: 10.1111/ANAE.12946
Abstract: Three quarters of all critical incidents and a third of all peri-operative cardiac arrests in paediatric anaesthesia are caused by adverse respiratory events. We screened for risk factors from children's and their families' histories, and assessed the usefulness of common markers of allergic sensitisation of the airway as surrogates for airway inflammation and increased risk for adverse respiratory events. One hundred children aged up to 16 years with two or more risk factors undergoing elective surgery were included in the study. Eosinophil counts, IgE level, specific IgE for D. pteronyssinus, cat epithelia and Gx2 (grass pollen) were measured for each child and adverse respiratory events (bronchospasm, laryngospasm, oxygen desaturation < 95%, severe persistent coughing, airway obstruction and postoperative stridor) were recorded. Twenty-one patients had an adverse respiratory event but allergic markers were poor predictors. Binary logistic regression showed a lack of predictive value of the eosinophil range and adverse respiratory events (p = 0.249). Receiver operating characteristic (ROC) curves for the presence of adverse respiratory events vs level of specific IgE antibody (to Gx2 (AUC 0.614), cat epithelia (0.564) and D. pteronyssinus (0.520)) demonstrated poor predictive values. However, the presence of risk factors was strongly associated with adverse respiratory events (p < 0.001) and a ROC-curve analysis indicated a fair capacity to predict adverse respiratory events (AUC 0.788). There was a significant difference (p = 0.001) between the presence of adverse respiratory events in patients with more than four (p = 0.006), compared with less than four (p = 0.001), risk factors. We conclude that while risk factors taken from the child's (or family) history proved good predictors of adverse respiratory events, immunological markers of allergic sensitisation demonstrated low predictive values. Pre-operative identification of children at high risk for an adverse respiratory event should rely on clinical, rather than immunological, assessment.
Start Date: 12-2019
End Date: 12-2023
Amount: $450,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 03-2011
End Date: 12-2015
Amount: $550,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 08-2020
End Date: 08-2024
Amount: $1,055,000.00
Funder: Australian Research Council
View Funded Activity